Bases de Datos de Articulos Cientificos

No. No.
2 REVISTA
1 1 Eclética Química
Revista Mexicana de Ciencias

2 2
Farmacéuticas

3 3
Farmacéuticas

4 4
Farmacéuticas
Journal of the Mexican Chemical

5 5
Society

6 6 Farmacéuticas
7 7 Polímeros: Ciência e Tecnologia
9 9 Journal of the Mexican Chemical

Society

10 10
Society

Society
12 12 Vitae
13 13 VITAE

14 14
Farmacéuticas
Revista de la Sociedad Química del

15 15
Perú
16 16 Revista CENIC. Ciencias Químicas

18 18
Farmacéuticas
19 19 Vitae

20 20
Farmacéuticas
22 22 Revista Boliviana de Química
23 23 Polímeros: Ciência e Tecnologia

24 24 Society
25 25 Revista Mexicana de Ciencias

Farmacéuticas

26 26
Farmacéuticas
27 27 Revista Cubana de Química

28 28
Farmacéuticas
29 29 Revista Cubana de Química
31 31 Vitae
32 32 Revista Colombiana de Química

35 35
Farmacéuticas

36 36
Farmacéuticas
37 37 Avances en Química

38 38 Farmacéuticas
39 39 Vitae

Society

42 42
Society
43 43 Revista Mexicana de Ciencias

Farmacéuticas
TITULO
A novel indicator reaction for the catalytic determination of V(V) at ppb levels by the kinetic
spectrophotometric method
Almidón retrogradado para uso en compresión directa. I. Caracterización y pregelatinización

del
almidón de chayote
Almidón retrogradado para uso en compresión directa.

II. Compactación de almidón de chayote retrogradado
Análisis isobolográfico de la combinación

analgésica ketorolaco sistémico y tramadol local en
el modelo de la formalina en ratones
Antibacterial Activity of Pipemidic Acid ions-MgFeAl Layered Double

Hydroxide Hybrid Against E. coli and S. typhi
Anti-inflammatory activity of aqueous and methanolic extracts of Oenothera rosea L' Hér. ex
Ait in the
rat
Aplicações Farmacêuticas de Polímeros
Argentimetric assay of ranitidine in bulk drug and in dosage forms
Biosíntesis de los alcaloides indólicos. Una revisión crítica
Caracterización física de hidroxipropilmetilcelulosa con potencial aplicación oftalmológica: pH,

tensión
superficial, característica de la película
Caracterización reológica de hidroxipropilmetilcelulosa con potencial aplicación oftalmológica
CHEMICAL COMPOSITION AND ANTI-IRRITANT CAPACITY OF WHOLE BODY EXTRACTS OF

Ulomoides dermestoides (COLEOPTERA, TENEBRIONIDAE)
COLOMBIAN BIODIVERSITY, AN OPPORTUNITY FOR

THE STRENGTHENING OF THE PHARMACEUTICAL AND
COSMETIC INDUSTRIES
Compactabilidad como un parámetro de funcionalidad del excipiente GalenIQ 720
COMPARACIÓN DE LA ACCIÓN ANTIINFLAMATORIA Y ANALGÉSICA DEL POLVO

DE Salpichroa origanifolia CON AINES UTILIZADOS EN MEDICINA VETERINARIA
Conductimetric study of the interpolyelectrolyte reaction between chitosan and pectin
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE

DETERMINATION OF DPP-4 INHIBITOR, SITAGLIPTIN, IN ITS PHARMACEUTICAL
PREPARATIONS
Ecofarmacovigilancia en México: perspectivas para su implementación
EFECTO DE ALGUNOS SOLVENTES ORGÁNICOS EN SATURACIÓN SOBRE LAS FUNCIONES

TERMODINÁMICAS DE DISOLUCIÓN DEL NAPROXÉN EN MEDIOS ACUOSOS A pH FISIOLÓGICO
Efecto del bicarbonato de sodio sobre la flotación y la liberación controlada de metronidazol

desde matrices de Methocel K4M y Carbopol 971P NF
Efeito da complexação de metais aos antiinflamatórios na ação contra agentes oxidativos e

radicais livres: ação do cetoprofeno
EFFECT IN ACUTE INFLAMMATION OF SAPOGENIN EXTRACT ANDISOLATED SAPOGENINS

FROM QUINOA WASTE (CHENOPODIUM QUINOA WILLD)
Effect of Crosslinking Agents on Chitosan Microspheres in Controlled Release of Diclofenac

Sodium
Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric
acid matrix tablets
El aceite de pescado protege contra el daño gástrico generado por la administración de

indometacina y adiciona su actividad anti-inflamatoria a la indometacina en la rata
El uso de las microondas en la industria farmacéutica
ESTUDIO DE LA CORROSIÓN DE LA TORRE DE DESTILACIÓN ATMOSFÉRICA DE LA REFINERÍA

“HERMANOS DÍAZ” DE SANTIAGO DE CUBA
Estudios preliminares sobre el efecto analgésico del extracto de hojas de Ageratina glabrata en
dos modelos térmicos de dolor agudo
EVALUACIÓN DE LA ESTABILIDAD DE UNA EMULSIÓN OLEOSA DE CÉLULAS INACTIVAS DE

MYCOPLASMA GALLISEPTICUM
Evaluación tecnológica del polvo de la planta Parthenium hysterophorus L. con un propósito

farmacéutico
EVALUATION OF PHARMACOTHERAPY USED ON GERIATRIC POPULATION IN AN INSTITUTION

OF SPECIAL REGIME WITH THE SCREENING TOOL OF OLDER PERSONS’ POTENTIALLY
INAPPROPRIATE PRESCRIPTIONS (STOPP) CRITERIA
Extended Hildebrand solubility approach applied to some structurally related sulfonamides in
ethanol + water mixtures
Flow injection analysis of vancomycin
Identificación y caracterización in silico de la zona de interación entre el péptido beta-amiloide

y compuestos derivados del naftaleno
Impacto del recubrimiento estético sobre la liberación de tabletas osmóticas

bicompartimentales de Nifedipino
Influence of different types of lactose on tablets compactibility
Las furan-2[5H]-onas (Da,B-butenolidas), su preparación e importancia biológica
Los excipientes y su funcionalidad en productos farmacéuticos sólidos
PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME

POLYELECTROLYTEDICLOFENAC COMPLEXES
Síntesis de nuevos derivados del naftaleno
Synthesis of potential anti-inflammatory compounds, selective inhibitors of cyclooxygenase-2

(COX-2)
Theoretical Study of Isoindolines to Identify them as Cyclooxygenase-1 and -2 Inhibitors by

Docking Simulations
Tratamientos farmacológicos contra alternativos en el manejo de pacientes con artritis

reumatoide
AUTOR PRINCIPAL*
Ramazan Gürkan
María de Lourdes Garzón S.
María de Lourdes Garzón Serra
José Pérez Urizar
Jorge Luis Flores-Moreno
Estela Meléndez-Camargoa
Rodrigo L. Oréfice
K. Basavaiah
Víctor M. Loyola-Vargas
Isabel Andueza
Isabel Andueza
Dary L. MENDOZA M
KARENT BRAVO
Leopoldo Villafuerte Robles
Mónica Alejandra Boeris

Waldo Argüelles-Monal
Lucila Isabel Castro Pastrana
José Carlos Rebuglio Vellosa
Giovanna R . Almanza
Mauro C. M. Laranjeira
Leopoldo Villafuerte-Robles
Aracely Evangelina Chávez Piña
Efrén Hernández Baltazar
Elaine Ojeda Armaignac
Thomas R. F. Scior
T., Pérez Bueno
Yanelis Saucedo-Hernández
José Julián LÓPEZ G

M. Tubino
Alberto Bencomo-Martínez
L.M. Melgoza Contreras
Juan Manuel Urbina-González
Villafuerte Robles, Leopoldo
Yolima BAENA A
Suchitil Rivera-Marrero
Angel Guzmán
Teresa Mancilla
José Luis Montiel Hernández

AUTOR (ES)
Halil İbrahim Ulusoy & Ramazan Gürkan
Mario Isiordia E.1, Amaury Pozos Guillén2, Patricia Aguirre B.3, José Pérez U.3
Alejandra Santana-Cruz,1 Jorge Luis Flores-Moreno,*,1 Roberto Guerra-González2

and María de Jesús Martínez-Ortiz3
Yazmín K. Márquez-Floresa, Hortensia Montellano-Rosalesb, Ma. Elena Campos Aldretec

, Ma. Estela Meléndez-Camargoa
Janaina C. O. Villanova, Rodrigo L. Oréfice; Armando S. Cunha
K. Basavaiah* , B.C. Somashekar
Loyola Vargas, Víctor M.; Sánchez Iturbe, Patricia; Canto Canché, Blondy; Gutiérrez
Pacheco, Luis C.;
Galaz Ávalos, Rosa M.; Moreno Valenzuela, Oscar
Isabel Andueza,* Gisela Ávila y Doris Attias
Dary L. MENDOZA M.1*

, Stephanie SAAVEDRA A.2
KARENT BRAVO ;JAIME ANDRÉS PEREAÑEZ
Samayoa-Sandoval, Liliana; Villafuerte-Robles, Leopoldo
Boeris, Mónica Alejandra; Toso, Ricardo Enrique

Bernabé-Galloway, Patricia; Argüelles-Monal, Waldo; Peniche-Covas, Carlos
Sekaran, C. Bala; Rani, A. Prameela
Castro-Pastrana, Lucila I.; Baños-Medina, María I.; López-Luna, María Argelia;

TorresGarcía, Blanca L
MORA G., Carolina P.; BARBOSA B., Helber J.; MARTÍNEZ R., Fleming
Cedillo-Ramírez, Erika; Hernández-León, Alejandra; Villafuerte-Robles, Leopoldo
Manente, Francine Alessandra; de Almeida Mello, Lucas Rosolen; Arafat Kdudsi Khalil,
Omar; de Carvalho, Cláudio Teodoro; Bannach, Gilbert; Rebuglio Vellosa, José Carlos
Lozano, Maribel; Gonzales, Eduardo; Flores, Yonny; Almanza, Giovanna R.
Gonçalves, Vanessa L.; Laranjeira, Mauro C. M.; Fávere, Valfredo T.; Pedrosa, Rozângela
C
Espinoza Ramos, Rogelio; Villafuerte Robles, Leopoldo
Chávez-Piña, Aracely Evangelina; González-García, Martha Patricia; Jiménez-Andrade,

Juan Miguel
Correa Cuevas, Laura Paloma; Hernández Baltazar, Efrén
Ojeda Armaignac, Elaine; Hing Cortón, Romelia
García P, Guadalupe; Río T., Rosa Elva del; Guzmán M., Ramón; Martínez G., María Isabel;
Scior, Thomas R. F
Pérez Bueno, T.; Sánchez Miranda, L.; Rosado Ruiz-Apodaca, I.; Correa Rivero, H.; Lazo,
R.; Pérez, A.; Riverón, Y.; González, D.; Martínez, S.
Saucedo-Hernández, Yanelis; González-Bedia, Mirtha Mayra; Bravo-Sánchez, Luis

Ramón; GonzálezSan Miguel, Hilda M.; Paul-Remon, Jean; Antunes, Andre; Huyghebaert,
Nathalie; Gonnissen, Yves; Jorge-Rodríguez, María Elisa; Alba-de Armas, Miguel Ángel
Herrera E., Ana María; López G., José Julián

Delgado, Daniel R.; Peña, María Á.; Martínez, Fleming
D. C. Vila, M. M.; Salomão, A. A.; Tubino, M
Bencomo-Martínez, Alberto; Sablón-Carrazana, Marquiza; Rivera-Marrero, Suchitil;

Rodríguez-Tanty, Chryslaine; Álvarez-Ginarte, Yoanna María; Pupo-Meriño, Amaury
Zúñiga-Hidalgo, Tania; León-Rosario, Gabriela; Hernández-Baltazar, Efrén; Melgoza-

Contreras, Luz María
Velázquez González, Karen Alejandra; Ramírez Flores, Eduardo; Villafuerte Robles,

Leopoldo
León-Rojas, Andrés Felipe; Urbina-González, Juan Manuel
BAENA A., Yolima; MANZO, Rubén H.; PONCE D'LEÓN Q., Luisa F.
Rivera-Marrero, Suchitil; Sablón-Carrazana, Marquiza; López-Barroso, Rosa María; Pérez-

Perera, Rafaela; Perera-Pintado, Alejandro; Prats-Capote, Anaís; Garrido-Arteaga, Raine;
Sánchez-Puente, Aniel; Rodríguez-Tanty, Chryslaine
Guzmán, Angel; Díaz, Eduardo; Trejo, Blanca E.; López Muñoz, Francisco J.
Mancilla, Teresa; Correa-Basurto, José; Alavés Carbajal, Karla S.; Sánchez Escalante,
Evelyn T. J.; Trujillo Ferrara, José
Domínguez Hernández, Liliana; Hohlatcheff Ávila, Ana Laura; Montiel Hernández, José
Luis
AÑO DE REVISTA INDEXADA CATEGORIA-
IDIOMA PUBLICACION COLCIENCIAS
INGLÉS 2009
ESPAÑOL 2006
ESPAÑOL 2006
ESPAÑOL 2010
INGLÉS 2016
INGLÉS 2009
PORTUGUÉS 2010
INGLÉS 2007
ESPAÑOL 2004
ESPAÑOL 2000
ESPAÑOL 2000
INGLÉS 2013
INGLÉS 2016
ESPAÑOL 2013
ESPAÑOL 2009
INGLÉS 2012
INGLÉS 2010
ESPAÑOL 2015
ESPAÑOL 2007
ESPAÑOL 2007
PORTUGUÉS 2011
INGLÉS 2013
INGLÉS 2005
INGLÉS 2003
ESPAÑOL 2013
ESPAÑOL 2011
ESPAÑOL 2006
ESPAÑOL 2011
ESPAÑOL 2005
ESPAÑOL 2011
ESPAÑOL 2016
INGLÉS 2016
INGLÉS 2008
ESPAÑOL 2012
ESPAÑOL 2013
INGLÉS 2015
ESPAÑOL 2015
ESPAÑOL 2011
INGLÉS 2011
ESPAÑOL 2011
INGLÉS 2004
INGLÉS 2007
ESPAÑOL 2012
FACTOR DE IMPACTO (F.I) ÍNDICE H*
0.076
0.076
0.076
0.71
0.076
0.123
0.71
0.71
0.71
0.259
0.259
0.076
0.063
NOT FOUND
0.076
0.259
0.076
0.123
0.71
0.076
0.076
0.02
0.076
0.02
NOT FOUND
0.259
0.055
NOT FOUND
0.076
0.076
0.333
0.076
0.259
NOT FOUND
0.71
0.71
0.076
DOI DESCRAGADO
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
iniciales
shidroxipropo
del
bacterianos.
que with hidróxido
otros anti-
interacción
Es
V(IV).
e
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o
más
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xilo
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irritant
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laminar en in Se
de
properties
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method
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se
ratones
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estudio
for este
tiene
the a
que
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ketorolaco
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is
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confirmaron
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evaluar
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se
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estudiaron
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es
matriz
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blood
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hidrocoloide
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farmacêutico
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de
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known
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antiinflamat
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oria
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mercury(II)t
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oria
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used
n, fuethe in el en
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el
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and
n
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medicament procesoen fixed-time
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composition producto la El alcaloide,
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sido
No. REVISTA
1 Università degli studi di Trieste
2 Universidade Federal de Santa Catarina
Journal of
3 Mazandaran University of Medical
Sciences
J.K.K. NATTRAJA COLLEGE OF

4 PHARMACY
KOMARAPALAYAM
5 Atmiya Institute of Pharmacy
6 S.N.D.T. Women’s University, Mumbai
7 Journal of Pharmaceutics & Drug

Development
International Journal of
8 Pharmaceutical Sciences and
Nanotechnology
Journal of Innovations in
9 Pharmaceuticals and Biological
Sciences
INTERNATIONAL JOURNAL OF
10 PHARMACEUTICAL SCIENCES AND
RESEARCH
11 INDO AMERICAN JOURNAL OF

PHARMACEUTICAL SCIENCES
Journal of Thermal Analysis and

12
Calorimetry
13 International Journal of PharmTech

Research
International Journal of Research in

14
Pharmaceutical Sciences
TITULO
Preparazione e caratterizzazione di forme farmaceutiche solide orali a partire da materiale

composito
Avaliação de complexos de sílica mesoporosa (SBA-15) com fármacos (Naproxeno e

Estavudina)
Evaluation of solid-state physical stability and compatibility of piroxicam with tablet excipients
by physicochemical methods
Formulation and Evaluation of Lansoprazole Enteric Coated Pellets.
Formulation and Characterization of Bilayer Tablet of Dicyclomine hydrochloride and

Mefenamic acid for Colon Targeted Drug Delivery
Developmant of oral controlled drug delivery systems for pain management
Croscarmellose Sodium Efficiency in the Development of a Generic Capsule

Formulation of Piroxicam, Comparable Dissolution Profile to the Innovator
Product, Feldene
Preparation and In vivo Evaluation of Mucoadhesive Microspheres for Gastroretentive Delivery

of Misoprostol
Nanocarrier based transdermal formulation of NSAID: Optimization of

drug loading and analysis of permeation characteristics
FORMULATION AND EVALUATION OF NAPROXEN AND PANTOPRAZOLE MULTILAYERED

TABLETS
DESIGN, DEVELOPMENT AND EVALUATION OF NOVEL

ORAL MEDICATED JELLIES
Compatibility study of the acetylsalicylic acid with different solid dosage forms excipients
Formulation Development and Evaluation of Floating Microspheres Of Gemifloxacin Mesylate
Studies on the investigation of ¬preformulation parameters, compatibility studies to design

and formulate the etodolac solid dispersions
AUTOR PRINCIPAL*
NA
NA
Jafar Akbari (Mazandaran University of

Medical Sciences)
NA
NA
NA
Nwoko Valentine E
D.V. R. N. Bhikshapathi
Prachi Pandey
V. Hemalatha
Melissa R Cardoz
Bogdan Tita
Nagasree K
Limce Thampi
AUTOR (ES)
Bellich, Barbara
Pereira, Rafael Nicolay
Reza Enayatifard , Jafar Akbari , Majid Saeedi , Katayoun Morteza-Semnani , Amir-Hasan

Kasiri
Diwakar Manohar, Pachabhai
Chauhan, Shefali S.
Meenal Mukund Rane
Nwoko Valentine E
K. Ranjith Kumar
and D.V. R. N. Bhikshapathi
Prachi Pandey, S. S Pancholi
V. Hemalatha*, N. Mounika, A. Devi Chandini, K. Geethika, M. Indraja, K. Ramya and P.

Srinivasa Babu
Melissa R Cardoz*and Padmini Ravikumar
Dumitru Tita;Tunde Jurca; Adriana Fulias; Eleonora Marian; Bogdan Tita
Nagasree K*, Chowdary GV & Mahendra Kumar CB
Limce Thampi; M Swamivel Manickam; S Kuppuswamy

AÑO DE
IDIOMA PUBLICACION FACTOR DE IMPACTO (F.I) ÍNDICE H*
PORTUGUÉS 2008 NA
PORTUGUÉS 2009 NA
INGLÉS 2014 0.317
INGLÉS 2012 NA
INGLÉS 2013 NA
INGLÉS 2013 NA
INGLÉS 2014 NOT FOUND
INGLÉS 2016 1.106
INGLÉS 2017 0.34
INGLÉS 2017 3.6
INGLÉS 2013 1.953
INGLÉS 2015 2.531
INGLÉS 2016 0.302

DOI DESCRAGADO
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
NA SI
SI
https://doi.org/10.1007/s10973-013-2937-2
NA SI
NA SI
and FT-IR èoptimize
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floating
manner,
be
diethyl- and ofof Coated proporción
after coated
selected
categorized
contra le,
1,3,4,9-
study
further that
o HIV. as 1 de 1: 1 (p: p).
common
preparazion
microsphere
which use
ispH Pellets
hr
tablet.
as
tetrahydropy
(baseline,
incorporated in
dependent
biocompatibl 6.8
Class
A First, II3, preparación
Sobre la
e including
dei
essential
Phosphate
Naproxen
e, s
variables. sistemi
by
nontoxic, for is del
baseproducto
de los
drugs
estavudina,
rano-(3,4,-b)
and
diluents,
hacost in
fatto 6
Tablets
low Ionotropic
anti
buffer.
prepared
according ulcer
From
were andas
to resultaron
resultados
também
months).
indole-1
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seguito
gelation la
therapy.
core
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chamada the
thetablet The satisfactorio
térmicos
acetic
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caratterizzaz
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gel acidde is
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friendly,
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with
was
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fármaco
pyranocarbo
scanningand
fisica,
different
shows
estudios
concluded
method.
weight
available,
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hidrofílico,
calorimeter)
xylic
formulations acid liberación de
confirmados
solubilising
drug
thatnecessaria
drug
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variation.percent
better to
release
it is Capsules; por fármaco
FT-IRiny
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solúvel
and
group em
per agents.
carrier
friability
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were
enteric
drug
patient
água ofFTIR
appurare
drug e
of
ratio.
andIn Croscarmello vitro
is dede
análisis
non-steroidal
prepared
Gemifloxacin
95.23 (fourier
order
lo stato
withinto Misoprostol;
by se sodium; In
poorly percent
coated
content.
tolerated
parcialmente
transform
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rayos X, sey
investigate
solido
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assay 1
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vitro
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una posible
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microsphere
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stabilityF1
develop to InF9
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interacción en
dissolved,
importante
(NSAIDS).Be
determine
screened
particolare
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le Korsmeyer
factors
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study
found
and this
característic
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factors
tecniche
ASA
characterize
showed
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study.
evaluate
is possible
easilythe
and and peppas; química pH
HCl 0,1N y
withincoated
oral
absorbed
developmenaeleven
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their éparticle
seu the
jelly
levels Mucoadhesi entre
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el ASA
d adottate
for
limit.
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formulations better
tablet,Invitro fosfato
con 7,4
through
coeficiente
tand
between
sono of
excipients any the
by of Arthritis,
state: ve
ofretention
dissolution
Pantoprazol size,
Ranitidine
gastro- han
polivinilpirrol
de
dosage drug partição
optimized
calorimetria
differential
scanning form
and microsphere
Transdermal
profiles prepared
e
Hydrochlorid study
(20mg)
intestinal
(Log of all s. demostrado
idona K30
it is
a scanning essential
excipients.
process
scansione
electron
microsphere drug
showed
drug
the
membrane.
P(octanol/ág
to
Results: study
parameters. layer
batches
e. that
the
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(PVP)
calorimetry
differenziale
microscopy,
s
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indicateapplied
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drugto Naproxen, liberación de
ua)):
compatibility
results
(DSC)
(DSC),
FT-IR
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chic
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and
raggi
study, of Permeation, estearato
drug F9
release
oninnovator
(ou
ofduodenal having
drug
transdermal get
studies,
0.14).from
release and Pantoprazol
NSAID fármacos
magnesio,
thermogravi
X thesu
combination
organoleptic polvere
DSC,
better
tablet Pediatrics, sigue
e, Delayed una
respectivam
formula
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excipients,
metry/deriva from
drug
(PXRD), valor
percentage
and
resistance
product.
was , jejunum
includesdirectly
physical The in release,
bitter taste, cinética
ente, unade
lhe the confere
different
permeation
microscopia
yield, divided
tive drug a
regions
0.1
prepared
affected
characteristi
lactose
característic N HCL of
asby Multi-layered
oral orden
posible cero.
properties
formulations
wasthermogravi
elettronica
entrapment, found of
intestine. to
a
after and
tablets
amount
be cs,highest
the
powder 3good
drug
main
hidrofílica were
and etc. tablets
of6 medicated interacción
%The metry
(SEM),
buoyancy,
release
evaluated
polymer. results in
ocontent,
filler
que
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analysis
hotstage along
explica
results
for
stability
pH, jellies, física con
showed
phosphate
From
syneresis,
with for
sua the
corn natural dióxido de
from
storage
transferoso
completed
microscopi
studies
significant the in
and Acetylsalicyli
studies
25° buffer
physicochem release
Ctaste
starch,
solubilidade
mal /60% pH
helps
gel, RH polymers, silicio
(HSM),
profile by
found
6.8.
masking Fourier
higher From
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to
it wasbe
and c acid
ranitidine
to emand sodium
decide
whereas
transform
within
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água.
light 40°the Cof Excipient coloidal y
O
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properties
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objetivo
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drug above
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vitroRHthat
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mucoadhesivinfrared
scattering.
results limits.
such
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as Compatibility
e esteárico
sulphate
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approaches
found showed
spectroscop
Successivam to and
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discussion
weight
sustained
testing
magnesium e allit Gemifloxacin (Ac. St.).
avaliar
for
statistically
slightly
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(FT-IR)
ente the the le a TG/DTG/DSC
and mesylate,
might
variation,
release
stearate.
complexaçã
developmen were
significant
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in
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formulazioni
formulations
sDicyclomine
concluded
conducted.upper
hardness, 32
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FT-IR X-ray
GI HPMC, gum
tF9 of
difference
skin powder
approntate solid
during
were
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full that
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hydrochlorid
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factorial
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diffraction
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selected
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transform andstate floating
design
fármacos
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caratterizzat from was
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andUnder
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infrared study
enteric
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times.
liposomal
e modelos
dispersions
anche
formulation for gel
dal s.
content.revealed
coated
acid
differential
investigate
(naproxeno was The ; DSC;
based for
all
formulation.
compatibility
punto
that delayed
storage
onthe di the
pellets
in-vitro
obseived
the scanning
combine
e Thedrug offor Etodolac;
The release
conditions
study. reason
vista
physic
bioavailabilit
Lansoprazol
the
tablets release
calorimeter
effect
estavudina).
piroxicam
may
DSC
tecnologico
bilayerof 2 Excipients;
were
be
has
chemical
y
e
studieswas tablet
studies
formulation found
were and Solid
e Algumas
done
tablets
fusion
proven
dissolutivo
release byofto
to to
be
conducted
containing
showed variable:
técnicas be
stable that a dispersions.
showed
Phospholipid
inbe, solvent
studies.
increased among
termini an
Indi
Dried in acidic
foram
evaporation
increase
s for
higher
there
duringstarch in
the
medium
Naproxen
amountwasselected
studi
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significantly indiand
noTG, of
usadas:
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cinetica by
di
vitro
shows
core when release
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tablets,
nHPMC.
interaction
Croscarmello
throughDSC,
using
time.
techniques,
solubilizzazio
study
compared
FTIR,The
the
DSC
skin.
of
drug
MEV Naproxen
se kinetics
between release
sodium.
emost
polymers
and Both
the ne
formulation
in
release
drug
FTIR
with eCLAE.
basic
enteric
the
diof
and
like
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A Eudragit
not
Transferoso
sensitive The
partir show
rilascio. dos
andS
F9marketed
medium.showed
coated
optimized
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systematic
resultados
100,mal
specific
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gel
after in
in
tablets.
Therefore
tablets
batch
formulation
obtidos The The
and
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interaction
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alcuni12 h casi
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between and bestideal
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of è
No. REVISTA
UNIVERSIDADE FEDERAL DO RIO

1 GRANDE DO SUL
FACULDADE DE FARMÁCIA
TITULO
Aplicação de métodos termo-analíticos e espectroscópicos na avaliação do

comportamento do fármaco isoniazida frente a adjuvantes
AUTOR PRINCIPAL*
Cristián Jesús Velásquez Armijo

AUTOR (ES)

IDIOMA
PUBLICACION COLCIENCIAS
PORTUGES 2003
FACTOR DE IMPACTO (F.I) ÍNDICE H*
DOI DESCRAGADO
NA SI
não métodos
termo-
encontrado
analíticos,
na literatura.
estudo de
Os compatibilid
adjuvantes
ade
avaliados
RS fármaco/adju
KW
foram: ácido vante,
esteárico,
comportame
amido,
nto térmico,
celulose isoniazida,
microcristali
adjuvantes
na,
tecnológicos
crospovidon
primários,
a,
formas
croscarmelo
se sódica, farmacêutica
s sólidas,
dióxido de
agregação
silício
coloidal por via
úmida,
estearato de
processo de
magnésio,
compactaçã
glicolato de o
amido
sódico,
hipromelose,
lactose,
manitol,
polidona e
talco. Para as
misturas
físicas, a
maioria dos
adjuvantes
mostrou-se
compatível
com o
fármaco em
questão.
Foram
verificadas
interações
com o ácido
esteárico, o
glicolato de
amido
sódico, a
lactose, o
manitol e a
povidona. A
isoniazida
mostrou a
formação de
uma mistura
eutética com
o manitol e
de interação
química com
a lactose. A
agregação
por via
úmida e o
processo de
compactaçã
o não
mostraram
influências
adicionais na
compatibilid
ade das
misturas
avaliadas. Os
resultados
observados
foram
confirmados
por métodos
No. REVISTA
Drug Development and Industrial

1
Pharmacy
2 Drug Development and Industrial

Pharmacy
3 Expert Opinion on Drug Delivery
4 The Physician and Sportsmedicine
Pharmaceutical Development and

5
Technology
6 Pharmaceutical Development and

Technology

7
Pharmacy

8
Technology

9 Pharmacy
TITULO
Compatibility Studies Between Ibuprofen or Ketoprofen

with Cellulose Ether Polymer Mixtures Using Thermal
Analysis
Multiparticulate Drug Delivery System of Aceclofenac:

Development and In Vitro Studies
Nanoparticles in drug delivery: mechanism of action,

formulation and clinical application towards reduction in
drug-associated nephrotoxicity
Dimethyl Sulfoxide: An Effective Penetration Enhancer for Topical Administration of NSAIDs
Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam
Design and in vitro evaluation of novel sustained-release matrix tablets for lornoxicam based
on the combination of hydrophilic matrix formers and basic pH-modifiers
In vitro release of ketoprofen from hydrophilic matrix tablets containing cellulose polymer
mixtures
Preparation and in vitro characterization of piroxicam enteric coated pellets using powder
layering technique
Compatibility Study Between Ketoprofen and Tablet Excipients Using Differential Scanning
Calorimetry
AUTOR PRINCIPAL*
Srinivasa Reddy Meka
Karrie Marren
bd El-Gawad H. Abd El-Gawad
Mona Hassan Aburahma
M. L. Vueba
Jaleh Varshosaz
S. A. Botha
AUTOR (ES) IDIOMA
M. L. Vueba, F. Veiga, J. J. Sousa & Prof. Maria Eugénia Pina Inglés
Gopal Venktesh Shavi, Usha Nayak, Ranjith Kumar Averineni, Karthik Arumugam, Inglés
Srinivasa Reddy Meka , Udupa Nayanabhirama & Pandey Sureshwar
Dustin L Cooper, Christopher M Conder & Sam Harirforoosh Inglés
Karrie Marren Inglés
Amira Motawea, Thanaa Borg, Manal Tarshoby & Abd El-Gawad H. Abd El-Gawad Inglés
Yassin El-Said Hamza & Mona Hassan Aburahma Inglés
M. L. Vueba , L. A. E. Batista de Carvalho, F. Veiga, J. J. Sousa & M. E. Pina Inglés
Jaleh Varshosaz , Naser Tavakoli & Azadeh Serri Inglés
S. A. Botha et al Inglés
PUBLICACION COLCIENCIAS FACTOR DE IMPACTO (F.I) ÍNDICE H*
2005 2.295
2009 2.295
2014 5.657
2011 1.292
2017 1.86
2010 1.86
2013 2.295
2009 1.86
2008 2.295
DOI DESCRAGADO
https://dbvirtual.uniatlantico.edu.co:2667/10.1080/03639040500306153 No
https://dbvirtual.uniatlantico.edu.co:2667/10.1517/17425247.2014.938046 No
https://dbvirtual.uniatlantico.edu.co:2667/10.3810/psm.2011.09.1923 No
 https://dbvirtual.uniatlantico.edu.co:2667/10.1080/10837450.2016.1231810 No
https://dbvirtual.uniatlantico.edu.co:2667/10.3109/03639045.2012.729146 No
http://dbvirtual.uniatlantico.edu.co:2145/doi/abs/10.3109/03639048909040
221
No. Columna1
1 Journal of Pharmaceutical Sciences

Pharmacy
International Journal of Applied

3 Pharmaceutics
Fabad Journal of Pharmaceutical

4
Sciences
International Journal of Drug Delivery

5 Technology
7 Advanced Pharmaceutical Bulletin
Asian Journal of Pharmaceutical and

8 Clinical Research
9 Indian Journal of Pharmaceutical

Sciences

10 Clinical Research
11 Latin American Journal of Pharmacy

12
Pharmaceutics
Developing Solid Oral Dosage Forms:

13 Pharmaceutical Theory and Practice:
Second Edition
14 AAPS PharmSciTech
15 Journal of Young Pharmacists

Journal of Pharmaceutical Sciences
16 and Research
Journal of Pharmaceutical
17
Investigation
Indian Journal of Pharmaceutical

18
Education and Research
Journal of Pharmaceutical
19
Investigation
Acta Poloniae Pharmaceutica - Drug

20
Research
21 Molecular Pharmaceutics
22 Asian Journal of Pharmaceutics
23 International Journal of Research in

24 Der Pharmacia Lettre

Pharmacy
International Journal of Pharmacy and

26

Research

28
Sciences
29 Asian Journal of Pharmaceutics

31
Research
Journal of Drug Delivery Science and
32 Technology

33
34 Indian Drugs
35 International Journal of Pharmaceutics
Journal of Pharmaceutical and

36
Biomedical Analysis

37
Clinical Research

38 Pharmacy

Research
International Journal of PharmTech

40 Research
41 International Journal of Research in

43 Pharma Research

44
45 Journal of Applied Pharmaceutical

Science
International Journal of Drug

46
Development and Research
Revista de Ciencias Farmaceuticas

47
Basica e Aplicada
International Journal of
50 Pharmaceutical Sciences Review and
Research

51

52
Biomedical Analysis
53 Advanced Pharmaceutical Bulletin
Research Journal of Pharmacy and

54 Technology
55 International Journal of Pharmacy and

Technology

56 Pharmaceutical Sciences
57 American Pharmaceutical Review

58
Technology

60

62

63

65
Research

66
Journal of Pharmacy and Bioallied

67
Sciences

68
Research

69
Research

70 Technology
71 Asian Journal of Pharmaceutical and

Clinical Research

72 Pharmaceutical Sciences

75 Saudi Pharmaceutical Journal
Journal of Chemical and

76
77 Journal of Pharmacy Research
78 International Journal of Drug Delivery

79
80 Technology

81
Clinical Research
82 Farmacia
83 Pharmaceutical Research
84 Indian Drugs

85
Technology
86 Farmacia
87 Journal of Applied Pharmaceutical

Science

88 Technology
89 Research Journal of Pharmacy and

Technology
91 Research Journal of Pharmacy and

Technology
92 Acta Pharmaceutica
93 Pharma Research
94 Journal of Global Pharma Technology
95 Chemical and Pharmaceutical Bulletin

96 Clinical Research
97 International Journal of Pharmacology

98
Technology

TITULO
Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired
Gastric Motility
Stability of pharmaceutical salts in solid oral dosage forms
Development, characterization and evaluation of soft oral edible gel using gellan gum
Formulation and evaluation of baclofen mucoadhesive buccal films
Design, development and optimization of pulsatile core in cup tablets of naproxen
The influence of excipients on physical and pharmaceutical properties of oral lyophilisates

containing a pregabalin-acetaminophen combination
Thermal stability and kinetic study of fluvoxamine stability in binary samples with lactose
Effect of effervescence in combination with superdisintegrants in the formulation of

propranolol hcl oral disintegrating tablets
Design and pharmacodynamic evaluation of optimized microporous osmotic tablets of

venlafaxine hydrochloride
Formulation development, characterization, and in vitro evaluation of floating matrix dosage

form of tramadol hydrochloride using various polymers
Compatibility studies of entacapone with carbidopa, L-dopa, and pharmaceutical excipients for
a fixed dose combination product
Preparation, characterization and evaluation of floating microparticles of ciprofloxacin
Excipient compatibility and functionality
QbD-Oriented Development and Characterization of Effervescent Floating-Bioadhesive Tablets

of Cefuroxime Axetil
Development and characterization of thermosensitive intranasal gel containing paliperidone

loaded microspheres
Controlled - Release effervescent floating tablet of verapamil hydrochloride: Development and
opitmization
Quality by design approach for development and optimization of Quetiapine Fumarate

effervescent floating matrix tablets for improved oral bioavailability
Development of extended release matrix tablets of felodipine through solid dispersions for
better drug release profile by a 32factorial design
Brain targeting efficiency of Curcumin loaded mucoadhesive microemulsion through intranasal

route
Identification of pharmaceutical excipient behavior of chickpea (Cicer arietinum) starch in

gliclazide immediate release tablets
Acid-Base Interactions of Polystyrene Sulfonic Acid in Amorphous Solid Dispersions Using a

Combined UV/FTIR/XPS/ssNMR Study
Drug-excipient interaction study for apple cider vinegar with 20 potential excipients using
modern analytical techniques
Selection of excipients for galantamine hbr orodispersible tablet through drug excipient
compatibility study
Design and evaluation of sodium alginate microspheres loaded with Gatifloxacin
Development, optimization and in vivo characterization of domperidone-controlled release

hot-melt-extruded films for buccal delivery
Glimepiride fast disintegrating tablets: Formulation, evaluation and in vivo disintegration and
dynamic studies
Investigation of blends of cashew and xanthan gums as a potential carrier for colonic delivery
of Ibuprofen
Preparation and characterization of PEG-albumin-curcumin nanoparticles intended to treat

breast cancer
Formulation and evaluation of chlorhexidine medicated chewing gums by different methods
In vitro drug analysis and stability studies of optimized formulations of aceclofenac (100 mg)
tablets
Effect of polymer and plasticizer on thin polymeric buccal films of meloxicam designed by
using central composite rotatable design
Combined dosage form of pioglitazone and felodipine as mucoadhesive pellets via hot melt
extrusion for improved buccal delivery with application of quality by design approach
Formulation and evaluation of levamisole oral dispersible tablets
Improvement of dissolution rate of febuxostat using hybrid technique of spherical

crystallization and solid dispersion
Evaluation of microwave oven heating for prediction of drug-excipient compatibilities and

accelerated stability studies
Structure elucidation and quantification of impurities formed between 6-aminocaproic acid

and the excipients citric acid and sorbitol in an oral solution using high-resolution mass
spectrometry and nuclear magnetic resonance spectroscopy
Design and evaluation of torsemide controlled release matrix tablets
The stress stability of olanzapine: Studies of interactions with excipients in solid state
pharmaceutical formulations
Selection of excipients for the formulation of ceftriaxone sodium loaded chitosan nanoparticle
through drug-excipient compatibility testing
Selection of excipients for memantine hydrochloride nanoparticles through drug excipient

compatibility testing
Selection of excipients for the formulation of Ceftriaxone sodium loaded chitosan Nanoparticle
through drug - Excipient compatibility testing
Formulation design and invitro evaluation of oral disintegrating tablets of Carbidopa and
Levodopa
Formulation and optimization of ocular films of ofloxacin and ketorolac tromethamine
Formulation and evaluation of pioglitazone hydrochloride pellets
Formulation, in vitro characterization and stability studies of fast dispersing tablets of

diclofenac sodium
Formulation and in vitro evaluation of sustained release floating matrix tablet of Rosiglitazone
Maleate
Solid-state characterization and pharmaceutical compatibility of ziprasidone hydrochloride

Formulation and optimization of olanzapine sustained release matrix tablets for the treatment
of schizophrenia
Diclofenac sodium pellets for flexible pediatric drug dosing: Preparation, characterization and
evaluation
Preparation and evaluation of sustained release matrix tablets of bosentan by using wet
granulation technique
Selection of excipients for polymer coated capsule of celecoxib through drug-excipient

Drug-excipient compatibility screening-Role of thermoanalytical and spectroscopic techniques
Drug-drug/drug-excipient compatibility studies on curcumin using non-thermal methods
Compatibility studies of quercetin with pharmaceutical excipients used in the development of

novel formulation
Advances in analytical techniques used in predicting drug-excipient interactions
Drug-excipients compatibility studies of Nicorandil in controlled release floating tablet
Investigation of excipient compatibility and associated degradations for the formulation

development of a small molecule pharmaceutical compound
Formulation and evaluation of bilayer tablet of metformin HCl and pioglitazone HCl
Formulation and evaluation of mucoadhesive vaginal tablets of tenofovir disoproxil fumarate
Formulation development and evaluation of fast disintegrating tablets of Ambroxol

hydrochloride for pediatrics- a novel approach for drug delivery
Kinetics of the esterification of active pharmaceutical ingredients containing carboxylic acid

functionality in polyethylene glycol: Formulation implications
Formulation and evaluation of modified pulsincap drug delivery system of rizatriptan benzoate
Application of modified USP apparatus I and in situ fiber optic analysis for drug release from
ibuprofen nanospheres
Preparation and characterization of ethyl cellulose microspheres encapsulating metformin
hydrochloride and glipizide
Formulation, characterisation and evaluation of sustained release microcapsules of

gemifloxacin
In-situ injectable thermosensitive gel based on poloxamer as a new carrier for Tamoxifen
citrate
Design and development of cefdinir niosomes for oral delivery
Application of differential scanning calorimetry in evaluation of solid state interactionsin

tablets containing acetaminophen
Effect of two hydrophobic polymers on the release of gliclazide from their matrix tablets
Formulation and evaluation of Nizatidine floating tablets by using natural, semisynthetic and
synthetic polymers
Formulation and evaluation of bilayermatrix tablet of Pioglitazone HCL Metformin HCL USP
15MG&500MG
Study on crystallinity and compactibility of binary mixture of analgesic substances with

Microcrystalline cellulose
Selection of excipients for nanoparticles formulations of Nateglinide through drug-excipients

compatibility study
Formulation development and evaluation of lamivudine controlled release tablets using cross-
linked sago starch
Paclitaxel loaded carrier based biodegradable polymeric implants: Preparation and in vitro
characterization
Formulation of Venlafaxine Sustained Release capsule dosage form
Formulation design and optimization of novel mouth dissolving tablets for venlafaxine
hydrochloride using sublimation technique
Formulation and evaluation of sitagliptin phosphate and metformin hydrochloride trilayered

tablets
Fabrication and evaluation of Domperidone transdermal films

Formulation and evaluation of Bi-Layered matrix tablets of Metformin and Pioglitazone for
Biphasic Drug Release
Design, development and evaluation of floating tablets of tapentadol hydrochloride using

Chitosan
Design of double layer tablets of valethamate bromide by using various polymers by direct
compression method
Impact of excipient interactions on solid dosage form stability
Compatibility studies of acetazolamide with excipients by using high performance liquid

chromatography (HPLC) technique
Formulation and In-Vitro evaluation of Aceclofenac Controlled release tablets by wet

granulation method and solid dispersion technique
Compatibility studies of indapamide/pharmaceutical excipients used in tablet preformulation
Formulation and evaluation of gastroretentive floating tablets of domperidone maleate
Formulation and optimization of tenoxicam orodispersible tablets by solid deposition

technique
Compatibility study of Aceclofenac and tablet disintegrants by thermal and nonthermal

methods
Compatibility studies of olanzapine pre-formulated with excipients by thermal analysis:

Preliminary study
Compatibility study of gatifloxacin with various excipients
Compatibility studies of nateglinide with excipients in immediate release tablets
Design, development and In vitro evaluation of floating tablets of atenolol
Preparation and evaluation of tramadol hydrochloride microspheres by coacervation phase

separation technique using various solvents and non-solvents
Design of meloxicam and lornoxicam transdermal patches: Preparation, physical

characterization, ex vivo and in vivo studies
A study on the effect of different cellulose polymers on release rate from tramadol loaded
microspheres prepared by emulsion solvent evaporation method
Studies of in vitro evaluation and formulation of aceclofenac loaded PLGA microspheres
Understanding drug-excipient compatibility: Oxidation of compound A in a solid dosage form

Understanding drug-excipient compatibility
Hydroxypropyl Methylcellulose Acetate Succinate: Potential Drug - Excipient Incompatibility
Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: In
Vitro and In Vivo studies
AUTOR PRINCIPAL
AUTOR (ES) IDIOMA
Suzuki, H; Yakushiji, K; Matsunaga, S; Yamauchi, Y; Seto, Y; Sato, H; Onoue, S. Inglés
Nie, H; Byrn, S.R; Zhou, Q; Inglés
Vijayanand, P; Deepa, A; Bhagavan Raju, M Inglés
Ali, M.A.M.; Sabati, A.M; Ali, B.A; Inglés
Patel, R.H; Trivedi, H.J; Patel, K.N; Patel, M.M Inglés
Chiriac, A.P.; Diaconu, A.; Nita, L.E.; Tudorachi, N.; Mititelu-Tartau, L.; Creteanu, A.;
Dragostin, O.; Rusu, D.; Popa, G.; Inglés
Ghaderi, F.; Nemati, M.; Siahi-Shadbad, M.R.; Valizadeh, H.; Monajjemzadeh, F. Inglés
Thulluru, A.; Sai Kumar, V.; Pavan Kumar, M.; Roshitha, B
Monica, R.P.R.; Shilpa, H.J.; Swati, S.T.; Vaishali, S.K.
Anepu, S.; Duppala, L; Soma Sundari, M.
Rodovalho-Mitani, L.F.F.; Serpa, R.C.; Cunha-Filho, M.S.S.; v
Durgapal, S.; Mukhopadhyay, S.; Goswami, L.
Narang, A.S.; Mantri, R.V.; Raghavan, K.S.
Bansal S, Beg S, Garg B, Asthana A, Asthana GS, Singh B Inglés
Maniyar, A.J.; Patel, G.M.; Shelat, P.K Lalwani, A.N

Patidar, D.; Shah, S.K.; Tyagi, C.K.; Pandey, H.
Narendar, D.; Arjun, N.; Someshwar, K.; Madhusudan Rao, Y.
Srikar, G.; Avula, P.; Annapurna, S.; Boola, M.
Mandal, S.D.; Mandal, S.; Patel, J.
Meka, V.S.; Yee, P.; Sheshala, R.
Song, Y.; Zemlyanov, D.; Chen, X.; Nie, H.; Su, Z. Fang, K., Yang, X.; Smith, D.; Byrn, S.
Lubach, J.W.
Biswal, B.; Anurekha, J.
Jeevitha, M.; Pandey, V.P.
Nagasree, K.; Chowdary, G.V.; Mahendra Kumar, C.B.; Reddy, T.R.M.; Bhikshapathi,
D.V.R.N.
Palem, C.R.; Dudhipala, N.R.; Battu, S.K.; Repka, M.A.; Yamsani, M.R.
Jogala, S.; Ankathi, L.; Jarupula, R.N.;
Fosu, M.-A.; Ofori-Kwakye, K.; Kuntworbe, N.; Bonsu, M.A.
Thadakapally, R.; Aafreen, A.; Aukunuru, J.; Habibuddin, M.; Jogala, S.
Rajitha, K.; Rao, Y.M.
Bushra, R.; Shoaib, M.H.; Ali, H.; Zafar, F.; Shafiq, Y.; Aslam, N.
Zaman, M.; Hanif, M.; Qaiser, A.A.

