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called lymphocytes.
In ALL, the lymphocytes are cancerous and don't fight
infections very well.
These cancerous cells grow quickly and crowd out the
bone marrow, preventing it from making the normal red
blood cells, white blood cells, and platelets that your body
needs.
into remission.
Consolidation:
Uses high doses of intravenous multidrug chemotherapy to
Maintenance therapy:
Aim to kill any residual cell that was not killed by remission
INTRODUCTION TO ALL
PACKAGE:
It is microarray data from 128 different individuals with
COVARIATES OF PHENODATA
Cod: The patient IDs.
Diagnosis date
Gender
Age
BT: The type and stage of the disease.
remission: A factor with two levels, CR or REF.
CR: A vector with the following values: CR, DEATH IN CR,
COVARIATES OF PHENODATA
citog: A vector indicating the various cytogenetic abnormalities that were
detected.
mol.biol : The assigned molecular biology of the cancer BCR\/ABL,
ALL\/AF4, E2APBX etc.
fusion protein: For those with BCR\/ABL which of the fusion proteins
was detected, p190, p190\/p210, p210.
mdr: The patients response to multidrug resistance, either NEG, or POS.
kinet ploidy: either diploid or hyperd.
ccr: A vector indicating whether the patient had continuous complete
remission nor not.
Relapse: A vector indicating whether the patient had relapse or not.
transplant
COVARIATES OF PHENODATA
f.u Follow-up data. The possible values are
1: AUBMT \/ REL: autologous bone marrow transplant and subsequent relapse;
2: BMT \/ CCR: allogeneic bone marrow transplant andstill in continuous complete
remission;
3: BMT \/ DEATH IN CR: after allogeneic bone marrow transplant patient died without
relapsing;
4: BMT \/ REL: after allogeneic bone marrow transplant patient relapsed;
5: CCR: patient was in continuous complete remission;
6: CCR \/ OFF: patient was in continuous complete remission but off-protocol for some
reasons;
7: DEATH IN CR: died when in complete remission;
8: MUD \/ DEATH IN CR: unrelated allogeneic bone marrow transplant and death
without relapsing;
9: REL: relapse; 10: REL \/ SNC: relapse occurred at central nervous system.
METHDODOLOGY
Read PhenoData
Euclidean
Canberra
Distance matrix
Manhatten
Minkowski
Single linkage
Hierarchial clustering
Complete linkage
Average linkage
Complete linkage
Average linkage
Single linkage
Manhattan
0.68
0.69
0.7
Canberra
0.43
0.46
0.46
Minkowski
0.69
0.7
0.6
Euclidean
0.69
0.7
0.6