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Breast Cancer
(T4NBY:
1 M x)
Patrick Kelvian
Sri herlina Dalimunthe
Putri sion ginting
Leonard owen L
0915061
1015132
1015013
1015119
Patient Identity
Name
Age
Gender
MR
Religion
Address
Job
Adm. Date
Room
Pre-op diagnose
Post-op diagnose
Operation
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: Mrs. O
61 years old
Female
168990
Moslem
KarangPawitan
Housewife
25th November 2014 , at : 13.31
: Musa 6-2
Right breast cancer (T4N1Mx)
Right breast cancer (T4N1Mx)
Biopsy Incicion
Anamnesis
Chief Complaint: Lump in right breast
Patient came in with a complaint of a lump inside her
right breast, which has seem to show since the past 5
months. Initially, the lump is felt to be the size of a chicken
egg and has grown ever since. The lump is reddish but no
pain is felt.
By the time the lump is realized, the patient went to
doctor A and had it biopsied. Biopsy was repeated in the
following month and the result from the two previous biopsy
showed that the lump was benign. Two weeks after the
biopsy, patient experienced a secretion of a pus from biopsy
scar, which became more and more and spreading.
Patient complained that the lump has been more
painful in the past two months. Pus comes out from biopsy
scar and spreading. Throbbing pain is experienced until now.
Anamnesis
Treatment/Medical Efforts:
Biopsy at doctor A, 2 times, 5 months ago, and is declared
benign. Visited doctor B and is suggested to run another
biopsy.
Medical History:
Has never experienced such illness before.
Suffered hypertension 10 years ago, took medication
(captopril) and control regularly.
Family Medical History:
No family member has ever had a similar complaint.
History of cancer in family is denied.
History of high blood pressure in family (+).
Anamnesis
History of Allergies:
None in food nor medicine.
History of Habit:
Consumed greasy food, not often exposed to radiation.
Physical Examination
General condition
Sickness degree
Consciousness
Nutrition status
Skin
cyanotic (-)
: Normal
: Moderate
: Compos mentis
: Overweight
: anemic (-),icteric (-),
Vital Sign
Blood pressure
II)
Heart Rate
Respiration Rate
Temperature
General examination
Head
- Eyes: Anemic conj. -/, icteric sclera -/-,
- Pupil: circle, isokor, diameter 3 mm,
pupilary reflex direct +/+, indirect +/+
Neck:
JVP 5+0 cmH20
Chest
: simetrical movement right=left
- Lung : VBS +/+, Rh -/-, Wh -/
- Heart : irregular rhytm, murmur
Abdomen:
Inspection : Flat
Auscultation: Bowel sound (+) normal
Percussion : Tympanic, empty traube space,
CVA - /
Palpation : non palpable liver and spleen
Ascites (-) Pain (-). Murphy sign(-)
Anus
: no examination
Genital
: no examination
General Status
Extremity
: warm, CRT <2, Edema -/ Physiological reflex: +/+
Pathological reflex: -/
Motoric
: normal
Sensoric
: normal
Tremor and involuntary movement (-)
Local Status
Mammae dextra lump 17 cm
x 15 cm, hyperemic with
ulceration, physically stiff,
attached to surrounding
tissue, pressure pain (+),
nipple retraction (-).
Lump at axilla sized 4 cm x
3 cm, phisically stiff,
pressure pain (-).
ECG
(Nov 25th 2014)
Resume
Patient female, 61 years old came in with a complaint of a
lump inside her right breast, which has seem to show since
the past 5 months. Initially, the lump is felt to be the size of
a chicken egg and has grown ever since. The lump is
hyperemic but no pain is felt.
By the time the lump is realized, the patient went to
doctor A and had it biopsied. Biopsy was repeated in the
following month and the result from the two previous biopsy
showed that the lump was benign. Two weeks after the
biopsy, patient experienced a secretion of a pus from
biopsy scar, which became more and more and
spreading.
Patient complained that the lump has been more
painful in the past two months. Pus comes out from biopsy
scar and spreading. Throbbing pain is experienced until now.
Resume
Treatment/Medical Efforts:
Biopsy at doctor A, 2 times, 5 months ago,
and is declared benign. Visited doctor B and is
suggested to run another biopsy.
Medical History:
Suffered hypertension 10 years ago, took
medication (captopril) and control regularly.
Family Medical History:
History of high blood pressure in family (+).
Resume
History of Habit:
Consumed greasy food, not often exposed to
radiation.
Vital Sign
Blood pressure
Heart Rate
Respiration Rate
Temperature
: 190/90 mmHg
: 80 x/mnt, regular
: 20x/mnt
: 36,6C
Local Status
Mammae dextra lump 17 cm
x 15 cm, hyperemic with
ulceration, physically stiff,
attached to surrounding
tissue, pressure pain (+),
nipple retraction (-).
Lump at axilla sized 4 cm x
3 cm, phisically stiff,
pressure pain (-).
