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20

The Heart

PowerPoint Lecture Presentations prepared by


Jason LaPres
Lone Star CollegeNorth Harris

2012 Pearson Education, Inc.

An Introduction to the Cardiovascular System


The Pulmonary Circuit
Carries blood to and from gas exchange surfaces of
lungs

The Systemic Circuit


Carries blood to and from the body
Blood alternates between pulmonary circuit and
systemic circuit

2012 Pearson Education, Inc.

An Introduction to the Cardiovascular System


Three Types of Blood Vessels
1. Arteries

Carry blood away from heart

2. Veins

Carry blood to heart

3. Capillaries

Networks between arteries and veins

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An Introduction to the Cardiovascular System


Capillaries
Also called exchange vessels
Exchange materials between blood and tissues
Materials include dissolved gases, nutrients, waste
products

2012 Pearson Education, Inc.

Figure 20-1 An Overview of the Cardiovascular System

PULMONARY CIRCUIT

SYSTEMIC CIRCUIT

Pulmonary arteries

Systemic arteries

Pulmonary veins

Systemic veins

Capillaries
in lungs
Right
atrium
Right
ventricle

Capillaries
in trunk
and lower
limbs
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Capillaries
in head,
neck, upper
limbs
Left
atrium

Left
ventricle

An Introduction to the Cardiovascular System


Four Chambers of the Heart
1. Right atrium

Collects blood from systemic circuit

2. Right ventricle

Pumps blood to pulmonary circuit

3. Left atrium

Collects blood from pulmonary circuit

4. Left ventricle

Pumps blood to systemic circuit

2012 Pearson Education, Inc.

20-1 Anatomy of the Heart


The Heart
Great veins and arteries at the base
Pointed tip is apex
Surrounded by pericardial sac
Sits between two pleural cavities in the mediastinum

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Figure 20-2a The Location of the Heart in the Thoracic Cavity

Trachea

Thyroid gland

First rib (cut)

Base of heart
Left lung

Right lung

Apex of heart
Diaphragm
Parietal pericardium
(cut)

An anterior view of the chest, showing the position of the heart and
major blood vessels relative to the ribs, lungs, and diaphragm.

2012 Pearson Education, Inc.

20-1 Anatomy of the Heart


The Pericardium
Double lining of the pericardial cavity
Visceral pericardium
Inner layer of pericardium

Parietal pericardium
Outer layer
Forms inner layer of pericardial sac

2012 Pearson Education, Inc.

20-1 Anatomy of the Heart


The Pericardium
Pericardial cavity
Is between parietal and visceral layers
Contains pericardial fluid

Pericardial sac
Fibrous tissue
Surrounds and stabilizes heart

2012 Pearson Education, Inc.

Figure 20-2b The Location of the Heart in the Thoracic Cavity

Posterior mediastinum
Esophagus

Aorta (arch segment removed)


Left pulmonary artery

Right pleural cavity


Right
lung

Left
lung

Left pleural cavity

Left pulmonary vein


Bronchus of lung

Right pulmonary artery

Aortic
arch

Right pulmonary vein

Pulmonary trunk
Left atrium
Left ventricle
Pericardial cavity

Superior vena cava

Epicardium

Right atrium

Pericardial sac

Right ventricle
Anterior mediastinum

A superior view of the organs in the mediastinum; portions of the lungs have
been removed to reveal blood vessels and airways. The heart is situated in
the anterior part of the mediastinum, immediately posterior to the sternum.

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Figure 20-2c The Location of the Heart in the Thoracic Cavity

Base of heart
Cut edge of
parietal pericardium
Fibrous tissue of
pericardial sac

Parietal pericardium
Areolar tissue
Mesothelium
Cut edge of epicardium

Wrist (corresponds
to base of heart)
Inner wall (corresponds
to epicardium)
Air space (corresponds
to pericardial cavity)
Outer wall (corresponds
to parietal pericardium)
Balloon

Fibrous
attachment
to diaphragm

Apex of heart

The relationship between the heart and the pericardial cavity; compare with the fist-and-balloon example.

