FAGOCITOSIS

Santiago Martinez & Maria Jose Matulanda

 TABLA DE CONTENIDO
1. Introduccion
2. Funciones más importantes
3. Células de capacidad fagocitica
4. Etapas de la fagocitosis (Quimiotaxis)
5. Moléculas de capacidad quimiotáctica
● Neutrofilos
● Monocitos y macrofagos
● Eosinofilos y celulas dendriticas
1. Moléculas de adhesión al endotelio (selectinas)
● Integrinas
1. Moleculas de activacion celular
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 TABLE OF CONTENTS

OBJECTIVES METHODOLOGY
01 You can describe the topic of the 02 You can describe the topic of the
section here section here

RESULTS ANALYSIS CONCLUSIONS

03 You can describe the topic of the
04 You can describe the topic of the
section here section here
 INTRODUCCION
¿Que es la fagocitosis?
Proceso por el cual ciertas células y organismos unicelulares
capturan y digieren partículas nocivas o alimento.
 FUNCIONES MÁS
IMPORTANTES
01 Entre las funciones más importantes de la fagocitosis se
encuentran; la destrucción del microorganismo, el
remodelamiento de órganos, la eliminación o remoción de
complejos inmunes y otras moléculas, junto con la reparación
tisular.
 DESTRUCCIÓN DEL
MICROORGANISMO
Disminución de intensidad por desaparición a través de las
células fagocíticas

REMODELAMIENTO DE
ÓRGANOS
Macrófagos de cuerpo tingible, hacen recambio celular
FUNCIONES
eliminando las células muertas
MÁS
REMOCIÓN DE IMPORTANTES
COMPLEJOS INMUNES
Relacionado con enfermedades autoinmunes (lupus
eritematoso sistémico)

REPARACION TISULAR
Posterior al proceso inflamatorio, restablece la
funcionalidad del tejido u órgano
CÉLULAS DE CAPACIDAD FAGOCITICA

PROFESIONALES NO PROFESIONALES
Ingieren el antígeno o Ingieren el antígeno o microorganismo, y
microorganismo, y lo eliminan no lo eliminan

Neutrofilos, Macrofagos y Celulas dendriticas Fibroblastos, epitelio y células endoteliales

CELULAS FAGOCITICAS PROFESIONALES

NEUTROFILOS CELULAS DENDRITICAS

Son importantes por la cantidad Única capaz de activar linfocitos
de células que eventualmente la T, importante para la formación de
médula ósea puede producir, y memoria inmunológica,
por el hecho de poder generación de mecanismo
localizarse en el tejido MACROFAGOS efectores más efectivos
Células que se pueden
autorrenovarse, luego de que
se han de granulado
 ETAPAS DE LA FAGOCITOSIS

QUIMIOTAXIS

Mecanismo mediante el cual una

molécula (producida por el sistema
inmune o por un microorganismo)
atrae células de una manera
unidireccional
MOLÉCULAS DE
CAPACIDAD
QUIMIOTÁCTIC
A
 NEUTROFILOS

CXCR1 CXCR2 / CXCR5 LEUCOTRIENO B4

CXCL6 (GCP-2), CXCL7, CXCL1- CXCL2- CXCL3, Producto del ácido araquidónico vía
IL-8 (CXCL8) CXCL5- CXCL6, CXCL7,8 ciclooxigenasa

PEPTIDOS fMLP C5aR PAF

Formilo, metionina, lisina y
C5a Factor activador de plaquetas
fenilalanina
 MONOCITOS Y MACROFAGOS

CCR1 CXCR4
CCL3, CCL3LI, CCL5, CCL7,
CCL13, CCL14-16 (HCC-1 al SDF-1 alfa y beta (CXCL12)
4) CCL23(MPIF-1)

CCR2 CCR8
MCP-1 al 4, (CCL2, CCL8, factor I 309(CCL1) y el
CCL7, CCL13) CCL7

CCR5 C1qR - CXCR1

MCP 1 al 4, MIP 1beta
surfactante A y D reconocido
(CCL4), CCL3, CCL13LI,
por el C1qR, y el CXCL2
RANTES (CCL5) MCP-2
reconocido por la CXCR1
(CCL8)
 MOLÉCULAS QUIMIOTÁCTICAS

