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A mis asesores los Drs. Manuel Palomino Yamamoto y Pablo Enrique Bonilla por su invalorable
apoyo en la Dirección de la ejecución de la investigación.
Al Dr. Ricardo Reyes Chilpa, Profesor Investigador del Instituto de Química de la
Universidad Autónoma de México por haberme permitido trabajar con su asesoría dentro del
laboratorio de pruebas biológicas.
Al Dr. Benjamín Castañeda Castañeda, Director del Instituto de Investigación de la Facultad
de Medicina de la Universidad San Martín de Porres por todo el apoyo y las facilidades
brindadas.
A la Dra. Augusta Córdova Rivera, por haberme apoyado en la culminación de mi trabajo de
tesis doctoral.
A mi esposo Luis miguel Chávez Córdova, mis hijos BORYS BRYAN y JOSE LUIS por
haberme acompañado con entereza, entrega y amor en la realización de la presente investigación.
A mi Madre carolina y mi padre Alberto por todo el amor que me profesaron siempre y a
quienes agradezco el haberme dado la vida.
A Dios por todas las cosas bellas que me ha dado durante mi vida.
AGRADECIMIENTOS ESPECIALES
A los Miembros del Jurado Informante:
Dr. Ernesto Raez Gonzáles(PRESIDENTE)
Dr. Jorge Arroyo Acevedo(Miembro)
Dr. Pablo Enrique Bonilla Rivera (Miembro)
A los Miembros del Jurado Examinador:
Dr. Ernesto Raez Gonzáles (PRESIDENTE)
Dr. Manuel Palomino Yamamoto (Miembro)
Dra. Nancy Lozano Reyes(Miembro)
Dr. Jorge Arroyo Acevedo(Miembro)
Dr. Pablo Enrique Bonilla Rivera (Miembro)

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La presente investigación ha tenido por objetivos evaluar la actividad citotóxica, antimitótica,
antimutagénica y antiviral del extracto metanólico al 10% p/v de hojas de Calophylum
brasiliense Cambess de la zona de Satipo.
MATERIAL Y METODOS: Se utilizaron métodos estandarizados de acuerdo all Manual de
Técnicas del CYTED y según Skehan, Gustafson y Simmons.
RESULTADOS: Se observó un buen efecto citotóxico en el bioensayo en Artemia salina
con una CL50 (Concentración Letal Media) = 70.5 ppm, con un limite superior e inferior al 95%
de 136.50ppm y de 36.4ppm de acuerdo al método de Probits, observándose una inhibición sobre
líneas celulares tumorales U251, PC-3, HCT15, MCF7 y K562 de 109.42%, 95.67%, 96.16%,
102.68% y 95.69% respectivamente con una p< 0,01. En la evaluaciòn antimitòtica en cebolla, al
cabo de 6 horas de tratamiento el índice mitótico de las células meristemáticas decreció de un
IM= 13 del control a un IM = 1.0 a la concentración de 0.5% a 25ºC.
Con respecto a la evaluaciòn antimutagénica en erizo de mar los resultados no fueron
estadísticamente significativos a las concentraciones ensayadas.
La actividad antiviral del extracto metanólico sobre la Transcriptasa Reversa (RT) del
HIV-1, realizada con el Kit Lenti RT(Cavidi Tech), presentó una CL50 de 70.2905 ug/ml con un
límite superior e inferior al 95% de 138.89ug/ml y 35.5707ug/ml. Asimismo en el extracto se
observó la presencia de: alcaloides, cumarinas, lactonas, triterpenos, entre otros, habiéndose
aislado tres compuestos CBHS5, CbHS16 y CbHS525354 los cuales han sido analizados
utilizando técnicas espectroscópicas de IR, RMNH1, RMNC13 y EM.
DISCUSIÓN: Los compuestos aislados podrían estar implicados en la acción farmacológica
antitumoral y antiviral.
CONCLUSIÓN: El extracto de Calophylum brasiliense de la zona de Satipo presenta un
buen efecto citotóxico, antitumoral, antimitótico y antiviral sobre el virus del SIDA.
Palabras Claves: Calophylum brasiliense, citotoxicidad, antimitótico, antiviral,
embriotoxicidad, alcaloides, cumarinas, Cáncer, SIDA.
Cytotoxic, antimitotic, antimutagenic and antiviral evaluation of Calophylum
brasiliense

