SISTIEMA GLINFATICO

Y SU ASOCIACION A ENFER MEDADES

NEURODEGENERATIVAS
Estudiante Edgar Fabricio Pacheco Friscioni
PERSPECTIVA HISTÓRICA
De la oscuridad neurocentrista hacia la luz glial
 ¿AUSENCIA DE CIRCULACIÓN
LINFÁTICA?
) (1755 – 1815
2015
Giovanni Paolo Mascagni Louveau y Aspelund: LYVE1, PROX1, and VEGFR3

1) Implications of the discovery of brain lymphatic pathways/ www.thelancet.com/neurology Vol 14 October

2015 2) Una nueva vía de drenaje cerebral: el sistema glinfático. Revisión histórica y conceptual/ Revista Mexicana de
Neurociencia Enero-Febrero, 2018;19 :104-116
VASOS LINFÁTICOS MENINGEALES , ABSINTA 2017

(1755 – 1815)
No es
suficiente

1)
https://www.researchgate.net/publication/321809038_Organ specific_lymphatic_vasculature_From_development_to_pathophysiology
2
VASOS LINFÁTICOS MENINGEALES , ABSINTA 2017

(1755 – 1815)

1)
https://www.researchgate.net/publication/321809038_Organ specific_lymphatic_vasculature_From_development_to_pathophysiology
2
 ¿QUE TIENEN QUE VER LOS
ASTROCITOS?

Making Maiken Nedergaard

1856 1885 1893 1893 1904 1918 1967

Paul Ehrlich Andriezen Stern y Gautier

“membrana “todo vaso “barrera”
limitante tiene adventicia pies de los
fisiológica” neuróglica” astrocitos

Michael
Rudolf von Lenhossék Santiago BHE y privilegio
«Nervenkitt»
Virchow “astrocitos” Ramón y Cajal inmune
1) Una nueva vía de drenaje cerebral: el sistema glinfático. Revisión histórica y conceptual/ Revista Mexicana de
Neurociencia Enero-Febrero, 2018;19 :104-116
 8- 50 micras distancia de
<8 neuronas
BHE ANATOMIA
Unidad neurovascular

1) Una nueva vía de drenaje cerebral: el sistema glinfático. Revisión histórica y conceptual/ Revista Mexicana de
Neurociencia Enero-Febrero, 2018;19 :104-116 2) The blood–brain barrier in psychosis/www.thelancet.com/psychiatry
Published online August 3, 2017
BHE FISIOLOGIA P-glycoprotein

a) Barrera paracelular

b) Barrera transcelular

c) Barrera enzimática

d) Transportadores de eflujo

-50nm

1) Una nueva vía de drenaje cerebral: el sistema glinfático. Revisión histórica y conceptual/ Revista Mexicana de
Neurociencia Enero-Febrero, 2018;19 :104-116 2) The blood–brain barrier in psychosis/www.thelancet.com/psychiatry
Published online August 3, 2017 3) Fisioologia Medica Boron y Boulpaep 284-287 / 3 ed Elsevier 2017
SENOS DURALES BHE AUSENTE

1)Fisioologia Medica Boron y Boulpaep 277 Y 284-287 / 3a ed Elsevier 2017

COMPARTIMENTOS DE LIQ.
500 ml plexo
coroideo
200 ml
endotelio

1) The Glymphatic System: A Beginner’s /GuideNeurochem Res (2015) 40:2583–2599

2) https://curiosoando.com/wp-content/uploads/2017/11/barreras-protectores-cerebrales.png
SISTEMA GLINFATICO
Un drenaje de en sueño
ANATOMIA GLINFATICA:
ESPACIO PERIVASCULAR Y LAMINA BASAL

500 ml plexo
coroideo
200 ml
endotelio

1) The Glymphatic System: A Beginner’s /GuideNeurochem Res (2015) 40:2583–2599 2) The Brain’s Glymphatic
System: Current Controversies/Trends in Neurosciences, July 2020, Vol. 43, No. 7 3) The Glymphatic System in
Central Nervous System Health and Disease: Past, Present, and Future/PM13CH15_Nedergaard ARI 16 November
ANATOMIA GLINFATICA:
ESPACIO PERIVASCULAR Y LAMINA BASAL

1) The role of brain barriers in fuid movement in the CNS: is there a ‘glymphatic’ system? /Acta
Neuropathologica (2018) 135:387–407/
¿ESPACIO PERIVASCULAR DESAPARECE?

1) The Glymphatic System: A Beginner’s /GuideNeurochem Res (2015) 40:2583–2599 2) The Brain’s Glymphatic
System: Current Controversies/Trends in Neurosciences, July 2020, Vol. 43, No. 7 3) The Glymphatic System in
Central Nervous System Health and Disease: Past, Present, and Future/PM13CH15_Nedergaard ARI 16 November
¿ESPACIO PERIVASCULAR DESAPARECE?

