MEDICAL HUMAN

FACULTY
National University “Pedro Ruiz Gallo”

6th GROUP: CONTENT

 ALCOSER ARCILA ALFONSO
 DE LA CRUZ RUIZ LENIN  EPIDEMIOLOGY
 LUMBRE YUPTON CÉSAR  ETIOLOGY
 MENDOZA MEGO BORIS  TRANSMITION CYCLE
 QUEVEDO MORI ARTURO  DIAGNOSTIC
 REGALADO ROCHA WILLINTON  SIGNS AND SYMPTOM S
 TREATMENt
 EPIDEMIOLOGY

A. aegypti

Transmitted by Aedes mosquitoes

A. albopictus

The first recognized Dengue epidemics occurred almost simultaneously

in Asia, Africa, and North America in the 1780s

Epidemic dengue has become more common since the 1980s

  By the late 1990s, dengue was the most
important mosquito-borne disease affecting
humans after malaria

 Four different serotypes of dengue

virus

 Dengue hemorrhagic fever is more likely to

occur in patients who have secondary infections by
another one of dengue fever's four serotypes
ANTIBODY-DEPENDENT
ENHANCEMENT (ADE)

Increased uptake and virion replication

Secondary infection with a different strain

 Map showing the distribution of dengue fever in the world, as of 2006. Map
produced by the Agricultural Research Service of the US Department of
Agriculture. Cyan: Areas infested with Aedes aegypti. Red: Areas with Aedes
aegypti and recent epidemic dengue fever.
ETIOLOGY:

•icosahedral capsid Virus Family

Flaviviridae
•genome of
monocatenary RNA

4 serotypes
 CYCLE
REPRODUCTION
DENGUE VIRUS
THE TRANSMISSION CYCLE FOR DENGUE
 THE TRANSMISSION CYCLE FOR DENGUE IS HUMAN - MOSQUITO – HUMAN

(1)The virus is introduced into humans with the mosquito’s saliva

via it’s bite.
(2)The virus stays and spreads in various target organs e.g liver,
lymph nodes
(3)The virus, once released from these tissues spreads in the
white blood cells and other lymphatic tissues
(4)The virus then releases itself form the tissues and circulates in
the blood
(5)A 2nd mosquito ingests the virus in it’s blood
(6)That 2nd mosquito is then inoculated with the virus and therby
affecting it’s salivary glands
(7)The virus replicates in the salivary glands and when this
mosquito bites on an unwilling victim ,the cycle continues …!
 DIAGNOSTIC
AFTER AN INCUBATION PERIOD OF 2-8
DAYS
CLINICALLY, RECOVERY IS
USUALLY

The fever lasts Evidence of plasma Dengue

Bleeding tendency shock
3-5 days leakage
syndrome

PLEURAL HYPOPROTEINEMI
ASCITES
EFFUSION A
 SIGNS AND SYMPTOM S
Patients only transmit Dengue when they are febrile and bitten by
Aedes (Stegomyia) Aegypti mosquitoes

is associated Other manifestations cases of dengue

hemorrhagic
 MANY MANIFESTATIONS

BLEEDING FROM THE EYES ABDOMINAL PAIN

HIGHER FEVER RASH

 A specific treatment

does not exist for the fever

of the fastidiousness.

 You will need liquids if

there are signs of
dehydration.
 The paracetamol (Tylenol)
is in use for treating the high
fever.

 Avoid to take acid

acetilsalicílico (aspirin).
There is no vaccine to
anticipate the fastidiousness.

The best measure of

prevention for residents who
live in areas infected with the
Aedes aegypti.
is to eliminate the places
where the mosquito puts
his eggs, principally the
artificial packings that
accumulate water.
The suitable application
of the repellent, reduce the
risk of being punctured by
the mosquitos
Consult with the doctor if
he has travelled for an area
where it is known that one
presents the fever of the
fastidiousness and if it has
developed symptoms of the
disease.
THANKS FOR YOUR ATTENTION