Test No. 6 Q.1.

calculate the HLB of mixture of 40% of span 60&60% tween 60[if HLB of span & tween respectively 5&15] (a)11 (b)15 (c)9 (d)2 Q.2.Type of viscosity official in IP is(a)dynamic viscosity (b)kinetic viscosity Q.3 .Unit of above official viscosity is(a)centipoises/poise (b)stoke & centistokes Q.4. Match the column 1.GLYCERINE2.Flocculated suspension3.NaCMC Solution4.Deflocculated suspension(a)1-C 2-A 3-D 4-B (b) 1-C 2-D 3-A 4-B (c)specific viscosity (c)No unit (d)All (d)A&B

A.--------------------------------------------B---------------------------------------------C----------------------------------------------D----------------------------------------------(c) )1-B 2-C 3-A 4-D (d) )1-C 2-B 3-D 4-A

Q.5-Phenomena of thixotropy charecterised by(a)HighconsistencylowconsistencyHighconsistency (b)LowconsistencyHighconsistencylowconsistency (c) sol to gel stable more rapidly

(d)none

Q.6.Plug flow is most important disadvantage of following type viscometer(a)cup&Bob viscometer (b)falling sphere viscometer (c)Ostwald viscometer (d)Red wood viscometer Q.7.Viscometer used for rheological evaluation of suspension is(a)Rotational viscometer (b)Brook field viscometer (c)Ostwald viscometer (d)All

Q.8.If diameter of capillary viscometer increased 4 times and length increased 4 times,measured viscosity is (a)16 times of original viscosity (b)32 times of original viscosity (c) 8 times of original viscosity (d)2 times of original viscosity Q.9-Creep test is analysed to viscoelastic properties of(a)Emulsion (b)Lotion (c)Ointment (d)Suspension

Q.10-When span,water and mineral oil mixed with continous stirring type of ointment base form(a)W/O TYPE (b)O/W TYPE (c)Mixed emulsion (d) emulsification not possible

Q.11-PROMULGENS is series of non ionic emulsifier composed of mixture of followings(a)cetearyl & stearyl alcohol (b) cetearyl ethoxylate& stearyl ethoxylate (c)cetearyl alcohol & cetaryl ethoxylate (d)All Q.12-Commercial antioxidant used in semisolid is(a)BHT (b)BHA (c)PROPYL GALLATE Q.13-Amaunt of drug in base decreased by following on topical application(a)DMSO (b)Cholines (c)Laurocapram Q.14-Draize test used for evaluation of(a)Wetting agent (b)Skin sensitive (c)Suspending agent (d)All (d)All (d)Skin permeation

Q.15-USP official dissolution apparatus provide flow of dissolution medium with following value of Reynold No.(a)<2000 (b)2000-4000 (c)>40 (d) not depend on RN Q.16. Types of drugs can beused for treanent of angina sympotoms(a)beta blocker (b)Ca++ chnnel blocker (c)nitrates (d)all

Q.17. What are the possible complication that could arise in a patient who has dibetes and start to take beta blocker (a)blocker can mask symptoms of hypoglycemia (b) blocker perfectly safe for patient who have diabetes (c) blocker can mask the symptoms of hyperglycemia (d) none Q.18-which of the following drugs may triggers asthma attacks(a)-blocker (b)NSAIDS (c)-agonist (d)steroids

Q.19.What are the monitering parameters that should be used when treating patient BRETYLIUM for ventricular fibrillation. (a)E.C.G. (b)B.P. (c)H.R. (d)ALL Q.20.Which of the following dosage form of nitroglycerin have the fastest onset of action and longest duration of action respectively. (a) IV drip and transdermal patchs (b)IV drip and buccal tablets (c) buccal tablet and IV drip (d)none . Q.21.Drug used to abort anginal attack(a)GTN (b)ISOSORBIDE DINITRATE (c)NIFEDIPINE (d)A & B . Q.22.Nicorandil is (a)K+ channel opener (b) Na+ channel opener (c) K+channel closer (d) Na+channel closer Q.23.Important action of nitrates to relief of angina is (a) In varient angina-Counter acting coronary spasm (b) In classical angina-Counter acting coronary spasm (c)In varient angina-Action on peripheral vasculature(d) In classical angina-Action on peripheral vasculature Q.24 match the column 1.Diltiazem2.Flunarizine3.Conotoxin4.Nitrates(a)1-A 2-B 3-C 4-D (b) 1-D2-C 3-B 4-A A. Act on L type Ca++ channel B. Act on T type Ca++ channel C. Act on N type Ca++ channel D. Act on Ca++entry. (c) )1-A 2-B 3-D 4-C (d) )1-A 2-C 3-D 4-B (d)ALL. (d) A & B

