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Nutrition Therapy
Types of DM
Type 1(5-10%)
Type 2 (90-95%)
Gestational
Other Specific Types from
specific genetic syndromes
surgery
drugs
Malnutrition (old term)
infections
other illnesses
Impaired glucose tolerance (pre-diabetes)
Types of DM
Characteristic Type 1 DM Type 2 DM
Age of Onset Childhood or Age 40 or older*
adolescence
Rapidness of Onset Usually abrupt Usually gradual
Family history Usually no Common
Etiology Unknown- Unknown-
Heredity,autoimmune, Heredity
viral infections
Body weight Usually thin Obesity common
Endogenous Insulin Very little to none Normal, high, or low
Ketosis Common Uncommon
Symptoms Polyuria/dipsia/phagia Polyuria/dipsia or
and weight loss none
IDDM
Type I DM Type 1 DM
NIDDM
Type II DM Type 2 DM
Diagnostic Criteria
Test
Stage FPG RPG OGTT
Diabetes 126 200 2hPG
plus symptoms
200
Impaired Glucose Impaired Fasting Impaired Glucose
Glucose = Tolerance =
Homeostasis FPG 110 and 2hPG140 and
<126 mg/dl <200 mg/dl
Normal < 110 mg/dl 2hPG <140mg/dl
Predictions
6-8 % of the world population will suffer from
diabetes in the next quarter of a century
300 million people worlwide
Doubling of the prevalence of DM2
to 215 million in the next 15 years
215
250
160
200
Million 150 100
people
100
50
0
1995 2000 2010
DM2
50% not yet diagnosed in Europe & North America!
50
Number in Millions
40
US
30 Europe
China
20 India
10
0
1995 2000 2010 2025
Year
Diabetes: A Worldwide
Epidemic
The Rise in Diabetes: Why?
Increasing longevity.
Change in demographics and genetic
predispositions: the greatest growth of patients
will be in Asia, where it is predicted that by
2010, over 60% of the patients suffering from
diabetes will live in this region of the world.
Rising urbanization and change in lifestyle.
Increase in obesity: over 60% of the adult
population in the United States (and Australia)
are either overweight or obese.
Diabetes: A Worldwide
Epidemic
Percent of Individuals Considered Obese
in a Given Country
2% 15% 25% 50% 70%
25
20
15.5 Control
12.5
15 10.8 Diabetes
10
Mortality
0
10,025 61 6629 279 631 24
(No of patients)
Paris Helsinki
Whitehall
Prospective Study Policemen Study
Study
Macrovascular
coronary artery disease (MI)
cerebrovascular disease (Stroke)
peripheral vascular disease
Microvascular
retinopathy
nephropathy
neuropathy
Diabetes complications
Retinopathy (blindness?)
Nephropathy (kidney problems)
Feet ulceration and/or amputations
Hypertension
Hyperlipidemia (cholesterol?)
Gestational diabetes (during pregnancy)
Diabetes and HIV
Erectile Dysfunction
Diabetes complications
HbA1c relationship with CV
risk
Glycaemia increase Associated risk increase
Stratton IM et al.
al. BMJ 2000; 321: 40512.
Why Treat Diabetes?
DCCT
Diabetes Control and Complications Trial
10-year study in 1441 patients with Type 1 DM
Kumamoto Study
6-year study in 110 Japanese patients with Type 2 DM
UKPDS
United Kingdom Prospective Diabetes Study
20-year study of 5102 newly diagnosed Type 2 DM
The burden of type 2 diabetes can be
reduced
The UKPDS showed that, when glucose levels
are above normal, any reduction in HbA1c is
beneficial
0.9%
= 25%
reduction in HbA1c reduction microvascular
complications
1
The DCCT Group. N Engl. J Med 1993. 2
Ohkubo Y, etl. al. Diab Res Clin Pract 1995.
3
UKPDS Group. Diabetes Care 1998.
Goals of Treatment
Alleviate symptoms
Prevent complications
Prevent progression of current
complications
Improve quality of life
ADA Goals of Treatment (cont.)
