NEUROBIOLO

GÍA DE LAS
BENZODIACE
Lorena Figueroa Buitrago y Diana Carolina

PINAS Libreros
HISTORIA DE LAS BENZODIACEPINAS

Siglo 19 1960
Bromuros Clordiazepóxi
do - Diazepam

Bíblicos 1903 Boom 70’

Alcohol Barbitúricos ansiedad, insomnio,
agitación, crisis,
espasmos, anestesia

Dubovsky SL, Marshall D. Benzodiazepines Remain Important

Therapeutic Options in Psychiatric Practice. Psychother
Psychosom. 2022;91(5):307-334. doi: 10.1159/000524400. Epub
2022 May 3. PMID: 35504267.
 triazolo

Epileptic Disord
2016; 18 (3): 217-27

imidazo
 PAMs. Propician los potenciales
postsinápticos fásicos. Usadas como
hipnóticos, ansiolíticos, anticríticos,
relajantes musculares y en el
tratamiento de la abstinencia a OH

Goldschen-Ohm, M.P. Benzodiazepine Modulation of GABAA Receptors: A Mechanistic Perspective.

Biomolecules 2022, 12, 1784. https://doi.org/10.3390/biom12121784
 FARMACOCIN
01 ÉTICA
Vida media, potencia, metabolismo,
interacciones medicamentosas
 Generalidades farmacocinéticas

● Presentaciones: oral, IM,

rectal, IV, bucal e intranasal
● Absorción oral completa y
niveles pico en 30 - 120 min
● Liposolubilidad alta
determina la distribución y el
efecto
● Unión a proteínas 70-99%

Dubovsky SL, Marshall D. Benzodiazepines Remain Important Therapeutic Options in Psychiatric Practice.
Psychother Psychosom. 2022;91(5):307-334. doi: 10.1159/000524400. Epub 2022 May 3. PMID: 35504267.
Potencia
biotransformación
1. N-desalquilación (exc.
triazolam, alprazolam
y midazolam)
2. Hidroxilación
3. Conjugación con
ácido glucorónido

→ CYP3A4 y CYP2C19

Bounds CG, Nelson VL. Benzodiazepines. [Updated temazepa

2023 Jan 7]. In: StatPearls [Internet]. Treasure Island
(FL): StatPearls Publishing; 2023 Jan-. Available from:
m
https://www.ncbi.nlm.nih.gov/books/NBK470159/
 PRESENTACIONES: MIDAZOLAM 0.1-0.3
Biodisponibilida Inicio de mg/kg
Vida media Metabolismo Excreción
d acción
36% VO - 90% IM 5-15 minutos 1.5-2.5 horas (corta) CYP3A4 (alpha-1 Renal
hydroxy
midazolam 10%)

GABA-AR y Gly-R.
Nasal, oral, IM, IV.
Indicaciones: Sedación
en paciente intubado, Lingamchetty TN, Hosseini
SA, Saadabadi A.
agitación, status Midazolam. [Updated 2023
convulsivo Feb 12]. In: StatPearls
[Internet]. Treasure Island
Ojo: anfipático según (FL): StatPearls Publishing;
2023 Jan-. Available from:
pH, alta tolerancia) https://www.ncbi.nlm.nih.g
ov/books/NBK537321/
 PRESENTACIONES: triazolam 0.125-0.5 mg
Biodisponibilid Cmax Vida media Metabolismo Excreción Categoría
ad embarazo

99-100% 2 horas 1,5-5,5 horas CYP3A4, Renal: en forma D

(corta) unión a de metabolitos
proteínas 80-
90%

Indicaciones:
Insomnio de
conciliación (uso
transitorio por máx 2
ss)

Capítulo 17. Hipnóticos y sedantes.». Goodman & Gilman. Las bases farmacológicas de la terapéutica. New York: McGraw-Hill.
 PRESENTACIONES: alprazolam (0.25-5/10
Biodisponibilid Inicio de Vida mediamg)
Metabolismo Excreción Categoría
ad acción embarazo

90% 5-10 6-15 horas CYP3A4, Renal: 4- D

minutos. (intermedia) unión a hidroxalprazolam
Cmáx 2 h proteínas 80% α-
hidroxalprazolam
Indicaciones:
Trastorno de
pánico con o
sin agorafobia,
trastornos de
ansiedad