Q.25 Drug which mainly effect the AV conduction in heart(a)Verapamil (b)Diltiazem (c)Amoldipin Q.26.A Ca++ channel blocker which decreses its own metabolism (a)Verapamil (b)Diltiazem (c)Amoldipin Q.27 Match the column1.Dipyridamol2.Trimetazidine3.Oxopentifyline4.Cromakalin (a)1-C 2-D 3-B 4-A (b) 1-D2-C 3-B 4-A Q.28. Match the column

A.Action antagonized by GLIBENCLAMIDE B.Show rheological proerties C.Uptake inhibitor of adenosine D.Inhibit fatty acid oxidation (c) )1-D 2-C 3-A 4-B (d) )1-D 2-B 3-C 4-A.

1.Procanamide2.Diisopyramide3.Mexilitine4.Propafenone(a)1-C 2-D 3-B 4-A

(b) 1-B2-C 3-D 4-A

A.Na+ channel blocker at open state B.No blocking action C.Quinine like prominrnt cardiac depressant D.Na+ channel blocker at Inactivated state. (c) )1-D 2-C 3-A 4-B (d) )1-D 2-B 3-C 4-A

Q.29.True statement for QUINIDINE except(a)block myocardial Na+ channel at open state (b)block Ca++ channel (c)show blocking action (d)increases digoxin blood level . Q.30.A protective agent used with antacid preparation(a)dimethicone (b)pyroxylon (c)tannic acid (d)all . Q.31.Drug used for treatment of psoriasis except(a)Etretinate (b)coaltar (c) calcitriol (d)ketoconazole . Q.32 Azelaic acid used for the treatment of (a)hyperpigmentation (b)acne vulgaris (c)athletes foot (d)A & B Q.33.Most popular antiseptic and disinfectant for surgical instrument is(a)cetrimide (b)chlorohexidine (c)chlorophores (d)iodophores. Q.34.Choose correct statement for Ca++ channel blocker(a)phenylakylamine bind Ca++channel in resting stage (b)benzothiazepine bind Ca++channel in resting stage (c)dihydropyrimidine bind Ca++ channel in resting stage (d)phenylalkylamine bind Ca++ channel in inactivated stage Q.35.3,4 Dimethoxy phenyl group present in the structure of (a)verapamil (b)diltiazem (c)nefidipine (d)bepridil . Q.36. Above drud metabolism fallow(a)N-DEALKYLATION O- demethylationGC (b) O- demethylation N-DEALKYLATION GC (c) N-oxidation N-demethylation GC (d)N methylation O-oxidation GC Q. 37. Dilteazem is Ca ++ channel have(a)Benzothizipine ring& dimethyl ethy amine group at N of ring (b) Benzothizipine ring&diethyl methyl group at N of ring (c) Benzothiazine ring& dimethyl ethy amine group at N of ring (d) Benzothiazine ring& diethyl methyl amine group at N of ring Q.38.Above drug assay carried by(a)HPLC (b)TLC (c)acid base titration (d)nonaqueous titration Q.39. following group essential for antianginal action of nefidepine(a)Nitro group (b)Nitrate group (c)dimethyl substitution at ring (d)pyrimidinering Q.40. match the columns 1.amoldipineA.2,3dichlorophenyl moiety 2.felodipineB.2-chlorophenyl moiety 3.nicardipineC.benzofuranazyl moiety 4.isradipineD.3-nitrophenyl moiety (a)1-B 2-A 3-D 4-C(b) 1-A2-B 3-D 4-C (c) )1-A 2-B3C 4-D(d) )1-B2-A 3-C4-D Q.41. Tocanide blong to following class of antiarrythmatic drugs(a)1A (b)1B (c)1C (d)2 Q.42. ABOVE drug act through(a)Lenghten RP (b) shorten duration of AP (c)slow conduction (d) all

Q.43.----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Here X&Y respectively is(a)chloroacetoxylidide&[2-diethylamino-N2,6 dimethyphenyl]acetamide (b) chloroxylidide&[2-diethylamino-N2,6 dimethyphenyl]acetamide (c) xyline&[2-diethylamino-N2,6 dimethyphenyl]acetamide (d) chloroacetoxylidide&[2-diethylamino-N2,6 dimethyphenyl]acetamine

