Documentos de Académico
Documentos de Profesional
Documentos de Cultura
Introduction
Drug Information
Resources
Objectives: 1. Describe the attributes and the differences between tertiary, secondary and primary resources 2. Identify the most appropriate resources for a given drug information inquiry and use them effectively. 3. Recognize that primary, secondary and tertiary resources may be available in hard copy, CD-ROM, ON-LINE and/or other Format. 4. Describe how to search computerized data bases.
Tertiary Resource 2
Introduction
professional literatures
Tertiary
Secondary Primary Sources
Tertiary Resource
They are the research studies published in biomedical journals. It is the most current information about drugs. It is not easy job to use journals to answer a drug related question because of its huge growing number (>20000 biomedical journals available)
Tertiary Resource
Primary recourse provides the broad base for development of the rest of the professional literature. It contains original reports of scientific studies on which the knowledge of drugs and therapeutics is built. Current of the information sources, and periodical journals are its most common format. Providing access to the original data from a study as well, having the most current information
Tertiary Resource
They are indexes and abstracts for primary resources. They are valuable tools for quick and selective screening for primary resources. They provide the user with concise tools for gaining access to the primary literatures. Any single indexing or abstracting service can not cover all published articles beside the lag time are the limitations to use secondary resources.
Tertiary Resource
Tertiary Resource
Definition
Tertiary literature is core knowledge established via primary literature or accepted as standard of practice within the medical community.
Tertiary Resource
Introduction
tertiary resources include textbooks, monographs, compendia, handbooks, and published symposia. They represent the condensation of basic facts originally published in the primary literature.
Tertiary Resource
Types
Textbooks On various drug or disease topics
Compendia
A vast array of information about many Drugs such as the physician's desk reference
Full-text databases
Review articles
Advantages
Tertiary resources are the most commonly used sources of information because they are easy to use, concise and compact. Often they provide a review of the literature by an expert in the field. Tertiary references (textbooks, CD-ROMs) are convenient and in general, fairly accessible. Drug information references may be divided into specific subjects to make them easier to use.. Usually the information contained in tertiary literature is well accepted in medical practice.
Tertiary Resource 11
Disadvantages
lag time . outdated even in "new" editions Space limitations within a text may prevent extensive discussion of a drug or topic Authors may emphasize limited information about a topic or drug Authors may present information that is based on a less thorough review of the primary literature
Tertiary Resource
12
Disadvantages (cont.)
It may not be referenced appropriately thus preventing a proper check of the primary literature If the information presented in the tertiary literature is based on flawed primary literature (i.e. Poorly done studies are referenced) then the tertiary information may be suspicious.
Tertiary Resource
13
Disadvantages (cont.)
Any updated or new information cannot be inserted into the printed (hard copy) tertiary literature in a timely fashion. Human bias, error transcription, incorrect interpretation of data and lack of expertise by the author.
Tertiary Resource
14
To assess consistency, compare information presented in one text to the same information presented in another text. Is the reference likely to contain information relevant to the subject being researched? Is the reference clear, concise and easy to use?
Tertiary Resource 16
Tertiary Resource
17
Tertiary Resource
18
General references
Specialized references
Tertiary Resource
19
A. General References
Tertiary Resource
20
General features
1- They are referral books. 2- Their formats are either monographs or monographs plus chapters. 3- Used through their indexes NOT through their contents lists.
Tertiary Resource
21
Textbooks.
Different from the general references in: 1- Their formats are chapters. 2- One can read them from cover to cover. 3- One can use their contents list Not necessary to go to index.
Tertiary Resource
22
Tertiary Resource
23
Tertiary Resource
24
European and investigational drugs Published by the Royal Pharmaceutical Society of Great Britain every 4 years Has a manufacturer directory and index by clinical use (typical European style of indexing) Lists other pharmacopeias the drug is found in.