Palem, C.R.; Dudhipala, N.; Battu, S.K.; Goda, S.; Repka, M.A.; Yamsani, M.R.
Praveen, N.; Ramesh, Y.; Gnanaprakash, K.; Gobinath, M.; Mahesh, M., Monica, A.
Tandel, D.B.; Shah, P.A.; Patel, K.G.; Gohel, M.C.; Thakkar, V.T.; Gandhi, T.R.
Schou-Pedersen, A.M.V.; Østergaard, J.; Cornett, C.; Hansen, S.H.
Schou-Pedersen, A.M.V.; Cornett, C.; Nyberg, N.; Østergaard, J.; Hansen, S.H.
Macharla, A.; Velmurugan, S.; Veerabhadra Rao, P.
Djordjević Filijović, N.; Antonijević, M.D.; Pavlović, A.; Vučković, I.; Nikolić, K.; Agbaba, D.
Manimekalai, P.; Manavalan, R.
Joysa Ruby, J.; Pandeyv, V.P.
Manasa, M.; Raj Kumar, B.; Purendar Reddy, A.; Kovid Reddy, A.; Mounika, M.; Shiva
Reddy, M.; Sunitha, M.; Nirmala, A.
Kumar, A.; Tiwari, B.K.; Sultana, S.; Kumar, S.
Mahesh, N.; Gnanaprakash, K.; Kumar, B.; Praveen, N.; Sarkar Rao, K.; Gobinath, M.
Swain, R.P.;Nagamani, R.; Panda, S.
Chinnala, K.M.; Panigrahy, R.N.; Bantu, R.; Kallem, G.R.
Daniel, J.S.P.; Veronez, I.P.; Trevisan, M.G.; Garcia, J.S.

Satyanarayana, K.; Sahoo, C.K.; Bhargavi, G.; Sahoo, N.K.
Arella, S.; Subrahmanyam, P.V.R.S.; Thadkala, K.; Das, S.; Patnaik, D.; Aukunuru, J.
Ganesh Kumar, Y.; Sreekanth, J.; Satyavati, D.
Kathiravan, P.; Pandey, V.P.
Chadha, R.; Bhandari, S.
Chidambaram, M.; Krishnasamy, K.
Jangde, R.; Singh, D.
Sachin, T.V.; Deodhar, M.N.; Prakya, V.
Ahmed, A.B.; Kanta Nath, L.
Li, J.; Lin, H.; Gu, C.; Mantik, P.; Gee, S.; Yehl, P.
Gyana Jyothi Reddy, N.; Padmalatha, H.
Khan, A.B.; Thakur, R.S.
Sharma, D.; Singh, M.; Kumar, D.; Singh, G.; Rathore, M.S.
Schou-Pedersen, A.M.V.; Hansen, S.H.; Moesgaard, B.; Østergaard, J.
Jagdale, S.C.; Phule, P.S.; Chavan, G.J.
Philip, A.K.; Philip, B.; Al Senani, H.

Sappidi, S.; Thadkala, K.; Kota, J., Aukunuru, J.
Tadudari, A.; Thadkala, K.; Devara, R.K., Aukunuru, J.
Shaker, D.S.; Ghorab, M.K.; Klingner, A.; Teiama, M.S.
Bansal, S.; Aggarwal, G.; Chandel, P.; Harikumar, S.L.
Mazurek-Wadołkowska, E.; Winnicka, K.; Czajkowska-Kośnik, A.; Czyzewska, U.; Miltyk,

W.
Hussain, T.; Saeed, T.; Mumtaz, A.M; Javaid, Z.; Abbas, K.; Awais, A.; Idrees, H.A.
Prasanthi, C.H.; Prasanthi, N.L.; Deepika, K.
Kumar, K.K.; Narasimha Reddy, M.; Naga Kishore, R.
Setyawan, D.; Widjaja, B.; Sari, R.
Govindasamy, G.; Krishnamoorthy, K.; Rajappan, M.
Singh, A.V.; Nath, L.K.
Hiremath, J.G.; Khamar, N.S.; Palavalli, S.G.; Rudani, C.G.; Aitha, R.; Mura, P.
Venkata Ratnam, G.; Ravi, G.; Harish, G.; Duraivel, S.; Pragati Kumar, B.
Pathan, I.B.; Shingare, P.R.; Kurumkar, P.
Prathima Srinivas, M.; Chaitanya, N.
Anisree, G.S.; Ramasamy, C.; John Wesley, I.

Ramana, G.; Pathan, M.K.; Sahithi, G.; Sindhu, N.; Priyanka, G.
Jagdale, S.C.; Patil, S.A.; Kuchekar, B.S.
Yener, G.; Naser, A.; Üner, M.; Barla, A.
Narang, A.S.; Desai, D.; Badawy, S.
Murthy, T.E.G.K.; Bala Vishnu Priya, M.; Suresh Babu, V.V.
Venkateswara Rao, T.; Vidyadhara, S.; Sambasivarao, K.R.S.
Rus, L.M.; Tomuta, I.; Iuga, C.; Maier, C.; Kacso, I.; Borodi, G.; Bratu, I.; Bojita, M.
Saritha, D.; Sathish, D; Madhusudan Rao, Y.
Aboud, H.M.; Ali, A.A.; Abd Elbary, A.
Rao, M.R.P.; Bachhav, D.G.; Rode, R.B.; Nikam, K.R.; Pathade, N.D.
Marques, L.M.M.; de Medeiros, M.G.F.; Nunes, L.C.C.; Citó, A.M.G.L.; Lopes, J.A.D.;
Souza, A.A.; Souza, C.M.L.
Jangde, R.; Daharwal, S.J.
Pani, N.R.; Nath, L.K.; Acharya, S.
Ajay, S.; Pradeep, K.; Anuj, M.; Dhirender, M.S.; Rajib, B.K.
Sunitha, S.; Amareshwar, P.; Santhosh Kumar, M.; Chakravarti, P.
Yener, G.; Üner, M.; Gönüllü, Ü.; Yildirim, S.; Kiliç, P.; Aslan, S.S.; Barla, A.
Sunitha, S.; Amareshwar, P.; Santhosh Kumar, M.
Gupta, V.; Shukla, S.K.; Shrivastava, S.M.; Shukla, S.; Kumar, K.; Saxena, D.P.;
Shrivastava, B.; Chaudhary, M.
Wu, Y.; Dali, M.; Gupta, A.; Raghavan, K.
Dong, Z.; Choi, D.S.
Mutalik, S.; Manoj, K.; Reddy, M.S.; Kushtagi, P.; Usha, A.N.; Anju, P.; Ranjith, A.K.;
Udupa, N.
PUBLICACION COLCIENCIAS FACTOR DE IMPACTO (F.I) ÍNDICE H
2018 2.933
2017 2.295
2017 1.45
2017 0
2017 0.261
2017 5.657
2017 2.05
2017 0.618
2017 0.66
2017 0.618
2017 0.298
2017 1.45
2016 LIBRO
2016 2.451
2016 0.404
2016 0.212
2016 0.817
2016 0.25
2016 0.817
2016 0.745
2016 4.44
2016 0.369
2016 0.302
2016 1.96
2016 2.295
2016 0.506
2016 2.531
2016 0.66
2016 0.369
2016 0.298
2016 0.745
2015 1.194
2015 0.302
2015 0.013
2015 3.649
2015 3.255
2015 0.618
2015 2.295
2015 2.531
2015 2.531
2015 0.302
2015 1.96
2015 3.002
2015 0.302
2015 0.669
2015 0.185
2015 0.134
2015 1.96
2015 1.96
2015 0.302
2014 0.302
2014 3.255
2014 2.05
2014 0.09
2014 0.163
2014 0.506
2014 0.311
2014 0.163
2014 1.96
2014 0.25
2014 2.933
2014 0.506
2014 0.506
2014 1.96
2014 2.531
2013 0.506
2013 0.76
2013 0.745
2013 0.745
2013 0.09
2013 0.618
2013 0.506
2013 0.506
2013 5.657
2013 2.302
2013 0.193
2013 0
2013 0.245
2012 0.506
2012 0.09
2012 0.618
2012 1.348
2012 3.002
2012 0.013
2012 0.09
2012 1.348
2012 0.669
2012 1.194
2011 0.09
2011 0.298
2011 0.09
2011 1.288
2011 3.002
2011 0
2010 1.133
2010 0.618
2010 0.735
2009 1.86
2008 2.451
2008 0.302
DOI DESCRAGADO
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No. REVISTA
Drug development and industrial

1 pharmacy
2 Artificial cells, nanomedicine, and

biotechnology
3 Journal of pharmaceutical innovation
4 Pharmaceutical nanotechnology
5 AAPS PharmSciTech
International journal of molecular

6 sciences
7 Advances in colloid and interface

science

8 pharmacy
9 International journal of biological

macromolecules
Materials science & engineering. C,

10 Materials for biological applications
11 Journal of pharmaceutical sciences
12 Advanced pharmaceutical bulletin
Journal of pharmaceutical and

13
biomedical analysis
International journal of pharmaceutical

14
investigation
Applied biochemistry and

15
biotechnology
16 International journal of pharmaceutics
19 Journal of nanobiotechnology

20
investigation

21
biomedical analysis
23 Journal of pharmaceutics
Daru : journal of Faculty of Pharmacy,

24 Tehran University of Medical Sciences
25 Pharmaceutical development and

technology
26 Acta chimica Slovenica

technology
Pharmaceutical development and

30
technology
The Journal of pharmacy and

31
pharmacology

33
biomedical analysis
34 Blood
35 Pharmaceutics
36 Journal of drug targeting
International journal of biological

37
macromolecules

38 investigation
39 International journal of nanomedicine
40 BioMed research international
41 Journal of drug delivery
42 Current drug delivery
43 Planta medica
45 Iranian journal of pharmaceutical

research : IJPR
Zhongguo Zhong yao za zhi =

47 Zhongguo zhongyao zazhi = China
journal of Chinese materia medica
Journal of advanced pharmaceutical
48 technology & research
49 Journal of drug delivery
50 Planta medica
51 TheScientificWorldJournal
Indian journal of pharmaceutical

53
sciences
54 Current vascular pharmacology
55 BioMed research international
56 Drug delivery
57 Drug delivery
58 Journal of biomedical nanotechnology
59 International journal of pharmaceutical

investigation
60 Journal of pharmaceutics
Saudi pharmaceutical journal : SPJ : the

61 official publication of the Saudi
Pharmaceutical Society
Journal of pharmacy & bioallied

62
sciences

63
sciences
64 Drug discoveries & therapeutics
65 Journal of ethnopharmacology

66
Tehran University of Medical Sciences

67
technology

68
technology & research

69
sciences
European journal of pharmaceutical

71 sciences : official journal of the
European Federation for

72 pharmacy
73 Artificial cells, nanomedicine, and

biotechnology
European journal of pharmaceutics and
biopharmaceutics : official journal of
74 Arbeitsgemeinschaft fur
Pharmazeutische Verfahrenstechnik
e.V

technology
76 Journal of cosmetic science
77 Journal of AOAC International
78 Journal of young pharmacists

80 pharmacy

82
macromolecules
Supportive care in cancer : official

83 journal of the Multinational
Association of Supportive Care in
Cancer
The Cochrane database of systematic

84
reviews

85
biomedical analysis
86 Acta poloniae pharmaceutica
European review for medical and

88 pharmacological sciences
90 Analytica chimica acta
Medical science monitor : international

91 medical journal of experimental and
clinical research
Journal of the mechanical behavior of

92
biomedical materials

94
macromolecules
95 Colloids and surfaces. B, Biointerfaces

96 Anesthesia and analgesia

97
Materials for biological applications
American journal of health-system

98
pharmacy
100 Postgraduate medicine

102 Journal of ethnopharmacology

Journal of materials science. Materials

104 in medicine
105 Analytical and bioanalytical chemistry

109 Planta medica
110 Journal of palliative medicine
111 European journal of anaesthesiology

112 technology

113
pharmacy

114
pharmacy
115 Journal of analytical toxicology

117
pharmacy
Spectrochimica acta. Part A, Molecular

118 and biomolecular spectroscopy
119 Journal of clinical and diagnostic

research : JCDR
121 Bioconjugate chemistry

122
macromolecules

Artificial cells, nanomedicine, and

126
biotechnology
127 Expert opinion on drug delivery


131 Colloids and surfaces. B, Biointerfaces
132 Drug design, development and therapy

133
pharmacy
135 Drug design, development and therapy

136 technology
137 Drug development and industrial

pharmacy

139 PDA journal of pharmaceutical science

and technology

140

143
technology
144 Journal of biomaterials applications

145
146 Pharmacognosy research

147
technology

148
technology
149 Die Pharmazie
150 Chemical & pharmaceutical bulletin

151 Arbeitsgemeinschaft fur
Pharmazeutische Verfahrenstechnik
e.V
TITULO
Upgrading of dissolution and anti-hypertensive effect of Carvedilol via two combined

approaches: self-emulsification and liquisolid techniques
Fabrication of Niclosamide loaded solid lipid nanoparticles: in vitro characterization and

comparative in vivo evaluation.
Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC
for HIV prevention
A self- nanoemulsifying drug delivery system for poorly water soluble tolbutamide:
development, optimization and pharmacodynamic studies.
Commentary: Why Pharmaceutical Scientists in Early Drug Discovery Are Critical for Influencing
the Design and Selection of Optimal Drug Candidates
Comparative Solid-State Stability of Perindopril Active Substance vs. Pharmaceutical

Formulation
Adsorption of poly(ethylene oxide)-containing amphiphilic polymers on solid-liquid interfaces:

Fundamentals and applications.
Solid effervescent formulations as new approach for topical minoxidil delivery.
Radiation formation of functionalized polysaccharide-protein based skin mimicking semi- inter

penetrating network for biomedical application
Evaluation of in-vitro cytotoxicity and cellular uptake efficiency of zidovudine-loaded solid lipid
nanoparticles modified with Aloe Vera in glioma cells
Dehydration and Stabilization of a Reactive Tertiary Hydroxyl Group in Solid Oral Dosage Forms
of BMS-779788
Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and ex

vivo Evaluation
Solid state compatibility study and characterization of a novel degradation product of

tacrolimus in formulation
Formulation Development and evaluation of fast disintegrating tablets of Lamotrigine using

liqui-solid technique
Detergent-compatible bacterial amylases

In vivo evaluation and in-depth pharmaceutical characterization of a rapidly dissolving solid
ocular matrix for the topical delivery of timolol maleate in the rabbit eye model
Development of protocol for screening the formulation components and the assessment of
common quality problems of nano-structured lipid carriers
Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse
transcriptase inhibitor
Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of

curcumin
Development and evaluation of a novel biodegradable sustained release microsphere

formulation of paclitaxel intended to treat breast cancer
Drug-excipient compatibility screening--role of thermoanalytical and spectroscopic techniques
Long chain lipid based tamoxifen NLC. Part I: preformulation studies, formulation development
and physicochemical characterization
Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles

to Improve the Oral Bioavailability
Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier

sucrose fatty acid ester.
Solid-state compatibility screening of excipients suitable for development of indapamide

sustained release solid-dosage formulation
Using different experimental designs in drug-excipient compatibility studies during the

preformulation development of a stable solid dosage formulation
Evaluation of hypericin-loaded solid lipid nanoparticles: physicochemical properties,

photostability and phototoxicity
A preformulation study of a new medicine for Chagas disease treatment: physicochemical

characterization, thermal stability, and compatibility of benznidazole
Stability of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in combination.
Understanding drug-excipient compatibility: oxidation of compound A in a solid dosage form.
Compatibility of chewing gum excipients with the amino acid L-cysteine and stability of the
active substance in directly compressed chewing gum formulation
Optimization studies on design and evaluation of orodispersible pediatric formulation of
indomethacin
Compatibility studies between mannitol and omeprazole sodium isomers
CD38 antibodies in multiple myeloma: back to the future
Development and Validation of an UPLC-MS/MS Method for Pharmacokinetic Comparison of

Five Alkaloids from JinQi Jiangtang Tablets and Its Monarch Drug Coptidis Rhizoma
Translation of Combination Nanodrugs into Nanomedicines: Lessons Learned and Future

Outlook
Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in

vitro and in vivo evaluations
Formulation development and evaluation of zolmitriptan oral soluble films using 2(2) factorial
designs
Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of

terconazole: development, in vitro and in vivo studies
Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity and In Vivo
Evaluation
Development of Oral Dissolvable Films of Diclofenac Sodium for Osteoarthritis Using Albizia
and Khaya Gums as Hydrophilic Film Formers
Development and Optimization of Dual Drugs (Isoniazid and Moxiflox-acin) Loaded Functional
PLGA Nanoparticles for the Synergistic Treatment of Tuberculosi
Development of Bilayer Tablets with Modified Release of Selected Incompatible Drugs
Development and Evaluation of Biodegradable Chitosan Films of Metronidazole and

Levofloxacin for the Management of Periodontitis
Design and Comparative Evaluation of In-vitro Drug Release, Pharmacokinetics and Gamma
Scintigraphic Analysis of Controlled Release Tablets Using Novel pH Sensitive Starch and
Modified Starch-acrylate Graft Copolymer Matrices
QbD-Enabled Development of Novel Stimuli-Responsive Gastroretentive Systems of Acyclovir

for Improved Patient Compliance and Biopharmaceutical Performanc
Advance in modern studies on compatibility of Coptidis Rhizoma and Evodiae Fructus

Development of subcutaneous sustained release nanoparticles encapsulating low molecular
weight heparin
Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate,

cetirizine hydrochloride in combined pharmaceutical dosage form: a new era in novel drug
delivery for pediatrics and geriatrics
Prospects of boswellic acids as potential pharmaceutics
Gastroretentive pulsatile release tablets of lercanidipine HCl: development, statistical

optimization, and in vitro and in vivo evaluation
Novel in situ gelling ocular films for the opioid growth factor-receptor antagonist-naltrexone
hydrochloride: fabrication, mechanical properties, mucoadhesion, tolerability and stability
studies
Development and Evaluation of Melt-in-Mouth Tablets of Metoclopramide Hydrochloride Using

Novel Co-processed Superdisintegrants
Recent Pharmacokinetic Studies in Combination Therapies for Diabetes and Related Vascular
Complications
Development and characterization of in situ oral gel of spiramycin
QbD-enabled systematic development of gastroretentive multiple-unit microballoons of

itopride hydrochloride
Effect of polydimethylsiloxane and ethylcellulose on in vitro permeation of centchroman from

its transdermal patches
Development and characterization of pilocarpine loaded Eudragit nanosuspensions for ocular

drug delivery
Development and evaluation of chitosan based oral controlled matrix tablets of losartan
potassium
Development of Orodispersible Tablets of Candesartan Cilexetil- β -cyclodextrin Complex
Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline:

development, characterization, and performance evaluation
Development and characterisation of thermo reversible mucoadhesive moxifloxacin

hydrochloride in situ ophthalmic gel
Development of Orodispersible Tizanidine HCl Tablets Using Spray Dried Coprocessed Exipient
Bases
Development and characterization of local anti-inflammatory implantation for the controlled
release of the hexane extract of the flower-heads of Euryops pectinatus L. (Cass.
Kinetics of aristolochic acid I after oral administration of Radix Aristolochiae or Guanxinsuhe

preparation in canines
Improved bioavailability through floating microspheres of lovastatin
Design and optimization of a stomach-specific drug delivery system of repaglinide: application

of simplex lattice design
Design and development of hydrogel nanoparticles for mercaptopurine
Topical formulations of serratiopeptidase: development and pharmacodynamic evaluation
Multiunit floating drug delivery system of rosiglitazone maleate: development,

characterization, statistical optimization of drug release and in vivo evaluation
Preformulation studies of ceftriaxone for pediatric non-parenteral administration as an

alternative to existing injectable formulations
Preparation of benznidazole pellets for immediate drug delivery using the extrusion
spheronization technique
Preliminary studies for the development of intranasal nanoemulsion containing CNS agent:
emphasizing the utilization of cut and weigh method
Preformulation studies and optimization of sodium alginate based floating drug delivery system
for eradication of Helicobacter pylori
Physicochemical characterization of native glycyl-l-histidyl-l-lysine tripeptide for wound healing

and anti-aging: a preformulation study for dermal delivery
Drug-excipient compatibility studies in binary mixtures of avobenzone
Application of chemometrically processed thermogravimetric data for identification of

baclofen-excipient interactions
Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy

Propyl Methyl Cellulose as Rate-controlling Polymer
Clotrimazole nanoemulsion for malaria chemotherapy. Part I: preformulation studies,

formulation design and physicochemical evaluation
Development and evaluation of a pH-dependent sustained release tablet for irritable bowel
syndrome
Preformulation considerations for controlled release dosage forms. Part II. Selected candidate
support
Effect of crosslinker on drug delivery properties of curcumin loaded starch coated iron oxide
nanoparticles
Multidrug infusions in a Swiss palliative care unit: assessment of frequent combinations in

terms of clinical effectiveness, compatibility, and stability
Oral non-steroidal anti-inflammatory drugs (single dose) for perineal pain in the early
postpartum period
Microdialysis combined with UPLC-MS/MS method for determination of tetramethylpyrazine

and ferulic acid in striatum of awake and anesthetic rats subjected to cerebral ischemia
STUDYING THE IMPACT OF FORMULATION AND PROCESSING PARAMETERS ON THE RELEASE

CHARACTERISTICS FROM HYDROXYPROPYL METHYLCELLULOSE MATRIX TABLETS OF
DICLOFENAC
Sustained Anti-inflammatory Effect of Resveratrol-Phospholipid Complex Embedded Polymeric

Patch
Anti-inflammatory effects exerted by Killox®, an innovative formulation of food supplement

with curcumin, in urology
New Thermoresponsive Eyedrop Formulation Containing Ibuprofen Loaded-Nanostructured

Lipid Carriers (NLC): Development, Characterization and Biocompatibility Studies
A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple

applications
Period Prevalence of Ketamine-Propofol Admixture "Ketofol" in the Operating Room among

Anesthesia Providers at an Academic Medical Center
Mechanical, thermal and bio-compatibility studies of PAEK-hydroxyapatite nanocomposites
In vitro and in vivo evaluation of Δ⁹-tetrahidrocannabinol/PLGA nanoparticles for cancer

chemotherapy
Modified hydroxypropyl methyl cellulose: Efficient matrix for controlled release of 5-amino
salicylic acid
Nano-anisotropic surface coating based on drug immobilized pendant polymer to suppress

macrophage adhesion response
Analysis of remifentanil with liquid chromatography-tandem mass spectrometry and an
extensive stability investigation in EDTA whole blood and acidified EDTA plasma
The optimal extracting process, manufacturing technique and biological evaluation of

Lithospermum erythrorhizon microcapsules
Stability of clonidine suspension in oral plastic syringes
Pretreatment with skin permeability enhancers: importance of duration and composition on

the delivery of diclofenac sodium
A review of the compatibility of liposome bupivacaine with other drug products and commonly
used implant materials
Study on efficacy of compatibility between aconiti radix cocta and Pinelliae Rhizoma on basis of
uniform design method
Elucidation of the transport mechanism of baicalin and the influence of a Radix Angelicae
Dahuricae extract on the absorption of baicalin in a Caco-2 cell monolayer model
Change in dissolution of chemical components of frankincense-myrrh before and after their

compatibility and effect on no release of LPS-induced macrophage cells
Design and in vitro evaluation of transdermal patches based on ibuprofen-loaded electrospun

fiber mats
Chemometric approach for development, optimization, and validation of different

chromatographic methods for separation of opium alkaloids
Evaluation of ionotropic cross-linked chitosan/gelatin B microspheres of tramadol

hydrochloride
Development and characterization of eudragit RS 100 loaded microsponges and its colonic
delivery using natural polysaccharide
Studies on pharmacokinetics of ferulic acid, Rhizoma Chuanxiong and Naodesheng capsule in

rat
The evaluation of ketoprofen pharmaceutical availability in the presence of a dry extract from
goldenrod (Solidago virgaurea L.) of synthetic polymer vehicles
Compatibility and stability of ternary admixtures of tramadol, haloperidol, and hyoscine N-butyl
bromide: retrospective clinical evaluation
Compatibility and stability of binary mixtures of acetaminophen, nefopam, ketoprofen and

ketamine in infusion solutions
Formulation and evaluation of curcumin gel for topical application
Design and evaluation of transdermal drug delivery system for curcumin as an anti-
inflammatory drug
Carboxymethyl mungbean starch as a new pharmaceutical gelling agent for topical preparation
Simultaneous determination of ketamine, tramadol, methadone, and their metabolites in urine

by gas chromatography-mass spectrometry
The development of microthermal analysis and photothermal microspectroscopy as novel

approaches to drug-excipient compatibility studies
Design and evaluation of mucoadhesive vaginal tablets of tenofovir disoproxil fumarate for pre-
exposure prophylaxis of HIV
A novel spectroscopic analysis to detect photochemical reaction of the bronchodilator -

Doxofylline and its estimation in pharmaceutical formulation
Formulation and Evaluation of Sol-Gel Drug Delivery System for Intracanal pH Sensitive
Controlled Delivery of Chlorhexidine
Influence of Peroxide Impurities in Povidone on the Stability of Selected β-Blockers with the
Help of HPLC
Pseudopolyrotaxane Formation in the Synthesis of Cyclodextrin Polymers: Effects on Drug

Delivery, Mechanics, and Cell Compatibility
Sustained release gastroretentive tablet of metformin hydrochloride based on poly (acrylic

acid)-grafted-gellan
A pragmatic approach to the analysis of a combination formulation
Delivery of Thermoresponsive-Tailored Mixed Micellar Nanogel of Lidocaine and Prilocaine with

Improved Dermatokinetic Profile and Therapeutic Efficacy in Topical Anaesthesia
OLANZAPINE-PEG 6000 BINARY SYSTEMS: IN VITRO DISSOLUTION BEHAVIOR,

PHYSICOCHEMICAL CHARACTERIZATION AND MATHEMATICAL MODELING
Preparation and characterization of isoniazid and lamivudine co-loaded polymeric microspheres
Design and development of controlled release floating matrix tablet of Nicorandil using
hydrophilic cellulose and pH-independent acrylic polymer: in-vitro and in-vivo evaluations
Application of Central Composite Design in Optimization of Valsartan Nanosuspension to
Enhance its Solubility and Stability
Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of
buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies
Formulation Development of Spherical Crystal Agglomerates of Itraconazole for Preparation of

Directly Compressible Tablets with Enhanced Bioavailability
Nevirapine loaded Poloxamer 407/Pluronic P123 mixed micelles: Optimization of formulation

and in vitro evaluatio
An optimized probucol microencapsulated formulation integrating a secondary bile acid

(deoxycholic acid) as a permeation enhance
Formulation and evaluation of floating tablet of H2-receptor antagonist
Pharmaceutical and pharmacokinetic evaluation of a novel fast dissolving film formulation of

flupentixol dihydrochloride
Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid

formulation: a characterization study
Solid-state stability and compatibility studies of clavulanate potassium
Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix

forming excipient for controlled drug delivery
characterization
Studies on stercuia gum formulations in the form of osmotic core tablet for colon-specific drug
delivery of azathioprine
Compatibility studies of nevirapine in physical mixtures with excipients for oral HAART
Development of novel floating delivery system based on psyllium: application on metformin

hydrochloride
A compatibility study of a secondary amine active pharmaceutical ingredient with starch:

identification of a novel degradant formed between desloratadine and a starch impurity using
LC-MS(n) and NMR spectroscopy
Effect of different polymers and their combinations on the release of metoclopramide HCl from
sustained-release hydrophilic matrix tablets
In vitro cytotoxicity and cellular uptake of curcumin-loaded Pluronic/Polycaprolactone micelles
in colorectal adenocarcinoma cells
Lornoxicam gastro retentive floating matrix tablets: Design and in vitro evaluation
Design and development of a stable polyherbal formulation based on the results of

compatibility studies
The solution, solid state stability and kinetic investigation in degradation studies of
lercanidipine: study of excipients compatibility of lercanidipine
In vitro characterization and release study of Ambroxol hydrochloride matrix tablets prepared
by direct compression
Thermal and non-thermal methods to evaluate compatibility of granisetron hydrochloride with

tablet excipients
Design and in vitro evaluation of zidovudine oral controlled release tablets prepared using
hydroxypropyl methylcellulose
Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-beta-

cyclodextrin
AUTOR PRINCIPAL AUTOR (ES) IDIOMA
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Singh B, Kumar A. Inglés
K S J, Sharma CP, Kalarikkal N, Sandeep K, Thomas S,

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Moosa RM, Choonara YE, du Toit LC, Tomar LK, Tyagi C,
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Zhang W, Parniak MA, Sarafianos SG, Cost MR, Rohan LC. Inglés
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Shiny J, Ramchander T, Goverdhan P, Habibuddin M,

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Chadha R, Bhandari S Inglés
Shete H, Patravale V. Inglés
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Sunil SA, Srikanth MV, Rao NS, Raju V, Murthy KV Inglés
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Bonsu MA, Ofori-Kwakye K, Kipo SL, Boakye-Gyasi ME, Inglés

Fosu MA
Moin A, Raizaday A, Hussain T, Nagshubha B Inglés
Dhiman N, Awasthi R, Jindal S, Khatri S, Dua K Inglés
Khan G, Yadav SK, Patel RR, Nath G, Bansal M, Mishra B Inglés
Kumar P, Ganure AL, Subudhi BB, Shukla S Inglés
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Qiu C, Cui YL, Qi XJ, Jiang HL, Wang QS. Inglés

Jogala S, Rachamalla SS, Aukunuru J Inglés
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Du Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A Inglés
Reddy GS, Nayak UY, Deshpande PB, Mutalik S Inglés
Abdelkader H, Pierscionek B, Alany RG Inglés
Ladola MK, Gangurde AB Inglés
Lu HQ, Lu W, Liu J, Yang KJ, Li ZG Inglés
Sharma A, Sharma J, Kaur R, Saini V Inglés
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Singh B Inglés
Gupta V, Singh S, Srivarstava M, Ahmad H, Pachauri SD, Inglés

Khandelwal K, Dwivedi P, Dwivedi AK
Khan MS, Vishakante GD, Bathool A Inglés
Rao TV, Kumar GK, Ahmed MG, Joshi V Inglés
Sravya M, Deveswaran R, Bharath S, Basavaraj BV,

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Gupta A, Aggarwal G, Singla S, Arora R Inglés
Dholakia M, Thakkar V, Patel N, Gandhi T Inglés
Masareddy R, Kokate A, Shah V Inglés

Nesseem DI, Michel CG Inglés
Yang HY, Zheng XH, Du Y, Chen Z, Zhu DY, Lou YJ Inglés
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Kumar A, Jain SK Inglés
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Zhang SQ, Rahman Z, Thumma S, Repka MA, Chen GH, Li
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Saikia C, Das MK, Ramteke A, Maji TK Inglés
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Habib WA, Sakr A Inglés
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Almeida H, Lobão P, Frigerio C, Fonseca J, Silva R, Inglés

Palmeira-de-Oliveira A, Lobo JM, Amaral MH
Wang Q, Ye M, Xu L, Shi ZG Inglés
Olson AN, Rao WR, Marienau ME, Smischney NJ Inglés
Roy P, Sailaja RR Inglés
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Fuentes J, Calderón-Montaño JM, López-Lázaro M, Arias Inglés
JL, Leiva MC, Holgado MA, Fernández-Arévalo M
Das R, Pal S Inglés
Kaladhar K, Renz H, Sharma CP Inglés

Koster RA, Vereecke HE, Greijdanus B, Touw DJ, Struys
MM, Alffenaar JW Inglés
Lou CW, Chang CY, Wu ZH, Lin JH Inglés
Ma C, Decarie D, Ensom MH Inglés
Maurya A, Murthy SN Inglés
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Liu CF, Tan SF, Wang DH, Zhang YQ, Lin N Inglés
Zhu ML, Liang XL, Zhao LJ, Liao ZG, Zhao GW, Cao YC,
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Chen T, Su SL, Duan JA, Shang EX, Qian DW, Tang YP Inglés
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Patel NA, Patel NJ, Patel RP Inglés
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Mubtasim N, Kabir ER, Podder AK, Bhadra S Inglés
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Kesarla RS, Vora PA, Sridhar BK, Patel G, Omri A Inglés
Abdelbary A, Bendas ER, Ramadan AA, Mostafa DA Inglés
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Rathnanand M, Narkhede R, Udupa N, Kalra A Inglés
Yu X, Buevich AV, Li M, Wang X, Rustum AM Inglés
Savaşer A, Taş Ç, Bayrak Z, Özkan CK, Özkan Y Inglés

Raveendran R, Bhuvaneshwar G, Sharma CP Inglés
Sathiyaraj S, Devi RD, Hari VB Inglés
Bhope SG, Nagore DH, Kuber VV, Gupta PK, Patil MJ Inglés
Parmar N, Amin S, Singla N, Kohli K Inglés
Abd-Elbary A, Haider M, Sayed S Inglés
Late SG, Banga AK Inglés
Ravi PR, Ganga S, Saha RN Inglés
Corti G, Cirri M, Maestrelli F, Mennini N, Mura P Inglés

AÑOS DE REVISTA INDEXADA CATEGORIA-
2007 2.295
2017 5.605
2017 2.243
2017 NOT FOUND
2018 2.451
2017 3.226
2017 7.223
2017 2.295
2016 3.671
2016 4.164
2016 2.933
2015 2.05
2015 3.255
2014 0.817
2014 1.751
2014 3.649
2014 3.649
2014 3.649
2013 4.946
2013 0.817
2013 3.255
2013 3.649
2013 NOT FOUND
2013 1.653
2013 1.86
2010 0.983
2012 1.86
2010 2.451
2010 2.451
2009 1.86
2008 2.405
2008 2.451
2008 3.255
2017 13.164
2017 3.83
2017 3.068
2017 3.671
2016 0.817
2016 4.3
2016 2.476
2016 0
2016 2.391
2016 2.342
2016 2.451
2015 1.507
2016 2.451
2015 0.247
2015 1.683
2015 0
2015 2.342
2014 1.524
2014 3.649
2014 0.66
2015 2.391
2014 2.476
2016 6.402
2016 6.402
2013 4.521
2012 0.817
2013 NOT FOUND
2012 2.302
2012 0.76
2011 0.66
2011 1.648
2011 2.981
2011 1.653
2012 1.86
2010 1.683
2010 0.66
2009 2.451
2017 3.756
2017 2.295
2017 5.605
2015 4.159
2016 1.86
2013 0.222
2012 0.962
2012 0.404
2012 3.649
2009 2.295
2008 2.451
2016 3.671
2016 2.698
2016 6.264
2016 3.255
2016 0.745
2017 2.451
2016 1.778
2016 2.391
2015 4.95
2015 1.585
2015 3.11
2015 3.649
2015 3.671
2015 3.887
2015 4.014
2015 4.164
2014 1.969
2014 2.933
2014 2.062
2013 0.247
2013 2.981
2013 0.247
2013 2.325
2012 3431
2011 2.451
2010 0.745
2010 0.247
2009 2.342
2010 2.23
2009 3.57
2009 1.86
2009 2.295
2009 2.295
2008 2.409
2008 3.649
2017 2.295
2018 2.536
2017 0.765
2017 2.451
2017 4.818
2017 3.671
2017 2.302
2017 2.451
2015 0.745
2016 5.605
2016 5.657
2016 2.391
2015 2.302
2015 2.451
2015 3.887
2014 2.822
2015 2.295
2014 2.451
2014 2.822
2015 1.86
2013 2.295
2013 2.302
2013 0.393
2013 4.164
2013 2.391
2013 2.933
2013 1.86
2013 2.31
2011 1.683
2011 1.188
2012 1.86
2012 1.86
2008 1.126
2008 1.133
2008 4.159
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10.4103/2230-973X.119212 No
10.1016/j.jpba.2013.06.016 No
10.1016/j.ijpharm.2013.03.034 No
10.1155/2013/265741 No
10.1186/1560-8115-20-4 No
10.3109/10837450.2012.717948 No
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10.4103/2230-973X.104399 No
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No. REVISTA
Brazilian Journal of Pharmaceutical

1 Sciences
2 Brazilian Journal of Pharmaceutical

Sciences
3 Química Nova
4 Revista Cubana de Farmacia
7 Revista Brasileira de Ciências

Farmacêuticas
Revista de la Sociedad Española del

8 Dolor
9 Revista da Sociedade Brasileira de

Medicina Tropical
TITULO
Compatibility and stability of valsartan in a solid pharmaceutical formulation
Floating tablets of hydralazine hydrochloride: optimization and evaluation
Análise térmica aplicada à caracterização da sinvastatina em formulações farmacêuticas
Síntesis, caracterización fisicoquímica y del estado sólido de asparaginatos de cobre,

magnesio, manganeso y zinc
Compatibilidad química del piracetam determinada por calorimetría diferencial de barrido
Compatibilidad química por calorimetría diferencial de barrido y termogravimetría del

auranofin tabletas 3 mg
Avaliação das propriedades de fluxo dos granulados e dissolução de comprimidos de

hidroclorotiazida 50 mg obtidos por granulação úmida
La sinergia farmacológica aplicada a la analgesia: revisión de la combinación de ibuprofeno con

codeína
Perfil de dissolução in vitro de comprimidos de primaquina disponíveis para tratamento de

malária no Brasil
AUTOR PRINCIPAL
Marcello Garcia Trevisan
Kondi Vanitha
Marcelo Antonio de Oliveira
Julie Fernanda Benavides

Arévalo
Luis Octavio Martínez Álvarez
Luis Octavio Martínez Álvarez
Marco Aurélio Lamolha
J.R. González-Escalada
Humberto Gomes Ferraz

AUTOR (ES) IDIOMA
Júlio, Tamíris Amanda; Zâmara, Igor Fernando; Garcia, Jerusa Simone; Trevisan,
Marcello Garcia INGLÉS
Vanitha, Kondi; Varma, Mohan; Ramesh, Alluri INGLÉS
Oliveira, Marcelo Antonio de; Yoshida, Maria Irene; Gomes, Elionai Cassiana de Lima;
Mussel, Wagner da Nova; Vianna-Soares, Cristina Duarte; Pianetti, Gérson Antônio PORTUGUÉS
Benavides Arévalo, Julie Fernanda; Tobón Zapata, Gloria Elena ESPAÑOL
Martínez Álvarez, Luis Octavio; Mena Salabarría, Keila; Céspedes Pérez, Mirelys ESPAÑOL
Martínez Álvarez, Luis Octavio; Montes Pérez, Marlene ESPAÑOL
Lamolha, Marco Aurélio; Serra, Cristina Helena dos Reis PORTUGUÉS
González-Escalada, J.R. ESPAÑOL
Rodrigues, Letícia Norma Carpentieri; Ferraz, Humberto Gomes; Watanabe, Sayuri Pereira PORTUGUÉS
AÑO DE REVISTA INDEXADA CATEGORIA- FACTOR DE IMPACTO
PUBLICACION COLCIENCIAS (F.I)
2013 0.474
2013 0.474
2010 0.037
2013 0.202
2013 0.202
2011 NA 0.202
2007 NOT FOUND
2010 0.157
2008 1.161
ÍNDICE H DOI
http://www.scielo.br/pdf/bjps/v49n4/v49n4a03.pdf
http://www.scielo.br/pdf/bjps/v49n4/v49n4a21.pdf
http://www.scielo.br/pdf/qn/v33n8/07.pdf
http://scielo.sld.cu/pdf/far/v47n2/far03213.pdf
http://www.scielo.br/pdf/rbcf/v43n3/a12v43n3.pdf
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1134-80462010000100007&lang=es
http://www.scielo.br/pdf/rsbmt/v41n1/a08v41n1.pdf
DESCRAGADO
SI
SI
SI
SI
SI
SI
SI
SI
SI
No. REVISTA
1 Farmacia Hospitalaria
2 Revista Brasileira de Farmacognosia

6 Biomedical Analysis
9 Journal of Ethnopharmacology
11 Life Sciences

12
Biomedical Analysis
Asian Journal of Pharmaceutical

15
Sciences
Nanomedicine: Nanotechnology,
19
Biology and Medicine
20 Drug Discovery Today
European Journal of Pharmaceutical

24 Sciences
27 Academic Press
29 Journal of Controlled Release

30
Technology

31
Biomedical Analysis
32 Journal of Pharmaceutical Analysis
33 Drug Discovery Today
European Journal of Pharmaceutics

35
and Biopharmaceutics
Asian Journal of Pharmaceutical

37
Sciences
41 Journal of Drug Delivery Science and

Technology
42 Advanced Drug Delivery Reviews
43 Phytomedicine
45 Pharmacognosy Journal

46
Sciences

47
Technology
48 Biomedical Analysis
49 Journal of Food and Drug Analysis

52
Biomedical Analysis
European Journal of Pharmaceutics

53
and Biopharmaceutics
55 Journal of Pharmaceutical and

Biomedical Analysis

56 Sciences
57 European Journal of Pharmaceutical

Sciences
59 Journal of Pharmaceutical and

Biomedical Analysis

60
Biomedical Analysis
62 Biomedicine & Aging Pathology


67
Technology

69


72 Technology

TITULO
Estabilidad y compatibilidad de la mezcla de tramadol, ketorolaco, metoclopramida y ranitidina

en una solución para perfusión intravenosa
Development of tablets containing semipurii ed extract of guaraná (Paullinia cupana)
Synthesis, Characterization, and Crystal Chemistry of Tasimelteon, a Melatonin Agonist, in Its

Anhydrous and Hemihydrate Forms
Self-emulsifying excipient platform for improving technological properties of alginate–

hydroxypropylcellulose pellets
Thermal behavior and stability of biodegradable spray-dried microparticles containing

triamcinolone
Stability and in vitro release profile of enalapril maleate from different commercially available
tablets: Possible therapeutic implications
Synthesis, molecular properties, toxicity and biological evaluation of some new substituted
imidazolidine derivatives in search of potent anti-inflammatory agents
Amino acid based amphiphilic copolymer micelles as carriers of non-steroidal anti-inflammatory

drugs: Solubilization, in vitro release and biological evaluation
Naturally derived anti-inflammatory compounds from Chinese medicinal plants
Evaluation of the anti-inflammatory and analgesic properties of individual and combined

extracts from Commiphora myrrha, and Boswellia carterii
Development of novel transdermal self-adhesive films for tenoxicam, an anti-inflammatory drug
Drug–excipient compatibility screening—Role of thermoanalytical and spectroscopic

techniques
Design of an Anti-Inflammatory Composite Nanosystem and Evaluation of Its Potential for

