Rev Hematol Mex 2011;12(4):276-286

Artculo de revisin
Utilidad teraputica potencial de las clulas madre de la membrana
amnitica
Carmen L Insausti,* Miguel Blanquer,* Mara J Majado,* Alfredo Insausti,** Jos M Moraleda*,***

RESUMEN
Desde los primeros estudios de clulas madre obtenidas de la membrana amnitica se ha avanzado mucho en el conocimiento de las
caractersticas de estas clulas, sus mtodos de obtencin y procesamiento, as como de su potencialidad. Numerosos ensayos preclnicos
sugieren que las clulas madre de la membrana amnitica podran ser tiles en la regeneracin de una serie de alteraciones tisulares.
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estrecha colaboracin entre la investigacin bsica y los clnicos para que la terapia con clulas se haga realidad en la prctica diaria.
Palabras clave: membrana amnitica, clulas madre, clulas de la membrana amnitica, clulas epiteliales, clulas mesenquimales,
terapia celular.

ABSTRACT
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handling methods and potential of these cells. A lot of preclinical evidence suggests that human amniotic derived cells may be useful for
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of amniotic derived cells are due to differentiation of the transplanted cells themselves or to paracrine actions on the surrounding host tissue
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clinical reality, it is fundamental a close collaboration between basic scientists and clinicians.
Key words: Amnion, amniotic membrane, stem cell, amniotic epithelial stem cell, amniotic mesenchymal stem cell, Cell therapy.

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*
**
***

Servicio de Hematologa y Hemoterapia. Unidad de Terapia

Celular. Hospital Universitario Virgen de la Arrixaca.
Servicio de Oftalmologa. Hospital Universitario La Paz, Madrid.
Universidad de Murcia. Murcia, Madrid.

Correspondencia: Dra. Carmen L Insausti. Servicio de Hematologa

y Hemoterapia, Unidad de Terapia Celular. Hospital Universitario
Virgen de la Arrixaca. Ctra. Madrid-Cartagena. El Palmar 30120,
Murcia. Correo electrnico: caymed@gmail.com
Recibido: octubre 2011. Aceptado: noviembre 2011.
Este artculo debe citarse como: Insausti CL, Blanquer M, Majado
MJ, Insausti A, Moraleda JM. Utilidad teraputica potencial de
las clulas madre de la membrana amnitica. Rev Hematol Mex
2011;12(4):276-286.

276

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Referencias

Supervivencia celular. Sntesis y secrecin de catecolaminas y factores

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Supervivencia celular. Expresin de marcadores neuronales. Disminucin
del rea infartada. Mejora clnica
Integracin en tejido heptico. Expresin de marcadores hepticos.
Integracin heptica. Expresin de receptores.
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Localizacin en la regin supra-limbal, regin supra-espiral en la scala
vestibuli y en la regin subcentral del ligamento espiral en la scala timpani.
Supervivencia durante 3 semanas. Expresin de marcadores.
Integracin celular. Mejora de cicatrizacin. Reduccin de la incidencia
y tamao de hernias incisionales.
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Revista de Hematologa Volumen 12, nm. 4, octubre-diciembre 2011

Utilidad teraputica potencial de las clulas madre de la membrana amnitica

Cuadro 2. Publicaciones recientes acerca de la indicacin clnica de la membrana amnitica

Aos

Ttulos

Referencias

2000

Reconstitution of damaged corneas by transplantation of autologous limbal epithelial cells

62

2001

Amniotic membrane graft in ocular surface disease. Prospective study with 31 cases.

68

2003

Successful reconstruction of damaged ocular outer surface in humans using limbal and conjuctival stem cell
culture methods.

69

2004

The Amniotic membrane in ophthalmology

55

2005

Amniotic membrane use in ophthalmology

Amniotic membrane transplantation for ocular surface reconstruction.

56
64

2006

Ultrastructural analysis of in vivo expanded corneal epithelium on amniotic membrane

Amniotic membrane transplantation for treatment of symblepharon in a patient with recessive dystrophic epidermolysis bullosa.
Amniotic Membrane transplantation in palliative treatment of bullous keratopathy
Clinical outcome of autologous cultivated limbal epithelium transplantation

65
63

Amniotic Membrane Transplantation

Use of amniotic membrane graft and corneal transplantation in a patient with bilateral keratomalacia induced
by uncontrolled phenylketonuria
Use of amniotic membrane transplantation in the treatment of venous leg ulcers.
Amnia for intractable skin ulcers with recessive dystrophic epidermolysis bullosa: report of three cases.

57
60

2008

Amniotic membrane transplantation for the management of corneal epithelial defects: an in vivo confocal microscopic study.

66

2009

Manufacturing of human placenta-derived mesenchymal stem cells for clinical trials

75

2010

Amniotic membrane transplantation in the treatment of persistent epithelial defect on the corneal graft.
Use of amniotic membrane transplantation in isolated conjunctival Bowen disease: a case report
Dried irradiated human amniotic membrane as a biological dressing for facial burns--a 7-year case series
Amniotic membrane induces epithelialization in massive posttraumatic wounds.

67
61
73
74

2007

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Revista de Hematologa Volumen 12, nm. 4, octubre-diciembre 2011

283

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Revista de Hematologa Volumen 12, nm. 4, octubre-diciembre 2011