George TT, Tripp J. Alprazolam. [Updated 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK538165/
 PRESENTACIONES: lorazepam (0.5-10 mg)
Biodisponibilida Cmáx Vida media Metabolismo Excreción
d

90% 2 horas 10-20 horas Glucoronización Renal

(intermedia) . 90% unión a
proteínas

Indicaciones: trastorno
de ansiedad (4 m),
status convulsivo
(American Epilepsy
Society guidelines)
miorreajante, SNM,
abstinencia OH
 PRESENTACIONES: mexazolam (1-3 mg)
Biodisponibilida Interacción Vida media Metabolismo Excreción
d especial
90% Estatinas Distribución bi- CYP3A4 y CYP2C11 90% fecal,
(excepto compartimental: 1 (chloronordiazepam y 10% renal
pravastatina) - 76 horas (larga) chloroxazepam+), unión a
proteínas 90%

Indicaciones: trastornos
de ansiedad

Fernandes, H., & Moreira, R. (2014). Mexazolam: clinical

efficacy and tolerability in the treatment of anxiety. Neurology
and Therapy, 3, 1-14.
 PRESENTACIONES: clonazepam (0.5-8 mg)
Biodisponibilid Inicio de Vida media Metabolismo Excreción Clase
ad y pico acción embarazo
plasmático
90% / 1-4 horas 20-60 minutos 30-40 horas CYP3A4, unión a Renal D
(larga) proteínas 85%
Indicaciones:
Trastorno de pánico,
epilepsia mioclónica y
de ausencia, EP no
convulsivo. Otros:
síndrome de piernas
inquietas, manía,
insomnio y la
discinesia tardía.
Basit H, Kahwaji CI. Clonazepam. [Updated 2023 May 13]. In:
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;
2023 Jan-. Available from:
 PRESENTACIONES: clobazam (10-40 mg)
Biodisponibilid Metabolito Vida media Metabolismo Excreción Clase
ad y pico activo embarazo
plasmático
87% / 0.5-4 horas N- 36-42 horas CYP2C19, unión a Renal 82%, 11% C
desmetilclobaza (larga) proteínas 89-90% fecal
m (N-CLB) N-CLB 71-82
Indicaciones: Ansiedad, crisis horas Agonista parcial de GABA-A
mioclónicas, tónico clónicas y Baja afinidad a BZ-1 (alpha1-
adyuvante del sd. De Lennox- beta2g2) > afín a alpha2-
Gastaut en > 2 años (FDA). beta3g2)
Otras: adyuvante en epilepsia
focal refractaria, status
epilepticus refractario, sd. De
Dravet, ansiedad y epilepsia
catamenial
Humayun MJ, Samanta D, Carson RP. Clobazam. [Updated 2022
Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls
Publishing; 2023 Jan-. Available from:
 PRESENTACIONES: diazepam (2-10 MG)
Biodisponibilida Inicio de Vida media Metabolismo Excreción
d acción

90% 1-5 minutos IV, 24-48 horas CYP3A4, unión Renal

15-60 min VO (metabolito > 200 a proteinas 99%
h). Aumenta con la
edad
Indicaciones:
abstinencia a alcohol,
ansiedad,
espasticidad, status
epiléptico (crisis
febriles en niños)

Dhaliwal JS, Rosani A, Saadabadi A. Diazepam. [Updated 2022 Sep 3]. In: StatPearls [Internet]. Treasure
Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
Tan KR, Rudolph U, Lüscher C. Hooked on
benzodiazepines: GABAA receptor subtypes
and addiction. Trends Neurosci. 2011
Apr;34(4):188-97. doi:
10.1016/j.tins.2011.01.004. Epub 2011 Feb 25.
PMID: 21353710; PMCID: PMC4020178
Epileptic Disord 2016; 18 (3):
217-27
 contraindicaciones

Uso concomitante EPOC, Glaucoma de otras

con otros sedantes FALLA ángulo cerrado Miastenia
Opioides, Depresor CR, Por efecto gravis,
barbitúricos
VENTILAT
miorrelajante VA miorrelajante hipotensión,
ORIA
superiores hipersensibilidad

Vademecum
Bounds CG, Nelson VL. Benzodiazepines. [Updated 2023 Jan 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470159/
 Bounds CG, Nelson VL. Benzodiazepines.
[Updated 2023 Jan 7]. In: StatPearls
[Internet]. Treasure Island (FL): StatPearls
Publishing; 2023 Jan-. Available from:

INTERACCIONES MEDICAMENTOSAS https://www.ncbi.nlm.nih.gov/books/NBK4

70159/

Inhibidores
sEDANTES Inductores ugt
cyp3a4
Carbamazepina, Itraconazol,
fenobarbital, fenitoína ketoconazol, jugo de
y rifampizina toronja, claritromicina,
ritonavir.
 “El uso conjunto con
dibenzodiacepinas tricícilicas (pinas:
clozapina, quetiapina y olanzapina)
aumenta el riesgo de sedación.”
—interacciones
 EFECTOS
02 ADVERSOS
A corto plazo, largo plazo, demencia
 EFECTOS
ADVERSOS
sedación
Enlentencimiento,
visión borrosa,
dificultad para hablar El uso de bzd
Caídas, durante más de 4
semanas, aumenta
fracturas el riesgo de
Pérdida del balance dependencia (30-
Cv Y 40%)
RESPIRATORI
Bradicardia,
AS
bradipnea

Dubovsky SL, Marshall D. Benzodiazepines Remain Important Therapeutic Options in Psychiatric Practice.
Psychother Psychosom. 2022;91(5):307-334. doi: 10.1159/000524400. Epub 2022 May 3. PMID: 35504267.
 Definición de dependencia
Según CIE-10
- Un fuerte deseo o compulsión de
tomar la droga.
- Dificultades para controlar el uso
de drogas, síntomas de abstinencia,
evidencia de tolerancia, descuido
de placeres o intereses alternativos
- Uso persistente de drogas a pesar
de las consecuencias dañinas.
(DSM-IV): la dependencia está
presente por al menos 12 meses
Tan KR, Rudolph U, Lüscher C. Hooked on benzodiazepines: GABAA receptor subtypes and addiction.
Trends Neurosci. 2011 Apr;34(4):188-97. doi: 10.1016/j.tins.2011.01.004. Epub 2011 Feb 25. PMID:
21353710; PMCID: PMC4020178
 Reacciones
paradójicas a las
benzodiacepinas
Extremos de edad, antecedentes de
agresividad. Alcohol, trastornos
afectivos y la demencia. Dosis más
altas de BZD, uso parenteral, fármacos
con t ½ corta y uso de anticolinérgicos.
¿Fisostigmina, flumazenil,
haloperidol?

Mancuso, C. E., Tanzi, M. G., & Gabay, M. (2004). Paradoxical Reactions to Benzodiazepines: Literature Review and Treatment Options. Pharmacotherapy, 24(9), 1177–1185.
Reddy, M. S. S., Achary, U., Harbishettar, V., Sivakumar, P. T., & Varghese, M. (2018). Paradoxical reaction to benzodiazepines in elderly – Case series. Asian Journal of
Dubovsky SL, Marshall D. Benzodiazepines Remain Important Therapeutic
Options in Psychiatric Practice. Psychother Psychosom. 2022;91(5):307-
334. doi: 10.1159/000524400. Epub 2022 May 3. PMID: 35504267.
Intoxicaci
ón
ABC - Flumazenil (NAM): dosis cada
30 seg 0.2 mg - 0.3 mg - 0.5 mg -
repetir cada minuto hasta dosis máxima
3-5 mg. Duración: 19-50 min.
Sharbaf Shoar N, Bistas KG, Saadabadi A. Flumazenil. [Updated 2023
May 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls
Publishing; 2023 Jan-. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK470180/
 Benzodiacepinas y demencia

Ettcheto, M., Olloquequi, J., Sanchez-Lopez, E., Busquets, O., Cano, A., Manzine, P. R., ... & Camins, A. (2020). Benzodiazepines and related drugs as a risk factor in Alzheimer's disease dementia.
Frontiers in aging neuroscience, 11, 344.
Cohorte retrospectiva 2002
al 2015 de 268,170 adultos
> de 50 años
> 30 DDD de
benzodiacepinas, con un lag
libre de 5 años

Hubo un mayor riesgo de EA entre los sujetos

expuestos a bzd o zolpidem (HR: 1,75; IC 95 %: 1,67–
1,82) y entre los expuestos a AD y AP a dosis bajas
(HR: 1.63; 95% CI: 1.42–1.87).

Citation: Lee J, Jung SJ, Choi J-w, Shin A, Lee YJ (2018) Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study. PLoS ONE 13(9): e0204413.
DHe, Q., Chen, X., Wu, T., Li, L., & Fei, X. (2019). Risk of dementia in long-term benzodiazepine users:
evidence from a meta-analysis of observational studies. Journal of Clinical Neurology (Seoul, Korea), 15(1), 9-
19.
 Cómo descontinuar las benzodiacepinas
Anamnesis
01 completa
Valorar si es beneficioso
retirarlas. Tratar
comorbilidad.
02 titular a la baja
10-20% c/2 ss (4-8 ss). En el
hospital si dosis > 100 mg Apoyo no
diazepam
Vigilar 04 farmacológico
03 abstinencia
Mejora resultados (n = 189;
RR = 3.26; 95% CI = 2.36,
Mantener metadona/bupre*
4.51)
Soni, A., Thiyagarajan, A., & Reeve, J. (2023). Feasibility and effectiveness of deprescribing benzodiazepines and Z ‐drugs: systematic review
and meta‐analysis. Addiction, 118(1), 7-16.
Scrandis, D. A., & Duarte, A. C. (2019). Deprescribing benzodiazepines. The Nurse Practitioner, 44(2), 12-14.
Guina, J., & Merrill, B. (2018). Benzodiazepines II: waking up on sedatives: providing optimal care when inheriting benzodiazepine
prescriptions in transfer patients. Journal of clinical medicine, 7(2), 20.
Cloos, J. M., Lim Cow, C. Y. S., & Bocquet, V. (2021). Benzodiazepine high-doses: The need for an accurate
definition. International journal of methods in psychiatric research, 30(4), e1888.
https://doi.org/10.1002/mpr.1888
 Físicos, sensoriales y
psicológicos

Soyka, M. (2017). Treatment of benzodiazepine dependence. New England Journal of Medicine, 376(12), 1147-1157.
MANEJO DE LOS SÍNTOMAS DE
ABSTINENCIA

Discontinuación Abstinencia y craving: Reducción de

Ácido valproico Pregabalina recaídas:
TCA Paroxetina Ácido valproico
TCA
Carbamazepina
gracias a todos
 TABLE OF CONTENTS
01 02 03
FIRST SECOND THIRD
SECTION section section
You can describe the You can describe the You can describe the
topic of the section topic of the section topic of the section
here here here
04 05 06
Fourth section Fifth section Sixth section
You can describe the You can describe the You can describe the
topic of the section topic of the section topic of the section
here here here
“This is a quote, words full of wisdom
that someone important said and can
make the reader get inspired.”

—SOMEONE
FAMOUS
“This is a quote, words full of wisdom
that someone important said and can
make the reader get inspired.”
—SOMEONE
FAMOUS
 EFECTOS ADVERSOS
VENUS SATURN
Venus has a beautiful Saturn is the only
name, but it’s hot planet with rings
MERCUR
MARS
Y
Mercury is the Despite being red,
closest planet to the Mars is a cold place
Sun
JUPITER NEPTUNE
It’s the biggest planet Neptune is the
in the Solar System farthest planet from
the Sun
 WHO
A!
This can be the part of the presentation where
you can introduce yourself, write your email...
INTRODUCTI
ON
Mercury is the closest planet to the Sun
and the smallest one in the Solar System
—it’s only a bit larger than the Moon. It
was named after a Roman god
 INTRODU
CTION
Mercury is the closest planet to the Sun and the
smallest one in the Solar System—it’s only a bit
larger than the Moon. It was named after a
Roman god
THE SLIDE TITLE GOES HERE!

Do you know what helps you make your point clear?

Lists like this one:

● They’re simple
● You can organize your ideas clearly
● You’ll never forget to buy milk!