Q.44. In above question drug under goses to microsomal oxidation produced active metabolite A, & A under goses to cleavage by amidase produced B & C Metabolite, here A B C isA B C (a) (b) (c) (d) Q.45. PHENOTHIAZINE derivatives used for treatment of arrhythmia is(a)moricizin (b)propafenone (c)chloropromazine (d) loracanide

Q.46. Slect correct statement for sotalol(a)l(-)form show beta blocking& k+channel blocking action (b)not metabolized& not bound to protien (c)d(+)form show k+ channel blocking action (d)all Q.47. naphthol and epichlorhydrin is starting materil for synthesis of(a)propanol (b)naphthalene (c)sotalol Q.48.above drug estimated by(a)by acid base titration (b)by argentometric titration Q.49.slective alpha-1 blocker is(a)none (b)methoxamihe (c) by periodate titration (d)a&b (d)HPLC

(c)yohimbine

(d) phenylephrine

Q.50 steady state mass transfer of drugs across stratum corneum goverened by(a)ficks law 2 (b)a&d (c)none (d)ficks 1 law Q.51.Match the column(1)ALEXANDRA SENNA (2)ALOE BARBADENSIS (3)RHEUM PALMATUM (4)RAMUS PURSHINA (a)1-D 2-C 3-B 4-A (b) 1-D2-B 3-C 4-A (a)phloem fiber is lignified (b)Rossate calcium oxalate crystal (c)Leaf exhibit outer most cutical (d) Clustar sheth and collenchym (c) )1-A 2-C3-B 4-D (d) )1B-2-A 3-C-4-D

Q.52.Which of the following sugar most commonly occurs in GLYCOSIDE (a)-D Glucose (b)-D Gluose (c)-D Galactose (d) -D Mannose Q.53 GLYCOSIDE having following properties EXCEPT (a)Optical activity with levo rotatory effect (b)do not reduse fehling solution (c) crystalline and amorphous substance (d)resin glycoside soluble in water Q.54 ALL GLYCOSIDE contain glucose-o-genin linkage EXCEPT (a)Senna (b)Rhubarb (c)Frengula (d)Cochineal

Q.55 Which of the statement is incorrect for ANTHRAQUINONE (a)Anthranol and Anthrone its reduced form (b) Anthrone is soluble in alkali and Anthranol is insoluble in alkali (c)Anthranol fluorescent in nature and Anthrone non fluorescent in nature (d) Oxanthrone is intermediate between Anthraquinone and Anthranol Q.56 INCORRECT microscopic character of TINNAVELLY SENNA(a)Rubiaceus or paracytic stomata (b)Unicellular conical thick walled warty lignified trichome (c)Leaves are lanceolate and isobilateral (d)cluster sheth and collanchyma Q.57 Main criteria for diffrentation among two specias of senna leaf(a) Leaf contant and palisade ratio (b) Leaf contant and stomatel index (c)palisade ratio and vein islet no. (d)All Q.58 1g of aloe powder is boiled with 10 ml of water and filtered.filterate is treated with borex when few drop of this solution are added n water its gives(a)Green flouresence (b)Sharp pink carmine coloure (c)Wine red colour (d) Cherry red to red pink colour Q.59 In above question test is known as(a)Bromine test (b) Klung isobarbaloin test (c) Nitrous acid test (d) schoenteten reaction

Q.60 Match the column(1)Cassia ovata (a)wider meddulary ray (2)Rhamus californica (b)Papillas cell in epidermis (3)Cassia auriculata (c)Contain angular and inregulr fragment (4)Natol aloe (d) Leaflet show long hair (a)1-A 2-D 3-B 4-C (b) 1-B2-A 3-D 4-C (c) )1-D 2-A3-B 4-C (d) )1-C2-D 3-B 4-A Q.61 PALMIDINE-A is heterodianthrone in nature it formed from(a)Aloe emodine anthrone+ emodine anthrone (b) Aloe emodine anthrone+Chrysophanol anthrone (c) Aloe emodine OXanthrone+Chrysophanol anthrone (d) emodine anthrone+Chrysophanol anthrone Q.62 Calcium oxalate crystal and trichome both are absent in following ANTHRACENE glycoside(a)Aloe barbadensis (b)Cassia acutifolia (c)Rheum emodi (d) Hypericum perforatum Q.63 Synonym and family of obove chosse drug(a)st.john wart and hypericaceae (c)Kumari and liliaceae (b)Radix rhei and polygonaceae (d) Folia senna and leguminaceae

