Kavlevgen 95 141 59 Huddinge Sweden

Phone 08-51774858 Fax 08-318327 E-mail hodrab@mbox.ki.se

Hodjattallah Rabbani
Personal Information Marital status: Married Nationality: Iranian-Swedish Date of Birth: Feb 12, 1960 Place of Birth: Tehran, Iran Personal Number: 600212-1835

Education

1980 - 1984 B. Sc

University of Shahid Beheshty

Tehran

Laboratory Sciences
1985 - 1988 M. Sc Medical science University of Tehran Tehran

Medical Microbiology
1990 - 1997 Ph.D Karolinska Institute, Dept. of Biosciences at NOVU Sweden

Molecular Immunology
Professional experience 1997 - 1999 Researcher 1999 - .. Post-doc position Karolinska Stockholm Hospital, Cancer Center karolins Karolinska Institute, Dept. of Biosciences at NOVU Huddinge

Head of the laboratory at Prof. Hkan Mellstedts group 2004 Associate professor in experimental oncology

Teaching experiences

1988-1990- Medical science University of Tehran As a teacher for medical and paramedical students: Hematology course, 20 hours theory and 20 hours practical teaching Bacteriology course, 20 hours theory and 20 hours practical teaching Bioinformatics Course for teachers in biology Dept. of Biosciences at NOVUM Seminar series, basic immunology dental school Huddinge Hospital Seminar series, immunology Stockholm university 1998 1998 6 hours 2 hours 1996 10 hours

Course: Biotherapy of human malignant disease (nr: 1213) 2000 4 hours

Cancer center Karolinska Course: Neurotransmiters and their receptors-molecular biological techniques Course no: 1490 NOVUM, Hudinge 15 and 19 Oct 2001 3 hours

Organizing Seminar in cDNA Microarray (Affymetrix GeneChip) (Educational) Cancer center Karolinska March 12, 2001 1.5 Hours

From Tumor Immunology to Immune and Gene Therapy of Cancer Cancer center Karolinska Course #1594 October 29, 2002 4.0 Hours Invited seminar, Dept. Hematology, Huddinge Hospital, 2003 2 hours

Course: Neurotransmiters and their receptors-molecular biological techniques Course no: 1490, October 20-24, 2003 NOVUM, Huddinge Course No: 1784 CCK, KS 2004 28 hours 3 hours

Organized course: As course organizer and lecturer From gene to protein (KI Forskarutbildningskurs, 1784) Feb. 2-Feb. 13, 2004, two weeks, two points Nov. 1-Nov. 10, 2004, two weeks, two points Supervising students (Examensarbete) Malin Johansson Parinaz kadkhodayan Jelve Nejaty Annika pontn Malahat mousavy Roberto Danova Johan Lengqvist Amir-Osman Abdalla (Registered) Eva Mikaelsson (Registered) 1991 1994 1994 1995 1996 1997 2000 20 pong 20 pong 20 pong 20 pong 20 pong 4 pong 20 pong

Currently Co-supervising Ph.D students Supervising

Amir Hossein Danesh Manesh (registered as Ph.D student)

Awards received

Diploma as number one in introducing a cancer vaccine strategy together with Prof. Hkan Mellstedt and Anders sterborg (whole group)Venture Cup 99/00, Stockholm, Sweden

Other activities:

Responsible for establishing and maintenance of the following core facilities at CancerCenter Karolinska 1-ELISA system 2-ELISPOT system 3- Real-Time PCR 4- Establishing the Affymetrix GeneChip Array system (CCK, KS)

List of submitted abstracts: 1- L. Hammarstrm, H. Rabbani, A. Bottaro, and CIE Smith The Influence of Gene Duplications in the Human IGH Locus on Serum Levels of Immunoglobulins. 11th European Immunology Meeting, June 10-12, 1991, Helsinki, Finland 2- H. Rabbani, C. I. E. Smith and L. Hammarstrm, Deletions and Duplications in the Human Immunoglobulin Heavy Chain Constant Locus 8th International Congress of Immunology, Budapest, Hungary, 1992 (oral presentation) 3- H. Rabbani, C. I. E. Smith and L. Hammarstrm, Analysis of the Human Ig Heavy Chain Constant Locus by PFGE in Different Ethnic Groups The 9th International congress of immunology, SanFrancisco, USA, 1995 (oral presentation) 4- Pan Q, Rabbani H, Hammarstrm L Switch Region Polymorphism in Patients With IgG3 Subclass Deficiency VII Meeting of the European Society of Immunodeficiencies, ESID June 6-9, 1996, Gteborg, Sweden (Poster) 5- Hodjattallah Rabbani, Qiang Pan, Naomi Kondo, C. I. Edvard Smith and Lennart Hammarstrm. Deletion, Duplication, and Triplication in the Human IGHC Locus in Different Ethnic Groups VII Meeting of the European Society of Immunodeficiencies, ESID June 6-9, 1996, Gteborg, Sweden (Poster and oral presentation) 6- Parviz Kokhaei, Mohammad-Reza Rezvany, Anders sterborg, Hodjattallah Rabbani, and Hkan Mellstedt.
Uptake of Apoptotic Tumor Cell by Autologous Dendritic Cells, A Tool for Immunotherapy in B Cell Malignancies.

