VIAA I MIRACOLUL

KINETOCORILOR
SINTEZ DIN SANTAGUIDA S.,
MUSACCHIO A. (2009) THE LIFE AND MIRACLES
OF KINETOCHORES.THE EMBO JOURNAL.28:25112531.
ZAMFIR MARIA-ANCA

PREZENTARE GENERAL A FUNCIEI I ORGANIZRII

KINETOCORILOR

Kinetocor de la S. Cerevisiae: centromerul

de 125 bp subdivizat n regiunile CDEI,
CDEII, CDEIII

Cse4: ADN centromeric de aproximativ

125 bp mpachetat n stadiul de
nucleozom

Organizarea centromerilor regionali

i kinetocorilor: domeniul central al
centromerului de la S.pombe conine
2 imr (innermost repeat) i un miez
(core); comparaie S. Pombe i om

Localizarea proteinelor
kinetocorului de-a lungul axului
complexului kinetocormicrotubul la S.cerevisiae n
metafaz i anafaza trzie
Kinetocori adiaceni obinui dintr-o celul aflat n metafaz
prin ngheare rapid i substituire prin ngheare (McEwen i
colab., 1998)

Kinetocor de la
metazoare

D. melanogaster:

localizarea proteinelor
kinetocorului de-a lungul
axului complexului
kinetocor-microtubul (n

Biorientare: ataare
eronat

SPECIFICAREA EPIGENETIC A
CENTROMERILOR

Specificarea epigenetic a cromatinei

centromerice

ATAAREA KINETOCORULUI DE
MICROTUBUL
Ataarea kinetocorului de
microtubul

BIBLIOGRAFIE
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Opin Cell Biol 21: 5158.
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V MULTUMESC PENTRU
ATENIE!