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The purpose of the present investigation was to evaluate cytotoxic, antimitòtic, antimutagenic
and antiviral the activity of the methanolic extract to 10% p/v of leaves of Calophylum
brasiliense Cambess of Satipo.
MATERIAL Y METHODS: being used several experimental models of CYTED, Skehan,
Gustafson y Simmons.
RESULTS: Citotoxic effects: The extract has a good citotoxic effect evaluated in Artemia
salina with a CL50 of 70.5 ppm (with 95% confidence limits of 36.4-136.5 ppm). Also there is
an inhibitory effect over cellular tumoral lines U251,PC-3, HCT15,MCF7 and K562 (109.42,
95.67, 96.16, 102.68, and 95.69% respectivelly, p<0.01)
Antimitotic effect; Was evatuated in Allium cepa meristemic cells. Ther was a decrement in
the mitotic index from 13 to 1 working with a concentration of 0.5% at 25°C.
Antimutagenic activity: There was no observable effects at concentrations up to 15 ppm in
embrionic development of fecundated eggs of Sea urchin.
Antiviral effects were evaluated by the method of HIV-1 Reverse Transcriptase inhibition.
There was a CL50 of 70.3 ug/ml (with 95% confidence limits of 35.6-138.9 ppm).
Phyitochemical evaluation: The methanolic extract of Calophylum brasiliense contains
alcaloids, cumarines, lactones, triterpenes. We have been able to isolate three compounds with
the provisional names of CbHS5, CbHS16 and CbHS525354.
DISCUSSION: The composeds observing can presented an good effect pharmacologycal
antitumoral y antiviral.
CONCLUSION: The extract of Calophylum brasiliense of Satipo presented an good
inhibitory effect of Cancer y SIDA.
Key Words: Calophylum brasiliense, citotoxicity, antimitotic, antiviral Embriotoxicity,
alkaloids, cumarinas, Cancer, AIDS.
Cytotoxische, antimitotic, antimutagenic und Antiviren auswertung von Calophylum
brasiliense

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79
Der Zweck der anwesenden Untersuchung war, cytotoxisches, antimitotiches, antimutageniches
und Antiviren die Tätigkeit des metanolic extraktes bis 10% p/v von Blättern von Calophylum
brasiliense Cambess auszuwerten, das einigen experimentellen Modellen verwendet wurde.
Citotoxic Effekte: Der Extrakt hat einen guten citotoxic Effekt, der im Artemie Salina mit
einem CL50 von 70.5 PPMS ausgewertet wird (mit das 95% Vertrauen Begrenzungen auf
36.4-136.5 PPMS). Auch es gibt zellulare tumoral Linien eines hemmenden Effektüberschusses
U251, PC-3, HCT15, MCF7 und K562 (109.42, 95.67, 96.16, 102.68 und 95.69% respectivelly,
p < 0.01.
Antimutagenic Tätigkeit: Es gab keine Observable effekte bei Konzentrationen, bis, das 15
PPMS in der embrionic Entwicklung von Eier des Seeigels fecundated.
Antivireneffekte wurden durch die Methode HIV-1 der Rücktranscriptase Hemmung
ausgewertet. Es gab CL50 von 70.3 ug/ml (mit das 95% Vertrauen Begrenzungen auf 35.6-138.9
PPMS).
Phyitochemical Auswertung: Der Methanol- Extrakt von Calophylum brasiliense enthält
Alkaloide, cumarines, Laktone, Triterpene. Wir sind in der Lage gewessen, drei Mittel mit den
provisorischen namen von CbHS5, von CbHS16 und von CbHS525354 zu lokalisieren.
SCHLÜSSELWÖRTER: Calophylum brasiliense, citotoxicity, antimitotic,
Antivirenembriotoxicity, Alkaloide, coumarins, Krebs, AIDS.

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