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Recibido 2 de octubre de 2006, aprobado 10 de mayo de 2007.

Homero Fernando Pastrana

Alba vila

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Maestra en Ingeniera Elctrica. Doctorado en Fsica de

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Semiconductores. Profesora Asistente. Departamento

hmmfast@hotmail.com

de Ingeniera Elctrica y Electrnica, Facultad de IngeQLHUtD 8QLYHUVLGDG GH ORV $QGHV %RJRWi '& &RORPbia.
a-avila@uniandes.edu.co

RESUMEN Bien se ha dicho que nunca hay enemigos pe-

nomedicina [2], [3]. En el presente artculo revisaremos

queos, dicha frase no podra ser mas cierta cuando

desarrollos nanotecnolgicos aplicados en enfermeda-

se trata de la batalla que es librada entre el cuerpo y

des de alta mortalidad y cuyo tratamiento actual, que

diferentes agentes patgenos, mutaciones celulares

es descrito, slo logra soluciones parciales o de man-

y sustancias nocivas. En la actualidad nuestro conoci-

tenimiento, como es el caso del cncer o la diabetes,

miento ha permitido manipular a escalas nanomtricas

sin tener solucin a la enfermedad de base. Entonces el

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impacto que la nanomedicina puede tener en el futuro

desarrollo de este conocimiento que permite avances

es promisorio y mejorara las condiciones de salud de la

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PHQRUUHTXHULPLHQWRGHPDWHULDSULPDPD\RUHFLHQ-

humanidad.
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cia en el desempeo de dispositivos, entre otras [1], [2].

Nanomedicina, enfermedades, nanmetro, patgenos,

El uso de nantecnologa en medicina se conoce como na-

mortalidad.

1DQRPHGLFH6WDWHRI WKH$UW
ABSTRACT $OZD\VKDYHEHHQWROGWKDWWKHUHLVQRWWLQ\

nanomedicine [2], [3]. This paper review nanotechnologic

enemies, this statement couldnt be more true when

develops apply to diseases with high mortality and

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treatments that doesnt solve the problem deeply they

different pathogen agents, cellular mutations, and

just handle the disease with partial solutions. Therefore,

dangerous substances. Right now our knowledge allow

nanomedicine will have greater impact in the future,

XV WR KDQGOH WKH PDWWHU DW QDQRVFDOH 

improving the health issues of humanity.

m) sizes. The nanotechnology develop this knowledge

.(<:25'6

and be able to improve things as new materials, small

Nanomedicine, Diseases, Nanometer, Pathogens,

amount of material to build devices, better performance

Mortality.

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Using nanotechnology to solve health problems is call

#25 revista de ingeniera. Universidad de los Andes. rev.ing. ISSN. 0121-4993. Mayo de 2007

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REFERENCIAS

[12] D. Kasper. E. Braunwald. A. Fauci.

Harrisons Principles on Internal Medicine.0F*UDZ+LOO(G

[1]
1]] Science policy council.

)LIWHHQWK

86HQYLURQPHQWDOSURWHFWLRQDJHQF\Nanotechnolog y White
Paper, 

[13] A. Papadakis. M. Tierney. J. McPhee.

Current Medical Diagnosis And Treatment 0F*UDZ+LOO

[2]
2]] European Commission.

WKHG

Nanotechnolog y for health. Strategic research agenda.

/X[HPEXUJR1RY

[14] KWWSZZZVOLGHVKDUHQHWOTFBPLJXHO6OLGH6KDUHFRP
5HYLVDGRHQPD\R

[3]
3]] R. A. Freitas.
:KDW,V1DQRPHGLFLQH"1DQRPHGLFLQHNanotechnolog y,
Biolog y, and MedicineSS

[15]
15]] American Heart association.
Guidelines for early management of adults with ischemic stroke,


[4]
4]] G. E. Gonzlez.
Nanotechnologia.%XLQDPLD

[16] R. Lee, M. Davis.

Nanofibers Improves Cell Therapy For Myocardial Infarction Local

[5]
5]] P. Holister.
1DQRWHFK7KH7LQ\5HYROXWLRQCMP Cientifica

[6]
6]] R. Freitas Jr.

Myocardial Insulin-Like Growth Factor 1 (IGF-1) Delivery With

Biotinylated Peptide.31$6

[17] Y. Hwa, Y. Hsu.

&XUUHQW6WDWXV2I1DQRPHGLFLQD$QG0HGLFDO

,QWUD$UWHULDO$SSOLFDWLRQ2I0DJQHWLF1DQRSDUWLFOHV

1DQRURERWLFV&RPSXWDWLRQDODQG7KHRUHWLFDO

)RU7DUJHWHG7KURPERO\WLF7KHUDS\$5DW(PEROLF

1DQRVFLHQFH

0RGHOJournal of Magnetism and Magnetic Materials

[7]
7]] National Nanotechnology Initiative.

[18] T. Yambe. Y. Shiraishi.

