Notas Del Código de La Obesidad

NOTAS
INTRODUCCIÓN:
NOTAS 1- CBC News [Internet]. 3 de marzo de 2014. «Canada’s obesity rates triple in less than 30
years». Puede leerse en https://www.cbc.ca/news/health/canada-s-obesity-rates-triple-inless-
than-30-years-1.2558365 Fecha de la consulta: 27 de julio de 2015.
NOTAS 1- Begley, S. «America’s hatred of fat hurts obesity fight». Reuters [Internet]. 11
de mayo de 2012. Puede leerse en www.reuters.com/article/us- obe-sity-stig-insi-ght-ricas-
ricas-tred-fat-hurts-obesity-
fight- idUSBRE84A0PA20120511.PA20120511. Fecha de la consulta: 13 de abril de 2015.
2- Centers for Disease Control and Prevention [Internet]. «Healthy weight: it’s a diet, not a
lifestyle!» (actualizado el 24 de enero de 2014). Puede leerse
en https://www.cdc.gov/media/subtopic/matte/pdf/031210-Healthy-Weight.pdf. Fecha de la
consulta: 8 de abril de
2015. 3- National Heart, Lung, and Blood Institute [Internet]. «Maintaining a healthy we- i
ght on the go». Abril de 2010. Puede leerse
en www.nhlbi.nih.gov/health/public/heart/obesity/aim_hwt.pdf. Fecha de la consulta: 8 de
abril de 2015. 4- Brillat-
Savarin, J. A. The physiology of taste. Penguin Books, 1970, pp. 208-
209. (En castellano: Fisiología del gusto. España: Books4Pocket, 2014). 5- Banting, Willia
m. Letter on Corpulence, Addressed to the Public. Puede leerse en www.thefitblog.net/ebo
oks/LetterOnCorpulence/LetteronCorpulence.pdf. Fecha de la consulta: 12 de abril de
2015. 6- Fuente de los datos de la figura 1.1: Jones, D. S., Podolsky, S. H. y Greene, J. A. «
The burden of disease and the changing task of medicine». The New England Jour- nal of
Medicine, 2 de junio de 2012; 366 (25): 2333-
2338. 7- Arias, E. Centers for Disease Control and Prevention [Internet]. «National Vital St
atistics Reports. United States life tables 2009». 6 de enero de 2014. Puede
leerse en www.cdc.gov/nchs/data/nvsr/nvsr62/nvsr62_07.pdf. Fecha de la consulta: 12 de
abril de 2015.
8- «Heart attack». The New York Times [Internet] (revisado el 30 de junio de 2014). Puede
leerse en www.nytimes.com/health/guides/disease/heart-attack/risk-
factors.html. Fecha de la consulta: 8 de abril de
2015. 9- Yudkin, J. «Diet and coronary thrombosis hypothesis and fact». The Lancet. 27 de
julio de 1957; 273 (6987): 155-
162. 10- Yudkin, J. «The causes and cure of obesity». The Lancet. 19 de diciembre de 1959
; 274 (7112): 1135-
1138. 11- USDA Factbook. Capítulo 2: «Profiling food consumption in America». Puede le
erse en https://assets.documentcloud.org/documents/2461300/usda-chapter2.pdf. Fecha de
la consulta: 26 de abril de
2015. 12- Fuente de los datos de la figura 1.2: Centers for Disease Control [Internet], NCH
S Health E-Stat. «Prevalence of overweight, obesity, and extreme obesity among adults:
United States, trends 1960-1962 through 2007-2008». Actualizado el 6 de junio de 2011.
Puede leerse
en www.cdc.gov/nchs/data/hestat/obesity_adult_07_08/obesity_adult_07_08.htm. Fecha de
la consulta: 26 de abril de 2015.
NOTAS 1- Bouchard, C. «Obesity in adulthood: the importance of childhood and parental obesity»
. The New England Journal of Medicine. 25 de septiembre de 1997; 337 (13): 926-
927. 2- Guo, S. S., Roche, A. F., Chumlea, W. C., Gardner, J. D. y Siervogel, R. M. «The predictive
value of childhood body mass index values for overweight at age 35
y». The American Journal of Clinical Nutrition. Abril de 1994; 59 (4): 810-
819. 3- Stunkard, A. J. et al. «An adoption study of human obesity». The New England Journal of
Medicine. 23 de enero de 1986; 314 (4): 193-198. 4- Stunkard, A. J. et al. «The body-
mass index of twins who have been reared apart». The New England Journal of Medicine. 24 de ma
yo de 1990; 322 (21): 1483- 1487.
NOTAS 1- Wright, J. D., Kennedy-

