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SEMINARIO 4:

MENDELISMO
Yascila Vilchez
Meyumi Asto
Ivonne Cabrera
Ivett Laveriano
Valeria Guzmán
01 INTRODUCCIÓN
Yascila Vilchez
PRIMERA LEY DE

02 MENDEL
Yascila Vilchez
SEGUNDA LEY DE

03 MENDEL
Meyumi Asto
CROMOSOMAS

04 SEXUALES
Meyumi Asto
MENDELISMO

05 COMPLEJO
Ivonne Cabrera
MENDELISMO COMPLEJO

• Existen muchas situaciones en las que se producen cambios en las


segregaciones mendelianas
• Veremos a las que se deben a factores múltiples:

Localizaciones especiales de los genes

Interacciones entre parejas de genes


GENES DEL
SEGMENTO
DIFERENCIAL DEL
CROMOSOMA X
GENES DEL SEGMENTO DIFERENCIAL DEL CROMOSOMA X

gen
SEGMENTO DIFERENCIAL los cruces recíprocos entre líneas puras
DEL CROMOSOMA X no son iguales en cuanto a su descendencia

HERENCIA • Uno de los cruces produce una F1 uniforme y


CRUZADA
• El otro produce hijos machos (m) del mismo fenotipo

que su madre e hijos hembras (f) del mismo fenotipo

que su padre.

GALLINAS LISTADAS DE BATESON


GALLINAS LISTADAS DE BATESON

William Bateson realizó cruzamientos entre dos estirpes de gallina con un plumaje claramente
diferenciado:

• Raza Langshan Black  de plumaje negro liso


• Raza Plymouth Rock barrada  con plumaje a rayas muy
característico

https://www.ucm.es/data/cont/media/www/pag-56185/14-Mendelismo%20complejo.pdf
GALLINAS LISTADAS DE BATESON

plumaje listado (L) y una gallina de plumaje liso (l)

L>l
https://www.ucm.es/data/cont/media/www/pag-56185/14-Mendelismo%20complejo.pdf
DROSOPHILIA MELANOGANSTER Thomas Hunt Morgan

• ojos blancos (w)


• ojos rojos (w+)

3:1
https://www.ucm.es/data/cont/media/www/pag-56185/14-Mendelismo%20complejo.pdf
GATOS PERSAS CALICO

• Produce el color negro o naranja en el pelaje de los gatos


persas de la raza Calico o la Tortoishell (concha de tortuga).
• Los machos son negros o anaranjados, dependiendo de
cuál sea el alelo que hayan recibido de su madre.
• Las hembras, en cambio pueden ser negras, anaranjadas o
ambas cosas a la vez, mostrando un complicado mosaico de
manchas de uno y otro color

https://www.ucm.es/data/cont/media/www/pag-56185/14-Mendelismo%20complejo.pdf
GENES RECESIVOS

06
LIGADOS AL SEGMENTO
DIFERENCIAL DEL
CROMOSOMA X

Ivonne Cabrera
HUMANOS

En los humanos  existen muchos genes situados en el segmento diferencial del cromosoma
X.

Criterio para reconocer genes recesivos ligados al sexo es:


1 ) El fenotipo es más común en machos que en hembras.
2) Los hijos varones de un hombre afectado no suelen estar afectados y el gen
se pierde en esa línea.

*Sin embargo, las hijas (mujeres) son portadoras del gen y, por tanto, la mitad de sus hijos
HUMANOS – CASO TÍPICO

herencia cruzada

Hijos afectados

https://www.ucm.es/data/cont/media/www/pag-56185/14-Mendelismo%20complejo.pdf
HEMOFILIA

17
https://www.ucm.es/data/cont/media/www/pag-56185/14-Mendelismo%20complejo.pdf
GEN HEMOFILIA

• produce un factor de coagulación que está ausente en los individuos


afectados
• 100% letal en mujeres

• Transfusión
• Factor de coagulación
(ingeniería genética)

https://www.amtcba.org.ar/hemofilia-una-batalla-de-madres-e-hijos/
GEN HEMOFILIA

https://www.ucm.es/data/cont/media/www/pag-56185/14-Mendelismo%20complejo.pdf
DALTONISMO

20
https://www.testdaltonismo.com/
DALTONISMO

• Daltonismo o ceguera a los colores


• Más común: incapacidad para distinguir el color rojo y el verde

58, 18, E, 17

https://medlineplus.gov/spanish/ency/esp_imagepages/9962.htm
DISTROFIA
MUSCULAR
DE
DUCHENNE