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20-1 Anatomy of the Heart


Superficial Anatomy of the Heart
Atria
Thin-walled
Expandable outer auricle (atrial appendage)

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Figure 20-3a The Superficial Anatomy of the Heart

Left common
carotid artery

Arch of aorta

Brachiocephalic
trunk

Ligamentum
arteriosum
Descending
aorta
Left pulmonary
artery

Ascending
aorta
Superior
vena cava
Auricle
of right
atrium

Pulmonary
trunk
Auricle of
left atrium

RIGHT
ATRIUM
RIGHT
VENTRICLE

Fat and
vessels in
coronary
sulcus

Left subclavian artery

Fat and vessels


in anterior
interventricular
sulcus
LEFT
VENTRICLE

Major anatomical features on the anterior surface.

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Figure 20-3a The Superficial Anatomy of the Heart

Ascending
aorta

Pulmonary
Fibrous
trunk
pericardium

Auricle of
left atrium

Parietal
pericardium
Superior
vena cava

Auricle of
right atrium
RIGHT ATRIUM
Right coronary
artery
Coronary sulcus
RIGHT VENTRICLE
Marginal branch
of right coronary artery
Parietal pericardium
fused to diaphragm
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Anterior
interventricular
sulcus

LEFT
VENTRICLE

Major anatomical features on the anterior surface.

Figure 20-3b The Superficial Anatomy of the Heart

Arch of aorta

Left pulmonary artery


Right pulmonary
artery

Left pulmonary veins


Fat and vessels in
coronary sulcus
Coronary
sinus

Superior
vena cava

LEFT
ATRIUM

RIGHT
ATRIUM

LEFT
VENTRICLE
RIGHT
VENTRICLE

Right
pulmonary
veins (superior
and inferior)

Inferior
vena cava

Fat and vessels in posterior


interventricular sulcus

Major landmarks on the posterior surface. Coronary


arteries (which supply the heart itself) are shown in
red; coronary veins are shown in blue.
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Figure 20-3c The Superficial Anatomy of the Heart

Base of heart

1
Ribs

2
3
4
5
6
7
8
9
10

2
3
4
Apex of
heart

5
6
7
8
9
10

Heart position relative to the rib cage.


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20-1 Anatomy of the Heart


The Heart Wall
1. Epicardium
2. Myocardium
3. Endocardium

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20-1 Anatomy of the Heart


Epicardium (Outer Layer)

Visceral pericardium

Covers the heart

2012 Pearson Education, Inc.

20-1 Anatomy of the Heart


Myocardium (Middle Layer)

Muscular wall of the heart

Concentric layers of cardiac muscle tissue

Atrial myocardium wraps around great vessels

Two divisions of ventricular myocardium

Endocardium (Inner Layer)

Simple squamous epithelium

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Figure 20-4a The Heart Wall

Parietal pericardium
Dense fibrous layer
Areolar tissue
Mesothelium

Pericardial cavity

Myocardium
(cardiac muscle tissue)

Epicardium
(visceral pericardium)

Cardiac muscle cells

Mesothelium

Connective tissues

Areolar tissue

Endocardium
Areolar tissue
Endothelium

2012 Pearson Education, Inc.

Figure 20-4b The Heart Wall

Atrial
musculature

Ventricular
musculature

Cardiac muscle tissue


forms concentric layers
that wrap around the
atria or spiral within the
walls of the ventricles.

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20-1 Anatomy of the Heart


Cardiac Muscle Tissue
Intercalated discs
Interconnect cardiac muscle cells
Secured by desmosomes
Linked by gap junctions
Convey force of contraction
Propagate action potentials

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Figure 20-5a Cardiac Muscle Cells

Cardiac muscle cell


Mitochondria
Intercalated
disc (sectioned)

Nucleus
Cardiac muscle
cell (sectioned)
Bundles of
myofibrils
Intercalated discs

Cardiac muscle cells


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Figure 20-5b Cardiac Muscle Cells

Intercalated disc
Gap junction
Opposing plasma
membranes
Desmosomes

Structure of an intercalated disc

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Figure 20-5c Cardiac Muscle Cells

