For nearly a century, the drug trial process has remained the same. Researchers use animal testing before advancing drugs to human clinical trials. But this method is imperfect. Animal models are not replicative of the human body, so the failure rate

Most Innovative Companies At the height of the COVID-19 pandemic, as governments struggled to disperse information and aid, Unqork, an enterprise-software development platform, was ready to lend a hand. The company, often given deadlines of only a fe

Most Innovative Companies For many patients, orthopedic surgery is a quality-of-life saver. It can relieve pain and restore function to their bones and joints, helping keep them active—whether it’s running a 5k or simply getting dressed by themselves

WHETHER IRRITATED BY POLLEN OR DOG hair, ocular allergy sufferers are all too familiar with inflamed eyes and the painful routine of rubbing, reddening, and soreness. When contact-lens wearers get those allergies—and 40% do—a quick rub can risk joggi

The Presidio Tunnel Tops, opening to the public on July 17, caps more than 25 years of transformation at the Presidio, a 1,500-acre national park set on a former military base. Since the mid-’90s, the land (which includes the Crissy Field recreation

Most Innovative Companies For the past 30 years, Myriad Genetics has been involved in genetic testing to help women determine their risk of breast cancer. Typically, about 5% of women test positive for a high-risk genetic mutation. For them, heighten

KROLL SHOW “Let’s make her the CEO. You think she’d be doing publicity, but really, she’s a strong woman who knows how to run a business.” KROLL SHOW “He’s the one who coined ‘Good at Business.’ He’s probably very into crypto right now, in a very dan

Most Innovative Companies Tommy Palm founded Resolution Games in 2015 with a mission: to create a studio focused on expanding the boundaries of immersive virtual reality (VR) and augmented reality (AR) technologies to build games in which connection,

FOR GERI CUPI, FOUNDER AND CEO of Twig, a U.K. startup building financial solutions for the circular economy, the main challenge facing his business is the landfill—the tendency we have to toss out old stuff. Cupi launched Twig’s “Bank of Things” in

Most Innovative Companies The monitoring of vital signs is an essential component in a patient’s healthcare. But numerous factors can diminish their accuracy and usefulness. In a hospital, for example, constant monitoring involves both time- and labo

Most Innovative Companies At age 18, Cole Mason left Texas to pursue a modeling career in New York City. He had a hard time gaining traction in the fashion industry and was forced to come up with a Plan B. While working as a nightclub promoter, Mason

THE NEW SOLAR SHINGLES FROM GAF Energy, a spin-off of the world’s largest roofing company, can be nailed directly to the roof like ordinary shingles. Since the roofing industry is 20 times larger than the solar industry, the company hopes it can spee

The pandemic devastated the U.S. job market. Millions lost jobs in the spring and summer of 2020, as consumer spending plummeted in a stay-at-home landscape. Over the following two years, a historic labor shortage—partially fueled by the Great Resign

Most Innovative Companies Global trust in Big Tech, long plagued by issues of privacy and overreach, hit a record low last year. Yet technology continues to dominate our lives, and the COVID-19 pandemic has only magnified its influence. “As algorithm

YOU DON’T GARNER 15 GRAMMYS ACROSS A TWO-DECADE-LONG CAREER without a strong work ethic. Alicia Keys, the artist with the dynamic voice and extraordinary songwriting and producing talent, developed hers at an early age. Her role model was her mother,

Most Innovative Companies Cardiologists have long been confounded by a particular problem in treating patients with buildups of hard calcium—a condition that can shrink and stiffen their blood vessels. In the past, operating on those with calcified b

Most Innovative Companies The world runs on contracts. They’re the basis of uncountable deals and collaborations that allow businesses to thrive and grow. They’re also wildly time-consuming, requiring considerable resources to draft, analyze, organiz

Most Innovative Companies When the pandemic swept through the U.S. in 2020, it decimated many businesses owned by Black, Hispanic, and Native American entrepreneurs. Lockdown measures kept customers, clients, and diners home, putting many businesses

Most Innovative Companies The one-two punch of pandemic related economic disruptions and supply chain issues has rocked the commercial fleet industry and dried up the nation’s vehicle supply chain. But for Merchants Fleet, the past two years have pre

When you walk in, there’s no menu, just a metal riser supporting drinks waiting to be picked up, and in back, some plush banquettes and tables. Display cases are stocked with tidy packs of sushi and sandwiches, and shelves feature gas-station staples