CURRICULUM VITAE

INVESTIGATOR NAME: Andrs Francisco Alvarisqueta INVESTIGATOR NACIONALITY: Argentine LICENSE NUMBER: 9200 STUDY LOCATION ADDRESS: Centro de Investigaciones M dicas C!"nica de #ract$ras % Orto&edia Av! Inde"endencia #$%&' (%)00*+, Mar del -lata' (s! As!' Argentina Tel! 022./$9$2&%&0 Fa1 022./$9&9%09 EDUCATION: List Co!!eges' Universities attended (it) dates and degrees o*tained #9%&/#9 0 Universidad 2acional de (uenos Aires! Facultad de Medicina Degree3 -45sician +OSGRADE: S&ecia!it%, dates, instit$tion-s na.e #9 2/#9 &3 Residenc5 C4ie6 o6 Internal Medicine! +os"ital -rivado de Co7unidad! Mar del -lata #9993 *ensito7etrist! International 8ociet5 6or Clinical *ensito7etr5! 200./200&3 Master in Clinical Far7acolog5! Universidad A9ierta Intera7ericana! :U2 200) :ournals o6 ;C- 8cienti6ic Met4ods and ;C-! *ictated 95 *r Ru9en Iannantuono! Mar del -lata +RO#ESSIONAL E/+ERIENCE3 0 Board certi1ication' Na.e o1 *oard: 8"ecialist in Internal Medicine! Colegio de Mdicos de la -cia! *e (uenos Aires I< *istrito #9 ) 2 +revio$s a&&oint.ents 3 List &ositions )e!d, gives dats and instit$tions4: #9 2/#9 &3 Residenc5 C4ie6 o6 Internal Medicine! +os"ital -rivado de Co7unidad! Mar del -lata #9 .3 Residenc5 C4ie6 =$ 7ont4> #9 $3 E1ternal "45sician?s @66ice o6 internal 7edicine! +os"ital -rivado de Co7unidad! Mar del -lata #9 &3 Residenc5 c4ie6 o6 Internal Medicine! +os"ital -rivado de Co7unidad! Mar del -lata #9 )3 Residenc5 Instructor o6 Internal Medicine! +os"ital -rivado de Co7unidad! Mar del -lata #9 %/#9 93 E7ergenc5 roo7 "45sician! +os"ital -rivado de Co7unidad! Mar del -lata #990/200.3 Clinical Medicine service coordinator! ClAnica de Fracturas 5 @rto"edia! Mar del -lata 200./200%3 Me79er o6 Unidad de Ensa5os ClAnicos! ClAnica ColBn! Mar del -lata 2 +resent a&&oint.ent: 8ince #992' Coordinator o6 *1As service! Centro de @steo"atias Meta9Blicas 8ince #992' Medical *irector! Centro de @steo"atAas Meta9Blicas 8ince 200)' Medical *irector Centro de Investigaciones Mdicas! ClAnica de Fracturas 5 @rto"edia Mar del -lata!

+RO#ESSIONAL E/+ERIENCE IN CLINICAL INVESTIGATION:

Alendronate @nce CeeDl5 vs @nce *ail5 -re6erent! -4ase IV @steo"orosis! Antirea9sortive! -rinci"al Investigator! C+ARI8MA -4ase III Cardiovascular -revention! Anti"latelets! 2002/200&! -rinci"al Investigator! CVT# -4ase III Cardiovascular *iagnostic' Isc4e7ia 7arDer Eualit5 Assurance! 200$! 8u9 Investigator! CVT2 -4ase III Isc4e7ia 7arDer Eualit5 Assurance! 200&! 8u9 Investigator! @A8I8 ) -4ase III Acute isc4e7ic' isc4e7ic 7arDer! 200&/200)! Co investigator! @RI;I2 -4ase III *ia9etes! Cardiovascular "revention! 200&/200)! Co investigator!