Intercalated discs

Cardiac muscle tissue

Cardiac muscle tissue

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LM 575

20-1 Anatomy of the Heart


Internal Anatomy and Organization
Interatrial septum separates atria
Interventricular septum separates ventricles

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20-1 Anatomy of the Heart


Internal Anatomy and Organization
Atrioventricular (AV) valves
Connect right atrium to right ventricle and left
atrium to left ventricle
Are folds of fibrous tissue that extend into
openings between atria and ventricles
Permit blood flow in one direction
From atria to ventricles
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20-1 Anatomy of the Heart


The Right Atrium
Superior vena cava
Receives blood from head, neck, upper limbs, and chest

Inferior vena cava


Receives blood from trunk, viscera, and lower limbs

Coronary sinus
Cardiac veins return blood to coronary sinus
Coronary sinus opens into right atrium
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20-1 Anatomy of the Heart


The Right Atrium
Foramen ovale
Before birth, is an opening through interatrial septum
Connects the two atria
Seals off at birth, forming fossa ovalis

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Figure 20-6a The Sectional Anatomy of the Heart

Left common carotid artery


Left subclavian artery

Brachiocephalic
trunk
Superior
vena cava

Ligamentum arteriosum
Pulmonary trunk
Aortic arch
Pulmonary valve

Right
pulmonary
arteries

Left pulmonary
arteries

Ascending aorta
Fossa ovalis
Opening of
coronary sinus

LEFT
ATRIUM

Left pulmonary
veins
Interatrial septum
Aortic valve

RIGHT ATRIUM
Pectinate muscles
Conus arteriosus

Cusp of left AV
(mitral) valve
LEFT VENTRICLE

Cusp of right AV
(tricuspid) valve
Chordae tendineae
Papillary muscles
RIGHT VENTRICLE

Interventricular
septum
Trabeculae
carneae

Inferior vena cava


Moderator band
Descending aorta

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Figure 20-6c The Sectional Anatomy of the Heart

Left coronary artery


branches (red)
and great cardiac
vein (blue)

Ascending aorta
Cusp of aortic valve
Inferior vena cava
Fossa ovalis

Cusp of left AV
(bicuspid) valve

Pectinate muscles

Chordae tendineae

Coronary sinus
RIGHT ATRIUM

Papillary muscles

Cusps of right AV
(tricuspid) valve

LEFT VENTRICLE
Interventricular
septum

Trabeculae carneae
RIGHT VENTRICLE

A frontal section, anterior view.


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20-1 Anatomy of the Heart


The Right Ventricle
Free edges attach to chordae tendineae from
papillary muscles of ventricle
Prevent valve from opening backward
Right atrioventricular (AV) valve
Also called tricuspid valve
Opening from right atrium to right ventricle
Has three cusps
Prevents backflow
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20-1 Anatomy of the Heart


The Right Ventricle
Trabeculae carneae
Muscular ridges on internal surface of right (and left)
ventricle
Includes moderator band
Ridge contains part of conducting system
Coordinates contractions of cardiac muscle cells

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Figure 20-6b The Sectional Anatomy of the Heart

Chordae tendineae
Papillary muscles

The papillary muscles and chordae


tendinae supporting the right AV
(tricuspid) valve. The photograph
was taken from inside the right
ventricle, looking toward a light
shining from the right atrium.
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20-1 Anatomy of the Heart


The Pulmonary Circuit
Conus arteriosus (superior end of right ventricle)
leads to pulmonary trunk
Pulmonary trunk divides into left and right
pulmonary arteries
Blood flows from right ventricle to pulmonary trunk
through pulmonary valve
Pulmonary valve has three semilunar cusps
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20-1 Anatomy of the Heart


The Left Atrium
Blood gathers into left and right pulmonary veins
Pulmonary veins deliver to left atrium
Blood from left atrium passes to left ventricle through
left atrioventricular (AV) valve
A two-cusped bicuspid valve or mitral valve

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20-1 Anatomy of the Heart


The Left Ventricle
Holds same volume as right ventricle
Is larger; muscle is thicker and more powerful
Similar internally to right ventricle but does not have
moderator band