Tertiary Resource
25
Tertiary Resource
26
Updated monthly (loose-leaf version) Lag time 3 months Arranged by therapeutic class Prescription and OTC listings Helpful summary/comparison tables Contains information about investigational, orphan, and discontinued products and off label uses Not referenced, cumbersome
Tertiary Resource 27
Tertiary Resource
28
Frequently used brand and generic drugs Available at www.merckmedicus.com Annual update Additional information:
Tertiary Resource
29
Tertiary Resource
30
Arranged by AHFS classification number Monographs listed alphabetically Information in monograph: Chemistry, pharmacology, mechanism Dose, administration, pharmacokinetics Drug interactions, preparations, toxicity
Tertiary Resource
31
FDA-approved and off-label uses Published annually with quarterly updates More clinically oriented References are not available in the hard copy but may be available online or with software CD-ROMS Not comprehensive, significant lag time
Tertiary Resource
32
Tertiary Resource
33
Three volumes
I. DRUG Information for the Healthcare Professional II. Drug Information for the Patient (in lay language) III. Legal Requirements
Monographs in alphabetical order in Volume I Published annually Also contains some Canadian drug names Most thorough information on:
Monitoring Adverse drug events
Tertiary Resource 34
Useful Appendices: (typical American style of indexing) Selected List of Drug-Induced Effects Therapeutic Guidelines Poison Control Center Listing Veterinary Medication Classification Excluded Monograph Listing
Tertiary Resource
35
Off-label uses indexed by drug and by indication Not referenced, lag time, only FDA-approved uses, inconvenient to compare agents in the same therapeutic class
Tertiary Resource
36
Tertiary Resource
37
Pocket-sized; PDA & online versions are also available Published annually Drugs listed alphabetically by generic name Useful charts and tables. Specialty versions are available: Pediatric, psychiatric, geriatric Not referenced Lists all reported adverse events but does not always provide the incidence
Tertiary Resource
38
MICROMEDEX
CD-ROM Access information by brand or generic name of drug Referenced, quick and easy to use Expensive, uses other tertiary references Databases available:
DRUGDEX - main drug information database DISEASEDEX - disease states IDENTIDEX - drug identification by imprint code POISINDEX - poisoning and toxicology Martindales foreign drugs
Tertiary Resource 39
Tertiary Resource
40
Updated annually Color pictures and markings for drug identification Has FDA-approved product information only Manufacturers pay to have product information Included Contains section on diagnostics May not contain the complete package insert Not referenced
Tertiary Resource 41
Tertiary Resource
42
Cost data: average wholesale prices (AWP) and NDC numbers. (The National Drug Code) Alphabetical listing of manufacturers with contact information Prescription and OTC products List of drugs that should not be crushed or chewed Published annually with monthly updates
Tertiary Resource
43
B. Specialized References
Tertiary Resource
44
Pharmacotherapy
Tertiary Resource
45
Tertiary Resource
46
Well-written and referenced with helpful tables. Pocket version is available. Focuses on drug therapy, good background information. Also covers non-drug treatment options. Updated edition about every 4 years.
Tertiary Resource
47
Tertiary Resource
48
Well-written with focus on drug therapy. Updated every 4 years. Useful summary tables. Case presentation format, may be more difficult to use as a quick reference.
Tertiary Resource
49
Quick reference with many charts and tables. Updated about every 2 to 3 years.
Tertiary Resource
50
Internal Medicine
Tertiary Resource
51
Gold standard for internal medicine Published every 5 years, referenced Pathophysiology, clinical presentation, diagnosis and treatment guidelines Little drug information & dosing recommendations
Tertiary Resource
52
Used by many healthcare professionals Also includes pediatrics, gynecology, psychiatry, ophthalmology, otolaryngology, dental disorders
Tertiary Resource
53
Tertiary Resource
54
comprehensive and authoritative single-volume textbook of internal medicine. Explains the management of disease, based on an understanding of scientific principles and including the latest developments in treatment. Colour-coded chapters are attractive and make the book easy to navigate. Comprehensive index, clearly displayed, pinpoints information rapidly.
Tertiary Resource 55
Boxes and tables pull out and display important information. Drawings and photographs. Carefully structured headings provide a useful outline for study and quick reference. Gastrointestinal, Rheumatology, Renal, Cardiovascular, Respiratory ,Intensive care medicine, Drug Therapy and poisoning
Tertiary Resource
56
Cardiology
Tertiary Resource
57
Published every 5 years. Good illustrations. Addresses modern-day issues such as medical economics and assessing quality of care. Well-referenced.
Tertiary Resource
58
Organized by condition Comprehensive information on drug therapies and regimens Rapid Interpretation of EKGs (Electrocardiogram (EKG or ECG)) Best guide to learning EKGs User-friendly format.