EOSINOFILOS CELULAS DENDRITICAS

QUIMIOQUINA RECEPTOR
QUIMIOQUINA RECEPTOR
C3a C3aR
CCL20 CCR6
RANTES (CCL5) CCR1, CCR3
CCL22 CCR4
MIP-1a CCR3, CCR5
CCL 19, CCL21 CCR7
MCP-3 CCR2, CCR5
CXCL12 CXCR4
Eotaxina, eotaxina
2 y 3 (CCL11, 24 CCR3
Y 26)
 MOLÉCULAS DE ADHESIÓN AL
ENDOTELIO
SELECTINA P SELECTINA L SELECTINA E
Reconoce
Estimulada por
glucosaminoglicanos
SELECTINAS histamina, el leucotrieno
sulfatados, CD34 y el
Interviene por la acción
B4, (TNF-a), la C5a de la IL-1, TNF-a, IFN-Y
MadCAM-1,
 INTEGRINAS

ICAM2 JAM
Disminuye las uniones
LFA-1 cohesivas producidas entre las
células

ICAM 1 PCAM
MAC 1, LFA-1, Endotelio vascular, plaquetas,
monocitos, neutrófilos y
algunos tipos de linfocitos T
MOLECULAS DE ACTIVACION CELULAR
● La adenilciclasa va a ser muy importante ya que va a activar el
AMPc la cual junto con diferentes tipos de enzimas va a
llevar a la activación de 3 moléculas que son la actina, la
miosina, y la tubulina
● Liberación de enzimas; Concomitantemente con este proceso
de quimiotaxis haya un proceso inflamatorio que favorece la
migración de estas células y genera un mecanismo de
transporte
● Reconocimiento del antígeno: Manera directa o indirecta
● Manera directa reconocimiento no opsónico
● Manera directa reconocimiento opsónico
 RECONOCIMIENTO NO OPSÓNICO

MOLECULAS PAMS
● Lipopolisacarido
● acido lipoteicoico
● peptidoglicano Péptidos diacilados y
● lipoproteínas generadas triacilados, la proteína F, el
por palmitilacion Niquel. El Zimosan, los
● Cisteínas N-terminal, Mananos y beta-glucanos
● Lipoarabinomano
● Ds ARN
 MOLÉCULAS RECEPTORES DE
RECONOCIMIENTO DE PAMS
LDL-Acetilado
RECEPTORES Lipopolisacarido
TLR BASURERO Acido lipoteicoico
Poly IC
TLR 1, 2, 4, 5 Y Glicoproteina de Fosfatidil serina
6 (De membrana Lipopeptidos
membrana) diacilados
Tipos Gas-6, MFG-E8 ATP
TLR 3, 7 Y 9 SR-A ~ SR-BI/BII ~ Lisofosfatidil
(Membrana MARCO ~ CD36 ~ Fractalkina
endosomica) CD14 ~ CD68 ~ Esfinfosina 1 P
Calreticulina ~ CD91
 DAMPS

Proteínas del grupo 1 de alta

movilidad, proteínas de shock
térmico (HSP 90), fragmentos de
acido hialuronico, versican que es
un proteoglicano presente a nivel
de la matriz extracelular (también
se le llama condroitin sulfato),
Tenascina C, componente serico
amiloide, lípidos asociados con
anillos pirrólicos (CEP) y
fibrinogeno
 OBJECTIVES
01 You can describe the topic of the section here
AWESOME
WORDS
A PICTURE IS WORTH A
THOUSAND WORDS
 GOALS

R. de manosa • Ayuda en fagocitosis de

de los bacterias
macrófagos • Reconocimiento de hongos

• Dectina 1-2
• Acción del LTh-17
R. de β • Producción de IL-17
glucanos • Reconocimiento cimosan
• TLR-2
 Moléculas que permiten la entrada de
microorganismos a células
Microorganismos
Receptor del penetran en la
CR3
complemento
Patogenicidad
célula
(Macrófago)

Permite la
N.
CD66 reproducción Opa-52
Gonorrhoae
de

• Trombospondina
Reconocidas
• Vitronectina
αVβ3 por Bordetela,
• PMN
α5β1 Coxiela, CD36
Histoplasma Puede ser reconocido
por: Plasmodium
falciparum
Moléculas
opsónicas
 Colectinas

P. Unidora

receptores de membrana
de manosa

UNIÓN A CÉLULAS

Reconocimiento de
C1qrp y Cr1

FAGOCITICAS
Carbohidratos
Surfactante
AyD presentes en Gp340
microorganismos

C1qrp y C1qGr
C1q
 Proteína C reactiva y componente sérico
amiloide

● Pentraxinas

● Fosforilcolina, cromatina, histonas,

ribonucleoproteinas y fibronectina

● Posteriormente estas moléculas van a ser

reconocidas por los receptores FC ϫ I, II
 Proteína unidora del lipopolisacárido

● Para que el LPS sea reconocido no solo

se requiere el LBP:

● CD14 y MDY88
● TLR-4
 Anticuerpos
Macrófago:
receptor para
IgG
IgG También
Neutrófilo receptores Ambos con
Ac. clave puede llegar a dos
reconocimiento expresar FC ϫ FC ϫ II y FC ϫ isomorfos
de Ags y I III
opsonización

IgA
Células Monocitos
expresan
receptor FCα Neutrófilos
 C1q
Interactúa con fosfolipidos de memb.
del microorganismo

C3b
Cr1, Cr2, Cr3, Cr4 Moléculas del
C3C/D/DG complemento
Capacidad de opsonización
disminuida

C4B
Cr1, Cr2, Cr3, Cr4
Internalización del
antígeno
Factor sensible a la N-etilmaleimida
V-Snare, proteínas Rab
“This is a quote, words full of wisdom that
someone important said and can make the
reader get inspired.”
—SOMEONE FAMOUS
 METHODS

OBSERVATION STUDY
Saturn is a gas giant with Mars is actually a very cold
several rings place

SAMPLING DATA
Mercury is the closest planet Neptune is far away from
to the Sun Earth

HYPOTHESIS EXPERIMENTS
Jupiter is the biggest planet Venus is the second planet
of them all from the Sun
RESEARCH AND PUBLICATIONS

It’s the closest planet to the Venus has a beautiful name

Sun and the smallest one in the and is the second planet from
Solar System the Sun

BY MERCURY BY VENUS
RESEARCH RESOURCES

● You can list you reference website or publications here

● You can list you reference website or publications here
● You can list you reference website or publications here
● You can list you reference website or publications here
● You can list you reference website or publications here
● You can list you reference website or publications here
 SATURN
It’s composed of hydrogen
and helium

MERCURY
It’s the closest planet to the
Sun FACTORS TO
JUPITER CONSIDER
Jupiter is the biggest planet of
them all

MARS
Despite being red, Mars is a
cold place
 CLINICAL TRIAL

PRECLINICAL PHASE 1 PHASE 2 PHASE 3

Lab studies Human safety Expanded safety Efficacy & safety
 TRIAL TIMELINE

PRECLINICAL RESULT
Mercury is the closest planet to Mars is actually a very cold
the Sun place

RESEARCH EXPERIMENTS CONCLUSIONS

Jupiter is the biggest planet of Neptune is the farthest planet Saturn is composed of
them all from the Sun hydrogen and helium
 ANTIBIOTIC RESISTANCE

STEP 01 STEP 02
You can describe the topic of the You can describe the topic of the
section here section here

Non resistant bacteria Resistant bacteria Antibiotic

 PHASE 1

GOAL
Neptune is the farthest planet
from the Sun 60%
EFFECTS Earth is the third planet from
Saturn is composed of the Sun
hydrogen and helium

50% RESULTS
MERCURY 1 YEAR Jupiter is the biggest
Venus is the second planet planet of them all
It’s the closest planet to the
Sun from the Sun
 TREND
2010
Saturn is composed of
hydrogen and helium

2015
Mercury is the closest planet
to the Sun

2020
Jupiter is the biggest planet
of them all

Follow the link in the graph to modify its data and then paste the new one here. For more info, click here
A PICTURE
ALWAYS
REINFORCES THE
CONCEPT
Images reveal large amounts of data, so
remember: use an image instead of a long
text. Your audience will appreciate it
 RESULTS

EXPERIMENT A EXPERIMENT B
TREATMENT TEST 1 TEST 2 TEST 3 TREATMENT TEST 1 TEST 2 TEST 3

GROUP 1 254 368 356 GROUP 1 135 376 786

GROUP 2 127 456 587 GROUP 2 564 238 536

GROUP 3 112 453 125 GROUP 3 542 764 786

STUDIES BY AREAS

SATURN
It’s composed of hydrogen
and helium

JUPITER
Jupiter is the biggest planet
of them all
 RESULTS ANALYSIS

50% 50%
Earth is the third planet from Venus is the second planet
the Sun from the Sun

MERCURY SATURN
It’s the closest planet to the It’s composed of hydrogen
Sun and helium
150,000
Big numbers catch your audience’s attention
 50%
Percentages are useful

70%
Percentages are useful

85%
Percentages are useful
CONCLUSIONS

Venus has a beautiful name and is

the second planet from the Sun. It’s
terribly hot, even hotter than
Mercury, and its atmosphere is
extremely poisonous. It’s the
second-brightest natural object in
the night sky after the Moon
MOCKUP
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