Documentos de Académico
Documentos de Profesional
Documentos de Cultura
by KT
OVERVIEW
Myasthenia gravis Parkinsonism Epilepsy Multiple sclerosis Normal pressure hydrocephalus Motor neuron disease Muscle disease GBS/CIDP Polyneuropathy, CMT AED+status epilepticus
Myasthenia gravis
Investigation
Tensilon test Ice test Single ber electromyography Repetitive nerve stimulation Ab testing: AChR Ab, Anti-MuSK
RNS
AChR antibodies 80% in generalized MG 55% in Ocular MG Anti-MuSK: orofacial+respiratory, rarely ocular
Drug exacerbating
Curare Penicillamine Botox uoroquinolone, macrolide, aminoglycoside Magnesium
Treatment
anticholinesterase medications thymectomy: thymoma, if no-->generalized, onset<50 immunosuppression plasma exchange IVIG .. S/E: aseptic meningitis, allergic
Exam
25 yo 1 wk 3 PE: bilateral facial palsy, feet and wrist drop, absent DTR treatment?
high dose methylprednisolone high dose broad spectrum ATB plasmapheresis interferon immunosuppressant
CIDP
slowly progressive motor>sensory, hyporeexia 8 weeks Associated: HIV, SLE, MGUS, hepatitis, IBD, lymphoma Tx: IVIg 2g/kg 5 days + Prednisolone
Parkinsonism
Parkinsonism
Parkinsons disease: loss
of
dopaminergic
neurons
of
the
substan4a
nigra Secondary cause: drugs, vascular, NPH Parkinson plus: MSA, PSP, CBD, DLB Neurodegenerative: Wilsons dz, Huntington dz
Hemiballism
large amplitude movement, one side of body proximal muscle Subthalamic nucleus Cause: Stroke, toxoplasma Tx: haloperidol, propanolol, clonazepam
Seizure
Side effects
Side effects
Status epilepticus
Contraception
Drugs decrease efcacy carbamazepine phenytoin phenobarbital topiramate
TIA: ABCD2
Multiple sclerosis
Clinical manifestations
Ancillary symptoms
Heat sensitivity (Uhthoffs symptom) Lhermitte Paroxysmal Trigeminal neuralgia, hemifacial spasm
Investigation
MRI
Treatment
Neuromyelitis optica
ALS
Adrenomyeloneuropathy
over accumulation of very long chain fatty acid (VLCFA) brain, adrenal gland, spinal cord
Kennedy disease
X-linked spinobulbar muscular atrophy mid-adult life androgen insensitivity: gynecomastia, reduced fertility expanded CAG repetition
Myopathy