Q.64 ALOE is adulterated with black catechu; pices of iron; stons.Black catechu is detected by(a)Under UV light its gives black colour (b) Under UV light its gives deep brown colour (c) Under UV light its gives green colour (d) colour Under UV light its gives light green colour Q.65 Mathc the column(1)Phenylanine (2)Isolucine (3)Valline (4)Tyrosine (a)1-A 2-B 3-C 4-D (b) 1-C2-D 3-A 4-B (a)Linamarine (b)prunassin (c)Dhurine (d) Lotaustrolin (c) )1-B 2-D3-A 4-C (d) )1-B2-A 3-D 4-C

Q.66 In biosynthesis of glycoside transfer of suger from uridine di phosphate is catalyze by (a)Uridyl transferase (b)Glycosyl transferase (c)Phosphatase transferase (d)Uro glycosyl transferase Q.67 All glycoside synthesize from this strecture EXCEPT (a) (b)

(C)

(d) (d) Acetate unit

Q.68Which of the following is biosynthetic precussor of SARSASAPOGENIN(a)Pregneolone (b)20-22 Di hydroxy Pregneolone (c)Cholesterol

Q.69 Which of the following solvent most commonly used in STAS OTTO METHOD(a)Methanol (b)Benzene (c)Chloroform (d) Ethanol Q.70 Match the column(1)Cyclizine (a)0.025M Potassium iodide (2)Ibuprofen (b)0.1M Cerric ammonium sulphat (3)Nifedipine (c)0.1MAmmonium hydroxide (4)Captopril (d) 0.1M Hydrochloric acid (a)1-D 2-C 3-B 4-A (b) 1-C2-B 3-A 4-D (c) )1-A 2-B3-C 4-D (d) )1-B2-A 3-D 4-C Q.71 Incorrect form of ILKOVIC EQ. is (a) Id=60 (b) (c) (d)Conductivity (d)

Q.72 Polagraphic technique is based on the measurement of(a) Potential diffrance (b)resistance (c)Temperature diffrance

Q.73 Which of the following agent is not used as a polarographic maxima suppressor(a) Triton x 100 (b)Gelatin (c)Dyestaffs (d)None Q.74 Most widely used indicator electrode in polarography is (a)HMDE (b)SCE (c)DME (d) Pool of mercury

Q.75 Match column(1)Migration current (a)directly proportional To conc. Of ions in solutio (2)Convection Current (b) Ferridic Current+Condenser current (3)Diffusion Current (c)Due to the movement of charged partical influence of applied P (4)Residual Current (d) Due to the movement of charged partical by mechinal means (a)1-D 2-C 3-B 4-A(b) 1-C2-D 3-B 4-A (c) )1-A 2-B3-C 4-D(d) )1-D2-C 3-A 4-B Q.76-Brij 96 is(a)poly{oxyethylene(10)oleyl ether} (c)polyoxyethylene stearate (b)sorbiton fatty acid ester (d)Di octyl sodium sulfosuccinate

Q.77-Choose the incorrect variable which used to estimate IVEV Perctaneous absorption (a)Application of medicament (b)Structure of apparatus (c)Measurment of medicament (d)None Q.78-Following statement is/are true abaut enzymes(a)Enzymes are always protien (b)Enzymes are improve the rate of reaction (c)Both A&B (d)Enzymes also have non biological origin Q.79-Mode of enzyme action(a)The catalytic site (b)Proximity and orientation (c)General acid-base reactions (d)All

Q.80-Michaelis Menten constant Km describe the effect of-------------on the enzyme action(a)Only product concentration (b)Only substrate concentration (c)Only temp. (d)All Q.81-Most important feature for the non competitive inhibitors of enzymes is/are(a)Completely destroy the functional group on the enzymes (b)Inhibitors not bind to target enzyme by covlentally/non covalentally (c)Also called poison inhibitors (d)A&C

