Medical Project

Recommendations (11)


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At a recent meeting, technologists discussed the
increasing frequency of neutron leaking incidents.
Radiation therapy is a conventional means of treating cancer, including
the therapeutic use of photon, electron and proton beams. Neutron
leaking incidents occurred in Taiwanese hospitals in 2003 during the
use of photon beams in radiotherapy. Photoneutron leaking incidents
have become more common in recent years. Patients
undergoing treatment when a neutron leaking incident occurs will not
only invalidate the entire treatment planning process, but also expose
patients and technical personnel to unnecessarily highly radiation
dosages. (NOTE : Add 2-4 sentences that describe characteristics of
the problem or statistics that reflect its severity)
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For instance, determining the different energy
levels when a neutron leaking incident occurs is of priority concern.
According to previous studies, when photon energy exceeds 10MV,
neutrons are produced. While determining the pollution level of
photoneutrons surpassing 10MV, its reduction has seldom been
studied. The inability to reduce the likelihood of
photoneutron leaking incidents makes simulation plans not uniform
during treatment planning, resulting in an improper dosage
administered to the patient and exposing technical personnel to
unnecessarily high radiationlevels. For radiotherapy, tumor dose is
expected as high as possible while sparing the normal tissue dose
surrounded in field. However, the dose of normal tissue out-field is
always out of concern, as an example of photoneutron produced by
high energy x-rays. However, there is no relevant research concerning
about reduction of neutron contamination so far.
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Therefore, we recommend determining the
amount of neutron leaking during photon beam therapy by
using a linear in order to reduce its content and adhere to
the principle of as low as reasonably achievable (ALARA) as
much as possible. To do so, neutron
leaking can be detected using slow-neutron (BF3) detectors,
dual-wall ionization-chamber and thermoluminescent
dosimetes (TLD-600,700). Its material contains lithium-6 or
lithium-7 isotope fluoride, making it possible to undertake
neutron dosimetry. The door of the treatment room can then
be devised with specifications of cement concrete containing
3mm of lead to shield the leakage radiation, scattered
radiation and photoneutron leaking.
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As anticipated, analysis results can be used to
determine the quantity of the photoneutron leakage using the
above methods, making it possible to decrease leakage
levels and increase accuracy in treatment planning.
Moreover, the equivalent dose can also be reduced at the
maze entrance, subsequently reducing costs of neutron
shielding of a lead door. Results of this study
can contribute to efforts to identify neutron contamination
levels in a linear accelerator, enabling Taiwanese hospitals
to enhance treatment quality by administering accurate
dosages during treatment and ensuring patient safety.
(NOTE : Add 2-4 sentences that describe more thoroughly
how the proposed method contributes to a particular field or
sector)
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In our working group meeting last week, we
discussed our hospitals difficulty in increasing cell survival during
cancer treatment. Administering heat shock proteins to
patients experiencing inflammation can increase cell survival and
protect as well as regulate intercellular proteins and proteolysis to
repair damaged proteins. However, inflammation and
fever incur stress involving heavy metals and oxidative stress, leading
to cell death and various diseases, tumors as well as a lower cancer
cell resistance. Before pretreated medicine restrains Ca button,
Lipopolysaccharide(LPS) is used as 5g add RAW264.7 cell line,
resulting in conspicuous inhibitor cell death rate of 80%. The cell is
brought out and Src and Hsp90 subsequently formed to a compound of
50% with LPS behavior. LPS can also be detected and examined,
activating albumens to original form.
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The activation occurs when LPS is
stimulated, with the active increase fivefold of p38 during
15 minutes, in 30 minutes, under with pretreatment, the
activation of p38 , ERK and JNK that LPS brings out is
reduced to a basic value and already existing 30% and
70% in 15 and 30 minutes, respectively.
Although capable of regulating protein functions, HSP
is already proven to be a target of cancer. Breast cancer
may contain HSP 70 and HSP 90 leading to metastasis
and a poor prognosis. Administered medicine can
subsequently decrease the proliferation of cancer cells and
cell death.
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Based on the interaction of HSP antibody and
antigen, we recommend elucidating the role of Hsp90 as a
molecular mechanism that induces LPS-stimulated signaling in
RAW264.7 by using western blotting analysis.
To do so, LPS can be added at different time intervals. Ice-cold
PBS wash cell can then be used to collect eppendroff. Next,
membrane and cytosol of lysis cell can be separated. Additionally,
Western blotting can be performed for several times of appraisal.
As anticipated, analysis results can indicate that a
large number of HSP can be acquired, thus inducing transcription
to eliminate apoptosis. Additionally, LPS can increase HSP as
well. Without the expression of HSP, when human inflammation
and fever occur, cell apoptosis will prove fatal to humans.
Moreover, HSP expression can bind the tumor suppressor
protein, thus enabling the effective control of cancer. (NOTE :
Add 2-4 sentences that describe more thoroughly how the
proposed method contributes to a particular field or sector)
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