PRACTICA N 07

PATOLOGIA DE ESOFAGO Y
ESTOMAGO
ASIGNATURA :
CICLO
:
SEMESTRE :
UNIDAD
:
SEMANA
:

PATOLOGIA II
VIII
2016 - II
1ra
7ma
DR. ORLANDO VELASCO VELA
DR. MARIO N. CASTRO RACCHUMI

PATOLOGIA
DE ESOFAGO

An important histologic feature of reflux esophagitis is the elongation of lamina propria papillae to reach
as high as the top 1/3 of the squamous epithelial thickness. Focal surface erosion is also seen at the left
upper corner.

ORGANO
ESOFAGO
TIPO DE LESION
PROCESO INFLAMATORIO
DIAGNOSTICO DE LESION
ESOFAGITIS POR REFLUJO

Below the squamous mucosa is an elongated, inflamed varix.

Hematemesis from variceal bleeding can be massive and difficult to
control.

Inflammation can occur that destroys mucosa and/or submucosa, weakening the
tissues and leading to rupture with hemorrhage as seen here in the region of a
ruptured varix of the esophagus.

ORGANO
ESOFAGO
TIPO DE LESION
TRASTORNO VASCULAR
DIAGNOSTICO DE LESION
VARICES ESOFAGICAS

ORGANO
ESOFAGO
TIPO DE LESION
CAMBIO ADAPTATIVO:METAPLASIA
INTESTINAL
DIAGNOSTICO DE LESION
ESOFAGO DE BARRETT

ORGANO
ESOFAGO
TIPO DE LESION
NEOPLASIA MALIGNA EPITELIAL
GLANDULAR
DIAGNOSTICO DE LESION
ADENOCARCINOMA INFILTRANTE

ORGANO
ESOFAGO
TIPO DE LESION
NEOPLASIA MALIGNA EPITELIAL
DIAGNOSTICO DE LESION
CARCINOMA ESCAMOSO INFILTRANTE

patologia
de
esTOMAGO

ORGANO
ESTOMAGO
TIPO DE LESION
PROCESO INFLAMATORIO
DIAGNOSTICO DE LESION
GASTRITIS CRONICA CON ACTIVIDAD Y
METAPLASIA INTESTINAL POR
HELICOBACTER PILORY

Sharply delimited chronic peptic ulcer with converging folds of

mucosa in the upper half.

El aspecto caracterstico
de una lcera activa que
ha sufrido varias crisis
previas es el siguiente:
el fondo de la lcera est
formado, desde la
superficie a la
profundidad, por las
siguientes capas:
1.Tejido necrtico y
fibrina (N)
2.Polimorfonucleares (I)
3.Tejido granulatorio (G)
4. Tejido conectivo
fibroso.(S)

Chronic peptic ulcer (stomach) is a mucosal defect which penetrates the

muscularis mucosae and muscularis propria, produced by acid-pepsin

Microscopically, the ulcer here is sharply demarcated, with normal

gastric mucosa on the left falling away into a deep ulcer whose base
contains infamed, necrotic debris. An arterial branch at the ulcer

The mucosa at the upper right merges into the ulcer at the left which is eroding through the mucosa.
Ulcers will penetrate over time if they do not heal.
Penetration leads to pain. If the ulcer penetrates through the muscularis and through adventitia, then
the ulcer is said to "perforate" and leads to an acute abdomen. An abdominal radiograph may

The ulcer at the right is penetrating through the muscularis and approaching an artery.
Erosion of the ulcer into the artery will lead to another major complication of ulcersHemorrhage.

Fibrinoid
necrosis
Inflammatory
exudate

Chronic peptic ulcer (stomach).

During the active phase, the
base of the ulcer shows 4
zones :

1.
2.
3.
4.

Fibrinoid necrosis (yellow in van Gieson staining

and pink in H&E)
Inflammatory exudate - at the lumen (cell debris
and neutrophils)
Granulation tissue
Mature fibrous tissue

Tejido necrtico y fibrina

Polimorfonucleares

Tejido granulatorio

Tejido conectivo fibroso

ORGANO
ESTOMAGO
TIPO DE LESION
PROCESO INFLAMATORIO
DIAGNOSTICO DE LESION
ULCERA GASTRICA

ORGANO
ESTOMAGO
TIPO DE LESION
NEOPLASIA MALIGNA EPITELIAL
DIAGNOSTICO DE LESION
ADENOCARCINOMA INFILTRANTE DE
TIPO INTESTINAL

ORGANO
ESTOMAGO
TIPO DE LESION
NEOPLASIA MALIGNA EPITELIAL
DIAGNOSTICO DE LESION
CARCINOMA DE CELULAS EN ANILLO
DE SELLO

Note large lymphocytes (two think arrows) have infiltrated and destroyed a gastric
gland (left arrow). A single mitosis is also seen (arrowhead).

ORGANO
ESTOMAGO
TIPO DE LESION
NEOPLASIA MALIGNA LINFOIDE
DIAGNOSTICO DE LESION
LINFOMA NO HODGKIN DE CELULAS B