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20-1 Anatomy of the Heart


The Left Ventricle
Systemic circulation
Blood leaves left ventricle through aortic valve
into ascending aorta
Ascending aorta turns (aortic arch) and becomes
descending aorta

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Figure 20-6c The Sectional Anatomy of the Heart

Left coronary artery


branches (red)
and great cardiac
vein (blue)

Ascending aorta
Cusp of aortic valve
Inferior vena cava
Fossa ovalis

Cusp of left AV
(bicuspid) valve

Pectinate muscles

Chordae tendineae

Coronary sinus
RIGHT ATRIUM

Papillary muscles

Cusps of right AV
(tricuspid) valve

LEFT VENTRICLE
Interventricular
septum

Trabeculae carneae
RIGHT VENTRICLE

A frontal section, anterior view.


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20-1 Anatomy of the Heart


Structural Differences between the Left and
Right Ventricles
Right ventricle wall is thinner, develops less pressure
than left ventricle
Right ventricle is pouch-shaped, left ventricle is round

ANIMATION The Heart: Heart Anatomy


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Figure 20-7a Structural Differences between the Left and Right Ventricles

Posterior
interventricular sulcus

Right
ventricle

Left
ventricle

Fat in anterior
interventricular sulcus

A diagrammatic sectional view through the heart,


showing the relative thicknesses of the two ventricles.
Notice the pouchlike shape of the right ventricle and
the greater thickness of the left ventricle.
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Figure 20-7b Structural Differences between the Left and Right Ventricles

Right
ventricle

Left
ventricle

Contracted
Dilated
Diagrammatic views of the ventricles just
before a contraction (dilated) and just after a
contraction (contracted).

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20-1 Anatomy of the Heart


The Heart Valves
Two pairs of one-way valves prevent backflow
during contraction
Atrioventricular (AV) valves
Between atria and ventricles
Blood pressure closes valve cusps during ventricular
contraction
Papillary muscles tense chordae tendineae to prevent
valves from swinging into atria
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20-1 Anatomy of the Heart


The Heart Valves
Semilunar valves
Pulmonary and aortic tricuspid valves
Prevent backflow from pulmonary trunk and aorta
into ventricles
Have no muscular support
Three cusps support like tripod

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Figure 20-8a Valves of the Heart

Transverse Sections, Superior View,


Atria and Vessels Removed
POSTERIOR
Cardiac Left AV (bicuspid)
skeleton
valve (open)

Relaxed ventricles

RIGHT
VENTRICLE

LEFT
VENTRICLE

Right AV
(tricuspid)
valve (open)

Aortic valve
(closed)
ANTERIOR

Aortic valve closed

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Pulmonary
valve (closed)

When the ventricles are relaxed, the AV valves


are open and the semilunar valves are closed.
The chordae tendineae are loose, and the
papillary muscles are relaxed.

Figure 20-8a Valves of the Heart

Frontal Sections through Left Atrium and Ventricle

Relaxed ventricles

Pulmonary
veins
LEFT
ATRIUM
Left AV (bicuspid)
valve (open)

Aortic valve
(closed)

Chordae
tendineae (loose)
Papillary muscles
(relaxed)
LEFT VENTRICLE
(relaxed and filling
with blood)

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Figure 20-8b Valves of the Heart

Contracting ventricles

Cardiac
Right AV
(tricuspid) valve skeleton
(closed)
RIGHT
VENTRICLE

Left AV
(bicuspid) valve
(closed)

LEFT
VENTRICLE

Aortic valve
(open)
Pulmonary
valve (open)

Aortic valve open

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When the ventricles are contracting, the


AV valves are closed and the semilunar
valves are open. In the frontal section
notice the attachment of the left AV valve
to the chordae tendineae and papillary
muscles.

