06-07-2017

Dr. Edgar Pastene

2016

1
 06-07-2017

Maqui:
Antocianos
(ANC)
disminuyen la
glicemia en
animales
diabticos

2
 06-07-2017

Maqui: Antocianos
(ANC)Aumentan la captacin de
glucosa en tejidos perifricos

Maqui: Antociano aislado D3S5G

(disminuye la glicemia en
animales diabticos

3
06-07-2017

4
 06-07-2017

Islote pancretico

Dao provocado por la Corazn

especie reactiva
peroxinitrito en
diferentes tejidos de Rin
Un paciente diabtico

Nervio Sitico

Retina

Maqui: Antocianos (ANC)

reducen el dao oxidativo en
corazn isqumico

5
06-07-2017

6
06-07-2017

7
06-07-2017

8
06-07-2017

9
06-07-2017

10
06-07-2017

11
06-07-2017

12
06-07-2017

13
 06-07-2017

Glycirrhyza foetida Amorpha frutcticosa

14
 06-07-2017

NEURODEGENERACION?
LPS SINDROME METABOLICO

CNCER OBESIDAD

Fondecyt 1120290: Reduction of fat absorption, endotoxinemia and low

grade inflammation by dietary proanthocyanidins as a strategy for the
prevention of metabolic syndrome and its complications - An in vitro,
animal and human study.

15
 06-07-2017

El p-cresol es un
Metabolito bacteriano
Con efectos
genotoxicos

mayo 2016

Las proantocianidinas y sus metabololitos protegen el dao

por p-cresol en el intestino grueso

16
 06-07-2017

100

re s p e c t to th e c o n tro l a t t0
p = 0 .0 0 2 4
p = 0 .0 1 9 5

F o ld in c r e a s e o f F D - 4
150 100 p = 0 .0 0 4 3

re s p e c t to th e c o n tro l a t t0
p = 0 .0 0 1 2
p = 0 .0 2 1 2 80

F o ld in c r e a s e o f F D -4
p = 0 .0 2 5 2 p = 0 .0 0 0 3

( % o f in it ia l v a lu e )
p < 0 .0 0 0 1 80
60 p = 0 .0 0 4 4
p < 0 .0 0 0 1
100
TEER 60 p < 0 .0 0 0 1
40

40
50 20

C ra n b e rry P A C s 20
0
( g /m L ) A vocado P A C s
0mM 0 1 2 .5 25 50
0 C ra n b e rry P A C s
0 ( g /m L )
C o n tro l 0 1 2 .5 25 50 ( g /m L ) p -c r e s o l 3 .2 m M C o n tro l 0 1 2 .5 25 50
p -c r e s o l 3 .2 m M
p -c r e s o l 3 .2 m M

p = 0 .0 3 0 3
150
p = 0 .0 2 3 6
100

re s p e c t to th e c o n tro l a t t0
p = 0 .0 0 3 1
150
p = 0 .0 0 0 7
( % o f in it ia l v a lu e )

p = 0 .0 0 3 9

F o ld in c r e a s e o f F D -4
p < 0 .0 0 0 1
80

( % o f in it ia l v a lu e )
p = 0 .0 0 8 4
100 p < 0 .0 0 0 1
p = 0 .0 0 1 5
TEER

100
60

TEER
p < 0 .0 0 0 1

50 40
50

20
G ra p e P A C s
0 G ra p e P A C s
C o n tro l 0 1 2 .5 25 50 ( g /m L ) 0 A vocado P A C s 0 ( g /m L )
C o n tro l 0 1 2 .5 25 50 ( g /m L ) C o n tro l 0 1 2 .5 25 50
p -c r e s o l 3 .2 m M
p -c r e s o l 3 .2 m M p -c r e s o l 3 .2 m M

Las
Procianidinas
p = 0 .0 1 8 1
150
100 p = 0 .0 0 1 6
re s p e c t to th e c o n tro l a t t0

protegen
p = 0 .0 1 3 4

( % o f in it ia l v a lu e )
F o ld in c r e a s e o f F D -4

p < 0 .0 0 0 1
80 p = 0 .0 3 0 7

restituyen la
100

TEER
p = 0 .0 0 0 7
60

integridad
p < 0 .0 0 0 1

50
40

20
celular en
intestino
A p p le P A C s
0
A p p le P A C s ( g /m L )
0 C o n tro l 0 1 2 .5 25 50
( g /m L )
C o n tro l 0 1 2 .5 25 50
p -c r e s o l 3 .2 m M
p -c r e s o l 3 .2 m M

p < 0 .0 0 0 1
150 100
re s p e c t to th e c o n tro l a t t0

p < 0 .0 0 0 1
F o ld in c r e a s e o f F D - 4

p = 0 .0 6 5
( % o f in it ia l v a lu e )

p = 0 .0 0 3 3 80
p = 0 .0 0 1 6
100
60
TEER

p < 0 .0 0 0 1

40
50

20

0 3 -P P A 3 ,4 -D H P P A
0
C o n tro l 0 50 200 ( M ) ( M )
C o n tro l 0 30 100

p - c r e s o l 3 .2 m M p - c r e s o l 3 .2 m M Los metabolitos
colnicos de las
Procianidinas
p = 0 .0 0 0 4
150 150
p = 0 .0 1 6 6 p = 0 .0 0 8 1

tambin
( % o f in it ia l v a lu e )
( % o f in itia l v a lu e )

p < 0 .0 0 0 1 p < 0 .0 0 0 1

protegen y
100 100
TEER

TEER

50 50 restituyen la
integridad
celular en
4 -H P A A 3 ,4 -D H P P A
0 0
C o n tro l 0 10 50 ( M ) C o n tro l 0 30 100 ( M )

p - c r e s o l 3 .2 m M p - c r e s o l 3 .2 m M
intestino

100
re s p e c t to th e c o n tro l a t t0

100
re s p e c t to th e c o n tro l a t t0

p = 0 .0 0 3 6
F o ld in c r e a s e o f F D -4

F o ld in c r e a s e o f F D -4

p = 0 .0 0 0 3
80 80
p = 0 .0 0 0 6
p = 0 .0 0 8 1

60 60 p < 0 .0 0 0 1
p < 0 .0 0 0 1

40 40

20 20

4 -H P A A 3 -P P A
0 0
C o n tro l 0 10 50 ( M ) ( M )
C o n tro l 0 50 200

p - c r e s o l 3 .2 m M p - c r e s o l 3 .2 m M

17
06-07-2017

18
06-07-2017

19