Ocular Drug Delivery
Emu oil based nano-emulgel for topical delivery of curcumin
Preparation of highly stable diclofenac potassium pellet with microcrystalline cellulose by

extrusion–spheronization
The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum
seeds: Focus on the freeze-dried matrix forming capacity
Development of Poloxamer Gel formulations via Hot-Melt Extrusion Technology
Sponge like microparticles for drug delivery and cosmeto-textile use: Formulation and human
skin penetration
Self-assembly of a ibuprofen-peptide conjugate to suppress ocular inflammation
Multi-target approach for natural products in inflammation
An approach for rapid development of nasal delivery of analgesics—Identification of relevant

features, in vitro screening and in vivo verification
Enhancement of dissolution rate and bioavailability of aceclofenac: A chitosan-based solvent

change approach
Microsponges based novel drug delivery system for augmented arthritis therapy
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous

delivery of ibuprofen assessed in vivo in rats
Impact of in situ granulation and temperature quenching on crystal habit and micromeritic
properties of ibuprofen-cationic dextran conjugate crystanules
Solubility of Ketoprofen in colloidal PLGA
Chapter 21 - Development of Modified-Release Solid Oral Dosage Forms
Design and evaluation of bi-layer pump tablet of flurbiprofen solid dispersion for zero-order
controlled delivery
Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays

for transdermal delivery of high dose, low molecular weight drugs
Development of mucoadhesive and thermosensitive eyedrops to improve the ophthalmic

bioavailability of ibuprofen
An assessment of the interactions between diclofenac sodium and ammonio methacrylate

copolymer using thermal analysis and Raman spectroscopy
Simultaneous colorimetric determination of morphine and ibuprofen based on the aggregation
of gold nanoparticles using partial least square
Advantages and challenges offered by biofunctional core–shell fiber systems for tissue
engineering and drug delivery
Electrospun diclofenac sodium loaded Eudragit® L 100-55 nanofibers for colon-targeted drug
delivery
The effects of cryoprotectants on the freeze-drying of ibuprofen-loaded solid lipid

microparticles (SLM)
Solid-state compatibility studies using a high-throughput and automated forced degradation

system
Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability
of aspirin tablets
Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine

hydrochloride in physical mixtures
Quality by design approach for formulation development: A case study of dispersible tablets
Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets
Development and characterization of ketorolac tromethamine osmotic pump tablets
Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques
Pharmacokinetics and pharmacodynamics of glycyrrhetinic acid with Paeoniflorin after

transdermal administration in dysmenorrhea model mice
Quantitatively analyze composition principle of Ma Huang Tang by structural equation

modeling
Preparation and characterization of Beta vulgaris pulp powder as a pharmaceutical excipient
Experimental optimization of Lornoxicam liposomes for sustained topical delivery
Recrystallized agglomerated meloxicam: evaluation of anti-nociceptive effect

Determination of tramadol and metabolites by HPLC-FL and HPLC–MS/MS in urine of dogs
Triple-component nanocomposite films prepared using a casting method: Its potential in drug
delivery
Development of an enhanced formulation for delivering sustained release of buprenorphine

hydrochloride
Surface modification of acetaminophen particles by atomic layer deposition
Evaluation of supercritical fluid chromatography for testing of PEG adducts in pharmaceuticals
Influence of plasticizers on the stability and release of a prodrug of Δ9-tetrahydrocannabinol

incorporated in poly (ethylene oxide) matrices
Anti-inflammatory effect of Sanshuibaihu decoction may be associated with nuclear factor-κB

and p38 MAPKα in collagen-induced arthritis in rat
Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage
forms
Drug-excipient compatibility assessment of solid formulations containing meloxicam
Pharmaceutical excipients — quality, regulatory and biopharmaceutical considerations
Screening for stability and compatibility conditions of recombinant human epidermal growth
factor for parenteral formulation: Effect of pH, buffers, and excipients
Use of mixture design in drug-excipient compatibility determinations: Thymol nanoparticles

case study
Solid state compatibility studies with tablet excipients using non thermal methods
Nanostructured lipid carrier (NLC) based gel of celecoxib
Screening of topical gel containing lycopene and dexamethasone against UV radiation induced
photoaging in mice
Melt-Cast Noninvasive Ocular Inserts for Posterior Segment Drug Delivery

Selection of high efficient transdermal lipid vesicle for curcumin skin delivery
Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive
intestinal peptide derivative ([R15, 20, 21, L17, A24,25, des-N28]-VIP-GRR) in experimental
asthma/COPD model rats
PLA/F68/Dexamethasone implants prepared by hot-melt extrusion for controlled release of

anti-inflammatory drug to implantable medical devices: I. Preparation, characterization and
hydrolytic degradation study
Novel chewable colon targeted tablets of bumadizone calcium for treatment of ulcerative
colitis: Formulation and optimization
Improved and Safe Transcorneal Delivery of Flurbiprofen by NLC and NLC-Based Hydrogels
Development and in-vitro evaluation of controlled release matrix tablets of isradipine

employing various natural polymers
Formulation and evaluation of flupirtine maleate sustain release matrix tablets
RP-LC gradient elution method for simultaneous determination of related substances of

zaltoprofen and paracetamol and application for drug excipient compatibility study
Formulation and evaluation of zaltoprofen nanoemulsion gel
Formulation and characterisation of Tizanidine hydrochloride loaded ethosomes patch

AUTOR PRINCIPAL
Adriana Fuliaş
AUTOR (ES) IDIOMA
Cabrera, J.; Mancuso, M.; Cabrera-Fránquiz, F.; Limiñana, J.; Díez, A Español
Klein, Traudi; Longhini, Renata; Bruschi, Marcos Luciano; Palazzo de Mello, João Carlos Inglés
Ventimiglia, Giampiero; Bellomi, Sonja; Barreca, Giuseppe; Giovannelli, Lorella; Masciocchi,

Norberto Inglés
Mannina, Paolo; Segale, Lorena; Giovannelli, Lorella; Bonda, Andrea Foglio; Pattarino,
Inglés
Franco
da Silva-Junior, Arnóbio Antônio; de Matos, Jivaldo Rosário; Formariz, Thalita Pedroni;

Rossanezi, Gustavo; Scarpa, Maria Virginia; do Egito, Eryvaldo Sócrates Tabosa; de Oliveira, Inglés
Anselmo Gomes
Lima, Dione Marçal; dos Santos, Leandro Dias; Lima, Eliana Martins Inglés
Husain, Asif; Ahmad, Aftab; Khan, Shah Alam; Asif, Mohd; Bhutani, Rubina; Al-Abbasi, Inglés
Fahad A.
Dutta, Pranabesh; Dey, Joykrishna; Perumal, Venkatesan; Mandal, Mahitosh Inglés
Wang, Qiuhong; Kuang, Haixue; Su, Yang; Sun, Yanping; Feng, Jian; Guo, Rui; Chan, Kelvin Inglés
Su, Shulan; Hua, Yongqing; Wang, Yanyan; Gu, Wei; Zhou, Wei; Duan, Jin-ao; Jiang, Haifeng;
Chen, Ting; Tang, Yuping Inglés
Nesseem, Demiana I.; Eid, S.F.; El-Houseny, S.S Inglés
Chadha, Renu; Bhandari, Swati Inglés
Du Toit, Lisa C.; Govender, Thirumala; Carmichael, Trevor; Kumar, Pradeep; Choonara,
Inglés
Yahya E.; Choonara, Yahya E; Pillay, Viness
Jeengar, Manish Kumar; Rompicharla, Sri Vishnu Kiran; Shrivastava, Shweta; Chella,
Inglés
Naveen; Shastri, Nalini R.; Naidu, V.G.M.; Sistla, Ramakrishna
Wang, Yueqi; Huang, Hao; Zhang, Chungang; Tang, Yilin; Li, Jinzhuo; Tang, Xing; Cai,
Inglés
Cuifang
Iurian, Sonia; Dinte, Elena; Iuga, Cristina; Bogdan, Cătălina; Spiridon, Iuliana; Barbu-
Tudoran, Lucian; Bodoki, Andreea; Tomuţă, Ioan; Leucuţa, Sorin E Inglés
Mendonsa, Nicole S.; Murthy, S. Narasimha; Hashemnejad, Seyed Meysam; Kundu,

Inglés
Santanu; Zhang, Feng; Repka, Michael A
Zafar, Nadiah; Robin, Sophie; Viennet, Céline; Humbert, Philippe; Valour, Jean Pierre;
Inglés
Agusti, Geraldine; Fessi, Hatem; Elaissari, Abdelhamid
Yu, Xinxin; Zhang, Zhaoliang; Yu, Jing; Chen, Hao; Li, Xingyi Inglés
Koeberle, Andreas; Werz, Oliver Inglés
Wang, Shu; Chow, Moses S.S.; Zuo, Zhong Inglés
Mutalik, Srinivas; Anju, Parambil; Manoj, Krishnan; Usha, Achutha Nayak Inglés
Osmani, Riyaz Ali M.; Aloorkar, Nagesh H.; Ingale, Dipti J.; Kulkarni, Parthasarathi K.; Hani, Inglés
Umme; Bhosale, Rohit R.; Jayachandra Dev, Dandasi
Djekic, Ljiljana; Martinovic, Martina; Stepanović-Petrović, Radica; Micov, Ana; Tomić, Maja;
Primorac, Marija Inglés
bioye, Amos Olusegun; Kola-Mustapha, Adeola; Ruparelia, Ketan Inglés
Kluge, Johannes; Mazzotti, Marco; Muhrer, Gerhard Inglés
Qiu, Yihong; Zhang, Guohua Inglés
Cheng, Lizhen; Li, Ting; Dong, Ling; Wang, Xiaoyu; Huo, Qiye; Wang, Haoyu; Jang, Zhujun;
Inglés
Shan, Xinyu; Pan, Weisan; Yang, Xinggang
McCrudden, Maelíosa T.C.; Alkilani, Ahlam Zaid; McCrudden, Cian M.; McAlister, Emma; Inglés
McCarthy, Helen O.; Woolfson, A. David; Donnelly, Ryan F
Almeida, Hugo; Lobão, Paulo; Frigerio, Christian; Fonseca, Joel; Silva, Renata; Quaresma,
Inglés
Pedro; Lobo, José Manuel Sousa; Amaral, Maria Helena
Sipos, Péter; Szűcs, Mária; Szabó, András; Erős, István Inglés

Bahram, Morteza; Madrakian, Tayyebeh; Alizadeh, Sakineh Inglés
Sperling, Laura E.; Reis, Karina P; Pranke, Patricia; Wendorff, Joachim H Inglés
Shen, Xiaxia; Yu, Dengguang; Zhu, Limin; Branford-White, Christopher; White, Kenneth;
Inglés
Chatterton, Nicholas P.
Zhang, Lijuan; Liu, Lei; Qian, Yu; Chen, Yun Inglés
Wakasawa, Tatsuyoshi; Sano, Kyoko; Hirakura, Yutaka; Toyo’oka, Toshimasa; Kitamura,

Inglés
Satoshi
Wang, Xiuzhi; Wang, Puxiu; Huang, Chenglong; Lin, Xiaoyang; Gong, Haoyu; He, Haibing;
Inglés
Cai, Cuifang
de Oliveira, G.G.G.; Feitosa, A.; Loureiro, K.; Fernandes, A.R.; Souto, E.B.; Severino, P. Inglés
Charoo, Naseem A.; Shamsher, Areeg A.A.; Zidan, Ahmed S.; Rahman, Ziyaur Inglés
Tawfeek, Hesham M.; Saleem, Imran Y.; Roberts, Matthew Inglés
Ali, A.A.;Sayed, O.M. Inglés
Pindelska, Edyta; Sokal, Agnieszka; Kolodziejski, Waclaw Inglés
Ding, Xue; Sun, Yuming; Wang, Qing; Pu, Tingting; Li, Xiaohui; Pan, Yaqing; Yang, Yang Inglés
He, Yu; Gai, Yuquan; Wu, Xianbin; Wan, Haitong Inglés
Bablu, Ram; Rishabha, Malviya; Mayank, Bansal; Kumar, Sharma Pramod Inglés
Joseph, Joshny; B.N., Vedha Hari; D., Ramya Devi Inglés
Farid, M.; El-Setouhy, D.A.; El-Nabarawi, M.A.; El-Bayomi, T. Inglés

Saccomanni, G.; Del Carlo, S.; Giorgi, M.; Manera, C.; Saba, A.; Macchia, M. Inglés
Gilani, Sadia; Mir, Sadullah; Masood, Momina; Khan, Abida Kalsoom; Rashid, Rehana;
Azhar, Saira; Rasul, Akhtar; Ashraf, Muhammad Nadeem; Waqas, Muhammad Khurram; Inglés
Murtaza, Ghulam
Koocheki, S.; Madaeni, S.S.; Niroomandi, P Inglés
Kääriäinen, Tommi O; Kemell, Marianna; Vehkamäki, Marko; Kääriäinen, Marja-Leena;

Correia, Alexandra; Santos, Hélder A.; Bimbo, Luis M.; Hirvonen, Jouni; Hoppu, Pekka; Inglés
George, Steven M; Cameron, David C; Ritala, Mikko; Leskelä, Markku
Schou-Pedersen, Anne Marie V; Østergaard, Jesper; Johansson, Mats; Dubant, Stephane;

Inglés
Frederiksen, Rune B; Hansen, Steen Honoré
Thumma, Sridhar; ElSohly, Mahmoud A.; Zhang, Shuang-Qing; Gul, Waseem; Repka,
Inglés
Michael A.
Yang, Min; Xiao, Changhong; Wu, Qifu; Niu, Maochang; Yao, Qi; Li, Kaiqin; Chen, Yuyao; Shi,
Caixia; Chen, Dechao; Feng, Guokai; Xia, Chenlai
Tiţa, Bogdan; Fuliaş, Adriana; Bandur, Geza; Marian, Eleonora
da Silveira LM, Fiorot AB, Xavier TP, Yoshida MI, de Oliveira MA
Elder, David P.; Kuentz, Martin; Holm, René
Santana, Héctor; González, Yaima; Campana, Patricia Targon; Noda, Jesús; Amarantes,
Odalys; Itri, Rosangela; Beldarraín, Alejandro; Páez, Rolando
Pires, Felipe Q.; Angelo, Tamara; Silva, Joyce K.R; Sá-Barreto, Lívia C.L; Lima, Eliana M;
Gelfuso, Guilherme M; Gratieri, Tais; Cunha-Filho, Marcílio S.S
Liltorp, Karin; Larsen, Trine Gorm; Willumsen, Birgitte; Holm, René
Joshi, Medha; Patravale, Vandana
Shah, Harshit; Mahajan, Shruti Rawal
Balguri, Sai Prachetan; Adelli, Goutham R.; Tatke, Akshaya; Janga, Karthik Yadav; Bhagav,
Prakash; Majumdar, Soumyajit
Zhao, Ying-Zheng; Lu, Cui-Tao; Zhang, Yi; Xiao, Jian; Zhao, Ya-Ping; Tian, Ji-Lai; Xu, Yan-Yan;
Feng, Zhi-Guo; Xu, Chong-Yong
Onoue, Satomi; Aoki, Yosuke; Matsui, Takuya; Kojo, Yoshiki; Misaka, Shingen; Mizumoto,
Takahiro; Yamada, Shizuo
Li, DeXia; Guo, Gang; Fan, RangRang; Liang, Jian; Deng, Xin; Luo, Feng; Qian, ZhiYong
Nour, Samia A.; Abdelmalak, Nevine Shawky; Naguib, Marianne J
Gonzalez-Mira, Elisabet; Nikolić, Saša; Calpena, Ana C; Egea, M. Antonia; Souto, Eliana B;
García, M. Luisa
Gupta, S.; Siripurapu, K.; Ramya Swathi, M.; Kalluri, M.; Srinivasa Rao, M.; Kishore Kumar
Reddy, B.
Arun Kumar, T.; Velmurugan, S.; Ravishankar, K.; Nagarjuna Reddy, G.
Karbhari, P.A.; Joshi, S.J.; Bhoir, S.I.
Choudhary, P.; Aparna, C.; Srinivas, P.
Nagadevi, B.; Kumar, K.S.; Venkanna, P.; Prabhakar, D.

AÑOS DE REVISTA INDEXADA CATEGORIA-
2011 0.372
2013 1.059
0 2.933
2016 3.649
2009 3.649
2008 3.255
2016 2.302
2011 3.649
2013 2.981
2012 2.981
2011 2.936
2014 3.255
2013 2.933
2016 3.649
2013 3.653
2017 2.302
0 3.649
2017 3.649
2018 5.72
2014 6.369
2011 3.649
2008 3.649
2015 2.302
2016 3.756
2014 3.649
2010 3.649
2009 LIBRO
0 2.933
2014 7.786
2016 1.194
2008 3.255
2017 1.925
2016 6.369
2011 3.649
2008 4.159
2008 3.649
2017 3.653
2017 2.302
2012 3.649
2014 2.933
2013 1.194
2017 11.764
2016 3.526
2012 2.981
2010 0.421
2018 3.756
2014 1.194
2010 3.255
0 3.048
2011 2.302
2017 3.649
2014 3.255
2008 4.159
2010 2.981
2011 3.255
2018 3.756
2016 3.756
2013 3.649
2017 3.255
2011 3.255
2008 3.649
2014 2.108
2017 2.933
2013 3.649
2011 3.649
2013 3.649
2016 1.194
2012 2.933
2014 0.506
2014 1.96
2014 0.506
2014 0.163
2014 0.506
DOI DESCRAGADO
https://doi.org/10.1016/j.farma.2010.01.007 No
https://doi.org/10.1590/S0102-695X2012005000147 No
https://doi.org/10.1016/j.xphs.2017.09.012 No
https://doi.org/10.1016/j.ijpharm.2015.12.048 No
https://doi.org/10.1016/j.jpba.2008.02.030 No
https://doi.org/10.1016/j.jsps.2015.02.008 No
https://doi.org/10.1016/j.jep.2012.12.013 No
https://doi.org/10.1016/j.lfs.2011.06.026 No
https://doi.org/10.1002/jps.23650 No
https://doi.org/10.1016/j.ajps.2013.11.003 No
https://doi.org/10.1016/j.nano.2017.09.010 No
https://doi.org/10.1016/j.drudis.2014.08.006 No
https://doi.org/10.1016/j.ejps.2016.05.005 No
https://doi.org/10.1016/B978-0-444-53242-8.00021-7 No
https://doi.org/10.1016/j.xphs.2017.12.026 No
https://doi.org/10.1016/j.jconrel.2014.02.007 No
https://doi.org/10.1016/j.jddst.2016.04.010 No
https://doi.org/10.1016/j.jpha.2017.03.001 No
https://doi.org/10.1016/j.drudis.2016.04.024 No
https://doi.org/10.1016/j.ejpb.2007.12.003 No
https://doi.org/10.1016/j.ajps.2016.11.003 No
https://doi.org/10.1002/jps.24073 No
https://doi.org/10.1016/S1773-2247(13)50041-4 No
https://doi.org/10.1016/j.addr.2017.09.014 No
https://doi.org/10.1016/j.phymed.2016.05.005 No
https://doi.org/10.1016/S0975-3575(10)80021-5 No
https://doi.org/10.1016/j.ejps.2017.10.032 No
https://doi.org/10.1016/S1773-2247(14)50131-1 No
https://doi.org/10.1016/j.jfda.2017.02.006 No
https://doi.org/10.1016/j.ejpb.2008.06.009 No
https://doi.org/10.1016/j.jep.2009.11.010
https://doi.org/10.1016/j.jpba.2011.05.017 SI
https://doi.org/10.1016/j.ejps.2017.11.015
https://doi.org/10.1016/j.ejps.2015.12.018
https://doi.org/10.1016/j.ijpharm.2013.04.054
https://doi.org/10.1016/j.jpba.2017.01.037
https://doi.org/10.1016/j.jpba.2011.02.016
https://doi.org/10.1016/j.biomag.2014.07.007
https://doi.org/10.1016/j.xphs.2017.07.017
https://doi.org/10.1016/j.jddst.2016.06.001
https://doi.org/10.1002/jps.22784
84898404791&partnerID=40&md5=56c5ffac91d00b0f394c08e5cb3933a7
84907350068&partnerID=40&md5=9cc62d6adf491c03ebc82570be04606a
84896471557&partnerID=40&md5=8412ae556dbfa250aee232deec5f036e
84911366201&partnerID=40&md5=57b8567eb5b4a5b375098f1a27f4cd86
84899820127&partnerID=40&md5=6350f339306268ce14326293170536f9
No. REPOSARIO REVISTA
Eclética Química
1 REDALYC

Farmacéuticas
2 REDALYC

Farmacéuticas
3 REDALYC

Farmacéuticas
4 REDALYC
Journal of the Mexican Chemical Society

5 REDALYC

Farmacéuticas
6 REDALYC
Polímeros: Ciência e Tecnologia

7 REDALYC
Eclética Química
8 REDALYC

9 REDALYC

10 REDALYC

11 REDALYC
Vitae
12 REDALYC
VITAE
13 REDALYC
Farmacéuticas
14 REDALYC
Revista de la Sociedad Química del Perú

15 REDALYC
Revista CENIC. Ciencias Químicas

16 REDALYC
Eclética Química
17 REDALYC

Farmacéuticas
18 REDALYC
Vitae
19 REDALYC

Farmacéuticas
20 REDALYC
Eclética Química
21 REDALYC
Revista Boliviana de Química

22 REDALYC
Polímeros: Ciência e Tecnologia

23 REDALYC

24 REDALYC

Farmacéuticas
25 REDALYC

Farmacéuticas
26 REDALYC
Revista Cubana de Química

27 REDALYC
Farmacéuticas
28 REDALYC
Revista Cubana de Química

29 REDALYC

30 REDALYC
Vitae
31 REDALYC
Revista Colombiana de Química

32 REDALYC
Eclética Química
33 REDALYC

34 REDALYC

Farmacéuticas
35 REDALYC

Farmacéuticas
36 REDALYC
Avances en Química
37 REDALYC

Farmacéuticas
38 REDALYC
Vitae
39 REDALYC

40 REDALYC

41 REDALYC
42 REDALYC

Farmacéuticas
43 REDALYC
Università degli studi di Trieste

44 GOOGLE
ACADEMICO
Universidade Federal de Santa Catarina

GOOGLE
45
ACADEMICO
Journal of
GOOGLE Mazandaran University of Medical
46 Sciences
ACADEMICO
J.K.K. NATTRAJA COLLEGE OF

GOOGLE PHARMACY
47 KOMARAPALAYAM
ACADEMICO
Atmiya Institute of Pharmacy

48 GOOGLE
ACADEMICO
S.N.D.T. Women’s University, Mumbai

GOOGLE
49
ACADEMICO
Journal of Pharmaceutics & Drug

GOOGLE Development
50
ACADEMICO
International Journal of Pharmaceutical

GOOGLE Sciences and Nanotechnology
51 ACADEMICO
Journal of Innovations in Pharmaceuticals

GOOGLE and Biological Sciences
52
ACADEMICO
INTERNATIONAL JOURNAL OF
GOOGLE PHARMACEUTICAL SCIENCES AND
53 RESEARCH
ACADEMICO
INDO AMERICAN JOURNAL OF

GOOGLE PHARMACEUTICAL SCIENCES
54
ACADEMICO
Journal of Thermal Analysis and

GOOGLE Calorimetry
55
ACADEMICO
GOOGLE Research
56
ACADEMICO

GOOGLE Pharmaceutical Sciences
57
ACADEMICO
UNIVERSIDADE FEDERAL DO RIO

GRANDE DO SUL FACULDADE DE
58 LA REFERENCIA FARMÁCIA

Pharmacy
59 TAYLOR & FRANCIS

Pharmacy
60 TAYLOR & FRANCIS
Expert Opinion on Drug Delivery

61 TAYLOR & FRANCIS
The Physician and Sportsmedicine

62 TAYLOR & FRANCIS

Technology
63 TAYLOR & FRANCIS

Technology
64 TAYLOR & FRANCIS

Pharmacy
65 TAYLOR & FRANCIS

Technology
66 TAYLOR & FRANCIS

Pharmacy
67 TAYLOR & FRANCIS

68 SCOPUS

Pharmacy
69 SCOPUS
Pharmaceutics
70 SCOPUS
Fabad Journal of Pharmaceutical Sciences

71 SCOPUS

Technology
72 SCOPUS

73 SCOPUS
Advanced Pharmaceutical Bulletin

74 SCOPUS

Clinical Research
75 SCOPUS
Indian Journal of Pharmaceutical Sciences

76 SCOPUS

Clinical Research
77 SCOPUS
Latin American Journal of Pharmacy

78 SCOPUS

Pharmaceutics
79 SCOPUS
Developing Solid Oral Dosage Forms:

Pharmaceutical Theory and Practice:
80 SCOPUS Second Edition
AAPS PharmSciTech
81 SCOPUS
Journal of Young Pharmacists

82 SCOPUS
Journal of Pharmaceutical Sciences and

Research
83 SCOPUS
Journal of Pharmaceutical Investigation
84 SCOPUS

85 SCOPUS
Journal of Pharmaceutical Investigation

86 SCOPUS

Research
87 SCOPUS
Molecular Pharmaceutics
88 SCOPUS
Asian Journal of Pharmaceutics

89 SCOPUS

90 SCOPUS
Der Pharmacia Lettre

91 SCOPUS

Pharmacy
92 SCOPUS

93 SCOPUS

Research
94 SCOPUS
Indian Journal of Pharmaceutical Sciences

95 SCOPUS
Asian Journal of Pharmaceutics

96 SCOPUS

97 SCOPUS
Research
98 SCOPUS

Technology
99 SCOPUS

100 SCOPUS
Indian Drugs
101 SCOPUS
International Journal of Pharmaceutics

102 SCOPUS
Journal of Pharmaceutical and Biomedical

Analysis
103 SCOPUS

Clinical Research
104 SCOPUS

Pharmacy
105 SCOPUS

Research
106 SCOPUS

Research
107 SCOPUS

108 SCOPUS

109 SCOPUS
Pharma Research
110 SCOPUS

111 SCOPUS
Journal of Applied Pharmaceutical Science
112 SCOPUS
International Journal of Drug

Development and Research
113 SCOPUS
Revista de Ciencias Farmaceuticas Basica

e Aplicada
114 SCOPUS

115 SCOPUS

116 SCOPUS
International Journal of Pharmaceutical

Sciences Review and Research
117 SCOPUS

118 SCOPUS

Analysis
119 SCOPUS
Advanced Pharmaceutical Bulletin

120 SCOPUS

Technology
121 SCOPUS

Technology
122 SCOPUS

123 SCOPUS
American Pharmaceutical Review

124 SCOPUS

Technology
125 SCOPUS
126 SCOPUS

127 SCOPUS

128 SCOPUS

129 SCOPUS

130 SCOPUS

131 SCOPUS

Research
132 SCOPUS

133 SCOPUS
Journal of Pharmacy and Bioallied

Sciences
134 SCOPUS

Research
135 SCOPUS

Research
136 SCOPUS

Technology
137 SCOPUS

Clinical Research
138 SCOPUS

139 SCOPUS
140 SCOPUS

141 SCOPUS
Saudi Pharmaceutical Journal

142 SCOPUS
Journal of Chemical and Pharmaceutical

Sciences
143 SCOPUS
Journal of Pharmacy Research

144 SCOPUS

145 SCOPUS

146 SCOPUS

Technology
147 SCOPUS

Clinical Research
148 SCOPUS
Farmacia
149 SCOPUS
Pharmaceutical Research
150 SCOPUS
Indian Drugs
151 SCOPUS

Technology
152 SCOPUS
Farmacia
153 SCOPUS
Journal of Applied Pharmaceutical Science
154 SCOPUS

Technology
155 SCOPUS

Technology
156 SCOPUS

157 SCOPUS

Technology
158 SCOPUS
Acta Pharmaceutica
159 SCOPUS
Pharma Research
160 SCOPUS
Journal of Global Pharma Technology

161 SCOPUS
Chemical and Pharmaceutical Bulletin

162 SCOPUS

Clinical Research
163 SCOPUS
International Journal of Pharmacology

164 SCOPUS

Technology
165 SCOPUS
AAPS PharmSciTech
166 SCOPUS
AAPS PharmSciTech
167 SCOPUS
pharmacy
168 PUBMED

biotechnology
169 PUBMED
Journal of pharmaceutical innovation

170 PUBMED
Pharmaceutical nanotechnology
171 PUBMED
AAPS PharmSciTech
172 PUBMED
International journal of molecular

sciences
173 PUBMED
Advances in colloid and interface science

174 PUBMED

pharmacy
175 PUBMED

macromolecules
176 PUBMED

177 PUBMED
Journal of pharmaceutical sciences

178 PUBMED
Advanced pharmaceutical bulletin

179 PUBMED
Journal of pharmaceutical and biomedical

analysis
180 PUBMED

investigation
181 PUBMED
Applied biochemistry and biotechnology
182 PUBMED
International journal of pharmaceutics

183 PUBMED

184 PUBMED

185 PUBMED
Journal of nanobiotechnology
186 PUBMED

investigation
187 PUBMED

analysis
188 PUBMED

189 PUBMED
Journal of pharmaceutics
190 PUBMED

191 PUBMED

technology
192 PUBMED
Acta chimica Slovenica

193 PUBMED

technology
194 PUBMED
AAPS PharmSciTech
195 PUBMED
AAPS PharmSciTech
196 PUBMED

technology
197 PUBMED
The Journal of pharmacy and

pharmacology
198 PUBMED
AAPS PharmSciTech
199 PUBMED

analysis
200 PUBMED
Blood
201 PUBMED
Pharmaceutics
202 PUBMED
Journal of drug targeting

203 PUBMED

macromolecules
204 PUBMED

investigation
205 PUBMED
International journal of nanomedicine

206 PUBMED
BioMed research international

207 PUBMED
Journal of drug delivery

208 PUBMED
Current drug delivery

209 PUBMED
Planta medica
210 PUBMED
AAPS PharmSciTech
211 PUBMED
Iranian journal of pharmaceutical research

: IJPR
212 PUBMED
AAPS PharmSciTech
213 PUBMED
Zhongguo Zhong yao za zhi = Zhongguo

zhongyao zazhi = China journal of Chinese
214 PUBMED materia medica

215 PUBMED
Journal of drug delivery

216 PUBMED
Planta medica
217 PUBMED
TheScientificWorldJournal
218 PUBMED

219 PUBMED
Indian journal of pharmaceutical sciences

220 PUBMED
Current vascular pharmacology

221 PUBMED
BioMed research international

222 PUBMED
Drug delivery
223 PUBMED
Drug delivery
224 PUBMED
Journal of biomedical nanotechnology

225 PUBMED

investigation
226 PUBMED
Journal of pharmaceutics
227 PUBMED

official publication of the Saudi
228 PUBMED Pharmaceutical Society
Journal of pharmacy & bioallied sciences

229 PUBMED

230 PUBMED
Drug discoveries & therapeutics

231 PUBMED
Journal of ethnopharmacology
232 PUBMED

233 PUBMED

technology
234 PUBMED

235 PUBMED

236 PUBMED
AAPS PharmSciTech
237 PUBMED
European journal of pharmaceutical
sciences : official journal of the European
238 PUBMED Federation for Pharmaceutical Sciences

pharmacy
239 PUBMED

biotechnology
240 PUBMED

241 PUBMED Arbeitsgemeinschaft fur Pharmazeutische
Verfahrenstechnik e.V
technology
242 PUBMED
Journal of cosmetic science

243 PUBMED
Journal of AOAC International

244 PUBMED
Journal of young pharmacists

245 PUBMED

246 PUBMED

pharmacy
247 PUBMED
AAPS PharmSciTech
248 PUBMED

macromolecules
249 PUBMED
Supportive care in cancer : official journal

of the Multinational Association of
250 PUBMED Supportive Care in Cancer
The Cochrane database of systematic

reviews
251 PUBMED
analysis
252 PUBMED
Acta poloniae pharmaceutica

253 PUBMED
AAPS PharmSciTech
254 PUBMED
European review for medical and

pharmacological sciences
255 PUBMED

256 PUBMED
Analytica chimica acta

257 PUBMED
Medical science monitor : international

medical journal of experimental and
258 PUBMED clinical research
Journal of the mechanical behavior of

biomedical materials
259 PUBMED

260 PUBMED

macromolecules
261 PUBMED
Colloids and surfaces. B, Biointerfaces

262 PUBMED
Anesthesia and analgesia

263 PUBMED

264 PUBMED
American journal of health-system

pharmacy
265 PUBMED
266 PUBMED
Postgraduate medicine
267 PUBMED

Journal of ethnopharmacology
269 PUBMED

Journal of materials science. Materials in

medicine
271 PUBMED
Analytical and bioanalytical chemistry

272 PUBMED
AAPS PharmSciTech
273 PUBMED

274 PUBMED

Planta medica
276 PUBMED
Journal of palliative medicine

277 PUBMED
European journal of anaesthesiology

278 PUBMED

technology
279 PUBMED
pharmacy
280 PUBMED

pharmacy
281 PUBMED
Journal of analytical toxicology

282 PUBMED

283 PUBMED

pharmacy
284 PUBMED
Spectrochimica acta. Part A, Molecular

and biomolecular spectroscopy
285 PUBMED
Journal of clinical and diagnostic

research : JCDR
286 PUBMED
AAPS PharmSciTech
287 PUBMED
Bioconjugate chemistry
288 PUBMED

macromolecules
289 PUBMED

AAPS PharmSciTech
291 PUBMED

292 PUBMED

biotechnology
293 PUBMED
Expert opinion on drug delivery
294 PUBMED

295 PUBMED

AAPS PharmSciTech
297 PUBMED
Colloids and surfaces. B, Biointerfaces

298 PUBMED
Drug design, development and therapy

299 PUBMED

pharmacy
300 PUBMED
AAPS PharmSciTech
301 PUBMED
Drug design, development and therapy

302 PUBMED

technology
303 PUBMED

pharmacy
304 PUBMED

PDA journal of pharmaceutical science

and technology
306 PUBMED

307 PUBMED
308 PUBMED

309 PUBMED

technology
310 PUBMED
Journal of biomaterials applications

311 PUBMED

312 PUBMED
Pharmacognosy research
313 PUBMED

technology
314 PUBMED

technology
315 PUBMED
Die Pharmazie
316 PUBMED
Chemical & pharmaceutical bulletin

317 PUBMED

318 PUBMED Arbeitsgemeinschaft fur Pharmazeutische
Verfahrenstechnik e.V
Sciences
319 SCIELO

Sciences
320 SCIELO
Química Nova
321 SCIELO
Revista Cubana de Farmacia
322 SCIELO

323 SCIELO

324 SCIELO
Revista Brasileira de Ciências

Farmacêuticas
325 SCIELO
Revista de la Sociedad Española del Dolor

326 SCIELO
Revista da Sociedade Brasileira de

Medicina Tropical
327 SCIELO
Farmacia Hospitalaria
328 SCIENCEDIRECT
Revista Brasileira de Farmacognosia

329 SCIENCEDIRECT

330 SCIENCEDIRECT

331 SCIENCEDIRECT

332 SCIENCEDIRECT

Analysis
333 SCIENCEDIRECT

334 SCIENCEDIRECT

335 SCIENCEDIRECT
Journal of Ethnopharmacology
336 SCIENCEDIRECT
337 SCIENCEDIRECT
Life Sciences
338 SCIENCEDIRECT

Analysis
339 SCIENCEDIRECT

340 SCIENCEDIRECT

341 SCIENCEDIRECT
Asian Journal of Pharmaceutical Sciences

342 SCIENCEDIRECT

343 SCIENCEDIRECT

344 SCIENCEDIRECT

345 SCIENCEDIRECT
Nanomedicine: Nanotechnology, Biology

and Medicine
346 SCIENCEDIRECT
Drug Discovery Today

347 SCIENCEDIRECT

348 SCIENCEDIRECT

349 SCIENCEDIRECT
350 SCIENCEDIRECT

Sciences
351 SCIENCEDIRECT

352 SCIENCEDIRECT

353 SCIENCEDIRECT
Academic Press
354 SCIENCEDIRECT

355 SCIENCEDIRECT
Journal of Controlled Release

356 SCIENCEDIRECT

Technology
357 SCIENCEDIRECT

Analysis
358 SCIENCEDIRECT
Journal of Pharmaceutical Analysis

359 SCIENCEDIRECT
Drug Discovery Today

360 SCIENCEDIRECT

361 SCIENCEDIRECT
European Journal of Pharmaceutics and

Biopharmaceutics
362 SCIENCEDIRECT

363 SCIENCEDIRECT
Asian Journal of Pharmaceutical Sciences
364 SCIENCEDIRECT

365 SCIENCEDIRECT

366 SCIENCEDIRECT

367 SCIENCEDIRECT

Technology
368 SCIENCEDIRECT
Advanced Drug Delivery Reviews

369 SCIENCEDIRECT
Phytomedicine
370 SCIENCEDIRECT
371 SCIENCEDIRECT
Pharmacognosy Journal
372 SCIENCEDIRECT

Sciences
373 SCIENCEDIRECT

Technology
374 SCIENCEDIRECT

Analysis
375 SCIENCEDIRECT
Journal of Food and Drug Analysis

376 SCIENCEDIRECT

377 SCIENCEDIRECT
378 SCIENCEDIRECT

Analysis
379 SCIENCEDIRECT
European Journal of Pharmaceutics and

Biopharmaceutics
380 SCIENCEDIRECT
381 SCIENCEDIRECT

Analysis
382 SCIENCEDIRECT

Sciences
383 SCIENCEDIRECT

Sciences
384 SCIENCEDIRECT

385 SCIENCEDIRECT

Analysis
386 SCIENCEDIRECT

Analysis
387 SCIENCEDIRECT

388 SCIENCEDIRECT
Biomedicine & Aging Pathology

389 SCIENCEDIRECT

390 SCIENCEDIRECT

391 SCIENCEDIRECT
392 SCIENCEDIRECT

393 SCIENCEDIRECT

Technology
394 SCIENCEDIRECT

395 SCIENCEDIRECT

396 SCIENCEDIRECT

397 SCIENCEDIRECT

398 SCIENCEDIRECT

Technology
399 SCIENCEDIRECT

400 SCIENCEDIRECT
AUTOR (ES)
TITULO
A novel indicator reaction for the catalytic determination of V(V) at ppb levels by the kinetic
spectrophotometric method
Almidón retrogradado para uso en compresión directa. I. Caracterización y egelatinización del

almidón de chayote
Almidón retrogradado para uso en compresión directa. II. Compactación de almidón de

chayote retrogradado
Análisis isobolográfico de la combinación analgésica ketorolaco sistémico y tramadol local en el

modelo de la formalina en ratones
Antibacterial Activity of Pipemidic Acid ions-MgFeAl Layered Double

Hydroxide Hybrid Against E. coli and S. typhi
Anti-inflammatory activity of aqueous and methanolic extracts of Oenothera rosea L' Hér. ex
Ait in the rat
Aplicações Farmacêuticas de Polímeros
Argentimetric assay of ranitidine in bulk drug and in dosage forms
Biosíntesis de los alcaloides indólicos. Una revisión crítica
Caracterización física de hidroxipropilmetilcelulosa con potencial aplicación oftalmológica: pH,

tensión superficial, característica de la película
Caracterización reológica de hidroxipropilmetilcelulosa con potencial aplicación oftalmológica
CHEMICAL COMPOSITION AND ANTI-IRRITANT CAPACITY OF WHOLE BODY EXTRACTS OF

Ulomoides dermestoides (COLEOPTERA, TENEBRIONIDAE)
COLOMBIAN BIODIVERSITY, AN OPPORTUNITY FOR THE STRENGTHENING OF THE

PHARMACEUTICAL AND COSMETIC INDUSTRIES
Compactabilidad como un parámetro de funcionalidad del excipiente GalenIQ 720
COMPARACIÓN DE LA ACCIÓN ANTIINFLAMATORIA Y ANALGÉSICA DEL POLVO

DE Salpichroa origanifolia CON AINES UTILIZADOS EN MEDICINA VETERINARIA
Conductimetric study of the interpolyelectrolyte reaction between chitosan and pectin
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE

DETERMINATION OF DPP-4 INHIBITOR, SITAGLIPTIN, IN ITS PHARMACEUTICAL
PREPARATIONS
Ecofarmacovigilancia en México: perspectivas para su implementación
EFECTO DE ALGUNOS SOLVENTES ORGÁNICOS EN SATURACIÓN SOBRE LAS FUNCIONES

TERMODINÁMICAS DE DISOLUCIÓN DEL NAPROXÉN EN MEDIOS ACUOSOS A pH FISIOLÓGICO
Efecto del bicarbonato de sodio sobre la flotación y la liberación controlada de metronidazol

desde matrices de Methocel K4M y Carbopol 971P NF
Efeito da complexação de metais aos antiinflamatórios na ação contra agentes oxidativos e

radicais livres: ação do cetoprofeno
EFFECT IN ACUTE INFLAMMATION OF SAPOGENIN EXTRACT ANDISOLATED SAPOGENINS

FROM QUINOA WASTE (CHENOPODIUM QUINOA WILLD)
Effect of Crosslinking Agents on Chitosan Microspheres in Controlled Release of Diclofenac

Sodium
Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric
acid matrix tablets
El aceite de pescado protege contra el daño gástrico generado por la administración de

indometacina y adiciona su actividad anti-inflamatoria a la indometacina en la rata
El uso de las microondas en la industria farmacéutica
ESTUDIO DE LA CORROSIÓN DE LA TORRE DE DESTILACIÓN ATMOSFÉRICA DE LA REFINERÍA

“HERMANOS DÍAZ” DE SANTIAGO DE CUBA
Estudios preliminares sobre el efecto analgésico del extracto de hojas de Ageratina glabrata en
dos modelos térmicos de dolor agudo
EVALUACIÓN DE LA ESTABILIDAD DE UNA EMULSIÓN OLEOSA DE CÉLULAS INACTIVAS DE

MYCOPLASMA GALLISEPTICUM
Evaluación tecnológica del polvo de la planta Parthenium hysterophorus L. con un propósito

farmacéutico
EVALUATION OF PHARMACOTHERAPY USED ON GERIATRIC POPULATION IN AN INSTITUTION

OF SPECIAL REGIME WITH THE SCREENING TOOL OF OLDER PERSONS’ POTENTIALLY
INAPPROPRIATE PRESCRIPTIONS (STOPP) CRITERIA
Extended Hildebrand solubility approach applied to some structurally related sulfonamides in

ethanol + water mixtures
Flow injection analysis of vancomycin
Identificación y caracterización in silico de la zona de interación entre el péptido beta-amiloide

y compuestos derivados del naftaleno
Impacto del recubrimiento estético sobre la liberación de tabletas osmóticas

bicompartimentales de Nifedipino
Influence of different types of lactose on tablets compactibility
Las furan-2[5H]-onas (Da,B-butenolidas), su preparación e importancia biológica
Los excipientes y su funcionalidad en productos farmacéuticos sólidos
PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME

POLYELECTROLYTEDICLOFENAC COMPLEXES
Síntesis de nuevos derivados del naftaleno
Synthesis of potential anti-inflammatory compounds, selective inhibitors of cyclooxygenase-2

(COX-2)
Theoretical Study of Isoindolines to Identify them as Cyclooxygenase-1 and -2 Inhibitors by
Docking Simulations
Tratamientos farmacológicos contra alternativos en el manejo de pacientes con artritis

reumatoide
Preparazione e caratterizzazione di forme farmaceutiche solide orali a partire da materiale

composito
Avaliação de complexos de sílica mesoporosa (SBA-15) com fármacos (Naproxeno e

Estavudina)
Evaluation of solid-state physical stability and compatibility of piroxicam with tablet excipients
by physicochemical methods
Formulation and Evaluation of Lansoprazole Enteric Coated Pellets.
Formulation and Characterization of Bilayer Tablet of Dicyclomine hydrochloride and

Mefenamic acid for Colon Targeted Drug Delivery
Developmant of oral controlled drug delivery systems for pain management
Croscarmellose Sodium Efficiency in the Development of a Generic Capsule

Formulation of Piroxicam, Comparable Dissolution Profile to the Innovator
Product, Feldene
Preparation and In vivo Evaluation of Mucoadhesive Microspheres for Gastroretentive Delivery

of Misoprostol
Nanocarrier based transdermal formulation of NSAID: Optimization of

drug loading and analysis of permeation characteristics
FORMULATION AND EVALUATION OF NAPROXEN AND PANTOPRAZOLE MULTILAYERED

TABLETS
DESIGN, DEVELOPMENT AND EVALUATION OF NOVEL

ORAL MEDICATED JELLIES
Compatibility study of the acetylsalicylic acid with different solid dosage forms excipients
Formulation Development and Evaluation of Floating Microspheres Of Gemifloxacin Mesylate
Studies on the investigation of ¬preformulation parameters, compatibility studies to design

and formulate the etodolac solid dispersions
Aplicação de métodos termo-analíticos e espectroscópicos na avaliação do

comportamento do fármaco isoniazida frente a adjuvantes
Compatibility Studies Between Ibuprofen or Ketoprofen

with Cellulose Ether Polymer Mixtures Using Thermal
Analysis
Multiparticulate Drug Delivery System of Aceclofenac:

Development and In Vitro Studies
Nanoparticles in drug delivery: mechanism of action,

formulation and clinical application towards reduction in
drug-associated nephrotoxicity
Dimethyl Sulfoxide: An Effective Penetration Enhancer for Topical Administration of NSAIDs
Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam
Design and in vitro evaluation of novel sustained-release matrix tablets for lornoxicam based
on the combination of hydrophilic matrix formers and basic pH-modifiers
In vitro release of ketoprofen from hydrophilic matrix tablets containing cellulose polymer
mixtures
Preparation and in vitro characterization of piroxicam enteric coated pellets using powder
layering technique
Compatibility Study Between Ketoprofen and Tablet Excipients Using Differential Scanning
Calorimetry
Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired
Gastric Motility
Stability of pharmaceutical salts in solid oral dosage forms

Development, characterization and evaluation of soft oral edible gel using gellan gum
Formulation and evaluation of baclofen mucoadhesive buccal films
Design, development and optimization of pulsatile core in cup tablets of naproxen
The influence of excipients on physical and pharmaceutical properties of oral lyophilisates

containing a pregabalin-acetaminophen combination
Thermal stability and kinetic study of fluvoxamine stability in binary samples with lactose
Effect of effervescence in combination with superdisintegrants in the formulation of

propranolol hcl oral disintegrating tablets
Design and pharmacodynamic evaluation of optimized microporous osmotic tablets of

venlafaxine hydrochloride
Formulation development, characterization, and in vitro evaluation of floating matrix dosage

form of tramadol hydrochloride using various polymers
Compatibility studies of entacapone with carbidopa, L-dopa, and pharmaceutical excipients for
a fixed dose combination product
Preparation, characterization and evaluation of floating microparticles of ciprofloxacin
Excipient compatibility and functionality
QbD-Oriented Development and Characterization of Effervescent Floating-Bioadhesive Tablets

of Cefuroxime Axetil
Development and characterization of thermosensitive intranasal gel containing paliperidone

loaded microspheres
Controlled - Release effervescent floating tablet of verapamil hydrochloride: Development and

opitmization
Quality by design approach for development and optimization of Quetiapine Fumarate
effervescent floating matrix tablets for improved oral bioavailability
Development of extended release matrix tablets of felodipine through solid dispersions for
better drug release profile by a 32factorial design
Brain targeting efficiency of Curcumin loaded mucoadhesive microemulsion through intranasal

route
Identification of pharmaceutical excipient behavior of chickpea (Cicer arietinum) starch in

gliclazide immediate release tablets
Acid-Base Interactions of Polystyrene Sulfonic Acid in Amorphous Solid Dispersions Using a

Combined UV/FTIR/XPS/ssNMR Study
Drug-excipient interaction study for apple cider vinegar with 20 potential excipients using
modern analytical techniques
Selection of excipients for galantamine hbr orodispersible tablet through drug excipient
compatibility study
Design and evaluation of sodium alginate microspheres loaded with Gatifloxacin
Development, optimization and in vivo characterization of domperidone-controlled release

hot-melt-extruded films for buccal delivery
Glimepiride fast disintegrating tablets: Formulation, evaluation and in vivo disintegration and
dynamic studies
Investigation of blends of cashew and xanthan gums as a potential carrier for colonic delivery
of Ibuprofen
Preparation and characterization of PEG-albumin-curcumin nanoparticles intended to treat

breast cancer
Formulation and evaluation of chlorhexidine medicated chewing gums by different methods
In vitro drug analysis and stability studies of optimized formulations of aceclofenac (100 mg)
tablets
Effect of polymer and plasticizer on thin polymeric buccal films of meloxicam designed by
using central composite rotatable design
Combined dosage form of pioglitazone and felodipine as mucoadhesive pellets via hot melt
extrusion for improved buccal delivery with application of quality by design approach
Formulation and evaluation of levamisole oral dispersible tablets
Improvement of dissolution rate of febuxostat using hybrid technique of spherical

crystallization and solid dispersion
Evaluation of microwave oven heating for prediction of drug-excipient compatibilities and

accelerated stability studies
Structure elucidation and quantification of impurities formed between 6-aminocaproic acid

and the excipients citric acid and sorbitol in an oral solution using high-resolution mass
spectrometry and nuclear magnetic resonance spectroscopy
Design and evaluation of torsemide controlled release matrix tablets
The stress stability of olanzapine: Studies of interactions with excipients in solid state
pharmaceutical formulations
Selection of excipients for the formulation of ceftriaxone sodium loaded chitosan nanoparticle
through drug-excipient compatibility testing
Selection of excipients for memantine hydrochloride nanoparticles through drug excipient

Selection of excipients for the formulation of Ceftriaxone sodium loaded chitosan Nanoparticle
through drug - Excipient compatibility testing
Formulation design and invitro evaluation of oral disintegrating tablets of Carbidopa and
Levodopa
Formulation and optimization of ocular films of ofloxacin and ketorolac tromethamine
Formulation and evaluation of pioglitazone hydrochloride pellets

Formulation, in vitro characterization and stability studies of fast dispersing tablets of
diclofenac sodium
Formulation and in vitro evaluation of sustained release floating matrix tablet of Rosiglitazone
Maleate
Solid-state characterization and pharmaceutical compatibility of ziprasidone hydrochloride
Formulation and optimization of olanzapine sustained release matrix tablets for the treatment
of schizophrenia
Diclofenac sodium pellets for flexible pediatric drug dosing: Preparation, characterization and
evaluation
Preparation and evaluation of sustained release matrix tablets of bosentan by using wet
granulation technique
Selection of excipients for polymer coated capsule of celecoxib through drug-excipient

Drug-excipient compatibility screening-Role of thermoanalytical and spectroscopic techniques
Drug-drug/drug-excipient compatibility studies on curcumin using non-thermal methods
Compatibility studies of quercetin with pharmaceutical excipients used in the development of

novel formulation
Advances in analytical techniques used in predicting drug-excipient interactions
Drug-excipients compatibility studies of Nicorandil in controlled release floating tablet
Investigation of excipient compatibility and associated degradations for the formulation

development of a small molecule pharmaceutical compound
Formulation and evaluation of bilayer tablet of metformin HCl and pioglitazone HCl
Formulation and evaluation of mucoadhesive vaginal tablets of tenofovir disoproxil fumarate
Formulation development and evaluation of fast disintegrating tablets of Ambroxol

hydrochloride for pediatrics- a novel approach for drug delivery
Kinetics of the esterification of active pharmaceutical ingredients containing carboxylic acid

functionality in polyethylene glycol: Formulation implications
Formulation and evaluation of modified pulsincap drug delivery system of rizatriptan benzoate
Application of modified USP apparatus I and in situ fiber optic analysis for drug release from
ibuprofen nanospheres
Preparation and characterization of ethyl cellulose microspheres encapsulating metformin

hydrochloride and glipizide
Formulation, characterisation and evaluation of sustained release microcapsules of

gemifloxacin
In-situ injectable thermosensitive gel based on poloxamer as a new carrier for Tamoxifen
citrate
Design and development of cefdinir niosomes for oral delivery
Application of differential scanning calorimetry in evaluation of solid state interactionsin

tablets containing acetaminophen
Effect of two hydrophobic polymers on the release of gliclazide from their matrix tablets
Formulation and evaluation of Nizatidine floating tablets by using natural, semisynthetic and
synthetic polymers
Formulation and evaluation of bilayermatrix tablet of Pioglitazone HCL Metformin HCL USP
15MG&500MG
Study on crystallinity and compactibility of binary mixture of analgesic substances with

Microcrystalline cellulose
Selection of excipients for nanoparticles formulations of Nateglinide through drug-excipients
compatibility study
Formulation development and evaluation of lamivudine controlled release tablets using cross-
linked sago starch
characterization
Formulation of Venlafaxine Sustained Release capsule dosage form
Formulation design and optimization of novel mouth dissolving tablets for venlafaxine
hydrochloride using sublimation technique
Formulation and evaluation of sitagliptin phosphate and metformin hydrochloride trilayered

tablets
Fabrication and evaluation of Domperidone transdermal films
Formulation and evaluation of Bi-Layered matrix tablets of Metformin and Pioglitazone for
Biphasic Drug Release
Design, development and evaluation of floating tablets of tapentadol hydrochloride using

Chitosan
Design of double layer tablets of valethamate bromide by using various polymers by direct
compression method
Impact of excipient interactions on solid dosage form stability
Compatibility studies of acetazolamide with excipients by using high performance liquid

chromatography (HPLC) technique
Formulation and In-Vitro evaluation of Aceclofenac Controlled release tablets by wet

granulation method and solid dispersion technique
Compatibility studies of indapamide/pharmaceutical excipients used in tablet preformulation

Formulation and evaluation of gastroretentive floating tablets of domperidone maleate
Formulation and optimization of tenoxicam orodispersible tablets by solid deposition

technique
Compatibility study of Aceclofenac and tablet disintegrants by thermal and nonthermal

methods
Compatibility studies of olanzapine pre-formulated with excipients by thermal analysis:

Preliminary study
Compatibility study of gatifloxacin with various excipients
Compatibility studies of nateglinide with excipients in immediate release tablets
Design, development and In vitro evaluation of floating tablets of atenolol
Preparation and evaluation of tramadol hydrochloride microspheres by coacervation phase

separation technique using various solvents and non-solvents
Design of meloxicam and lornoxicam transdermal patches: Preparation, physical

characterization, ex vivo and in vivo studies
A study on the effect of different cellulose polymers on release rate from tramadol loaded
microspheres prepared by emulsion solvent evaporation method
Studies of in vitro evaluation and formulation of aceclofenac loaded PLGA microspheres
Understanding drug-excipient compatibility: Oxidation of compound A in a solid dosage form

Understanding drug-excipient compatibility
Hydroxypropyl Methylcellulose Acetate Succinate: Potential Drug - Excipient Incompatibility
Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: In
Vitro and In Vivo studies
Upgrading of dissolution and anti-hypertensive effect of Carvedilol via two combined
approaches: self-emulsification and liquisolid techniques
Fabrication of Niclosamide loaded solid lipid nanoparticles: in vitro characterization and

comparative in vivo evaluation.
Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC
for HIV prevention
A self- nanoemulsifying drug delivery system for poorly water soluble tolbutamide:
development, optimization and pharmacodynamic studies.
Commentary: Why Pharmaceutical Scientists in Early Drug Discovery Are Critical for Influencing
the Design and Selection of Optimal Drug Candidates
Comparative Solid-State Stability of Perindopril Active Substance vs. Pharmaceutical

Formulation
Adsorption of poly(ethylene oxide)-containing amphiphilic polymers on solid-liquid interfaces:

Fundamentals and applications.
Solid effervescent formulations as new approach for topical minoxidil delivery.
Radiation formation of functionalized polysaccharide-protein based skin mimicking semi- inter

penetrating network for biomedical application
Evaluation of in-vitro cytotoxicity and cellular uptake efficiency of zidovudine-loaded solid lipid
nanoparticles modified with Aloe Vera in glioma cells
Dehydration and Stabilization of a Reactive Tertiary Hydroxyl Group in Solid Oral Dosage Forms
of BMS-779788
Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and

ex vivo Evaluation
Solid state compatibility study and characterization of a novel degradation product of

tacrolimus in formulation
Formulation Development and evaluation of fast disintegrating tablets of Lamotrigine using

liqui-solid technique
Detergent-compatible bacterial amylases
In vivo evaluation and in-depth pharmaceutical characterization of a rapidly dissolving solid

ocular matrix for the topical delivery of timolol maleate in the rabbit eye model
Development of protocol for screening the formulation components and the assessment of
common quality problems of nano-structured lipid carriers
Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse
transcriptase inhibitor
Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of

curcumin
Development and evaluation of a novel biodegradable sustained release microsphere

formulation of paclitaxel intended to treat breast cancer
Drug-excipient compatibility screening--role of thermoanalytical and spectroscopic techniques
Long chain lipid based tamoxifen NLC. Part I: preformulation studies, formulation
development and physicochemical characterization
Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles

to Improve the Oral Bioavailability
Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier

sucrose fatty acid ester.
Solid-state compatibility screening of excipients suitable for development of indapamide

sustained release solid-dosage formulation
Using different experimental designs in drug-excipient compatibility studies during the

preformulation development of a stable solid dosage formulation
Evaluation of hypericin-loaded solid lipid nanoparticles: physicochemical properties,

photostability and phototoxicity
A preformulation study of a new medicine for Chagas disease treatment: physicochemical

characterization, thermal stability, and compatibility of benznidazole
Stability of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in combination.
Understanding drug-excipient compatibility: oxidation of compound A in a solid dosage form.
Compatibility of chewing gum excipients with the amino acid L-cysteine and stability of the
active substance in directly compressed chewing gum formulation
Optimization studies on design and evaluation of orodispersible pediatric formulation of

indomethacin
Compatibility studies between mannitol and omeprazole sodium isomers
CD38 antibodies in multiple myeloma: back to the future
Development and Validation of an UPLC-MS/MS Method for Pharmacokinetic Comparison of

Five Alkaloids from JinQi Jiangtang Tablets and Its Monarch Drug Coptidis Rhizoma
Translation of Combination Nanodrugs into Nanomedicines: Lessons Learned and Future

Outlook
Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and

in vitro and in vivo evaluations
Formulation development and evaluation of zolmitriptan oral soluble films using 2(2) factorial
designs
Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of

terconazole: development, in vitro and in vivo studies
Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity and In Vivo
Evaluation
Development of Oral Dissolvable Films of Diclofenac Sodium for Osteoarthritis Using Albizia
and Khaya Gums as Hydrophilic Film Formers
Development and Optimization of Dual Drugs (Isoniazid and Moxiflox-acin) Loaded Functional
PLGA Nanoparticles for the Synergistic Treatment of Tuberculosi
Development of Bilayer Tablets with Modified Release of Selected Incompatible Drugs
Development and Evaluation of Biodegradable Chitosan Films of Metronidazole and

Levofloxacin for the Management of Periodontitis
Design and Comparative Evaluation of In-vitro Drug Release, Pharmacokinetics and Gamma
Scintigraphic Analysis of Controlled Release Tablets Using Novel pH Sensitive Starch and
Modified Starch-acrylate Graft Copolymer Matrices
QbD-Enabled Development of Novel Stimuli-Responsive Gastroretentive Systems of Acyclovir

for Improved Patient Compliance and Biopharmaceutical Performanc
Advance in modern studies on compatibility of Coptidis Rhizoma and Evodiae Fructus
Development of subcutaneous sustained release nanoparticles encapsulating low molecular

weight heparin
Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate,

cetirizine hydrochloride in combined pharmaceutical dosage form: a new era in novel drug
delivery for pediatrics and geriatrics
Prospects of boswellic acids as potential pharmaceutics
Gastroretentive pulsatile release tablets of lercanidipine HCl: development, statistical

optimization, and in vitro and in vivo evaluation
Novel in situ gelling ocular films for the opioid growth factor-receptor antagonist-naltrexone
hydrochloride: fabrication, mechanical properties, mucoadhesion, tolerability and stability
studies
Development and Evaluation of Melt-in-Mouth Tablets of Metoclopramide Hydrochloride

Using Novel Co-processed Superdisintegrants
Recent Pharmacokinetic Studies in Combination Therapies for Diabetes and Related Vascular
Complications
Development and characterization of in situ oral gel of spiramycin
QbD-enabled systematic development of gastroretentive multiple-unit microballoons of

itopride hydrochloride
Effect of polydimethylsiloxane and ethylcellulose on in vitro permeation of centchroman from
its transdermal patches
Development and characterization of pilocarpine loaded Eudragit nanosuspensions for ocular

drug delivery
Development and evaluation of chitosan based oral controlled matrix tablets of losartan
potassium
Development of Orodispersible Tablets of Candesartan Cilexetil- β -cyclodextrin Complex
Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline:

development, characterization, and performance evaluation
Development and characterisation of thermo reversible mucoadhesive moxifloxacin

hydrochloride in situ ophthalmic gel
Development of Orodispersible Tizanidine HCl Tablets Using Spray Dried Coprocessed Exipient
Bases
Development and characterization of local anti-inflammatory implantation for the controlled

release of the hexane extract of the flower-heads of Euryops pectinatus L. (Cass.
Kinetics of aristolochic acid I after oral administration of Radix Aristolochiae or Guanxinsuhe

preparation in canines
Improved bioavailability through floating microspheres of lovastatin
Design and optimization of a stomach-specific drug delivery system of repaglinide: application

of simplex lattice design
Design and development of hydrogel nanoparticles for mercaptopurine
Topical formulations of serratiopeptidase: development and pharmacodynamic evaluation
Multiunit floating drug delivery system of rosiglitazone maleate: development,

characterization, statistical optimization of drug release and in vivo evaluation
Preformulation studies of ceftriaxone for pediatric non-parenteral administration as an
alternative to existing injectable formulations
Preparation of benznidazole pellets for immediate drug delivery using the extrusion
spheronization technique
Preliminary studies for the development of intranasal nanoemulsion containing CNS agent:
emphasizing the utilization of cut and weigh method
Preformulation studies and optimization of sodium alginate based floating drug delivery
system for eradication of Helicobacter pylori
Physicochemical characterization of native glycyl-l-histidyl-l-lysine tripeptide for wound healing

and anti-aging: a preformulation study for dermal delivery
Drug-excipient compatibility studies in binary mixtures of avobenzone
Application of chemometrically processed thermogravimetric data for identification of

baclofen-excipient interactions
Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy

Propyl Methyl Cellulose as Rate-controlling Polymer
Clotrimazole nanoemulsion for malaria chemotherapy. Part I: preformulation studies,

formulation design and physicochemical evaluation
Development and evaluation of a pH-dependent sustained release tablet for irritable bowel
syndrome
Preformulation considerations for controlled release dosage forms. Part II. Selected candidate
support
Effect of crosslinker on drug delivery properties of curcumin loaded starch coated iron oxide
nanoparticles
Multidrug infusions in a Swiss palliative care unit: assessment of frequent combinations in

terms of clinical effectiveness, compatibility, and stability
Oral non-steroidal anti-inflammatory drugs (single dose) for perineal pain in the early
postpartum period
Microdialysis combined with UPLC-MS/MS method for determination of tetramethylpyrazine
and ferulic acid in striatum of awake and anesthetic rats subjected to cerebral ischemia
STUDYING THE IMPACT OF FORMULATION AND PROCESSING PARAMETERS ON THE RELEASE

CHARACTERISTICS FROM HYDROXYPROPYL METHYLCELLULOSE MATRIX TABLETS OF
DICLOFENAC
Sustained Anti-inflammatory Effect of Resveratrol-Phospholipid Complex Embedded Polymeric

Patch
Anti-inflammatory effects exerted by Killox®, an innovative formulation of food supplement

with curcumin, in urology
New Thermoresponsive Eyedrop Formulation Containing Ibuprofen Loaded-Nanostructured

Lipid Carriers (NLC): Development, Characterization and Biocompatibility Studies
A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple

applications
Period Prevalence of Ketamine-Propofol Admixture "Ketofol" in the Operating Room among

Anesthesia Providers at an Academic Medical Center
Mechanical, thermal and bio-compatibility studies of PAEK-hydroxyapatite nanocomposites
In vitro and in vivo evaluation of Δ⁹-tetrahidrocannabinol/PLGA nanoparticles for cancer

chemotherapy
Modified hydroxypropyl methyl cellulose: Efficient matrix for controlled release of 5-amino
salicylic acid
Nano-anisotropic surface coating based on drug immobilized pendant polymer to suppress

macrophage adhesion response
Analysis of remifentanil with liquid chromatography-tandem mass spectrometry and an

extensive stability investigation in EDTA whole blood and acidified EDTA plasma
The optimal extracting process, manufacturing technique and biological evaluation of

Lithospermum erythrorhizon microcapsules
Stability of clonidine suspension in oral plastic syringes

Pretreatment with skin permeability enhancers: importance of duration and composition on
the delivery of diclofenac sodium
A review of the compatibility of liposome bupivacaine with other drug products and commonly
used implant materials
Study on efficacy of compatibility between aconiti radix cocta and Pinelliae Rhizoma on basis
of uniform design method
Elucidation of the transport mechanism of baicalin and the influence of a Radix Angelicae
Dahuricae extract on the absorption of baicalin in a Caco-2 cell monolayer model
Change in dissolution of chemical components of frankincense-myrrh before and after their

compatibility and effect on no release of LPS-induced macrophage cells
Design and in vitro evaluation of transdermal patches based on ibuprofen-loaded electrospun

fiber mats
Chemometric approach for development, optimization, and validation of different

chromatographic methods for separation of opium alkaloids
Evaluation of ionotropic cross-linked chitosan/gelatin B microspheres of tramadol

hydrochloride
Development and characterization of eudragit RS 100 loaded microsponges and its colonic
delivery using natural polysaccharide
Studies on pharmacokinetics of ferulic acid, Rhizoma Chuanxiong and Naodesheng capsule in

rat
The evaluation of ketoprofen pharmaceutical availability in the presence of a dry extract from
goldenrod (Solidago virgaurea L.) of synthetic polymer vehicles
Compatibility and stability of ternary admixtures of tramadol, haloperidol, and hyoscine N-

butyl bromide: retrospective clinical evaluation
Compatibility and stability of binary mixtures of acetaminophen, nefopam, ketoprofen and

ketamine in infusion solutions
Formulation and evaluation of curcumin gel for topical application

Design and evaluation of transdermal drug delivery system for curcumin as an anti-
inflammatory drug
Carboxymethyl mungbean starch as a new pharmaceutical gelling agent for topical

preparation
Simultaneous determination of ketamine, tramadol, methadone, and their metabolites in

urine by gas chromatography-mass spectrometry
The development of microthermal analysis and photothermal microspectroscopy as novel

approaches to drug-excipient compatibility studies
Design and evaluation of mucoadhesive vaginal tablets of tenofovir disoproxil fumarate for
pre-exposure prophylaxis of HIV
A novel spectroscopic analysis to detect photochemical reaction of the bronchodilator -

Doxofylline and its estimation in pharmaceutical formulation
Formulation and Evaluation of Sol-Gel Drug Delivery System for Intracanal pH Sensitive
Controlled Delivery of Chlorhexidine
Influence of Peroxide Impurities in Povidone on the Stability of Selected β-Blockers with the
Help of HPLC
Pseudopolyrotaxane Formation in the Synthesis of Cyclodextrin Polymers: Effects on Drug

Delivery, Mechanics, and Cell Compatibility
Sustained release gastroretentive tablet of metformin hydrochloride based on poly (acrylic

acid)-grafted-gellan
A pragmatic approach to the analysis of a combination formulation
Delivery of Thermoresponsive-Tailored Mixed Micellar Nanogel of Lidocaine and Prilocaine

with Improved Dermatokinetic Profile and Therapeutic Efficacy in Topical Anaesthesia
OLANZAPINE-PEG 6000 BINARY SYSTEMS: IN VITRO DISSOLUTION BEHAVIOR,

PHYSICOCHEMICAL CHARACTERIZATION AND MATHEMATICAL MODELING
Preparation and characterization of isoniazid and lamivudine co-loaded polymeric

microspheres
Design and development of controlled release floating matrix tablet of Nicorandil using
hydrophilic cellulose and pH-independent acrylic polymer: in-vitro and in-vivo evaluations
Application of Central Composite Design in Optimization of Valsartan Nanosuspension to

Enhance its Solubility and Stability
Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of
buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies
Formulation Development of Spherical Crystal Agglomerates of Itraconazole for Preparation of

Directly Compressible Tablets with Enhanced Bioavailability
Nevirapine loaded Poloxamer 407/Pluronic P123 mixed micelles: Optimization of formulation

and in vitro evaluatio
An optimized probucol microencapsulated formulation integrating a secondary bile acid

(deoxycholic acid) as a permeation enhance
Formulation and evaluation of floating tablet of H2-receptor antagonist
Pharmaceutical and pharmacokinetic evaluation of a novel fast dissolving film formulation of

flupentixol dihydrochloride
Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid

formulation: a characterization study
Solid-state stability and compatibility studies of clavulanate potassium
Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix

forming excipient for controlled drug delivery
characterization
Studies on stercuia gum formulations in the form of osmotic core tablet for colon-specific
drug delivery of azathioprine
Compatibility studies of nevirapine in physical mixtures with excipients for oral HAART
Development of novel floating delivery system based on psyllium: application on metformin
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A compatibility study of a secondary amine active pharmaceutical ingredient with starch:

identification of a novel degradant formed between desloratadine and a starch impurity using
LC-MS(n) and NMR spectroscopy
Effect of different polymers and their combinations on the release of metoclopramide HCl from
sustained-release hydrophilic matrix tablets
In vitro cytotoxicity and cellular uptake of curcumin-loaded Pluronic/Polycaprolactone micelles

in colorectal adenocarcinoma cells
Lornoxicam gastro retentive floating matrix tablets: Design and in vitro evaluation
Design and development of a stable polyherbal formulation based on the results of

compatibility studies
The solution, solid state stability and kinetic investigation in degradation studies of
lercanidipine: study of excipients compatibility of lercanidipine
In vitro characterization and release study of Ambroxol hydrochloride matrix tablets prepared
by direct compression
Thermal and non-thermal methods to evaluate compatibility of granisetron hydrochloride with

tablet excipients
Design and in vitro evaluation of zidovudine oral controlled release tablets prepared using
hydroxypropyl methylcellulose
Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-

beta-cyclodextrin
Compatibility and stability of valsartan in a solid pharmaceutical formulation
Floating tablets of hydralazine hydrochloride: optimization and evaluation
Análise térmica aplicada à caracterização da sinvastatina em formulações farmacêuticas

Síntesis, caracterización fisicoquímica y del estado sólido de asparaginatos de cobre,
magnesio, manganeso y zinc
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Avaliação das propriedades de fluxo dos granulados e dissolução de comprimidos de

hidroclorotiazida 50 mg obtidos por granulação úmida
La sinergia farmacológica aplicada a la analgesia: revisión de la combinación de ibuprofeno con

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Perfil de dissolução in vitro de comprimidos de primaquina disponíveis para tratamento de

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Estabilidad y compatibilidad de la mezcla de tramadol, ketorolaco, metoclopramida y ranitidina

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Development of tablets containing semipurii ed extract of guaraná (Paullinia cupana)
Synthesis, Characterization, and Crystal Chemistry of Tasimelteon, a Melatonin Agonist, in Its

Anhydrous and Hemihydrate Forms
Self-emulsifying excipient platform for improving technological properties of alginate–

hydroxypropylcellulose pellets
Thermal behavior and stability of biodegradable spray-dried microparticles containing

triamcinolone
Stability and in vitro release profile of enalapril maleate from different commercially available
tablets: Possible therapeutic implications
Synthesis, molecular properties, toxicity and biological evaluation of some new substituted
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Amino acid based amphiphilic copolymer micelles as carriers of non-steroidal anti-

inflammatory drugs: Solubilization, in vitro release and biological evaluation
Naturally derived anti-inflammatory compounds from Chinese medicinal plants
Evaluation of the anti-inflammatory and analgesic properties of individual and combined

extracts from Commiphora myrrha, and Boswellia carterii
Development of novel transdermal self-adhesive films for tenoxicam, an anti-inflammatory

drug
Drug–excipient compatibility screening—Role of thermoanalytical and spectroscopic

techniques
Design of an Anti-Inflammatory Composite Nanosystem and Evaluation of Its Potential for

Ocular Drug Delivery
Emu oil based nano-emulgel for topical delivery of curcumin
Preparation of highly stable diclofenac potassium pellet with microcrystalline cellulose by

extrusion–spheronization
The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum

seeds: Focus on the freeze-dried matrix forming capacity
Development of Poloxamer Gel formulations via Hot-Melt Extrusion Technology
Sponge like microparticles for drug delivery and cosmeto-textile use: Formulation and human
skin penetration
Self-assembly of a ibuprofen-peptide conjugate to suppress ocular inflammation
Multi-target approach for natural products in inflammation
An approach for rapid development of nasal delivery of analgesics—Identification of relevant

features, in vitro screening and in vivo verification
Enhancement of dissolution rate and bioavailability of aceclofenac: A chitosan-based solvent

change approach
Microsponges based novel drug delivery system for augmented arthritis therapy
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous

delivery of ibuprofen assessed in vivo in rats
Impact of in situ granulation and temperature quenching on crystal habit and micromeritic
properties of ibuprofen-cationic dextran conjugate crystanules
Solubility of Ketoprofen in colloidal PLGA
Chapter 21 - Development of Modified-Release Solid Oral Dosage Forms
Design and evaluation of bi-layer pump tablet of flurbiprofen solid dispersion for zero-order
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Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays

for transdermal delivery of high dose, low molecular weight drugs
Development of mucoadhesive and thermosensitive eyedrops to improve the ophthalmic

bioavailability of ibuprofen
An assessment of the interactions between diclofenac sodium and ammonio methacrylate

copolymer using thermal analysis and Raman spectroscopy
Simultaneous colorimetric determination of morphine and ibuprofen based on the aggregation

of gold nanoparticles using partial least square
Advantages and challenges offered by biofunctional core–shell fiber systems for tissue
engineering and drug delivery
Electrospun diclofenac sodium loaded Eudragit® L 100-55 nanofibers for colon-targeted drug
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The effects of cryoprotectants on the freeze-drying of ibuprofen-loaded solid lipid

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Solid-state compatibility studies using a high-throughput and automated forced degradation

system
Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the
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Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine

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Quality by design approach for formulation development: A case study of dispersible tablets
Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets
Development and characterization of ketorolac tromethamine osmotic pump tablets
Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques
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transdermal administration in dysmenorrhea model mice
Quantitatively analyze composition principle of Ma Huang Tang by structural equation

modeling
Preparation and characterization of Beta vulgaris pulp powder as a pharmaceutical excipient
Experimental optimization of Lornoxicam liposomes for sustained topical delivery
Recrystallized agglomerated meloxicam: evaluation of anti-nociceptive effect
Determination of tramadol and metabolites by HPLC-FL and HPLC–MS/MS in urine of dogs
Triple-component nanocomposite films prepared using a casting method: Its potential in drug
delivery
Development of an enhanced formulation for delivering sustained release of buprenorphine

hydrochloride
Surface modification of acetaminophen particles by atomic layer deposition
Evaluation of supercritical fluid chromatography for testing of PEG adducts in pharmaceuticals
Influence of plasticizers on the stability and release of a prodrug of Δ9-tetrahydrocannabinol

incorporated in poly (ethylene oxide) matrices
Anti-inflammatory effect of Sanshuibaihu decoction may be associated with nuclear factor-κB

and p38 MAPKα in collagen-induced arthritis in rat
Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage
forms
Drug-excipient compatibility assessment of solid formulations containing meloxicam
Pharmaceutical excipients — quality, regulatory and biopharmaceutical considerations
Screening for stability and compatibility conditions of recombinant human epidermal growth
factor for parenteral formulation: Effect of pH, buffers, and excipients
Use of mixture design in drug-excipient compatibility determinations: Thymol nanoparticles

case study
Solid state compatibility studies with tablet excipients using non thermal methods
Nanostructured lipid carrier (NLC) based gel of celecoxib
Screening of topical gel containing lycopene and dexamethasone against UV radiation induced
photoaging in mice
Melt-Cast Noninvasive Ocular Inserts for Posterior Segment Drug Delivery
Selection of high efficient transdermal lipid vesicle for curcumin skin delivery
Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive
intestinal peptide derivative ([R15, 20, 21, L17, A24,25, des-N28]-VIP-GRR) in experimental
asthma/COPD model rats
PLA/F68/Dexamethasone implants prepared by hot-melt extrusion for controlled release of

anti-inflammatory drug to implantable medical devices: I. Preparation, characterization and
hydrolytic degradation study
Novel chewable colon targeted tablets of bumadizone calcium for treatment of ulcerative
colitis: Formulation and optimization
Improved and Safe Transcorneal Delivery of Flurbiprofen by NLC and NLC-Based Hydrogels
Development and in-vitro evaluation of controlled release matrix tablets of isradipine

employing various natural polymers
Formulation and evaluation of flupirtine maleate sustain release matrix tablets
RP-LC gradient elution method for simultaneous determination of related substances of

zaltoprofen and paracetamol and application for drug excipient compatibility study
Formulation and evaluation of zaltoprofen nanoemulsion gel
Formulation and characterisation of Tizanidine hydrochloride loaded ethosomes patch

AUTOR (ES)
Halil İbrahim Ulusoy & Ramazan Gürkan
Mario Isiordia E.1, Amaury Pozos Guillén2, Patricia Aguirre B.3, José Pérez U.3
Alejandra Santana-Cruz,1 Jorge Luis Flores-Moreno,*,1 Roberto Guerra-González2

and María de Jesús Martínez-Ortiz3
Yazmín K. Márquez-Floresa, Hortensia Montellano-Rosalesb, Ma. Elena Campos Aldretec , Ma.

Estela Meléndez-Camargoa
Janaina C. O. Villanova, Rodrigo L. Oréfice; Armando S. Cunha
K. Basavaiah* , B.C. Somashekar
Loyola Vargas, Víctor M.; Sánchez Iturbe, Patricia; Canto Canché, Blondy; Gutiérrez Pacheco, Luis
C.;
Galaz Ávalos, Rosa M.; Moreno Valenzuela, Oscar
Dary L. MENDOZA M.1*

, Stephanie SAAVEDRA A.2
KARENT BRAVO ;JAIME ANDRÉS PEREAÑEZ

Samayoa-Sandoval, Liliana; Villafuerte-Robles, Leopoldo
Boeris, Mónica Alejandra; Toso, Ricardo Enrique
Bernabé-Galloway, Patricia; Argüelles-Monal, Waldo; Peniche-Covas, Carlos
Sekaran, C. Bala; Rani, A. Prameela
Castro-Pastrana, Lucila I.; Baños-Medina, María I.; López-Luna, María Argelia; TorresGarcía, Blanca
L
MORA G., Carolina P.; BARBOSA B., Helber J.; MARTÍNEZ R., Fleming
Cedillo-Ramírez, Erika; Hernández-León, Alejandra; Villafuerte-Robles, Leopoldo
Manente, Francine Alessandra; de Almeida Mello, Lucas Rosolen; Arafat Kdudsi Khalil, Omar; de
Carvalho, Cláudio Teodoro; Bannach, Gilbert; Rebuglio Vellosa, José Carlos
Lozano, Maribel; Gonzales, Eduardo; Flores, Yonny; Almanza, Giovanna R.
Gonçalves, Vanessa L.; Laranjeira, Mauro C. M.; Fávere, Valfredo T.; Pedrosa, Rozângela C
Espinoza Ramos, Rogelio; Villafuerte Robles, Leopoldo
Chávez-Piña, Aracely Evangelina; González-García, Martha Patricia; Jiménez-Andrade, Juan Miguel
Correa Cuevas, Laura Paloma; Hernández Baltazar, Efrén
Ojeda Armaignac, Elaine; Hing Cortón, Romelia

García P, Guadalupe; Río T., Rosa Elva del; Guzmán M., Ramón; Martínez G., María Isabel; Scior,
Thomas R. F
Pérez Bueno, T.; Sánchez Miranda, L.; Rosado Ruiz-Apodaca, I.; Correa Rivero, H.; Lazo, R.; Pérez,
A.; Riverón, Y.; González, D.; Martínez, S.
Saucedo-Hernández, Yanelis; González-Bedia, Mirtha Mayra; Bravo-Sánchez, Luis Ramón;

GonzálezSan Miguel, Hilda M.; Paul-Remon, Jean; Antunes, Andre; Huyghebaert, Nathalie;
Gonnissen, Yves; Jorge-Rodríguez, María Elisa; Alba-de Armas, Miguel Ángel
Herrera E., Ana María; López G., José Julián
Delgado, Daniel R.; Peña, María Á.; Martínez, Fleming
D. C. Vila, M. M.; Salomão, A. A.; Tubino, M
Bencomo-Martínez, Alberto; Sablón-Carrazana, Marquiza; Rivera-Marrero, Suchitil; Rodríguez-

Tanty, Chryslaine; Álvarez-Ginarte, Yoanna María; Pupo-Meriño, Amaury
Zúñiga-Hidalgo, Tania; León-Rosario, Gabriela; Hernández-Baltazar, Efrén; Melgoza-Contreras, Luz

María
Velázquez González, Karen Alejandra; Ramírez Flores, Eduardo; Villafuerte Robles, Leopoldo
León-Rojas, Andrés Felipe; Urbina-González, Juan Manuel
BAENA A., Yolima; MANZO, Rubén H.; PONCE D'LEÓN Q., Luisa F.
Rivera-Marrero, Suchitil; Sablón-Carrazana, Marquiza; López-Barroso, Rosa María; Pérez-Perera,

Rafaela; Perera-Pintado, Alejandro; Prats-Capote, Anaís; Garrido-Arteaga, Raine; Sánchez-Puente,
Aniel; Rodríguez-Tanty, Chryslaine
Guzmán, Angel; Díaz, Eduardo; Trejo, Blanca E.; López Muñoz, Francisco J.
Mancilla, Teresa; Correa-Basurto, José; Alavés Carbajal, Karla S.; Sánchez Escalante, Evelyn T. J.;
Trujillo Ferrara, José
Domínguez Hernández, Liliana; Hohlatcheff Ávila, Ana Laura; Montiel Hernández, José Luis
Bellich, Barbara
Pereira, Rafael Nicolay
Reza Enayatifard , Jafar Akbari , Majid Saeedi , Katayoun Morteza-Semnani , Amir-Hasan Kasiri
Diwakar Manohar, Pachabhai
Chauhan, Shefali S.
Meenal Mukund Rane
Nwoko Valentine E
K. Ranjith Kumar
and D.V. R. N. Bhikshapathi
Prachi Pandey, S. S Pancholi
V. Hemalatha*, N. Mounika, A. Devi Chandini, K. Geethika, M. Indraja, K. Ramya and P. Srinivasa

Babu
Melissa R Cardoz*and Padmini Ravikumar
Dumitru Tita;Tunde Jurca; Adriana Fulias; Eleonora Marian; Bogdan Tita

Nagasree K*, Chowdary GV & Mahendra Kumar CB
Limce Thampi; M Swamivel Manickam; S Kuppuswamy
M. L. Vueba, F. Veiga, J. J. Sousa & Prof. Maria Eugénia Pina
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Meka , Udupa Nayanabhirama & Pandey Sureshwar
Dustin L Cooper, Christopher M Conder & Sam Harirforoosh
Karrie Marren
Amira Motawea, Thanaa Borg, Manal Tarshoby & Abd El-Gawad H. Abd El-Gawad
Yassin El-Said Hamza & Mona Hassan Aburahma
M. L. Vueba , L. A. E. Batista de Carvalho, F. Veiga, J. J. Sousa & M. E. Pina
Jaleh Varshosaz , Naser Tavakoli & Azadeh Serri
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Sambaraj S, Ammula D, Nagabandi V.
Rozman Peterka T, Grahek R, Hren J, Bastarda A, Bergles J, Urleb U
Koteswari P, Sunium S, Srinivasababu P, Babu GK, Nithya PD

Niyonzima FN, More SS
Moosa RM, Choonara YE, du Toit LC, Tomar LK, Tyagi C, Kumar P, Carmichael TR, Pillay V.
Negi LM, Jaggi M, Talegaonkar S
Zhang W, Parniak MA, Sarafianos SG, Cost MR, Rohan LC.
Ucisik MH, Küpcü S, Schuster B, Sleytr UB
Shiny J, Ramchander T, Goverdhan P, Habibuddin M, Aukunuru JV
Chadha R, Bhandari S
Shete H, Patravale V.
Narala A, Veerabrahma K
Sunil SA, Srikanth MV, Rao NS, Raju V, Murthy KV
Antovska P, Petruševski G, Makreski P
Bohanec S, Peterka TR, Blažič P, Jurečič R, Grmaš J, Krivec A, Zakrajšek J.
Youssef T, Fadel M, Fahmy R, Kassab K.
Soares-Sobrinho JL, de La Roca Soares MF, Lopes PQ, Correia LP, de Souza FS, Macêdo RO, Rolim-
Neto PJ.
Guo D, Myrdal PB, Karlage KL, O'Connell SP, Wissinger TJ, Tabibi SE, Yalkowsky SH.
Wu Y, Dali M, Gupta A, Raghavan K
Kartal A, Björkqvist M, Lehto VP, Juppo AM, Marvola M, Sivén M
Singh J, Philip AK, Pathak K.
Agatonovic-Kustrin S, Markovic N, Ginic-Markovic M, Mangan M, Glass BD
van de Donk NWCJ, Richardson PG, Malavasi F
Sun L, Ding F, You G, Liu H, Wang M, Ren X, Deng Y
Mu Q, Yu J, McConnachie LA, Kraft JC, Gao Y, Gulati GK, Ho RJY
Hirpara MR, Manikkath J, Sivakumar K, Managuli RS, Gourishetti K, Krishnadas N, Shenoy RR,
Jayaprakash B, Rao CM, Mutalik S
Koteswari P, Sravanthi GP, Mounika M, Mohammed Rafi SK, Nirosha K
Elnaggar YS, Talaat SM, Bahey-El-Din M, Abdallah OY
Zakaria AS, Afifi SA, Elkhodairy KA.
Bonsu MA, Ofori-Kwakye K, Kipo SL, Boakye-Gyasi ME, Fosu MA
Moin A, Raizaday A, Hussain T, Nagshubha B

Dhiman N, Awasthi R, Jindal S, Khatri S, Dua K
Khan G, Yadav SK, Patel RR, Nath G, Bansal M, Mishra B
Kumar P, Ganure AL, Subudhi BB, Shukla S
Singh B, Kaur A, Dhiman S, Garg B, Khurana RK, Beg S
Qiu C, Cui YL, Qi XJ, Jiang HL, Wang QS.
Jogala S, Rachamalla SS, Aukunuru J
Sharma D, Singh G, Kumar D, Singh M
Du Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A
Reddy GS, Nayak UY, Deshpande PB, Mutalik S
Abdelkader H, Pierscionek B, Alany RG
Ladola MK, Gangurde AB
Lu HQ, Lu W, Liu J, Yang KJ, Li ZG
Sharma A, Sharma J, Kaur R, Saini V
Bansal S, Beg S, Asthana A, Garg B, Asthana GS, Kapil R, Singh B

Gupta V, Singh S, Srivarstava M, Ahmad H, Pachauri SD, Khandelwal K, Dwivedi P, Dwivedi AK
Khan MS, Vishakante GD, Bathool A
Rao TV, Kumar GK, Ahmed MG, Joshi V
Sravya M, Deveswaran R, Bharath S, Basavaraj BV, Madhavan V
Gupta A, Aggarwal G, Singla S, Arora R
Dholakia M, Thakkar V, Patel N, Gandhi T
Masareddy R, Kokate A, Shah V
Nesseem DI, Michel CG
Yang HY, Zheng XH, Du Y, Chen Z, Zhu DY, Lou YJ
Kumar S, Nagpal K, Singh S, Mishra D
Vaghani SS, Patel SG, Jivani RR, Jivani NP, Patel MM, Borda R
Senthil V, Kumar RS, Nagaraju CV, Jawahar N, Ganesh GN, Gowthamarajan K
Nirale NM, Menon MD.
Mohan Kamila M, Mondal N, Kanta Ghosh L, Kumar Gupta B

Kauss T, Marchivie M, Phoeung T, Gaubert A, Désiré A, Tonelli G, Boyer C, Langlois MH, Cartwright
A, Gomes M, White N, Gaudin K
Alves-Silva I, Marreto RN, Gelfuso GM, Sá-Barreto LC, Lima EM, Cunha-Filho MS
Kumar A, Jain SK
Diós P, Nagy S, Pál S, Pernecker T, Kocsis B, Budán F, Horváth I, Szigeti K, Bölcskei K, Máthé D,
Dévay A
Badenhorst T, Svirskis D, Wu Z
Ceresole R, Han YK, Rosasco MA, Orelli LR, Segall A
Wesolowski M, Rojek B, Piotrowska J
Vijay J, Sahadevan J, Prabhakaran R, Gilhotra RM
Borhade V, Pathak S, Sharma S, Patravale V
Zhang SQ, Rahman Z, Thumma S, Repka MA, Chen GH, Li SM
Chrzanowski F
Saikia C, Das MK, Ramteke A, Maji TK
Fusi-Schmidhauser T, Caronzolo D, Gamondi C
Wuytack F, Smith V, Cleary BJ