Stephenson, J., Wang, C. Y., McDowell, M. A. y Johnson, C. L. «Trends in intake of
energy and macronutrients: United States, 1971-2000». The Morbidity and Mortality
Weekly Report, Centers for Disease Control
and Prevention. 6 de febrero de 2004; 53 (4): 80-
82. 2- Ladabaum, U. et al. «Obesity, abdominal obesity, physical activity, and caloric intak
e in US adults: 1988 to 2010». The American Journal of Medicine. Agosto de 2014; 127
(8): 717-727. 3- Griffith, R., Lluberas, R. y Luhrmann, M. «Gluttony in England? Long-
term change in diet». The Institute for Fiscal Studies. 2013. Puede leerse en www.ifs.org.
uk/bns/bn142.pdf. Fecha de la consulta: 26 de abril de 2015". Fecha de la consulta: 26 de
abril de
2015. 4- Kolata, G. «In dieting, magic isn’t a substitute for science». The New York Times [
Internet]. 9 de julio de 2012. Puede leerse
en www.nytimes.com/2012/07/10/health/nutrition/q-and-a-are-high-protein-low-carb-diets-
effective.html?_r=0. Fecha de la consulta: 8 de abril de
2015. 5- Benedict, F. «Human vitality and efficiency under prolonged restricted diet». Carn
egie Institute of Washington; 1919. Puede leerse
en https://archive.org/details/humanvitalityeff00beneuoft. Fecha de la consulta: 26 de abril
de
2015. 6- Keys, A., Brožek, J., Henschel, A., Mickelsen, O. y Taylor, H. L. The Biology of
Human Starvation (2 volúmenes). MINNE ed. St. Paul (Minnesota, EUA): Univer- sity of
Minnesota Press,
1950. 7- Guetzkow, H. G. y Bowman, P. H. Men and hunger: a psychological manual for r
e- lief workers 1946. Elgin (Illinois, EUA): Brethren Publishing House, 1946.
8- Kalm, L. M. y Semba, R. D. «They starved so that others be better fed: remem- bering A
ncel Keys and the Minnesota Experiment». The Journal of Nutrition. 1 de junio de 2005;
135 (6): 1347-
1352. 9- Ancestry Weight Loss Registry [Internet]. Blog. «They starved, we forgot». 4 de n
oviembre de 2012. Puede leerse en www.awlr.org/blog/they-starved-we-forgot. Fecha de la
2015. 10- Pieri, J. «Men starve in Minnesota». Life. 30 de julio de 1945; 19 (5): 43-
46. 11- Rosenbaum et al. «Long-
term persistence of adaptive thermogenesis in subjects who have maintained a reduced bo
dy weight». The American Journal of Clinical Nutrition. Octubre de 2008; 88 (4): 906-
912. 12- Howard, B. V. et al. «Low fat dietary pattern and weight change over 7 years: the
Women’s Health Initiative Dietary Modification Trial». The Journal of the American Medic
al Association. 4 de enero de 2006; 295 (1): 39-
49. 13- Kennedy, E. T., Bowman, S. A., Spence, J. T., Freedman, M. y King, J. «Popular di
ets: correlation to health, nutrition, and obesity». Journal of the American Dietetic Associati
on. Abril de 2001; 101 (4): 411-420. 14- Suminthran, P. «Long-
term persistence of hormonal adaptations to weight loss». The New England Journal of Me
dicine. 27 de octubre de 2011; 365 (17): 1597- 1604. 15- Rosenbaum, M. S. M., Pavlovich,
K., Leibel, R. y Hirsch, J. «Leptin reverses weight loss-induced changes in regional neural
activity responses to visual food
sti- muli». The Journal of Clinical Investigation. 1 de julio de 2008; 118 (7): 2583-
2591. 16- O’Meara, S., Riemsma, R., Shirran, L., Mather, L. y Ter Riet, G. «A systematic r
e- view of the clinical effectiveness of orlistat used for the management of
obesity». Obesity Reviews. Febrero de 2004; 5 (1): 51-68.
17- Torgerson et al. «Xenical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study».
Diabetes Care. Enero de 2004; 27 (1): 155-
161. 18- Peale, C. «Canadian ban adds to woes for P&G’s olestra». Cincinnati Enquirer [Internet].
23 de junio de 2000. Puede leerse
en http://enquirer.com/editions/2000/06/23/fin_canadian_ban_adds_to.html. Fecha de la consulta: 6
de abril de
2015. 19- Gentilvisio, Chris. «The 50 Worst Inventions». Time Magazine [Internet]. Puede leerse
en http://content.time.com/time/specials/packages/article/0,28804,1991915_1991909_1991785,00.h
tml. Fecha de la consulta: 15 de abril de 2015.
NOTAS 1- British Heart Foundation. «Physical activity statistics 2012». Health Promotion
Research Group Department of Public Health, University of Oxford. Julio de 2012. Puede
leerse en www.bhf.org.uk/~/media/files/research/heart-statistics/m130-bhf_physical-
activity-supplement_2012.pdf. Fecha de la consulta: 8 de abril de
2015. 2- Public Health England [Internet]. Fuente de los datos: Organisation for Eco- nomi
c Co-operation and Development. «Trends in obesity prevalence». Puede
leerse en www.oecd.org/health/obesity-
update.htm. Fecha de la consulta: 8 de abril de 2015. 3- «Countries that exercise the most in
clude United States, Spain, and France». The Huffington Post [Internet]. 31 de diciembre de
2013. Puede leerse en http://www.huffingtonpost.ca/2013/12/31/country-exercise-most-
_n_4523537.html. Fecha de la consulta: 6 de abril de 2015. 4- Dwyer-
Lindgren, L., Freedman, G., Engell, R. E., Fleming, T. D., Lim, S. S. y Mu- rray, C. J.
Mokdad, A. H. «Prevalence of physical activity and obesity in US counties, 2001-
2011: a road map for action». Population Health Metrics. 10 de julio de 2013; 11: 7. Puede
leerse en www.biomedcentral.com/content/pdf/1478-7954-11-
7.pdf. Fecha de la consulta: 8 de abril de
2015. 5- Byun, W., Liu, J. y Pate, R. R. «Association between objectively measured seden-
tary behavior and body mass index in preschool children». International Journal of Obesity
(Londres). Julio de 2013; 37 (7): 961-965. 6- Pontzer, H. «Debunking the hunter-
gatherer workout». The New York Times [Internet]. 24 de agosto de 2012. Puede leerse en
www.nytimes.com/2012/08/26/opinion/sunday/debunking-the-hunter-gatherer-
workout.html?_r=0. Fecha de la consulta: 8 de abril de
2015. 7- Westerterp, K. R. y Speakman, J. R. «Physical activity energy expenditure has not
declined since the 1980s and matches energy expenditure of wild mammals». In- ternationa
l Journal of Obesity (Londres). Agosto de 2008; 32 (8): 1256-
1263. 8- Ross, R. y Janssen, I. «Physical activity, total and regional obesity: dose-
response considerations». Medicine & Science in Sports & Exercise. Junio de 2001; 33 (6 s
upl.): S521-
S527. 9- Church, T. S., Martin, C. K., Thompson, A. M., Earnest, C. P. y Mikus, C. R. et al
. «Changes in weight, waist circumference and compensatory responses with different
doses of exercise among sedentary, overweight postmenopausal
women». PLoS ONE. 2009; 4 (2): e4515. DOI: 10.1371/journal.pone.0004515. Fecha de la
2015. 10- Donnelly, J. E., Honas, J. J., Smith, B. K., Mayo, M. S., Gibson, C. A., Sullivan,
D. K., Lee, J., Herrmann, S. D., Lambourne, K. y Washburn, R. A. «Aerobic
exercise alone results in clinically significant weight loss: Midwest Exercise trial 2». Obesit
y (Silver Spring). PubMed. Marzo de 2013; 21 (3): E219-28. DOI:
10.1002/oby.20145. Fecha de la consulta: 6 de abril de
2015. 11- Church, T. S. et al. «Changes in weight, waist circumference and compensatory r
esponses with different doses of exercise among sedentary, overweight
postmenopausal women». PLoS ONE. 2009; 4 (2): e4515. DOI: 10.1371/ journal.pone.00
04515. Fecha de la consulta: 6 de abril de
2015. 12- McTiernan, A. et al. «Exercise effect on weight and body fat in men and women»
. Obesity. Junio de 2007; 15 (6): 1496-
1512. 13- Janssen, G. M., Graef, C. J. y Saris, W. H. «Food intake and body composition
in novice athletes during a training period to run a marathon». International Journal of Sports Medi
cine. Mayo de 1989; 10 (1 supl.): S17-
S21. 14- Buring et al. «Physical activity and weight gain prevention, Women’s Health Study». The
Journal of the American Medical Association. 24 de marzo de 2010; 303 (12): 1173-
1179. 15- Sonneville, K. R. y Gortmaker, S. L. «Total energy intake, adolescent discre- tionary beh
aviors and the energy gap». International Journal of Obesity (Londres). Diciembre de 2008; 32
supl. 6: S19-
S27. 16- «Child obesity will NOT be solved by PE classes in schools, say researchers». Daily Mail
UK [Internet]. 7 de mayo de 2009; Health. Puede leerse en www.dailymail.co.uk/health/article-
1178232/Child-obesity-NOT-solved-PE-classes-schools-sayresearchers.html. Fecha de la consulta:
8 de abril de
2015. 17- Williams, P. T. y Thompson, P. D. «Increased cardiovascular disease mortality associated
with excessive exercise in heart attack survivors». Mayo Clinic Procee- dings [Internet]. Agosto de
2014. Puede leerse en www.mayoclinicproceedings.org/article/S0025-6196(14)00437-
6/fulltext. Fecha de la consulta: 8 de abril de 2015.
NOTAS 1-
Sims, E. A. «Experimental obesity in man». The Journal of Clinical Investigation. Mayo de
1971; 50 (5): 1005-
1011. 2- Sims, E. A. et al. «Endocrine and metabolic effects of experimental obesity in man
». Recent Progress in Hormone Research. 1973; 29: 457-
496. 3- Ruppel Shell, E. The hungry gene: the inside story of the obesity industry. Nueva Y
ork (EUA): Grove Press,
2003. 4- Kolata, G. Rethinking thin: the new science of weight loss —
and the myths and reali- ties of dieting. Nueva York (EUA): Farrar, Straus and Giroux, 200
8. 5- Levine, J. A., Eberhardt, N. L. y Jensen, M. D. «Role of nonexercise activity ther- mo
genesis in resistance to fat gain in humans». Science. 8 de enero de 1999; 283 (5399): 212-
214. 6- Diaz, E. O. «Metabolic response to experimental overfeeding in lean and ove- rweig
ht healthy volunteers». The American Journal of Clinical Nutrition. Octubre de 1992; 56
(4): 641-
655. 7- Kechagias, S., Ernersson, A., Dahlqvist, O., Lundberg, P., Lindstrom, T. y Nys- tro
m, F. H. «Fastfood-based hyper-alimentation can induce rapid and
profound elevation of serum alanine aminotransferase in healthy subjects». Gut. Mayo de 2
008; 57 (5): 649-
654. 8- DeLany, J. P., Kelley, D. E., Hames, K. C., Jakicic, J. M. y Goodpaster, B. H. «Hig
h energy expenditure masks low physical activity in obesity». International Journal of Obe
sity (Londres). Julio de 2013; 37 (7): 1006-
1011. 9- Keesey, R. y Corbett, S. «Metabolic defense of the body weight set-
point». Re- search publications - Association for Research in Nervous and Mental Disease.
1984; 62: 87-96.
10- Leibel, R. L. et al. «Changes in energy expenditure resulting from altered body weight»
. The New England Journal of Medicine. 9 de marzo de 1995; 332 (10); 621- 628. 11- Lusti
g, R. «Hypothalamic obesity: causes, consequences, treatment». Pediatric Endocrinology R
eviews. Diciembre de 2008; 6 (2): 220-
227. 12- Hervey, G. R. «The effects of lesions in the hypothalamus in parabiotic rat». The J
ournal of Physiology. 3 de marzo de 1959; 145 (2): 336-
52.3. 13- Heymsfield, S. B. et al. «Leptin for weight loss in obese and lean adults: a rando
mized, controlled, dose-
escalation trial». The Journal of the American Medical Association. 27 de octubre de 1999;
282 (16): 1568-1575.
NOTAS 1- Tentolouris, N., Pavlatos, S., Kokkinos, A., Perrea, D., Pagoni, S. y Katsilambros, N.
«Dietinduced thermogenesis and substrate oxidation are not different between lean and obese
women after two different isocaloric meals, one rich in protein
and one rich in fat». Metabolism. Marzo de 2008; 57 (3): 313-
320. 2- Fuente de los datos de la figura 6.1: Ibid.
NOTAS 1- Polonski, K., Given, B. y Van Cauter, E. «Twenty-
four hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects».
The Journal of Clinical Investigation. Febrero de 1988; 81 (2): 442-
448. 2- Ferrannini, E., Natali, A. y Bell, P. et al. «Insulin resistance and hypersecretion in o
besity». The Journal of Clinical Investigation. 1 de septiembre de 1997; 100 (5): 1166-
1173. 3- Han, T. S., Williams, K., Sattar, N., Hunt, K. J., Lean, M. E. y Haffner, S. M. «An
alysis of obesity and hyperinsulinemia in the development of metabolic
syndrome: San Antonio Heart Study». Obesity Research. Septiembre de 2002; 10 (9): 923
-931. 4- Russell-Jones, D. y Khan, R. «Insulin-
associated weight gain in diabetes: causes, effects and coping strategies». Diabetes, Obesity
and Metabolism. Noviembre de 2007; 9 (6): 799-
812. 5- White, N. H. et al. «Influence of intensive diabetes treatment on body weight and c
omposition of adults with type 1 diabetes in the Diabetes Control and
Compli- cations Trial». Diabetes Care. 2001; 24 (10): 1711-1721. 6- «Intensive blood-
glucose control with sulphonylureas or insulin compared with conventional treatment and
risk of complications in patients with type 2
diabetes (UKPDS33)». The Lancet. 12 de septiembre de 1998; 352 (9131): 837-
853. 7- Holman, R. R. et al. «Addition of biphasic, prandial, or basal insulin to oral the- rap
y in type 2 diabetes». The New England Journal of Medicine. 25 de octubre de 2007; 357
(17): 1716-
1730. 8- Henry, R. R., Gumbiner, B., Ditzler, T., Wallace, P., Lyon, R. y Glauber, H. S. «In
tensive conventional insulin therapy for type II diabetes». Diabetes Care. Enero
de 1993; 16 (1): 23-
31. 9- Doherty, G. M., Doppman, J. L., Shawker, T. H., Miller, D. L., Eastman, R. C., Gord
en, P. y Norton, J. A. «Results of a prospective strategy to diagnose,
localize, and resect insulinomas». Surgery. Diciembre de 1991; 110 (6): 989-
996. 10- Ravnik-
Oblak, M., Janez, A. y Kocijanicic, A. «Insulinoma induced hypoglycemia in a type 2 dia
betic patient». Wien KlinWochenschr. 30 de abril de 2001; 113 (9): 339-
341. 11- Sapountzi, P. et al. «Case study: diagnosis of insulinoma using continuous glu- co
se monitoring system in a patient with diabetes». Clinical Diabetes. Julio de 2005; 23 (3):
140-
143. 12- Smith, C. J., Fisher, M. y McKay, G. A. «Drugs for diabetes: part 2 sulphon- ylure
as». The British Journal of Cardiology. Noviembre de 2010; 17 (6): 279-
282. 13- Viollet, B., Guigas, B., Sanz García, N., Leclerc, J., Foretz, M. y Andreelli, F. «Ce
llular and molecular mechanisms of metformin: an overview». Clinical Science (Londres).
Marzo de 2012; 122 (6): 253-
270. 14- Klip, A. y Leiter, L. A. «Cellular mechanism of action of metformin». Diabetes C
are. Junio de 1990; 13 (6): 696-
704. 15- King, P., Peacock, I. y Donnelly, R. «The UK Prospective Diabetes Study (UKPD
S): clinical and therapeutic implications for type 2 diabetes». British Journal of Clinical Ph
armacology. Noviembre de 1999; 48 (5): 643-
648. 16- UK Prospective Diabetes Study (UKPDS) Group. «Effect of intensive blood- gluc
ose control with metformin on complications in overweight patients with
type 2 diabetes (UKPDS34)». The Lancet. 12 de septiembre de 1998; 352 (9131): 854-
865. 17- DeFronzo, R. A, Ratner, R. E., Han, J., Kim, D. D., Fineman, M. S. y Baron, A. D.
«Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in
metformin-treated patients with type 2 diabetes». Diabetes Care. Noviembre de 2004; 27
(11): 2628-
2635. 18- Nauck, M. A., Meininger, G., Sheng, D., Terranella, L. y Stein, P. P. «Efficacy a
nd safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with
the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled
on metformin alone: a randomized, double-blind, non-
inferiority trial». Diabetes, Obe- sity and Metabolism. Marzo de 2007; 9 (2): 194-
205. 19- Meneilly, G. S. et al. «Effect of acarbose on insulin sensitivity in elderly patients
with diabetes». Diabetes Care. Agosto de 2000; 23 (8): 1162-
1167. 20- Wolever, T. M., Chiasson, J. L., Josse, R. G., Hunt, J. A., Palmason, C., Rodger,
N. W., Ross, S. A., Ryan, E. A. y Tan, M. H. «Small weight loss on long-term acarbose
therapy with no change in dietary pattern or nutrient intake of individuals with non-
insulindependent diabetes». International Journal of Obesity and Related Meta- bolic Disor
ders. Septiembre de 1997; 21 (9): 756-
763. 21- Polidori, D. et al. «Canagliflozin lowers postprandial glucose and insulin by delayi
ng intestinal glucose absorption in addition to increasing urinary
glucose excretion: results of a randomized, placebo-
controlled study». Diabetes Care. Agos- to de 2013; 36 (8): 2154-
2156. 22- Bolinder, J. et al. «Effects of dapagliflozin on body weight, total fat mass, and re
gional adipose tissue distribution in patients with type 2 diabetes mellitus
with inadequate glycemic control on metformin». The Journal of Clinical Endocrinology &
Metabolism. Marzo de 2012; 97 (3): 1020-
1031. 23- Nuack, M. A. et al. «Dapagliflozin versus glipizide as add-
on therapy in patients with type 2 diabetes who have inadequate glycemic control with metf
ormin». Dia- betes Care. Septiembre de 2011; 34 (9): 2015-2022.
24- Domecq, J. P. et al. «Drugs commonly associated with weight change: a systematic re
view and meta-analysis». The Journal of Clinical Endocrinology & Metabolism. Febrero de
2015; 100 (2): 363-
370. 25- Ebenbichler, C. F. et al. «Olanzapine induces insulin resistance: results from a pro
spective study». Journal of Clinical Psychiatry. Diciembre de 2003; 64 (12): 1436- 1439. 2
6- Scholl, J. H., van Eekeren y van Puijenbroek, E. P. «Six cases of (severe) hy- poglycaem
ia associated with gabapentin use in both diabetic and non-diabetic
patients». British Journal of Clinical Pharmacology. 11 de noviembre de 2014. DOI: 10.1
111/bcp.12548. [Publicación en línea previa a la impresa]. Fecha de la consulta: 6 de abril
de
2015. 27- Penumalee, S., Kissner, P. y Migdal, S. «Gabapentin induced hypoglycemia in a l
ongterm peritoneal dialysis patient». American Journal of Kidney Deseases. Diciem- bre de
2003; 42 (6): E3-5. 28- Suzuki, Y. et al. «Quetiapine-
induced insulin resistance after switching from blonanserin despite a loss in both bodyweig
ht and waist circumference». Psychiatry and Clinical Neurosciences. Octubre de 2012; 66 (
6): 534-
535. 29- Kong, L. C. et al. «Insulin resistance and inflammation predict kinetic body we- ig
ht changes in response to dietary weight loss and maintenance in overweight
and obese subjects by using a Bayesian network approach». The American Journal of Cli- n
ical Nutrition. Diciembre de 2013; 98 (6): 1385-
1394. 30- Lustig, R. H. et al. «Obesity, leptin resistance, and the effects of insulin su- ppres
sion». International Journal of Obesity. 17 de agosto de 2004; 28: 1344-
1348. 31- Martin, S. S., Qasim, A. y Reilly, M. P. «Leptin resistance: a possible interface of
inflammation and metabolism in obesity-
related cardiovascular disease». Journal of the American College of Cardiology. 7 de octubre de
2008; 52 (15): 1201-
1210. 32- Benoit, S. C., Clegg, D. J., Seeley, R. J. y Woods, S. C. «Insulin and leptin as adiposity si
gnals». Recent Progress in Hormone Research. 2004; 59: 267-285.
NOTAS 1- Owen, O. E. y Cahill, G. F. Jr. «Metabolic effects of exogenous glucocorticoid