Tertiary Resource
59
Pediatrics
Tertiary Resource
60
Tertiary Resource
61
Useful pocket guide published every 3 years Has dosing information Electronic version updated annually Four sections: emergency management, diagnostic, formulary, and therapeutic data Some information on pregnancy and lactation Not referenced, not frequently updated, confusing organization, not complete
Tertiary Resource 62
Alphabetical order by generic name Formerly known as Guidelines for Administration of Intravenous Medications to Pediatric Patients Dose, concentration, rate, cautions
Tertiary Resource
63
Pediatric version of the Drug Information Handbook Dose, administration, how supplied, contraindications, adverse effects, drug interactions, antidotes Also contains adult doses May sometimes have information on extemporaneous formulations
Tertiary Resource
64
Pregnancy
Tertiary Resource
65
Excellent reference, gold standard Updated every 4 years Alphabetical by generic name Generic name, class, & pregnancy risk factor Summaries of risk to fetus and risk during breastfeeding Editors assign categories for drugs not classified by the manufacturer Referenced
Tertiary Resource 66
Infectious Diseases
Tertiary Resource
67
Gold standard reference Infection, diagnosis, treatment and useful background information
Tertiary Resource
68
Published annually Pocket-sized and easy to use Includes: dosing in renal impairment, brand & generic names, empiric therapy guidelines, antimicrobial spectra of the agents Not well-referenced
Tertiary Resource
69
Oncology
Tertiary Resource
70
Gold standard, published every 3 to 4 years Pathology, treatment options, & adverse effects Referenced
Tertiary Resource
71
Useful index, introduction on malignancies Pharmacology and use of chemotherapeutic agents Lists investigational drugs and combinations Well-referenced
Tertiary Resource
72
Pharmacology
Tertiary Resource
73
Gold standard pharmacology text Grouped by therapeutic class Mechanism, absorption, distribution, and metabolism Contains review of pharmacokinetics, therapeutics, and toxicology Well-referenced, very thorough Updated every 5 years (infrequent)
Tertiary Resource
74
Drug Interactions
Tertiary Resource
75
Loose-leaf format, updated Introductory chapter discusses mechanisms of interactions Rates significance of interaction and recommends management Referenced Not complete, subjective rating system
Tertiary Resource
76
A typical monograph contains a summary, clinical evidence for the interactions under discussion, the probable mechanism, clinical importance and management Covers interactions between therapeutic drugs, proprietary medicines, herbal medicines, foods, drinks, pesticides and some drugs of abuse
Tertiary Resource
78
Tertiary Resource
79
Tertiary Resource
80
Tertiary Resource
81
Indexed by drug and by adverse event Most comprehensive Published every 4 years with annual updates Contains tables and lists References for some side effects not included Information provided:
May not be complete, references for widely known effects are not included
Tertiary Resource 82
Tertiary Resource
83
Tertiary Resource
84
Gold standard reference Updated every 2 years with annual supplements Drugs organized alphabetically by generic name Information on compatibility and stability with diluents and drugs Solution, Y-site, syringe, and additive compatibility Table format, very useful Not complete, lag time
Tertiary Resource 85
Chart format, loose-leaf Alphabetical listing by generic name May have information not available in Trissels Pages are not numbered
Tertiary Resource
86
IV INDEX
Tertiary Resource
87
Tertiary Resource
88
Helpful for extemporaneous compounding Pharmaceutical calculations, chemistry, radioisotopes New edition every 5 years
Tertiary Resource
89
Merck Index
Chemical name, formula, & structure Physical data, therapeutic category Published every 6 to 10 years
Tertiary Resource
90
Official monographs for preparation and assay of pharmaceutical products Published every 5 years with periodic supplements Information on storage, packaging, labeling, reference standards, & assays USP: drug substances & dosage forms NF: pharmaceutical ingredients Not a very useful reference since most pharmaceuticals are mass-produced
Tertiary Resource 91
Pharmacokinetics
Tertiary Resource
92
Case-study format Includes principles of monitoring therapy, basic pharmacokinetics, & clinical applications Appendix of commonly used equations Mostly theory, little patient integration
Tertiary Resource
93
Published by Applied Therapeutics Most advanced reference More specific drug information than Winters Includes analytical methods and clinical applications
Tertiary Resource
94
Toxicology
Tertiary Resource
95
Poison management guidelines Useful tables and case studies Practice multiple-choice questions
Tertiary Resource
96
gold standard in toxicology field basic concepts and fundamental principles needed to grasp current issues in modern toxicology The text is organized and presented in a logical progression of general principles to specific topics such as organ system toxicology, specific agent toxicology, and environmental toxicology.
Tertiary Resource
97
POISINDEX
Toxicology component of MICROMEDEX Search by brand or generic name Describes what substance looks like, any imprint codes, management of toxicity
Tertiary Resource
98
Toxic Emergencies: Clinics in Emergency Medicine (Clinics in emergency medicine) by William Hanson Current Approaches in Toxicology by Bryan Ballantyne Handbook on the Toxicology of Metals (Hardcover) by Lars Friberg Lars
Tertiary Resource
99
Toxicology of the Eye: by W.Morton Grant. Joel S. Schuman Effects on the Eyes and Visual System from Chemicals, Drugs, Metals and Minerals, Plants, Toxins, and Venoms; Also, Systemic Side Effects from Eye med (Hardcover)
Tertiary Resource
100
Clinical Toxicology of Commercial Products (Hardcover) by Robert E. Gosselin, Roger P. Smith, Harold C Hodge, Jeannet Braddock
Tertiary Resource
101
Drug Identification
Tertiary Resource
102
Tertiary Resource
103
BMJ Publishing, London, United Kingdom. The standard reference for prescribing and dispensing drugs in Britain. Included are notes on the different drug groups to help in the choice of appropriate treatment. The BNF is updated in March and September of each year available on disk and CD-ROM as the Electronic British National Formulary and An electronic web-based format is also available.
Tertiary Resource
104
It is a joint publication of the Saudi pharmaceutical society & Ministry of Health, Riyadh, KSA The standard reference for prescribing and dispensing drugs in Saudi Arabia. Included are notes on the different drug groups to help in the choice of appropriate treatment. The SNF is only one edition published in 1424 H (previous two editions were directory formats). Available as hardcopy only.
Tertiary Resource
105
Having guidelines appendix. Drug interactions appendix. Drug information links appendix. List of community pharmacies all over the kingdom Containing different indexes like: Vendors index. Manufacturers index. Alphabetical drug index Therapeutic index
Tertiary Resource 106
Edited by the Swiss Pharmaceutical Society Alphabetical by generic and brand name Drug name, structure, therapeutic class, synonyms, and manufacturer Cross-referenced by all trade names and substances Not much information is provided
Tertiary Resource
107
Drugs Available Abroad Alphabetical by generic name Drug manufacturer, when it became available, dosage forms, where it is approved Indexed by disease, country of use, drug category Appendices with information on manufacturers and drug regulatory authorities in other countries
Tertiary Resource
108
Non-Prescription Products
Tertiary Resource
109
Format similar to PDR, updated every year Indexed by product name, category, manufacturer, & active ingredient Includes color pictures of products Information: indications, cautions, dose, administration, patient instructions, precautions, how supplied
Tertiary Resource
110
Useful tables and comparisons Includes: Patient assessment and counseling guidelines Pathophysiology and treatment options Dosing, adverse events, & interactions
Tertiary Resource
111
Natural Products
Tertiary Resource
112
Comprehensive and up-to-date information Published by F&C Monthly updates Provides uses, toxicity, & patient info Scientific approach to herbal products
Tertiary Resource
113
Tertiary Resource
114
Tertiary Resource
115
Access Medicine
(http://www.accessmedicine.com/) Collection of textbooks, clinical practice guidelines, news Includes: Goodman & Gilman, Harrisons, Current Medical Diagnosis & Treatment, and the Lange series. Drug monographs (include images, chemical structures, patient education materials) provided by Gold Standard Patient education handouts on common medical problems provided by Postgraduate medicine
Tertiary Resource 116
ClinicalResource@Ovid
(http://clinicalresource.ovid.com/autologin.html) Collection of books, clinical practice guidelines, patient education materials and links to databases Includes: Clin-eguide, Facts and Comparisons and 5Minute Consult series
Tertiary Resource
117
MD Consult
http://home.mdconsult.com/groups/uwash8783.html) Collection of textbooks, journals, drug information, guidelines, patient education handouts, news and updates Drug information and updates from Mosbys drug Consult, package insert information, FDA information Customizable patient handouts diseases and drugs
Tertiary Resource
118
MedlinePlus
(http://medlineplus.gov) NLMs database aimed at consumers for health and wellness information English and Spanish versions as well as large print and audio Includes health topics, drug information, dictionaries, interactive tutorials, directories and links to other resources
Tertiary Resource
119
MedlinePlus
Especially good for quick overview, including statistics, of topics and illustrations Drug information includes MedMaster from ASHP, USP DI Advice for Patients, Natural Standard Online (for natural products) and links to FDA and ClinicalTrials.gov
Tertiary Resource
120
Tertiary Resource
121
Use for detailed information about medications (US and foreign) and natural products as well as exposures to chemicals, toxins and poisonous animals and plants Lengthy bibliographies Instructions for citing under Warranties a& Disclaimers link
Tertiary Resource
122
UpToDate
(http://www.uptodateonline.com/) Evidence-based electronic textbook of medicine Lexi-Interact Drug Interactions program from LexiComp for drug interactions Links from drug names to Lexi-Comp drug information within monographs Provides recommendations for good practice Graphs and tables that may be exported to personal documents
Tertiary Resource 123
Tertiary Resource
124
Tertiary Resource
125
Print version has been gold standard for drug information for years Includes comparison tables for drugs by class or pharmacological action In general, references are included in the Drug Interactions section and in drug class monographs but not in individual drug monographs
Tertiary Resource
126
Tertiary Resource
127
Updated daily Several entry points, e.g. product or common name, scientific name, people use this for, interactions with foods, herbs, dietary supplements, lab tests, diseases or conditions
Tertiary Resource
128