EUDRAGIT E 100

Descripción

Eudragit E- 100 es un copolímero catiónico a base de 2-dimetilaminoetilmetacrilato, metilmetacrilato y n-

butilmetacrilato que se presenta en forma de gránulos incoloros a amarillentos, cuyo peso molecular promedio
es 135.000. Se aplica en forma de solución orgánica disuelto en isopropanol y sus películas de protección o
aislamiento son muy efectivos contra la humedad y el oxígeno y son ampliamente recomendados para
enmascarar sabores y olores desagradables. Se disuelven en el estómago a pH ácido debido a la formación
de sales y se hinchan por encima de pH=5 aumentando la permeabilidad al agua. Debido a su elasticidad, no
requiere del agregado de plastificantes.

Formulation

EUDRAGIT® E 100
Organic Protective Coating
The following formulation is calculated for a standard quantity of 1 kg spray suspension. The quantity for film
coating of your substrate depends on
the application and surface area of the substrate. Please contact us if you need assistance to calculate your
individual formulation.

Quantity based on Quantity to be

Function Ingredient Dry substance [g]
dry polymer [%] weighed [g]

Polymer EUDRAGIT® E 100 - 58.8 58.8

Plasticizer Triethyl citrate 20.0 11.8 11.8

Anti tacking Talc 50.0 29.4 29.4

Diluent Acetone - 342.9 -

Diluent Isopropanol - 514.2 -

Diluent Water - 42.9 -

Total 1000.0 100.0

EUDRAGIT® Solution
Add the EUDRAGIT® powder slowly into 50% of the diluent mixture and stir until the polymer is completely
dissolved (approx 30-60 minutes).

Spray Suspension
Add talc and triethyl citrate in the remaining diluent mixture and stir for 10 minutes with a high shear mixer (e.g.
Ultra Turrax).
Pour the excipient suspension slowly into the EUDRAGIT® solution while stirring with a conventional stirrer.
Pass the spray suspension through a 0.5 mm sieve.

For more information about Eudragit, go to: http://eudragit.evonik.com/product/eudragit/en/products-

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