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The drug has to pass through the stratum corneous and spread to the epidermis and dermis
from where it accesses the blood circulation. The methods that describe the kinetics of
transdermal absorption are based on the laws of diffusion and the behavior of the organism.
The passive diffusion of a molecule through the skin depends on its concentration and its
gradient towards the different subcutaneous layers, from the outer layer to the deepest layer.
The characteristics of the transport through the skin can be deduced from the diffusion
properties on the stratum corneous and allows us to use the laws of Fick as a theoretical basis
for the transport of a molecule through the skin.
The figure show that outside the distribution phenomenon in the interface, the concentration
profile of a molecule is determined by the decrease in concentration in the stratum corneum
that acts as a barrier.
In the description, D is the half diffusion coefficient and do not have in count the internal
structure of corneo stratum. The values of are unknown, so we assume that k has a unique
value and
El flujo j de fármaco que atraviesa la piel puede ser considera como la cantidad de principio
activo que la atraviesa por unidad de superficie y tiempo.
Es la cantidad de principio activo que atraviesa la piel en un intervalo de tiempo y S la
superficie de difusión.
A partir de la ecuación 2 y 5, por integración en función del tiempo y considerando un modelo
en el que es constante la concentración en la fase dadora (dosis infinitas) es posible obtener
la expresión teorica de la cinetica paso de una molecula.
El alphazolam