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1. Period of Ag elimination First phase: 90% is removed through the lung, liver & spleen extensive phagocytosis Second phase: gradual catabolic degradation & removal process enzymatic hydrolysis & digestion Third phase: accelerated removal of Ag due to Ab combining w/ Ag, enhances phagocytosis, digestion & removal
Primary Response
First injection of Ag Antigen Route of administration Species of animal Serologic test
Lag of several hours to several days Latent/Induction Few cells Ab finds residual Ag Ab is detected (5th to 10th day) IgM ----IgG
Long-lived cells More Ab production More IgG than IgM (memory cells)
Humoral or Ab response
1. Ab titer: greater in 1. Lag phase delayed secondary response response 2. Time course: shorter lag 2. Log phase increase Ab phase & extended plateau production in 3. Plateau Ab titer is secondary response stabilized 3. Ab class more IgG in 4. Decline Ab is cleared secondary response 4. Ab affinity:greater in secondary response
Cellular Response
1. Describe localized reactions to intracellular microbes 2. Mediated by lymphocytes 3. Occurs after Ag presentation & activation of T cells Activation regulated by T helper & T suppressor 4. Certain T cells release lymphokines activate macrophages 5. Cytotoxic T cells activated by Ag & receive assistance from helper cells to directly kill their target cells 6. Helper T cells also cooperate w/ B cells in the production of Ab, which may arm killer cells carrying Fc receptors 7. NK cells act nonspecifically, particularly against cellular targets
Cellular Response
Cellular Response
Fas system
T cytotoxic cell delivers lethal hit to their target cells via calcium independent mechanism Fas system. TC cell binds to the target cell through the Fas ligand & known to induce apoptosis
ADCC
kill their target cell coated with specific Ab
Macrophages
present the Ag to the T cells during the induction phase & become activated in response to lymphokines during the effector phase