1) The Glymphatic System: A Beginner’s /GuideNeurochem Res (2015) 40:2583–2599 2) The Brain’s Glymphatic
System: Current Controversies/Trends in Neurosciences, July 2020, Vol. 43, No. 7 3) The Glymphatic System in
Central Nervous System Health and Disease: Past, Present, and Future/PM13CH15_Nedergaard ARI 16 November
¿EL PULSO CARDIACO CONDUCE AL LCR AL E.PV?

1) Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension/ NATURE
COMMUNICATIONS | (2018) 9:4878 2) The Brain’s Glymphatic System: Current Controversies/Trends in
Neurosciences, July 2020, Vol. 43, No. 7 3) The Glymphatic System in Central Nervous System Health and Disease:
¿HIPERTENSION, FACTOR DE RIESGO PARA ALZHEIMER?

1) Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension/ NATURE
COMMUNICATIONS | (2018) 9:4878 2) The Brain’s Glymphatic System: Current Controversies/Trends in
Neurosciences, July 2020, Vol. 43, No. 7 3) Impaired Glymphatic Transport in Spontaneously Hypertensive Rats. J
Neurosci. 2019 Aug 7;39(32):6365-6377.
 FLUJO “ A GRANEL” Y AQP4

AQP4 – 60%
B AMILOIDE

1) Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife. 2018 Dec 18;7:e40070 2) The
Brain’s Glymphatic System: Current Controversies/Trends in Neurosciences, July 2020, Vol. 43, No. 7 3) The
Glymphatic System in Central Nervous System Health and Disease: Past, Present, and
.

CIRCUITO
INTEGRAD
O
1) Implications of the discovery of brain lymphatic pathways/ www.thelancet.com/neurology Vol 14 October
.

CIRCUITO
INTEGRAD
O
1) The Glymphatic System: A Beginner’s /GuideNeurochem Res (2015) 40:2583–2599 2) The Brain’s Glymphatic
System: Current Controversies/Trends in Neurosciences, July 2020, Vol. 43, No. 7 3) The Glymphatic System in
Central Nervous System Health and Disease: Past, Present, and Future/PM13CH15_Nedergaard ARI 16 November
 ¿FALTA DE SUEÑO COMO FACTOR A
ALZHEIMER?

1)) The Brain’s Glymphatic System: Current Controversies/Trends in Neurosciences, July 2020, Vol. 43, No. 7 2) The
Glymphatic System in Central Nervous System Health and Disease: Past, Present, and
Future/PM13CH15_Nedergaard ARI 16 November 2017 3) Brain aging and garbage cleaning Modelling the role of sleep,
¿FALTA DE SUEÑO COMO FACTOR A
ALZHEIMER?

1))all you need is sleep in focus| volume 12, p2-3, october 01, 2016

 FLUJO “ A GRANEL” Y AQP4

1) Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife. 2018 Dec 18;7:e40070 2) The
Brain’s Glymphatic System: Current Controversies/Trends in Neurosciences, July 2020, Vol. 43, No. 7 3) The
Glymphatic System in Central Nervous System Health and Disease: Past, Present, and
 ¿ ALTERACIONES EN EL FLUJO POR LA EDAD?

1) The Glymphatic System: A Beginner’s /GuideNeurochem Res (2015) 40:2583–2599 2) The Glymphatic System and
Waste Clearance with Brain Aging: A Review/Gerontology 2019;65:106–119
 SENESENCIA ASTROCITICA Y APO E

1) The Glymphatic System: A Beginner’s /GuideNeurochem Res (2015) 40:2583–2599 2) Astroglial asthenia
and loss of function, rather than reactivity, contribute to the ageing of the brain/Pflügers Archiv - European
Journal of Physiology; 26 september 2020
 ALZHEIMER Y APO E

1) The Glymphatic System: A Beginner’s /GuideNeurochem Res (2015) 40:2583–2599 2) Astroglial asthenia
and loss of function, rather than reactivity, contribute to the ageing of the brain/Pflügers Archiv - European
Journal of Physiology; 26 september 2020
 ACUMULACIONES
NEURODEGENERATIVAS

1) The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and
Future/PM13CH15_Nedergaard ARI 16 November 2017 2) Suppression of glymphatic fluid transport in a
mouse model of Alzheimer’s disease/Neurobiology of Disease 23 May 2016
 ACUMULACIONES
NEURODEGENERATIVAS

1) The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and
Future/PM13CH15_Nedergaard ARI 16 November 2017 2) Suppression of glymphatic fluid transport in a
mouse model of Alzheimer’s disease/Neurobiology of Disease 23 May 2016
 ACUMULACIONES
NEURODEGENERATIVAS

1) The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and
Future/PM13CH15_Nedergaard ARI 16 November 2017 2) Suppression of glymphatic fluid transport in a
mouse model of Alzheimer’s disease/Neurobiology of Disease 23 May 2016
 ALZHEIMER: ¿EL SISTEMA GLINFATICO
HA FALLADO?

1) Glymphatic failure as a final common pathway to dementia/Science  02 Oct

2020: Vol. 370, Issue 6512, pp. 50-56