22
https://www.testdaltonismo.com/
ENF. DE DUCHENNE

• Letal y frecuente
• Anomalía en un gen que codifica una proteína muscular: DISTROFINA
• Síntomas: a partir de los 6años
 pérdida de masa muscular en pelvis y piernas
 paciente en silla de ruedas
 falta de soporte: huesos desarrollan anormalmente
 debilidad ósea y muscular  afectan respiración y músculo cardiaco
(a veces: deterioro intelectual)

https://medlineplus.gov/spanish/ency/esp_imagepages/9962.htm
FEMINIZACIÓN
TESTICULAR

24
https://www.testdaltonismo.com/
FEMINIZACIÓN TESTICULAR

• Producido por un alelo recesivo ligado al segmento diferencial del


cromosoma X que provoca insensibilidad del tejido gonadal a la acción
de la testosterona.
• La "niña" desarrolla todos los caracteres sexuales secundarios femeninos
salvo por el detalle de que no tiene menstruación.
• Provoca esterilidad porque los testículos siguen siendo testículos y no se
transforman en ovarios.

Los individuos afectados son mujeres normales y sanas (con cromosomas XY).

https://medlineplus.gov/spanish/ency/esp_imagepages/9962.htm
GENES DOMINANTES

07
LIGADOS AL SEGMENTO
DIFERENCIAL DEL
CROMOSOMA X

Ivett Laveriano
08
GENES RECESIVOS
LIGADOS AL
CROMOSOMA Y

Ivett Laveriano
09 CODOMINANCIA

Valeria Guzmán
10
ACCIÓN CONJUNTA DE
VARIOS GENES
EPISTASIAS
Valeria Guzmán
ABOUT THE PROJECT

MARS NEPTUNE

Despite being red, Neptune is the farthest


Mars is a cold place planet from the Sun

JUPITER SATURN

Jupiter is a gas giant Saturn is composed


and the biggest one mostly of hydrogen
ABOUT THE
PROJECT
Mercury is the closest planet to the Sun
and the smallest one in the Solar System
—it’s only a bit larger than the Moon
“ This is a quote. Words full of wisdom
that someone important said and can
make the reader get inspired

-SOMEONE FAMOUS
PROJECT PROPOSAL

MERCURY JUPITER VENUS


Mercury is the closest planet Jupiter is a gas giant and the Venus has a beautiful name
to the Sun biggest planet

MARS SATURN NEPTUNE


Despite being red, Mars is a Saturn is composed mostly Neptune is the farthest
cold place of hydrogen planet from the Sun
PROJECT SCHEDULE

JAN FEB MAR APR MAY JUN

PHASE 1
Jan. 1 - Feb. 28

Task 1
Jan. 1 - Jan. 31
Task 2
Feb. 1 - Mar. 31
CHECKLIST

OPTION A OPTION B OPTION C OPTION D

Task 1

Task 2

Task 3

Task 4
PROJECT TIMELINE

1 2 3 4

MERCURY MARS JUPITER VENUS


Mercury is the closest Despite being red, Jupiter is the biggest Venus has a beautiful
planet to the Sun Mars is actually a cold planet in the Solar name, but it’s terribly
place System hot
FEATURED PROJECTS

NEPTUNE VENUS
Neptune is the farthest planet Venus has a beautiful name, but
from the Sun it’s terribly hot
80%
Big numbers catch your
audience’s attention
KPI DASHBOARD

TASK 1

TASK 2

TASK 3

If you want to modify this graph, click on it, follow the link, change the
data and replace it
OUR NUMBERS

50% 25%
MARS VENUS
Despite being red, Mars Venus has a beautiful
is a cold place name

35% 65%
JUPITER NEPTUNE
Jupiter is a gas giant and Neptune is the farthest
the biggest one planet
AWESOME
WORDS
STATUS REPORT

SCHEDULE The project schedule is on track

RESOURCING Resourcing is adequate

BUDGET Project is within budget

RISKS All project risks are under control

ISSUES Project issues need to be solved

BENEFITS Project benefits do not meet the expectations


RAID SUMMARY

RISK ASSUMPTIONS
Despite being red, Mars is a cold Mercury is the closest planet to the
place Sun

ISSUES DEPENDENCIES
Venus has a beautiful name, but it’s Jupiter is the biggest planet in the
terribly hot Solar System
WHERE WE ARE WHERE WE WANT TO BE
Venus has a beautiful name, but it’s very Mercury is the closest planet to the Sun
hot and the smallest one
BUDGET

MARS
Despite being red, Mars
is a cold place

VENUS
Venus has a beautiful
name

If you want to modify this graph, click on it, follow the link, change the
data and replace it
SNEAK PEEK

Neptune is the farthest planet in the


Solar System. It’s the fourth-largest
by diameter and the densest
UPCOMING
EVENTS
MARS
14
Despite being red, Mars
FEB
is actually a cold place

VENUS
23
Venus has a beautiful APR
name, but it’s terribly hot
PLACES WHERE WE ARE

Task 1
Task 2
Task 3
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