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prospective study
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[Valores pretratamiento e inducidos por el de enolasa especffica de neurona en pacientes con
cancer de pulm6n microcftico: estudio prospectivo, abierto]
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Emin Erbaycu, A.a ~. Gunduz, A.0, Batum, a.a, Zeren Ucar, z, Tuksavul, F.a, Zek1 Guell.I, S.a 6
' Department of Thoracic Diseases, Izmir Or Suat Seren Thoracic Diseases and Surgery Training and Research Hospital, Izmir,
Turkey
Department of MicrobiOlogy, Izmir Dr Suat Seren Thoracic Diseases and Surgery Training and Research Hospital, Izmir,
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Background: Neuron-specific enolase (NSE) is the most sensitive tumor marker for small-cell lung carcinoma (SCLC) at the time of diagnosis. The main
purpose of this study was to review the usefulness of serum NSE level as a prognostic factor in patients with SCLC and to determine the correlation
between the NSE level and the stage of disease and response to chemotherapy. Methods: In this prospective study, patients with SCLC were evaluated for Xue, F., Wang, l., Zhang, IA.
response to chemotherapy, sul\lival without disease progression, Ctil'Ocal sigl'Oficance of detection of serum values of
and overall sulVival. The end point was designated at patient death due to SCLC. NSE assays were pertormed before and after completion of chemotherapy. neuron specific enOlase before and after treatment
Results: Sixty-five patients were included in study. NSE levels were significantly higher in patients Who died of SCLC. The pre-treatment NSE levels in for small celt lung cancer
(2011) Chinese Joumel of Lung Cencer
patients Who responded to treatment were significantly lower. The post-treatment NSE levels were not significantly correlated with response to chemotherapy,
progression-free sul\lival, overall sul\lival, and prognosis of patients. Change in the NSE level between the pre- and post-treatment periods was not
significantly correlated with response to treatment, progression-free sul\lival, and overall surevat. Conclusions: NSE levels might not be related with the stage Jorgensen, L G.M
of the disease. However, a low pre-treatment NSE level might be used in predicting good Heuron specific enotase in sman cell lung
response to chemotherapy in patients with SCLC. The post-treatment serum NSE levels and the rate of change between pre- and post-treatment serum levels of cancer. Oil'Ocal and biochemical evaluatioo
Language of original
NSE were document
not related with response to chemotherapy, progression-free sulVival, and overall sulVival. 2009 SEPAR. (1999) Danish MedicalBulletin
Spanish
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IB Find potential More Cydometalated gold(lll) 1m1nophosphoranes which
authormatches incorporate carbohydrate groups
(2012) Journal of Organomerall1cChemistry
History Caubet A, Bosque R, Moll'\s E , Barros, F J , Luna. F
Publicationrang 1975-Present Study of the ditterent behaviour of thiazolin and thiazin
e Chemical Oommurucanons ~ View 1ndazole derivabves with palladium(ll) acetate
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Archlvos de BronconeumOlogia
Volume 46, Issue 7, July 2010, Pages 364-369
ISSN: 03002896 ..,. View references Han. J . Zlluo. f , Chai Y' -0
COOEN: ARBRO (21) Novel electrochemical catalysis as signal
DOI: amplified strategf for label-free detectioo of
10.1016/j.arbres.2010.04.005 neuron.specific enOlase
PubMedD: 20537457 (2012) Blosensors and Bloelearomcs
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I Cltntcal significance of detecbon of serum values of
neuron specific enOlase before and after treatment
Pre-treatment and Treatment- neuron-specific in patients with small-cell lung cancer: An for small ceH lung cancer
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Emin Erbaycu, A.a ~. Gunduz, A.0, Batum, a.a, Zeren Ucar, z, Tuksavul, F.a, Zek1 Guell.I, S.a 6
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