Liao W, Yu J, Guo Z, Ba W, Wang D, Li Z, Fan W, Liao F, Wu Y, Wang L
Elzayat EM, Abdel-Rahman AA, Ahmed SM, Alanazi FK, Habib WA, Sakr A
Kalita B, Das MK, Sarma M, Deka A
Cosentino V, Fratter A, Cosentino M
Almeida H, Lobão P, Frigerio C, Fonseca J, Silva R, Palmeira-de-Oliveira A, Lobo JM, Amaral MH
Wang Q, Ye M, Xu L, Shi ZG
Olson AN, Rao WR, Marienau ME, Smischney NJ
Roy P, Sailaja RR
Martín-Banderas L, Muñoz-Rubio I, Prados J, Álvarez-Fuentes J, Calderón-Montaño JM, López-

Lázaro M, Arias JL, Leiva MC, Holgado MA, Fernández-Arévalo M
Das R, Pal S
Kaladhar K, Renz H, Sharma CP
Koster RA, Vereecke HE, Greijdanus B, Touw DJ, Struys MM, Alffenaar JW
Lou CW, Chang CY, Wu ZH, Lin JH
Ma C, Decarie D, Ensom MH
Maurya A, Murthy SN
Kharitonov V
Liu CF, Tan SF, Wang DH, Zhang YQ, Lin N
Zhu ML, Liang XL, Zhao LJ, Liao ZG, Zhao GW, Cao YC, Zhang J, Luo Y
Chen T, Su SL, Duan JA, Shang EX, Qian DW, Tang YP
Shi Y, Xu S, Dong A, Zhang J
Acevska J, Stefkov G, Petkovska R, Kulevanova S, Dimitrovska A
Basu SK, Kavitha K, Rupeshkumar M
Jain V, Singh R
Ou Y, Pan L, Tang J, Yang Y, Wang B
Berner-Strzelczyk A, Kołodziejska J, Piechota-Urbańska M, Zgoda MM
Negro S, Martín A, Azuara L, Sánchez Y, Barcia E
Hamdi M, Lentschener C, Bazin C, Ozier Y, Havard L
Patel NA, Patel NJ, Patel RP

Patel NA, Patel NJ, Patel RP
Kittipongpatana OS, Burapadaja S, Kittipongpatana N
Cheng PS, Lee CH, Liu C, Chien CS
Harding L, Qi S, Hill G, Reading M, Craig DQ
Khan AB, Thakur RS
Sasi Rekha P, Gunasekaran S
Gandhi K, Maganti RS, Kaur H, Vinod KS, Verma P
Prachi S, Komal C, Priti MJ
Thatiparti TR, Juric D, von Recum HA
Sarkar D, Nandi G, Changder A, Hudati P, Sarkar S, Ghosh LK
Mubtasim N, Kabir ER, Podder AK, Bhadra S
Sharma G, Kamboj S, Thakur K, Negi P, Raza K, Katare OP
Krishnamoorthy V, Suchandrasen, Prasad VP
Pandey G, Yadav SK, Mishra B

Ahmed AB, Nath LK
Vuppalapati L, Cherukuri S, Neeli V, Yeragamreddy PR, Kesavan BR
Jaipal A, Pandey MM, Charde SY, Raut PP, Prasanth KV, Prasad RG
Fadke J, Desai J, Thakkar H
Jindal N, Mehta SK
Mooranian A, Negrulj R, Chen-Tan N, Watts GF, Arfuso F, Al-Salami H
Kesarla RS, Vora PA, Sridhar BK, Patel G, Omri A
Abdelbary A, Bendas ER, Ramadan AA, Mostafa DA
Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur T, Mikov M, Golocorbin-Kon S,

Fakhoury M, Arfuso F, Al-Salami H
Cielecka-Piontek J, Paczkowska M, Zalewski P, Lewandowska K, Barszcz B
Campiñez MD, Aguilar-de-Leyva Á, Ferris C, de Paz MV, Galbis JA, Caraballo I
Hiremath JG, Khamar NS, Palavalli SG, Rudani CG, Aitha R, Mura P
Nath B, Nath LK
de Oliveira GG, Ferraz HG, Severino P, Souto EB

Rathnanand M, Narkhede R, Udupa N, Kalra A
Yu X, Buevich AV, Li M, Wang X, Rustum AM
Savaşer A, Taş Ç, Bayrak Z, Özkan CK, Özkan Y
Raveendran R, Bhuvaneshwar G, Sharma CP
Sathiyaraj S, Devi RD, Hari VB
Bhope SG, Nagore DH, Kuber VV, Gupta PK, Patil MJ
Parmar N, Amin S, Singla N, Kohli K
Abd-Elbary A, Haider M, Sayed S
Late SG, Banga AK
Ravi PR, Ganga S, Saha RN
Corti G, Cirri M, Maestrelli F, Mennini N, Mura P
Júlio, Tamíris Amanda; Zâmara, Igor Fernando; Garcia, Jerusa Simone; Trevisan, Marcello Garcia
Vanitha, Kondi; Varma, Mohan; Ramesh, Alluri
Oliveira, Marcelo Antonio de; Yoshida, Maria Irene; Gomes, Elionai Cassiana de Lima; Mussel,
Wagner da Nova; Vianna-Soares, Cristina Duarte; Pianetti, Gérson Antônio
Benavides Arévalo, Julie Fernanda; Tobón Zapata, Gloria Elena
Martínez Álvarez, Luis Octavio; Mena Salabarría, Keila; Céspedes Pérez, Mirelys
Martínez Álvarez, Luis Octavio; Montes Pérez, Marlene
Lamolha, Marco Aurélio; Serra, Cristina Helena dos Reis
González-Escalada, J.R.
Rodrigues, Letícia Norma Carpentieri; Ferraz, Humberto Gomes; Watanabe, Sayuri Pereira
Cabrera, J.; Mancuso, M.; Cabrera-Fránquiz, F.; Limiñana, J.; Díez, A
Klein, Traudi; Longhini, Renata; Bruschi, Marcos Luciano; Palazzo de Mello, João Carlos
Ventimiglia, Giampiero; Bellomi, Sonja; Barreca, Giuseppe; Giovannelli, Lorella; Masciocchi,

Norberto
Mannina, Paolo; Segale, Lorena; Giovannelli, Lorella; Bonda, Andrea Foglio; Pattarino, Franco
da Silva-Junior, Arnóbio Antônio; de Matos, Jivaldo Rosário; Formariz, Thalita Pedroni; Rossanezi,
Gustavo; Scarpa, Maria Virginia; do Egito, Eryvaldo Sócrates Tabosa; de Oliveira, Anselmo Gomes
Lima, Dione Marçal; dos Santos, Leandro Dias; Lima, Eliana Martins
Husain, Asif; Ahmad, Aftab; Khan, Shah Alam; Asif, Mohd; Bhutani, Rubina; Al-Abbasi, Fahad A.
Dutta, Pranabesh; Dey, Joykrishna; Perumal, Venkatesan; Mandal, Mahitosh

Wang, Qiuhong; Kuang, Haixue; Su, Yang; Sun, Yanping; Feng, Jian; Guo, Rui; Chan, Kelvin
Su, Shulan; Hua, Yongqing; Wang, Yanyan; Gu, Wei; Zhou, Wei; Duan, Jin-ao; Jiang, Haifeng; Chen,
Ting; Tang, Yuping
Nesseem, Demiana I.; Eid, S.F.; El-Houseny, S.S
Chadha, Renu; Bhandari, Swati
Du Toit, Lisa C.; Govender, Thirumala; Carmichael, Trevor; Kumar, Pradeep; Choonara, Yahya E.;
Choonara, Yahya E; Pillay, Viness
Jeengar, Manish Kumar; Rompicharla, Sri Vishnu Kiran; Shrivastava, Shweta; Chella, Naveen;
Shastri, Nalini R.; Naidu, V.G.M.; Sistla, Ramakrishna
Wang, Yueqi; Huang, Hao; Zhang, Chungang; Tang, Yilin; Li, Jinzhuo; Tang, Xing; Cai, Cuifang
Iurian, Sonia; Dinte, Elena; Iuga, Cristina; Bogdan, Cătălina; Spiridon, Iuliana; Barbu-Tudoran,
Lucian; Bodoki, Andreea; Tomuţă, Ioan; Leucuţa, Sorin E
Mendonsa, Nicole S.; Murthy, S. Narasimha; Hashemnejad, Seyed Meysam; Kundu, Santanu;
Zhang, Feng; Repka, Michael A
Zafar, Nadiah; Robin, Sophie; Viennet, Céline; Humbert, Philippe; Valour, Jean Pierre; Agusti,
Geraldine; Fessi, Hatem; Elaissari, Abdelhamid
Yu, Xinxin; Zhang, Zhaoliang; Yu, Jing; Chen, Hao; Li, Xingyi
Koeberle, Andreas; Werz, Oliver
Wang, Shu; Chow, Moses S.S.; Zuo, Zhong
Mutalik, Srinivas; Anju, Parambil; Manoj, Krishnan; Usha, Achutha Nayak

Osmani, Riyaz Ali M.; Aloorkar, Nagesh H.; Ingale, Dipti J.; Kulkarni, Parthasarathi K.; Hani, Umme;
Bhosale, Rohit R.; Jayachandra Dev, Dandasi
Djekic, Ljiljana; Martinovic, Martina; Stepanović-Petrović, Radica; Micov, Ana; Tomić, Maja;
Primorac, Marija
bioye, Amos Olusegun; Kola-Mustapha, Adeola; Ruparelia, Ketan
Kluge, Johannes; Mazzotti, Marco; Muhrer, Gerhard
Qiu, Yihong; Zhang, Guohua
Cheng, Lizhen; Li, Ting; Dong, Ling; Wang, Xiaoyu; Huo, Qiye; Wang, Haoyu; Jang, Zhujun; Shan,
Xinyu; Pan, Weisan; Yang, Xinggang
McCrudden, Maelíosa T.C.; Alkilani, Ahlam Zaid; McCrudden, Cian M.; McAlister, Emma; McCarthy,
Helen O.; Woolfson, A. David; Donnelly, Ryan F
Almeida, Hugo; Lobão, Paulo; Frigerio, Christian; Fonseca, Joel; Silva, Renata; Quaresma, Pedro;
Lobo, José Manuel Sousa; Amaral, Maria Helena
Sipos, Péter; Szűcs, Mária; Szabó, András; Erős, István
Bahram, Morteza; Madrakian, Tayyebeh; Alizadeh, Sakineh
Sperling, Laura E.; Reis, Karina P; Pranke, Patricia; Wendorff, Joachim H
Shen, Xiaxia; Yu, Dengguang; Zhu, Limin; Branford-White, Christopher; White, Kenneth;
Chatterton, Nicholas P.
Zhang, Lijuan; Liu, Lei; Qian, Yu; Chen, Yun
Wakasawa, Tatsuyoshi; Sano, Kyoko; Hirakura, Yutaka; Toyo’oka, Toshimasa; Kitamura, Satoshi
Wang, Xiuzhi; Wang, Puxiu; Huang, Chenglong; Lin, Xiaoyang; Gong, Haoyu; He, Haibing; Cai,
Cuifang
de Oliveira, G.G.G.; Feitosa, A.; Loureiro, K.; Fernandes, A.R.; Souto, E.B.; Severino, P.
Charoo, Naseem A.; Shamsher, Areeg A.A.; Zidan, Ahmed S.; Rahman, Ziyaur
Tawfeek, Hesham M.; Saleem, Imran Y.; Roberts, Matthew
Ali, A.A.;Sayed, O.M.
Pindelska, Edyta; Sokal, Agnieszka; Kolodziejski, Waclaw
Ding, Xue; Sun, Yuming; Wang, Qing; Pu, Tingting; Li, Xiaohui; Pan, Yaqing; Yang, Yang
He, Yu; Gai, Yuquan; Wu, Xianbin; Wan, Haitong
Bablu, Ram; Rishabha, Malviya; Mayank, Bansal; Kumar, Sharma Pramod
Joseph, Joshny; B.N., Vedha Hari; D., Ramya Devi
Farid, M.; El-Setouhy, D.A.; El-Nabarawi, M.A.; El-Bayomi, T.
Saccomanni, G.; Del Carlo, S.; Giorgi, M.; Manera, C.; Saba, A.; Macchia, M.
Gilani, Sadia; Mir, Sadullah; Masood, Momina; Khan, Abida Kalsoom; Rashid, Rehana; Azhar, Saira;
Rasul, Akhtar; Ashraf, Muhammad Nadeem; Waqas, Muhammad Khurram; Murtaza, Ghulam
Koocheki, S.; Madaeni, S.S.; Niroomandi, P

Kääriäinen, Tommi O; Kemell, Marianna; Vehkamäki, Marko; Kääriäinen, Marja-Leena; Correia,
Alexandra; Santos, Hélder A.; Bimbo, Luis M.; Hirvonen, Jouni; Hoppu, Pekka; George, Steven M;
Cameron, David C; Ritala, Mikko; Leskelä, Markku
Schou-Pedersen, Anne Marie V; Østergaard, Jesper; Johansson, Mats; Dubant, Stephane;

Frederiksen, Rune B; Hansen, Steen Honoré
Thumma, Sridhar; ElSohly, Mahmoud A.; Zhang, Shuang-Qing; Gul, Waseem; Repka, Michael A.
Yang, Min; Xiao, Changhong; Wu, Qifu; Niu, Maochang; Yao, Qi; Li, Kaiqin; Chen, Yuyao; Shi,
Caixia; Chen, Dechao; Feng, Guokai; Xia, Chenlai
Tiţa, Bogdan; Fuliaş, Adriana; Bandur, Geza; Marian, Eleonora
da Silveira LM, Fiorot AB, Xavier TP, Yoshida MI, de Oliveira MA
Elder, David P.; Kuentz, Martin; Holm, René
Santana, Héctor; González, Yaima; Campana, Patricia Targon; Noda, Jesús; Amarantes, Odalys;
Itri, Rosangela; Beldarraín, Alejandro; Páez, Rolando
Pires, Felipe Q.; Angelo, Tamara; Silva, Joyce K.R; Sá-Barreto, Lívia C.L; Lima, Eliana M; Gelfuso,
Guilherme M; Gratieri, Tais; Cunha-Filho, Marcílio S.S
Liltorp, Karin; Larsen, Trine Gorm; Willumsen, Birgitte; Holm, René
Joshi, Medha; Patravale, Vandana
Shah, Harshit; Mahajan, Shruti Rawal
Balguri, Sai Prachetan; Adelli, Goutham R.; Tatke, Akshaya; Janga, Karthik Yadav; Bhagav,
Prakash; Majumdar, Soumyajit
Zhao, Ying-Zheng; Lu, Cui-Tao; Zhang, Yi; Xiao, Jian; Zhao, Ya-Ping; Tian, Ji-Lai; Xu, Yan-Yan; Feng,
Zhi-Guo; Xu, Chong-Yong
Onoue, Satomi; Aoki, Yosuke; Matsui, Takuya; Kojo, Yoshiki; Misaka, Shingen; Mizumoto,
Takahiro; Yamada, Shizuo
Li, DeXia; Guo, Gang; Fan, RangRang; Liang, Jian; Deng, Xin; Luo, Feng; Qian, ZhiYong
Nour, Samia A.; Abdelmalak, Nevine Shawky; Naguib, Marianne J
Gonzalez-Mira, Elisabet; Nikolić, Saša; Calpena, Ana C; Egea, M. Antonia; Souto, Eliana B; García,
M. Luisa
Gupta, S.; Siripurapu, K.; Ramya Swathi, M.; Kalluri, M.; Srinivasa Rao, M.; Kishore Kumar Reddy,
B.
Arun Kumar, T.; Velmurugan, S.; Ravishankar, K.; Nagarjuna Reddy, G.
Karbhari, P.A.; Joshi, S.J.; Bhoir, S.I.
Choudhary, P.; Aparna, C.; Srinivas, P.
Nagadevi, B.; Kumar, K.S.; Venkanna, P.; Prabhakar, D.

CRITERIOS DE INCLUSIÓN
AÑO DE REVISTA INDEXADA CATEGORIA- FACTOR DE IMPACTO

IDIOMA
PUBLICACION COLCIENCIAS (F.I)
INGLÉS 2009 0
ESPAÑOL 2006 0.076
ESPAÑOL 2006 0.076
ESPAÑOL 2010 0.076
INGLÉS 2016 0.71
INGLÉS 2009 0.076
PORTUGUÉS 2010 0.123
INGLÉS 2007 0
ESPAÑOL 2004 0.71
ESPAÑOL 2000 0.71
ESPAÑOL 2000 0.71
INGLÉS 2013 0.259
INGLÉS 2016 0.259

ESPAÑOL 2013 0.076
ESPAÑOL 2009 0.063
INGLÉS 2010 0
ESPAÑOL 2015 0.076
ESPAÑOL 2007 0.259
ESPAÑOL 2007 0.076
PORTUGUÉS 2011 0
INGLÉS 2013 0
INGLÉS 2005 0.123
INGLÉS 2003 0.71
ESPAÑOL 2013 0.076
ESPAÑOL 2011 0.076
ESPAÑOL 2006 0.02

ESPAÑOL 2011 0.076
ESPAÑOL 2005 0.02
ESPAÑOL 2011 NOT FOUND
ESPAÑOL 2016 0.259
INGLÉS 2016 0.055
INGLÉS 2008 0
ESPAÑOL 2013 0.076
INGLÉS 2015 0.076
ESPAÑOL 2015 0.333
ESPAÑOL 2011 0.076
INGLÉS 2011 0.259
INGLÉS 2004 0.71

INGLÉS 2007 0.71
ESPAÑOL 2012 0.076
PORTUGUÉS 2008 NA
PORTUGUÉS 2009 NA
INGLÉS 2014 0.317
INGLÉS 2012 NA
INGLÉS 2013 NA
INGLÉS 2013 NA
INGLÉS 2016 1.106
INGLÉS 2017 0.34
INGLÉS 2017 3.6
INGLÉS 2013 1.953

INGLÉS 2015 2.531
INGLÉS 2016 0.302
PORTUGES 2003 NA
INGLÉS 2005 2.295
INGLÉS 2009 2.295
INGLÉS 2014 5.657
INGLÉS 2011 1.292
INGLÉS 2017 1.86
INGLÉS 2010 1.86
INGLÉS 2013 2.295
INGLÉS 2009 1.86
INGLÉS 2008 2.295
INGLÉS 2018 2.933
INGLÉS 2017 2.295

INGLÉS 2017 1.45
INGLÉS 2017 0
INGLÉS 2017 0.261
INGLÉS 2017 5.657
INGLÉS 2017 2.05
INGLÉS 2017 0.618
INGLÉS 2017 0.66
INGLÉS 2017 0.618
INGLÉS 2017 0.298
INGLÉS 2017 1.45
INGLÉS 2016 LIBRO
INGLÉS 2016 2.451
INGLÉS 2016 0.404
INGLÉS 2016 0.212

INGLÉS 2016 0.817
INGLÉS 2016 0.25
INGLÉS 2016 0.817
INGLÉS 2016 0.745
INGLÉS 2016 4.44
INGLÉS 2016 0.369
INGLÉS 2016 0.302
INGLÉS 2016 1.96
INGLÉS 2016 2.295
INGLÉS 2016 0.506
INGLÉS 2016 2.531
INGLÉS 2016 0.66
INGLÉS 2016 0.369
INGLÉS 2016 0.298

INGLÉS 2016 0.745
INGLÉS 2015 1.194
INGLÉS 2015 0.302
INGLÉS 2015 0.013
INGLÉS 2015 3.649
INGLÉS 2015 3.255
INGLÉS 2015 0.618
INGLÉS 2015 2.295
INGLÉS 2015 2.531
INGLÉS 2015 2.531
INGLÉS 2015 0.302
INGLÉS 2015 1.96
INGLÉS 2015 3.002
INGLÉS 2015 0.302

INGLÉS 2015 0.669
INGLÉS 2015 0.185
INGLÉS 2015 0.134
INGLÉS 2015 1.96
INGLÉS 2015 1.96
INGLÉS 2015 0.302
INGLÉS 2014 0.302
INGLÉS 2014 3.255
INGLÉS 2014 2.05
INGLÉS 2014 0.09
INGLÉS 2014 0.163
INGLÉS 2014 0.506
INGLÉS 2014 0.311
INGLÉS 2014 0.163

INGLÉS 2014 1.96
INGLÉS 2014 0.25
INGLÉS 2014 2.933
INGLÉS 2014 0.506
INGLÉS 2014 0.506
INGLÉS 2014 1.96
INGLÉS 2014 2.531
INGLÉS 2013 0.506
INGLÉS 2013 0.76
INGLÉS 2013 0.745
INGLÉS 2013 0.745
INGLÉS 2013 0.09
INGLÉS 2013 0.618
INGLÉS 2013 0.506

INGLÉS 2013 0.506
INGLÉS 2013 5.657
INGLÉS 2013 2.302
INGLÉS 2013 0.193
INGLÉS 2013 0
INGLÉS 2013 0.245
INGLÉS 2012 0.506
INGLÉS 2012 0.09
INGLÉS 2012 0.618
INGLÉS 2012 1.348
INGLÉS 2012 3.002
INGLÉS 2012 0.013
INGLÉS 2012 0.09
INGLÉS 2012 1.348

INGLÉS 2012 0.669
INGLÉS 2012 1.194
INGLÉS 2011 0.09
INGLÉS 2011 0.298
INGLÉS 2011 0.09
INGLÉS 2011 1.288
INGLÉS 2011 3.002
INGLÉS 2011 0
INGLÉS 2010 1.133
INGLÉS 2010 0.618
INGLÉS 2010 0.735
INGLÉS 2009 1.86
INGLÉS 2008 2.451
INGLÉS 2008 0.302

INGLÉS 2007 2.295
INGLÉS 2017 5.605
INGLÉS 2017 2.243
INGLÉS 2018 2.451
INGLÉS 2017 3.226
INGLÉS 2017 7.223
INGLÉS 2017 2.295
INGLÉS 2016 3.671
INGLÉS 2016 4.164
INGLÉS 2016 2.933
INGLÉS 2015 2.05
INGLÉS 2015 3.255
INGLÉS 2014 0.817

INGLÉS 2014 1.751
INGLÉS 2014 3.649
INGLÉS 2014 3.649
INGLÉS 2014 3.649
INGLÉS 2013 4.946
INGLÉS 2013 0.817
INGLÉS 2013 3.255
INGLÉS 2013 3.649
INGLÉS 2013 1.653
INGLÉS 2013 1.86
INGLÉS 2010 0.983
INGLÉS 2012 1.86
INGLÉS 2010 2.451

INGLÉS 2010 2.451
INGLÉS 2009 1.86
INGLÉS 2008 2.405
INGLÉS 2008 2.451
INGLÉS 2008 3.255
INGLÉS 2017 13.164
INGLÉS 2017 3.83
INGLÉS 2017 3.068
INGLÉS 2017 3.671
INGLÉS 2016 0.817
INGLÉS 2016 4.3
INGLÉS 2016 2.476
INGLÉS 2016 0
INGLÉS 2016 2.391

INGLÉS 2016 2.342
INGLÉS 2016 2.451
INGLÉS 2015 1.507
INGLÉS 2016 2.451
INGLÉS 2015 0.247
INGLÉS 2015 1.683
INGLÉS 2015 0
INGLÉS 2015 2.342
INGLÉS 2014 1.524
INGLÉS 2014 3.649
INGLÉS 2014 0.66
INGLÉS 2015 2.391
INGLÉS 2014 2.476
INGLÉS 2016 6.402

INGLÉS 2016 6.402
INGLÉS 2013 4.521
INGLÉS 2012 0.817
INGLÉS 2012 2.302
INGLÉS 2012 0.76
INGLÉS 2011 0.66
INGLÉS 2011 1.648
INGLÉS 2011 2.981
INGLÉS 2011 1.653
INGLÉS 2012 1.86
INGLÉS 2010 1.683
INGLÉS 2010 0.66
INGLÉS 2009 2.451

INGLÉS 2017 3.756
INGLÉS 2017 2.295
INGLÉS 2017 5.605
INGLÉS 2015 4.159
INGLÉS 2016 1.86
INGLÉS 2013 0.222
INGLÉS 2012 0.962
INGLÉS 2012 0.404
INGLÉS 2012 3.649
INGLÉS 2009 2.295
INGLÉS 2008 2.451
INGLÉS 2016 3.671
INGLÉS 2016 2.698
INGLÉS 2016 6.264

INGLÉS 2016 3.255
INGLÉS 2016 0.745
INGLÉS 2017 2.451
INGLÉS 2016 1.778
INGLÉS 2016 2.391
INGLÉS 2015 4.95
INGLÉS 2015 1.585
INGLÉS 2015 3.11
INGLÉS 2015 3.649
INGLÉS 2015 3.671
INGLÉS 2015 3.887
INGLÉS 2015 4.014
INGLÉS 2015 4.164
INGLÉS 2014 1.969

INGLÉS 2014 2.933
INGLÉS 2014 2.062
INGLÉS 2013 0.247
INGLÉS 2013 2.981
INGLÉS 2013 0.247
INGLÉS 2013 2.325
INGLÉS 2012 3.431
INGLÉS 2011 2.451
INGLÉS 2010 0.745
INGLÉS 2010 0.247
INGLÉS 2009 2.342
INGLÉS 2010 2.23
INGLÉS 2009 3.57
INGLÉS 2009 1.86

INGLÉS 2009 2.295
INGLÉS 2009 2.295
INGLÉS 2008 2.409
INGLÉS 2008 3.649
INGLÉS 2017 2.295
INGLÉS 2018 2.536
INGLÉS 2017 0.765
INGLÉS 2017 2.451
INGLÉS 2017 4.818
INGLÉS 2017 3.671
INGLÉS 2017 2.302
INGLÉS 2017 2.451
INGLÉS 2015 0.745
INGLÉS 2016 5.605

INGLÉS 2016 5.657
INGLÉS 2016 2.391
INGLÉS 2015 2.302
INGLÉS 2015 2.451
INGLÉS 2015 3.887
INGLÉS 2014 2.822
INGLÉS 2015 2.295
INGLÉS 2014 2.451
INGLÉS 2014 2.822
INGLÉS 2015 1.86
INGLÉS 2013 2.295
INGLÉS 2013 2.302
INGLÉS 2013 0.393
INGLÉS 2013 4.164

INGLÉS 2013 2.391
INGLÉS 2013 2.933
INGLÉS 2013 1.86
INGLÉS 2013 2.31
INGLÉS 2011 1.683
INGLÉS 2011 1.188
INGLÉS 2012 1.86
INGLÉS 2012 1.86
INGLÉS 2008 1.126
INGLÉS 2008 1.133
INGLÉS 2008 4.159
INGLÉS 2013 0.474
INGLÉS 2013 0.474

ESPAÑOL 2013 0.202
ESPAÑOL 2013 0.202
ESPAÑOL 2011 0.202
PORTUGUÉS 2007 NOT FOUND
ESPAÑOL 2010 0.157
ESPAÑOL 2011 0.372
INGLÉS 2013 1.059
INGLÉS 0 2.933
INGLÉS 2016 3.649
INGLÉS 2009 3.649
INGLÉS 2008 3.255
INGLÉS 2016 2.302
INGLÉS 2011 3.649

INGLÉS 2013 2.981
INGLÉS 2012 2.981
INGLÉS 2011 2.936
INGLÉS 2014 3.255
INGLÉS 2013 2.933
INGLÉS 2016 3.649
INGLÉS 2013 3.653
INGLÉS 2017 2.302
INGLÉS 0 3.649
INGLÉS 2017 3.649
INGLÉS 2018 5.72
INGLÉS 2014 6.369
INGLÉS 2011 3.649
INGLÉS 2008 3.649

INGLÉS 2015 2.302
INGLÉS 2016 3.756
INGLÉS 2014 3.649
INGLÉS 2010 3.649
INGLÉS 2009 LIBRO
INGLÉS 0 2.933
INGLÉS 2014 7.786
INGLÉS 2016 1.194
INGLÉS 2008 3.255
INGLÉS 2017 1.925
INGLÉS 2016 6.369
INGLÉS 2011 3.649
INGLÉS 2008 4.159
INGLÉS 2008 3.649

INGLÉS 2017 3.653
INGLÉS 2017 2.302
INGLÉS 2012 3.649
INGLÉS 2014 2.933
INGLÉS 2013 1.194
INGLÉS 2017 11.764
INGLÉS 2016 3.526
INGLÉS 2012 2.981
INGLÉS 2010 0.421
INGLÉS 2018 3.756
INGLÉS 2014 1.194
INGLÉS 2010 3.255
INGLÉS 0 3.048
INGLÉS 2011 2.302

INGLÉS 2017 3.649
INGLÉS 2014 3.255
INGLÉS 2008 4.159
INGLÉS 2010 2.981
INGLÉS 2011 3.255
INGLÉS 2018 3.756
INGLÉS 2016 3.756
INGLÉS 2013 3.649
INGLÉS 2017 3.255
INGLÉS 2011 3.255
INGLÉS 2008 3.649
INGLÉS 2014 2.108
INGLÉS 2017 2.933
INGLÉS 2013 3.649

INGLÉS 2011 3.649
INGLÉS 2013 3.649
INGLÉS 2016 1.194
INGLÉS 2012 2.933
INGLÉS 2014 0.506
INGLÉS 2014 1.96
INGLÉS 2014 0.506
INGLÉS 2014 0.163
INGLÉS 2014 0.506

AUTOR PRINCIPAL ÍNDICE H*
Ramazan Gürkan
María de Lourdes Garzón

S.
María de Lourdes Garzón

Serra
José Pérez Urizar
Jorge Luis Flores-Moreno
Estela Meléndez-
Camargoa
Rodrigo L. Oréfice
K. Basavaiah
Víctor M. Loyola-Vargas
Isabel Andueza
Isabel Andueza
Dary L. MENDOZA M
KARENT BRAVO
Leopoldo Villafuerte
Robles
Mónica Alejandra Boeris
Waldo Argüelles-Monal
Lucila Isabel Castro

Pastrana
Fleming MARTÍNEZ R
Robles
José Carlos Rebuglio

Vellosa
Giovanna R . Almanza
Mauro C. M. Laranjeira
Leopoldo Villafuerte-
Robles
Aracely Evangelina Chávez

Piña
Efrén Hernández Baltazar
Elaine Ojeda Armaignac

Thomas R. F. Scior
T., Pérez Bueno
Yanelis Saucedo-
Hernández
José Julián LÓPEZ G
Fleming Martínez
M. Tubino
Alberto Bencomo-
Martínez
L.M. Melgoza Contreras
Robles
Juan Manuel Urbina-

González
Villafuerte Robles,
Leopoldo
Yolima BAENA A
Suchitil Rivera-Marrero
Angel Guzmán
Teresa Mancilla
José Luis Montiel

Hernández
NA
NA
Jafar Akbari
NA
NA
NA
Nwoko Valentine E
D.V. R. N. Bhikshapathi
Prachi Pandey
V. Hemalatha
Melissa R Cardoz
Bogdan Tita
Nagasree K
Limce Thampi
NA
Srinivasa Reddy Meka
Karrie Marren
bd El-Gawad H. Abd El-

Gawad
Mona Hassan Aburahma
M. L. Vueba
Jaleh Varshosaz
S. A. Botha
Marcello Garcia Trevisan
Kondi Vanitha
Marcelo Antonio de
Oliveira
Julie Fernanda Benavides
Arévalo
Luis Octavio Martínez

Álvarez
Luis Octavio Martínez

Álvarez
Marco Aurélio Lamolha
J.R. González-Escalada
Humberto Gomes Ferraz

DOI
KEY WORD
Catalytic effect; V(V); Kinetic-spectrophotometric method; fixed-time method; Bromate; Ponceau

Xylydine and 5-Sulphosalycilic acid
almidón, chayote, compresión directa, retrogradación,

pregelatinización, proceso hidrotérmico
: almidón, chayote, retrogradado, compactación directa,

amilosa insoluble, tabletas
ketorolaco, tramadol, antinocicepción,

sinergismo.
hidróxido doble laminar; ácido pipemídico; material

híbrido; intercalación; actividad antibacterial.
: Oenothera rosea, Onagraceae, antiinflamatorio,

modelo del granuloma, indometacina
Biopolímeros, sistemas de liberação de fármacos, excipientes, biomateriais.
Ranitidine; assay; silver nitrate; pharmaceuticals; spectrophotometry; titrimetry.
Catharanthus roseus, alcaloide, biosíntesis,

metabolitos secundarios.
Hidroxipropilmetilcelulosa (HPMC), pH, tensión

superficial, película.
Hidroxipropilmetilcelulosa (HPMC), viscosidad,

flujo pseudoplástico.
Ulomoides dermestoides, beetles, metabolites, biological assay, Chorioallantoic Membrane.
NA
Resistencia a la ruptura, Resistencia a la
tensión, Características tecnológicas, Metronidazol,
lubricantes.
:
Salpichroa origanifolia
quitosana, pectina, polisacárido,
Salpichroa origanifolia, complejo
fitofármacos, polielectrolito,
antiinflamatorio, conductimetría
analgésico.
Naproxén, solubilidad, solvatación, termodinámica.
liberación controlada, metronidazol, Carbopol 971P NF, Methocel K4M, tabletas flotantes, bicarbonato de
sodio
cetoprofeno, hemólise, dano oxidativo, radicais livres
Sapogenins, Chenopodium quinoa, acute anti-inflammatory activity, ear edema model, paw edema
model.
Crosslinking, chitosan, diclofenac sodium, microspheres, controlled release
Pelanserina, HPMC, Método de mezclado, Liberación sostenida, Ácido cítrico.
aceite de pescado; indometacina; daño

gástrico; in amación.
microondas, síntesis asistida por microondas, calentamiento dieléctrico
corrosión, inhibidores, petróleo, refinación, destilación atmosférica

Ageratina glabrata, extracto, ratas, analgesia
mulsión oleosa, estabilidad
Parthenium hysterophorus L., preformulación, polvo, contenido de humedad, higroscopicidad,

propiedades de flujo.
Ancianos, prescripción potencialmente inadecuada, metodología STOPP, polifarmacia, errores de

medicación.
sulfonamidas2 etanol2 mezclas binarias2 método extendido de solubilidad de Hildebrand2 parámetro de

solubilidad de HildebrandP
vancomycin; flow injection analysis; spectrophotometry; copper (II) ions
Alzheimer, amiloide, Autodock Vina, QSAR, derivados de naftaleno, Rosetta+, modelos computacionales,
docking, agregados, placas amiloides, interacción.
Comprimidos osmóticos bicompartimentales, Nifedipino, Acetato de Celulosa Butírico, HPMC, Óxido de

Polietileno.
Lactosas, Funcionalidad de los excipientes, Dureza de las tabletas, Resistencia a la tensión de las tabletas,
Compactabilidad, Amoxicilina, Captopril.
:∆α,β -butenolidas, furan-2[5H]-onas
excipientes, genéricos, funcionalidad, características físicas, características tecnológicas.
Complejo, polimetilmetacrilato, diclofenac, solubilidad, par iónico.
derivados del naftaleno, placas seniles, enfermedad de Alzheimer, fármacos antiinflamatorios no

esteroidales, SPECT.
ciclooxigenasa, drogas antiinflamatorias, naproxen, celecoxib, síntesis.

Isoindolinas, Docking, ciclooxigenasa, anti-inflamatorios, analgésicos, amino ácidos
artritis reumatoide, tratamiento, in_x001F_amación, fármaco, CAMs
Tablet, piroxicam, stability, compatibility
Formulation; Evaluation; Lansoprazole; Enteric Coated Pellets
Piroxicam; Capsules; Croscarmellose sodium; In vitro dissolution; Similarity factors
Misoprostol; Bioavaialbility; Sodium CMC; Korsmeyer peppas; Mucoadhesive microspheres.
Nanocarrier, Arthritis, Transdermal drug delivery, Permeation, NSAID
Naproxen, Pantoprazole, Delayed release, Multi-layered tablets
Pediatrics, bitter taste, oral medicated jellies, natural polymers, ranitidine hydrochloride
Acetylsalicylic acid Excipient Compatibility study TG/DTG/DSC FT-IR X-ray

Gemifloxacin mesylate, HPMC, gum kondagogu, floating microspheres.
Compatibility; DSC; Etodolac; Excipients; Solid dispersions.
calorimetria exploratória diferencial, métodos termo-analíticos, estudo de compatibilidade

fármaco/adjuvante, comportamento térmico, isoniazida, adjuvantes tecnológicos primários, formas
farmacêuticas sólidas, agregação por via úmida, processo de compactação
Ibuprofen, Ketoprofen, DSC, Cellulose ether derivatives, Drug-polymer interaction, Thermal analysis
enteric-coated pellets, aceclofenac, eudragit L100-55, NSAID, multiparticles
bioavailability, biodegradation, formulation, liposome, nanoparticle, nephrotoxicity, NSAIDs, polymer
Ketoprofen, cellulose ether polymers, polymer mixture, drug release, matrix tablets, Raman spectroscopy,
scanning electron microscopy, XRPD
amorphous, drug-excipient interaction, gastrointestinal transit, oral absorption, poorly water-soluble

drugs, solid dispersion
acid base interaction, drug excipient compatibility, pHmax, Salt disproportionation, salt formation
hydroxypropyl methylcellulose, mannitol, microcrystalline cellulose, near infrared chemical imaging,
Pregabalin-acetaminophen combination, thermal analysis
DSC, Fluvoxamine, Incompatibility, Kinetic, Lactose
drug release, gastroretentive, mucoadhesion, quality by design, x-ray imaging

Bioadhesion, Central composite design, Controlled release, Domperidone, EVIV correlation, Ex vivo
permeation, Hot-melt extrusion, In vitro dissolution
Cashew gum, Colonic drug delivery, Direct compression, In vitro release10/01/2018 Matrix tablets, Xanthan
gum
Drug-excipient interactions, Impurities, Olanzapine, Polymorphism, Stress testing
Ceftriaxon, Chitosan, DGA, FTIR
DSC, Excipients, FTIR, Memantine
Carbopol, Ethyl cellulose, Films, HPMC, Ketorolac tromethamine, Ocular, Ofloxacin, PVPK30
Drug stability, Drug-excipient interaction, Spectroscopy, Thermal analysis
Compatibility study, Curcumin, Piperine, Polymeric nanoparticles, Quercetin, Silibinin

drug-excipient interaction, excipients, HPLC (high-performance/pressure liquid chromatography), kinetics,
mass spectrometry, stability
CAP, Emulsification-solvent evaporation, Gemifloxacin, HPMC, Microcapsules, Span 60, Sustained release
β-Cyclodextrin, Implants, Paclitaxel (PTX), Poly(ε-caprolactone)
Capsules, Compatibility, Degradation, Dissolution, Excipients, Granules, Impurities, Mechanism, Reaction,

Stability, Tablets
Compatibility, Floating drug delivery system (FDDS), Floating duration (FD), Floating lag time (FLT),
Scanning electron microscopy (SEM)
Drug - excipient incompatibility, Hot-melt extrusion, Hydroxypropyl methylcellulose acetate succinate

(HPMC-AS), Solid dispersion, Succinic acid
ASTM E698, comparative stability, decomposition, isoconversional kinetic study, perindopril erbumine,
perindopril tert-butylamine, pharmaceutical formulation, thermal stability
Effervescent formulations, Hair follicles,Minoxidil, Preformulation, Skin permeation

HET-CAM, In vitro in vivo correlation, Lyophilized polymer matrix, Ocular delivery, Timolol maleate
Nanostructured lipid carrier, Preformulation, Solubility, Stability, Tamoxifen

Corneal wound healing, In situ gel ocular films, Naltrexone hydrochloride, Plasticisers, Polymers
Contraceptive, controlled release, non-steroidal, ormeloxifene
In vivo study, Permeation studies, Sertraline, Transdermal,Transfersomes

Benznidazole, Chagas disease, disintegrating agent, dissolution, mixture design, pellets
Many women experience perineal pain after childbirth, especially

after having sustained perineal trauma. Perineal pain-management strategies are
thus an important part of postnatal care. Non-steroidal anti-inflammatory drugs
(NSAIDs) are a commonly used type of medication in the management of postpartum
pain and their effectiveness and safety should be assessed. OBJECTIVES: To
determine the effectiveness of a single dose of an oral NSAID for relief of acute
perineal pain in the early postpartum period. SEARCH METHODS: We searched the
Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2016),
OpenSIGLE, ProQuest Dissertations and Theses, the ISRCTN Registry and
ClinicalTrials.gov (31 March 2016). We also reviewed reference lists of retrieved
papers and contacted experts in the field. SELECTION CRITERIA: Randomised
controlled trials (RCTs) assessing a single dose of a NSAID versus a single dose
of placebo, paracetamol or another NSAID for women with perineal pain in the
early postpartum period. Quasi-RCTs and cross-over trials were excluded. DATA
COLLECTION AND ANALYSIS: Two review authors (FW and VS) independently assessed
all identified papers for inclusion and risk of bias. Any discrepancies were
resolved through discussion and consensus. Data extraction, including
calculations of pain relief scores, was also conducted independently by two
review authors and checked for accuracy. MAIN RESULTS: We included 28 studies
that examined 13 different NSAIDs and involved 4181 women (none of whom were
breastfeeding). Studies were published between 1967 and 2013, with the majority
published in the 1980s. Of the 4181 women involved in the studies, 2642 received
a NSAID and 1539 received placebo or paracetamol. Risk of bias was generally
unclear due to poor reporting, but in most studies the participants and personnel
were blinded, outcome data were complete and the outcomes that were specified in
the methods section were reported.None of the included studies reported on any of
this review's secondary outcomes: prolonged hospitalisation or re-hospitalisation
due to perineal pain; breastfeeding (fully or mixed) at discharge; breastfeeding
(fully or mixed) at six weeks; perineal pain at six weeks; maternal views;
postpartum depression; instrumental measures of disability due to perineal pain.
NSAID versus placeboCompared to women who received a placebo, more women who
received a single dose NSAID achieved adequate pain relief at four hours (risk
ratio (RR)
Aminated 1.91,Curcumin,
starch, 95% confidence interval (CI)
Drug delivery, Iron1.64 to 2.23,
oxide, 10 studies, 1573
Nanoparticle
participants (low-quality evidence)) and adequate pain relief at six hours (RR
1.92, 95% CI 1.69 to 2.17, 17 studies, 2079 participants (very low-quality
evidence)). Women who received a NSAID were also less likely to need additional
analgesia compared to women who received placebo at four hours (RR 0.39, 95% CI
0.26 to 0.58, four studies, 486 participants (low-quality evidence)) and at six
hours after initial administration (RR 0.32, 95% CI 0.26 to 0.40, 10 studies,
1012 participants (low-quality evidence)). Fourteen maternal adverse effects were
reported in the NSAID group (drowsiness (5), abdominal discomfort (2), weakness
(1), dizziness (2), headache (2), moderate epigastralgia (1), not specified (1))
and eight in the placebo group (drowsiness (2), light headed (1), nausea (1),
backache (1), dizziness (1), epigastric pain (1), not specified (1)), although
not all studies assessed adverse effects. There was no difference in overall
maternal adverse effects between NSAIDs and placebo at six hours
post-administration (RR 1.38, 95% CI 0.71 to 2.70, 13 studies, 1388 participants
(very low-quality evidence)). One small study (with two treatment arms) assessed
maternal adverse effects at four hours post-administration, but there were no
maternal adverse effects observed (one study, 90 participants (low-quality
evidence)). Neonatal adverse effects were not assessed in any of the included
studies. NSAID versus paracetamolNSAIDs versus paracetamol were also more
Ferulic acid, Laser speckle contrast imaging, Microdialysis, Pharmacokinetics, Tetramethylpyrazine, UPLC-
MS/MS
anti-inflammatory, patch, phospholipid complex, phytosome®, resveratrol
Hydrophilic interaction chromatography, Mixed-mode chromatography, Reversed phase liquid

chromatography, Two-dimensional liquid chromatography on the single column
Biotechnology, Blood compatibility, Colloids, Nanoparticle, Surface modification, Anti-Inflammatory

Agents, Non-Steroidal
Analgesics, Opioid
formulation, microdialysis, permeability, skin, transdermal
Anti-Inflammatory Agents, Non-Steroidal,
Analgesics, Opioid, Tramadol
Anti-Inflammatory Agents, Non-Steroidal
Drug Incompatibility, Tramadol
Acetaminophen, Ketamine, Nefopam, Solutions