And the most important thing: the audience won’t miss

the point of your presentation
 01
TITLE OF
THE
SECTION
You can enter a subtitle here
if you need it
 DELIRIUM
01 You can enter a subtitle here if you need it
 01
TITLE OF
THE
SECTION
You can enter a subtitle here
if you need it
MAYBE YOU NEED TO DIVIDE THE
CONTENT

MERCURY VENUS
Mercury is the closest Venus has a beautiful name
planet to the Sun and the and is the second planet
smallest one in the Solar from the Sun. It’s terribly
System hot
 MAYBE YOU NEED TO DIVIDE THE
CONTENT

Mercury Venus
Mercury is the closest Venus has a beautiful
planet to the Sun and the name and is the second
smallest one in the Solar planet from the Sun. It’s
System terribly hot
 YOU can USE THREE COLUMNS, WHY
NOT?

MARS JUPITER SATURN

Despite being red, It’s a gas giant and the It’s a gas giant
Mars is actually a cold biggest planet in the composed mostly of
place. It’s full of iron Solar System hydrogen and helium
oxide dust
HERE YOU HAVE THREE IDEAS
JUPITER
It’s a gas giant and the biggest
planet in the Solar System

MARS
Despite being red, Mars is actually
a cold place. It’s full of iron oxide
dust
SATURN
It’s a gas giant composed mostly of
hydrogen and helium
A PICTURE ALWAYS
REINFORCES THE
CONCEPT
Images reveal large amounts of
data, so remember: use an image
instead of a long text
A PICTURE IS
WORTH A
THOUSAND
WORDS
A PICTURE IS
WORTH A
THOUSAND WORDS
A PICTURE IS WORTH A
THOUSAND WORDS
AWESOME
WORDS
Key words are great for catching your
audience’s attention
AWES
OME
WORD
 DO YOU NEED A GRAPH?

Venus is the second

planet from the Sun

Mercury is the closest

planet to the Sun

Saturn is a gas giant

and has rings
Follow the link in the graph to modify its data and
then paste the new one here.
For more info, click here
 DO YOU NEED A GRAPH?
20 JUPIT It’s a gas giant and
% ER the biggest planet

80 Despite being red,

MARS
% Mars is actually cold

40 SATU It’s a gas giant

% RN composed of
hydrogen
30 mercur Mercury is the
% y closest planet to the
Follow the link in the graph to modify its data and then paste thesun
new one here.
For more info, click here
 YOU CAN USE A TABLE

SURFACE
MASS DIAMETER
GRAVITY
(earths) (earths)
(earths)

MERCURY 0.06 0.38 0.38

MARS 0.11 0.53 0.38

 Maybe you can use a calendar
JUPITER M T W T F S S
It’s a gas giant and the
biggest planet 1 2 3 4 5 6 7

MARS 8 9 10 11 12 13 14
Despite being red, Mars
is actually a cold place 15 16 17 18 19 20 21

SATURN 22 23 24 25 26 27 28
It’s a gas giant composed
mostly of hydrogen 29 30 31
 THIS IS A MAP

MARS
Despite being red, Mars
is a cold place

MERCURY
Mercury is the closest
planet to the Sun
THIS IS A MAP
JUPITER
It’s a gas giant and
the biggest planet

MARS
Despite being red,
Mars is a cold place

SATURN
It’s a gas giant
made of hydrogen
 A TIMELINE ALWAYS WORKS WELL

DAY 1 DAY 2 DAY 3 DAY 4

Mercury is the Jupiter is the Despite being Venus has a
closest planet to biggest planet of red, Mars is beautiful name,
the Sun them all actually a cold but it’s very hot
place
4,498,300,000
Big numbers catch your audience’s attention
3,000,0
00
Big numbers catch your audience’s
attention
 24h 37m 23s
is Jupiter’s rotation period

386,000 km
is the distance between Earth and the Moon
 12,000
Mars is very cold
4,000
Jupiter is a big planet

3,000
Mercury is the first planet
500
Venus is extremely hot
 OUR TEAM

JENNA DOE HELENA JAMES

You can speak a bit about You can speak a bit about
this person here this person here
 OUR TEAM

Jenna DOE TIMMY JIMMY SUSAN BONES

You can speak a bit You can speak a bit You can speak a bit
about this person here about this person here about this person here
 HERE YOU HAVE FOUR IDEAS

MERCURY VENUS
Mercury is the closest Venus has a beautiful
planet to the Sun name, but it’s terribly hot

MARS JUPITER
Despite being red, Mars It’s the biggest planet in
is a cold place the Solar System
YOU can USE FOUR COLUMNS, WHY NOT?