Q.82-Enzyme CATALASE belongs to class(a)Oxydoreductase (b)Transferases

(c)Hydrolases

(d)Lyases

Q.83-Isoenzymes are(a)Not exist in tissues in two or more form (b)Have same catalytic activity (c)have same same physical,chemical,immunological&electrophoretical activity (d)All Q.84-Enzymes which are useful in the diagnosisof MYOCARDIAL INFARCTION(a)GOT&GPT (b)GOT&PAP (c)CPK&GPT (d)LDH.,GOT&CPK Q.85-Match the columnDisease Diagnostic test A-Brucellosis1-Radial immunodiffusion B-Influenza virus2-Paul bunnet test C-Mononucleosis3-Ducrey test D-Heamophillia4-Coombs test)A-1, (a) B-2,C-3, D-4 (b)A-3,B-4,C-1,D-2 (c)A-4,B-1,C-2,D-3 (d)A-2,B-3,C-4,D-1 Q.86-Following statement is/are true about ELISA(a)No any competitive binding occurs&not similar to RIA (b)Formation of colourless product is basic principle (c)performed by 3 techniques[indirect,sendwitch,competitive] (d) All Q.87-Kahn test is(a)Neutrilization (b)Complement fixtation Q.88-Match the column1-Hydrocarbon type2-Animal/vegitable fat3-Soapbase greases4-Hydrophillic organogel(a)1-C 2-B 3-A 4-D (b) 1-A,2-B 3-C 4-D (c)Tube flocculation test (d)Slide flocculation test

A-Petrolatum B-Lard C-Aluminium stearate D-Carbowax (c) )1-D 2-B,3-C 4-A (d) 1-D,2-C, 3-A, 4-B

Q.89-Match the column1-OzokeriteA-Complex mixtute of semi-solid hydrocarbon 2-CeresinB-Mixture of daturated hydrocarbon 3-PetrolatumC-mixture of ozokerite and paraffin wax 4-Synthetic waxD-Hydrogenated C18 C36 Hydrocarbon chain (a)1-B 2-C 3-A 4-D (b) 1-A,2-B 3-C 4-D (c) )1-B 2-A,3-C 4-D (d) )1-C,2-B, 3-A, 4-D Q.90In semisolid preparations approximate value for min. presentation curve can be estimated by(a)Direct analysis (b)Ultracentrifugation technique (c)Physico-chemical parameter (d)All Q.91- Choose inorrrect one(a)DMSO,DMF,DMA are hygroscopic (c)Anionic>cationic>non ionic[penetration order] (b)Accelerant swell the statutum cornium (d)Surface active agnts alter the chemical state of water

Q.92- Choose inorrrect one (a)D-value implies rate of distruction in product (b)in native removel cream effect on skin is due to stearic effect (c)Pronelgens are non ionic emulsifiers with same MP (d)Dowicil 200 is broad spectrum antimicrobial agent Q.93- Match the column1-Xerorogel2-Hydroel 3-Organogel4-SyneresisA-due to self contaction B-Absance of liquid in gel C-Presence of liquid in gel D-Presence of organic liquid in gel

(a)1-A 2-B 3-D 4-C

(b) 1-B,2-C 3-D 4-A

(c) )1-B 2-C,3-A 4-D (c)Emulsified base

(d) )1-C,2-A, 3-D, 4-B (d)All

Q.94-Hydrophillic petrolatum is an example of(a)Hydrocabon base (b)Emulsifiable base

Q.95-Choose incorrect for suppositories base(a)Acid value<0.2 (b)Saponification value-200-245 (c)Iodine value <7 (d)Curve shoud not be sharp for solid-fat index Q.96-Hydroxyl value in suppositories refers (a)monoglycerides & diglycerides content of fatty base (b)measure esterified position on glyceride molecule (c)mg of KOH that would neutrilised the acetic acid used to acetylate 1 g of fat (d)all . Q.97-Number of peaks in benzeldehyde in NMR spectrum(a)2 (b)3 (c)6 Q.98- Number of peaks in p-nitrotouline in NMR spectrum (a)2 (b)4 (c)3

(d)4 (d)5

Q.99-- Match the column1-Relative viscocityA-ratio of viscocity of the dispersion to that of solvent. 2-Specific viscocity B-relative increase in the visocity of the dispersion over that of solvent. 3-Reduced viscocity C-ratio uf specific viscocity to concentration. 4-Intrensic viscocityD-value of intercept if C=0 in reduced viscocity (a)1-C 2-A 3-D 4-B (b) 1-B,2-A 3-D 4-C (c) )1-A 2-B,3-C 4-D (d) )1-B,2-C, 3-D, 4-A Q.100-- Match the column1-Water no.A-microorganism that are responsible for human disease 2-Harmful microorganismB-lead to deteorioration of the product 3-Objectionable microorganism - C-Produced disease under special environment 4-OppertunisticD-maximum amount of water add in 100 g base (a)1-D 2-C 3-B 4-A (b) 1-D,2-B 3-C 4-B (c) )1-D 2-A,3-B 4-C (d) )1-C,2-A, 3-D, 4-B