Anti-Inflammatory Agents, Non-Steroidal, Curcumin
Drug Stability, Piroxicam
Analgesics, Ketamine, Methadone, Narcotics, Pyrrolidines, Tramadol
Aspirin, Calorimetry, Differential Scanning, Drug Incompatibility,

crystal structure; X-ray powder diffractometry; thermal analysis; solid state; hydrates/solvates
Triamcinolone; PLGA microparticles; Spray drying; Thermal analysis; X-ray analysis; Thermal stability
Stability; Enalapril; Pharmaceutical dosage forms; Drug release
Imidazolidine; Indomethacin; Anti-inflammatory; Analgesic
Polymeric micelles; Solubilization; In vitro release; Hemocompatibility; Cytotoxicity

Transdermal self-adhesive films; Anti-inflammatory drugs; Tenoxicam; Skin biopsy
Drug–excipient interaction; Thermal analysis; Spectroscopy; Drug stability
ophthalmic drug delivery; nanotechnology; nanoparticles; lipids; liposomes; permeation; cell uptake; ELISA;
confocal microscopy; computational modeling
Adjuvant arthritis; Anti-inflammatory activity; Carbopol 940; Emulgel; Inflammation; Poor solubility
Compatibility; Microcrystalline cellulose; Diclofenac potassium; Pellets; Stability
Meloxicam; Oral lyophilisates; Matrix forming agent; Galactomannan; Lyophilization
poloxamer gels; hot-melt extrusion; ex-vivo permeation study; rheology study; in-vitro release study
Hydroxypropyl-beta-cyclodextrin (HPβCD); Indomethacin (IMC); α-tocopherol (Vit. E); Lauryl

Isoquinolinium Bromide (LIB); Cosmetology; Zeta CAD; Double emulsion-solvent evaporation; Eudragit®
RS100; Anti-inflammation; Antioxidant; Anti-hair growth
Self-assembled hydrogel; Anti-inflammatory; Ocular drug delivery; Endotoxin induced uveitis
Nasal administration; Analgesics; Calu-3; Permeability; Meloxicam; Pharmacokinetics
Aceclofenac; Chitosan; Crystals; Sodium citrate; Dissolution; Pharmacokinetics; Pharmacodynamics

Arthritis; Diclofenac diethylamine; Drug delivery; Extended release;Microsponges
Hydrogel-thickened microemulsions; Xanthan gum; Ibuprofen; In vitro drug release; Analgesic effect;
Antiinflammatory activity
Ibuprofen–Diethylaminoethyl Dextran conjugates; In situ granulation-crystallization; Temperature

quenching; Crystanules; Crystal habit, Micromeritics
PLGA; SFEE; Ketoprofen Solid solubility; Supercritical
Flurbiprofen; PVP VA64; solid dispersion; hot melt extrusion; osmotic pump; central composite design-
response surface methodology
Microneedles; Transdermal; Ibuprofen; Biocompatibility
Preformulation; Solvent casting method; Diclofenac sodium; Ammonio methacrylate copolymer;

Thermoanalysis; Raman spectroscopy
Electrospinning; Drug-loaded nanofibers; Eudragit® L 100-55; Colon-targeted drug delivery
Solid lipid microparticles; Lyophilisation; Ibuprofen; Cryoprotectant
Compatibility; Solid state; High-throughput; Automation;

Acetylsalicylic acid; Hot-melt coating; Glycerin monostearate; Storage stability; Drug/excipient compatibility
Differential Scanning Calorimetry (DSC); Thermogravimetric analysis (TGA); Paracetamol; Chlorpheniramine

maleate and phenylephrine hydrochloride
bioavailability; dissolution rate; excipients; formulation; oral drug delivery; oral absorption;
physicochemical properties; physical stability; tablet; solid dispersion
Glycyrrhetinic acid; Paeoniflorin; Pharmacokinetics; Pharmacodynamics; Analgesic; Transdermal drug

delivery
Lornoxicam; Liposomes; Central Composite Design; Thin film hydration method
Tramadol; Metabolites; Urine; HPLC-FL; HPLC–MS/MS
anti-inflammatory; chitosan; nanocomposite; permeation; polyethylene glycol
Membrane; Buprenorphine HCl; Tween 80; PLGA; In situ forming implant

Atomic layer deposition; Acetaminophen; Drug release; Cytocombatibility; Drug delivery system
Cetirizine; Indomethacin; Polyethylene glycol; Drug–excipient interaction; SFC
THC; Plasticizers; Stability; Hot-melt; Poly (ethylene oxide); Release; Microenvironmental Ph; Prodrug
Ketoprofen; Excipients; Compatibility studies; TG/DTG/DSC
Meloxicam; Thermal analysis; Compatibility; Pharmaceutical formulations
Excipients; Safety; Quality; IPEC; ICH; FDA; SUPAC; Pharmacopoeial considerations; Biowaiver
Epidermal growth factor; Solution stability; Excipients compatibility; Formulation
Drug-excipient compatibility; Mixture design; Thermal analysis
FTIR; Solid-state interaction; Compatibility magnesium stearate
Celecoxib; Nanosturctured lipid carriers (NLC); Topical gels; Micellar; Anti-inflammatory; Prolonged action
Transdermal vector; Curcumin; Encapsulation efficiency; Anti-inflammatory effect

nanoparticles; nanostructured lipid carriers; flurbiprofen; hydrogels; factorial design; drug release;
ophtalmic drug delivery; physical stability; polymorphism; rheology
RESUMEN
A novel sensitive and relatively selective kinetic method is presented for the determination of V(V), based on its catalyt
measuring the decrease in absorbance of Ponceau Xylydine at 640 nm between 0.5 to 7 min (the fixed time method) in
reaction were studied. The method is free from most interferences, especially from large amounts of V(IV). The decrea
3Sblank/k criterion) and a coefficient of variation (CV) of 1.8% (for ten replicate measurement at 95% confidence level). T
mineral water samples and a certified standard reference material such as SRM-1640 with satisfactory results. The vana
Los excipientes
satisfactory. It was para compresión
observed that directa
the results hanof demostrado
the SRM 1640 ser were
muy eficientes, por lo quewith
in good agreement algunos de ellos value.
the certified se han
elaborado a partir de diferentes fuentes de almidón. El almidón extraído de las raíces tuberosas del chayote (Sechium e
puede ser atractivo en aplicaciones farmacéuticas ya que presenta alta viscosidad y mayor proporción de amilosa que o
almidones tradicionales. Con objeto de impartirle propiedades de compactación, fue sometido a un proceso hidrotérm
pregelatinización y retrogradación. En este estudio se reportan los resultados de la caracterización fisicoquímica del alm
los almidones
chayote nativoretrogradados
y retrogradadotienen buenas propiedades
en comparación con almidones de compactación
comerciales.para ser utilizados
Las pruebas en la elaboración
de compactación de
preliminares
tabletas por compresión directa, debido a sus características granulares,
que el almidón de chayote retrogradado tiene un alto potencial como excipiente para compresión directa, pues las tab a la presencia de amilosa insoluble y la alta ca
de hinchamiento de la amilopectina. En este trabajo se estudiaron
elaboradas con dicho producto, presentan características muy superiores a las elaboradas con el Starch 1500. las propiedades de compactación del almidón de ch
retrogradado, en comparación con las del almidón de papa retrogradado y del producto comercial Starch 1500. Los res
mostraron que el almidón de chayote tiene mejores propiedades, ya que da lugar a tabletas más duras, más resistentes
La analgesia
estearato debalanceada
magnesio y se con basa
mayoren lacapacidad
combinación de dos que
de dilución o más analgésicos
el producto y/o vías de
comercial. administración.
Cuando El objetivo
el porcentaje de
de gelatiniz
estudio
del almidón es alto, se modifican los perfiles de liberación de las tabletas, lo que resulta interesante para su aplicaciónee
fue evaluar el tipo y magnitud de interacción analgésica de ketorolaco sistémico (KS) y tramadol local (TL) en
de la formalina
elaboración en ratones.
de formas KS en dosis
de liberación de 0.18, 0.5, 1.8 y 3.2 mg/kg i.m., mientras que TL se administró a dosis de 50, 10
controlada.
400 µg/pata. Se evaluó el efecto antinociceptivo de la combinación KS-TL empleando un esquema de diluciones secuen
a proporción fija. El análisis isobolográfico determinó que existe sinergismo analgésico, es decir que la DE50 experimen
Se preparó el materialmenor
es significativamente híbridoque ácido pipemídico-MgFeAl
la teórica (p<0.05). Los resultados sugieren que esta estrategia terapéutica puede ser
por intercambio
herramienta iónico partiendo
promisoria en el aliviodel delhidróxido
dolor agudo. doble laminar
MgFeAl-Cl, usado como matriz inorgánica receptora. El material hí-
brido obtenido contiene en su región interlaminar aniones del ácido
pipemídico, así como también, en menor medida; iones carbonato y
Oenothera
cloruro querosea no fueron L´ Hér. ex Ait. (Onagraceae)
intercambiados. es comúnmente
Las propiedades conocida como hierba del golpe y utilizada en la medicin
antibacteriales
Mexicana para el tratamiento de padecimientos
contra cepas de E. coli y S. typhi fueron evaluadas mediante el método inflamatorios, renales y bacterianos. El objetivo de este estudio fue
evaluar la actividad antiinflamatoria
de dilución en caldo. La matriz inorgánica de partida MgFeAl-Cl node los extractos acuoso y metanólico de esta planta. Los extractos acuoso (500 mg
peso
presentó corporal (p.c.))
actividad y metanólico
antibacterial (100 mg/kg
alguna; sin embargo,p.c.) de el Oenothera
material híbridorosea fueron evaluados mediante el modelo del gran
en ratas y técnicas
MgFeAl-PIP eliminó histológicas.
la totalidad Ambos extractos de indujeron unadedisminución significativa del proceso inflamatorio en re
Os
con polímeros
los grupos representam
testigo (p<0.05).uma de das
El
las
efecto
colonias
classes E. coli luego
de materiais
antiinflamatorio mais
del versáteis disponíveis para
extracto metanólico aplicações
fue similar em diversas
al efecto de indometacin
90 mininclusive
áreas, de exposición a y presentóPolímeros
farmacêutica. buena actividad naturais, contra
naturais bacterias
modificados e sintéticos são empregados como excipiente
dato fue corroborado
de S. typhi después por
deformulaçãolos resultados histológicos. Ningún extracto
120 min. de cosméticos e medicamentos de liberação convencional e de liberação produjo daño gastrointestinal. La DL50 de los ex
farmacêuticos para a
acuoso y metanólico fue mayor de 40 y 8 g/kg, respectivamente. Estos resultados sugieren que ambos extractos de Oe modificada.
Nos
roseadias atuais, polímeros
produjeron actividadsão desenvolvidosy para
antiinflamatoria fueron atuarem como moduladores
considerados no tóxicos. e direcionadores da liberação de fárma
em sítios específicos no organismo. Polímeros biodegradáveis, bioadesivos, biomiméticos e hidrogéis responsivos têm
Two simple, rapid incluídos
sido amplamente and cost-effective
em formulações methods based on titrimetric
farmacêuticas. Os avanços and spectrophotometric
na idealização de novos Sistemas de Liberação
techniques
de Fármacos somente são e serão permitidos a partir do desenvolvimentoforms
are described for the assay of RNH in bulk drug and in dosage using silver
de polímeros nitrate, mercury(II)thiocya
projetados especificamente pa
and iron(III)nitrate as reagents. In titrimetry, an aqueous solution of
a área farmacêutica. Neste sentido, o presente artigo visa a revisar e apresentar informações sobre o uso de polímeros RNH is treated
with
aplicaçõesmeasured excess of silver
farmacêuticas que poderãonitrate in HNO3
ser úteismedium, followedde
no planejamento bynovos
determination
sistemasof unreacted
com silver superiores.
desempenhos
nitrate by Volhard method using iron(III) alum indicator. Spectrophotometric method involve the addition
Los
a known alcaloides
excess son of uno de los grupos de metabolitos
mercury(II)thiocyanate and iron(III)nitrate to RNH, followed by the measurement
secundarios más diversos
of the absorbance of iron(III)thiocyante encontrados en los organismos
complex at 470 nm. vivos. Este method is applicable over 4-30
Titrimetric
grupo incluye alrededor de 12,000 productos, entre los
mg range and the reaction stoichiometry is found to be 1:1 (RNH: AgNO3). In the spectrophotometric cuales se
encuentran
method, thelos alcaloidesisindólicos,
absorbance found toalcaloides
increase linearlyderivados withdel triptofano of RNH which is corroborated
concentration
que conforman
by hidroxipropilmetilcelulosaalrededor
the correlation coefficient of de la cuarta
0.9959.esTheparte de todos ellos. Los
system obey Beer’s law for 5-70 µg mL-1. The calculated
La
alcaloides se hanabsorptivity
reportado en (HPMC), un coloide
apparent molar
hidrofílico derivado de la andvarias
celulosa sandell
con
familias
grupos
vegetales,
sensitivity valuespero
hidroxipropoxilo
principalmente
are found
y to be 3.27 × 103 L mol-1 cm-1, 0.107
en
µg las Apocinacea,
cm-2 respectively. Loganiaceae
The y Rubiaceae,
limits of detection todas del
and quantification are also reported for the spectrophotometric
metoxilo.
orden Se emplea
Gentianales. en
Entre preparaciones
los alcaloides oftálmicas
más como
importantes viscosantes,
se tiene a los were evaluated as per ICH
method.
en Intra-day
dispersiones and
humectantes inter-day paraprecision
lentes and
de accuracyy of
contacto en the methods
lágrimas
de tipo bisindólico
guidelines. The como la vinblastina, utilizada en el tratamiento del
artificiales.
mal de Se hamethods
Hodgkin, ycomprobado
a la
were successfully
vincristina que una dispersión
empleada
appliedde
en el
to HPMC
the assay
tratamiento alde2%ofla
RNH in formulations and the results
Se
4000 ha comprobado
were compared
cps con éstaswith que una
características dispersión
those of a reference no de
producehidroxipropilmetilcelulosa
method by applying
inflamación, es Student’s t and F-tests. No interference was
tolerada
leucemia;
(HPMC) además deinflamación,
los pharmaceutical
alcaloides esmonoterpén-indólicos ajmalicina
observed
por el ojonofrom
ybyserpentina
produce
humano common
utilizados y es como
capaz agentes
de cubrir tolerada por el ojo
el excipients.
contenido
antihipertensivos
The accuracy
intraocular.
contra lasEnof the methods was further ascertained
humano
este performingy
trabajo es secapaz
recoveryde
evaluaron cubrir
tests el contenido
by standard
dispersiones de intraocular.
addition
HPMC al Es
method.
2% 4000 empleada
cps, en en
arritmias cardiacas
preparaciones y el mejoramiento
oftálmicas como de la circulación
hidrocoloide viscosante, cerebral.
en La
dispersiones
agua,
complejidadcon cada una
decontacto de las siguientes
los procesos genéticos, sales: cloruro ydedesodio
catalíticos 0.059%,en
transporte
para
cloruro lentes
de de
potasio 0.075%, y lágrimas
cloruro artificiales
de calcio como humectante
0.048%, cloruro de magnesio
In
yla traditional
biosíntesis
como medicine
de los alcaloides
viscoelástico of Central
en 0.39%, and
monoterpén
la extracción South America, the
indólicos,deescatarata
extracapsular tenebrionid
actualmente beetle Ulomoides
0.03%, acetato
dermestoides
uno implantación de
is sodio
used
de los retos intelectuales as an a citrato
phrodisiac, de
más estimulantes sodio
for the 0.17%.
treatment
en el al Mezcla
área of
dequeinflammatory
los metabolitos diseases and cancer. Recently was
con
de todas las sales de
y conlente intraocular.
solución de En Venezuela,
Ringer Lactato, en igual
cuanto a en
pH,
reported
secundarios.
otros países,cytotoxic
Si
sebien and
emplean genotoxic
se requieren
sustancias properties
más of non-polar
de 50 pasos metabólicos
viscoelásticas, extract of U. dermestoides; also anti-inflammatory
tensión
and
para superficial
immunomodulatory
sintetizar los y características
alcaloides activitymás of de la película
aqueous
importantes whole seconsiguiéndose
refiere.
body
producidos El pH
extract
por C. deen
of beetle was reported, it suggests the existence
el
lasmercado
dispersiones productosisotónicas importados
obtenidas, a elevados
se costos.dentro
encuentran Esta contribución,
del rango
of components
roseus,
permitirá hasta with potential
ahora solamente
promover el desarrollo pharmacology
sede han undeterminado
producto use. On the other
y caracterizado, en
oftálmico hand, it is necessary to identify those
NA
fisiológico
polar and establecido
non-polar por
extracts la USP
of U. XXIII para
dermestoides dispersiones
with de HPMC
anti-irritant properties for the membranes and blood
algún grado,
nacional, como 20 alternativa
de las enzimas pararequeridas.
ela uso Faltan aún
en pacientes depor elucidar
escasos un
recursos
de uso
vessels, oftalmológico.
which
importante número will be En
used
de pasos cuanto
in las
subsequence películas formadas,
biological test éstas
and se
clinical assays. Objectives: The purpose of
económicos.
ven favorecidas La evaluación
por la presencia delmetabólicos,
comportamiento
de sales
para después
ycomposition
presentan reológico purificar
variación en
las
de dispersiones
la and hexanic extracts of U. dermestoides,
this
de research
correspondientes
HPMC was to identify
enzimas e the chemical
intentar
al 2% 4000 cps, en agua, con cada una de las clonar sus genes. of methanolic
También es
tensión
and superficial.
to assess their anti-irritant capacity.
necesario
siguientes elucidar
sales: los
cloruro diversos
de sodio 0.069%,Methods:
aspectos de The
la regulación
cloruro de extracts
potasio were obtained from adult beetles of
de la0.075%,
biosíntesis
U. dermestoides.
de los alcaloides,
cloruro de calcio 0.048%,The chemical
tanto encloruro composition
el nivelde celular
magnesio of
como0.03%, the extracts
acetato de determined by gas chromatography-mass
en el molecular, was
spectrometry
pero sobre
sodio 0.39%,todo (GC-MS)
citrato determinar and
de sodio cual the anti-irritant
0.17%. esMezclas
su función effect
de entodasof each
las las extract
plantas
sales que
y con was
los evaluated by means of a modified
assay
soluciones de Ringer Lactato, se realizó a las 24 h de haber preparado chicken eggs (HET-CAM); the
producen. of irritation
En esta of the
revisión chorioallantoic
se presenta membrane
un análisis (CAM)
del estado of fertilized
actual
results
las wereelexpressed
quedispersiones
guarda conocimiento as irritation
en un viscosímetro en las rutas index de
rotacional (IR). Results:
biosíntesis
tipo Sixlos
de
Brookfield common
R.V.T, compounds were identified in both
alcaloides
extracts: limonene,
monoterpén-indólicos
con aguja Nº 4, expresando myristic,
en C. los palmitic,
roseus estearic, oleic,
resultados en centipoises. Todas las and linoleic fatty acids. But in the alone methanolic
extract were found: 1-pentadecanol, alpha-pinene,
dispersiones presentaron flujo pseudoplástico, acorde con el reportado beta-phellandrene and alpha-terpinene, whereas in the
hexanic extract were found: 2-methyl-p-benzoquinone, 2,4-dihidroxy-1-ethylbenzene, 2,5-dimethylquinone,
Los valores especí cos de las propiedades tecnológicas permiten establecer parámetros estadísticos y límites para el us
de los excipientes. El propósito del trabajo es la evaluación de la compactabilidad de GalenIQ 720 como excipiente para
compresión directa. El excipiente se valora individualmente y en mezclas con metronidazol y con estearato de magnes
comparándose contra Helmcel 200. Los parámetros determinados son curvas de compactabilidad utilizando la
resistencia a la ruptura y resistencia a la tensión. La compactabilidad de Helmcel 200 es 2-3 veces mayor que la de Galen
Los
720.analgésicos
Sin embargo, y los antiinflamatorios
GalenIQ 720 muestrano unaesteroides
mejoría de sonla de uso frecuente en
compactabilidad en medicina
mezclas con un lubricante, contra la
veterinaria. Las drogas comerciales utilizadas actualmente
conocida pérdida de compactabilidad de la celulosa microcristalina. La mejora son efectivas en procesos
de unaagudos.
característica del fármaco, por un
Pero cuando se administran durante largos
excipiente, puede ser usada como parámetro de funcionalidad. períodos de tiempo para tratar enfermedades
crónicas, su empleo suele estar limitado por la presencia de efectos secundarios o por el alto
costo del tratamiento. En nuestro laboratorio se investigaron los efectos antiinflamatorio y
Se realizó elde
analgésico estudio
la (n.v.de la reacción
huevito interpolimérica
de gallo), una planta entre nativados de la polielectrolitos
región naturales: la quitosana, polisacárido
catiónico y la pectina, polisacárido de naturaleza aniónica.
pampeana de Argentina. Antedecentes etnobotánicos orientaron estudios iniciales llevados La reacción intepolielectrolítica seasiguió a través
de la variación de la conductividad de una disolución de
cabo en ratones que confirmaron la presencia de actividad antiinflamatoria en el extractopectina (2,03 · 10-4 equiv · L-1) resultante de la adición de una
disolución de hidrocloruro de quitosana (3,55 · 10-3 equiv
hidroalcohólico crudo, obtenido de partes aéreas desecadas de la planta. Este extracto fue · L-1) debido a la formación del complejo polielectrolito (CPE)
aparición de una ligera turbidez en la disolución durante la
sometido a procesos de purificación obteniéndose distintas fracciones que fueron llevadas a titración evidenció la formación del CPE insoluble. El cambio
de pendiente de la curva de titración después
sequedad. El polvo de , logrado luego de una extracción metanólica, del punto de equivalencia indica que se ha completado la reacción interp
De esta forma, se pudo determinar la estequiometria del
mostró el mayor efecto antiinflamatorio en ratones utilizando el test de la carragenina. complejo, Z ([Quitosana]/[Pectina]), que resultó
Z = 0,89. La
También extensión
se evaluó de la reacción
la toxicidad o grado de
determinando que acomplejamiento,
la administraciónθ,prolongada fue evaluado noen función de la relación [Quitosana
produce
[Pectina]
lesiones gástricas ni alteraciones histopatológicas en estómago, hígado, riñón y cerebro.el elevado grado de cooperativ
y se mantuvo cerca de la unidad en todo el intervalo estudiado, evidenciando
de la reacción.
Evaluando El mayor grado
la importancia de estosde acomplejamiento se obtuvo con lasfarmacológico
resultados en el comportamiento primeras adiciones del hidrocloruro de quitosana
del Polvo,
la disolución de pectinato de sodio (θ = 0,98 a Z = 0,24). A
se comparó el efecto antiinflamatorio del extracto con los AINEs más usados en la práctica partir de entonces, θ decreció hasta un valor mínimo (θ = 0,9
aveterinaria
Z ≈ 0,6, para incrementar nuevamente hasta casi la unidad (θ
para determinar su potencial empleo como fitofármaco. Utilizando el test de la = 0,99) a Z = 0,83.
carragenina en ratones, se determinó a las 5 horas pos administración una reducción del edema
plantar
El naproxén respecto(NAP) al es
grupo control del 49 % con
un anti-inflamatorio polvo de ,de
no esteroidal delamplio
44 % con uso en la actualidad; sin embargo, sus propiedades fi
ácido acetil salicílico (ASA) y del 67 % con fenilbutazona,
de algunos solventes orgánicos en saturación acuosa sobre las funciones siendo de un 59 %termodinámicas
para la de solución del NAP a pH fisi
indometacina,
entalpía considerada
y entropía, para loslaprocesos
droga dedereferencia
solución yendelasolvatación
investigación delde NAP antiinflamatorios.
en tres medios acuosos El a pH 7,4 y saturado
efecto analgésico
presentados se evaluóenutilizando
previamente la literatura.el test de las contorsiones
La solubilidad del NAP ainducidas
25,0 °C sepor ácido acético
incrementa en el siguiente orden: W(ROH)
en
de ratones.
solvatación La disminución
presentan valores en el número
negativos de encontorsiones
todos los casos. con polvo fue del 49%,
Los resultados sesuperior
discutenaen la términos de interaccione
se estudió la disolución
fenilbutazona de metronidazol
(41 %) y comparable (150 mg) ydesde
al ketoprofeno ASA (54%matrices
y52 %).flotantes
Se concluyede liberación
que el controlada, variando su propo
mientras
polvo tiene que unlas matrices
efecto de Carbopol comparable
antiinflamatorio flotaron desde algunos
al ASA. minutos
El efecto del hasta
polvo 4tienehoras.unComo es sabido, la hidratación d
volumen
período de acción más prolongado que la fenilbutazona y como analgésico es superior acon
de hidratación y una disolución más rápida del metronidazol, en comparación la las matrices de Carbopol. E
cuando
fenilbutazonase utiliza la ecuación:menor
y ligeramente Mt /Minf que= el
k *ketoprofeno.
t n . Las matrices Teniendode Carbopol
en cuenta muestran
que en estosuna penetración más rápida y com
.estudios
El efectoelde las burbujas
polvo de no de gasevidencias
mostró es atribuido de atoxicidad
la expansióny que de la matriz y a la obstrucción del área disponible para la d
Os radicais livres são espécies altamente reativas geradas nosposee
organismos vivos com a finalidade
una acción antiinflamatoria
de proteção. Porém, em algumas y analgésica comparable
circunstâncias, estes consão AINES como el ASA
responsáveis pela resultaría
ocorrência ou o
interesante
agravo realizar
de danos en el futuro
teciduais. Muitos estudios clínicos paraapresentam
antiinflamatórios determinaração la utilidad
diretade esteradicais
sobre extracto livres e espécies reativas nã
como fitofármaco
cetoprofeno é um antiinflamatório não esteroidal que gera radicais livres ao sofrer fotoirradiação
e tem com isso um efeito hemolítico importante. A complexação de metais a diferentes fármacos
A
tem partir
sidode residuos
utilizada comode quinua
estratégiareal (Chenopodium
para melhorar aquinoa Willd) se obtuvo
ação farmacológica un extractomoléculas
de diferentes de sapogeninas
e el cual fue
analizado por cromatografía HPLC, además de otros métodos
reduzir seus efeitos colaterais. Neste trabalho são apresentados resultados do estudo de ação do cromatográficos y espectroscópicos, determinándose 4
constituyentes mayoritarios: ácido oleanólico 1, oleanato
cetoprofeno e seus complexos de cério e cobre sobre radicais livres e sobre eritrócitos. de metilo 2, hederagenina 3 y ácido fitolaccagenico 4. La
actividad
Observou-se antiinflamatoria aguda fueasevaluada
que o cério intensifica propriedades mediante dos modelos
scavenger animales, sobre
do cetoprofeno modelo de edema de oreja de ratón
radicais
inducido por aceite de croton y edema de pata inducido por carragenina, determinándose que el extracto muestra una
:livres enquanto
In this
actividad work o cobre
chitosan
antiinflamatoria
intensifica aswere
microspheres
significativa
açõesprepared
en el
sobre oxidantes
modelo by the
de edema
não radicalares.
simple
de coacervation
oreja, mayor
O cobre
method
que los
ainda
and crosslinked
compuestos, using un
sugiriendo
reduziu o efeitoorhemolítico
epichlorhydrin glutaraldehydeapresentado
for the pelo cetoprofeno
controlled release eofmantido
diclofenac pelosodium.
seu derivado
The de cério.
effects of the crosslinking agents
efecto sinérgico entre ellos; mientras que en el modelo de edema de pata se observa una actividad antiinflamatoria
on chitosan microspheres over a 12-hour period were assessed with
significativa en los compuestos aislados y solo una actividad antiinflamatoria moderada en el extracto. regard to swelling, hydrolysis, porosity, crosslinkin
impregnation of diclofenac sodium (DS), and consequently to the release of DS in buffer solutions, simulating the
gastrointestinal tract. The degree of swelling varied with the pH for glutaraldehyde chitosan microspheres (GCM) and
Matrices con cantidades
epichlorhydrin variables de ácido
chitosan microspheres (ECM). cítrico,
Partial obtenidas
acid and por basicgranulación
hydrolysis húmedaaffected ythe aplicando
swellingelbehavior
modelo:of Mtthe
/ Minf
seco (mezclado por volteo), kprom. = 0.185 y nprom. = 0.606. Esto indica
GCM matrix. Release kinetics of diclofenac sodium from these matrices were investigated at pH 1.2, 6.8 and 9.0, una mayor tendencia hacia un mecanismo co
ácido cítrico.
simulating the gastrointestinal tract conditions. The results indicated that the release mechanism deviated slightly from
Fickian transport.
El efecto gastroprotector del aceite de pescado se ha identi cado en diversos estudios. Sin embargo, su mecanismo de
acción no ha sido completamente dilucidado. El objetivo de este trabajo fue evaluar el mecanismo gastroprotector del
aceite de pescado en el daño gástrico generado por indometacina y estudiar si existe modi cación del efecto
anti-in amatorio de indometacina. El aceite de pescado previno las lesiones gástricas inducidas por indometacina, no
revirtió la inhibición de PGE2 pero si bloqueó parcialmente el incremento de LTB4 inducido por indometacina. El aceite
Las aplicaciones
pescado suma sude las microondas
efecto anti-in amatorioestán acreciendo en el área farmacéutica. Este trabajo describe las microondas y los
la indometacina.
reacción,
Nuestros resultados sugieren que una disminución en el
provocando que muchos químicos cambien loscalentamiento
niveles gástricos tradicional
de LTB4por está lasinvolucrada
microondas. enSe el menciona
mecanismo el s
modi_x001F_cada
gastroprotector del aceite de pescado en el daño gástrico generado por indometacina. Además, la administración de e
y dispersiones solidas. Se plantean algunas aplicaciones particulares del empleo de las microondas
aceite de pescado suma su efecto anti-in amatorio a la indometacina.
El presente trabajo se realizó en la Refinería “Hermanos Díaz” de la ciudad de Santiago de Cuba, como parte de una inv
columna de destilación atmosférica de la Combinada No 2, y evaluar los inhibidores Corromin E2 y Chemadd H810F com
de la corrosión por el alto contenido de azufre y de sales que posee el crudo cubano. Se utilizó el método gravimétrico
corrosión sin inhibidor y con el caen en el rango de estabilidad, y de utilizarse el inhibidor sería con a menor concentrac
uestro país, por lo que se han tenido que acometer uivalente, en seis veces durante el período 1991-2000, conllevó al in
eficiencia de los mismos a las condiciones de trabajo. En los experimentos realizados a escala industrial con los inhibido
08X13, manteniendo sus velocidades de corrosión en el rango de estabilida ad para el acero al carbono, ya que no llevó
estabilidad y con eficiencias mayores del 90%. el i ibidor Chemadd H810F también se estudiaron a escala industrial, los m
de l inhibidor, pues aunque sus eficiencias fueron altas las veloc rango de estabilidad disminuida. Los resultados obteni
también se c acero 08X13, acero 12x18H10M2 y el monel, siendo el material de mejor comportamiento el acero 12X18H10
Ageratina glabrata está ampliamente distribuida en México y es conocida popularmente por sus efectos analgésicos. A
A.glabrata en dos modelos térmicos de dolor agudo en rata: la prueba del plato caliente y en la prueba de retirada de la
muestran que el extracto de hoja de A. glabrata posee efecto analgésico 5 horas posteriores a la administración en la p
Se produjeron y evaluaron lotes a escala de banco, de una emulsión oleosa compuesta por células inactivas de Mycopla
conservada en refrigeración de 2-8 °C.
Parthenium hysterophorus L. (escoba amarga) es una planta medicinal de uso tradicional como antiparasitaria. Esta ac
subdesarrollados. No se ha descrito hasta el presente en las Farmacopeas, un ingrediente farmacéutico activo, ni se ha
polvo de la planta para su manufactura a escala industrial. En la investigación fueron evaluadas algunas propiedades de
equilibrio, dinámica de adsorcióndesorción), la distribución del tamaño de partícula, propiedades de flujo (ángulo de re
es ligeramente higroscópico y posee críticas propiedades de flujo. Teniendo en cuenta las propiedades tecnológicas cr
Los pacientes geriátricos representan un reto importante para la prescripción apropiada porque tienen cambios signifi
con el número de fármacos, demostrando que las personas mayores de 65 años tienen mayor riesgo de sufrir un error
institucional basada en los resultados de la aplicación de los criterios de evaluación de prescripción potencialmente ina
frecuencia de prescripciones inadecuadas en 300 pacientes mayores de 65 años y con un consumo de más de 5 medica
medicamentos, indicación, posología, duplicidad terapéutica, interacciones, contraindicaciones, entre otros. Los criter
Se aplicó el Método
terapéutica Txtendido
y medicamentos depuedan
que Solubilidad de Hildebrand
representar 6MTSHv
un riesgo al estudio
en adultos de lapor
mayores solubilidad
presentar decambios
sulfadiazina2 sulfam
en su farma
compuestosP Se obtuvo una adecuada capacidad predictiva del MTSH 6con desviaciones promedio menores del N2Fg
cada una de las historias clínicas, se encontró que el 50,7% (152) de la población del estudio tenía al menos una prescrip
predictivo del MTSH fue de magnitud semejante al que se obtuvo calculando esta propiedad directamente2
Conclusiones: Se encontró que la mitad de las recetas tienen al menos un criterio de prescripción inadecuado, siendodonde se eu
ancianos con todos los detalles de esta institución.
A flow injection method for the quantitative analysis of vancomycin hydrochloride, C66H75Cl2N9O24.HCl (HVCM), bas
limit was estimated to be about 8.5×10-5 mol L-1; the quantitation limit is about 2.5×10-4 mol L-1 and about 30 determin
compared with those obtained with the batch spectrophotometric and with the HPLC methods. Statistical comparison
which present similar precision (RSD: 2.1 % vs. 1.9%).
La enfermedad de Alzheimer (EA) es un desorden neurodegenerativo caracterizado por la acumulación de placas amilo
amiloide (Aβ) desempeña un papel esencial en el desarrollo de la enfermedad, por lo que el estudio de las interaccione
trabajo se utilizaron técnicas de acoplamiento (Autodock Vina), para identificar y caracterizar sitios potenciales de inte
(Quantitative structure–activity relationship) (I) y otra diseñada y sintetizada en el laboratorio (II). Las simulaciones fue
afinidad entre la estructura reportada del Aβ y los pentapéptidos GVVIA y RVVIA. Los resultados sugieren que estos com
En el presente trabajo
proteína-proteína se elaboraron
(Rosetta+) dos formulaciones
el complejo formado por dos de comprimidos osmóticos bicompartimentales de nifedipino v
péptidos Aβ. Tod
los comprimidos se les aplicó un recubrimiento estético para evaluar su in_x001E_uencia en la liberación. Se realizó la p
parámetro marcado en la USP 33 para la prueba de disolución a las 13 horas (F1, 66.10% y F2, 76.01%). Los comprimidos c
Este estudio explora la compactabilidad de SuperTab 24AN, comparada contra SuperTab 21AN, Lactopress anhidra y la
diferente. Sin embargo, con 2% de ácido esteárico es mayor la compactibilidad de SuperTab 24AN (D162 = 231 N) seguid
manteniendo el orden observado con anterioridad. Además, muestra también un efecto igualatorio; la ventaja de un e
El estudio de los sistemas heterocíclicos constituye una de las áreas más versátiles e importantes de la química orgánic
que algunos de estos derivados han exhibido una importante bioactividad. En esta revisión se presenta un breve comp
nuevos medicamentos.
El propósito de este trabajo es una breve revisión y evaluación de la información relativa a los conceptos de funcionalid
mezcla de polvos en una formulación, permite la reducción de las propiedades de los polvos a números tangibles. Los v
utilizarlos, para controlar la calidad y la consistencia entre los diferentes lotes del material y para predecir y comparar l
debido al conocimiento de lo que se puede esperar de un material con cierta funcionalidad
La interacción ácido-base entre un polielectrolito y un fármaco ionizable podría conllevar a la formación de complejos i
estabilidad y del comportamiento de liberación del fármaco, entre otras. Este estudio se realizó para establecer si la so
del solvente; se caracterizaron al estado sólido por espectroscopía infrarroja y difracción de rayos X y se les determinó
fueron 431 y 1498 veces más altos para los complejos EuD50Cl25 y EuD50Cl35, respectivamente, cuando se empleó el a
a la del fármaco original, con potencial aplicación en el diseño de formas farmacéuticas líquidas homogéneas.
La enfermedad de Alzheimer (EA) constituye la causa más frecuente de demencia para la cual no existe cura hasta el m
mortem. Recientemente, se evalúan métodos no invasivos para el diagnóstico in vivo de la enfermedad, mediante técn
Resonance Imaging). En el caso de la técnica SPECT, son descritos nuevos compuestos orgánicos marcados con los rad
de padecer la EA. De ahí que en los últimos años, se haya incrementado la búsqueda de compuestos con estructura sim
agentes quelatantes del 99mTc, para la detección de placas β-amiloides presentes en la EA. Para ello, mediante diversa
Se sintetizaron siete
estructuralmente porcompuestos
medio de lascomo drogas potencialmente
espectroscopias IR, RMN-1 Hanti-inflamatorias, inhibidores
y -13C y espectrometría selectivos de la enzima c
de masas.
celecoxib.
Este trabajo describe un estudio teórico de dos series de isoindolines 1(a-h) y 2(a-h) como posibles inhibidores de COX-
ibuprofeno 6 y dihirodimetilbenzofurano 7, los cuales son bien conocidos como antiinflamatorios. Los compuestos 6 y
docking mostraron que los compuestos 1(a-h) y 2(a-h) pudieran inhibir ambas ciclooxigenasas (COXs), debido al hecho
ambas COXs. Los valores de ΔG fueron obtenidos para todos los compuestos, se encuentran entre –9.87 y –6.65 (Kcal/
en COX-1 y finalmente los valores entre 0.01 y 24.7 en COX-2, donde 1h muestra más afinidad para ambas COX-1 y COX-2.
La Artritis Reumatoide es una enfermedad autoinmune progresiva de etiología multifactorial caracterizada por in_x001
nivel control de los síntomas y evolución de esta enfermedad en los pacientes. Sin embargo, un alto porcentaje de los p
trabajo revisión se hace una comparación entre los tratamientos farmacológicos y de los tratamientos alternativos en b
La somministrazione per via orale è la preferita per il trattamento farmacologico cronico. Circa il 40% dei nuovi principi
biodisponibilità. Infatti l’assorbimento di un principio attivo rilasciato da una forma farmaceutica orale dipende essenzi
quattro classi (Biopharmaceutical Classification System). In particolare per la seconda classe di composti, la dissoluzion
biodisponibilità orale di farmaci lipofilici come per esempio l’incorporazione in veicoli lipidici inerti come olii, la formula
riguardato la preparazione di sistemi attivati a base di ubidecarenone e ciclosporina ricorrendo alla tecnologia NEC  (N
Materiais
(o/a/o) in un mesoporosos
carrier microporoso. têm recebido muita atençãol’attenzione
Successivamente devido as suas características
è stata atrativas comoapplicabilità
focalizzata sull’innovativa estrutura dedelle
mesopomic
aplicação para a sílica mesoporosa como liberação de fármacos tem
direttamente dalle onde elettromagnetiche le quali sono in grado di aumentare l’agitazione termica, e quindi la temper sido explorada devido a sua natureza não-tóxica e
sistema de liberação de fármacos. O naproxeno é um derivado do ácido
microonde. In tale contesto, oggetto della ricerca è stata l’attivazione dell’ibuprofene e piroxicam. Per tutti i farmaci co propiônico e o naproxeno sódico é seu sal. É u
solúvel em pH maisdei
Alla preparazione elevados,
sistemi ha é solúvel
fatto seguitoem etanol e metanol. Seu coeficiente
la caratterizzazione chimico-fisica, de partição
necessaria octanol/água
per appurare a pH 7.4 é de
lo stato cer
solido
d4T, é um fármaco
microscopi (HSM), hidrofílico,
laser-light solúvel
scattering. em água e
Successivamente parcialmente solúvel
le formulazioni em etanol.
approntate Outra importante
sono característica
state caratterizzate é
anche seu d
Background
complexação and purpose:
de SBA-15 Thedoispharmaceutical excipients can be incompatible with drug or other excipients. Thus, forDSe
valutata,
the in alcuni
physico-chemical lacom
casi,properties
possibilità can
fármacos
diresult
realizzare
in
modelos
changesforme (naproxeno
infarmaceutiche
the drug
e estavudina).
solide
release, and
Algumas
uso orale técnicas
adfurthermore quali
in
foram
capsule
its e usadas:
compresse.
bioavailability. In
TG,
ordeIr
naproxeno
dell’obiettivo possuir característica
del presente decioèsolubilidade semelhante a sílica mesoporosa SBA-15, facilitando Le a complexação. O
and environmental factors lavoro
on the ephysical l’aumento
properties della
of biodisponibilità
piroxicam tablets. in vivo dell’Ubidecarenone.
Materials and methods: Piroxicam caratteristiche
tablets wt
anche la forma
six months. Drug di release
dosaggio andin disintegration
compresse. CICLOSPORINA time were analyzed Il prodotto composito
in periods of studypreparato
(baseline, è dunque
3, and 6risultato
months).essere
DSC (d in
polimeri
from scelti hanno
different formulationsportatoafter ad un grado
3 and di amorfizzazione
6 months storage in 25° delCfarmaco
/60% RHtale andda 40°essere
C /75%responsabile dell’incremento
RH showed statistically d
signific
A peptic ulcer
l’applicabilità
formulation is a sore
delle
ingredients. MWinalla thecreazione
lining ofThe
Conclusion: stomach
resultsor
di sistemi ofduodenum.
dispersi The
andduodenum
solvent-free.
dissolution is the
Gli indiscussi
disintegration firstshowed
vantaggi
time partalofricorso
smallkeeping
that intestine. Peptica uM
ad un reattore
piroxicam
Lansoprazole Enteric Coated Pellets drug
stato ottenuto associando alla tecnologia adottata il polimero PVP/VA 64.
tablets. delivery system by using Eudragit L-30D-55, HPMC K5 as retarding agents. Th
were conducted to know the drug excipients compatibility by using FTIR spectroscopy. Based on the results, suitable e
layered method. Finished products were evaluated for friability test, assay, and In-vitro release studies performed for 1
were found within the limit. Invitro dissolution study showed that Formulation F9 having the better resistance in 0.1 N
The
to beaim of this
stable study medium
in acidic was to formulate
and shows and characterize
better drug release bilayer tabletmedium.
in basic of Dicyclomine
Therefore it was an ideal and optimized
with marketed one. The stability study was carried out for formulation F9drug
hydrochloride and Mefenamic acid for colon targeted drug delivery. The at 1, 2, 3 month for invitro dissolution study a
delivery system was based on the gastrointestinal transit time concept. assuming colon
arrival time to be 5 h. Drug polymer compatibility studies were carried out by FT-IR
A 32 Full factorial design was used for optimization of combination of polymer. The
amount of Hydroxypropylmethylcellulose KIOOM or Hydroxypropylmethylcellulose
KISM (X1) and amount of Hydroxypropylmethylcellulose K4M X) were selected
as independent variables. The prepared bilayer tablets were coated with Eudragit S100
(7.5 % w.-"v) by spraying method. Time required for 50 % (T 50-.,) and 80 % (T so-,,) drug
release
The were selected
objective of this study as dependent
was to evaluate variables. Tablets were evaluated
the encapsulation performance for hardness,
of Croscarmellose sodium, a superdisintegr
fiiability, weight
poor-solubility drug variation.
formulationdrug content.
and the in-vitroin vitro dissolution
drug release and stabilityofstudy.
performance the Piroxicam capsules. Preparation, chara
Comparative
evaluation dissolution
of the effects of profiles of all the
the different batches indicate
concentrations drug release
of carmellose from tablet
sodium and the amount of dried starch on in-vit
was directly
Piroxicam affectedPiroxicam
capsules. by amount was ofchosen
polymer. forFromits very thelow release profile
solubility in itbiological
was fotmd thatwhich result in poor systemic bi
fluids,
the sustained
after release of Dicyclomine
oral administration. Piroxicam can hydrochloride
be categorized andas Mefenamic
Class II drugs acidaccording
was to the Biopharmaceutics Classificatio
The
This aim
drugofis
obseived the
for the
poorlypresent
bilayer
water investigation
tablet
soluble, butwas
containing once toadissolved,
prepare
higher amount and of HPMC.
it is easily absorbed The through
kinetics the gastro-intestinal membrane. The
evaluate
release of
formula the
includesMisoprostol
optimized lactose batch mucoadhesive
(CPB)
as the mainwasfiller microspheres
bestalongexplainedwith corn by forHiguchi
starch,and sodiumKorsmeyer-
lauryl sulphate and magnesium stearate. A 32
gastroretentive
Peppas kinetic model.
full factorial drug delivery.
The coated Sodium bilayeralginate
tablets and weresodiummost likely to provide targeted
carboxy
delivery
design methyl
wasof Dicyclominecellulose
applied to investigate were used
hydrochloride as mucoadhesive
and Mefenamic
the combine effect ofacid to the colon
2 formulation From the
variable: Dried starch and Croscarmellose sodium
polymers.
formulation Microsphere
results ofis stability
approach study, formulations
it was
helped in observed werethat
understanding prepared
the usingofformulation
theselected
effect formulation CPB was stable
processing variables. Percent drug dissolved i
Arthritis
Ionotropic a major
gelation cause of
technique. disability and morbidity, particularly in older individuals. The
for the one
increase
symptoms in andmonth
the level
signs atof40°C.
of 75%All RH
superdisintegrant.
arthritis and
the microspheres
asrelated
specified
These by the
results
conditions
wereICH
show guidelines.
include that
pain,Croscarmellose
stiffness, sodium can be successfully used to p
swelling,
characterized
capsulesweakness, for particle size,
AB bioequivalence ratedscanning electron
muscle
microscopy, FT-IR study, and limitation
percentage oftomovement
FELDENE, innovator products.
yield, drugof the joints.
The objective of the present work
entrapment, stability studies and for in vitro release was to provide a dosage form for localized action of
drugs used
kinetics. Based in treatment
on the results, of arthritis to the
the formulationdrug affected tissues for prolonged period and to
M12suggested
was
Naproxen,
avoid side a non-steroidal
effects in non-targetanti-inflammatory
organs. To achieve this, for the liposomes
drug loaded long term and treatment of disease conditions such as
selected
Naproxen as(500mg)
optimized is formulation.
prepared in In vitro drugwith
combination release Pantoprazole, a proton pump inhibitor as a multi-layer coated tabl
transferosomes
study ofapplied
optimized were prepared for
formulation Nonsteroidal
M12product.
showedThe 98.23% antiafter
inflammatory drugs and further
layer is
incorporated to get
in transdermal combination gel formulation. The prepared
formulations tablets were evaluated
were prepared by for physicochemical properties such
12 h in a controlled
multi-layered tablets manner, which
in 0.1Nscreened
HCl and is 7.4
essential
pH phosphatefor anti ulcer
buffer. The analytical results obtained at several stages of prepa
Experimental
therapy.that Thethe design
marketed using factors and their levels and by optimized process
shown
parameters. release product
of drugs shows follow the zerodrug order release
kinetics. of
Ranitidine
95.23 within Hydrochloride
1 h. The results hasofamucoadhesion
very bitter taste. studyThe bitter taste of the drug makes administration of the dosage
The
form
showedtransdermal
difficult,
betterespecially drug permeation
retention toofpaediatric
prepared waspatients.
found toOral
microspheres be highest
(8) h in for transferosomal
medicated jellies are novel gel, drugwhereas
delivery systems overcoming
drug
these was found
problems. to be
They slightly
are sucroseretained
chic duodenal and jejunum regions of intestine. The resultsbased in skin during
formulation permeation
thus providing from liposomal
higher gel
compliance. These formulations are also
formulation.
advantageous The for reason
geriatric may and be
showed significant higher retention of mucoadhesive fusion
dysphagic of Phospholipids
patents. Natural during diffusion
polymers used through
in jelly skin.
formulation are biodegradable,
Both the Transferosomal
biocompatible,
microspheres in nontoxic,
upper GI gel
low
tract.formulation
cost and Liposomal
and environment
Pharmacokinetic study gel formulation
friendly, locally available,showed sustained
better patient tolerated and edible.
This
The study
release
aim of
was is part
drugto for ofmore
develop a research 6project
thanevaluate
and hrs. aimed
oral jellytoformulations
find and optimize methods
of Ranitidine by which drug-excipient
Hydrochloride. Preformulation compatibility
studies, can b
revealed
pharmaceuticalthat the bioavailability
excipients of was found
common use to be
including increased
diluents, binders, disintegrants, lubricants
Based on thewhen
organoleptic,
significantly pharmacokinetic
physical studies,
characteristics,
compared with bothcontent,
drug
marketed the
tablets.liposomal
pH,
The gel and transferosomal
syneresis, taste masking and gel in vitro dissolution testingagents.
were and solubilising
completed
found
were to have
conducted.by Fourier
better transform
bioavailability
The Fourieroptimized infrared
as spectroscopy
compared
transformformulation
infrared andM12 to plain (FT-IR)
gel of and X-ray
Aceclofenac. powder
differential scanning calorimeter studies diffraction were used that
showed for compatibility
there
drug
by release
mixing the ofanalyte
Misoprostoland excipients in a proportion of 1:1 (w:w). On the basis of thermal results (especially DSC), confi
Both
was the transferosomal
no interaction
followed zero order, between and
Higuchi liposomal
drug
and gel showed better anti-inflammatory action
and excipients. The concentration of gelling agents influenced the spreadability.
Korsmeyer-Peppas and
interaction
analgesic
The formulation with
action than colloidal silicon
marketed
F4diffusion
showing good dioxide
gelpourabilty and
of Aceclofenac stearic
and gelling acid
(Marketed(Ac. St.).
property gel).so it was selected for further optimization by
kinetics indicating controlled with non-Fickian
varying the degrees brix (⁰Brix). The
(anomalous) transport thus it projected that delivered its pH of all the formulations was found between pH 5 to 6. The optimized
formulations (F4.3) masked the bitter
active ingredient by coupled diffusion and erosion. Overall, taste of Ranitidine Hydrochloride and demonstrated acceptable physical
properties with 50% prolonged
the result indicated drug release in 15 min.
delivery withThe formulation was tested for microbial growth and was found to be
improved
stable.
bioavailability of Misoprostol from mucoadhesive
microspheres due to higher retention in the upper GI tract.
The present study was aimed to prepare the Gemifloxacin mesylate floating
microspheres by Ionotropic gelation technique with different drug to carrier ratio.
Gemifloxacin mesylate All the microspheres were characterized for particle size, scanning
electron microscopy, FT-IR study, DSC, percentage yield, drug entrapment, % buoyancy,
stability studies and found to be within the limits. Among all the formulations F9 were
The present
selected study involves
as optimized the investigation
formulation based on the of certain
physic fundamental
chemical andphysical and chemical
release studies. In theproperties
in of Etodolac loade
(NSAIDS).Before the development of any dosage form it is essential
vitro release study of formulation F9 showed 97.58% after 12 h in a controlled manner, which to study the compatibility of drug and excipients,
tablets were done by solvent evaporation method by using the polymers
is essential for anti ulcer therapy. The innovator Gemiflox conventional tablet shows the drug like Eudragit S 100, Ethyl cellulose and polyvin
results from experiments, it is found the Etodolac is found to compatible
release of 96.23% within 1 h. The drug release of F9 formulation followed zero order and with the excipients like Eudragit S 100, Ethyl C
Higuchi
Os métodoskinetics indication diffusion
termo-analíticos controlled úteis
são ferramentas drug na release
avaliação da compatibilidade entre fármacos e adjuvantes, com
usualmente empregados em formas farmacêuticas sólidas. A compatibilidade foi examinada por meio da preparação d
adjuvantes com função de material de enchimento e carga e deslizante. A isoniazida apresentou um comportamento t
estearato de magnésio, glicolato de amido sódico, hipromelose, lactose, manitol, polidona e talco. Para as misturas físi
povidona. A isoniazida mostrou a formação de uma mistura eutética com o manitol e de interação química com a lacto
Dierential
por métodos não-térmicos como difratometria de raios X, espectroscopia de infravermelho e ressonância nuclear mag
scanning calorimetry (DSC) was used to investigate and detect incompatibilities between drugs such as: ibuprofen
(IBU) or ketoprofen (KETO) with cellulose ether derivatives, which are frequently applied on controlled release dosage
Binary mixtures concerning methylcellulose (MC25) or hydroxypropylcellulose (HPC) with hydroxypropylmethylcellulo
(HPMC) K15M or K100M in dierent
The
ratiosaim of this
were study was
prepared and to developby
evaluated anthe
enteric-coated
appearance,multiunit dosage form containing
shift, or disappearance of peaks aceclofenac, a nonsteroidal a
drug. The pellets were prepared by using extrusion/spheronization
and/or variations in the corresponding ΔH values. According to the DSC results, binary method, and the core pelletsbetween
mixtures were coated
those polyme
with a pH-sensitive poly(meth) acrylate copolymer (Eudragit L100-55) to achieve site-specic
found to be compatible, but their mixture with IBU or KETO, promotes a solid–solid interaction mainly with 1:1:1 (w/w)
drug release. TheHowever,
(drug-excipient). formulated when the drug:excipient interactions were detected, they were not found to aect
pellets
the drug were characterized for percentage yield, size distribution, surface morphology studies, drug content, and ow
Introduction:
properties. Over
In vitro the past fewtest
decades, nanoparticles (NPs)ofhavedruggained immeasurable interest in the eld
bioavailability.
of drug delivery.DSC dissolution
was successfully was used
employed fortocomparison
evaluate the release
compatibility proles
of the drugs with the selected polymers
of various coated pellets. The practical
Various
yield was NPfound
formulations
to be 90–95%.have been disseminated
The particle size of in drug development
enteric-coated pelletsinwas
an attempt
found toto beincrease ecacy,
in the range of 0.59–0.71 mm.
safety and
pellets were spherical in shape and surfaces of pellets were found to be rough and showing micropores. Enteric-coated
tolerability
showed good of incorporated
ow drugs. In this context, NP formulations that increase solubility, control release, and/or aect
the in
properties and in vitro dissolution prole.
vivo disposition
Dissolution testsofwere
drugs, wereout
carried developed
in a USPto improve
type the pharmacokinetic and pharmacodynamic properties of encap
II dissolution
drugs.
apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the aceclofenac from formula
Areas
pelletscovered: In this article,
was established importantinproperties
to be minimum the pH 1.2related
(<5%) for to aNP function
period of 2such
h, andasat
particle
pH 6.8,size, surface
it shows thecharge
maximumand shap
rele
disseminated. Also, the current understanding of how NP characteristics aect
(85 ± 5% release within 1 h) which indicates gastric resistance of the formulated pellets. The 20% wt/wt enteric-coated p
particle uptake and
were compared targeted
to that deliveryproduct
of marketed is (tablets), it was observed that pellets showed better release prole.
elucidated.
The study Selected NP systems currently used in delivery of drugs in biological systems and their production methods
discussed
concludedas well.
that theEmphasis
formulated is placed on currentdosage
multiparticulate NP formulations
forms canthat are shown
be used to reduce
as an ideal drug-induced
drug delivery system adverse
for therenal
complications.
aceclofenac.
Expert opinion: Formulation designs utilizing NP-encapsulated drugs oer
alternative pharmacotherapy options with
improved safety proles
for current and emerging drugs. NPs have been shown to increase the therapeutic index of several
entrapped
The eect ofdrugs mostly
cellulose ether bypolymer
decreasing drug localization
mixtures, containingand both side eects
hydroxypropylcellulose (HPC) and hydroxypropylmethyl
on organs. Recent studies on NP-encapsulated
spectroscopy, scanning electron microscopy (SEM), and X-ray powder diraction (XRPD) experiments were performed.
chemotherapeutic
containing mixturesand antibiotic with
of polymers medications
both lowshow enhanced
and high therapeutic
viscosity grades wereoutcomes
preparedby altering drug
by a direct degradation,
compression incr
meth
systemic
within thecirculation
range 113.8 and/or enhancing
to 154.9 N. HPLCcell specicshowed a drug content recovery between 99.3 and 102.1%, indicating th
analysis
targeting. They may also
to tablet dissolution. reduce the distribution
Independent-model of encapsulated
dissolution parameters drugssuch as into
t and t dissolution times, dissolution eciency (
the kidneys and attenuate drug-associated adverse renal complications.
interpret the dissolution proles: a predominantly Fickian diusion release mechanism The usefulness wasof NP formulation
obtained in reducing t
– with Korsmeyer–P
nephrotoxicity of nonsteroidal anti-inammatory
drugs is an underexplored territory that deserves more attention.
Meloxicam (MEL) shows a slow onset of action in severe pain patients on account of delayed gastric motility. This stud
MEL/HPMC) and polyacrylates and polymethacrylates (ASD-MEL/EUD) were prepared and physicochemically character
amorphous, and ASD formulations of MEL exhibited high dissolution behavior in acidic solution. After oral administrati
approximately 9- and 12-fold increases of AUC0-4 in normal and PPT-pretreated rats, respectively, in comparison with c
revealed potent interactions between MEL and EUD, possibly leading to marked attenuation of MEL absorption. This A
Using pharmaceutical salts in solid dosage forms can raise stability concerns, especially salt dissociation which can adv
present article uses the fundamental theory of acid base, ionic equilibrium, relationship of pH and solubility as a startin
formation and disproportionation are reviewed in detail. Factors influencing salt stability in solid dosage forms are scru
manufacturing will be suggested herein. This article will provide formulation scientists and manufacturing engineers an
Informa UK Limited, trading as Taylor & Francis Group.
The purpose of the study was to investigate and characterize the oral lyophilisates containing the pregabalin-acetamin
implications, impact of excipients on drug release and on the physicochemical and mechanical properties of the pharm
homogeneity of the prepared pharmaceutical formulations. The formulations were evaluated for in vivo absorption in
determined physical and biochemical parameters of the formulations it was established that they are stable, homogen
bonds between the excipients and the ‘codrug’ complex, which do not affect the release of the bioactive compounds
Purpose: In the present study the incompatibility of FLM (fluvoxamine) with lactose in solid state mixtures was investig
spectrometry. Methods: Non-Isothermally stressed physical mixtures were used to calculate the solid- state kinetic par
Results: Overall, the incompatibility of FLM with lactose as a reducing carbohydrate was successfully evaluated and the
FTIR. It was shown that DSC- based kinetic analysis provides fast and versatile kinetic comparison of Arrhenius activatio
The objective of the present studies was systematic development of floating-bioadhesive gastroretentive tablets of ce
and quality attributes of tablet were earmarked, and preliminary studies were conducted for screening the suitability o
material attributes, i.e., concentration of release controlling polymers, PEO 303 and HPMC K100 LV CR, and evaluating
characteristic with drug release control (i.e., T60% > 6 h) and bioadhesion strength. Drug-excipient compatibility stu
vivo pharmacokinetic studies in rabbits revealed significant extension in the rate of drug absorption (i.e., Tmax, Ka, and
degree of prognostic ability of in vitro dissolution conditions in predicting the in vivo performance. In a nutshell, the st
Objective: The aim of the present investigation was the development and in vivo characterization of domperidone (DO
variables and tensile strength (Y1), percent drug release at 6 h (Q6, Y2) and percent drug permeated at 6 h (Y3, P6) as
release, bioadhesion, swelling and erosion, ex vivo permeation. Furthermore, statistically optimized formulation was s
63.36 ± 2.12% of drug permeated in 6 h. HME films demonstrated no drug excipient interaction and excellent content u
(8.5%). Bioavailability from the statistically optimized buccal films was 3.2 times higher than the oral dosage form (p50.
were detected in 6 months. Conclusion: The results indicate that hot-melt extrusion is a viable technique for the prepa
The objective of this study was to investigate blends of cashew and xanthan gum as a potential carrier for colonic deliv
varying blends of cashew and xanthan gum were prepared by direct compression. Drug-excipient compatibility and the
6.8; 7 h), without enzymes, were studied. Cashew gum produced lower moisture content, swelling capacity, total ash,
ibuprofen and the excipients and the tablets exhibited higher swelling capacity in phosphate buffers (pH 6.8 and 7.4) t
formulation F3 (cashew and xanthan 1:1) was most promising for colonic drug delivery with minimal (~13 %) ibuprofen r
release involved both diffusion and erosion of the hydrated gum matrices. The studies have demonstrated the potentia
Stress stability testing represents an important part of the drug development process. It is used as an important tool fo
stability of olanzapine confirms that levels of impurities and degradants are limiting parameters and are therefore used
determined by using LC-MS, IR and NMR. Compatibility and stress stability results demonstrated that tablet formulatio
the degradation followed zero-order kinetics. In addition, studies of olanzapine with excipients and in formulated table
powder diffraction (XRPD) analysis and exhibited no correlation between the phase change (appearance of a new poly
Ceftriaxone (CFTX) sodium is a semisynthetic antibiotic that can effectively treat several types of bacterial infections. Id
the best excipients for stable dosage forms constitute, a real achievement in the pre-formulation stage. Recently by th
was to study the compatibility of Ceftriaxone drug substance with the excipients employed in colon target release cap
found to be compatible with Chitosan and Sodium tri polyphosphate. FTIR was used as supportive techniques for the a
Memantine is a clinically useful drug in many neurological disorders, including Alzheimer's disease. The mechanism of m
Preformulation is the first step in the rational formulation of an active pharmaceutical ingredient (API). For any formula
selection of suitable study method to evaluate the interaction between the drug and the excipients is a prime most ach
memantine drug substance with the excipients employed in the formulation of nanoparticle for nasal drug delivery sys
to be compatible with excipients chitosan and Sodium Tripolyphosphate.
Ocular films of ofloxacin and ketorolac tromethamine were prepared with objectives of reducing the frequency of adm
solvent casting method. The ocular films were evaluated for drug-excipient interaction, physico-chemical characteristic
All the formulations were subjected to evaluation of thickness, weight variation, folding endurance, drug content unifo
to be better than the other formulations and it was selected as an optimized formulation.
Estimation of drug-excipient interactions is a crucial step in preformulation studies of drug development to achieve con
FT-IR, solid state NMR and PXRD into pre-formulation studies have contributed significantly to early prediction, monito
required to arrive at an appropriate formulation. Concomitant use of several thermal and spectroscopic techniques allo
on the techniques for compatibility screening of active pharmaceutical ingredient with their potential merits and deme
Purpose: Curcumin is a hydrophobic polyphenol isolated from dried rhizome of turmeric. Clinical usefulness of curcumi
fabricate curcumin-piperine, curcumin-quercetin and curcumin-silibinin loaded polymeric nanoformulation. However, u
with excipients used in nanoformulations. Methods: Isothermal stress testing method was used to assess the compatib
quercetin and silibinin have not shown any significant physical and chemical instability. Conclusion: The study conclude
Polyethylene glycols (PEGs) are attractive as excipients in the manufacture of drug products because they are water s
In this study, kinetics of two active pharmaceutical ingredients, cetirizine and indomethacin possessing carboxylic acid
was used to identify reaction products. The esterification reactions were observed to be reversible. A second-order rev
shelf-life for cetirizine in a PEG 400 formulation at 25C expressed as t95% was predicted to be only 30 h. Further, rate co
drug-excipient interaction, as it can reduce the shelf-life of a low-average molecular weight PEG formulation considera
The aim of the present study is to develop, optimize, characterize and evaluate the gemifloxacin microcapsules prepar
were successfully prepared by o/o emulsification-solvent evaporation technique using different concentrations of poly
drug release data, the formulation having higher drug release that is F6 was selected as the optimized formulation. It w
dissolution rate also increased with sustained release of drug. The optimised formulation F6 was characterized for part
and physical change of drug by differential scanning calorimeter(DSC). The percentage yield and entrapment efficiency
presence of combination of polymers. The drug release of optimized formulation is higher compared with the drug rele
order release kinetics. It was found that gemifloxacin microcapsules sustained the release of gemifloxacin.
The objective of this study was to develop paclitaxel (PTX) loaded poly(ε-caprolactone) (PCL) based tiny implants. β-Cy
color, shape, thickness, surface area, weight, drug content. Developed implants were characterized for their surface m
the tiny implants were white in color and cylindrical in shape with smooth surfaces. PTX was entrapped within implant
and method of preparation did not affect chemical stability of PTX. © 2012 King Saud University.
Drug-excipient interactions in solid dosage forms can affect drug product stability in physical aspects such as organolep
interactions and from drug interactions with excipient impurities. A review of chemical instability in solid dosage forms
aspects of solid-state reactions with excipients and/or excipient impurities add to the complexity in understanding and
Recent developments in the understanding of degradation pathways further impact methodologies used in the pharm
accelerated stability testing, and application of mathematical modeling for prediction of drug product stability.
The objective of this work was to formulate and evaluate the floating tablets of atenolol. Tablets were prepared by dir
dicalcium phosphate as diluent, magnesium stearate, talc as lubricant and glidant. Drug excipients compatibility studie
carboxymethylcellulose as well as their combinations on the drug release profiles was studied. The release mechanism
non-Fickian or anomalous transport. Other parameters such as thickness, hardness, friability and drug content were fo
parameters, formulations F5 and F11 were selected as best formulation and subjected for stability studies as per ICH gu
swells which resulted in the formation of pores through which drug diffuses into the release media
The stability of hydroxypropyl methylcellulose acetate succinate (HPMC-AS) and its potential incompatibility with activ
of succinic acid and acetic acid, which can form ester bond(s) with the hydroxyl group(s) in API. In this case, the hot-m
epimer were found in the product, suggesting potential drug - excipient incompatibility during formulation developme
This paper presents the results obtained after studying the thermal stability and
decomposition kinetics of perindopril erbumine as a pure active pharmaceutical
ingredient as well as a solid pharmaceutical formulation containing the same
active pharmaceutical ingredient (API). Since no data were found in the
literature regarding the spectroscopic description, thermal behavior, or
decomposition kinetics of perindopril, our goal was the evaluation of the
compatibility of this antihypertensive agent with the excipients in the tablet
under ambient conditions and to study the effect of thermal treatment on the
stability of perindopril erbumine. ATR-FTIR (Attenuated Total Reflectance Fourier
Transform Infrared) spectroscopy, thermal analysis (thermogravimetric mass curve
(TG-thermogravimetry), derivative thermogravimetric mass curve (DTG), and heat
flow (HF)) and model-free kinetics were chosen as investigational tools. Since
thermal behavior is a simplistic approach in evaluating the thermal stability of
pharmaceuticals, in-depth kinetic studies were carried out by classical kinetic
methods (Kissinger and ASTM E698) and later with the isoconversional methods of
Friedman, Kissinger-Akahira-Sunose and Flynn-Wall-Ozawa. It was shown that the
main thermal degradation step of perindopril erbumine is characterized by
activation energy between 59 and 69 kJ/mol (depending on the method used), while
Currently
for themarketed
tablet, theminoxidil
values wereformulations present
around 170 inconveniences
kJ/mol. that range
The used excipients from
(anhydrous
acolloidal
grease silica,
hard aspect they leavecellulose,
microcrystalline on the hair to more
lactose, and serious adverse
magnesium reactions as
stearate)
scalp
shoulddryness
be usedand irritation. In this paper
in newly-developed wesolid
generic propose a novel approach
pharmaceutical for
formulations,
minoxidil
since theysulphate
contribute(MXS)
to andelivery based
increased on a solid
thermal effervescent
stability formulation.
of perindopril erbumine.The
aim was to investigate whether the particle mechanical movement triggered by
effervescence would lead to higher follicle accumulation. Preformulation studies
using thermal, spectroscopic and morphological analysis demonstrated the
compatibility between effervescent salts and the drug. The effervescent
formulation demonstrated a 2.7-fold increase on MXS accumulation into hair
follicles casts compared to the MXS solution (22.0+/-9.7mug/cm(2) versus
8.3+/-4.0mug/cm(2)) and a significant drug increase (around 4-fold) in remaining
skin (97.1+/-29.2mug/cm(2)) compared to the drug solution (23.5+/-6.1mug/cm(2)).
The effervescent formulations demonstrated a prominent increase of drug
permeation highly dependent on the effervescent mixture concentration in the
formulation, confirming the hypothesis of effervescent reaction favoring drug
penetration. Clinically, therapy effectiveness could be improved, increasing the
administration interval, hence, patient compliance. More studies to investigate
the follicular targeting potential and safety of new formulations are needed.
The purpose of this study was to investigate the in-depth pharmaceutical
properties and in vivo behavior of a novel lyophilized rapidly dissolving solid
ocular matrix (RD-SOM) as a 'solid eye drop' formulation comprising timolol
maleate as the model drug. Thermal and molecular transition analysis displayed
similar findings with no incompatibility between formulation components.
Porositometric studies confirmed the presence of interconnecting pores across the
matrix surface. The HETCAM test indicated an irritation score of 0 with the
inference of good tolerability for the RD-SOM in the New Zealand White albino
rabbit eye model. Ex vivo permeation across excised rabbit cornea showed an
improved steady state drug flux (0.00052 mg cm(-2)min(-1)) and permeability
co-efficient (1.7 x 10(-4)cmmin(-1)) for the RD-SOM compared to pure drug and a
marketed eye drop preparation. UPLC analysis quantitatively separated timolol
maleate and the internal standard (diclofenac sodium) and gamma irradiation was
used as a terminal sterilization procedure. In vivo results revealed a peak
concentration of timolol was reached at 104.9 min. In the case of a typical eye
drop formulation a lower Cmax was obtained (1.97 ug/mL). Level A point-to-point
IVIVC plots via the Wagner-Nelson method revealed a satisfactory R(2) value of
0.84. In addition, the biodegradability and ocular compatibility of the RD-SOM
was confirmed by histopathological toxicity studies.
Estimation of drug-excipient interactions is a crucial step in preformulation

