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Sumadiono
Sumadiono
TORCH INFECTION IN PREGNANT WOMEN and
THE CONSEQUENCIES
Infections Abortus/ Prem. SGA. Anom. Acute dis. Disease
After birth Persistent
Stillbirth
Toksoplasmpsis + + + + + +
Rubella + + + + - +
Cytomegalovirus + + + + + +
Herpes simpleks + + + + + +
Sifilis + + + + + +
In raw meat
From vegetables,
A. Hydrocephalus
A. Hydrocephalus followingfirst-trimester
following first-trimester : Dilated laterallateral
: Dilated ventricles were foundwere
ventricles
during a fetal ultrasonographic survey for a small fetal size for the
found estimatedgestational
during a fetal ultrasonographic
age of 26 weeks. survey for a small fetal size for
the B.
estimatedgestational age of 26
At birth the infant had monocular weeks.
micro-ophthalmia, chorioretinitis, and
blindness,
B. At birth in addition
the infant had to massive hydrocephalus.
monocular micro-ophthalmia, chorioretinitis,
and blindness, in addition to massive hydrocephalus.
C. Brain computed tomographic scan showing small, calcified
lesions.
D. Necrotic lesion adjacentto the lateral ventricle in an infant who
C. Brain computed tomographic scan showing small, calcified lesions.
died from causes
D. Necrotic lesion adjacentto the lateral ventricle in an infant who died from
unrelated
causes to Toxoplasma infection. Toxoplasma tissue cysts
wereidentified into Toxoplasma infection. Toxoplasma tissue cysts wereidentified
unrelated
in
microscopic sections through the lesion.
T US
FE
N T
A
IN F
Rehabilitasi
Mental retardation
Physiotherapy, stimulation, special education, and training
Primary Maternal Primary Maternal
Infection (IgM Antibodi Infection (IgM Antibodi
Rubella) Rubella)
Malformasi Penyakit yg
Cacat & timbul kemudian
penyakit & BBL
Perjalanan Penyakit & Status Imunologi Rubella Kongenital
Rubell
a + + + + + + + - - - -
Virus
infecti
on Maternal IgM IgG
IgG
IgM
1. CRS CONFIRMED:
- Defects present
- & one or more of the following:
a. Rubella virus isolated
b. Rubella-specific immunoglobulin M (IgM) present
c. Infants rubella IgG antibody titer persists above & beyond &
expected from passive transfer of maternal antibody
2.CRS COMPATIBLE laboratory data
insufficient for the confirmation & any two
complications found in list A, or one in A & B.
a.Cataracs & congenital glaucoma (either or
both count as one), congenital heart
disease, loss of hearing, pigmentary
retinophaty)
b.Purpura, splenomegaly, jaundice,
microcephaly, mental retardation,
meningoencephalitis, radiolucent bone
disease.
3.CRS POSSIBLE Some compatible clinical
findings that do not fulfill the criteria for a
compatible case.
4.CONGENITAL RUBELLA INFECTION ONLYNo
defect present but laboratory evidence of
infection.
5.STILL BIRTHSStillbirths which are thought to
be secondary to maternal rubella infection
Infects 50-80% adults < years in USA the virus remains alive
Transmitted to a fetus
Hydrocephal
us
Feto-fetal tranfusion
syndrome
Bronze baby
syndrome
Growth retardation Harlequin
Discordant
twins
Cytomegalovirus
Multiple purpura Cranial CT scan
Hepatosplenomeg - Hydrocephalus
aly - Periventricular calcification
Miliaria
Cutis marmorata
Birth Trauma
Caput succedaneum
Facial Appearance
Infant of diabetic
mother :
macrosomia
Hypoplastic auricle
Low-set ear
Microtia
Physical Examination at the Neonatal Ward
Mouth
Symmetry
Size
Cleft (Labio-palatoschizis)
Teeth
Ranula
Cyst (Epstein,s pearls)
Oral thrush
Oral thrush
Labio-palatoschizis
Macrogloss
ia
Omphalocel
e
Micropenis
Undescensus testis
Ambiguous genitalia
Male (XY) Female (XX)
Testes in Clitoral enlargement
labioscrotal fold
Anal atresia
Rectovaginal
fistula
Dermatitis
Thumb
hypoplasia
Polydactil
y
Sindactily
Post-Term
Long nails, peeling
skin Simian crease
Clubbing of
fingers Sepsis
SCLEREMA
Talipes
equinovarus
Reflex
Grasp
Reflex
Plantar grasp Reflex
Rooting Reflex
Moro Reflex
Paralysis