11th International Congress of Immunology, Stockholm, Sweden, 2001 7- Fariba Seyed-Mozaffari, Shahryar Kiaii, Anders sterborg, Hodjattallah Rabbani, and Hkan Mellstedt Analysis of T Cell Function in Patients With Chronic Lymphocytic Leukemia. 11th International Congress of Immunology, Stockholm, Sweden, 2001 8- Hodjattallah Rabbani, Fariba Seyed-Mozaffari, Katja Markovic, Jan-Erik Frdin, and Hkan Mellstedt. Immunization of Colorectal Carcinoma Patients With Avipox Vector, Expressing The FullLength Gene of The Ga733/Epcam/Ksa Antigen.

11th International Congress of Immunology, Stockholm, Sweden, 2001 (Poster)

9- H. Mellstedt, L. Henriksson, A. O. Abdalla, H. Rabbani, A. sterborg Combination of the Adjuvant Cytokines GM-CSF and IL-12 With the Idiotype Vaccine Induces a Strong T Cell Immunity and Clinical Effects Might be Obtained. 8th International Myeloma Workshop, May 4-8, 2001, Banff, Canada 10- Shahryar Kiaii, Mahmood Jeddi-Tehrani, Anders sterborg, Hkan Mellstedt, and Hodjattallah Rabbani Utilizing Ki67 Gene Expression for Monitoring T Cell Activation in Vaccination Studies The Society for Biological Therapy's 16th Annual Meeting, November 9-11, 2001 in NIH, Bethesda, USA 11- Hodjattallah Rabbani, Eva Mikaelsson, Amir Hossein Daneshmanesh, Alfred Lppert, Mahmood Jeddi- Tehrani, Mohammad-Reza Rezvany, Ramazan Ali Sharifian, Reza Safaie, Azam Roohi, Anders sterborg, Fazel Shokri, and Hkan Mellstedt Fibromodulin, A Novel Tumor-Associated Antigen Exclusively Expressed in Tumor B-Cells From all Patients with Chronic Lymphocytic Leukemia 8th Congress of the European Hematology Association, 12-15 June, 2003, Lyon, France 12- Eva Mikaelsson, Mahmood Jeddi- Tehrani , Anders sterborg, Fazel Shokri, Hodjattallah Rabbani, Hkan Mellstedt Fibromodulin, A Novel Tumor-Associated Antigen Exclusively Expressed In Tumor B-Cells From Patients With Chronic Lymphocytic Leukemia iwCLL X International Workshop on CLL. Palazzo Dei Congressi Stresa, Lake Maggiore, Italy10-12 October 2003

Papers published in scientific journals

1-37

1. Olsson PG, Rabbani H, Hammarstrom L, Smith CI. Novel human immunoglobulin heavy chain constant region gene deletion haplotypes characterized by pulsed-field electrophoresis. Clin Exp Immunol. 1993;94:84-90 2. Rabbani H, Bottaro A, Carbonara AO, Brusco A, Cariota U, Olsson PG, Smith CI, Hammarstrom L. The influence of gene duplications in the human immunoglobulin heavy chain constant locus on serum levels of immunoglobulin. Immunodeficiency. 1993;4:237-241 3. Rabbani H, de Boer M, Ahlin A, Sundin U, Elinder G, Hammarstrom L, Palmblad J, Smith CI, Roos D. A 40-base-pair duplication in the gp91-phox gene leading to X-linked chronic granulomatous disease. Eur J Haematol. 1993;51:218-222 4. Smith CI, Islam KB, Vorechovsky I, Olerup O, Wallin E, Rabbani H, Baskin B, Hammarstrom L. X-linked agammaglobulinemia and other immunoglobulin deficiencies. Immunol Rev. 1994;138:159-183 5. Ahlin A, De Boer M, Roos D, Leusen J, Smith CI, Sundin U, Rabbani H, Palmblad J, Elinder G. Prevalence, genetics and clinical presentation of chronic granulomatous disease in Sweden. Acta Paediatr. 1995;84:1386-1394 6. Islam KB, Rabbani H, Larsson C, Sanders R, Smith CI. Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk. J Immunol. 1995;154:1265-1272 7. Rabbani H, Kondo N, Smith CI, Hammarstrom L. The influence of gene deletions and duplications within the IGHC locus on serum immunoglobulin subclass levels. Clin Immunol Immunopathol. 1995;76:S214-218 8. Truedsson L, Baskin B, Pan Q, Rabbani H, Vorechovsky I, Smith CI, Hammarstrom L. Genetics of IgA deficiency. Apmis. 1995;103:833-842 9. Rabbani H, Pan Q, Kondo N, Smith CI, Hammarstrom L. Duplications and deletions of the human IGHC locus: evolutionary implications. Immunogenetics. 1996;45:136-141 10. Brown WR, Rabbani H, Butler JE, Hammarstrom L. Characterization of the bovine C alpha gene. Immunology. 1997;91:1-6 11. Mousavi M, Rabbani H, Hammarstrom L. Characterization of the bovine epsilon gene. Immunology. 1997;92:369-373 12. Pan Q, Rabbani H, Mills FC, Severinson E, Hammarstrom L. Allotype-associated variation in the human gamma3 switch region as a basis for differences in IgG3 production. J Immunol. 1997;158:5849-5859 13. Rabbani H, Brown WR, Butler JE, Hammarstrom L. Polymorphism of the IGHG3 gene in cattle. Immunogenetics. 1997;46:326-331