studies of drug development to achieve consistent stability, bioavailability and
manufacturability of solid dosage forms. The advent of thermoanalytical and
spectroscopic
Tamoxifen citratemethods
(Tmx) was like DSC, isothermal
formulated microcalorimetry,
in nanostructured HSM, system
lipid carrier SEM, FT-IR,
solid state
(NLC) usingNMR
longand PXRD
chain solidinto pre-formulation
lipids (LCSL) and oilsstudies
(LCO) have contributed
with the aim to target
significantly
lymphatic to early
system to prediction,
improve its monitoring andincharacterization
bioavailability of the active
plasma and lymphnode (initial
pharmaceutical
sites ingredient
for metastasis) incompatibility
and reduce with pharmaceutical
its drug associated excipients
toxicity. Tamoxifen to avoid
loaded
expensive
NLC material
(Tmx-NLC) waswastage
formulated andusing
considerably reduce the
solvent diffusion time required
technique. to arrive at
Preformulation
an appropriate
studies comprised formulation.
evaluationConcomitant use of compatibility.
of drug-excipients several thermal and spectroscopic
Solubility of Tmx
techniques
was screened allows
in LCSLan in-depth
and LCO,understanding
surfactants and ofco-surfactants
physical or chemical
to identify NLC
drug-excipientSurfactant
components. interactions and aids in selection
co-surfactant of the
combinations most
were appropriate
studied for their ability
excipients
to stabilizeinthedosage
system. form design.was
Tmx-NLC Thephysicochemically
present review focuses on the techniques
characterized by TEM, DSC,
for compatibility
XRD, screening
and FTIR studies. of active pharmaceutical
Drug-excipients ingredientstudy
chemical compatibility with facilitated
their
potential merits
anticipation and demerits.
of excipients inducedFurther, the review
oxidative highlights
degradation the applicability
of Tmx. Suitable storage
of these techniques
condition using specific
below 30 degrees C coulddrug-excipient
stabilize Tmx.compatibility
Tmx-NLC with case studies.
>90% entrapment
efficiency and 215.60 +/- 7.98 nm particle size were prepared and freeze dried.
Freeze dried Tmx-NLC could withstand various gastrointestinal tract (GI) media
(pH 1.2, pH 3.5, pH 4.5, pH 6.8, pH 7.4). Dissolution profile of Tmx-NLC in
various media showed sustained release pattern irrespective of pH of medium. No
significant change in characteristics of Tmx-NLC was observed after 3 months of
accelerated stability studies.
This work aimed the studies of physicochemical characterization, thermal

stability, and compatibility of benznidazole (BNZ) drug by spectroscopy (NMR,
IR), thermoanalytical (differential thermal analysis, differential scanning
calorimetry, and thermogravimetry), and chromatographic (HPLC) techniques, beyond
the analytical tools of Van't Hoff equation and Ozawa model. The compatibility
study was conducted by binary mixtures (1:1, w/w) of the drug with
microcrystalline cellulose 102 and 250, anhydrous lactose, and sodium starch
glycolate. The physicochemical characterization confirmed data reported in
scientific literature, guaranteeing authenticity of the analyzed raw material.
The drug melts at 191.68 degrees C (H, 119.71 J g(-1)), characteristic of a
non-polymorphic raw material, and a main stage decomposition at 233.76-319.35
degrees C (m, 43.32%) occurred, ending the study with almost all mass
Using L-cysteine chewing gum to eliminate carcinogenic acetaldehyde in the mouth
during smoking has recently been introduced. Besides its efficacy, optimal
properties of the gum include stability of the formulation. However, only a
limited number of studies exist on the compatibility of chewing gum excipients
and stability of gum formulations. In this study we used the solid-state
In the present
stability study,Fourier
method, the aimtransform
was to optimize
infraredanspectroscopy
orodispersible andformulation
isothermalof
indomethacin using a combined approach of subliming
microcalorimetry to investigate the interactions between L-cysteine agent and superdisintegrant.
(as a free
The tablets were made by non-aqueous wet granulation
base or as a salt) and excipients commonly used in gum. These excipientstechnique with include
superdisintegrant incorporated
xylitol, sorbitol, magnesium both intragranularly
stearate, Pharmagum S, and Everyextragranularly.
T Toco and Smily A 2(3)
2
factorial design was used to investigate the effects amount of
Toco. The influence of temperature and relative humidity during a three-month subliming agents
namely
storage camphor
period onandgum ammonium
formulation bicarbonate and taste
was also studied. masking
Cysteine andwas
alone soothening
stable at
hydrophilic
25 degrees C/60% RH and 45 degrees C/75% RH whether stored in open ortime
agent mannitol as independent variables and disintegration and
closed
crushing strength as dependent responses. The volatilization time
glass ambers. As a component of binary mixtures, cysteine base remained stable at of eight hours
at 50 degrees
lower C wasand
temperature optimized
humiditybybut
conducting solid-state
the salt form kinetic studies
was incompatible ofall the
with
optimized formulations. Optimized orodispersible tablets were
studied excipients. The results obtained with the different methods corresponded evaluated for
wetting time, water absorption ratio, porosity and in vitro and in
with each other. At high temperature and humidity, excipient incompatibility with vivo
disintegration tests. Results
both forms of cysteine show that
was obvious. higher
Such levels of
sensitivity tocamphor
heat and and mannitol
humidity and
during
astorage
lower level of ammonium bicarbonate is desirable for orodispersion.
was also seen in studies on gum formulations. It was also found that Scanning
electron
cysteine is microscopy (SEM)
sensitive to high revealed
pressure the
andporous
increase surface morphology
in temperature and kinetic
induced by
digital images substantiated the orodispersible property. Differential
compression. The results suggest that the final product should be well protected Scanning
Calorimetry
from temperature(DSC) studies exhibited
and humidity and,physiochemical
for example, coolingcompatibility
processbetween
before
indomethacin and various excipients
compression should be considered. used in the tablet formulation. Stability
studies carried out as per ICH Q(1) A guidelines suggested the stable
formulations for the tested time period of 6 months. The systematic approach of
using subliming and disintegrating agents helped in achieving a stable, optimized
orodispersible formulation, which could be industrially viable.
Boswellic acids have long been considered the main bioactive components of
frankincense, and many studies in vitro and in animals as well as several
Naltrexone hydrochloride
clinical studies (NTX) is their
have confirmed an innovative drug used inInophthalmology
various bioactivities. particular, a for
treatment
large number of ocular surface diseases
of mechanistic such confirmed
studies have as impairedtheircorneal wound healingand
anti-inflammatory and
severe
antitumordry activities.
eye. Poor However,
chemical stability
not every has been a major
boswellic limitation
acid exhibits for
a satisfactory
development
pharmacological of NTX in solutionwhich
performance, form. depends
The aim of onthis
thestudy wasstructure
chemical to develop and
and
characterise NTX inofsitu
functional groups theocular films
acid. To for enhanced
enhance chemical stability
the pharmacological and
values of boswellic
improved ocular tolerability.
acids, derivatization has beenThe films were
specifically prepared
applied withfrom different
the aim amorphous
of discovering
polymers
more active and characterised
derivatives for In
of BAs. physicochemical compatibility,
addition, the preliminary moisture-sorption,
pharmacokinetic
surface
studies ofpH,these
mechanical
compoundsproperties, sterilisability,
using various standardsurface
methodsmorphology,
show their poor
mucoadhesion,
bioavailability ininhumans
vitro release, conjunctival
and rodents, whichirritation
has led toand accelerated
questions stability
of their
at 40 degrees C/75%
pharmacological relativeand
relevance humidity for 3 months.
potentially Glycerin
limits their use in (GLY)-plasticised
clinical practice
films exhibited significantly
and pharmaceutical better mechanical
development. To improve properties,
these effects,compared with
some approaches have
polyethylene glycol (PEG) 400 and triethylcitrate (TEC)-plasticised
shown some improvements in effectiveness, and the new formula compatibility formulations.
Superior
approachmucoadhesion
is considered awas veryrecorded
reasonable for method
F7 and F9 forplasticised
improvingwith the GLY and PEG
bioavailability
400, respectively.
of boswellic acids.The stability of NTX was significantly enhanced more than
18-times, compared with the solution form. Combination of carboxymethylcellulose
sodium (CMC) and sodium alginate (ALG) in a film formulation demonstrated minimal
% moisture sorption, good mechanical properties, in vitro release, excellent
chemical stability and minimal conjunctival irritation lending them as promising
ocular formulations.
The present investigation deals with the optimization, formulation, and

characterization of oral in situ gel of spiramycin. Sodium alginate and
hydroxypropyl methylcellulose were used as cross-linking and viscosifying agents,
respectively. Sodium bicarbonate was used as a floating agent. In preformulation
studies, the melting point, pH, and partition coefficient were found to be 133
degrees C, 9.5, and 0.193, respectively. The drug had retention time at around
2.65 minutes in high performance liquid chromatography (HPLC). During
compatibility studies of drug with all polymers, we observed that there were no
changes in the FTIR spectra of a mixture of drug and polymers. All the
formulations showed good pourability. Floating time and total floating time were
~30 sec and >12 hours, respectively. During in vitro drug release studies, the
drug was released from the formulation around 80-100% for 12-16 hrs. In TEM
analysis, we found that the drug molecules were well entrapped in the polymer and
the drug was released slowly for up to 12 hrs. In these studies, we found that
the concentration of sodium alginate and HPMC had significant influence on
floating lag time, gelling capacity, and cumulative percentage drug release.
During antimicrobial studies, we found that the formulation containing spiramycin
plasticizing properties, respectively. The physicochemical compatibility of the
drug and the polymers was performed by differential scanning calorimetry and
Fourier transform infrared (FTIR) spectroscopic technique. Effects of EC and PDMS
ratios on moisture uptake, moisture content, tensile strength (TS), Young's
modulus, adhesive strength, water vapor transmission rate (WVTR) and in vitro
permeation of centchroman through Sprague-Dawley rats abdominal skin using
Franz's diffusion cell were evaluated. A 3(2) full factorial design was employed
to observe the effect of independent variables; concentration of ethyl cellulose
and PDMS on drug permeated after 32 h, which was selected as dependent variable.
Compatibility studies suggested that there were no significant interaction
between the drug and polymers used. It was found that incorporation of only EC
resulted in too hard patches and addition of PDMS produced patches with lower TS,
increased percentage elongation, WVTR and Young's modulus. Statistical analyses
suggested that independent variables have a significant effect on the dependent
variable. All formulation follows zero-order release kinetics with r(2) > 0.990.
In conclusion, drug in adhesive transdermal patches can be successfully
fabricated for non-steroidal contraceptive centchroman to obtain a zero-order
release systems.
The aim of the present study was to investigate transfersomes as a transdermal

delivery system for the poorly soluble drug, sertraline, in order to overcome the
troubles associated with its oral delivery. Different transfersomal formulations
were prepared with non-ionic surfactant (span 80), soya lecithin, and carbopol
940 by the rotary evaporation sonication method. The prepared formulations were
characterized for light microscopy, particle size analysis, drug entrapment,
turbidity, drug content, rheological studies, in vitro release, ex vivo
permeation, and stability studies. The optimized formulation was evaluated for in
vivo studies using the modified forced swim model test. FTIR studies showed
compatibility of the drug with excipients. The result revealed that sertraline in
all of the formulations was successfully entrapped with uniform drug content.
Transfersomal gel containing 1.6% of the drug and 20% of span 80 was concluded to
be the optimized formulation (EL-SP4), as it showed maximum drug entrapment
(90.4+/-0.15%) and cumulative percent drug release(73.8%). The ex vivo permeation
profile of EL-SP4 was compared with the transfersomal suspension, control gel,
and drug solution. The transfersomal gel showed a significantly higher (p<0.05)
cumulative amount of drug permeation and flux along with lower lag time than the
drug solution and drug gel. It also owed to better applicability due to the
higher viscosity imparted by the gel rather than the transfersomal suspension,
and no skin irritation was observed. The modified forced swim test in mice
revealed that the transfersomal gel had better antidepressant activity as
compared to the control gel. Thus, the study substantiated that the transfersomal
gel can be used as a feasible alternative to the conventional formulations of
sertraline with advanced permeation characteristics for transdermal application.
A multiunit floating drug delivery system of rosiglitazone maleate has been