CLAF 2.0 -4ase III *ia9etes! 200&/200%! -rinci"al Investigator! CLAF 2.#0 -4ase III *ia9etes! 200&/200%! -rinci"al Investigator! 8ERE2A*E -4ase III *ia9etes! 200&/200)! -rinci"al Investigator! 8IA*+ -4ase III *ilutional +5"onatre7ia Acuaretic! 200&/200)! -rinci"al Investigator! *ILI-@ -4ase III *ilutional +5"onatre7ia Acuaretic! 200&/200)! -rinci"al Investigator! AT+E2A -4ase III Atrial 6i9rilation! 200&!-rinci"al Investigator! 8FR$%2/00% -4ase II *ia9etes! 200%! -rinci"al Investigator (selected center, not initiated study) @-I/00# -4ase III *ia9etes! 200%! -rinci"al Investigator (selected center, not initiated study) @-I/002 -4ase III *ia9etes! 200%! -rinci"al Investigator (selected center, not initiated study) @LE -4ase III 5 III9 *ia9etes! 200%! -rinci"al Investigator (selected center, not initiated study) *RIVE -4ase II TV- -ro6ila1is enti II anti <! 200)/200%! -rinci"al Investigator! CLAF2.. -4ase III *ia9etes! 200%/200 ! -rinci"al Investigator! CG@L$$)M2.09 -4ase III @steos"4orosis! 8ince 200%! -rinci"al Investigator! R@C,ET -4ase III! Atrial 6i9rilation! 200%/20#0! -rinci"al Investigator! EFC#0.$2 +I- # +i" re"lace7ent! 200 /2009! -rinci"al Investigator! EFC#0.$. +I- 2 +i" 6racture! 200 /2009! -rinci"al Investigator! EFC#0&%# ,nee ,nee re"lace7ent! 200 /2009! -rinci"al Investigator! RA*IU8 -4ase II @steo"orosis in Ho7an! 200%/2009! -rinci"al Investigator! CRE8CE2*@ -4ase III Cardiovascular risD! 200%/200 ! -rinci"al Investigator! *#) 0C0002 -4ase III9! 200 /2009! -rinci"al Investigator! (I #2# !# -4ase III! 200 /2009! -rinci"al Investigator! ;ET;@AL < *ia9etes! 200 /20##! -rinci"al Investigator! CLAF 2.#.% (ad controlled dia9etes Hit4 renal 6ailure! 8ince 200 ! -rinci"al Investigator! (C2#%#. *ia9etes! 8ince 2009! -rinci"al Investigator! RA* 00/00# @9servational stud5! +ot 6las4es! 200 /2009! -rinci"al Investigator! RA*#90#002 +ot 6las4es! 200 /2009! -rinci"al Investigator! (I#2$&!9 -4ase II *ia9etes! 8ince 2009! -rinci"al Investigator! (I#2$&!#0 -4ase II *ia9etes! 8ince 2009! -rinci"al Investigator! (@REALI8 -4ase III Atrial 6i9rilation! 200 /20#0! -rinci"al Investigator! ATLA8 II -4ase II Acute coronar5 sindro7e! 8ince 2009 ! -rinci"al Investigator! *A-A #0 -4ase III9 *ia9etes! 8ince 20#0! -rinci"al Investigator! CACG -4ase II9 5 III *ia9etes! 8ince 20#0! -rinci"al Investigator! *IA.00 -4ase III *ia9etes! 8ince 20#0! -rinci"al Investigator! AFICI@2A*@ -4asee IV! *ia9etes! 8ince 20#0! -rinci"al Investigator! TEC@8 -4ase III! *ia9etes! 8ince 20#0! -rinci"al Investigator! F@RE8T -4ase III! *ia9etes! 8ince 20#0! -rinci"al Investigator! +@,U8AI -4ase III! TV-0E-! 20#0/20#2! -rinci"al Investigator! *#) 0C000. -4ase IV! 8ince 20#0! -rinci"al Investigator! C+IE8I -4ase III E"oc! 8ince 20#0! Co investigator! A*C##. %$ -4ase III! E"oc! 8ince 20##! Co investigator! -E;A8U8 -4ase III! 8ince 20#0! -rinci"al Investigator! CLCG)9)(2.#$ -4ase III! 8ince 20##! -rinci"al Investigator! EFC##.#9 -4ase III! 8ince 20##! -rinci"al Investigator! IMA;I2E 2 -4ase III! *ia9etes! -rinci"al Investigator! *& 9)C0002% -4ase IV Ast47a! 8ince 20#2! 8u9 Investigator! +GC##.% 2 -4ase III E"oc! 8ince 20#2! 8u9 Investigator! +GA#0) &. -4ase III E"oc! 8ince 20#2! 8u9 Investigator! CEA(#$9(2$0# -4ase III E"oc! 8ince 20#2! -rinci"al Investigator! (.*/EC/;+*C -4ase IV @steo"4orosis! 8ince 20#2! -rinci"al Investigator! EUCLI* -4ase III9 -eri"4eral vascular disease! 8ince 20#.! -rinci"al Investigator! CA2T@8 Acute 75ocardial in6arction! 8ince 20#.! -rinci"al Investigator! @*F88EF -4ase III9! Acute coronar5 s5ndro7e! 8ince 20#.! -rinci"al Investigator! 8A8##&.& Fase III9! Ast47a in C4ildren! 8ince 20#.! 8u9 Investigator! :A*G -4ase III R4eu7atoid Art4ritis! 8ince 20#.! 8u9 Investigator (recruiting) :A*V -4ase III R4eu7atoid Art4ritis! 8ince 20#.! 8u9 Investigator (recruiting)

DATE:

SIGNATURE: