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10 April 2012

A Newsletter from the Simons Foundation Autism Research Initiative

NEWS Noncoding gene linked to autism Hundreds of genes involved in autism, sequencing studies say IN BRIEF Molecular mechanisms: Autism gene modulates connectivity Clinical research: Gestation period affects autism symptoms Cognition and behavior: Corpus callosum smaller in autism TOOLBOX Researchers map gene expression in the monkey brain BLOG Genetics first Blocking bullies

NEWS

Noncoding gene linked to autism


Researchers have identified a noncoding RNA, a genetic message that is not translated into a protein, that may be involved in autism. The discovery, published 4 April in Science Translational Medicine, came from examining a region on chromosome 5 that has been previously linked to the disorder.

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Hundreds of genes involved in autism, sequencing studies say


The largest set of exome sequencing studies of children with autism and their families to date has identified a handful of genes that may increase risk of the disorder, according to research published in Nature.

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IN BRIEF

Molecular mechanisms: Autism gene modulates connectivity


Neurons lacking PTEN, an autism-associated gene also involved in cancer, are hyperconnected to both near and distant brain cells, according to a study published 1 February in The Journal of Neuroscience.

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Clinical research: Gestation period affects autism symptoms


Both premature and post-term babies develop more severe symptoms of autism than those born close to their due dates, according to a study published 16 March in the Journal of Autism and Developmental Disorders.

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Cognition and behavior: Corpus callosum smaller in autism


Children with autism have a smaller corpus callosum, a bundle of nerve fibers that connects the two hemispheres of the brain, compared with controls, and this difference persists over two years of development, according to a study published 18 February in the Journal of Autism and Developmental Disorders.

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TOOLBOX

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Researchers map gene expression in the monkey brain


Researchers have used gene expression data to create a map of the layers within the neocortex, a brain region involved in sensory perception, motor control and language, of rhesus macaques. The results were published 22 March in Neuron.

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BLOG

Genetics first
Launched in September 2010, the Simons Variation in Individuals Project takes a 'genetics first' approach to the study of autism by studying a large group of people with the same genetic event: deletion or duplication of the 16p11.2 chromosomal region.

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Blocking bullies
Children with autism are bullied three times more than their typically developing siblings, according to research from the Interactive Autism Network.

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