s in fasted man». The Journal of Clinical Investigation. Octubre de 1973; 52 (10): 2596- 26
00. 2- Rosmond, R. et al. «Stress-
related cortisol secretion in men: relationships with abdominal obesity and endocrine,
metabolic and hemodynamic
abnormalities». The Journal of Clinical Endocrinology & Metabolism. Junio de 1998; 83 (6
): 1853-1859. 3- Whitworth, J. A. et al. «Hyperinsulinemia is not a cause of cortisol-
induced hypertension». American Journal of Hypertension. Junio de 1994; 7 (6): 562-
565. 4- Pagano, G. et al. «An in vivo and in vitro study of the mechanism of predniso- nein
duced insulin resistance in healthy subjects». The Journal of Clinical Investigation. Noviem
bre de 1983; 72 (5): 1814-1820. 5- Rizza, R. A., Mandarino, L. J. y Gerich, J. E. «Cortisol-
induced insulin resistance in man: impaired suppression of glucose production and
stimulation of
glucose utilization due to a postreceptor detect of insulin action». The Journal of Clinical E
ndocrinology & Metabolism. Enero de 1982; 54 (1): 131-
138. 6- Ferris, H. A. y Kahn, C. R. «New mechanisms of glucocorticoid-
induced insulin resistance: make no bones about it». The Journal of Clinical Investigation.
Noviem- bre de 2012; 122 (11): 3854-
3857. 7- Stolk, R. P. et al. «Gender differences in the associations between cortisol and ins
ulin in healthy subjects». Journal of Endocrinology. Mayo de 1996; 149 (2): 313- 318. 8- Ji
ndal, R. M. et al. «Posttransplant diabetes mellitus: a review». Transplantation. 27 de
diciembre de 1994; 58 (12): 1289-
1298. 9- Pagano, G. et al. «An in vivo and in vitro study of the mechanism of
prednisone-
induced insulin resistance in healthy subjects». The Journal of Clinical Investigation. Novie
mbre de 1983; 72 (5): 1814-
1820. 10- Rizza, R. A., Mandarino, L. J. y Gerich, J. E. «Cortisol-
induced insulin resistance in man: impaired suppression of glucose production and
stimulation of
glucose utilization due to a postreceptor defect of insulin action». The Journal of Clinical E
ndocrinology & Metabolism. Enero de 1982; 54 (1): 131-
138. 11- Dinneen, S., Alzaid, A., Miles, J. y Rizza, R. «Metabolic effects of the nocturnal ri
se in cortisol on carbohydrate metabolism in normal humans». The Journal of Cli- nical Inv
estigation. Noviembre de 1993; 92 (5): 2283-
2290. 12- Lemieux, I. et al. «Effects of prednisone withdrawal on the new metabolic triad i
n cyclosporine-treated kidney transplant patients». Kidney International. Noviem- bre de
2002; 62 (5): 1839-
1847. 13- Fauci, A. et al., editores. Harrison’s principles of internal medicine. 17.ª ed. Mc
Graw-
Hill Professional, 2008, p. 2255. (En castellano: Harrison. Principios de medicina interna,
2 volúmenes [19.ª ed.]. España: McGraw-
Hill, 2015). 14- Tauchmanova, L. et al. «Patients with subclinical Cushing’s syndrome due
to adrenal adenoma have increased cardiovascular risk». The Journal of Clinical Endo- crin
ology & Metabolism. Noviembre de 2002; 87 (11): 4872-
4878. 15- Fraser, R. et al. «Cortisol effects on body mass, blood pressure, and cholesterol i
n the general population». Hypertension. Junio de 1999; 33 (6): 1364-
1368. 16- Marin, P. et al. «Cortisol secretion in relation to body fat distribution in obese pre
menopausal women». Metabolism. Agosto de 1992; 41 (8): 882-
886. 17- Wallerius, S. et al. «Rise in morning saliva cortisol is associated with abdominal o
besity in men: a preliminary report». Journal of Endocrinological Investigation. Julio de
2003; 26 (7): 616-619.
18- Wester, V. L. et al. «Long-
term cortisol levels measured in scalp hair of obese patients». Obesity (Silver Spring). Septi
embre de 2014; 22 (9): 1956-1958. DOI: 10.1002/oby.20795. Fecha de la consulta: 6 de
abril de
2015. 19- Fauci, A. et al., editores. Harrison’s principles of internal medicine. 17.ª ed. Mc
Graw-
Hill Professional, 2008, p. 2263. (En castellano: Harrison. Principios de medicina interna,
2 volúmenes [19.ª ed.]. España: McGraw-
Hill, 2015). 20- Daubenmier, J. et al. «Mindfulness intervention for stress eating to reduce
cortisol and abdominal fat among overweight and obese women». Journal of Obesity. 2011
; artículo ID 651936. Fecha de la consulta: 6 de abril de 2015. 21- Knutson, K. L., Spiegel,
K., Penev, P. y van Cauter, E. «The metabolic consequences of sleep deprivation». Sleep
Medicine Reviews. Junio de 2007; 11 (3): 163- 178. 22- Webb, W. B. y Agnew, H. W. «Are
we chronically sleep deprived?» Bulletin of the Psychonomic Society. 1975; 6 (1): 47-
48. 23- Bliwise, D. L. «Historical change in the report of daytime fatigue». Sleep. Julio de
1996; 19 (6): 462-
464. 24- Watanabe, M. et al. «Association of short sleep duration with weight gain and obe
sity at 1-year follow-up: a large-scale prospective study». Sleep. Febrero de 2010; 33 (2):
161-
167. 25- Hasler, G., Buysse, D., Klaghofer, R., Gamma, A. y Ajdacic, V. et al. «The asso- c
iation between short sleep duration and obesity in young adults: A 13-year
prospective study». Sleep. 15 de junio de 2004; 27 (4): 661-
666. 26- Cappuccio, F. P. et al. «Meta-
analysis of short sleep duration and obesity in children and adults». Sleep. Mayo de 2008; 3
1 (5): 619-
626. 27- Joo, E. Y. et al. «Adverse effects of 24 hours of sleep deprivation on cognition
and stress hormones». Journal of Clinical Neurology. Junio de 2012; 8 (2): 146-
150. 28- Leproult, R. et al. «Sleep loss results in an elevation of cortisol levels the next eve
ning». Sleep. Octubre de 1997; 20 (10): 865-
870. 29- Spiegel, K., Knutson, K., Leproult, R., Tasali, E. y Cauter, E. V. «Sleep loss: a no
vel risk factor for insulin resistance and Type 2 diabetes». Journal of Applied Physiology. N
oviembre de 2005; 99 (5): 2008-
2019. 30- Van Helder, T., Symons, J. D. y Radomski, M. W. «Effects of sleep deprivation a
nd exercise on glucose tolerance». Aviation, Space, and Environmental Medicine. Junio de
1993; 64 (6): 487-492. 31- «Sub-
chronic sleep restriction causes tissue specific insulin resistance». The Journal of Clinical E
ndocrinology & Metabolism. 6 de febrero de 2015; jc20143911 [publicación en línea previa
a la impresión]. Fecha de la consulta: 6 de abril
de 2015. 32- Kawakami, N., Takatsuka, N. y Shimizu, H. «Sleep disturbance and onset of t
ype 2 diabetes». Diabetes Care. Enero de 2004; 27 (1): 282-
283. 33- Taheri, S., Lin, L., Austin, D., Young, T. y Mignot, E. «Short sleep duration is ass
ociated with reduced leptin, elevated ghrelin, and increased body mass
index». PLoS Medicine. Diciembre de 2004; 1 (3): e62. 34- Nedeltcheva, A. V. et al. «Insuf
ficient sleep undermines dietary efforts to reduce adiposity». Annals of Internal Medicine.
5 de octubre de 2010; 153 (7): 435-
441. 35- Pejovic, S. et al. «Leptin and hunger levels in young healthy adults after one night
of sleep loss». Journal of Sleep Research. Diciembre de 2010; 19 (4): 55255- 55258.
NOTAS 1- Pennington, A. W. «A reorientation on obesity». The New England Journal of

Medicine. 4 de junio de 1953; 248 (23): 959-
964. 2- Bloom, W. L., Azar, G., Clark, J. y MacKay, J. H. «Comparison of metabolic chan-
ges in fasting obese and lean patients». Annals of the New York Academy of Sciences. 8 de
octubre de 1965; 131 (1): 623-
631. 3- Stillman, I. The Doctor’s Quick Weight Loss Diet. Ishi Press, 2011. 4- Kolata, G. Re
thinking thin: the new science of weight loss –
and the myths and reali- ties of dieting. Nueva York (EUA): Picador, 2008. 5- Samaha, F. F
. et al. «A low-carbohydrate as compared with a low-
fat diet in severe obesity». The New England Journal of Medicine. 22 de mayo de 2003; 3
48 (21): 2074-
2081. 6- Gardner, C. D. et al. «Comparison of the Atkins, Zone, Ornish, and LEARN diets
for change in weight and related risk factors among overweight
premenopausal women». The Journal of the American Medical Association. 7 de marzo de
2007; 297 (9): 969-977. 7- Shai, I. et al. «Weight loss with a low-
carbohydrate, Mediterranean, or low-
fat die». The New England Journal of Medicine. 17 de julio de 2008; 359 (3): 229-
241. 8- Larsen, T. M. et al. «Diets with high or low protein content and glycemic index for
weight-loss maintenance». The New England Journal of Medicine. 25 de noviembre de
2010; 363 (22): 2102-
2113. 9- Ebbeling, C. et al. «Effects of dietary composition on energy expenditure during w
eight-loss maintenance». The Journal of the American Medical Association. 27 de junio de
2012; 307 (24): 2627-2634. 10- Boden, G. et al. «Effect of a low-
carbohydrate diet on appetite, blood glucose
levels, and insulin resistance in obese patients with type 2 diabetes». Annals of Internal Me
dicine. 15 de marzo de 2005; 142 (6): 403-
411. 11- Foster, G. et al. «Weight and metabolic outcomes after 2 years on a low- carbohyd
rate versus low-fat diet». Annals of Internal Medicine. 3 de agosto de 2010; 153 (3): 147-
157. 12- Shai, I. et al. «Four-year follow-up after two-
year dietary interventions». The New England Journal of Medicine. 4 de octubre de 2012; 3
67 (14): 1373-
1374. 13- Hession, M. et al. «Systematic review of randomized controlled trials of lowcar-
bohydrate vs. low-fat/low calorie diets in the management of obesity and its
co- morbidities». Obesity Reviews. Enero de 2009; 10 (1): 36-
50. 14- Zhou, B. G. et al. «Nutrient intakes of middle-
aged men and women in China, Japan, United Kingdom, and United States in the late
1990s: The
INTERMAP Study». Journal of Human Hypertension. Septiembre de 2003; 17 (9): 623-
630. 15- Fuente de los datos de la figura 9.1: Ibid. 16- Lindeberg, S. et al. «Low serum insu
lin in traditional Pacific Islanders: the Ki- tava Study». Metabolism. Octubre de 1999; 48 (1
0): 1216-1219.
NOTAS 1- Tirosh, A. et al. «Adolescent BMI trajectory and risk of diabetes versus corona
ry disease». The New England Journal of Medicine. 7 de abril de 2011; 364 (14): 1315- 132
5. 2- Alexander Fleming. «Penicillin». Conferencia al obtener el Premio Nobel, diciembre
de 1945. Puede leerse
en www.nobelprize.org/nobel_prizes/medicine/laureates/1945/fleming-lecture.pdf. Fecha
de la consulta: 15 de abril de
2015. 3- Pontiroli, A. E., Alberetto, M. y Pozza G. «Patients with insulinoma show insulin r
esistance in the absence of arterial hypertension». Diabetologia. Marzo de 1992; 35 (3):
294-
295. 4- Pontiroli, A. E., Alberetto, M., Capra, F. y Pozza, G. «The glucose clamp tech- niqu
e for the study of patients with hypoglycemia: insulin resistance as a feature
of insulinoma». Journal of Endocrinological Investigation. Marzo de 1990; 13 (3): 241- 24
5. 5- Ghosh, S. et al. «Clearance of acanthosis nigricans associated with insulinoma followi
ng surgical resection». QJM. Noviembre de 2008; 101 (11): 899-
900. DOI: 10.1093/qjmed/hcn098. Publicado en línea el 31 de julio de 2008. Fecha de la
consulta: 8 de abril de
2015. 6- Rizza, R. A. et al. «Production of insulin resistance by hyperinsulinemia in man».
Diabetologia. Febrero de 1985; 28 (2): 70-
75. 7- Del Prato, S. et al. «Effect of sustained physiologic hyperinsulinemia and hy- pergly
cemia on insulin secretion and insulin sensitivity in man». Diabetologia. Octubre de 1994;
37 (10): 1025-
1035. 8- Henry, R. R. et al. «Intensive conventional insulin therapy for type II diabetes».
Diabetes Care. Enero de 1993; 16 (1): 23-
31. 9- Le Stunff, C. y Bougneres, P. «Early changes in postprandial insulin secretion, not in
insulin sensitivity characterize juvenile obesity». Diabetes. Mayo de 1994; 43 (5): 696-
702. 10- Popkin, B. M. y Duffey, K. J. «Does hunger and satiety drive eating anymore?». T
he American Journal of Clinical Nutrition. Mayo de 2010; 91 (5): 1342-
1347. 11- Duffey, K. J. y Popkin, B. M. «Energy density, portion size, and eating occasions
: contributions to increased energy intake in the United States, 1977-
2006». PLoS Med. Junio de 2011; 8 (6): e1001050. DOI: 10.1371/journal.pmed.1001050. F
echa de la consulta: 8 de abril de
2015. 12- Bellisle, F., McDevitt, R. y Prentice, A. M. «Meal frequency and energy balance
». British Journal of Nutrition. Abril de 1997; 77 supl. 1: S57-
70. 13- Cameron, J. D., Cyr, M. J. y Doucet, E. «Increased meal frequency does not pro- m
ote greater weight loss in subjects who were prescribed an 8-week equi-energetic energy-
restricted diet». British Journal of Nutrition. Abril de 2010; 103 (8): 1098-
1101. 14- Leidy, J. H. et al. «The influence of higher protein intake and greater eating fre- q
uency on appetite control in overweight and obese men». Obesity (Silver Spring). Septiemb
re de 2010; 18 (9): 1725-
1732. 15- Stewart, W. K. y Fleming, L. W. «Features of a successful therapeutic fast of 382
days’ duration». Postgraduate Medical Journal. Marzo de 1973; 49 (569): 203-209.
NOTAS 1- Center for Science in the Public Interest [Internet]. «Non-

