ORIGINAL ARTICLES 509

Los autores describen el equipo empleado oral o per un tubo polyethylenic a in Ic

con el aparato de cintilaci#{243}n. El I 131 fue stomacho, variava in 65 casos ab 10 a 60 pro
bien tolerado y no caus#{243}v#{243}mitos en esta serie, cento. In 2 casos con un sorption de minus que
tanto cuando se emple#{243} la via oral como Ia 10 pro cento e in 3 casos con un sorption vicin
sonda de polietileno introducida al est#{243}mago. a 60 pro cento, le valores obtenite se explica
Discuten Ia actividad tiroidea en prematuros possibilemente per rationes technic o le uso
y niflos nacidos a t#{233}rmino, segin los datos surrepticie de extracto thyroide per Ic matre.
obtenidos por el aprovechamiento del I 131, Le distribution del valores de sorption de
24 horas despu#{233}s de su administraci#{243}n; ade- 1-131 obtenite in iste serie es intra le limites del
lantan la idea de que en ellos funciona la norma registrate in studios con pueros e pueras
gl#{225}ndula en forma similar a ni#{241}osmayores. de plus alte etates e con adultos per medio del
contator Geiger-Mueller.
INTERLINGUA ABSTRACT Le differentias del valores obtenite in Ic
presente studio per medio de (1) he contator
Un Studio del Sorption de lodo (1-131)
Geiger-Mueller e (2) Ic contator a scintillation
per le Thyroide de Infantes Prematur esseva minus que 5 pro cento si tosto que
Es describite Un methodo pro determinar le nostre experientia con le apparatura habeva
sorption de 1-131 24 horas post le administra- maturate.
tion de 5 tc a infantes prematur per via oral si Le apparatura usate in cOIlIlexiOn con Ic
possibile o per un catheter polyethylenic si contator a scintillation es
describite. 1-131 ad-
necesse. Le instrumentario includeva un con- ministrate oralmente e per tubo polyethylenic
tator Geiger-Mueller e un contator a scintilla- a in Ic stomacho es ben tolerate. In Ic presente
tion de construction special. Iste ultime es serie illo causava nulle vomito.
describite in detalio. Es discutite Ic activitate del glandula thy-
In un serie de 65 infantes prematur coil roide in infantes prematur e in infantes nascite
pesos ab 991 g a 2481 g e cinque infantes a termino in tanto que illo se manifesta in Ic
nascite a termino con pesos ab 2522 g a 2694 sorption de 1-131 24 horas post le administra-
g, a etates de inter 1 e 63 dies, le sorption de tion. Es presentate datos que indica que in tal
1-131 per le thyroide, mesurate per le contator illdividuOs Ic glandula thyroide functiona in un
Geiger-Mueller e le contator a scintillation 24 maniera simile al maniera de su functionamento
horas post le administration de 5 &c per via in infantes e juveniles de etates plus avantiate.

COMBINED ANTIBIOTIC THERAPY FOR THE SUPPRESSION OF RESISTANT VARIANTS IN

URINARY INFECTION, H. Stern and S. D. Elek. (Brit. M. J., 4951:1304, November
26, 1955.)
The use of pairs of antibiotics to suppress the emergence of resistant strains has
been the subject of several investigations and has been particularly successful in
tuberculosis. The authors investigated the effect on the cohiform group of organisms,
commonly the cause of urinary tract infections, of combinations of streptomycin with
chloramphenicol or tetracycline. The testing was clone in vitro and the technique is
described. Streptomycin plus tetracycline and streptonlycin plus chloramphenicol
proved to be the most effective combinations for suppressing resistant variants while
at the same time maintaining bactericidal activity. The latter feature is considered
an important factor in the prevention of relapses in urinary tract infections. The in-
vestigations did not include a clinical trial of the value of these antibiotic combina-
tions but the in vitro tests indicate that good results are to be expected in application
in clinical practice.

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Combined Antibiotic Therapy for the Suppression of Resistant Variants in Urinary
Infection
Pediatrics 1956;17;509

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 Combined Antibiotic Therapy for the Suppression of Resistant Variants in Urinary
Infection
Pediatrics 1956;17;509

The online version of this article, along with updated information and services, is located on
the World Wide Web at:
http://pediatrics.aappublications.org/content/17/4/509

Pediatrics is the official journal of the American Academy of Pediatrics. A monthly publication, it has
been published continuously since 1948. Pediatrics is owned, published, and trademarked by the
American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village, Illinois, 60007.
Copyright © 1956 by the American Academy of Pediatrics. All rights reserved. Print ISSN: 1073-0397.

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