14. Luo L, Lu FM, Hart S, Foroni L, Rabbani H, Hammarstrom L, Yuille MR, Catovsky D, Webster AD, Vorechovsky I. Ataxia-telangiectasia and T-cell leukemias: no evidence for somatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14 bidirectional promoter in T-PLL. Cancer Res. 1998;58:2293-2297 15. Mousavi M, Rabbani H, Pilstrom L, Hammarstrom L. Characterization of the gene for the membrane and secretory form of the IgM heavy-chain constant region gene (C mu) of the cow (Bos taurus). Immunology. 1998;93:581-588 16. Pan Q, Rabbani H, Hammarstrom L. Characterization of human gamma 4 switch region polymorphisms suggests a meiotic recombinational hot spot within the Ig locus: influence of S region length on IgG4 production. J Immunol. 1998;161:3520-3526 17. Rezvany MR, Jeddi-Tehrani M, Rabbani H, Ruden U, Hammarstrom L, Osterborg A, Wigzell H, Mellstedt H. Autologous T lymphocytes recognize the tumour-derived immunoglobulin VH-CDR3 region in patients with B-cell chronic lymphocytic leukaemia. Br J Haematol. 2000;111:230-238 18. Rezvany MR, Jeddi-Tehrani M, Rabbani H, Lewin N, Avila-Carino J, Osterborg A, Wigzell H, Mellstedt H. Autologous T lymphocytes may specifically recognize leukaemic B cells in patients with chronic lymphocytic leukaemia. Br J Haematol. 2000;111:608-617 19. Zhao Y, Rabbani H, Shimizu A, Hammarstrom L. Mapping of the chicken immunoglobulin heavy-chain constant region gene locus reveals an inverted alpha gene upstream of a condensed upsilon gene. Immunology. 2000;101:348-353 20. Brenden N, Rabbani H, Abedi-Valugerdi M. Analysis of mercury-induced immune activation in nonobese diabetic (NOD) mice. Clin Exp Immunol. 2001;125:202-210 21. Rezvany MR, Jeddi-Tehrani M, Biberfeld P, Soderlund J, Mellstedt H, Osterborg A, Rabbani H. Dendritic cells in patients with non-progressive B-chronic lymphocytic leukaemia have a normal functional capability but abnormal cytokine pattern. Br J Haematol. 2001;115:263-271 22. Islam TC, Lindvall J, Wennborg A, Branden LJ, Rabbani H, Smith CI. Expression profiling in transformed human B cells: influence of Btk mutations and comparison to B cell lymphomas using filter and oligonucleotide arrays. Eur J Immunol. 2002;32:982-993 23. Malmberg KJ, Levitsky V, Norell H, de Matos CT, Carlsten M, Schedvins K, Rabbani H, Moretta A, Soderstrom K, Levitskaya J, Kiessling R. IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism. J Clin Invest. 2002;110:1515-1523 24. Mellin H, Dahlgren L, Munck-Wikland E, Lindholm J, Rabbani H, Kalantari M, Dalianis T. Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer. Int J Cancer. 2002;102:152-158 25. Roether S, Rabbani H, Mellstedt H, Abedi-Valugerdi M. Spontaneous downregulation of antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuric chloride is not owing to a general immunosuppression. Scand J Immunol. 2002;55:493-502