Figure 20-8b Valves of the Heart

Aorta

Contracting ventricles

Aortic sinus
Aortic valve
(open)

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LEFT
ATRIUM
Left AV (bicuspid)
valve (closed)
Chordae tendineae
(tense)
Papillary muscles
(contracted)
Left ventricle
(contracted)

20-1 Anatomy of the Heart


The Blood Supply to the Heart
= Coronary circulation
Supplies blood to muscle tissue of heart
Coronary arteries and cardiac veins

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20-1 Anatomy of the Heart


The Coronary Arteries
Left and right
Originate at aortic sinuses
High blood pressure, elastic rebound forces blood
through coronary arteries between contractions

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20-1 Anatomy of the Heart


Right Coronary Artery
Supplies blood to:

Right atrium

Portions of both ventricles

Cells of sinoatrial (SA) and atrioventricular nodes

Marginal arteries (surface of right ventricle)

Posterior interventricular artery

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20-1 Anatomy of the Heart


Left Coronary Artery
Supplies blood to:
Left ventricle
Left atrium
Interventricular septum

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Figure 20-10 Heart Disease and Heart Attacks

Narrowing of Artery

Normal Artery
Tunica
externa

Lipid deposit
of plaque

Tunica
media
Cross-section

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Cross-section

20-1 Anatomy of the Heart


Heart Disease - Coronary Artery Disease
Coronary artery disease (CAD)
Areas of partial or complete blockage of coronary
circulation

Cardiac muscle cells need a constant supply of


oxygen and nutrients
Reduction in blood flow to heart muscle produces a
corresponding reduction in cardiac performance
Reduced circulatory supply, coronary ischemia,
results from partial or complete blockage of coronary
arteries
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20-1 Anatomy of the Heart


Heart Disease - Coronary Artery Disease
Usual cause is formation of a fatty deposit, or
atherosclerotic plaque, in the wall of a coronary
vessel
The plaque, or an associated thrombus (clot), then
narrows the passageway and reduces blood flow
Spasms in smooth muscles of vessel wall can further
decrease or stop blood flow
One of the first symptoms of CAD is commonly
angina pectoris

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20-1 Anatomy of the Heart


Heart Disease - Coronary Artery Disease
Angina Pectoris
In its most common form, a temporary ischemia
develops when the workload of the heart increases
Although the individual may feel comfortable at rest,
exertion or emotional stress can produce a sensation of
pressure, chest constriction, and pain that may radiate
from the sternal area to the arms, back, and neck

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20-1 Anatomy of the Heart


Heart Disease - Coronary Artery Disease
Myocardial infarction (MI), or heart attack
Part of the coronary circulation becomes blocked, and
cardiac muscle cells die from lack of oxygen
The death of affected tissue creates a nonfunctional
area known as an infarct
Heart attacks most commonly result from severe
coronary artery disease (CAD)

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20-2 The Conducting System


Heartbeat
A single contraction of the heart
The entire heart contracts in series
First the atria
Then the ventricles

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20-2 The Conducting System


Cardiac Physiology
Two Types of Cardiac Muscle Cells
1. Conducting system

Controls and coordinates heartbeat

2. Contractile cells

Produce contractions that propel blood

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20-2 The Conducting System


The Cardiac Cycle
Begins with action potential at SA node
Transmitted through conducting system
Produces action potentials in cardiac muscle cells
(contractile cells)

Electrocardiogram (ECG or EKG)


Electrical events in the cardiac cycle can be recorded
on an electrocardiogram
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20-2 The Conducting System


The Conducting System
A system of specialized cardiac muscle cells
Initiates and distributes electrical impulses that
stimulate contraction

Automaticity
Cardiac muscle tissue contracts automatically

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20-2 The Conducting System


Structures of the Conducting System
Sinoatrial (SA) node - wall of right atrium
Atrioventricular (AV) node - junction between atria
and ventricles
Conducting cells - throughout myocardium

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Figure 20-11a The Conducting System of the Heart

Sinoatrial
(SA) node
Internodal
pathways
Atrioventricular
(AV) node
AV bundle

Bundle
branches
Purkinje
fibers

Components of the conducting


system
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20-2 The Conducting System


Heart Rate
SA node generates 80100 action potentials per
minute
Parasympathetic stimulation slows heart rate
AV node generates 4060 action potentials per
minute

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20-2 The Conducting System


The Sinoatrial (SA) Node
In posterior wall of right atrium
Contains pacemaker cells
Connected to AV node by internodal pathways
Begins atrial activation (Step 1)

