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The Heart
2. Veins
3. Capillaries
PULMONARY CIRCUIT
SYSTEMIC CIRCUIT
Pulmonary arteries
Systemic arteries
Pulmonary veins
Systemic veins
Capillaries
in lungs
Right
atrium
Right
ventricle
Capillaries
in trunk
and lower
limbs
2012 Pearson Education, Inc.
Capillaries
in head,
neck, upper
limbs
Left
atrium
Left
ventricle
2. Right ventricle
3. Left atrium
4. Left ventricle
Trachea
Thyroid gland
Base of heart
Left lung
Right lung
Apex of heart
Diaphragm
Parietal pericardium
(cut)
An anterior view of the chest, showing the position of the heart and
major blood vessels relative to the ribs, lungs, and diaphragm.
Parietal pericardium
Outer layer
Forms inner layer of pericardial sac
Pericardial sac
Fibrous tissue
Surrounds and stabilizes heart
Posterior mediastinum
Esophagus
Left
lung
Aortic
arch
Pulmonary trunk
Left atrium
Left ventricle
Pericardial cavity
Epicardium
Right atrium
Pericardial sac
Right ventricle
Anterior mediastinum
A superior view of the organs in the mediastinum; portions of the lungs have
been removed to reveal blood vessels and airways. The heart is situated in
the anterior part of the mediastinum, immediately posterior to the sternum.
Base of heart
Cut edge of
parietal pericardium
Fibrous tissue of
pericardial sac
Parietal pericardium
Areolar tissue
Mesothelium
Cut edge of epicardium
Wrist (corresponds
to base of heart)
Inner wall (corresponds
to epicardium)
Air space (corresponds
to pericardial cavity)
Outer wall (corresponds
to parietal pericardium)
Balloon
Fibrous
attachment
to diaphragm
Apex of heart
The relationship between the heart and the pericardial cavity; compare with the fist-and-balloon example.
Left common
carotid artery
Arch of aorta
Brachiocephalic
trunk
Ligamentum
arteriosum
Descending
aorta
Left pulmonary
artery
Ascending
aorta
Superior
vena cava
Auricle
of right
atrium
Pulmonary
trunk
Auricle of
left atrium
RIGHT
ATRIUM
RIGHT
VENTRICLE
Fat and
vessels in
coronary
sulcus
Ascending
aorta
Pulmonary
Fibrous
trunk
pericardium
Auricle of
left atrium
Parietal
pericardium
Superior
vena cava
Auricle of
right atrium
RIGHT ATRIUM
Right coronary
artery
Coronary sulcus
RIGHT VENTRICLE
Marginal branch
of right coronary artery
Parietal pericardium
fused to diaphragm
2012 Pearson Education, Inc.
Anterior
interventricular
sulcus
LEFT
VENTRICLE
Arch of aorta
Superior
vena cava
LEFT
ATRIUM
RIGHT
ATRIUM
LEFT
VENTRICLE
RIGHT
VENTRICLE
Right
pulmonary
veins (superior
and inferior)
Inferior
vena cava
Base of heart
1
Ribs
2
3
4
5
6
7
8
9
10
2
3
4
Apex of
heart
5
6
7
8
9
10
Visceral pericardium
Parietal pericardium
Dense fibrous layer
Areolar tissue
Mesothelium
Pericardial cavity
Myocardium
(cardiac muscle tissue)
Epicardium
(visceral pericardium)
Mesothelium
Connective tissues
Areolar tissue
Endocardium
Areolar tissue
Endothelium
Atrial
musculature
Ventricular
musculature
Nucleus
Cardiac muscle
cell (sectioned)
Bundles of
myofibrils
Intercalated discs
Intercalated disc
Gap junction
Opposing plasma
membranes
Desmosomes
Intercalated discs
LM 575
Coronary sinus
Cardiac veins return blood to coronary sinus
Coronary sinus opens into right atrium
2012 Pearson Education, Inc.
Brachiocephalic
trunk
Superior
vena cava
Ligamentum arteriosum
Pulmonary trunk
Aortic arch
Pulmonary valve
Right
pulmonary
arteries
Left pulmonary
arteries
Ascending aorta
Fossa ovalis
Opening of
coronary sinus
LEFT
ATRIUM
Left pulmonary
veins
Interatrial septum
Aortic valve
RIGHT ATRIUM
Pectinate muscles
Conus arteriosus
Cusp of left AV
(mitral) valve
LEFT VENTRICLE
Cusp of right AV
(tricuspid) valve
Chordae tendineae
Papillary muscles
RIGHT VENTRICLE
Interventricular
septum
Trabeculae
carneae
Ascending aorta
Cusp of aortic valve
Inferior vena cava
Fossa ovalis
Cusp of left AV
(bicuspid) valve
Pectinate muscles
Chordae tendineae
Coronary sinus
RIGHT ATRIUM
Papillary muscles
Cusps of right AV
(tricuspid) valve
LEFT VENTRICLE
Interventricular
septum
Trabeculae carneae
RIGHT VENTRICLE
Chordae tendineae
Papillary muscles
Ascending aorta
Cusp of aortic valve
Inferior vena cava
Fossa ovalis
Cusp of left AV
(bicuspid) valve
Pectinate muscles
Chordae tendineae
Coronary sinus
RIGHT ATRIUM
Papillary muscles
Cusps of right AV
(tricuspid) valve
LEFT VENTRICLE
Interventricular
septum
Trabeculae carneae
RIGHT VENTRICLE
Figure 20-7a Structural Differences between the Left and Right Ventricles
Posterior
interventricular sulcus
Right
ventricle
Left
ventricle
Fat in anterior
interventricular sulcus
Figure 20-7b Structural Differences between the Left and Right Ventricles
Right
ventricle
Left
ventricle
Contracted
Dilated
Diagrammatic views of the ventricles just
before a contraction (dilated) and just after a
contraction (contracted).