profit organizations receiving corporate
funding». 2- Freedhoff, Y. Blog Weighty Matters [Internet]. «Heart and Stroke Foundation
Health Check on 10 teaspoons of sugar in a glass». 9 de abril de 2012. Puede
leerse en www.weightymatters.ca/2012/04/heart-and-stroke-foundation-
health.html. Fecha de la consulta: 8 de abril de
2015. 3- Lesser, L. I., Ebbeling, C. B., Goozner, M., Wypij, D. y Ludwig, D. «Relationship
between funding source and conclusion among nutrition-related scientific
articles». PLoS Med. 9 de enero de 2007; 4 (1): e5. DOI: 10.1371/ journal.pmed.0040005.
Fecha de la consulta: 8 de abril de
2015. 4- Nestle, M. «Food company sponsorship of nutrition research and professional acti
vities: A conflict of interest?». Public Health Nutrition. Octubre de 2001; 4 (5): 1015-
1022. 5- Stubbs, R. J., Mazlan, N. y Whybrow, S. «Carbohydrates, appetite and feeding beh
avior in humans». The Journal of Nutrition. 1 de octubre de 2001; 131 (10): 2775- 2781S. 6
- Cameron, J. D., Cyr, M. J. y Doucet, E. «Increased meal frequency does not pro- mote
greater weight loss in subjects who were prescribed an 8-week equi-
energetic energyrestricted diet». British Journal of Nutrition. Abril de 2010; 103 (8): 1098-
1101. 7- Wyatt, H. R. et al. «Long-
term weight loss and breakfast in subjects in the Natio- nal Weight Control Registry». Obes
ity Research. Febrero de 2002; 10 (2): 78-
82. 8- Wing, R. R. y Phelan, S. «Long term weight loss maintenance». The American Journ
al of Clinical Nutrition. Julio de 2005; 82 (1 supl.): 222S-
2225S. 9- Brown, A. W. et al. «Belief beyond the evidence: using the proposed effect of
breakfast on obesity to show 2 practices that distort scientific evidence». The Ame- rican Jo
urnal of Clinical Nutrition. Noviembre de 2013; 98 (5): 1298-
1308. 10- Schusdziarra, V. et al. «Impact of breakfast on daily energy intake». Nutrition Jo
urnal. 17 de enero de 2011; 10: 5. DOI: 10.1186/1475-2891-10-5. Fecha de la consulta: 8
de abril de
2015. 11- Reeves, S. et al. «Experimental manipulation of breakfast in normal and overwe-
ight/obese participants is associated with changes to nutrient and energy
intake consumption patterns». Physiology & Behavior. 22 de junio de 2014; 133: 130-
135. DOI: 10.1016/j.physbeh.2014.05.015. Fecha de la consulta: 8 de abril de
2015. 12- Dhurandhar, E. et al. «The effectiveness of breakfast recommendations on we- ig
ht loss: a randomized controlled trial». The American Journal of Clinical Nutrition. 4 de
junio de 2014. DOI: 10.3945/ajcn.114.089573. Fecha de la consulta: 8 de abril de
2015. 13- Betts, J. A. et al. «The causal role of breakfast in energy balance and health: a ran
domized controlled trial in lean adults». The American Journal of Clinical Nutrition. Agost
o de 2014; 100 (2): 539-
547. 14- «Diet, nutrition and the prevention of chronic disease: report of a joint WHO/ FA
O expert consultation». Ginebra: World Health Organization, 2003, p. 68.
Puede leerse en http://apps.who.int/iris/bitstream/10665/42665/1/WHO_TRS_916.pdf. Fec
ha de la consulta: 9 de abril de
2015. 15- Kaiser, K. A. et al. «Increased fruit and vegetable intake has no discernible effect
on weight loss: a systematic review and meta-
analysis». The American Journal of Cli- nical Nutrition. Agosto de 2014; 100 (2): 567-
576. 16- Muraki, I. et al. «Fruit consumption and the risk of type 2 Diabetes». BMJ. 28 de
agosto de 2013; 347: f5001. DOI: 10.1136/bmj.f5001. Fecha de la consulta: 8 de abril de
2015.
NOTAS 1- Centers for Disease Control and Prevention. «Obesity trends among U.S. adult
s between 1985 and 2010». Puede leerse
en www.cdc.gov/obesity/downloads/obesity_trends_2010.ppt. Fecha de la consulta: 26 de
abril de
2015. 2- United States Census Bureau [Internet]. «State and country quick facts». Actua- liz
ado el 24 de marzo de 2015. Puede leerse
en www.census.gov/quickfacts/fact/table/US/PST045216. Fecha de la consulta: 8 de abril
de
2015. 3- Levy, J. «Mississippians most obese, Montanans least obese». Gallup [Internet]. P
uede leerse en www.gallup.com/poll/167642/mississippians-obese-montanans-least-
obese.aspx. Fecha de la consulta: 8 de abril de
2015. 4- Michael Moss. Salt Sugar Fat: How the Food Giants Hooked Us. Toronto (Canad
á): Signal Publishing, 2014. (En castellano: Adictos a la comida basura. Es- paña: Deusto
S. A. Ediciones,
2016). 5- David Kessler. The End of Overeating: Taking Control of the Insatiable North A
merican Appetite. Toronto (Canadá): McClelland & Stewart Publishing, 2010. 6- Fuente d
e los datos de la figura 12.2: Environmental Working Group (EWG). «EWG farm subsidies
». Puede encontrarse en http://farm.ewg.org/. Fecha de la consulta: 26 de abril de
2015. 7- Russo, M. «Apples to twinkies: comparing federal subsidies of fresh produce and j
unk food». U.S. PIRG Education Fund. Septiembre de 2011. Puede leerse en www.foodsaf
etynews.com/files/2011/09/Apples-to-Twinkies-USPIRG.pdf. Fecha de la consulta: 26 de
abril de 2015.
8- Fuente de los datos de la figura 12.3: Ibid. 9- Mills, C. A.: «Diabetes mellitus: is climate
a responsible factor in the etiology?». Archives of Internal Medicine. Octubre de 1930; 46 (
4): 569-
581. 10- Marchand, L. H. «The Pima Indians: Obesity and diabetes». National Diabetes Inf
ormation Clearinghouse (NDICH) [Internet]. Puede leerse en www.ncbi.nlm.nih.gov/pubm
ed/10959174. Fecha de la consulta: 8 de abril de 2015. 11- U.S. PIRG [Internet]. «Report: 2
1st century transportation». 14 de mayo de 2013. Puede leerse en http://uspirg.org/reports/u
sp/new-direction. Fecha de la consulta: 8 de abril de
2015. 12- Davies, A. «The age of the car in America is over». Business Insider [Internet]. 2
0 de mayo de 2013. www.businessinsider.com/the-us-driving-boom-is-over-2013-5. Fecha
de la consulta: 8 de abril de 2015.
NOTAS *- El equivalente a 6º de primaria y 1º y 2º de ESO (N. del T.). 1- Foster, G. D. et