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20-2 The Conducting System


The Atrioventricular (AV) Node
In floor of right atrium
Receives impulse from SA node (Step 2)
Delays impulse (Step 3)
Atrial contraction begins

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20-2 The Conducting System


Purkinje Fibers
Distribute impulse through ventricles (Step 5)
Atrial contraction is completed
Ventricular contraction begins

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20-2 The Conducting System


Abnormal Pacemaker Function
Bradycardia - abnormally slow heart rate
Tachycardia - abnormally fast heart rate
Ectopic pacemaker
Abnormal cells
Generate high rate of action potentials
Bypass conducting system
Disrupt ventricular contractions
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20-2 The Conducting System


The Electrocardiogram (ECG or EKG)
A recording of electrical events in the heart
Obtained by electrodes at specific body locations
Abnormal patterns diagnose damage

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20-2 The Conducting System


Features of an ECG
P wave
Atria depolarize

QRS complex
Ventricles depolarize

T wave
Ventricles repolarize

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20-2 The Conducting System


Time Intervals between ECG Waves
PR interval
From start of atrial depolarization
To start of QRS complex

QT interval
From ventricular depolarization
To ventricular repolarization

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Figure 20-13a An Electrocardiogram

Electrode placement for


recording a standard ECG.

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Figure 20-13b An Electrocardiogram

800 msec

P wave
(atria
depolarize)

T wave
(ventricles repolarize)

PR segment

ST
segment

Millivolts
PR
interval

Q S

ST
interval
QT
interval

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QRS interval
(ventricles depolarize)

Figure 20-14 Cardiac Arrhythmias

Premature Atrial Contractions (PACs)


P

Paroxysmal Atrial Tachycardia (PAT)


P

Atrial Fibrillation (AF)

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Figure 20-14 Cardiac Arrhythmias

Premature Ventricular Contractions (PVCs)


P

Ventricular Tachycardia (VT)


P

Ventricular Fibrillation (VF)

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Figure 20-15a The Action Potential in Skeletal and Cardiac Muscle

Rapid Depolarization

The Plateau

Repolarization

Cause: Na entry
Duration: 35 msec
Ends with: Closure of
voltage-gated fast
sodium channels

Cause: Ca2+ entry


Duration: ~175 msec
Ends with: Closure
of slow calcium
channels

Cause: K+ loss
Duration: 75 msec
Ends with: Closure
of slow potassium
channels

mV
Absolute refractory
period

Stimulus

Relative
refractory
period

Time (msec)

Events in an action potential in a ventricular muscle


cell.
KEY
Absolute refractory
period

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Relative refractory
period

20-3 The Cardiac Cycle


The Cardiac Cycle
Is the period between the start of one heartbeat
and the beginning of the next
Includes both contraction and relaxation

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20-3 The Cardiac Cycle

Two Phases of the Cardiac Cycle

Within any one chamber


1. Systole (contraction)
2. Diastole (relaxation)

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Figure 20-16 Phases of the Cardiac Cycle

Start

0
800 msec
msec

100
msec

Cardiac
cycle

370
msec

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20-3 The Cardiac Cycle


Blood Pressure
In any chamber
Rises during systole
Falls during diastole

Blood flows from high to low pressure


Controlled by timing of contractions
Directed by one-way valves

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20-3 The Cardiac Cycle


Cardiac Cycle and Heart Rate
At 75 beats per minute (bpm)
Cardiac cycle lasts about 800 msec

When heart rate increases


All phases of cardiac cycle shorten, particularly diastole

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20-3 The Cardiac Cycle

Phases of the Cardiac Cycle

Atrial systole

Atrial diastole

Ventricular systole

Ventricular diastole

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20-3 The Cardiac Cycle


Atrial Systole
1. Atrial systole
Atrial contraction begins
Right and left AV valves are open
2. Atria eject blood into ventricles
Filling ventricles
3. Atrial systole ends
AV valves close
Ventricles contain maximum blood volume
Known as end-diastolic volume (EDV)
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20-3 The Cardiac Cycle


Ventricular Systole
4. Ventricles contract and build pressure
AV valves close cause isovolumetric contraction

