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Corticosteroids
for Women at Risk of Preterm
Birth
Ahmed Alaa el din
Introduction
of Action of
Antenatal
Corticosteroi
ds
A. Respiratory Action
B. Circulatory Action
Repeating
antenatal
corticosteroi
ds
The
biologic
rationale
for
repeating
antenatal
corticosteroid therapy is based upon the observation
that biochemical stimulation of surfactant production
appears to be reversible in cell culture models i.e.
surfactant protein mRNA levels decline to control levels
after cortisol is removed.
Effective
Antenatal
Corticosteroi
d Regimens
Corticosteroid Regimens
No
benefits
were
demonstrated
for
treatment
commenced, or infants born, before 26 weeks of
gestation, nor for those born more than seven days after
treatment.
Corticosteroid Regimens
Repeated
Antenatal
Corticosteroi
ds
Advantages
Disadvantages
Disadvantages
Recommend
ations
Recommendations
Thank
you