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JORGE FERNÁNDEZ CUEVAS

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La búsqueda de la aptitud física y la belleza

pueden consumir por completo a una persona
que por alcanzar el cuerpo ideal llegan a
extremos increíbles para lograr lo que ven como
"perfección". Es el caso de DENISE RUTKOSKI,
una ex fisicoculturista que, después de 20 años
de inyectarse con esteroides y drogas
recreativas, cambió totalmente, a causa
de los efectos de las drogas.
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Sequence of Changes in Body Composition Induced by

Testosterone and Reversal of Changes After Drug Is
Stopped
Gilbert B. Forbes, MD; Cheryl R. Porta; Barbara E. Herr, MS;
Robert C. Griggs, MD JAMA. 1992;267(3):397-399.
doi:10.1001/jama.1992.03480030075040.
Objetivo. —Estudiar los cambios en la
composición corporal debido al uso de fuertes
cantidades de testorena y la reversion de los
mismos al descontinuar el medicamento.res
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Diseño. —Se le aplicaron inyecciones semanales de enantato de

testosterone a un grupo voluntario de hombres jovenes por un
period de 1 semanas y durante ese period se les realizaron varias
evaluaciones de la masa magra por el método del Potasio 40 y
posteriormente a la suspension del medicamento en los siguientes 6
meses.
Participantes y lugar. —Hombres independientes aparentemente
sanos que se ofrecieron voluntariamente como grupo de
control en una investigación de enfeermedades
neuromusculares. Esta investigación se llevó a cabo en
el Centro de Investigaciones Clínicas.
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Cambios evaluados. —Peso corporal, Masa magra y Masa grasa (por

sustracción).
Changes in body weight, LBM, and (by subtraction) body fat.
Resultados. —La Testosterona provocó un incremento en la masa
magra y una disminución de la masa
grasa. Posteriormente los cambios progresivamente se revertieron
al suspender el uso de la testosterone.
La pérdida de masa magra coincidió con cambios en la
excreción urinaria de creatinina.
Conclusión. —La Testosterona es un poderoso agente
anabólico que además reduce la masa grasa.
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Functioning Gonadotroph Adenomas (FGA)

Context: Functioning gonadotroph adenomas (FGA)
are pituitary tumors secreting biologically active
gonadotropins. The published literature includes only
small case series or individual case reports. This review
summarizes the published data on this rare entity and,
based on them, suggests guidance on the
follow-up of these patients.
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Evidence Acquisition: A review of articles in English

retrieved from the PubMed up to December 2013 was
conducted. The following terms were used for the
search “functioning gonadotroph adenomas”, “FSH
secreting adenomas”, “LH secreting adenomas”,
“gonadotroph adenomas”, “ovarian hyperstimulation”,
“precocious puberty”.
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Evidence Synthesis: All reported cases of FGA

were assessed and information on presenting
manifestations, management approaches and
long-term outcome were reviewed.
Conclusions: FGA cause distinct manifestations
and, based on the limited published
literature, they are mostly
macroadenomas.
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Their pathogenesis remains

enigmatic. Systematic series on their
optimal management are lacking,
but the primary therapy remains
surgical excision of the
adenoma.
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Ntali G, Capatina C, Grossman A, Karavitaki

N. Functioning Gonadotroph Adenomas
(FGA). The
Journal of Clinical Endocrinology &
Metabolism.
http://press.endocrine.org/doi/pdf/
10.1210/jc.2014-2362
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hCG
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Model of hCG Signal Transduction [For those so inclined or motivated]

http://humupd.oxfordjournals.org/content/15/1/69.long
Model of hCG signal transduction showing the signaling specificity domain (SSD) on the extracellular surface of the transmembrane
domain (TMD) and the leucine-rich domain (LRD) near the SSD–TMD complex.

The hCG/LH receptor is encoded by a single gene, located on human chromosome 2p21 and belongs to superfamily of G protein-
coupled seven transmembrane (TM) domain receptors.

The NH2- and COOH-terminal portions of the LRD contact the ends of the SSD and TMD helices. hCG binding increases the
distance between the top of the SSD and the top of LRD, promotes the rotation of LRD and a gate-like movement of the LRD and
creates a binding pocket for TMD rearrangement and signaling.

After binding, hCG activates its receptor and the heterotrimeric G-protein-coupled receptor is formed. GDP is
released from the G-protein and is replaced by GTP.

This leads to dissociation of the G-protein subunits into α-subunit and βγ dimer. Gα activates adenylate
cyclase, which leads to an increase in intracellular cAMP levels, stimulation of PKA expression of
steroidogenic acute regulatory protein (StAR), cholesterol uptake, and steroidogenic enzymes activation
(P450scc, 3β-HSD, P450c17).
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3-(4-aminophenyl)-3-ethyl-2,6-
piperidinedione
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6-methyldiene androsta-1,4-diene-3,17-
dione
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1,3-Benzenediacetonitrile, alpha,alpha,alpha',alpha'-
tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
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ACNÉ
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ACNÉ
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Hirsutismo
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Labia minora
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Hipertrofia del clítoris en

recién nacida
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Some bodybuilders, particularly at professional level, inject

substances such as "site enhancement oil", commonly known as
synthol, to mimic the appearance of developed muscle where it
may otherwise be disproportionate or lagging. This is known as
"fluffing".[34][35] Synthol is 85% oil, 7.5% lidocaine, and 7.5%
alcohol.[34] It is not restricted, as it is ostensibly sold for topical
use only, and many brands are available on the internet.[36] The
use of injected oil to enhance muscle appearance in
the late 19th century was abandoned[citation needed]
due to health risks such as sclerosing lipogranuloma.
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Its use was revived more recently by

bodybuilders.[37][38] Use can cause pulmonary
embolisms, nerve damage, infections, stroke,[34] and
the formation of oil-filled granulomas, cysts or ulcers
in the muscle.[38][39][40] Sesame oil is often used, which
can cause allergic reactions such as vasculitis.[41] An
aesthetic issue is drooping of muscle under
gravity.[36]
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Bibliografía:

1. World anabolic review, Grundig y Bachman, Muscle books

2. Biochemestry of exercise and training, Maughman, Gleeson
and Greenhaf, Oxford University press
3. Steroids Altered states, James Wright, Cooper Publishing
group
4. Guía de referencia anabólica, Nathaniel Phillips, Mile High
Publishing
5. Anabolic steroids side effects, Mauro di Pasquale, MGD press
6. Anabolic steroids in sports and exercise, Charles Yesalis,
Human Kinetics
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7. Endocrinología Clínica. Felipe F. Casanueva, Sonia

Gaztambide Sáenz
8. Anabolics 2009. Llewellyn William. Molecular
Nutrition
9. Chemical Muscle Enhancement. Rea L. Bodybuilders
Desk Reference 2002.
10. The Anabolic Solution. Di Pasquale Mario G. 2002
11. The Layman’s Guide to Steroids. Hart Mick
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17ß-hydroxyandrost-4-en-3-one
(Testosterona)
17-hydroxy-10,13-dimethyl- 1, 2, 6, 7, 8, 9, 11, 12, 14, 15, 16, 17-
dodecahydrocyclopenta[a] phenanthren-3-one
 Jorge Fernández
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