26. Zhao Y, Kacskovics I, Pan Q, Liberles DA, Geli J, Davis SK, Rabbani H, Hammarstrom L. Artiodactyl IgD: the missing link. J Immunol. 2002;169:4408-4416 27. Gharagozlou S, Ghods R, Samadi Bahrami Z, Roohi A, Jeddi-Tehrani M, Conti-Fine BM, Sharifian RA, Rabbani H, Shokri F. Characterization of Human Hybridoma Clones Isolated From Hemophilia Patients with Specificity for Different Domains of Coagulating Factor VIII. Hum Antibodies. 2003;12, 3, 67-76 28. Hansson L, Rabbani H, Fagerberg J, Osterborg A, Mellstedt H. T-cell epitopes within the complementarity-determining and framework regions of the tumor derived immunoglobulin heavy chain in multiple myeloma. Blood. 2003;101, 12, 4930-6 29. Kiaii S, Jeddi-Tehrani M, Osterborg A, Mellstedt H, Rabbani H. Utilizing ki67 gene expression for monitoring T cell activation. Immunological methods. 2004;Submitted 30. Kokhaei P, Rezvany R, Virving L, Choudhury A, Rabbani H, Osterborg A, Mellstedt H. Dendritic cells loaded with apoptotic tumour cells induce a stronger T cell response than dendritic cell-tumour hybrids in B-CLL. Leukemia. 2003;17, 5, 894-9 31. Osman Abdalla A, Kiaii S, Hansson L, Rosmann-Dohany E, Jeddi-Tehrani M, Osterborg A, Mellstedt H, Rabbani H. Kinetics of cytokine gene expression in human CD4+ and CD8+ T lypmhocyte subsets using quantitative Real-Time PCR. Scand J Immunol. 2003;58, 6, 6016 32. Ullenhag GJ, Frodin JE, Mosolits S, Kiaii S, Hassan M, Bonnet M, Moingeon P, Mellstedt H, Rabbani H. Immunization of colorectal carcinoma patients with a recombinant canary pox virus expressing the tumor antigen Ep-CAM/KSA (ALVAC-KSA) and GM-CSF induced a tumor-specific cellular immune response. Clin Can Res. 2003;9, 7, 2447-56 33. Zhao Y, Pan Q, Rabbani H, Hammarstrm L. Characterization of the cattle immunoglobulin heavy chain constant region gene locus. J. Biol. Chem. 2003;278, 37, 35024-32 34- Mozaffari, F. Hansson, L. Kiaii, S. Ju, X. Rossmann, E. D. Rabbani, H. Mellstedt, H. Osterborg, A. Signalling molecules and cytokine production in T cells of multiple myelomaincreased abnormalities with advancing stage. Br J Haematol. 2004, 124, 3, 315-324 35- Hansson M, Djerbi M, Rabbani H, Mellstedt H, Gharibdoost F, Hassan M, Depierre JW, Abedi-Valugerdi M. Exposure to mercuric chloride during the induction phase and after the onset of collagen-induced arthritis enhances immune/autoimmune responses and exacerbates the disease in DBA/1 mice, Immunology, 2005, 114, 428437

36- Eva Mikaelsson, Amir Hossein Danesh Manesh, Alfred Lppert, Mahmood JeddiTehrani, Mohammad-Reza Rezvany, Ramazan Ali Sharifian, Reza Safaie, Azam Roohi, Anders sterborg, Hkan Mellstedt, Fazel Shokri and Hodjattallah Rabbani Fibromodulin - an Extracellular Matrix Protein: Characterization of its Unique Gene and Protein Expression in B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Mantle Cell Lymphoma, Blood, 2005, 105, 12, 4828-35

37- Chromek, M. Stankowska, D. Dadfar, E. Kaca, W. Rabbani, H. Brauner, A. Interleukin-8 Response In Cells From The Human Urinary Tract Induced By Lipopolysaccharides Of Proteus Mirabilis O3 And O18, J Urol, 2005, 173, 4, 1381-1384 38- Farah Idali, Maria Wikn1 Jan Wahlstrm1 Hkan Mellstedt3 Anders Eklund, Hodjattallah Rabbani, and Johan Grunewald. Reduced Th1 response in the lungs of HLADR17 positive patients with pulmonary sarcoidosis. Eur Respir J. 2006 Mar;27(3):451-9.

39. Rezvany MR, Jeddi-Tehrani M, Karlsson C, Lundin J, Rabbani H, Osterborg A, Mellstedt H. Reconstitution of the T-cell repertoire following treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with B-cell chronic lymphocytic leukaemia. 40- Amir H. Danesh-Manesh, Eva Mikaelsson, Mahmood Jeddi- Tehrani, Ali Ahmad Bayat, Roya Ghods, Mahyar Ostadkarampour, Mehdi Akhondi, Svetlana Lagercrantz, Catharina Larsson, Anders sterborg, Fazel Shokri, Hkan Mellstedt, and Hodjattallah Rabbani. The Receptor Tyrosine Kinase (RTK) Ror1 is Specifically Expressed and Auto-phosphorylated in B Chronic Lymphocytic Leukemia (B-CLL)- a Novel Structure for Targeted Therapy, 2006, Submitted to Blood!