cidos Aminados

R NH2 C H COOH

cidos aminados so blocos para a formao de protenas Eles possuem os grupos amino e cido Existem 20 diferentes AA a mesma estrutura, variando o grupo R O carbono alfa quiral So anfteros Em pH fisiolgico, a maioria dos AA esto em sua forma zwitterinica.

R NH3+ C H COO-

Hidrofbicos
Glicina (G) Alanina (A)

Valina (V)

Isoleucina (I)

Hidrofbicos
Prolina (P) Metionina (M)

Hidrofbicos
Leucina (L)

Fenilalanina (F)

Triptofano (W)

Hidroflicos
Asparagina (N)

Hidroflicos
Glutamina (Q) Serina (S)

Cistena (C) Treonina (T) Tirosina (Y)

cidos
Lisina (K)

Bsicos
Arginina (R)

cido asprtico (D)

cido glutmico (E)

Histidina (H)

Amino acid sequence NLKTEWPELVGKSVEEA KKVILQDKPEAQIIVLPV GTIVTMEYRIDRVRLFVD KLDNIAEVPRVG

Folding!

-helix

-sheet

Tertiary structure

Quaternary structure

Primria (seqncia de AA) Secundria -hlice, -pregueada Terciria Estrutura 3D formada com ajuda das estruturas secundrias) Quaternria + de uma cadeia polipeptdica

DNA molecule
DNA sequence
transcription
atgcaaactctttctgaacgcctcaagaagaggcgaattgcgttaaaaatgacgc aaaccgaactggcaaccaaagccggtgttaaacagcaatcaattcaactgattg aagctggagtaaccaagcgaccgcgcttcttgtttgagattgctatggcgcttaact gtgatccggtttggttacagtacggaactaaacgcggtaaagccgcttaa augcaaacucuuucugaacgccucaagaagaggcgaauugcguuaaaaauga cgcaaaccgaacuggcaaccaaagccgguguuaaacagcaaucaauucaacug auugaagcuggaguaaccaagcgaccgcgcuucuuguuugagauugcuaugg cgcuuaacugugauccgguuugguuacaguacggaacuaaacgcgguaaagc cgcuuaa MQTLSERLKKRRIALKMTQTELATKAGVKQQSIQLIEAGVT KRPRFLFEIAMALNCDPVWLQYGTKRGKAA

RNA sequence
translation

protein sequence

protein structure protein function

G C G C T T A A G C G C

DNA base C G sequence C G A A T T C G C G

T TTT TTC TTA TTG CTT CTC CTA CTG ATT ATC ATA ATG GTT GTC GTA GTG

Phe Leu

Leu

Ile Met Val

C TCT TCC TCA TCG CCT CCC CCA CCG ACT ACC ACA ACG GCT GCC GCA GCG

Second letter A TAT TAC Ser TAA TAG CAT CAC Pro CAA CAG AAT AAC Thr AAA AAG GAT GAC Ala GAA GAG

Tyr Stop His Gln Asn Lys Asp Glu

G TGT TGC TGA TGG CGT CGC CGA CGG AGT AGC AGA AGG GGT GGC GGA GGG

Cys Stop Trp Arg

Ser Arg

Gly

T C A G T C A G T C A G T C A G

DNA Gene

Genome
Gene Gene Gene Gene Gene Gene Gene Gene Gene Gene Gene Gene Gene Gene Protein Protein Protein Protein Protein Protein Protein Protein Protein Protein Protein Protein Protein Protein

Third letter

First letter

Protein

10

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