Lesion celular.

Muerte celular
Docente: Sonia Adelaida Pereyra Lopez
Grupo: spereyral-103802>06T15-4
Integrantes:
Atúncar Vilela, Carla Patricia -2020224838
Vaughan Poggi, Nicole - 2020225683
Mallely Alizon Villantoy Cabezas - 2020208163
Leva Zaquinaula Daysi Jesus - 2018200692
Videl Alessandra Gonzales Rivera - 2017202642
TABLE OF CONTENTS
01 04
Introducción NETosis en COVID 19

02 05
Formación de los NETsTerapia de NETosis

03
NETosis en enfermedades autoinmunes
 01

QUÉ ES LA NETosis?
Es un mecanismo de los neutrófilos para la
formación de trampas celulares, que
consisten en cormatina modificada
asociada a proteínas bactericiads de
gránulos y citoplasma.
Hay varios estímulos que pueden casuar la
NETosis, como patógenos, anticuerpos y
complejos inmunes, citoquinas,
microcristales.
FORMACIÓN DE LOS
NETs 02

1. Pérdida de forma lobulada

2. Hay una homogenización de la eucromatina y
heterocromatina
3. Ruptura de su membrana nuclear y disolición de los gránulos
citoplasmáticos
4. Mezcla de componentes celulares y nucleares
5. Ruptura de la membrana celular y liberación al medio
extracelular
 NETosis en enfermedades autoinmunes

Promueven la producción de anticuerpos y

patológicamente la NETosis juega un rol
importante en el desarrollo de las patologías
autoinmunes debido a la exposición de
autoantígenos que pueden ser nucleares o de
los gránulos antimicrobianos en el espacio
extracelular
 NETs en el COVID 19

Con respecto al COVID 19 , se han descrito grandes niveles de NETs en los pacientes, recordemos que en la
netosis “atrapan” a los patógenos por sus redes
(que contienen ADN, histonas , enzimas oxidativas y proteínas microbicidas) e impiden su replicación
favoreciendo así su eliminación.
Pero también los NETs dañan directamente a los tejidos colaterales ante las infecciones respiratorias en
donde eliminan células endoteliales y epiteliales. En los pacientes se observó un aumento de MPO-ADN e histona-
H3 citrulinada que son los marcadores de la formación de NETs.
 4.-¿EN QUÉ CONSISTE LA TERAPIA DE LA NETOSIS?

Destruye o inhibe el
NETOSIS crecimiento de los
microorganismos

Bacterias
Producción in vitro se presenta entre 5 Hongos
TERAPIA DE NETs
BIOLOG
minutos y 4 horas después del estímulo Parásitos
bacterias, hongos, parásitos, virus y
Virus
plaquetas activadas.
ICOS Plaquetas
activadas.

INDUCTADORES PMA
IL-8
DE NETS H2O2
ácido nítrico
PATIENT MEDICAL HISTORY

AGE: 25 - 35
GENDER: Female
ALLERGIES: None
LOCATION: Madrid,
Spain

Despite being red, Mars is a Jupiter is a gas giant and the Saturn is the ringed one. It’s a
cold place, not hot. It’s full of biggest planet in our Solar gas giant, composed mostly
iron oxide dust of hydrogen and helium
System

2xxx 2xxx 2xxx

REVIEW OF SYSTEMS

Jupiter is a gas giant and Saturn is the ringed one.

the biggest planet in our It’s composed mostly of
Despite being red, Mars is Solar System hydrogen and helium
a cold place. The planet is
full of iron oxide dust
 RESULTS

Mercury is the closest planet to the Sun

and the smallest one in the Solar
System—it’s only a bit larger than our
Moon. The planet’s name has nothing
to do with the liquid metal since it was
named after the Roman messenger
god, Mercury
FINDINGS

EVOLUTION PREVALENCE

10% 30% 40% 20%

If you want to modify these graphs, click on them, follow

the link, change the data and replace them
200,000,000
BIG NUMBER
 DR. JENNA JAMES

“Despite being red, Mars is a

DISCUSSION cold place, not hot. It’s full of
iron oxide dust, which gives
DR. JOHN DOE the planet its reddish cast”

“Jupiter is a gas giant and the

biggest planet in our Solar
System. It’s the fourth-
brightest object in the sky”

DR. DANIEL
PATTERSON
“Mercury is the closest planet
to the Sun and the smallest
one in our Solar System. It’s
only a bit larger than our
Moon”
 CONCLUSIONES:

Los NETs son mecanismos de respuesta de la inmunidad innata cuando hay una
infección en donde una malla de ADN es liberada y encierra proteínas e histonas y su
formación depende del tipo del estímulo empleado y del tiempo.
BIBLIOGRAFÍAS:
TREATMENT

VENUS
Venus has a beautiful
name and is the second
planet from the Sun. It’s
hotter than Mercury and
its atmosphere is
poisonous

MERCU
MercuryRYis the closest
planet to the Sun and
the smallest one in the
Solar System—it’s only
a bit larger than our
Moon
PATIENT MONITORING

Mercury is the closest planet to WEEK 1 WEEK 2 Despite being red, Mars is a cold
the Sun and the smallest one place, not hot

MER MER
CURY CURY
MAR MAR
S S
SATU SATU
RN RN

MER MER
CURY CURY
MAR MAR
S S
SATU SATU
RN RN
Jupiter is the biggest planet in our Saturn is a gas giant, composed
Solar System WEEK 3 WEEK 4 mostly of hydrogen and helium
CONTRAINDICATIONS & INDICATIONS

1. Here you can describe the reason 1. Here you can describe the reason
to stop the treatment to carry on with the treatment

2. Here you can describe the reason 2. Here you can describe the reason
to stop the treatment to carry on with the treatment

3. Here you can describe the reason 3. Here you can describe the reason
to stop the treatment to carry on with the treatment

4. Here you can describe the reason 4. Here you can describe the reason
to stop the treatment to carry on with the treatment
POST-PREVENTION
Despite being red, Mars is a
cold place, not hot
Mercury is the closest planet
to the Sun

Venus has a beautiful name, Neptune is the farthest planet

but it’s terribly hot from the Sun
CASE TIMELINE

Jupiter is the The Sun is the star

biggest planet in at the center of the
our Solar System Solar System

1 2 3 4

Mercury is the Despite being red,

smallest planet in Mars is a cold
our Solar System place, not hot
CONCLUSIONS

CONCLUSIONS
Mercury is the closest planet to the Sun and the
smallest one in the Solar System—it’s only a bit
larger than our Moon. The planet’s name has
nothing to do with the liquid metal since it was
named after the Roman messenger god, Mercury
REFERENCES

AUTHOR (YEAR). Title of the publication. Publisher

AUTHOR (YEAR). Title of the publication. Publisher

AUTHOR (YEAR). Title of the publication. Publisher

AUTHOR (YEAR). Title of the publication. Publisher

AUTHOR (YEAR). Title of the publication. Publisher

AUTHOR (YEAR). Title of the publication. Publisher

OUR TEAM JOHN PATTERSON

Here you can talk a bit

about this person

HELENA JAMES

Here you can talk a bit

about this person
JENNA DOE

Here you can talk a bit

about this person
THANKS
Does anyone have any questions?

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