al. «The HEALTHY Study Group. A school-
based intervention for diabetes risk reduction». The New England Journal of Medicine. 29
de julio de 2010; 363 (5): 443-
453. 2- Must, A., Jacques, P. F., Dallal, G. E., Bajema, C. J. y Dietz, W. H. «Long-
term morbidity and mortality of overweight adolescents: a follow-up of the Harvard
Gro- wth Study of 1922 to 1935». The New England Journal of Medicine. Noviembre de 19
92; 327 (19): 1350-1355. 3- Deshmukh-
Taskar, P., Nicklas, T. A., Morales, M., Yang, S. J., Zakeri, I. y Beren- son, G. S.
«Tracking of overweight status from childhood to young adulthood:
the Bogalusa Heart Study». European Journal of Clinical Nutrition. Enero de 2006; 60 (1):
48-57. 4- Baker, J. L., Olsen, L. W. y Sorensen, T. I. «Childhood body-
mass index and the risk of coronary heart disease in adulthood». The New England Journal
of Medicine. Diciembre de 2007; 357 (23): 2329-
2337. 5- Juonala, M. et al. «Childhood adiposity, adult adiposity, and cardiovascular risk fa
ctors». The New England Journal of Medicine. 17 de noviembre de 2011; 365 (20): 1876-
1885. 6- Kim, J. et al. «Trends in overweight from 1980 through 2001 among preschool- ag
ed children enrolled in a health maintenance organization». Obesity (Silver Spring). Julio
de 2006; 14 (7): 1107-
1112. 7- Bergmann, R. L. et al. «Secular trends in neonatal macrosomia in Berlin: influen-
ces of potential determinants». Paediatric and Perinatal Epidemiology. Julio de 2003; 17
(3): 244-249.
8- Holtcamp, W. «Obesogens: an environmental link to obesity». Environmental Health Pe
rspectives. Febrero de 2012; 120 (2): a62-
a68. 9- Ludwig, D. S. y Currie, J. «The association between pregnancy weight gain and birt
h weight». The Lancet. 18 de septiembre de 2010; 376 (9745): 984-
990. 10- Whitaker, R. C. et al. «Predicting obesity in young adulthood from childhood and
parental obesity». The New England Journal of Medicine. 25 de septiembre de 1997; 337
(13): 869-873. 11- Caballero, B. et al. «Pathways: A school-
based randomized controlled trial for the prevention of obesity in American Indian schoolc
hildren». The American Journal of Clinical Nutrition. Noviembre de 2003; 78 (5): 1030-
1038. 12- Nader, P. R. et al. «Three-
year maintenance of improved diet and physical activity: the CATCH cohort». Archives of
Pediatrics and Adolescent Medicine. Julio de 1999; 153 (7): 695-
705. 13- Klesges, R. C. et al. «The Memphis Girls Health Enrichment Multi-
site Studies (GEMS)». Archives of Pediatrics and Adolescent Medicine. Noviembre de 201
0; 164 (11): 1007-1014. 14- De Silva-
Sanigorski, A. M. et al. «Reducing obesity in early childhood: results from Romp & Chom
p, an Australian community-
wide intervention program». The American Journal of Clinical Nutrition. Abril de 2010; 91
(4): 831-
840. 15- James, J. et al. «Preventing childhood obesity by reducing consumption of carbona
ted drinks: cluster randomised controlled trial». BMJ. 22 de mayo de 2004; 328 (7450):
1237. 16- Ogden, C. L. et al. «Prevalence of childhood and adult obesity in the United State
s, 2011-2012». The Journal of the American Medical Association. 26 de febrero de 2014;
311 (8): 806-814.
17- Spock, B. Baby and Child Care. Pocket Books, 1987, p. 536. (En castellano: Tu hijo. Barcelona
[España]: Ediciones B, S. A., 2007).
NOTAS 1- Suddath, C. y Stanford, D. «Coke confronts its big fat problem». Bloomberg B
usi- nessweek [Internet]. 31 de julio de 2014. Puede leerse en www.bloomberg.com/bw/arti
cles/2014-07-31/coca-cola-sales-decline-health-concerns-spur-relaunch. Fecha de la
2015. 2- Ibid. 3- S&D (Group Sucres et Denrées) [Internet]. «World sugar consumption». 4
- Xu, Y. et al. «Prevalence and control of diabetes in Chinese adults». The Journal of the A
merican Medical Association. 4 de septiembre de 2013; 310 (9): 948-
959. 5- Loo, D. «China “catastrophe” hits 114 million as diabetes spreads». Bloomberg Ne
ws [Internet]. 3 de septiembre de 2013. Puede leerse en www.bloomberg.com/news/articles/
2013-09-03/china-catastrophe-hits-114-million-as-diabetes-spreadsdiabetes-spreads. Fecha
de la consulta: 8 de abril de
2015. 6- Huang, Y. «China’s looming diabetes epidemic». The Atlantic [Internet]. 13 de se
ptiembre de 2013. Puede leerse www.theatlantic.com/china/archive/2013/09/chinas-
looming-diabetes-epidemic/279670/diabetes-epidemic/279670/. Fecha de la consulta: 8 de
abril de 2015. 7- Schulze, M. B. et al. «Sugar-
sweetened beverages, weight gain and incidence of type 2 diabetes in young and middle ag
ed women». The Journal of the American Medical Association. 25 de agosto de 2004; 292 (
8): 927-
934. 8- Basu, S., Yoffe, P., Hills, N. y Lustig, R. H. «The relationship of sugar to popu- lati
on-level diabetes prevalence: an econometric analysis of repeated
cross- sectional data». PLoS One [Internet]. 2013; 8 (2): e57873. DOI: 10.1371/ journal.pon
e.0057873. Fecha de la consulta: 8 de abril de
2015. 9- Lyons, R. D. «Study insists diabetics can have some sugar». The New York Times
[Internet]. 7 de julio de 1983. Puede leerse en www.nytimes.com/1983/07/07/us/study-
insists-diabetics-can-have-some-sugar.html. Fecha de la consulta: 8 de abril de
2015. 10- Glinsmann, W. H. et al. «Evaluation of health aspects of sugars contained in carb
ohydrate sweeteners». The Journal of Nutrition. Noviembre de 1986; 116 (11S): S1-
S216. 11- National Research Council (US) Committee on Diet and Health. «Diet and heal- t
h: implications for reducing chronic disease risk». Washington, DC (EUA): Natio- nal
Academies Press (U.S.), 1989, p.
7. 12- American Diabetes Association [Internet]. «Sugar and desserts». Editado el 27 de
enero de 2015. Puede leerse en http://www.diabetes.org/food-and-fitness/food/planning-
meals/holiday-meal-planning/making-sugar-count-during-the-holidays.html. Fecha de la
consulta: 8 de abril de 2015. 13- Zhou, B. F. et al. «Nutrient intakes of middle-
aged men and women in China, Japan, United Kingdom, and United States in the late 1990
s». Journal of Human Hypertension. Septiembre de 2003; 17 (9): 623-
630. 14- Duffey, K. J. y Popkin, B. M. «High-
Fructose Corn syrup: Is this what’s for din- ner?». The American Journal of Clinical Nutriti
on. 2008; 88 (supl.): 1722S-
1732S. 15- Bray, G. A., Nielsen, S. J. y Popkin, B. M. «Consumption of high-
fructose corn syrup in beverages may play a role in the epidemic of obesity». The American
Jour- nal of Clinical Nutrition. Abril de 2004; 79 (4): 537-543. 16- Beck-
Nielsen, H. et al. «Impaired cellular insulin binding and insulin sensitivity induced by high-
fructose feeding in normal subjects». The American Journal of Cli- nical Nutrition. Febrero
de 1980; 33 (2): 273-278. 17- Stanhope, K. L. et al. «Consuming fructose-
sweetened, not glucose-sweetened,
beverages increases visceral adiposity and lipids and decreases insulin
sensitivity in overweight/obese humans». JCI. 1 de mayo de 2009; 119 (5): 1322-
1334. 18- Sievenpiper, J. L. et al. «Effect of fructose on body weight in controlled feeding trials: a s
ystematic review and meta-analysis». Annals of Internal Medicine. 21 de febrero de 2012; 156 (4):
291-
304. 19- Ogden, C. L. et al. «Prevalence of childhood and adult obesity in the United States, 2011-
2012». The Journal of the American Medical Association. 26 de febrero de 2014; 311 (8): 806-
814. 20- Geiss, L. S. et al. «Prevalence and incidence trends for diagnosed diabetes among adults ag
ed 20 to 79 years, United States, 1980-
2012». The Journal of the American Medical Association. 24 de septiembre de 2014; 312 (12): 121
8-1226.
NOTAS 1- Yang, Q. «Gain weight by “going diet”? Artificial sweeteners and the neuro- bi
ology of sugar cravings». Yale Journal of Biology and Medicine. Junio de 2010; 83 (2):
101-
108. 2- Mattes, R. D. y Popkin, B. M. «Nonnutritive sweetener consumption in humans: eff
ects on appetite and food intake and their putative mechanisms». The American Journal of
Clinical Nutrition. Enero de 2009; 89 (1): 1-14. (Este artículo es también la fuente de los
datos de la figura
15.1). 3- Gardner, C. et al. «Nonnutritive sweeteners: current use and health perspectives: a
scientific statement from the American Heart Association and the American
Dia- betes Association». Circulation. 24 de julio de 2012; 126 (4): 509-
519. 4- Oz, M. «Agave: why we were wrong». The Oz Blog. 27 de febrero de 2014. Puede l
eerse en http://blog.doctoroz.com/dr-oz-blog/agave-why-we-were-wrong. Fecha de la
2015. 5- Gardner, C. et al. «Nonnutritive sweeteners: current use and health perspectives: a
scientific statement from the American Heart Association and the American
Dia- betes Association». Circulation. 24 de julio de 2012; 126 (4): 509-
519. 6- American Diabetes Association [Internet]. «Low calorie sweeteners». Editado el 16
de diciembre de 2014. 7- Stellman, S. D. y Garfinkel, L. «Artificial sweetener use and one-
year weight change among women». Preventive Medicine. Marzo de 1986; 15 (2): 195-
202. 8- Fowler, S. P. et al. «Fueling the obesity epidemic? Artificially sweetened beverage
use and long-term weight gain». Obesity. Agosto de 2008; 16 (8): 1894-
1900. 9- Gardener, H. et al. «Diet soft drink consumption is associated with an increased ris
k of vascular events in the Northern Manhattan Study». Journal of General
Internal Medicine. Septiembre de 2012; 27 (9): 1120-
1126. 10- Lutsey, P. L., Steffen, L. M. y Stevens, J. «Dietary intake and the development of
the metabolic syndrome: the Atherosclerosis Risk in Communities
Study». Circulation. 12 de febrero de 2008; 117 (6): 754-