Research and Developing Founding in the Presidents 2006 Budget

$UWLFLDO0\RFDUGLXP:LWK$Q$UWLFLDO%DURUHH[6\VWHP

2IILFHRIVFLHQFHDQGWHFKQRORJ\SROLF\

8VLQJ1DQR7HFKQRORJ\Biomedicine & Pharmacotherapy 

SSVV

[8]
8]] National Institute of Health.
Summary of the FY 2006 presidents Budget.)HE

[19]
19]] Standford comprehensive cancer center.
KWWSFDQFHUVWDQIRUGHGXLQIRUPDWLRQFDQFHU'LDJQRVLV

[9]
9]] A. Avila, H. Pastrana.

5HYLVDGR-XQLR

,PSDFW2I1DQRPHGLFLQH,Q3DWKRORJLHV:LWK*UHDW
,QFLGHQFH,Q&RORPELD$V'HYHORSLQJ&RXQWU\WK
&RQJUHVVRI1DQRWHFKQRORJ\6DQ)UDQFLVFR

[20]
20]] Doxil Product information.
Tibotec Therapeutics.1HZ-HUVH\86$

,$1$12

[21] A. Bao, W. Phillips.

[10]
10]] American heart association.
Heart Disease And Stroke Statistics,

Potencial Use Of Drug Carried-Liposomes For Cancer Therapy

Via Direct Intratumoral Injection International Journal Of
Pharmaceutics, 

[11]
11]] W. Ganong.
Fisiologia Medica.0DQXDOPRGHUQRD(G

[22] D. Kumar. Y Zhang.

[32]
32]] A. Nissenson, M. Edelstein.

Multi-funtional nanoparticles for cancer therapy. $GYDQFHG

7KHKXPDQQHSKURQILOWHUWRZDUGDFRQWLQXRXVO\

0DWHULDOV

IXQFWLRQLQJLPSODQWDEOH$UWLILFLDOQHSKURQV\VWHP
%ORRG3XULILFDWLRQS

[23]
23]] M. J. Vicent and Ruth Duncan.
3RO\PHUFRQMXJDWHVQDQRVL]HGPHGLFLQHVIRUWUHDWLQJ
FDQFHUTR ENDS in Biotechnolog y9RO1R-DQXDU\

[33]
33]] World Health Organization.
Department of measurement and sadistic. 'HFHPEHU



[34]
34]] C. Daz.
[24]
24]] Federacin diabetolgica colombiana.
KWWSZZZIGFRUJFR5HYLVDGRDJRVWRGH

[25]
25]] National diabetes statistics.

Gua para el manejo del VIH/SIDA basado en la evidencia

Colombia0LQLVWHULRGHSURWHFFLyQVRFLDO

[35]
35]] Nanoviricide Inc.

KWWSGLDEHWHVQLGGNQLKJRYGPSXEVVWDWLVWLFV

KWWSZZZQDQRYLULFLGHVFRPSURGXFWVKWPO5HYLVDGR

5HYLVDGRHQHURGH

'LFLHPEUHGH

[26]
26]] Bayer health care.
KWWSZZZED\HUFDUHGLDEHWHVFRPKWP5HYLVDGR

[36]
36]] Starpharma Holdings LTD.
ZZZVWDUSKDUPDFRPUHFXSHUDGRQRYLHPEUH

0D\R

[37]
37]] www.carraguard.com
[27] J. Quincy Brown, M.J. McShane.

5HYLVDGRPDU]RGH

0RGHOLQJRIVSKHULFDOIOXRUHVFHQWJOXFRVHPLFURVHQVRU
V\VWHPV'HVLJQRIHQ]\PDWLFVPDUWWDWWRRVBiosensors and
BioelectronicsSS

[38] Z. Cheng.
$FXWHWR[LFRORJLFDOHIIHFWVRIFRSSHUQDQRSDUWLFXOHVLQ
YLYR7R[LFRORJ\OHWWHU

[28] L. Piemonti, B. E. Leone.

+XPDQ3DQFUHDWLF,VOHWV3URGXFHDQG6HFUHWH0&3
&&/5HOHYDQFHLQ+XPDQ,VOHW7UDQVSODQWDWLRQ
Diabetes, -DQXDU\

[29] T. Desai.
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LPPXQRLVRODWLRQDQGELRPROHFXODUVHSDUDWLRQ
%LRPROHFXODUHQJLQHHULQJ

[30]
30]] Nanospectra Inc.
KWWSZZZQDQRVSHFWUDFRP1DQR6FDOH2SWLFV
KWP5HYLVDGRRFWXEUH

[31]
31]] University of Virginia Health System.
KWWSZZZKHDOWKV\VWHPYLUJLQLDHGXXYDKHDOWKSHGVB
XURORJ\UI KXEFIP5HYLRVDGRMXQLR

[39] K. Eric Drexler.

Engines of Creation$QFKRU%RRNV

# 25 revista de ingeniera

tcnica

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