5. Ventricular ejection
Ventricular pressure exceeds vessel pressure opening the
semilunar valves and allowing blood to leave the ventricle
Amount of blood ejected is called the stroke volume (SV)

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20-3 The Cardiac Cycle


Ventricular Systole
6. Ventricular pressure falls
Semilunar valves close
Ventricles contain end-systolic volume (ESV), about 40%
of end-diastolic volume

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Figure 20-17 Pressure and Volume Relationships in the Cardiac Cycle


ATRIAL
ATRIAL
DIASTOLE SYSTOLE
VENTRICULAR
DIASTOLE

ATRIAL DIASTOLE
VENTRICULAR
SYSTOLE

Aortic valve
opens
Aorta

Pressure
(mm Hg)

Atrial contraction begins.


Atria eject blood into ventricles.
Atrial systole ends; AV valves close.
Left
ventricle

Isovolumetric ventricular contraction.


Ventricular ejection occurs.
Semilunar valves close.
Left AV
valve closes

Left atrium

Isovolumetric relaxation occurs.


AV valves open; passive ventricular
filling occurs.

Left
ventricular
volume (mL)

End-diastolic
volume

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Stroke
volume

Time (msec)

20-3 The Cardiac Cycle


Ventricular Diastole
7. Ventricular diastole
Ventricular pressure is higher than atrial pressure
All heart valves are closed
Ventricles relax (isovolumetric relaxation)
8. Atrial pressure is higher than ventricular pressure
AV valves open
Passive atrial filling
Passive ventricular filling

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Figure 20-17 Pressure and Volume Relationships in the Cardiac Cycle


ATRIAL
SYSTOLE

ATRIAL DIASTOLE
VENTRICULAR
SYSTOLE

VENTRICULAR DIASTOLE

Aortic valve
closes

Dicrotic
notch
Atrial contraction begins.
Pressure
(mm Hg)

Atria eject blood into ventricles.


Atrial systole ends; AV valves close.
Isovolumetric ventricular contraction.
Ventricular ejection occurs.
Semilunar valves close.

Left
ventricular
volume (mL)

Left AV
valve opens

End-systolic
volume

Time (msec)

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Isovolumetric relaxation occurs.


AV valves open; passive ventricular
filling occurs.

20-3 The Cardiac Cycle


Heart Sounds
S1
Loud sounds
Produced by AV valves

S2
Loud sounds
Produced by semilunar valves

ANIMATION The Heart: Cardiac Cycle


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20-3 The Cardiac Cycle


S3, S4
Soft sounds
Blood flow into ventricles and atrial contraction

Heart Murmur
Sounds produced by regurgitation through valves

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Figure 20-18a Heart Sounds

Sounds heard
Valve location

Aortic
valve

Valve location
Sounds heard

Pulmonary
valve

Sounds heard
Valve location

Left
AV
valve

Valve location
Sounds heard

Right
AV
valve

Placements of a stethoscope for


listening to the different sounds
produced by individual valves
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Figure 20-18b Heart Sounds

Semilunar
valves close

Pressure
(mm Hg)

Semilunar
valves open

Aort
a

Left
ventricle
Left
atrium

AV valves
open

AV valves
close

S1
S4

S2

Heart sounds
Lubb

S3

Dubb

The relationship between heart sounds and key events in the


cardiac cycle
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S4

Figure 20-21 Autonomic Innervation of the Heart


Vagal nucleus
Cardioinhibitory
center
Cardioacceleratory
center
Medulla
oblongata
Vagus (N X)
Spinal cord

Sympathetic
Sympathetic
ganglia (cervical
ganglia and
superior thoracic
ganglia [T1T4])
Sympathetic
preganglionic
fiber
Sympathetic
postganglionic fiber
Cardiac nerve

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Parasympathetic

Parasympathetic
preganglionic
fiber
Synapses in
cardiac plexus
Parasympathetic
postganglionic
fibers

20-4 Cardiodynamics
Hormonal Effects on Heart Rate
Increase heart rate (by sympathetic stimulation of
SA node)
Epinephrine (E)
Norepinephrine (NE)
Thyroid hormone

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