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1 Ribograma Introdution 2 Corporate Strategy 3 Business Plan 4 Contact

A.Ferreira-Alemo MD PhD

RIBOGRAMA:

The repeated records of those quantities of free ribosomes, establishes a graphic curve (RIBOGRAMA) that represents the degree of a malignant tendency, which above a certain level of concentration, allows to say that the cells in a tissue (of the colon and rectum, e.g.) can be considered in the process of developing carcinoma in the colonre ctu m mu co sa , b e fo re a n y macroscopic viewing (endoscopy). "

biomolecular basis of the cellular machinery


FREE AND MEMBRANE RIBOSOMES
ROUGH ENDOPLASMIC RETICULUM

RNA

DNA
FREE RIBOSOMES

CELLULAR NUCLEUS

CYTOPLAS M

MEMBRAN E RIBOSOMES

Free ribosomes are generally assumed to synthesize intracellular proteins (internal economy of the cell), whereas bound ribosomes synthesize proteins intended for secretion (exportation)."

biomolecular basis of the cellular machinery


MEMBRANE RIBOSOMES

Schematic three-dimensional rough endoplasmic reticulum, showing the synthesis of proteins destined for export by ribosomes attached to membranes reticulum(signal sequence).!

biomolecular basis of the cellular machinery


CONTROL OF PROTEIN SYNTESIS

Upstream side! !
!

Downstream side!

Tumor Markers!

The protein synthetic capacity of a cell is dictated by a number of processes such:"


mRNA availability;! efciency of translation;! availability of translation factors;" number of ribosomes"

biomolecular basis of the cellular machinery


THE RIBOSOME AS THE COMMON ELEMENT IN THE CELLULAR BIOMOLECULAR PROCESS
1. The evidence accumulated to date indicates that overall the protein synthetic capacity is determined by the number of free ribosomes, which function as an informative sensor of the protein synthesis.! 2. Increased cell proliferation is a hallmark of agressive malignant neoplasms, which requires a general increase in protein synthesis and a specic increase in the synthesis of replication-promoting proteins.!

(Tumor Markers)!

3. Ribosome synthesis, or biogenesis, is a complex process dependent on the coordinated synthesis of approximately 85 ribosomal proteins, four ribosomal RNA (rRNA) and their subsequent processing and assembly into mature ribosomes.!

biomolecular basis of the cellular machinery THE RIBOSOME AS THE COMMON ELEMENT IN THE CELLULAR BIOMOLECULAR PROCESS
CELL CYCLE
FREE RIBOSOMES QUANTITY!
MALIGNANT TRANSFORMED CELL

HYPERPLASIA CELL NORMAL CELL HYPERPLASIA CELL NORMAL CELL

INTERPHASE G1 9,3 S 8,0 Hours" G2 2,0

MITOSIS M 0,7 G1 9,3

INTERPHASE S 8,0 Hours"


PRO 25,2

MITOSIS G2 2,0 M 0,7

It has been shown in polyoma virus-transformed cells that one of the key mechanisms for the loss of control of protein

MET 2,1

ANA 2,1

TEL 12,6

Minutes"

synthesis is an inability to decrease ribosome number, which correlated with proliferation of transformed cells in fresh media without addition of serum growth factors (Stanners et al., 1979).!

biomolecular basis of the cellular machinery

RIBOGRAM CONCEPT
S From the subjective nature, relatively of the amount of free

ribosomes, a diagnosis of malignancy is made just under the idea of the constancy property that consists of an great increase of free ribosomes in cells that are in a process of multiplication without self control, as in the case of malignant cells;"
S A malignant cell

has a very high free ribosomes density that is a fundamental aspect of its phenotype;"

S So, naturally, to describe the quantities of free ribosomes it is

necessary to create a language reproducible, not subjective, with mathematical translation, through a graphic curve that we call RIBOGRAMA."

biomolecular basis of the cellular machinery

RIBOGRAM CONCEPT

biomolecular basis of the cellular machinery

RIBOGRAM CONCEPT

Legend:! smt = every 6 months; A, B, C, D = Concentration levels of free ribosomes"

biomolecular basis of the cellular machinery

RIBOGRAM CONCEPT

STA

TICS TIS

The RIBOGRAMA method can represent a brandnew generation of " molecular biomarker for use in very early diagnosis, and even to orientate the therapeutic, helping the drug testing for treatments like ADC (Antibody Drug Conjugates), in the same fashion of the antibiograme."

COLORECTAL CANCER (CRC)

PREPARATION AND COUNTING OF FREE RIBOSOMES

RIBOGRAMA is an objective and quantitative method that provides an unique service to HealthCare Providers worldwide. The method is qualied to deal within all business sectors of the worldwide HealthCare, from the sole practice physician to the largest chain of hospitals. " "
"

The advantages of RIBOGRAMA METHOD over other noninvasive tests of cancer of the colon and rectum are the evident twelve "factors nice" that by themselves provide a good patient compliance and a preference for determining the health professionals, because there are no false positives or false negatives, since they are considering charges of ribosomes of cells isolated from the colorectal mucosa."

The colorectal cancer represents one of the biggest incidences of human cancer in the western type of life and cocked food. " " This research project has strong potential in the following elds :" public health, " medico-hospitalar practice," clinical and laboratorial research, " food industry," veterinary, " oncologic research, " pharmaceutical industry and " clinical trials research etc., " The method has great medical and nancial impact, rstly, by now, in the lowering signicantly the morbidity and mortality of the colorectal cancer disease, in the world, and, after, with other organs and systems.!

To be the leading independent Cancer research Lab in Portugal

To be a caring pharmaceutical company helping to enhance health trough quality products

To build a Portuguese recognized brand

kept and maintained in spite of the difficulties it went through, a framework of high quality human resources, which has allowed it to continue to produce and actively work towards the goal of meeting all the requirements of APIFARMA pro forma to ensure the achievement of Best Practices Manufacturing.
Quality assurance - a pharmacist Regulatory Affairs - a pharmacist Head coach - a pharmacist Quality control - a pharmacist and a chemical engineer Microbiology - a biologist Administrative Services - a receptionist / secretary, an accountant, 1 billing clerk Production - 10 employees Others - two helpers for cleaning, a doorman, a maintenance operator Directors - 4 directors

Ribograma

27 

Because aspire to both understand & improve how research is undertaken" Particularly interested in how the few inuence the many to accomplish bold goals"
Cancer research Lab in Portugal" Center & Department" Institution-wide"

Clients, employees, and our community will recognize RIBOGRAMA as a firm with:
Corporate culture centered on the core values of professionalism, fairness, integrity, trust, diversity, excellence, and teamwork Leaders who combine vision and practical experience with integrity Commitment to supporting diversity in our workforce

Obsession with quality in everything we do

These values differentiate RIBOGRAMA from the many other independent Cancer Research Lab in Portugal firms in the market today. We trust our staff to make decisions and to act based on values. RIBOGRAMA values are not just words, but embody everything we do.

The information contained in this document has been compiled in good faith by Global Partner Consulting. Participants should take note, however, that some of the information contained in this document is based on information provided to Global Partner Consulting by other entities as well as external sources and has not been independently verified by Global Partner Consulting. Participants should not rely on any material contained in this document as a statement or representation of fact, but should satisfy themselves as to its correctness by such independent investigation as they or their legal or financial advisers see fit. No liability for negligence or otherwise is assumed by Global Partner Consulting for the material contained in this document/ presentation.

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