?

✓
 Hemangioma Melanoma
Leukemia
Carcinoma
Carcinoma
Lymphoma Neurofibroma

Multiple Myeloma Sarcoma

Sarcoma

Papilloma
Schwannomas
Endothelioma
 Osteosarcoma
Fibrosarcoma
Fibrohystiocytic
Ewings Sarcoma
Synovial Sarcoma
Liposarcoma Soft Tissue Sarcoma
Soft Tissue Sarcoma
Rhabdomyosarcoma
Kaposi Sarcoma

Fibroblastic Tumors
 Percentage
Undifferentiate
d Pleiomorphic
Leiomyosarco
ma
37% 23%
Fibrosarcoma

Liposarcoma
14%
2%
4% 15% MPNST
5%
Synovial
DNA

Gene Deletion Gene Mutation Gene Duplication

 Rare disease  Causes problems in:
• Common genetic • Skin
variant • Eyes
 Widevariety in • Brain
symptoms per patient  Cognition
 Cancers
 Epilepsy
• Muscle and Bone
deformities
• Peripheral Cancers
NF1 Mutation NF1

? Early
Neurofibroma

? MPNST

? Metastasis
DNA isolated from
tissue from:
• the blood
• Tumor A
• Tumor B
• Tumor C
PROTEIN DEGRADATION TRANSCRIPTION FACTOR
 Work performed in Dr. Angela Hirbe’s Lab
Washington University in St. Louis

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