MARS JUPITER MERCURY VENUS

Despite being red, It’s the biggest Mercury is the Venus has a
Mars is a very planet in the closest planet to beautiful name,
cold place full of whole Solar the Sun but it’s hot
oxide System
 02
TITLE OF
THE
SECTION
You can enter a subtitle here
if you need it
TITLE OF THE
SECTION
You can enter a subtitle here if you need it 02
 PROGRESS

80% 20%
Despite being red, Mercury is the closest
Mars is actually a cold planet to the Sun
place
Follow the link in the graph to modify its data and then
paste the new one here. For more info, click here
 PROGRESS
SATUR JUPITE
N R
Saturn is the only Jupiter is the biggest
planet with rings planet in the System

MERCU
MARS
RY
Mercury is the closest Despite being red,
planet to the Sun Mars is a cold place
Follow the link in the graph to modify its data and then
paste the new one here. For more info, click here
 INFOGRAPHICS MAKE YOUR IDEA
UNDERSTANDABLE
SATURN NEPTUNE
Saturn is the only Neptune is the farthest
planet with rings planet from the Sun
1 2 3

MARS JUPITER
Despite being red, It’s the biggest planet
Mars is a cold place of them all
 MAYBE YOU NEED A diagram
MOUNTAINS

mars mercury venus

Despite Mercury is Mercury is Venus has

Mars is Venus is a
being red, a very a planet a
full of iron extremely
Mars is small made of beautiful
oxide dust hot planet
cold planet rock name
 WHAT ABOUT THESE PERCENTAGES?

20% 50% 75%

MARS SATURN MERCURY

Despite being red, Saturn is a gas giant It’s the smallest planet
Mars is a cold place and the planet with of them all
rings
 PERCENTAGES

40% 60%
Despite being red, Mars is Mercury is the smallest
a cold place planet of them all
 03
TITLE OF
THE
SECTION
You can enter a subtitle here
if you need it
03
TITLE OF THE
SECTION
You can enter a subtitle here if you need it
SOMETIMES, REVIEWING CONCEPTS IS A
GOOD IDEA

MERCURY VENUS MARS

Mercury is the closest Venus has a beautiful Despite being red,
planet to the Sun name, but it’s terribly Mars is a cold place
hot

JUPITER SATURN NEPTUNE

It’s the biggest planet Saturn is the ringed one Neptune is the farthest
in the Solar System and a gas giant planet from the Sun
SOMETIMES, REVIEWING CONCEPTS IS A
GOOD IDEA

MERCURY VENUS MARS

Mercury is the closest Venus has a beautiful Despite being red,
planet to the Sun name, but it’s terribly Mars is a cold place
hot

JUPITER NEPTUNE
It’s the biggest planet Neptune is the farthest
in the Solar System planet from the Sun
DESKTOP SOFTWARE

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the screen with your own
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MOBILE WEB

You can replace the image on

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select “Replace image”
 MOCKUP

You can replace the image on the screen with your own work. Just
delete this one, add yours and center it properly
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Desktop software Tablet app Mobile web

You can replace the image You can replace the image
on the screen with your on the screen with your
own work. Just right-click own work. Just right-click
on it and select “Replace on it and select “Replace
image” image”
You can replace the image
on the screen with your
own work. Just right-click
on it and select “Replace
image”
 THANKS
Do you have any questions?
addyouremail@freepik.com
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yourcompany.com

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PHOTOS VECTORS
● Bright pop landscape design ● Hand drawn explorer with backpa
● Beautiful landscape with mountains ck background
● Beautiful natural landscape of mountain
● Woman exploring forest
● Man exploring forest
● Portrait of senior woman out for an advent
ure
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 Fonts & colors used
This presentation has been made using the following fonts:

Darker Grotesque
(https://fonts.google.com/specimen/Darker+Grotesque)

Bebas Neue Bold

(https://fonts.google.com/specimen/Bebas+Neue)

#2a072f #301e4b #42234e #ac5169 #af7172 #fecec5 #feb5ba #fe9ea2

 Storyset
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Pana Amico Bro Rafiki Cuate

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 JANUARY FEBRUARY MARCH APRIL MAY JUNE

PHASE 1

Task 1

Task 2

PHASE 2

Task 1

Task 2

JANUARY FEBRUARY MARCH APRIL

PHASE
1

Task 1

Task 2