761. 11- Dhingra, R., Sullivan, L., Jacques, P. F., Wang, T. J., Fox, C. S., Meigs, J. B., D’A
- gostino, R. B., Gaziano, J. M. y Vasan, R. S. «Soft drink consumption and risk
of developing cardiometabolic risk factors and the metabolic syndrome in
middle- aged adults in the community». Circulation. 31 de julio de 2007; 116 (5): 480-
488. 12- American College of Cardiology. «Too many diet drinks may spell heart trouble fo
r older women, study suggests». Science Daily [Internet]. 29 de marzo de 2014. Puede leers
e en www.sciencedaily.com/releases/2014/03/140329175110.htm. Fecha de la consulta: 9
de abril de
2015. 13- Pepino, M. Y. et al. «Sucralose affects glycemic and hormonal responses to an or
al glucose load». Diabetes Care. Septiembre de 2013; 36 (9): 2530-
2535. 14- Anton, S. D. et al. «Effects of stevia, aspartame, and sucrose on food intake, satie
ty, and postprandial glucose and insulin levels». Appetite. Agosto de 2010; 55 (1): 37-
43. 15- Yang, Q. «Gain weight by “going diet”? Artificial sweeteners and the neuro- biolog
y of sugar cravings». Yale Journal of Biology and Medicine. Junio de 2010; 83 (2): 101-
108. 16- Smeets, P. A. et al. «Functional magnetic resonance imaging of human hypo- thala
mic responses to sweet taste ad calories». The American Journal of Clinical Nutrition. Novi
embre de 2005; 82 (5): 1011-
1016. 17- Bellisle, F. y Drewnowski, A. «Intense sweeteners, energy intake and the control
of body weight». European Journal of Clinical Nutrition. Junio de 2007; 61 (6):
691-700. 18- Ebbeling, C. B. et al. «A randomized trial of sugar-
sweetened beverages and adolescent body weight». The New England Journal of Medicine. 11 de o
ctubre de 2012; 367 (15): 1407-
1416. 19- Blackburn, G. L. et al. «The effect of aspartame as part of a multidisciplinary weight-
control program on short- and long-
term control of body weight». The Ame- rican Journal of Clinical Nutrition. Febrero de 1997; 65 (2
): 409-418. 20- De Ruyter, J. C. et al. «A trial of sugar-
free or sugar sweetened beverages and body weight in children». The New England Journal of Medi
cine. 11 de octubre de 2012; 367 (15): 1397-1406. 21- Bes-
Rastrollo, M. et al. «Financial conflicts of interest and reporting bias regar- ding the association
between sugar-sweetened beverages and weight gain: a
systematic review of systematic reviews». PLoS Medicine. Diciembre de 2013; 10 (12) e1001578.
DOI: 10.1371/journal.pmed.1001578. Fecha de la consulta: 8 de abril de 2015.
NOTAS 1- Fuente de los datos de la figura 16.1: Cordain, L., Eades, M. R. y Eades, M. D.
«Hyperinsulinemic diseases of civilization: more than just Syndrome X». Compa- rative Bi
ochemistry and Physiology: Part A. 2003; 136: 95-112. Puede leerse en www.direct-
ms.org/sites/default/files/Hyperinsulinemia.pdf. Fecha de la consulta: 15 de abril de
2015. 2- Fan, M. S. et al. «Evidence of decreasing mineral density in wheat grain over the l
ast 160 years». Journal of Trace Elements in Medicine and Biology. 2008; 22 (4): 315- 324.
DOI: 10.1016/j.jtemb.2008.07.002. Fecha de la consulta: 8 de abril de 2015. 3- Rubio-
Tapia, A. et al. «Increased prevalence and mortality in undiagnosed celiac disease». Gastro
enterology. Julio de 2009; 137 (1): 88-
93. 4- Thornburn, A., Muir, J. y Proietto, J. «Carbohydrate fermentation decreases hepa- tic
glucose output in healthy subjects». Metabolism. Junio de 1993; 42 (6): 780-
785. 5- Trout, D. L., Behall, K. M. y Osilesi, O. «Prediction of glycemic index for starchy f
oods». The American Journal of Clinical Nutrition. Diciembre de 1993; 58 (6): 873- 878. 6
- Jeraci, J. L. «Interaction between human gut bacteria and fibrous substrates». En: Spiller
G. A., editor. CRC handbook of dietary fiber in human nutrition. Boca Raton (Florida,
EUA): CRC Press, 1993, p.
648. 7- Wisker, E., Maltz, A. y Feldheim, W. «Metabolizable energy of diets low or high in
dietary fiber from cereals when eaten by humans». The Journal of Nutrition. Agos- to de
1988; 118 (8): 945-
952. 8- Eaton, S. B., Eaton, S. B. III, Konner, M. J. y Shostak, M. «An evolutionary perspe
ctive enhances understanding of human nutritional requirements». The Jour- nal of Nutritio
n. Junio de 1996; 126 (6): 1732-1740.
9- Trowell, H. «Obesity in the Western world». Plant Foods for Man. 1975; 1: 157- 168. 10
- U.S. Department of Agriculture ARS. «CSFII/DHKS data set and documen- tation: the
1994 Continuing Survey of Food Intakes by Individuals and the 1994-96 Diet and Health
Knowledge Survey». Springfield (Virginia, EUA): National Tech- nical Information
Service,
1998. 11- Krauss, R. M. et al. «Dietary guidelines for healthy American adults». Circulatio
n. 1 de octubre de 1996; 94 (7): 1795-
1899. 12- Fuchs, C. S. et al. «Dietary fiber and the risk of colorectal cancer and adenoma in
women». The New England Journal of Medicine. 21 de enero de 1999; 340 (3): 169-
176. 13- Alberts, D. S. et al. «Lack of effect of a high-
fiber cereal supplement on the recu- rrence of colorectal adenomas». The New England Jou
rnal of Medicine; 20 de abril de 2000; 342 (16): 1156-
1162. 14- Burr, M. L. et al. «Effects of changes in fat, fish and fibre intakes on death and m
yocardial reinfarction: diet and reinfarction trial (DART)». The Lancet. 30 de septiembre
de 1989; 2 (8666): 757-
761. 15- Estruch, R. «Primary prevention of cardiovascular disease with a Mediterranean di
et». The New England Journal of Medicine. 4 de abril de 2013; 368 (14): 1279-
1290. 16- Miller, W. C. et al. «Dietary fat, sugar, and fiber predict body fat content». Jour-
nal of the American Dietetic Association. Junio de 1994; 94 (6): 612-
615. 17- Nelson, L. H. y Tucker, L. A. «Diet composition related to body fat in a multi- var
iate study of 203 men». Journal of the American Dietetic Association. Agosto de 1996; 96
(8): 771-
777. 18- Gittelsohn, J. et al. «Specific patterns of food consumption and preparation are
associated with diabetes and obesity in a native Canadian community». The Journal of Nutr
ition. Marzo de 1998; 128 (3): 541-
547. 19- Ludwig, D. S. et al. «Dietary fiber, weight gain, and cardiovascular disease risk fa
ctors in young adults». The Journal of the American Medical Association. 27 de octubre de
1999; 282 (16): 1539-1546. 20- Pereira, M. A. y Ludwig, D. S. «Dietary fiber and body-
weight regulation». Pediatric Clinics of North America. Agosto de 2001; 48 (4): 969-
980. 21- Chandalia, M. et al. «Beneficial effects of high fibre intake in patients with type 2
diabetes mellitus». The New England Journal of Medicine. 11 de mayo de 2000; 342 (19):
1392-
1398. 22- Liese, A. D. et al. «Dietary glycemic index and glycemic load, carbohydrate and
fiber intake, and measure of insulin sensitivity, secretion and adiposity in the
Insu- lin Resistance Atherosclerosis Study». Diabetes Care. Diciembre de 2005; 28 (12): 2
832-
2838. 23- Schulze, M. B. et al. «Glycemic index, glycemic load, and dietary fiber intake an
d incidence of type 2 diabetes in younger and middle-
aged women». The Ame- rican Journal of Clinical Nutrition. Agosto de 2004; 80 (2): 348-
356. 24- Salmeron, J. et al. «Dietary fiber, glycemic load, and risk of non- insulindependent
diabetes mellitus in women». The Journal of the American Medical Association. 12 de febr
ero de 1997; 277 (6): 472-
477. 25- Salmeron, J. et al. «Dietary fiber, glycemic load, and risk of NIDDM in men». Dia
betes Care. Abril de 1997; 20 (4): 545-
550. 26- Kolata, G. Rethinking thin: the new science of weight loss –
and the myths and reali- ties of dieting. Nueva York (EUA): Picador, 2007. 27- Johnston, C
. S., Kim, C. M. y Buller, A. J. «Vinegar improves insulin sensitivity
to a highcarbohydrate meal in subjects with insulin resistance or type 2
diabetes». Diabetes Care. Enero de 2004; 27 (1): 281-
282. 28- Johnston, C. S. et al. «Examination of the antiglycemic properties of vinegar in he
althy adults». Annals of Nutrition and Metabolism. 2010; 56 (1): 74-
79. DOI: 10.1159/0002722133. Fecha de la consulta: 8 de abril de
2015. 29- Sugiyama, M. et al. «Glycemic index of single and mixed meal foods among co
mmon Japanese foods with white rice as a reference food». European Journal of Clinical N
utrition. Junio de 2003; 57 (6): 743-
752. 30- Ostman, E. M. et al. «Inconsistency between glycemic and insulinemic responses
to regular and fermented milk products». The American Journal of Clinical Nutrition. Julio
de 2001; 74 (1): 96-
100. 31- Leeman, M. et al. «Vinegar dressing and cold storage of potatoes lowers pos- tpra
ndial glycaemic and insulinaemic responses in healthy subjects». European Journal of Clin
ical Nutrition. Noviembre de 2005; 59 (11): 1266-
1271. 32- White, A. M. y Johnston, C. S. «Vinegar ingestion at bedtime moderates waking
glucose concentrations in adults with well-
controlled type 2 diabetes». Diabetes Care. Noviembre de 2007; 30 (11): 2814-
2815. 33- Johnston, C. S. y Buller, A. J. «Vinegar and peanut products as complementary f
oods to reduce postprandial glycemia». Journal of the American Dietetic Association. Dicie
mbre de 2005; 105 (12): 1939-
1942. 34- Brighenti, F. et al. «Effect of neutralized and native vinegar on blood glucose and
acetate responses to a mixed meal in healthy subjects». European Journal of Cli- nical Nut
rition. Abril de 1995; 49 (4): 242-247. 35- Hu, F. B. et al. «Dietary intake of a-
linolenic acid and risk of fatal ischemic heart disease among women». The American Journ
al of Clinical Nutrition. Mayo de 1999; 69 (5): 890-897.
NOTAS 1- Friedman, et al. «Comparative effects of low-carbohydrate high-