Resume
ECG (Nov 25th 2014)
Interpretation : Normal sinus rhytm
Hematology (July 25th 2014)
Hb
: 10.9 g/dl (L)
Ht
: 34 % (L)
Leukocyte
: 13100 /mm3 (H)
USG (Nov 25th 2014)
Result : Normal
Diagnosis pre op
Right Breast Cancer (T4N1Mx)
with
Hypertension stage II
Therapy
Preoperation:
Amoxicilin 3x500 mg
Ketorolac 3x1 amp
Operation (November 26
th
2014)
Diagnosis
Right Breast Cancer (T4N1Mx) (Invasive
ductal right breast cancer grade II)
with
Hypertension stage II
Follow up
Date
Subjective
Objective
Assesment
Work-up
Tuesday
25/11/14
BP : 190/90
Pulse : 80
Temp : 36.6
Respi: 22
Ca mammae
dextra T4N1M0
Inf RL 20/mnt
Amlodipine 1x10 mg
Captopril 3 x 50 mg
Lab
ECG
Chest Xray
USG
Planning for operation
tomorrow if blood pressure
stable (26/11/2014)
Fasting
Wednesday
26/11/14
Operation day
BP : 150/90
Pulse : 80
Temp : 36.7
Respi : 24
Ca mammae
dextra T4N1M0
Infuse RL 20/mnt
Biopsy incision
Thursday
27/11/14
Post op day 1
BP : 170/90
Pulse : 84
Temp : 36.8
Resp : 24
Ca mammae
dextra T4N1M0
Inf RL 20tts/mnt
Amlodipine 1x10 mg
Captopril 3x50 mg
Amoxicilin 3x500mg
Ketorolac 3x1
Prognosis
Quo ad Vitam
: Ad malam
Quo ad Fuctionam
: Ad malam
Quo ad Sanationam : Ad malam
DISCUSSION
Vascularisation
DEFINITION
Cancer isa term used for diseases in which abnormal cells divide
without control and are able to invade other tissues
Ca mammae is a malignant tumor that starts in the cells of the
breast. A malignant tumor is a group of cancer cells that can grow
into (invade) surrounding tissues or spread (metastasize) to distant
areas of the body.
Histopathology Classification
According to WHO dan Japaneese Breast Cancer
Society (1984) Histological Classification of Breast
Tumor
Malignant (Carcinoma)
Non Invasive Carcinoma
Non invasive ductal carcinoma
Lobular carcinoma in situ
Invasive Carcinoma
Invasive ductal carcinoma
Papillobular carcinoma
Solid tubular carcinoma
Scirrhous carcinoma
Grading-based Classification
Grade I
Grade II
Grade III
well-differentiated
moderately differentiated
poorly differentiated
TNM
Classification
Risk Factors
The main risk factor for breast
cancer is hormonal and genetic.
Gender
Age
Age of Menarche
Age when giving first birth
Relatives with breast cancer
Estrogen exposure
How to Diagnose?
Physical diagnosis
X-ray photo
Cytology
Histopathology
Lab check
Supporting Examinations
Ultrasonography
Doppler ultra sound
Mammography
Lab:
Therapy
6 types of standard treatments frequently used:
Surgery
Sentinel lymph node biopsy followed by surgery
Radiation therapy
Chemotherapy
Hormone therapy
Targeted therapy
Surgery
Lumpectomy: a surgery to remove the tumor (lump)
and a small amount of normal tissue around it.
Partial mastectomy: a surgery to remove the breast
that has cancer and some normal tissue around it. The
top layer of the chest muscles below the cancer
infected area may also be removed. This procedure is
also called a segmental mastectomy.
Modified radical
mastectomy: a surgery to
remove the entire breast
that has cancer, along
with lymph nodes under
the arm, upper layer of
the chest muscles, and
sometimes the part of the
chest wall muscles.
Radiation Therapy
Radiation therapy is a cancer treatment that uses
high-energy x-rays or other types of radiation to
destroy cancer cells or keep cancer cells to grow.
There are two types of radiation therapy:
External radiation therapy
Internal radiation therapy
Chemotherapy
Chemotherapy is a cancer treatment that uses
drugs to stop the growth of cancer cells, either by
killing the cells or stopping them from multiplying.
The way the chemotherapy is given depends on
the type and stage of the cancer being treated.
Hormone Therapy
Hormone therapy is a cancer treatment that
removes or blocks hormones tp stop the cancer
cells to grow.
Estrogen, which makes some breast cancers grow,
is produced mainly by the ovaries.
The treatment to stop the ovaries from producing
estrogen is called ovarian ablation.
Targeted Therapy
Targeted therapy is a type of treatment that uses
drugs or other substances to identify and attack
specific cancer cells without harming normal cells.
Staging-Based Therapy
Stage I, Stage II, Stage IIIA, and Stage IIIC Operable
Breast Cancer:
Breast-conserving surgery to remove the cancer and
only some surrounding breast tissue, followed by lymph
node dissection and radiation therapy.
Modified radical mastectomy with or without breast
reconstruction surgery.
Sentinel lymph node biopsy followed by surgery.
Targeted therapy as neoadjuvant therapy (to shrink
tumor before surgery).
Complication
Metastasis
Bleeding
Infection
Prevention
Reduce greasy
food intake
Regular exercise
Prognosis
Major Prognosis factors:
invasive carcinoma or in situ disease
distant metastasis
lymph node metastasis
tumor size
locally advanced disease
inflammatory carcinoma
(American
Joint
histology subtype
grading tumor
estrogen and progesterone receptor
HER2/neu
lymphovascular invasion
proliferative rate
DNA content