A1C
measure of how much hemoglobin has been
glycosylated
represents an average glucose over the last 3
months
Fructosamine
measure of proteins that are glycosylated
represents an average glucose over 2-4 weeks
Diabetic control
Normal HBA1C 3.5 6.5%
Targets
Protein*
Fat*
CHO*
Sucrose and Fructose
Nutritive Sweeteners
Fat Replacements*
Vitamins and Minerals
Alcohol Intake*
Nutrition Goals for
Type 1 *** *** Type
2intake possible
Increase in energy Reduction of energy
essential
Snacks - frequently Snacks - not
necessary recommended
Additional food for Additional food for
exercise - CHO 20 g/h exercise if on
for moderate physical sulfonylurea or insulin
activity
Dietary Management
of Diabetes
Maintain as near-normal blood glucose levels as
possible by balancing food, insulin and exercise
Achieve recommended serum blood lipid levels
Provide energy intake to maintain or attain healthy
weight
Prevent and treat acute and long-term diabetes-related
complications
Enhance over all health
Dietary Intake in US
(NHANES III)
Mean daily intake
2095 Total kcal
34% Fat
15% Protein
50% CHO
2% Alcohol
Macronutrient
Composition of Various
100% 3
Diets 40
15
80%
49 55
70
60% 55
30
40%
34 30
20% 15
30 30
15 15 15
0%
No absolute percentages
CHO and MUFA should be 60-70% kcals
SFA < 10% kcals
Protein intakes of 15-20% kcals
Sample energy distribution
50-60 % CHO
15-20 % Protein
20-30 % Fat
Protein Intake
% Daily Value*
Total Fat 1 g 2%
Saturated Fat 0 g 0%
Cholesterol 0 mg 0%
Sodium 20 mg 1%
Total Carbohydrate 45 g 15%
Dietary Fiber 5 g 20%
Sugars 15 g
Protein 6 g
Vitamin A 0% Vitamin C 0%
Calcium 0% Iron 8%
Starch 80 15 3 0 -1
Fruit 60 15 0 0
Vegetable 25 5 2 0
Lean Meat 55 0 7 3
Fat 45 0 0 5
Starch Group
15 g CHO
1 slice bread (Belgium
30g)
small tortilla
small potato
1/2 cup pasta (60g)
1/2 cup corn (60g)
1/3 cup rice (70g)
3 cups popcorn (180g)
Fruit Group
15 grams CHO
small apple
small orange
17 grapes
1/2 grapefruit
1 cup cantaloupe
3 prunes
4 ounces orange juice (120g)
Milk Group
15 g CHO each
1 cup milk (200ml)
3/4 cup plain yogurt (150g)
1 cup aspartame yogurt (200g)
Vegetable Group
5 grams CHO each
1 cup raw vegis (225g)
1/2 cup cooked vegis (100g)
1/2 cup vegetable juice
(150ml)
Digestion Timing
Peak Post Prandial BG is typically 1-2 hours
after a standard mixed meal.
Liquids (juice/soda) digest quicker.
High fat meals digest slower.
Meal Planning
Set Carbohydrate Intake
specific amount of CHO set to match prescribed
insulin regimen (less flexible)
Adjust Insulin to Desired Carbo Intake
insulin to carbohydrate ratio
1 unit per 10-15 g carbohydrate
1 unit for every 50 mg/dl elevated above target (above
doses may vary)
Insulin Action Times
ketones present.
Use caution with exercise if BG>300 mg/dl,
without ketones.
Eat CHO if BG < 100 mg/dl
Exercise Guidelines: Type 1
DM
Blood Glucose Monitoring
Monitor BG before and after exercise.
Potential Benefits
Improved Glucose tolerance
Weight loss or maintenance or desirable weight
Improved cardiovascular risk factors
Improved response to pharmacologic therapy
Improved energy level, muscular strength,
flexibility, quality of life, and sense of well being
Exercise Prescription
Interest
Capacity
Motivation
Physical status
Individualized approach
Types of exercise
Walking
Biking and stationary cycling
Lap swimming and water aerobics
Weight lifting
At least 3-4 times a week, 30-40 minutes per
session, 50 to 70% of maximum oxygen
uptake
Metabolic Staging of
Type 2 Diabetes
Peripheral
insulin Hyperinsulinemia
resistance
Impaired
glucose Defective glucorecognition
tolerance
Late diabetes
10 5 0 5 10
YEARSFROMDIAGNOSIS
Pre-diabetes
HHS and ADA are using this new term to
describe IFG (impaired fasting glucose) and
IGT (impaired glucose tolerance).
16 million people have pre-diabetes.
Most will develop diabetes within 10 years.
Prevention strategies
screen at risk populations ( > 45 yrs, obese)
lose 5-10% of weight
modest exercise 30 min/day
Weight Control
40% of energy
Saturated fat -- 10% of total energy
Non-nutritive Sweeteners
Aspartame (Equal, Nutrasweet, candarel)
Alcohol
Moderate amounts can be consumed when diabetes
is well controlled
Delayed meals
Eat a snack if expect meal will be delayed
Strenuous exercise
Eat extra food before activity and take 15-30 grams of
CHO for every 30 min of strenuous activity (15 g CHO
for each hour of less strenuous exercise)
Illness
Lack of appetite often with illness
Substitute foods that are well tolerated
Drink sugar containing liquids
For each missed meal give 50 g CHO in small
frequent feedings over 3-4 hours
Type I should not miss insulin as illness often causes
rise in blood glucose
Hypoglycemia: Treatment
Give quickly absorbed CHO immediately (1/3 can coke 33cl, 2
sugar cubes, 15 g glucose tablets)
weight
Healthy BMI
Obesity recognized as an independent risk factor
Physical activity
Increase consumption of complex CHO and
fiber
Amount and type
2000 US Dietary Guidelines
(cont)
Reduce intake of sodium
contribution of ca, mg, K
contribution of obesity
physical activity and alcohol
Consume alcohol in moderation, if at all?
Red wine vs other types of alcohol
2000 US Dietary Guidelines
(cont)
Special Populations:
children
post-menopausal women
elderly
minorities
Populations at increased CVD risk
Elevated LDL-C or pre-existing CVD
Diabetes
Hypertension
Obesity
2000 DGs - Treatment: Obesity and
CVD
Diet Composition Recommendations
Total kcal adequate and appropriate
to prevent weight gain
achieve small, incremental weight losses
provide adequate nutrition, flexibility
Low saturated fat (<10% kcal)
Increase MUS to replace SF
Total Fat < 30% kcal