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PI3K / Akt Signaling

BCR
Cytokine
Receptor Ag
RTK CD19

Integrin mIg / / GPCR

mIg

BCAP

PI3K

PI3K
Jak1
IRS-1
Gab1

Syk
PI3K

Lyn
FAK

PI3K
Gab2
PI3K

G
G GTP
Paxillin

GL Rictor
ILK
mTOR
Akt
PIP3 PTEN Sin1 PIP3 PTEN PP2A PHLPP CTMP

Membrane
PDK1 PDK1 Membrane Organization
Recruitment Recruitment LaminA of Nuclear
S6 and Activation and Activation
Proteins
Protein Synthesis

Tpl2 NF-B

Other
p70 S6K IKK Pathway
Cardiovascular
PDCD4 GL TSC2 eNOS Homeostasis
TSC1
mTOR Synaptic
GABAA
Raptor Signaling
PRAS40
Akt
Huntingtin Blocks

science
Inhibits XIAP
Apoptosis Aggregation
Ataxin-1 Promotes
MDM2

Neuro
FoxO1 Neuroprotection
PFKFB2 Aggregation
Bad GSK-3
p53 Neurodegeneration
14-3-3
Bim
PIP5K AS160
Glycolysis
Bcl-2

Bax Glycogen
Su

Wee1 Myt1 p27 Kip Synthase Glucose

rvi

sm

Transport
va

oli
l

Apoptosis
ab

p21 Cip
et

Cytosolic
M

Glycogen se
Sequestration u co
Cyclin D1
Synthesis Gl

Cell Cycle

Proliferation

2003 2010 Cell Signaling Technology, Inc. PI3K / Akt Signaling created January 2003 revised November 2010
 www.cellsignal.com

Signaling Pathways Key

Direct Stimulatory Modification

Kinase
Direct Inhibitory Modification
Phosphatase
Multistep Stimulatory Modification
Transcription Factor
Multistep Inhibitory Modification
Caspase
Tentative Stimulatory Modification

Receptor Tentative Inhibitory Modification

Enzyme Transcriptional Stimulation

Transcriptional Inhibition
Cyclin, pro-apoptotic
Translocation
pro-survival
Separation of Subunits or Cleavage Products
GAP / GEF
Joining of Subunits
GTPase

G-protein, ribosomal subunit

Acetylase

Deacetylase

2003 - 2010 Cell Signaling Technology, Inc.