protein versus lowfat diets on the kidney». Clinical Journal of the American Society of Nep
hrology. Julio de 2012; 7 (7): 1103-
1111. 2- Holt, S. H. et al. «An insulin index of foods: the insulin demand generated by 100
0-kJ portions of common foods». The American Journal of Clinical Nutrition. No- viembre
de 1997; 66 (5): 1264-
1276. 3- Floyd, J. C. Jr. «Insulin secretion in response to protein ingestion». The Journal of
Clinical Investigation. Septiembre de 1966; 45 (9): 1479-
1486. 4- Nuttall, F. Q. y Gannon, M. C. «Plasma glucose and insulin response to ma- cronu
trients in non diabetic and NIDDM subjects». Diabetes Care. Septiembre de 1991; 14 (9):
824-838. 5- Nauck, M. et al. «Reduced incretin effect in type 2 (non-insulin-
dependent) diabetes». Diabetologia. Enero de 1986; 29 (1): 46-
52. 6- Pepino, M. Y. et al. «Sucralose affects glycemic and hormonal responses to an oral g
lucose load». Diabetes Care. Septiembre de 2013; 36 (9): 2530-
2535. 7- Just, T. et al. «Cephalic phase insulin release in healthy humans after taste stimulat
ion?». Appetite. Noviembre de 2008; 51 (3): 622-
627. 8- Nilsson, M. et al. «Glycemia and insulinemia in healthy subjects after lactose equiv
alent meals of milk and other food proteins». The American Journal of Clinical Nutrition.
Noviembre de 2004; 80 (5): 1246-
1253. 9- Liljeberg, E. H. y Bjorck, I. «Milk as a supplement to mixed meals may elevate po
stprandial insulinaemia». European Journal of Clinical Nutrition. Noviembre de 2001; 55
(11): 994-999. 10- Nilsson, M. et al. «Glycemia and insulinemia in healthy subjects after
lactose-equivalent meals of milk and other food proteins: the role of plasma
amino acids and incretins». The American Journal of Clinical Nutrition. Noviembre de 200
4; 80 (5): 1246-1253. 11- Jakubowicz, D., Froy, O., Ahren, B., Boaz, M., Landau, Z., Bar-
Dayan, Y., Ganz, T., Barnea, M. y Wainstein, J. «Incretin, insulinotropic and glucose-
lowering effects of whey protein pre-load in type 2 diabetes: a randomized clinical
trial». Diabetologia. Septiembre de 2014; 57 (9): 1807-
1811. 12- Pal, S. y Ellis, V. «The acute effects of four protein meals on insulin, glucose, ap
petite and energy intake in lean men». British Journal of Nutrition. Octubre de 2010; 104
(8): 1241-1248. 13- Fuente de los datos de la figura 17.1: Ibid. 14- Bes-
Rastrollo, M., Sánchez-Villegas, A., Gómez-Gracia, E., Martínez, J. A., Paja- res, R. M. y
Martínez-González, M. A. «Predictors of weight gain in a
Medite- rranean cohort: the Seguimiento Universidad de Navarra Study 1». The American J
ournal of Clinical Nutrition. Febrero de 2006; 83 (2): 362-
370. 15- Vergnaud, A. C. et al. «Meat consumption and prospective weight change in partic
ipants of the EPIC-
PANA CEA study». The American Journal of Clinical Nutrition. Agosto de 2010; 92 (2): 3
98-407. 16- Rosell, M. et al. «Weight gain over 5 years in 21,966 meat-eating, fish-
eating, vegetarian, and vegan men and women in EPIC-
Oxford». International Journal of Obesity (Londres). Septiembre de 2006; 30 (9): 1389-
1396. 17- Mozaffarian, D. et al. «Changes in diet and lifestyle and long-
term weight gain in women and men». The New England Journal of Medicine. 23 de junio
de 2011; 364 (25): 2392-
2404. 18- Cordain, L. et al. «Fatty acid analysis of wild ruminant tissues: evolutionary
implications for reducing diet-
related chronic disease». European Journal of Clinical Nutrition. Marzo de 2002; 56 (3): 181-
191. 19- Rosell, M. et al. «Association between dairy food consumption and weight change over 9 y
in 19,352 perimenopausal women». The American Journal of Clinical Nutrition. Diciembre de 200
6; 84 (6): 1481-
1488. 20- Pereira, M. A. et al. «Dairy consumption, obesity, and the insulin resistance syndrome in
young adults: the CARDIA Study». The Journal of the American Medical Association. 24 de abril d
e 2002; 287 (16): 2081-
2089. 21- Choi, H. K. et al. «Dairy consumption and risk of type 2 diabetes mellitus in men: a prosp
ective study». Archives of Internal Medicine. 9 de mayo de 2005; 165 (9): 997-
1003. 22- Azadbakht, L. et al. «Dairy consumption is inversely associated with the prevalence of t
he metabolic syndrome in Tehranian adults». The American Journal of Cli- nical Nutrition. Septiem
bre de 2005; 82 (3): 523-530. 23- Mozaffarian, D. et al. «Changes in diet and lifestyle and long-
term weight gain in women and men». The New England Journal of Medicine. 23 de junio de 2011;
364 (25): 2392-
2404. 24- Burke, L. E. et al. «A randomized clinical trial testing treatment preference and two
dietary options in behavioral weight management: preliminary results of
the impact of diet at 6 months –PREFER study». Obesity (Silver Spring). Noviembre de 2006; 14
(11): 2007-2017.
NOTAS 1- Keys, A. «Mediterranean diet and public health: personal reflections». The Am
e- rican Journal of Clinical Nutrition. Junio de 1995; 61 (6 supl.): 1321S-
1323S. 2- Nestle, M. «Mediterranean diets: historical and research overview». The Ame- ric
an Journal of Clinical Nutrition. Junio de 1995; 61 (6 supl.): 1313S-
1320S. 3- Keys, A. y Keys, M. Eat well and stay well. Nueva York (EUA): Doubleday & C
om- pany, 1959, p.
40. 4- U.S. Department of Agriculture, U.S. Department of Health and Human Ser- vices. N
utrition and your health: dietary guidelines for Americans. 3.ª ed. Washington, DC (EUA):
U.S. Government Printing Office,
1990. 5- «The Seven Countries Study». Puede leerse en www.sevencountriesstudy.com. Fe
cha de la consulta: 12 de abril de
2015. 6- Howard, B. V. et al. «Low fat dietary pattern and risk of cardiovascular disease: th
e Womens’ Health Initiative Randomized Controlled Dietary Modification
Trial». The Journal of the American Medical Association. 8 de febrero de 2006; 295 (6): 65
5- 666. 7- Yerushalmy, J. y Hilleboe, H. E. «Fat in the diet and mortality from heart disease
: a methodologic note». New York State Journal of Medicine. 15 de julio de 1957; 57 (14):
2343-
2354. 8- Pollan, M. «Unhappy meals». The New York Times [Internet]. 28 de enero de 2007
. Puede leerse en www.nytimes.com/2007/01/28/magazine/28nutritionism.t.html?-
pagewanted=all. Fecha de la consulta: 6 de septiembre de
2015. 9- Simopoulos, A. P. «Omega-
3 fatty acids in health and disease and in growth and development». The American Journal
of Clinical Nutrition. Septiembre de 1991; 54
(3): 438-
463. 10- Eades, M. «Framingham follies». The Blog of Michael R. Eades, M. D. [Internet].
28 de septiembre de 2006. Puede leerse en www.proteinpower.com/drmike/cardiovascular-
disease/framingham-follies/. Fecha de la consulta: 12 de abril de
2015. 11- Nichols, A. B. et al. «Daily nutritional intake and serum lipid levels. The Tecu-
mseh study». The American Journal of Clinical Nutrition. Diciembre de 1976; 29 (12): 138
4-1392. 12- García-
Pamieri, et al. «Relationship of dietary intake to subsequent coronary heart disease incidenc
e: The Puerto Rico Heart Health Program». The American Journal of Clinical Nutrition. Ag
osto de 1980; 33 (8): 1818-
1827. 13- Shekelle, R. B. et al. «Diet, serum cholesterol, and death from coronary disease: t
he Western Electric Study». The New England Journal of Medicine. 8 de enero de 1981;
304 (2): 65-
70. 14- Aro, A. et al. «Transfatty acids in dairy and meat products from 14 European countr
ies: the TRANSFAIR Study». Journal of Food Composition and Analysis. Junio de 1998;
11 (2): 150-160. DOI: 10.1006/jfca.1998.0570. Fecha de la consulta: 12 de abril de
2015. 15- Mensink, R. P. y Katan, M. B. «Effect of dietary trans fatty acids on high-
density and low-
density lipoprotein cholesterol levels in healthy subjects». The New En- gland Journal of M
edicine. 16 de agosto de 1990; 323 (7): 439-
445. 16- Mozaffarian, D. et al. «Trans fatty acids and cardiovascular disease». The New En
gland Journal of Medicine. 13 de abril de 2006; 354 (15): 1601-
1613. 17- Mente, A. et al. «A systematic review of the evidence supporting a causal link be
tween dietary factors and coronary heart disease». Archives of Internal Medicine.
13 de abril de 2009; 169 (7): 659-
669. 18- Hu, F. B. et al. «Dietary fat intake and the risk of coronary heart disease in women
». The New England Journal of Medicine. 20 de noviembre de 1997; 337 (21): 1491-
1499. 19- Leosdottir, M. et al. «Dietary fat intake and early mortality patterns: data from th
e Malmo Diet and Cancer Study». Journal of Internal Medicine. Agosto de 2005; 258 (2):
153-
165. 20- Chowdhury, R. et al. «Association of dietary, circulating, and supplement fatty aci
ds with coronary risk: a systematic review and meta-
analysis». Annals of Internal Medicine. 18 de marzo de 2014; 160 (6): 398-406. 21- Siri-
Tarino, P. W. et al. «Meta-
analysis of prospective cohort studies evaluating the association of saturated fat with cardio
vascular disease». The American Journal of Clinical Nutrition. Marzo de 2010; 91 (3): 535-
546. 22- Yamagishi, K. et al. «Dietary intake of saturated fatty acids and mortality from car
diovascular disease in Japanese». The American Journal of Clinical Nutrition. Publicado
por primera vez el 4 de agosto de 2010. DOI: 10.3945/ajcn.2009.29146. Fecha de la
2015. 23- Wakai, K. et al. «Dietary intakes of fat and total mortality among Japanese po- p
ulations with a low fat intake: the Japan Collaborative Cohort (JACC)
Study». Nutrition & Metabolism (Londres). 6 de marzo de 2014; 11 (1): 12. 24- Ascherio,
A. et al. «Dietary fat and risk of coronary heart disease in men: cohort follow up study in th
e United States». BMJ. 13 de julio de 1996; 313 (7049): 84-
90. 25- Gillman, M. W. et al. «Margarine intake and subsequent heart disease in men». Epi
demiology. Marzo de 1997; 8 (2): 144-
149. 26- Mozaffarian, D. et al. «Dietary fats, carbohydrate, and progression of coronary
atherosclerosis in postmenopausal women». The American Journal of Clinical Nutrition. N
oviembre de 2004; 80 (5): 1175-
1184. 27- Kagan, A. et al. «Dietary and other risk factors for stroke in Hawaiian Japanese
men». Stroke. Mayo-junio de 1985; 16 (3): 390-
396. 28- Gillman, M. W. et al. «Inverse association of dietary fat with development of ische
mic stroke in men». The Journal of the American Medical Association. 24-31 de diciembre
de 1997; 278 (24): 2145-
2150. 29- «National Cholesterol Education Program Expert Panel on Detection, Evalua- tio
n, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)».
National Institutes of Health; National Heart, Lung, and Blood Institute. Sep- tiembre de
2002. Puede leerse en www.nhlbi.nih.gov/files/docs/resources/heart/atp-3-cholesterol-full-
report.pdf. Fecha de la consulta: 12 de abril de
2015. 30- Kratz, M. et al. «The relationship between high-
fat dairy consumption and obesity, cardiovascular, and metabolic disease». European Jour
nal of Nutrition. Febrero de 2013; 52 (1): 1-
24. 31- Rosell, M. et al. «Association between dairy food consumption and weight change
over 9 y in 19,352 perimenopausal women». The American Journal of Clinical Nutrition. D
iciembre de 2006; 84 (6): 1481-1488. 32- Collier, G. y O’Dea, K. «The effect of co-
ingestion of fat on the glucose, insulin and gastric inhibitory polypeptide responses to carbo
hydrate and protein». The American Journal of Clinical Nutrition. Junio de 1983; 37 (6): 94
1-
944. 33- Willett, W. C. «Dietary fat plays a major role in obesity: no». Obesity Reviews. Ma
yo de 2002; 3 (2): 59-
68. 34- Howard, B. V. et al. «Low fat dietary pattern and risk of cardiovascular
disease». The Journal of the American Medical Association. 8 de febrero de 2006; 295 (6): 655-
666.
NOTAS 1- Knowler, W. C. et al. «10-year follow-

up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Stu
dy». The Lancet. 14 de noviembre de 2009; 374 (9702): 1677-
1686. 2- Leibel, R. L. y Hirsch, J. «Diminished energy requirements in reduced-
obese patients». Metabolism. Febrero de 1984; 33 (2): 164-
170. 3- Sacks, F. M. et al. «Comparison of weight-
loss diets with different compositions of fat, protein, and carbohydrates». The New England
Journal of Medicine. 26 de febrero de 2009; 360 (9): 859-
873. 4- Johnston, B. C. et al. «Comparison of weight loss among named diet programs in o
verweight and obese adults: a meta-
analysis». The Journal of the American Medi- cal Association. 3 de septiembre de 2014; 31
2 (9): 923-
933. 5- Grassi, D., Necozione, S., Lippi, C., Croce, G., Valeri, L., Pasqualetti, P., Desideri,
G., Blumberg, J. B. y Ferri, C. «Cocoa reduces blood pressure and insulin resistance and
improves endothelium-dependent vasodilation in
hypertensives». Hypertension. Agosto de 2005; 46 (2): 398-
405. 6- Grassi, D. et al. «Blood pressure is reduced and insulin sensitivity increased in gluc
ose-intolerant, hypertensive subjects after 15 days of consuming
highpol- yphenol dark chocolate». The Journal of Nutrition. Septiembre de 2008; 138 (9): 1
671-
1676. 7- Djousse, L. et al. «Chocolate consumption is inversely associated with prevalent c
oronary heart disease: the National Heart, Lung, and Blood Institute Family
Heart Study». Clinical Nutrition. Abril de 2011; 30 (2): 182-
187. DOI: 10.1016/ j.clnu.2010.08.005. Publicado en línea el 19 de septiembre de 2010.
Fecha de la consulta: 6 de abril de 2015.
8- Sabate, J. y Wien, M. «Nuts, blood lipids and cardiovascular disease». Asia Paci- fic Jou
rnal of Clinical Nutrition. 2010; 19 (1): 131-
136. 9- Jenkins, D. J. et al. «Possible benefit of nuts in type 2 diabetes». The Journal of Nut
rition. Septiembre de 2008; 138 (9): 1752S-1756S. 10- Hernández-
Alonso, P. et al. «Beneficial effect of pistachio consumption on glucose metabolism,
insulin resistance, inflammation, and related metabolic risk markers: a randomized
clinical trial». 14 de agosto de 2014. DOI: 10.2337/dc14-1431 [publicación en línea previa
a la publicación impresa]. Fecha de la consulta: 6 de abril de
2015. 11- Walton, A. G. «All sugared up: the best and worst breakfast cereals for kids». Fo
rbes [Internet]. 15 de mayo de 2014. Puede leerse en www.forbes.com/sites/alicegwalton/2
014/05/15/all-sugared-up-the-best-and-worst-breakfast-cereals-for-kids/. Fecha de la
2015. 12- Fernández, M. L. «Dietary cholesterol provided by eggs and plasma lipoprotein
s in healthy populations». Current Opinion in Clinical Nutrition & Metabolic Care. Enero
de 2006; 9 (1): 8-
12. 13- Mutungi, G. et al. «Eggs distinctly modulate plasma carotenoid and lipoprotein sub
classes in adult men following a carbohydrate-
restricted diet». The Journal of Nutritional Biochemistry. Abril de 2010; 21 (4): 261-
267. DOI: 10.1016/ j.jnutbio.2008.12.011. Publicado en línea el 14 de abril de
2009. 14- Shin, J. Y., Xun, P., Nakamura, Y. y He, K. «Egg consumption in relation to risk
of cardiovascular disease and diabetes: a systematic review and meta-
analysis». The American Journal of Clinical Nutrition. Julio de 2013; 98 (1): 146-
159. 15- Rong, Y. et al. «Egg consumption and risk of coronary heart disease and stroke: d
ose-response meta-analysis of prospective cohort studies». BMJ. 2013; 346:e8539.
DOI: 10.1136/bmj.e8539. Fecha de la consulta: 6 de abril de
2015. 16- Cordain, L. et al. «Influence of moderate chronic wine consumption on insulin se
nsitivity and other correlates of syndrome X in moderately obese
women». Metabolism. Noviembre de 2000; 49 (11): 1473-
1478. 17- Cordain, L. et al. «Influence of moderate daily wine consumption on body we- ig
ht regulation and metabolism in healthy free-
living males». Journal of the Ame- rican College of Nutrition. Abril de 1997; 16 (2): 134-
139. 18- Napoli, R. et al. «Red wine consumption improves insulin resistance but not endot
helial function in type 2 diabetic patients». Metabolism. Marzo de 2005; 54 (3): 306-
313. 19- Huxley, R. et al. «Coffee, decaffeinated coffee, and tea consumption in relation to
incident type 2 diabetes mellitus: a systematic review with meta-
analysis». Archi- ves of Internal Medicine. 14 de diciembre de 2009; 169 (22): 2053-
2063. 20- Gómez-
Ruiz, J. A., Leake, D. S. y Ames, J. M. «In vitro antioxidant activity of coffee compounds
and their metabolites». Journal of Agricultural and Food Chemistry. 22 de agosto de 2007;
55 (17): 6962-
6969. 21- Milder, I. E., Arts, I., Cvan de Putte, B., Venema, D. P. y Hollman, P. C. «Lignan
contents of Dutch plant foods: a database including lariciresinol,
pinoresinol, secoisolariciresinol and metairesinol». British Journal of Nutrition. Marzo de 2
005; 93 (3): 393-
402. 22- Clifford, M. N. «Chlorogenic acids and other cinnamates: nature, occurrence and d
ietary burden». Journal of the Science of Food and Agriculture. 1999; 79 (5): 362- 372. 23-
Huxley, R. et al. «Coffee, decaffeinated coffee, and tea consumption in relation to incident
type 2 diabetes mellitus: a systematic review with meta-analysis».
Archives of Internal Medicine. 14 de diciembre de 2009; 169 (22): 2053-
2063. 24- Van Dieren, S. et al. «Coffee and tea consumption and risk of type 2 diabetes». D
iabetologia. Diciembre de 2009; 52 (12): 2561-
2569. 25- Odegaard, A. O. et al. «Coffee, tea, and incident type 2 diabetes: the Singapore C
hinese Health Study». The American Journal of Clinical Nutrition. Octubre de 2008; 88
(4): 979-
985. 26- Freedman, N. D., Park, Y., Abnet, C. C., Hollenbeck, A. R. y Sinha, R. «Asso- cia
tion of coffee drinking with total and cause-
specific mortality». The New England Journal of Medicine. 17 de mayo de 2012; 366 (20):
1891-1904. 27- López-García, E., van Dam, R. M., Li, T. Y., Rodríguez-
Artalejo, F. y Hu, F. B. «The relationship of coffee consumption with mortality». Annals of
Internal Medicine. 17 de junio de 2008; 148 (2): 904-
914. 28- Eskelinen, M. H. y Kivipelto, M. «Caffeine as a protective factor in dementia and
Alzheimer’s disease». Journal of Alzheimer’s Disease. 2010; 20 supl. 1: 167-
174. 29- Santos, C. et al. «Caffeine intake and dementia: systematic review and meta- analy
sis». Journal of Alzheimer’s Disease. 2010; 20 supl. 1: S187-204. DOI: 10.3233/ JAD-
2010-091387. Fecha de la consulta: 6 de abril de 2015. 30- Hernan, M. A. et al. «A meta-
analysis of coffee drinking, cigarette smoking, and the risk of Parkinson’s disease». Annals
of Neurology. Septiembre de 2002; 52 (3): 276-
284. 31- Ross, G. W. et al. «Association of coffee and caffeine intake with the risk of Pa- r
kinson disease». The Journal of the American Medical Association. Mayo de 2000; 283
(20): 2674-
2679. 32- Klatsky, A. L. et al. «Coffee, cirrhosis, and transaminase enzymes». Archives of I
nternal Medicine. 12 de junio de 2006; 166 (11): 1190-1195.
33- Larrson, S. C. y Wolk, A. «Coffee consumption and risk of liver cancer: a meta- analysi
s». Gastroenterology. Mayo de 2007; 132 (5): 1740-
1745. 34- Kobayashi, Y., Suzuki, M. y Satsu, H. et al. «Green tea polyphenols inhibit the s
odiumdependent glucose transporter of intestinal epithelial cells by a
competitive mechanism». Journal of Agricultural and Food Chemistry. Noviembre de 2000
; 48 (11): 5618-
5623. 35- Crespy, V. y Williamson, G. A. «A review of the health effects of green tea cate-
chins in in vivo animal models». The Journal of Nutrition. Diciembre de 2004; 134 (12
supl.): 3431S-
3440S. 36- Cabrera, C. et al. «Beneficial effects of green tea: a review». Journal of the Ame
- rican College of Nutrition. Abril de 2006; 25 (2): 79-99. 37- Hursel, R. y Westerterp-
Plantenga, M. S. «Catechin-and caffeine-
rich teas for control of body weight in humans». The American Journal of Clinical Nutritio
n. Di- ciembre de 2013; 98 (6): 1682S-
1693S. 38- Dulloo, A. G. et al. «Green tea and thermogenesis: interactions between cate- c
hinpolyphenols, caffeine and sympathetic activity». International Journal of Obesity. Febre
ro de 2000; 24 (2): 252-
258. 39- Venables, M. C. et al. «Green tea extract ingestion, fat oxidation, and glucose toler
ance in healthy humans». The American Journal of Clinical Nutrition. Marzo de 2008; 87
(3): 778-
784. 40- Dulloo, A. G. et al. «Efficacy of a green tea extract rich in catechin polyphenols an
d caffeine in increasing 24-h energy expenditure and fat oxidation in
humans». The American Journal of Clinical Nutrition. Diciembre de 1999; 70 (6): 1040-
1045. 41- Koo, M. W. L. y Cho, C. H. «Pharmacological effects of green tea on the gastro
intestinal system». European Journal of Pharmacology. 1 de octubre de 2004; 500
(1-3): 177-185. 42- Hursel, R., Viechtbauer, W. y Westerterp-
Plantenga, M. S. «The effects of green tea on weight loss and weight maintenance: a meta-
analysis». International Journal of Obesity (Londres). Septiembre de 2009; 33 (9): 956-
961. DOI: 10.1038/ ijo.2009.135. Publicado en línea el 14 de julio de 2009. Fecha de la
2015. 43- Van Dieren, S. et al. «Coffee and tea consumption and risk of type 2 diabetes». D
iabetologia. Diciembre de 2009; 52 (12): 2561-
2569. 44- Odegaard, A. O. et al. «Coffee, tea, and incident type 2 diabetes: the Singapore C
hinese Health Study». The American Journal of Clinical Nutrition. Octubre de 2008; 88
(4): 979-985. 45- Patrick, L. y Uzick, M. «Cardiovascular disease: C-
reactive protein and the in- flammatory disease paradigm: HMG-CoA reductase inhibitors,
alpha-
tocopherol, red yeast rice, and olive oil polyphenols. A review of the literature». Alternative
Medicine Review. Junio de 2001; 6 (3): 248-
271. 46- Aviram, M. y Eias, K. «Dietary olive oil reduces low-
density lipoprotein uptake by macrophages and decreases the susceptibility of the
lipoprotein to
undergo lipid peroxidation». Annals of Nutrition and Metabolism. 1993; 37 (2): 75-
84. 47- Smith, R. D. et al. «Long-
term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects
». British Journal of Nutrition. Septiembre de 2003; 90 (3): 597-
606. 48- Ferrara, L. A. et al. «Olive oil and reduced need for antihypertensive medica- tions
». Archives of Internal Medicine. 27 de marzo de 2000; 160 (6): 837-842. 49- Martínez-
González, M. A. et al. «Olive oil consumption and risk of CHD and/ or stroke: a meta-
analysis of case-control, cohort and intervention studies». British
Journal of Nutrition. Julio de 2014; 112 (2): 248-
259. 50- Chen, M., Pan, A., Malik, V. S. y Hu, F. B. «Effects of dairy intake on body weight and f
at: a meta-
analysis of randomized controlled trials». The American Journal of Clinical Nutrition. Octubre de 2
012; 96 (4): 735-747. 51- Mozaffarian, D. et al. «Trans-
palmitoleic acid, metabolic risk factors, and new- onset diabetes in U.S. adults: a cohort study». Ann
als of Internal Medicine. 21 de diciembre de 2010; 153 (12): 790-
799. 52- Hyman, M. «The super fiber that controls your appetite and blood sugar». The Huffington
Post [Internet]. 29 de mayo de 2010 (actualizado el 11 de noviembre de 2013). Puede leerse
en www.huffingtonpost.com/dr-mark-hyman/fiber-health-the-super-fi_b_594153.html. Fecha de la
2015. 53- Sugiyama, M. et al. «Glycemic index of single and mixed meal foods among common Ja
panese foods with white rice as a reference food». European Journal of Clinical Nutrition. Junio de
2003; 57 (6): 743-752. DOI: 10.1038/sj.ejcn.1601606. Fecha de la consulta: 6 de abril de 2015.
NOTAS 1- Arbesmann, R. «Fasting and prophecy in pagan and Christian antiquity». Tradi
tio. 1951; 7: 1-
71. 2- Lamine, F. et al. «Food intake and high density lipoprotein cholesterol levels change
s during Ramadan fasting in healthy young subjects». Tunis Med. Octubre de 2006; 84
(10): 647-
650. 3- Felig, P. «Starvation». En: DeGrot, L. J., Cahill, G. F. Jr. et al., editores. Endocri- n
ology (vol 3). Nueva York (EUA): Grune & Stratton, 1979, pp. 1927-
1940. 4- Coffee, C. J. Quick look: metabolism. Hayes Barton Press, 2004, p. 169. 5- Owen,
O. E. y Felig, P. «Liver and kidney metabolism during prolonged starvation». The Journal
of Clinical Investigation. Marzo de 1969; 48: 574-
583. 6- Merrimee, T. J. y Tyson, J. E. «Stabilization of plasma glucose during fasting: norm
al variation in two separate studies». The New England Journal of Medicine. 12 de
diciembre de 1974; 291 (24): 1275-1278. 7- Heilbronn, L. K. «Alternate-
day fasting in nonobese subjects: effects on body weight, body composition, and energy
metabolism». The American Journal of Clinical Nutrition. 2005; 81: 69-
73. 8- Halberg, N. «Effect of intermittent fasting and refeeding on insulin action in healthy
men». Journal of Applied Physiology. Diciembre de 1985; 99 (6): 2128-
2136. 9- Rudman, D. et al. «Effects of human growth hormone in men over 60 years old».
The New England Journal of Medicine. 5 de julio de 1990; 323 (1): 1-
6. 10- Ho, K. Y. et al. «Fasting enhances growth hormone secretion and amplifies the comp
lex rhythms of growth hormone secretion in man». The Journal of Clinical Investigation. A
bril de 1988; 81 (4): 968-
975. 11- Drenick, E. J. «The effects of acute and prolonged fasting and refeeding on
water, electrolyte, and acid-base metabolism». En: Maxwell, M. H. y Kleeman,
C. R., editores. Clinical disorders of fluid and electrolyte metabolism. 3.ª ed. Nueva York (
EUA): McGraw-Hill,
1979. 12- Kerndt, P. R. et al. «Fasting: the history, pathophysiology and complications». W
estern Journal of Medicine. Noviembre de 1982; 137 (5): 379-
days’ duration». Postgraduate Medical Journal. Marzo de 1973; 49 (569): 203-
209. 14- Lennox, W. G. «Increase of uric acid in the blood during prolonged starvation». T
he Journal of the American Medical Association. 23 de febrero de 1924; 82 (8): 602- 604. 1
5- Drenick, E. J. et al. «Prolonged starvation as treatment for severe obesity». The Journal
of the American Medical Association. 11 de enero de 1964; 187: 100-
105. 16- Felig, P. «Starvation». En: DeGroot, L. J. y Cahill, G. F. Jr. et al., editores. Endo-
crinology (vol 3). Nueva York (EUA): Grune & Stratton, 1979, pp. 1927-
40. 17- Bhutani, S. et al. «Improvements in coronary heart disease risk indicators by alterna
te-day fasting involve adipose tissue modulations». Obesity. Noviembre de 2010; 18 (11):
2152-
2159. 18- Stote, K. S. et al. «A controlled trial of reduced meal frequency without caloric re
striction in healthy, normal-weight, middle-
aged adults». The American Journal of Clinical Nutrition. Abril de 2007; 85 (4): 981-
988. 19- Heilbronn, L. K. «Alternate-
day fasting in nonobese subjects: effects on body weight, body composition, and energy me
tabolism». The American Journal of Cli- nical Nutrition. 2005; 81: 69-
73. 20- Zauner, C. «Resting energy expenditure in short-
term starvation is increased as a result of an increase in serum norepinephrine». The Americ
an Journal of Clinical
Nutrition. Junio de 2000; 71 (6): 1511-
1515. 21- Stubbs, R. J. et al. «Effect of an acute fast on energy compensation and feeding b
ehaviour in lean men and women». International Journal of Obesity. Diciembre de 2002;
26 (12): 1623-
1628. 22- Duncan, G. G. «Intermittent fasts in the correction and control of intractable obes
ity». Transactions of the American Clinical and Climatological Association. 1963; 74: 121-
129. 23- Duncan, D. G. et al. «Correction and control of intractable obesity. Practical applic
ation of Intermittent Periods of Total Fasting». The Journal of the American Medical Assoc
iation. 1962; 181 (4): 309-
312. 24- Drenick, E. «Prolonged starvation as treatment for severe obesity». The Journal of
the American Medical Association. 11 de enero de 1964; 187: 100-
105. 25- Thomson, T. J. et al. «Treatment of obesity by total fasting for up to 249 days». Th
e Lancet. 5 de noviembre de 1966; 2 (7471): 992-
996. 26- Kerndt, P. R. et al. «Fasting: the history, pathophysiology and complications». We
stern Journal of Medicine. Noviembre de 1982; 137 (5): 379-
399. 27- Folin, O. y Denis, W. «On starvation and obesity, with special reference to aci- do
sis». The Journal of Biological Chemistry. 1915; 21: 183-
192. 28- Bloom, W. L. «Fasting as an introduction to the treatment of obesity». Metabolism
. Mayo de 1959; 8 (3): 214-
days’ duration». Postgraduate Medical Journal. Marzo de 1973; 49 (569): 203-
209. 30- Merimee, T. J. y Tyson, J. E. «Stabilization of plasma glucose during fasting: Nor
mal variation in two separate studies». The New England Journal of Medicine. 12 de
diciembre de 1974; 291 (24): 1275-1278.
31- Bloom, W. L. «Fasting ketosis in obese men and women». The Journal of Labo- ratory
and Clinical Medicine. Abril de 1962; 59: 605-
612. 32- Forbes, G. B. «Weight loss during fasting: implications for the obese». The Americ
an Journal of Clinical Nutrition. Septiembre de 1970; 23: 1212-
1219. 33- Harvie, M. N. et al. «The effects of intermittent or continuous energy restriction
on weight loss and metabolic disease risk markers». International Journal of Obesity (Lond
res). Mayo de 2011; 35 (5): 714-
727. 34- Klempel, M. C. et al. «Intermittent fasting combined with calorie restriction is effe
ctive for weight loss and cardio-protection in obese women». Nutrition Journal. 2012; 11:
98. DOI: 10.1186/1475-2891-11-98. Fecha de la consulta: 8 de abril de
2015. 35- Williams, K. V. et al. «The effect of short periods of caloric restriction on weight
loss and glycemic control in type 2 diabetes». Diabetes Care. Enero de 1998; 21 (1): 2-
8. 36- Koopman, K. E. et al. «Hypercaloric diets with increased meal frequency, but not
meal size, increase intrahepatic triglycerides: A randomized controlled
trial». Hepatology. Agosto de 2014; 60 (2): 545-
555. 37- Yanovski, J. A., Yanovski, S. Z., Sovik, K. N., Nguyen, T. T., O’Neil, P. M. y Se-
bring, N. G. «A prospective study of holiday weight gain». The New England Journal of M
edicine. 23 de marzo de 2000; 342 (12): 861-867.
NOTAS 1- Hiebowicz, J. et al. «Effect of cinnamon on post prandial blood glucose, gastric emptyi
ng and satiety in healthy subjects». The American Journal of Clinical Nutrition. Junio de 2007; 85
(6): 1552-
1556. 2- Greenberg, J. A. y Geliebter, A. «Coffee, hunger, and peptide YY». Journal of the Americ
an College of Nutrition. Junio de 2012; 31 (3): 160-166.

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NOTAS 1- Wright, J. D., Kennedy-

NOTAS 1- Owen, O. E. y Cahill, G. F. Jr. «Metabolic effects of exogenous glucocorticoid

NOTAS 1- Pennington, A. W. «A reorientation on obesity». The New England Journal of

NOTAS 1- Center for Science in the Public Interest [Internet]. «Non-

NOTAS *- El equivalente a 6º de primaria y 1º y 2º de ESO (N. del T.). 1- Foster, G. D. et

NOTAS 1- Friedman, et al. «Comparative effects of low-carbohydrate high-

NOTAS 1- Knowler, W. C. et al. «10-year follow-

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