developed by encapsulating the drug into Eudragit RS100 through nonaqueous
emulsification/solvent evaporation method. The in vitro performances of
microspheres were evaluated by yield (%), particle size analysis, drug entrapment
efficiency, in vitro floating behavior, surface topography, drug-polymer
compatibility, crystallinity of the drug in the microspheres, and drug release
studies. In vitro release was optimized by a {3, 3} simplex lattice mixture
design to achieve predetermined target release. The in vivo performance of the
optimized formulation was evaluated in streptozotocin-induced diabetic rats. The
results showed that floating microspheres could be successfully prepared with
good yields (69-75%), high entrapment (78-97%), narrow size distribution, and
desired target release with the help of statistical design of experiments from
Recent advances in the treatment of Chagas disease have followed combinations of
drugs that act synergistically against infection, predominantly including
benznidazole (BNZ) and azoles derivatives. Possible incompatibilities between
these drugs, slow dissolution of BNZ and dose adjustment difficulties are
technological obstacles to the development of multidrug formulations. Thus, in
the present study, BNZ pellets were developed using extrusion spheronization for
immediate drug delivery. Preformulation studies were then performed using thermal
analysis and infrared spectroscopy and compatibility between the drug and
selected excipients (polyethylene glycol 6000, sodium starch glycolate,
microcrystalline cellulose and sodium croscarmellose) was investigated. No
chemical decomposition of BNZ was observed, even in samples submitted to wet
granulation and thermal stress. Subsequently, formulations were elaborated
according to a simplex lattice experimental design using polyethylene glycol,
sodium starch glycolate and sodium croscarmellose as disintegrating agents. In
these experiments, BNZ pellets showed appropriate physicochemical
characteristics, including high drug load capacity and excellent flow properties.
The mixture experimental design allowed identification of adequate compositions
of disintegrating agents and achieved rapid disintegration and dissolution of
pellets. Optimum performance was achieved using polyethylene glycol and sodium
croscarmellose at 5.0% w/w each. The present BNZ pellets are versatile
alternatives to treat Chagas disease and provide insights into the preparation of
multidrug systems.
Aminated starch coated iron oxide magnetic nanoparticles loaded with curcumin
were synthesized via coprecipitation technique. The nanoparticles were
crosslinked by using three different crosslinkers: glutaraldehyde, genipin and
citric acid and the effect of crosslinking on different properties of the
nanoparticles was evaluated. Characterisation of the nanoparticles was done with
FTIR (Fourier Transform Infrared spectroscopy) and XRD (X-Ray Diffraction).
Magnetic property study using VSM (Vibrating Sample Magnetometer) showed their
superparamagnetic nature. Morphology of the nanoparticles was studied by SEM
(Scanning Electron Microscopy) and TEM (Transmission Electron Microscopy). Zeta
potential values showed that crosslinking imparted stability to the system.
Crosslinking also enhanced drug loading and encapsulation efficiency of the
system. Swelling and in vitro studies of the nanoparticles showed that the
release of drug was dependent on time, crosslinker nature, crosslinker
concentration and pH of the medium. The aminated starch coated nanoparticles also
showed good mucoadhesive character. The cell viability assessment by MTT study
revealed their compatibility with human lymphocytes cells and their considerable
cell growth inhibiting properties with MCF7 and HepG2 cells. The nanoparticles
showed good internalization in HepG2 cells along with considerable ROS formation.
determination and pharmacokinetic investigation of Tetramethylpyrazine (TMP) and
Ferulic acid (FA) in rat striatum. The method was validated over the
concentration range of 1.15-505ng/mL for TMP and 3.23-101ng/mL for FA, with a
lower limit of quantitation (LLOQ) of 1.15ng/mL and 3.23ng/mL, respectively. This
method can be successfully applied in pharmacokinetic studies of TMP and FA in
striatum of awake and anesthetic rats. The cerebral blood flow velocity (CBF)
during middle cerebral artery occlusion (MCAO) was monitored by Laser speckle
contrast imaging, to observe whether the compatibility of TMP and FA could
improve CBF against cerebral ischemia/reperfusion (I/R) injury. Infarct volume
was examined to evaluate severity of ischemic brain injury. The pharmacokinetic
study indicated that T1/2, Cmax, MRT and AUC0-inf were changed after combined
administration of TMP and FA, when compared with either drug alone both in awake
and anesthetic groups. The pharmacodynamics results showed that co-administration
of drugs could enhance the CBF during middle cerebral artery occlusion and
reduced the infarct volume.
Resveratrol-phospholipid complex Taken together, the (RSVP)
(Phytosome(R)) compatibility
was found treatmentbetterof TMP
aqueous
and FA might be a promising therapeutic strategy
soluble and permeable than free resveratrol (RSV). RSVPs were incorporated in for ischemic stroke. Further
study is required to optimize by the compatibility proportion.
Thepolymeric patch prepared
low bioavailability and consequently solvent casting
the poor method using response
therapeutic Eudragit RL of 100, PVP
K30, and PEG
traditional 400 for application
ophthalmic formulations on isdermal
caused sites for sustained
by reduced treating
pre-corneal of
residence
inflammation.
time of the formulation Prepared in patches
contact were
withevaluated
the ocularfor variousThe
surface. physicochemical
use of colloidal
properties,
carrier systems, surface morphology
namely by SEM, TEM,
lipid nanoparticles and compatibility
in combination with inofsitu patch components
gelling
by
polymers, is an excellent strategy which results in the exponential increasedrug
FT-IR and DSC studies. Optimized formulation (F9) gave 95.79 +/- 3.02% of
release
the and chromatographic
51.36%of
bioavailability
A mixed-mode (4.28 +/- 0.48
ophthalmic mg/cm(2))
drugs.material,
packing In the skin permeation
present
C18 and study, after
we have
diol groups 24modified
h.developed
Skin
extract
silica when examined
thermoresponsive
(C18-Diol), was eyedrops
preparedfor drug accumulation
prepared
with showed
with nanostructured
controllable 38.31lipid
hydrophobicity +/- and
2.42%
carriers drug content.
(NLC)
FE-SEM images
dispersions forItthe
hydrophilicity. of the patch taken
controlled delivery
demonstrated after
excellent drug
of ibuprofen.release and skin
Lipid solubility
aqueous compatibility permeation
andstudies studies
stability in
showed
and DSC that
aqueous mobileRSVPs
measurementsphase;in polymeric
have proved
compared patch
to the are
that stable
the lipids
traditional and retain
solubilise
C18 column, their structure
ibuprofen
improved after
andpeak
present
shape
a24 h long
good exposure
compatibility. to physiologic
NLC were environment.
prepared
of basic analytes was also obtained. Additionally, it exhibited both based Sustained
on the anti-inflammatory
melt-emulsification andeffect
was establishedtechnique
ultrasonication
reversed-phase in carrageenan-induced
liquid and lipid nanoparticles
chromatographic paw edema
(RPLC) and with model in which
a Z-average
hydrophilic oftest formulation
120-150
interaction nm,
gave 84.10% inhibition
polydispersity index
chromatographic of
below
(HILIC) inflammation
0.3, highly positive
performance; at 24 h
the analyte as compared
zeta potential
separationandto 39.58%
scope wasstandard
for
an efficacy thusof
diclofenac
encapsulation
enlarged, sodiumof ~87%
demonstrated gel. were
The byCLSM
obtained.studyThe
simultaneous confirmed
cytotoxicity
separation theoflocalization
of NLC was
twenty of
acids, RSVPs
bases for
evaluated byathe
and
longer period,
Alamar
neutrals. Blue
More thus
reduction enabling
interestingly,assay drugusing
a novel targeting
the Y-79 human
on-line to the dermis for liquid
retinoblastoma
two-dimensional sustained effect.
cell line, and no
Skin irritation
relevant
chromatographytoxicitytestwas
ononthe rabbit
observed
singlerevealed that
after exposure
column the patches
(2D-LC-1C) to 0-100 are safe for
mug/mL
was established NLC skin
by for up to 72the
modifying
application.
hours.
high performanceHistological
The HET-CAM assay
liquid observations
was used to assess
chromatographic suggested that
the product
instrument after exposure
eye compatibility,
only with to the of an
the addition
permeants,
confirming
extra six-port the
that SC
theintegrity
developed
two-position hadproduct
valve. not
Thealtereddoes
early and
notno
co-eluted evidence
exhibit irritant
components of presence
potential. of
The in
of the extract
inflammatory
vitro
of Lonicera cells found.
releasejaponica
studies on theRSVP
showed (Phytosome(R))
ibuprofen
1st-dimension release
(RPLC) containing
overwereseveral patches
collectedhours. abled
for the to give
online
sustained
re-injectiontherapeutic effect that may
to the 2nd-dimension (HILIC)be useful in treatingvarying
by conveniently acute and the chronic
mobile
inflammation.
phase components. Six more peaks were obtained. The established system was
Exploring
simple, drug molecules and
easy operation for material
low cost,design, which to hadharness
advantagesconcepts of
in analyzing
nano-anisotropy
complicated samples. and ligand-receptor interactions, are rather elusive. The aim of
this study is to demonstrate the bottom-up design of a single-step and
bio-interactive polymeric surface coating, based on drug based pendant polymer.
This can be applied on to polystyrene (PS) substrates, to suppress macrophage
Remifentanil
adhesion and is a mu-opioid
spreading. receptor The drugagonist molecule that was developed
is used in this coating as a for two
synthetic opioid for use in anesthesia and intensive
purposes. The first one is drug as a "pendant" group, to produce nano-anisotropic care medicine. Remifentanil
is rapidly metabolized in both blood and tissues,
properties that can enable adhesion of the coatings to the substrate. The which results in a very short
second
duration of action. Even after blood sampling, remifentanil
purpose is to use the drug as a "ligand", to produce ligand-receptor interaction, is unstable in whole
blood
between andthe plasma
bound through
ligand endogenous
and receptorsesterases of albumin, andtochemical
develophydrolysis.
a self-albumin The coat
instability of remifentanil in these matrices
over the surface, by the preferential binding of albumin in biological makes sample collection and
processing
environment, a critical
to reduce phase in the bioanalysis
macrophage adhesion. of remifentanil.
Our in silico studiesMETHODS: showWe have
that,
developed a fast and simple sample preparation
diclofenac (DIC) is an ideal drug based "ligand" for albumin. This can also act method using protein precipitation
followed
as a "pendant" by liquid chromatography-tandem
group with planar aryl groups. massThespectrometry
combination of analysis.
these two To improve
the stability of remifentanil, citric acid, ascorbic
factors can help to harness, both nano-anisotropic properties and biological acid, and formic acid were
investigated
functions to the for acidification
polymeric coating. of EDTA plasma.
Further, theThe stability
drug, of remifentanil
diclofenac (DIC) is was
investigated in stock solution, EDTA whole blood,
immobilized to the polyvinyl alcohol (PVA), to develop the pendant polymer EDTA plasma, and acidified EDTA
plasma at ambient temperature, 4 degrees C,
(PVA-DIC). The interaction of bound DIC with the albumin is a ligand-receptor 0 degrees C, and at -20 degrees C.
RESULTS:
based interaction, as per the studies by circular dichroism, differential and Drug
The analytical method was fully validated based on the Food
Administration
scanning calorimetry, guidelines and for bioanalytical
SDS-PAGE. method validation
The non-polar with a large
pi-pi* interactions are linear
range of 0.20 to 250 ng/mL remifentanil in EDTA
regulating; the interactions between PVA bound DIC-DIC interactions, leading to plasma acidified with formic
acid. The stability results
"nano-anisotropic of remifentanil
condensation" to formindistinct
EDTA tubes, containing whole
"nano-anisotropic blood
segments"
placed in ice water, showed a decrease of approximately
inside the polymeric coating. This is evident from, the thermo-responsiveness and 2% in 2 hours. EDTA
plasma
uniformacidified with citric acid,
size of nanoparticles, asformic
well asacid, regular androughness
ascorbic acid in the showedsurface 0.5%,
4.2%, and 7.2% remifentanil degradation, respectively,
coating, with similar properties as that of nanoparticles. In addition, the after 19 hours at ambient
temperature. Formic acid was(PS)
hydrophobic DIC-polystyrene chosen because of
interactions, its volatility
between and thuscoating
the PVA-DIC liquid and
chromatography-tandem mass spectrometry compatibility.
PS-substrate produce improved coating stability. Subsequently, the PVA-DIC coated The use of formic acid
added to EDTA plasma improved the stability
substrate has the maximum capacity to suppress the macrophage (RAW 264.7 cellof remifentanil, which was stable for
2line)
days at ambient temperature, 14 days at 4 degrees
adhesion and spreading, which is partly due to wavy-surface topography of C, and 103 days at -20
degrees
hydrophilic C. CONCLUSIONS:
PVA and preferential The analytical
albumin method we developed
binding capacity of PVAuses bound a simple
DIC. Ourprotein
precipitation and maximal throughput by a 2-point
result shows that, such surfaces suppress the macrophages, even under stimulation calibration curve and short run
times of 2.6 minutes. Best sample stability is obtained
with lipopolysaccharide (LPS). The modified tissue culture plates can be used as by placing tubes
containing EDTAtowhole
an in vitro tool, studyblood in ice waterresponse
the macrophage directly after under sampling,
low spatial followed
cues. by
centrifugation and transfer of the EDTA plasma to tubes with formic acid. The
stability of remifentanil in EDTA plasma was significantly improved by the
addition of 1.5 muL formic acid per milliliter of EDTA plasma. This analytical
method and sample pretreatment are suitable for remifentanil pharmacokinetic
studies.
The use of chemical penetration enhancers (CPEs) is one of the most common
approaches to improve the dermal and transdermal delivery of drugs. However,
often, incorporation of CPEs in the formulation poses compatibility and stability
challenges. Moreover, incorporation of enhancers in the formulation leads to
prolonged exposure to skin increasing the concern of causing skin reactions. This
study was undertaken to assess whether pretreatment with CPEs is a rational
approach to enhance the permeation of diclofenac sodium. In vitro experiments
were performed across porcine epidermis pretreated with propylene glycol or oleic
acid or their combinations for 0.5, 2, and 4 h, respectively. Pretreatment with
combination of oleic acid in propylene glycol was found to enhance the permeation
of diclofenac sodium significantly only at 10% and 20% (v/v) level, and only when
the pretreatment duration was 0.5 h. Longer durations of pretreatment and higher
concentration of oleic acid in propylene glycol did not enhance the permeation of
diclofenac sodium. In vivo dermatokinetic studies were carried out on
Sprague-Dawley rats. A twofold increase in AUC and Cmax was observed in case of
rats pretreated with enhancers over the group that was pretreated with buffer. In
conclusion, this study showed that composition of the enhancers and duration of
Thepretreatment
excessive andare crucial in determining
continuously growing interest the efficacy
in the of CPEs.
simultaneous determination
of poppy alkaloids imposes the development and optimization of convenient
high-throughput methods for the assessment of the qualitative and quantitative
profile of alkaloids in poppy straw. Systematic optimization of two
chromatographic methods (gas chromatography (GC)/flame ionization detector
(FID)/mass spectrometry (MS) and reversed-phase (RP)-high-performance liquid
To improve the poor(HPLC)/diode
chromatography compatibility array among different
detector components
(DAD)) of Drug-in-adhesive
for the separation of alkaloids
type patch,
from Papaver two novel plasters
somniferum (Drug-in-fiber and
L. (Papaveraceae) wasDrug-in-adhesive/fiber)
carried out. The effectswere of various
developed
conditions on basedthe on ibuprofenchromatographic
predefined (IBU)-loaded fiber mats. These
descriptors werefibrous mats were
investigated using
fabricated
chemometrics. via electrospinning
A full factorial linear of cellulose
designacetate/poly(vinylpyrrolidone)
of experiments for determining the
composites
relationship in a binarychromatographic
between solvent of N,N-dimethyl conditions acetamide/acetone.
and the retentionPhysical behavior status
of the
studies suggested
analytes was used.that Drug-in-fiber
Central compositecould inhibit IBUdesign
circumscribed re-crystallization,
was utilizedbut for the
the
finalactive
method ingredients
optimization. wereBy released
conducting at a relatively slow rateofdue
the optimization theto the
methods in very
dual-resistance of fiber mat and adhesive matrix.
rational manner, a great deal of excessive and unproductive laboratory research To overcome this shortcoming,
Drug-in-adhesive/fiber
work was avoided. Thewas designed
developed by coupling medicated
chromatographic methods hydrophilic
were validated pressure and
sensitive adhesive
Microspheres
compared ofline
in tramadolandthe
with IBU-loaded
resolvingfiber
hydrochloride mat.sensitivity,
(TM)
power, forThis
oralmethod
delivery endowed
accuracy,werespeed,
prepared cost,by
Drug-in-adhesive/fiber
complex aspects, andamethod
ecologicalcoacervation fast IBU
compatibility release
without with rate
the use
the and ofhigh
poppy permeated
chemical
straw drugprocedure.
cross-linking
extraction amount
agents such
though
The separation of the opium alkaloids using the GC/FID/MS method was matrix,
as simulative
glutaraldehyde skins.
to avoidThis thedesign
toxic separated
reactions enhancer
and other from adhesive
undesirable effects of
achieved
which
the guaranteed
chemical Drug-in-adhesive/fiber
cross-linking agents. excellent
Alternatively,
within 10 min, avoiding any derivatization step. This method has a stronger adhesion
ionotropic forces.
gelation Hence,
was the
plasters based
employed
resolving by using
power, onshorter
medicated fibertime,
sodium-tripolyphosphate
analysis matsbetter
improved as the compatibility
cross-linking
cost/effectiveness agent.
factor among thanpatch
Chitosan and
the
components.
gelatin B weremethod
RP-HPLC/DAD used as and polymer and with
is in line copolymer,
the "green respectively.
trend" ofAll thethe prepared
analysis. The
microspheres
RP-HPLC/DAD were method subjected
on the other to varioushandphysicochemical
displayed betterstudies, sensitivity such forasall tested
drug-polymer compatibility by thin layer chromatography
alkaloids. The proposed methods provide both fast screening and an accurate (TLC) and Fourier
transform infrared (FTIR)
content assessment of thespectroscopy,
six alkaloids insurface the poppy morphology
samples by scanning
obtained fromelectron
the
microscopy,
selection program frequency distribution,
of Papaver strains. drug entrapment efficiency, in vitro drug
release characteristics and release kinetics. The physical state of drug in the
microspheres was determined by differential scanning calorimetry (DSC) and X-ray
diffractometry (XRD). TLC and FTIR studies indicated no drug-polymer
incompatibility. All the microspheres showed initial burst release followed by a
Thefickian
aim ofdiffusion
this study was to produce
mechanism. DSC and hydrogels
XRD analysisfor topical use and
indicated thathaving
the TM trapped
strengthened anti-inflammatory, analgesic
in the microspheres existed in an amorphous or disordered-crystalline and antirheumatic activity. To obtain
status in
the above
BACKGROUND effect
the polymer AND matrix.dry standardized
OBJECTIVE:
From theAdministering plant extract
preliminary trials, variouswas
it was added to
combinations enrich
observed that a formulation
of acetaminophen,
it may be
containing
possible to therapeutic
ketoprofen, nefopam TM
formulate agent
and (ketoprofen)
ketamine,
microspheres though from
by using the
sometimes group of nonsteroidal
discussed,
biodegradable naturalis expected
polymers to
anti-inflammatory
provide
such as superior
chitosan anddrugs.
pain relief
gelatinDry and
B standardized
toreduce
overcome opioid extract
the from Solidago
analgesic-related
drawbacks of TM virgaurea
side
and effects. L. of
to increase
Combination
confirmed of drugs for
anti-inflammatory subcutaneousactivity was infusion is
selected common
for this practice
purpose. in The
However,
the patient
palliative some studies
compliance.
medicine, have indicated
however, there (Carbopol
is nothat multimodal
information analgesia
pertaining tohas thelimited
derivatives
efficacy. of acrylic
We studied acid polymers
the stability of various Ultrez and
binaryincombinations Carbopol 980)
of these were
four used
compatibility
as the formulation and stability
vehicles. ofThese
tramadol combined
vehicles were ternaryowing
selected admixtures
to their and
high no
drugs. PATIENTS
information existsAND METHODS:
regarding The drugs
its clinical were studied
performance. at 25 degrees
METHODS: Tramadol C. Binary
applicative
mixtures ofproperties--transparency,
acetaminophen, ketoprofen, resistance
nefopam to changes
and ketamine of temperature,
were produced. Each
hydrochloride,
perfect haloperidol
tactile and esthetic lactate,
qualities, and hyoscine
no asensitizing N-butyl bromide
agents, no toxicity have been
and
drug concentration
examined was
for compatibility assessed using
and stability specific
when high-performance
combined in solution liquid
under
lack of influence
chromatographic on therapeutic
technique. properties
Measurements ofwere
the therapeutic
carried out agent
at T0,in+1,and+2, +4, +6
conditions
compatibility mimicking
in the their potential
pharmaceutical use
phase. via subcutaneous
The produced infusion
formulations terminal
were exposed
and +24 h.patients.
oncology A 5% lossConcentration
of initial concentrationranges was8.8-33.3
were considered mg/mL, to be significant.
0.208-0.624 mg/mL,
to
The basic physicochemical
changes with time of tests--pH,
the viscosity parameters
concentrations were analysed(structural
using viscosity,
linear regression
and
yield 3.33-6.67
stress mg/mL for tramadol hydrochloride, haloperidol lactate, and hyoscine
analysis.
N-butyl A Pand
bromide.valuethixotropy),
of less
With than
these,
pharmaceutical
270.05different
availability
was significant.
admixtures
and durability
RESULTS:
were The four
prepared and
after
drugs
stored
six months
tested in the of storage.
binary The
mixtures effect
were of component
stable,Quantification plant
showing neither extractsloss on the process
of concentration ofat
25 degrees
ketoprofen C using
diffusion 0.9% saline
to acceptor as diluent. was performed by
nor degradation
high-performance products (P > or fluid
liquid chromatography
through
= 0.05). a semipermeable
CONCLUSION:
(HPLC).
membrane
Physicochemical
The clinical performance
was also
negative
compared.
interaction The
is not obtained
likely to results
account indicate
for the that dry clinical
limited standardized
efficacy extract
sometimes fromof the
admixture
Solidago was retrospectively
virgaurea L. combinations
does not affect assessed in 28 terminal oncology of patients
reported
exhibiting with binary
Karnofsky's indexes of ofsignificantly
these
10%-20%. drugs.the
RESULTS:
process
Coadministration
All three
ketoprofen
drugs of binary
were very
release
mixtures from the tested
of acetaminophen, preparations.
nefopam, After six
ketoprofen months of storage
and ketamine the
from theinsame bottle
stable (>92%)
preparations at
with 25 degrees
ketoprofen C for 15 days.
demonstrate Pain was completely controlled high all
or infusion
patients. bag
Fifty using
percent the
of same
the patients line isrheological
venoussuffered demonstrated
from 3-5
stability
vomitingto beandfeasible.
episodes per
pharmaceutical availability.
day and of these, 75% experienced complete control of the episodes. None of the
patients showed local reactions after subcutaneous administration of the
admixture. RESULTS: Our results confirm the compatibility and stability of the
ternary admixture and its utility in highly vulnerable patients exhibiting
moderate symptoms.
The purpose of this research was to develop a matrix-type transdermal therapeutic
system containing herbal drug, curcumin (CUR), with different ratios of
hydrophilic (hydroxyl propyl methyl cellulose K4M [HPMC K4M]) and hydrophobic
(ethyl cellulose [EC]) polymeric systems by the solvent evaporation technique.
Different concentrations of oleic acid (OA) were used to enhance the transdermal
An permeation
application of of carboxymethyl
CUR. The physicochemical mungbean starch (CMMS)ofasthe
compatibility a gelling
drug and agentthein the
polymers
topical pharmaceutical preparation was investigated.
was also studied by differential scanning calorimetry (DSC) and infrared (IR) CMMS was prepared using
Thespecific conditions
use of microthermal
spectroscopy. that
The results yielded
analysis asa ahigh-viscosity
suggested novel meansproduct.
of assessing
no physicochemical Polymer gels andbetween
chemical
incompatibility gel
bases were
incompatibility
the drug and the prepared
between at
polymers. 1-10%
drugs (wt/wt), and
and excipients
Formulated physicochemical
is assessed
transdermal studies
films using
were magnesiumwere carried
stearate
physically evaluated
out in comparison with four standard gelling agents: carbopol 940thickness,
(CP),analysis
An and
with acetylsalicylic
regard
automated to drug
solid-phase
hydroxypropylmethyl
acid as
content,a model
tensile
extraction
cellulosethermal
system.
strength,
procedure
(HPMC),
Localised
methyl
foldingthermomechanical
combined endurance,
cellulose with
(MC), gasand sodium
and
(L-TMA), localisedAll
weight variation.
chromatography-mass differential
prepared
spectrometryformulations analysis (L-DTA),
indicated
methodology, nanosampling,
good
without physical thermally
stability.
derivatization, In been
has
carboxymethyl
assisted
vitro particle
permeation cellulose
manipulation
studies (SCMC). (TAPM)Piroxicam
of formulations and wasperformed
used as amicrospectrometry
photothermal
were model
by using drug to study
Franz the
(PTMS)
diffusion
developed
drug release for the
profile identification
of the gel and quantitation
formulations. The of ketamine,
tackless, norketamine,
greaseless, and
are developed
cells. The results
tramadol, asfollowed
methadone, a means of allowing
Higuchi extremely
kinetics, and the small quantitiesofofrelease
mechanism
2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, drug andand
was
transparent
excipient to CMMS
be heated
diffusion-mediated. gelsinexhibited pseudoplastic
close proximity
Formulation prepared towith
each behavior
other.
hydrophilic with thixotropy
Differential
polymer scanning at
containing
2-ethyl-5-methyl-3,3-diphenylpyrroline
concentrations less than 5% (wt/wt). Atina urine. The
concentration analytical
of 5% approach
(wt/wt) is
and higher,
calorimetry
permeation
simple (DSC),
enhancer
and rapid, yethot stage
showedGood
reliable. microscopy
best in (HSM)
vitro skin
linearity (r(2) and temperature
permeation
> 0.995 through
over the controlled
rat skin as
the semisolid
attenuated
compared with gels
total showed
allinternal
other plastic flow
reflection
formulations. (ATR)characteristics.
This FTIR were used
formulation Viscosity and X-ray
asofsupportive
demonstrated good
concentration
diffraction results range of
indicated30 to 600 ng/mL), sensitivity
a goodcarrageenan-induced
compatibility (limits
between quantitation
CMMSinand the acidic
techniques.
anti-inflammatory
15-30 ng/mL), L-TMA
accuracy and macroscopic
activity against
(81.0-109.9%), TMA of
precision magnesium
(RSD stearate
oedema
< 13.8%), and indicated
Wistar
recovery that the
albino
(>
piroxicam.
endothermic
rats similar No
toDSC precipitation
standardpeak normally of piroxicam
formulation. associated or phase separation
with Ninety-one
melting does was observed
notspecimens
correspond during
to
79.6% in average)
a stability test. were
The release achieved
rate for all
of piroxicamanalytes.from 3% (wt/wt)the urine
CMMS gel wasatfrom
significant
suspected liquefaction.
drug users andAn 21optimised
clinical method
urine for
specimens detecting
from interaction
methadone a
substitution
1,003.79
particulate +/- level
105.08 of microg/cm(2),
scrutiny was to which waswhereby
developed comparable with is947.66
thecompatibility
drug placed +/-on133.70
the
therapy patients
microg/cm(2) were
obtained analyzed
from a 0.5% validate
(wt/wt) the method
carbopol formulation. The and
release
excipient
stability. surface
Results via TAPM
have demonstrated and the construct heated,
that this GC-MS allowing is a good after 2to
the
methodunchanged interaction
profiles
be detectedof bothinand formulations
both the L-TMA wereand consistent
L-DTA signal. andPTMS
remainedallowed spectra toinbe
confirmation
months' quantitation test scheme for the six target compounds urine.
obtainedstorage. Viscosity played
on nanogram-sized samples an important role in controlling
and also allowed the release
the interaction to be
rate of lowThe
detected. concentration
study has therefore CMMS formulations
demonstrated by the
regulating
potentialthefordrug diffusion.
using TAPM withAt
aPTMS
concentration of 5% (wt/wt) CMMS and
for studying interactions at an individual particle level. higher, the release rates of piroxicam
were not significantly different. A plausible explanation based on the nature of
the gelling agent was proposed. Stability and drug release profiles of CMMS and
commercial gelling agents were compared. The results supported the potential use
of CMMS as a new, effective gelling agent for topical gel preparation.
Two crystalline forms of tasimelteon, a drug approved by the U.S. Food and Drug Administration for the treatment of n
methods. The synthetic method forming tasimelteon is described in detail, with its full analytical, spectroscopic, and en
solved and refined in the P43212 space group, showing the occurrence of polymeric (H-bonded) slabs, thanks to the pr
monoclinic P21 space group, with a = 11.130(4), b = 4.907(2), c = 12.230(6) Å, β = 91.03(3)°, V = 667.8(5) Å3; Z = 2. Thanks
interactions between (translationally related) tasimelteon molecules, forming, in the crystal, well-defined chains runnin
determined crystal structures enable the successful usage of full-pattern matching X-ray-based quantitative analyses o
Thermal analysis has been widely used for obtaining information about drug–polymer interactions and for pre-formula
were produced by spray drying. The main purpose of this study was to study the effect of the spray-drying process not
(DTG), X-ray analysis (XRD), and infrared spectroscopy (IR). The evaluation of drug–polymer interactions and the pre-fo
showed high levels of drug-loading efficiency for all used drug:polymer ratio, and the polymorph used for preparing th
between drug content and the structural and thermal properties of drug-loaded PLGA microparticles was established.
demonstrating that no significant chemical interaction occurs between TR and PLGA in both physical mixtures and mic
drug also present in the TR-loaded microparticles. From the pre-formulation studies, we have found that the spray-dry
Stability of enalapril maleate formulations can be affected when the product is exposed to higher temperature and hum
(reference, generic and similar products) were evaluated. After 180 days of the accelerated stability testing, most prod
drug concentration and drug release profile of enalapril formulations are strong indicators of a compromised bioavaila
The aim of this study was to design and synthesize pharmaceutical agents containing imidazolidine heterocyclic ring in
and aromatic aldehydes. The imidazolidine derivatives (3a–k) were investigated for their anticipated anti-inflammatory
by online computer software programs viz. Molinspiration and Osiris property explorer. The results of biological testin
4-methoxybenzyl)-2-imidazolidinyl]phenyl-diethylamine (3i) and 4-(1,3-Bis(4-methoxybenzyl)-4-methylimidazolidin-2-yl)
the positive
Three novel control,
amino acidIndomethacin. Allamphiphilic
based anionic synthesizedcopolymers
compoundspoly(sodium
showed promising bioactivity score for drug targets(w
N-acryloyl-l-valinate-co-alkylacrylamide) by
further research
self-assemble as it obeyed
in aqueous Lipinski’s
solution ruleinter-chain
through of five for drug likeness,aggregation,
hydrophobic exhibited promising
formingbiological activity
micelle-like in-vivohavin
aggregates and s
temperature. The polymeric micelles were observed to be stable under biological conditions (pH 7.4, [NaCl] = 150 mM a
upon the hydrophobicity the solubilities of the drugs were observed to increase ca. 2–10 times in the presence of 1.0 g/
cytotoxicity studies were carried out using hemolytic and MTT assay, respectively. The anionic HMPs were found to be
The purpose of this study was to develop transdermal films (TFs) with the addition of different polymer ratios that inco
treatment of rheumatic diseases and characterized by its efficacy and reduced side effects in comparison to other NSA
Estimation of drug–excipient interactions is a crucial step in preformulation studies of drug development to achieve co
FT-IR, solid state NMR and PXRD into pre-formulation studies have contributed significantly to early prediction, monito
required to arrive at an appropriate formulation. Concomitant use of several thermal and spectroscopic techniques allo
focuses on the techniques for compatibility screening of active pharmaceutical ingredient with their potential merits a
This study compared two specific embodiments of an ocular nanosystem (NS): one portraying a purely polymeric syste
poly(ε-caprolactone) nanosystem. Investigations undertaken were implicit to warrant inclusion in an implantable syste
terms of tissue permeation, cell uptake, and anti-inflammatory activity. Furthermore, the size (134.3 vs. 140.7 nm); surfa
antiinflammatory efficacy, demonstrated by a decrease in 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole complex formation (0
fluorescence
Curcumin andand emuconfocal microscopy,
oil derived from emuallbird
highlighted
(Dromaiusthe enhanced potential
novaehollandiae) has of the lipoidal
shown system
promising compared
results against with the
inflamm
balance
Hence, the current investigation was designed to evaluate the anti-inflammatory potential of curcumin in combinationP
of the composite NS compared with the purely polymeric NS. © 2013 Wiley Periodicals, Inc. and the American
as oil phase, surfactant and co-surfactant. The optimized curcumin loaded nanoemulsion with emu oil was incorporate
terms of paw swelling, weight indices of the liver and spleen, pathological changes in nuclear factor kappa B, iNOS, CO
inflammatory activity with formulations containing curcumin in combination with emu oil compared to pure curcumin.
The main purpose of this study is to prepare highly stable diclofenac potassium (DP) pellet with microcrystalline cellulo
Chromatography (HPLC). After stability test of 60 °C/75% RH for 10 d, the values of two main related compounds were 0
investigated. Upon addition of 1.5% (w/w) sodium hydroxide, the primary related compound of pellets was reduced to
hydroxide. The mechanisms were discussed and residual hydroxyl free radicals in excipients were responsible for deco
The aim of the present study was to evaluate the funtion of fenugreek seed mucilage (FSM) as potential matrix formin
Oral lyophilisates (OLs) with different FSM concentrations, containing meloxicam as model drug were prepared by free
Based on colloidal dispersions' rheological properties, five FSM concentrations were taken forward to the lyophilizatio
All the prepared tablets disintegrated in less than 47 s. The disintegration process was prolonged by the increase in FSM
strength. Considering the fast disintegration and the high crushing strength, FSM is a good candidate as matrix formin
Poloxamer gels are conventionally prepared by the “hot” or the “cold” process. But these techniques have some disad
extrusion technology. The model drug selected was ketoprofen. The formulations developed were 30% and 40% poloxa
the permeation studies that with increasing poloxamer concentration, a decrease in drug permeation was obtained. O
could be successfully employed to develop poloxamer gels by overcoming the drawbacks associated with the convent
This unique work is targeted to achieve three main goals: i) to enhance the aqueous solubility of three specifically selec
textile with active loaded microparticles and active-cyclodextrin loaded microparticles. To achieve this objective, biode
α-tocopheroland Lauryl Isoquinolinium Bromide during the formulation process. Inclusion complex based particles we
encapsulation do not affect the morphology, size and zeta potential of the microparticles as well as adsorption of the m
and also provided prolonged release formulations.
In the present study, we designed and synthesized a hydrogelator comprised of ibuprofen (IPF) and GFFY peptide linke
acted upon by an esterase, IPF was released in a sustained manner. Moreover, the hydrogel had significantly elevated
In vivo results further demonstrated that the hydrogel had therapeutic efficacy comparable to that of a current treatm
developing supramolecular assemblies as anti-inflammatory ophthalmic therapeutics for eye disorders.
Drug delivery via the nasal route is gaining increasing interest over the last two decades as an alternative to oral or par
was carried out using “analgesic agents” as an example. Four such drug candidates (rizatriptan, meloxicam, lornoxicam
Calu-3 cell line model. Based on the in vitro screening results and the reported pharmacokinetic and the stability data, m
meloxicam was comparable to its intravenous administration, with respect to plasma drug concentration and AUC0–2
bethis
In capable
studyofthe
developing
significant“analgesic agents” suitable
effect of chitosan for nasal
on improving the delivery. Further
dissolution studies
rate and are neededoftoaceclofenac
bioavailability prove the clinica
has b
crystals with different concentrations of chitosan (0.05–0.6%) were characterized in terms of solubility, drug content, p
The in vivo performance was assessed by preclinical pharmacodynamic (analgesic and anti-inflammatory activity) and p
disorder in the crystalline content. The XRD also revealed a characteristic decrease in crystallinity. The dissolution studi
formulation was attributed to the wetting effect of chitosan, decreased drug crystallinity, altered surface morphology
rapid pharmacological response in mice and rats besides exhibiting improved pharmacokinetic parameters in rats.
The motive behind present work was to formulate and evaluate gel containing microsponges of diclofenac diethylamin
ratios were prepared. For the sake of optimization, diverse factors affecting microparticles physical properties were to
as well. There were no chemical interactions between drug and polymers used as revealed by compatibility studies out
had 7.21 μm mean particle size. The microsponges were then incorporated in gel; which exhibited viscous modulus alon
of
The8 study
h; while conventional
investigated formulation
usage getof
of hydrogel exhausted
an anionicincredibly earlier bygum
polymer xanthan releasing 81.11%ofdrug
for design at the end of 4hydrogel-
ibuprofen-loaded h only. T
musculoskeletal disorders.
°C, 20 ± 3 °C, and 40 ± 1 °C during 6 months. The results of physicochemical characterization (pH, conductivity, rheologic
aqueous phase thickened with the polymer gel network which strength depended on the polymer concentration. HTM
hydrogel was described by Higuchi model. The HTM with optimized drug release rate and spreadability (HTM1) and the
Ibuprofen
in producing was recrystallized inand
antihyperalgesic theat
presence of aqueous
lower extent solution of
antiedematous cationic
activity dextran derivative,
in prophylactic topicalDiethylaminoethyl
treatment protocol, Dexw
thermo-analytical characteristics without the use of organic solvent. Ddex was used in this study because of its ability t
Mechanism of conjugation as well as the impact of conjugation on the ibuprofen crystal habit was investigated. Gaussi
480 nm (440-folds reduction, p < 0.05, n = 20) at Ddex molar concentration of 0.01 mM. FT-IR spectra showed electr
ibuprofen–Ddex conjugate crystanules suggesting compatibility and formation of an eutectic product. The conjugate c
respectively
The successful confirming
design andthedevelopment
existence of of
ibuprofen–Ddex
pharmaceuticalcrystanule conjugates
drug–polymer in amorphous
composites requires state. Higher
detailed concentrat
information ab
concentration
Ketoprofen of the
(KET) andcrystanules while higher
the bio-compatible and concentrations exhibitedpoly(lactic-co-glycolic)
biodegradable polymer second order degradation profile.
acid 5050 This study
(PLGA). pr
Equilib
of emulsions (SFEE). The influence of temperature was studied in the range between 0 °C and 50 °C, while the effect of
the level of KET established in PLGA at equilibrium increases with temperature, e.g. from 6.9 wt.% at 20 °C to 25.8 wt.%
highest for simultaneous equilibration with both crystalline species. Experimental solubility data of KET in PLGA were a
equilibration period, presumably because the polymer phase had undergone a transition into the glassy state. For this
In this study, a bi-layer osmotic pump tablet (OPT) of Flurbiprofen (FP) solid dispersions (SDs) was developed to increa
the solubility parameters, the FP-SD was prepared by hot melt extrusion (HME) technique with the carrier of PVPVA64
carrier for preparing FP-SD. The results of DSC and X-Ray confirmed that FP in FP-SD was in amorphous state. FTIR indic
mathematical models had good predictability because of the deviation was less than 1% between predicted value and m
We describe formulation and evaluation of novel dissolving polymeric microneedle (MN) arrays for the facilitated deliv
poly(methylvinylether/maleic acid). These MNs were robust and effectively penetrated skin in vitro, dissolving rapidly t
extensive delivery of the drug loaded into the baseplates. Indeed in in vitro transdermal delivery studies, approximatel
tolerance experiments raised no concerns. The blood plasma ibuprofen sodium concentrations achieved in rats (263 μg
patch design of no greater than 10 cm2 could cautiously be estimated to deliver therapeutically-relevant concentration
The objective of the work was to assess the possible interactions between the model drug diclofenac sodium (DS) and
preformulation study towards sustained release microparticles. Differential scanning calorimetry (DSC) and thermogra
spectroscopy was used to confirm the possible interactions between DS and AMC. Thermoanalytical studies confirmed
solutions were formed at DS/AMC ratios of 1:12, 1:8 and 1:6. The DS was mainly crystalline at DS/AMC ratio of 1:4, while i
interaction between the DS and the AMC. The investigations provided good facilities for the selection of a DS/AMC rati
Whereas highly porous scaffolds composed of electrospun nanofibers can mimick major features of the extracellular m
from water and aqueous solutions of hydrophilic polymers and the shell from materials with well-defined release mech
preparation and biofunctionalization of such core–shell fibers as well as applications in various areas, including neural,
Eudragit® L 100-55 nanofibers loaded with diclofenac sodium (DS) were successfully prepared using an electrospinning
was successful using a solvent mixture 5:1 (v/v) ethanol:DMAc. XRD and DSC analysis of fibers confirm electron microsc
the molecular integration of the two components. In vitro dissolution tests verified that all the drug-loaded Eudragit®
drug-loaded Eudragit® L 100-55 nanofibers have the potential to be developed as oral colon-targeted drug delivery sys
The effects of cryoprotectants on the diameter and the entrapment efficiency of ibuprofen-loaded solid lipid micropart
lipid matrix for the SLM and a soybean lecithin/bile salt used as the stabilizer. Also, trehalose, glucose, mannitol, and su
during the SLM freeze-drying process. The most suitable concentrations were proved to be 15% and 5% (wt), respective
As the number of pharmaceutical candidate compounds increases, so does the need for development workflow that is
robotic system automatically dispenses, weighs, and stores powder samples, and extracts and analyses drug substanc
at every unit operation allowed the system to be validated. In a standard procedure, drug substance and an excipient w
quantitatively discriminate between initial conditions of the incompatible powder mixtures of aspirin and magnesium s
the contact area between excipient and drug substance differs. Differential scanning calorimetry (DSC), however, did n
reported previously, demonstrating that the automated testing system is reliable. The robot reduced manual work to o
to analytical method development for drug products.
Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application
work. Satisfactory storage stability were obtained when the aspirin tablet core coated with Eudragit L30D55 film was c
properties of the coating film observed by scanning electron microscopy. Investigation of the compatibility between th
(ASA-ECT) was mostly concentrated in the internal film and the interfaces between the film and tablet core. In conclus
polymer coating layer, and increases the structure and chemical stability.
Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in cl
the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Therm
mixtures (1:1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, m
decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the character
The aim was to enhance the dissolution of lornoxicam (LOR) and to produce mini-tablets with an optimised system to
Neusilin® US2 alone or co-adsorption in the presence of different amounts of polysorbate 80. All systems were charact
and flowability. Tensile strengths, content uniformity and dissolution profiles of the mini-tablets were evaluated. The e
pharmacokinetic profile. The co-evaporate of LOR with PLU showed significantly faster dissolution and superior flowab
provided the optimum results in terms of tensile strength content uniformity and rapid drug release following a 3-mon
LOR. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2470–2483, 2014
Glycyrrhetinic acid (GA) and paeoniflorin (PF) are the main active ingredients in Chinese peony- Liquorice Decoction, a
The purpose of the present investigation is to formulate liposomes of Lornoxicam for topical delivery using Central Com
The liposomes were assessed for their particle size, charge, morphology and drug entrapment and characterized using
different dissolution media and the ex vivo release study was performed using goat skin. The cytotoxicity of Lornoxica
studies proved very less interactions between the drug and the excipients. The ex vivo studies showed flux value of 23
histopathology analysis showed absence of toxic lesions, which confirmed the suitability of the formulation for topical
Tramadol is a centrally acting analgesic drug used in veterinary and human clinical practice. Its metabolism has been lar
analytical procedure to investigate HPLC the metabolization/elimination process tramadol in urine of dogs by HPLC-FL
was extractedofwith
The purpose this different
study wasblends of solvents
to fabricate to detect the total
a triple-component or free formsystem
nanocomposite of the analytes,
consistingrespectively.
of chitosan, polyethyl
nanocomposite characteristics. The casting/solvent evaporation method was used to prepare chitosan–PEG nanocomp
thermogravimetric analysis, and Fourier transmission infrared spectroscopy were used. Drug content uniformity test, s
nanocomposite films using Franz diffusion cell. The release behavior of films was found to be sensitive to pH and ionic
rate constants obtained from kinetic modeling and flux values of ex vivo permeation studies showed that release of pi
buffer pH 1.2, water content (47.89 ± 1.53%) in HCl buffer pH 1.2, maximum cumulative drug permeation through rat skin
inflammatory
To control theeffect (0.4 cm).
minimum It can
effective be concluded
dose, and reducefromthe the results
number andthat film composition
quantity had apotent
of administered particular impact
drugs on dru
are unique
approach for localized drug delivery through the skin.
optimization of controlled released systems by using FDA approved biodegradable PLGA (poly-d,l-lactide-co-glycolide)
chronic pains. The drug releases from different ISFIs membranes with and without Tween 80 were compared over a pe
differential scanning calorimetry (DSC), and the membranes structure was studied by X-ray diffractometry (XRD) and s
significantly. The degree of crystallinity was decreased after phase inversion which helps the dissolution of drug from m
dose of the buprenorphine hydrochloride in a prolonged time. Also this surfactant can be an attractive additive for mo
Active pharmaceutical ingredients (APIs) are predominantly organic solid powders. Due to their bulk properties many A
often anticipated characteristics in pharmaceutical manufacturing. In this work, we have modified acetaminophen par
and ZnO, is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not unde
coated acetaminophen particles show cytocompatibility whereas those coated with thicker ZnO coatings exhibit the m
Drug formulations containing polyethylene glycol may give rise to formation of reaction products between the aforem
fluid chromatography has been evaluated for its possible use for determination of reactions products formed between
chromatography using silica columns and carbon dioxide modified with methanol as mobile phase. Satisfactory resolut
cetirizine or indomethacin were investigated in a reaction mixture containing polyethylene glycol 400 after incubation
identified withof
The objective mass
thisspectrometry. Cetirizine
research was to stabilizewas observednovel
a heat-labile to be prodrug
more reactive than indomethacin. The
of Δ9-tetrahydrocannabinol observed
(THC), diffe
THC-hem
detection
THC were
through theinvestigated and each
oral transmucosal detection
route. technique
For this purpose,has
theits own advantages
effects and
of processing disadvantages,
conditions but intemperatu
(processing order to b
succinate (VES), acetyltributyl citrate (ATBC), triethyl citrate (TEC), triacetin and polyethylene glycol 8000 (PEG 8000).
processed at 110 °C for 7 min were found to be favorable for hot-melt processing with a post-processing drug content o
storage was considerably reduced in the presence of the plasticizers investigated, VES being the most effective. Modu
theoretical drug remaining as opposed to only 15% remaining in PEO-only matrices when stored at 40 °C for up to 3 mon
and with increasing concentration. However, a slower release was observed with an increase in concentration of wate
Thermogravimetry/derivative thermogravimetry (TG/DTG) and differential scanning calorimetry (DSC) techniques were
(monohydrate and anhydre), polyvinylpyrrolidone K30, magnesium stearate and talc, commonly used in the pharmace
physical mixtures. For KT, the DSC curves have shown a sharp endothermic peak at 96.8 °C which corresponds to the m
powder diffraction (XRPD) were used as complementary techniques to adequately implement and assist in interpretat
stability of the KT in the binary mixtures. These possible incompatibilities were confirmed by FT-IR and X-ray analysis.
Meloxicam (MLX) is a non-steroidal anti-inflammatory cyclooxygenase (COX) inhibitor that is used to relieve inflammat
Classification System (BCS) in which dissolution is the limiting step of its bioavailability. In view of this classification, car
directly influence the quality of the product. The aim of the present work is to evaluate solid pharmaceutical formulatio
characterize and evaluate the compatibility between the drug and the excipients present in the market formulations. I
MLX was found to be incompatible with magnesium stearate after DSC analysis under binary mixtures, which was confi
Practically all medications contain excipients, which are added for the purpose of production enhancement, patient ac
Historically, excipients were termed inactive components. However, as highlighted in the present paper; excipients can
any new formulation. Further, this review also provides a description of the regulatory processes to get new excipients
scientist when selecting excipients for a new drug formulation.
A successful parenteral formulation can be developed by studying stability and compatibility of biopharmaceuticals as
growth factor (rhEGF) stability. The stability was accessed by reversed-phase high performance liquid chromatography
obtained in pH near to 7.0 in phosphate, Tris and histidine buffers as the results of the different methods revealed. The
scattering results. Nor the ionic strength neither the rhEGF concentration had significant effect on the reaction rate co
rhEGF
The oxidation
objective of and deamidation
this work were the
was to access most commoncompatibility
thymol-excipient degradation pathways. This research
using an alternative identified
protocol criticaldesign
of mixture solut
simplex centroid mixture designs with three components. Two designs were used: the design A containing stearic acid
thermal events involved with thymol (TML) – melting and evaporation –, as well as events related to excipients decom
Alternatively, nonionic surfactant P80 could be a good excipient option, as TML formulation stability was not influence
system was observed. Finally, phospholipid LC solubilizes TML extending its evaporation to higher temperatures; henc
excipients, providing
Compatibility between more
twocomplete
new activeinformation on formulation
pharmaceutical development.
ingredients In addition,
(API) and several the association
pharmaceutical of techniqu
excipients used in
(i) 3 days and subsequently analysed by FT-IR and (ii) 12 weeks of storage and analysis by HPLC. For the majority of the
general agreement between the results obtained by the two protocols. Further, the FT-IR method showed clear incom
accelerated method thus showed a clear advantage: incompatibility found after 12 weeks using HPLC was seen after 3
compounds, which might lead to changes of the intrinsic dissolution rate and potentially affect the bioavailability of th
Nanostructured lipid carriers (NLC) based topical gel of celecoxib was formulated for the treatment of inflammation an
studies. Drug encapsulation efficiency was determined using Nanosep® centrifugal device. The nanoparticulate dispers
induced rat paw edema model. The skin permeation and rat paw edema pharmacodynamic studies were carried out in
elicited prolonged activity until 24 h.
Curcumin shows effective anti-inflammatory activities but is seldom used in clinic because of its poor solubility in water
Ethosomes and traditional liposomes, were prepared as curcumin carriers respectively. Their morphology, particle size
device. Carrageenan-induced paw edema was established to evaluate the anti-inflammatory effect. From the result, th
as the same as that of particle size. The sequence of encapsulation efficiency was: PGL > Ethosomes > traditional
edema, followed by Ethosomes and Traditional liposomes. With the elevated entrapment efficiency, good transdermic
Flurbiprofen (FB)-loaded nanostructured lipid carriers (NLCs) based on Compritol®888 ATO (C888; FB-C888NLC) were
efficiency (∼90%), and long-term physical stability. Previously optimized NLCs based on stearic acid (SA; FB-SANLC) we
corneal residence time. FB-C888NLC remained in the nanometric range, whereas FB-SANLC suffered an increase in par
Both HG formulations showed plastic and low or no thixotropic properties, making them suitable for ocular application
rabbit cornea revealed enhanced transcorneal drug permeation from the systems. In vivo ocular tolerance was confirm
DESCRAGADO OK
SI
Gemifloxacin
OK
Ibuprofen, Ketoprofen
OK
aceclofenac,
OK
Ketoprofen,
OK
Meloxicam
NO OK

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Revista Mexicana de Ciencias

Revista Mexicana de Ciencias

Revista Mexicana de Ciencias

Journal of the Mexican Chemical

Revista Mexicana de Ciencias

7 7 Polímeros: Ciência e Tecnologia

9 9 Journal of the Mexican Chemical

Journal of the Mexican Chemical

11 11 Journal of the Mexican Chemical

Revista Mexicana de Ciencias

Revista de la Sociedad Química del

Revista Mexicana de Ciencias

Revista Mexicana de Ciencias

22 22 Revista Boliviana de Química

23 23 Polímeros: Ciência e Tecnologia

Journal of the Mexican Chemical

25 25 Revista Mexicana de Ciencias

Revista Mexicana de Ciencias

27 27 Revista Cubana de Química

Revista Mexicana de Ciencias

29 29 Revista Cubana de Química

30 30 Revista CENIC. Ciencias Químicas

34 34 Revista CENIC. Ciencias Químicas

Revista Mexicana de Ciencias

Revista Mexicana de Ciencias

Revista Mexicana de Ciencias

40 40 Revista CENIC. Ciencias Químicas

41 41 Journal of the Mexican Chemical

Journal of the Mexican Chemical

43 43 Revista Mexicana de Ciencias

Almidón retrogradado para uso en compresión directa. I. Caracterización y pregelatinización

Almidón retrogradado para uso en compresión directa.

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Antibacterial Activity of Pipemidic Acid ions-MgFeAl Layered Double

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