REACCIONES EN LA SINTESIS DE AMOXICILINA PREPARACION DE ANHIDRIDO MIXTO parahidroxifenil glicina sal de dane O Cloruro de pivaliol O NH CH3 O HO O K Molecular Formula

= C H KNO 13 14 5 Formula Weight = 303.35226 DISOLUCION DE 6_APA 6_APA H2N N O O S CH3 CH3 OH Trietilamina CH3 H2N A: Cloruro de metileno B: Agua desionizada CH3 O N O S CH3 CH3
-

O O NH CH3 O O O CH3 CH3

CH3

Cl CH3 H3C CH3

A: Cloruro de metileno B: N_Dimetilacetamida C: Piridina D: Acido pivalico HO

Cl

Molecular Formula = C H ClO 5 9 Formula Weight = 120.57736

Solucion de 6_APA

H3C CH3 Molecular Formula = C H NO 18 23 6 Formula Weight = 349.37832

CH3
+

+
H3C

O HN H3C

CH3

Molecular Formula = C H N 6 15 Formula Weight = 101.19 Molecular Formula = C H N O S 8 12 2 3 Formula Weight = 216.25748

Molecular Formula = C H N O S 14 27 3 3 Formula Weight = 317.44748

REACCION DE ACILACION

O O

HN

CH3 O O

CH3

H2N

S N

CH3 CH3
+

+
O CH3 CH3 O

CH3

CH Cl
2

O HN O H3C

CH3

HO H3C Molecular Formula = C H NO 18 23 6 Formula Weight = 349.37832

Molecular Formula = C H N O S 14 27 3 3 Formula Weight = 317.44748

O NH HO O HN N O Molecular Formula = C H N O S 27 40 4 7 Formula Weight = 564.6941 O S CH3 O CH3 CH3 CH3 O HN H3C
+

CH3

HO CH3 H3C CH3 Molecular Formula = C H O 5 10 2 Formula Weight = 102.1317

CH3

REACCIONES EN LA HIDROLISIS O NH HO O HN N O O S CH3 O CH3 CH3 CH3 O HN H3C AMOXICILINA TRIHIDRATO H2O NH2 HO O HN Molecular Formula = C H N O S 16 25 3 8 Formula Weight = 419.45 O O N S CH3 CH3 OH H2O H2O
+

+
CH3

HCl

H2O

CH3

Molecular Formula = C H N O S 27 40 4 7 Formula Weight = 564.6941

+
O O Molecular Formula = C H O 5 8 3 Formula Weight = 116.11522 O CH3 CH3

+
CH3 Cl HN H3C
+

Molecular Formula = C H ClN 6 16 Formula Weight = 137.65094

CH3