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Fluoroquinolones were derived by adding flourine atom in nalidixic acid. They block bacterial DNA synthesis by inhibiting DNA gyrase and topoisomerase IV. They can enter cells easily via porins and are used to treat intracellular pathogens (Legionella, pneumophila and mycoplasma)
Fluoroquinolones were derived by adding flourine atom in nalidixic acid. They block bacterial DNA synthesis by inhibiting DNA gyrase and topoisomerase IV. They can enter cells easily via por…