3/06/22

Universidad Nacional Agraria La Molina

Departamento Académico de Quìmica

Esta presentación es para uso exclusivo de los Bioquìmica 2022-I

estudiantes matriculados en el Grupo Z del curso de
Bioquímica, semestre 2022-I, de la Universidad Carbohidratos: oxidación
Nacional Agraria La Molina Parte 3

Prof. Ana A. Kitazono Sugahara

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Energía libre
Hexoquinasa
estándar de
hidrólisis de algunos
organofosfatos de
Glucólisis importancia
Fosfofructo bioquímica
quinasa1

Piruvato
quinasa
Harper Bioquímica Ilustrada.
McGraw-Hill Interamericana

49 50

1
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Tres pasos irreversibles

catalizados por enzimas
reguladoras
Regulación
hormonal
de glicòlisis

Bioquìmica – Conceptos esenciales – Feduchi et al.

51 52

Fructosa 2,6-bifosfato: regulador alostérico de la fosfofructo

quinasa 1 (PPK1, FFQ1) formado por acción de la fosfofructo
quinasa 2

53 54

2
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Síntesis de ATP por fosforilación a nivel de sustrato

Fructosa 2,6-bifosfato Fructosa 1,6-bifosfato

55 56

Energía libre
Hexoquinasa
estándar de
hidrólisis de algunos
organofosfatos de
importancia Glucólisis
bioquímica Fosfofructo
quinasa1

Piruvato
quinasa1
Harper Bioquímica Ilustrada.
McGraw-Hill Interamericana

57 58

3
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Ingreso de la fructosa a
glicólisis
(REFERENCIA)
Tejido adiposo Luis Federico Leloir (Argentina)
Premio Nobel en Quìmica 1970
Hígado

Bioquìmica – Conceptos esenciales – Feduchi et al. IUBMB Life, 64(6): 567–572, June 2012

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Recollections

Luis Federico Leloir, or How to Do Good S

Environment
(REFERENCIA) Armando J. Parodi
Luis Federico Leloir Ingreso de galactosa a la glicólisis Laboratory of Glycobiology, Fundación Instituto Leloir, Avda. Patricias Arg

Muy buen documental sobre su vida en youtube: EARLY YEARS: TRAINING IN MEDICINE AND went on to t
BIOCHEMISTRY UBA’s Schoo
https://youtu.be/4bd95W8hRqI
Luis Federico Leloir was born in one of Paris’ most upscale Ph.D. progra
neighborhoods (81, Avenue Victor Hugo, a few blocks away encouraged h
Y, otro sobre Bernardo Houssay quien fuera el maestro de Leloir y una de las máximas from the Arc de Triomphe) on September 6, 1906. According to Cambridge
figuras de la ciencia en Argentina. El documental se llama “Historia de una to his own account, his ancestors immigrated to Argentina dur- chemistry wi
voluntad”; ing the colonial period, coming mostly from southwestern Prize for Phy
https://youtu.be/Ptp-PGdORlI France (Oloron-Sainte Marie, in the Béarn region) and north-
eastern Spain (Basque Country). Argentine land at the time was
inexpensive because of the constant threat of attacks by natives, THE INSTIT
so the newly arrived went on to buy extensive farms. In time,
FATTY ACID
these would become the lands where the early pioneers would Leloir retu
grow the grain and raise cattle that would bring the country for 6 years h
wealth and prosperity. Such circumstances allowed Leloir an with Juan M.
early dedication to research. At that time, it was very difficult hypertension
(if not impossible) to get a full time position in Argentina. In the former
Bioquìmica – Conceptos esenciales – Feduchi et al. nates that we
The reasons for his family moving to Paris are quite sad:
61 62 Leloir’s father was terminally ill, and the Leloirs were in France may sound to
(in fact, the n
in search for a cure. Unfortunately, Leloir Sr. passed away
before his son was born. His mother brought him back to Bue- this finding a
nos Aires 2 years later and sent him to private schools before dotic note, ho
he finally enrolled in the School of Medicine of the University form a subce
of Buenos Aires (UBA). Leloir eventually got his M.D. degree inside the cel
be kept down
in 1932 and practiced medicine at the university’s Hospital. It
was not long before he approached the head of the School of 4 Leloir and M
Medicine’s Institute of Physiology, Bernardo Houssay, to start ated centrifug
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UDP-Glucosa Galactosa-1-P UDP-Glucosa Galactosa-1-P

Uridil Transferasa Uridil Transferasa
P P
P P Ga P Ga
Ga Ga Ga
P P
Ga Ga

T T
Glu E Glu E
Glu Glu
UDP UDP
Animación: Estudiante de Animación: Estudiante de
P
BQ2016II Sandro Valverde B. Glu BQ2016II Sandro Valverde B.

63 64

UDP-Glucosa Galactosa-1-P
Uridil Transferasa
P
Ga

P
Ga

T Glu E
Glu
UDP
P Animación: Estudiante de
P
Glu Glu BQ2016II Sandro Valverde B.

65