Relaxed ventricles
RIGHT
VENTRICLE
LEFT
VENTRICLE
Right AV
(tricuspid)
valve (open)
Aortic valve
(closed)
ANTERIOR
Pulmonary
valve (closed)
Relaxed ventricles
Pulmonary
veins
LEFT
ATRIUM
Left AV (bicuspid)
valve (open)
Aortic valve
(closed)
Chordae
tendineae (loose)
Papillary muscles
(relaxed)
LEFT VENTRICLE
(relaxed and filling
with blood)
Contracting ventricles
Cardiac
Right AV
(tricuspid) valve skeleton
(closed)
RIGHT
VENTRICLE
Left AV
(bicuspid) valve
(closed)
LEFT
VENTRICLE
Aortic valve
(open)
Pulmonary
valve (open)
Aorta
Contracting ventricles
Aortic sinus
Aortic valve
(open)
LEFT
ATRIUM
Left AV (bicuspid)
valve (closed)
Chordae tendineae
(tense)
Papillary muscles
(contracted)
Left ventricle
(contracted)
Right atrium
Narrowing of Artery
Normal Artery
Tunica
externa
Lipid deposit
of plaque
Tunica
media
Cross-section
Cross-section
2. Contractile cells
Automaticity
Cardiac muscle tissue contracts automatically
Sinoatrial
(SA) node
Internodal
pathways
Atrioventricular
(AV) node
AV bundle
Bundle
branches
Purkinje
fibers
QRS complex
Ventricles depolarize
T wave
Ventricles repolarize
QT interval
From ventricular depolarization
To ventricular repolarization
800 msec
P wave
(atria
depolarize)
T wave
(ventricles repolarize)
PR segment
ST
segment
Millivolts
PR
interval
Q S
ST
interval
QT
interval
QRS interval
(ventricles depolarize)
Rapid Depolarization
The Plateau
Repolarization
Cause: Na entry
Duration: 35 msec
Ends with: Closure of
voltage-gated fast
sodium channels
Cause: K+ loss
Duration: 75 msec
Ends with: Closure
of slow potassium
channels
mV
Absolute refractory
period
Stimulus
Relative
refractory
period
Time (msec)
Relative refractory
period
Start
0
800 msec
msec
100
msec
Cardiac
cycle
370
msec
Atrial systole
Atrial diastole
Ventricular systole
Ventricular diastole
5. Ventricular ejection
Ventricular pressure exceeds vessel pressure opening the
semilunar valves and allowing blood to leave the ventricle
Amount of blood ejected is called the stroke volume (SV)
ATRIAL DIASTOLE
VENTRICULAR
SYSTOLE
Aortic valve
opens
Aorta
Pressure
(mm Hg)
Left atrium
Left
ventricular
volume (mL)
End-diastolic
volume
Stroke
volume
Time (msec)
ATRIAL DIASTOLE
VENTRICULAR
SYSTOLE
VENTRICULAR DIASTOLE
Aortic valve
closes
Dicrotic
notch
Atrial contraction begins.
Pressure
(mm Hg)
Left
ventricular
volume (mL)
Left AV
valve opens
End-systolic
volume
Time (msec)
S2
Loud sounds
Produced by semilunar valves
Heart Murmur
Sounds produced by regurgitation through valves
Sounds heard
Valve location
Aortic
valve
Valve location
Sounds heard
Pulmonary
valve
Sounds heard
Valve location
Left
AV
valve
Valve location
Sounds heard
Right
AV
valve
Semilunar
valves close
Pressure
(mm Hg)
Semilunar
valves open
Aort
a
Left
ventricle
Left
atrium
AV valves
open
AV valves
close
S1
S4
S2
Heart sounds
Lubb
S3
Dubb
S4
Sympathetic
Sympathetic
ganglia (cervical
ganglia and
superior thoracic
ganglia [T1T4])
Sympathetic
preganglionic
fiber
Sympathetic
postganglionic fiber
Cardiac nerve
Parasympathetic
Parasympathetic
preganglionic
fiber
Synapses in
cardiac plexus
Parasympathetic
postganglionic
fibers
20-4 Cardiodynamics
Hormonal Effects on Heart Rate
Increase heart rate (by sympathetic stimulation of
SA node)
Epinephrine (E)
Norepinephrine (NE)
Thyroid hormone