STUDY GUIDE N 4

Steiner holistic approach on the detoxification I.- Escoja la alternativa correcta 1. La propuesta de steiner para mejorar la salud incluye los siguientes tpicos a) Desintoxicacin, ejercicios y alimentacin b) Desintoxicacin, ejercicios y nutricin c) Desintoxicacin, ejercicios y dieta d) Todas las anteriores 2.- Una de las principales herramientas de educacin y por tanto de preparacin para el cliente sobre el barco es: a) b) c) d) Los seminarios y charlas Las clases de spinning La evaluacin del estado fsico Clases de baile entretenido

3.- Uno de los principales riesgos del consumo de asparthame es a) b) c) d) Es un producto carcinognico Es un gran endulzante pero produce diabetes No est aprobado por el FDA Ninguna de las anteriores

4.- Con respecto al endulzante splenda, las personas debieran saber que: a) Es natural y por lo tanto no precisa de conservantes b) Es artificial y suprime a las bacterias benficas del tracto digestivo, interfiriendo en la correcta asimilacin celular de nutrientes c) Es similar al asparthame pero mejor que la azcar blanca d) Ninguna de las anteriores 5.- Las toxinas pueden causar diversas enfermedades crnicas en nuestro cuerpo por acumulacin, una definicin correcta de toxinas sera: a) Son productos de desecho (catabolitos secundarios) b) Son diversos tipos de venenos (metales pesados: mercurio, plomo, amalgamas) c) Son diversos tipos de sustancias que pueden encontrarse fuera y dentro del cuerpo humano, provocando diversos tipos de enfermedades crnicas. Estos productos pueden ser orgnicos o inorgnicos y varan en su grado de toxicidad. d) All previous 6.- The four ways in which toxins enter our bodies are: a) b) c) d) Digestion, inhalation, absortion, reaction Digestion, contact, dietary, reaction Absortion, inhalation, contact, food Ninguna de las anteriores

II.- Connect the organ with symptoms that correspond Colon Liver and gallbladder Lungs Kidney and bladder Lymph Blood and skin
- Skin Problems - Poor Complexion - Lack of Vigour Hyperactivity - Difficult or Frequent Urination - Lower Back Pain - Weak Joints - Cold to Touch - Easily Fatigues - Headaches, including migraines Insomnia - Food Sensitivities - Frequent Colds & Infections - Tiredness - Lethargic Body Tender Lymph Nodes - Constipation - Mental Dullness - Tired for no Reason - Bad Breath - Shortness of Breath - Coughing - Cold Hands - Congestion

III. - Preguntas de desarrollo a) Resume las funciones del hgado en seis lneas b) De qu forma procesa el hgado las grasas? Explica el mecanismo de formacin de los clculos biliares c) Explica tres de las funciones del sistema linftico d) Si el sistema linftico, a diferencia del circulatorio, no posee un corazn para impulsar su flujo, de qu manera circula por el cuerpo? e) Como afecta la flora intestinal a la salud integral del cuerpo? f) Cunta agua es necesario ingerir a diario y como afecta al colon la cantidad de humedad? g) Cmo se conecta el sistema circulatorio con el linftico?

R EAD THE FOLLOWING TEXT AND ANSWER THE QUESTIONS BELLOW How to eliminate 50 percent of all coronary events
By Dr. Barry Sears, founders of zone diet

The European Society of Cardiology estimates a 50 percent reduction of coronary events if you can stabilize soft, vulnerable plaques (1). We are often led to believe that plaques you can see on an angiogram are killer plaques. Its true that if they are large enough to obstruct blood flow, they will decrease oxygen transfer to the heart muscle cells making them more tired with less effort. This is the definition of stable angina. It simply means it takes less effort to overexert the heart muscles before they fatigue. However, you need approximately a 90 percent total obstruction of the blood vessel to develop stable angina. These plaques account for most of the plaques you might find in an angiogram. This is why if you take an angiogram, you are often immediately wheeled into the operating room to have a stent put into the artery with the belief you are only seconds away from an immediate heart attack and death. However, the same angiogram cant see a few plaques (because they are so small), known as the soft, vulnerable ones. When soft, vulnerable plaques rupture (like a pimple), then you have the death and disability (i.e., damaged heart tissue) that truly characterize heart disease. Technically, this is called an acute coronary event, and it has very little to do with the stable plaques that can cause angina. It is this small number of rogue soft, vulnerable plaques that are the true killers in heart disease (2,3). The ultimate cause of plaque rupture is cellular inflammation inside the plaque. Cellular inflammation degrades the fibrous external coating of the plaque. Usually inside these soft, vulnerable plaques are also a lot of macrophages engorged with lipids. This is called the necrotic core. When the plaque bursts, these lipid pools are released into the bloodstream causing platelet aggregation and the rapid blockage of the artery resulting in a complete restriction of blood flow (as opposed to a limited restriction of blood flow with a typical stable plaque that will never rupture). It is estimated that about 75 percent of all coronary events are caused by ruptures of the soft, vulnerable plaques (2). As I mentioned above, the really scary part of this story is that there is no type of imaging technology that can detect dangerous soft, vulnerable plaques. In essence, you dont know if you have them or not. This is why the prediction of impeding cardiovascular events remains a guessing game. Even more interesting is that these soft, vulnerable plaques seem to form rather quickly (in about 10 years) as opposed to growing slowly over a lifetime (4). Moreover, the rate of growth of these soft, vulnerable plaques is strongly correlated with increasing insulin levels in the blood (4). So what does this mean for people who dont want to die from a sudden rupture of soft, vulnerable plaques that cant be detected? The first thing is to reduce the inflammation within the plaque. Surprisingly, there is only one clinical study that has ever been published that addressed this question, and it used fish oil (5). This study indicated that if you give patients relatively high doses of fish oil, you could

see a definite remodeling of the soft, vulnerable plaques in about 40 days compared to subjects taking a placebo composed of safflower oil. The plaques in the subjects taking the fish oil became less inflamed, had higher levels of omega-3 fatty acids, fewer macrophages and more well-formed fibrous caps compared to those taking the placebo. So taking a therapeutic level of fish oil for a lifetime seems to be a good way to reduce the rupture of these plaques. Another way to potentially reduce their formation in the first place is lower insulin levels. The reason insulin levels are elevated is because organs, such as the adipose tissue, the liver and the muscles, are also inflamed (6). The best way to reduce that systemic inflammation is to follow the anti-inflammatory diet and take therapeutic levels of fish oil for a lifetime. Your success is best measured by the AA/EPA ratio in the blood. Call me crazy, but I think thats what I have been recommending for the past 16 years (7).
References

Yia-Herttulala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Merrmann J, Hoefer IM, Juekma JW, Krams R, Kwak BR, Marx N, Maruszeqica M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C, and Tokgozoglu L. Stabilization of atherosclerotic plaques. Thomobosis and Haemostasis 106: 1-19 (2011) Schaar JA, Muller JE, Falk E, Virmani R, Fuster V, Serruys PW, Colombo A, Stefanadis C, Ward Casscells S, Moreno PR, Maseri A, and van der Steen AF. Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque. Eur Heart J 25: 1077-1082 (2004) Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J, Mozaffarian D, Nichol G, ODonnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S, Wong N, Wylie-Rosett J, and Hong Y. Heart disease and stroke statistics2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119:480-486 (2009) Hagg S, Salehpour M, Noori P, Lundstrom J, Possnert G, Takolander R, Konrad P, Rosfors S, Ruusalepp A, Skogsberg J, Tegner J, and Bjorkegren J. Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin. PLoS One 6: e1824 (2011) Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallagher PJ, Calder PC, and Grimble RF. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomized controlled trial. Lancet 2003 361: 477-485 (2003) Sears, B. Toxic Fat. Thomas Nelson. Nashville, TN (2008) Sears B. The Zone. Regan Books. New York, NY (1995) Nothing contained in this blog is intended to be instructional for medial diagnosis or treatment. If you have a medical concern or issue, please consult your personal physician immediately.

Questions a) What is the definition of angina? b) How you can control de coronary events? c) How inflammatory processes affecting the liver and other tissues acids in coronary events? d) How could we develop a diet-inflammatory? Prepare a Little presentation about the following text of Dr. Sears Changing gene expression

I have often stated that the real power of the Zone Diet is to change gene expression, especially the expression of anti-inflammatory genes. What I never realized is how rapid gene expression could occur. Now, new research from Norway gives me the answer (1). It takes about 24 hours! This pilot study is on the effect of diet on gene expression in healthy obese individuals. Interestingly, when the researchers calculated the estimated daily calorie requirements for these subjects necessary to maintain their weight, they were surprised that they were already eating 250 fewer calories per day than predicted to maintain their current weight. So much for the fact that obese individuals are fat because they eat more calories than they need to maintain their weight. In fact, this observation was confirmed in an earlier study in which the number of calories consumed by obese and lean individuals did not vary, but the obese individuals consumed fewer meals consisting of larger servings (2). So what the Norwegian researchers did was simply maintain the same number of calories the subjects were already eating and change the macronutrient balance to be very close to the Zone Diet (30 percent carbohydrates, 30 percent protein, and 40 percent fat). Then the subjects consumed six meals containing about 460 calories evenly spaced throughout the day so that the total calories consumed at any one time was moderate. Just making those two simple dietary changes resulted in more than an eight-pound weight loss in 28 days. The levels of body fat didnt change since the number of calories consumed was exactly the same as they were previously consuming. However, it appears that evenly spacing the meals and reducing the calorie size of the meals resulted in less insulin production and therefore less retained water. Then they looked to see if they could find any changes in gene expression in both the fat cells and the blood with the dietary changes. Amazingly they found dramatic changes in only 24 hours. Of the 16,000 genes they could identify, about 60 percent remained unchanged in their expression, but 40 percent were either turned on (i.e., up-regulated) or turned down (i.e., down-regulated). Interestingly, the changes seen in the first 24 hours were held constant throughout the 28 days of the experiment. Upon further analysis, the up-regulated genes corresponded to those that had antiinflammatory properties, and the down-regulated genes were those associated with chronic disease conditions, such as diabetes and heart disease. Furthermore, since these changes in gene expression occurred within 24 hours of the dietary change, they could not be attributed to any change in body weight and fat loss.

Fortunately, I had the opportunity to have dinner with the lead author of the study to discuss her work while I was in Europe last week. She told me that she has expanded the number of subjects in several new trials, and the results remain the same. I also found out that she has been following my work for many years. This type of study only confirms the power of genetic analysis to demonstrate how a highly structured diet with the correct macronutrient content can rapidly alter genetic expression and hence controls your future health. But the door swings both ways. An unbalanced diet will have just the opposite genetic effects. While I have always been impressed by the power of the Zone Diet, this new experimental data takes my respect for the Zone Diet to a new level of awe, even by me. References Brattbakk H-R, Arbo I, Aagaard S, Lindseth I, de Soysa AK, Langaas M, Kulseng B, Lindberg, and Johansen B. Balanced caloric macronutrient composition down regulates immunological gene expression in human blood cells-adipose tissue diverges. OMICS 15: doi:1089/omi.2010.0124 (2011) Berg C, Lappas G, Wolk A, Strandhagen E, Toren K, Rosengren A, Rosengren A, Thelle D, and Lissner L. Eating patterns and portion size associated with obesity in a Swedish population. Appetite 52: 21-26 (2009)