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Bioquímica

ENCEFALOPATÍAS
ESPONGIFORMES
Paula R., Adrián R., Bruno R., Álvaro R., Laura R., Alba R., César R.
Detección de la enfermedad
Enfermedad de Creutzfeldt-Jakob - 1995

TRANSMISIÓN

Horizontal Vertical
Otras
Ingestión de alimentos Madre - hijo
-Escarificaciones
contaminados -Trasplante de
10%
tejidos
Ej.: Scrapie -Inoculación
Inespecíficos Específicos

-Pérdida de la condición física - Descoordinación de


-Cojeras movimientos.
-Disminución de la coordinación - Cambios de
comportamiento.
- Nerviosismo.
Síntomas - Respuestas
exageradas a ruidos o
luces habituales.
- Recelo y
agresividad.
Se vuelven muy llamativos en las últimas fases de la
- Muerte.
enfermedad, haciendo que se conozca como
“La enfermedad de las vacas locas”.
Tipos de análisis :
Pruebas de diagnóstico rápido:
● Detección de proteína priónica resistente a la proteinasa K de las Encefalopatías
Espongiformes Transmisibles por inmunotransferencia.

● Detección de proteína priónica patógena de las Encefalopatías Espongiformes


Transmisibles por Inmunoensayo de doble anticuerpo.

● Detección de proteína priónica patógena de las Encefalopatías Espongiformes


Transmisibles por Inmunoensayo de captura utilizando un polímero químico
(Protocolo estándar y el más corto).
Tipos de análisis :
Pruebas de confirmación:
● Western blot de confirmación
● Histopatología
● Inmunohistoquímica

Pruebas de discriminación:
● Método de la técnica híbrida del AHVLA para Scrapie clásico y encefalopatía
espongiforme bovina (EEB) en ovino/caprino.
● Método CEA Scrapie clásico, atípico y EEB en ovino/caprino.
● Método AHVLA híbrido
● Método Western blot híbrido para EEB clásica, EEB-High y EEB-Low
Objetivos de estos análisis
1. Detectar la aparición de casos de variante de ECJ.

2. Detectar la aparición de casos transmitidos accidentalmente.

3. Conocer el perfil clínico-epidemiológico de estas enfermedades.

4. Monitorizar su presencia en España y estudiar su distribución.

5. Identificar posibles factores de riesgo.

6. Establecer comparaciones epidemiológicas con otros países( Reino Unido).


Introduction
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01
Properties
of matter
You can enter a subtitle here if you need it
Features of matter

Mass Volume Weight


It’s the closest planet to Venus is the second Mars is actually a very
the Sun planet from the Sun cold place

Porosity Inertia Impenetrably


Jupiter is the biggest It’s composed of It’s the farthest planet
planet of them all hydrogen and helium from the Sun
A picture is worth a
thousand words
States of matter

Solid Liquid Gas


It’s the closest planet to Venus has a beautiful Despite being red, Mars is
the Sun and the smallest in name and is the second actually a cold place. It’s
the Solar System planet from the Sun full of iron oxide dust
Chemistry evolution in our history

1 2 3 4

2000 B.C 1709 1954 2004


Despite being red, Jupiter is the It’s composed of Venus is the second
Mars is a cold place biggest planet hydrogen & helium planet from the Sun
The matter conceptual map

Matter

Extrinsic Intrinsic

Mass Weight Density Boiling


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Mercury is the closest It’s actually a cold place.
planet to the Sun It’s full of iron oxide dust
Periodic table
1 2
H He
3 4 5 6 7 8 9 10
Li Be B C N O F Ne
11 12 13 14 15 16 17 18
Na Mg Al Si P S Ci Ar
19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36
K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr
37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54
Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe
55 56 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86
Cs Ba Lu Hf Ta W Re Os Ir Pt Au Hg Ti Pb Bi Po At Rn
87 88 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
Fr Ra Lr Rf Db Sg Bh Hs Mt Ds Rg Cn Nh Fi Mc Lv Ts Og
57 58 59 60 61 62 63 64 65 66 67 68 69 70
La Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb
89 90 91 92 93 94 95 96 97 98 99 100 101 102
Ac Th Pa U Np Pu Am Cm Bk Cf Es Fm Md No
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02
Reactions
of elements
You can enter a subtitle here if you need it
The most important reactions

Fission Fusion
Mercury is the closest planet to Venus has a beautiful name and
the Sun and the smallest one in is the second planet from the
the Solar System—it’s only a bit Sun. It’s hot and has a
larger than the Moon poisonous atmosphere
Household dangerous chemicals

Product 1 Product 2 Mix Reaction


Bleach Ammonia Is a dwarf planet

Bleach Water The Sun is a star

Bleach Vinegar Saturn is a gas giant

Bleach Alcohol Mars is cold


150,000
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This is a map for you

Mars
It’s actually a cold place.
It’s full of iron oxide dust

Mercury
Mercury is the closest
planet to the Sun
Write here the results

Result 1 Result 2

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These are some percentages

35% 85% 65%


Despite being red, It’s the farthest Venus is the second
Mars is a cold place planet from the Sun planet from the Sun
03
Nuclear
fusion
You can enter a subtitle here if you need it
Benefits of electrostatic confinement

Stadiness Electric field


Venus is the second It’s the biggest planet in
planet from the Sun the Solar System

Ionization Energy
Despite being red, Mars Saturn is a gas giant and
is a cold place has several rings
Awesome
words
A picture always
reinforces the
concept
Images reveal large amounts of data,
so remember: use an image instead
of a long text. Your audience will
appreciate it
This is a graph

100 m²
Venus is the second planet

50 km
Mars is a cold place

25
Saturn is a gas giant

Follow the link in the graph to modify its data and then
paste the new one here. For more info, click here
9h 55m 23s
Is Jupiter's rotation period

333,000.000
Earths is the Sun’s mass

386,000 km
Is the distance between Earth and the Moon
Our team

Jenna Doe Timmy Jimmy Beth Bones


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