Resultados

Ejercicio 7.2

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 71.54 71.50
Kd(h-1) 0.7561 0.75
t1/2(h) 0.9166 0.91
Vd(mg)/(mcg/L) 0.0139 0.0139
CL(mg)/(mcg/h) 0.0105 0.0105
ABC 0-t(mcg/mL/h) 85.83 84.81
ABC0-∞(mcg/mL/h) 95.36 94.62

Ejercicio 7.6

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 369.7 371.22
Kd(h-1) 0.616 0.6192
t1/2(h) 1.15 1.11
Vd(mg)/(mcg/L) 13.51 13.46
CL(mg)/(mcg/h) 8.3 8.34
ABC 0-t(mcg/mL/h) 585.10 584.9093
ABC0-∞(mcg/mL/h) 600.50 599.50
 Ejercicio 7.7

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 2.5393 2.4919
Kd(h-1) 0.4140 0.4071
t1/2(h) 1.6739 1.7025
Vd(mg)/(mcg/L) 14.76 15.04
CL(mg)/(mcg/h) 6.11 6.12
ABC 0-t(mcg/mL/h) 5.57 6.01
ABC0-∞(mcg/mL/h) 5.66 6.12
Ejercicio 7.8

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 7.36 7.40
Kd(h-1) 0.1771 0.1796
t1/2(h) 3.9130 3.85
Vd(mg)/(mcg/L) 27.17 27.01
CL(mg)/(mcg/h) 4.80 4.85
ABC 0-t(mcg/mL/h) 37.705 36.42
ABC0-∞(mcg/mL/h) 42.67 41.19

Ejercicio 7.9

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 7.3026 7.4123
Kd(h-1) 0.5823 0.5885
t1/2(h) 1.1840 0.085
Vd(mg)/(mcg/L) 13.693 14.54
CL(mg)/(mcg/h) 8.0145 8.55
ABC 0-t(mcg/mL/h) 12.3256 11.31
ABC0-∞(mcg/mL/h) 12.7014 11.68
 Ejercicio 7.10

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 31.2702 31.4149
Kd(h-1) 0.2264 0.2279
t1/2(h) 3.0609 3.0410
Vd(mg)/(mcg/L) 7.9948 8.0338
CL(mg)/(mcg/h) 1.81 1.8311
ABC 0-t(mcg/mL/h) 130.99 127.58
ABC0-∞(mcg/mL/h) 140.27 136.52

Ejercico 8.2

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 47.3422 47.22
Kd(h-1) 0.3265 0.3249
t1/2(h) 2.1225 2.1330
ABC 0-t(mcg/mL/h) 103.25 102.17
ABC0-∞(mcg/mL/h) 103.54 102.23
Ka( h-1) 1.159 1.096
t1/2 ka(h) 0.5979 0.6322
 Ejercicio 8.3

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 155.42 153.25
Kd(h-1) 0.443 0.4294
t1/2(h) 1.5643 1.6129
ABC 0-t(mcg/mL/h) 18.04 17.01
ABC0-∞(mcg/mL/h) 20.66 19.61
Ka( h-1) 0.4318 0.4547
t1/2 ka(h) 1.6049 1.52
C max mcg/mL 3.42 3.18
T max(h) 2.45 2.26

Ejercicio 8.4

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 7.89 7.79
Kd(h-1) 0.022 0.021
t1/2(h) 31.35 31.59
ABC 0-t(mcg/mL/h) 263.26 263.28
ABC0-∞(mcg/mL/h) 288.14 288.82
Ka( h-1) 0.1136 0.1173
t1/2 ka(h) 6.10 5.90
C max mcg/mL 7.89 4.30
T max(h) 17.89 17.57
 Ejercicio 8.5

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 5.33 6.76
Kd(h-1) 0.1973 0.2264
t1/2(h) 3.51 3.06
ABC 0-t(mcg/mL/h) 16.04 15.99
ABC0-∞(mcg/mL/h) 21.99 20.85
Ka( h-1) 1.0554 0.79
t1/2 ka(h) 0.6566 0.92
C max mcg/mL 2.77 2.81
T max(h) 2.25 2.28

Ejercicio 8.7

Parámetro Manual Programa PK SOLVER)

CP°(mcg/mL) 155.32 164.49
Kd(h-1) 0.2154 0.414
t1/2(h) 3.21 1.67
ABC 0-t(mcg/mL/h) 88.00 89.52
ABC0-∞(mcg/mL/h) 96.5 91.78
Ka( h-1) 1.12 0.5339
t1/2 ka(h) 0.61 1.28
C max mcg/mL 18.54 15.88
T max(h) 1.24 2.10