Farmacologa

2012-2013

CASO 1: Activadores de Sistema Renina Angiotensina Aldosterona

A 72-year-old man presents to the office for routine follow-up. He is under treatment for hypertension
and congestive heart failure with enalapril and a diuretic. His blood pressure is under acceptable
control and he has no symptoms of heart failure at present. He does complain that he has been
coughing frequently in the past few months. History and examination reveal no other cause of a chronic
cough, so you decide to discontinue his enalapril and start him on losartan.

1. Cul es el mecanismo de accin del enalapril?













2. Mediante qu mecanismo el enalapril se convierte en su forma activa en enalaprilato?














3. Cul es la posible causa de la tos?

















Universidad de Montemorelos/Facultad de Ciencias de la Salud/Carrera de Medicina

47

2012-2013

Farmacologa

4.


















5.















6.

7.

8.

Cul es el mecanismo de accin del losartn?

Defina Hipertensin de acuerdo al reporte de la Joint National Committee on Detection, Evaluation,

and Treatment of High Blood Pressure.

Losartn acta disminuyendo cul de los siguientes?

A. Activa el receptor AT-1
B. Produccin de Bradiquinina
C. Produccin de angiotensina
D. Produccin de renina

Cul de los siguientes es un efecto adverso limitado de los inhibidores de la ACE? Which of the
following is a limiting adverse effect of ACE inhibitors?
A. Acidosis
B. Hipercalemia
C. Hipernatremia
D. Hipocalemia
E. Hiponatremia

Which of the following is an advantage of losartan over enalapril?
A. Better efficacy in lower blood pressure
B. Better prevention of secondary myocardial events
C. Less cost
D. Less incidence of angioedema
Universidad de Montemorelos/Facultad de Ciencias de la Salud/Carrera de Medicina