Documentos de Académico
Documentos de Profesional
Documentos de Cultura
1- Droplet infection
Person to person by inhalation aerosols
Mycobacterium tuberculosis (Pulmonary
tuberculosis)
2- Ingestion of milk
Infected cattle
Mycobacterium bovis (Intestinal tuberculosis)
3- Contamination of abrasion
Laboratory workers (Skin infection)
Pathogenesis of
tuberculosis
• infects lung
tuberculosis
• skin testing
– delayed hypersensitivity
– tuberculin
– protein purified
derivative, PPD
• X-ray
Tuberculin Test (Mantoux
test)
Delayed hypersensitivity
skin test to assay:
cell mediated immunity
to tubercle bacillius
Material: A purified
protein derivative (PPD)
Dose : 0.1 ml of (PPD)
is injected intradermal
Reading : Positive test is
defined as
- Induration equal or
greater than 10 mm
- Develop 48-72 hours
after injection
Positive skin test
-tuberculosis
• indicates exposure to
organism
• does not indicate active
disease
Laboratory Diagnosis
Extra -Pulmonary TB –
– Specimen –
CSF – in suspected meningitis
Pleural fluid & other exudates
2-3 days urine in renal TB
Biopsy material.
Treatment
Chemoprophylaxis – INH for one year
Domicilliary treatment preferred
Drugs –
– Rifampicin
– Isoniazide Bactericidal
– Pyrazinamide
– Streptomycin
– Ethambutol
– Ethionamide
– Thiacetazone Bacteriostatic
– Paraminosalicylic acid
– Cycloserine
Treatment
Short term chemotherapy of six
months is sufficient
Problem area – Development of
resistance by mutant selection
– Solution – Treatment by two to three
drug combination, adequate treatment.
Immuno-prophylaxis
Mycobacterium leprae
Classification of Atypical Mycobacteria
Ridley Jopling Classification of Leprosy
Basis - Immunological