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(4) ?a-.Ephedrineis a weaklybasiccornpoundwith pKu = 9.36. Whatis the K6 for ephedrine?'
X FK*:* Pk* + pk u
--l:l--=q.3b $ Tk u
'tu.rn
=ffi'1
\ \-/-r
(4) b. Write a chemical reaction with equilibrium constantequal to the yaiue calculatedin
'"
, it/t
! - l l L - _H
\t
f ' u = a " ? qx l b 5 + 2@sNc,L[nl
Z
B) df A pediatricianasksyou to preparea2Vo solutionof drugD in a flavoredsyrup. Drug D
is a weakacidwith pKn= 6.4, intrinsic solubilityof 0.006M, intrinsicpartition
coefficientof I0.2, andMW of I87.2 g/mole. You hayethreesyrupsavailable:orange,
grape,andcherrywhich arebufferedat pH2.8,6.0,and7.8,respectively.Which syrupor
syrupscouldyou use? Showwork andlogic whichjustifiesyour answer. _I
DIJnu=
J ^t, I
F,K*+ t"3 ' i;j- '
. i tq'-q,) >
PHp Sr:
W_ Pl(a
S'"r--*-L s . -* tCi,rgl** I
loo..'.s*-* tJ ffi- L D*on-r#
PH,j**b rr t r; 'g,*$nu.:
r*ri,*A
,oclbFl fr*rr"gs
\ )
T,\\ fi *^d
Y*'P =\,bt$ A 1,t03
Llt:"\
\'*p = lacc.use, Tp ^ pH o"bov€',1,(o?, bD
vnp
ffCg;.rt; -
Pr-.eCr"pulo*iOn[J-oril_ed
/ 4
\z/
v
a. ( TJor F Any compoundwhich producesOI{- when placed'inwatermust be a base.
\_/
vF r"$ A basiccompound
solutions
will bemoresolublein basic(ratherthanacidic)
"like
because dissolvefllike.'l
, / |{ + F{r,'""rf# l*1i-i-
V a. r odL) Theconjug#acid;if Y""i. uuiBi,l stbea strongacid.
/
A buffer must contain a conjugate-acid/conjugate'base
pair.
Q/e.(rdrF
HC! + l'/aAc d
You can make a buffer by mixing hydrochloric acid and sodium acetate.
j
7-
LY
' l
.3
)nk
@ry r"r'tss*t
(4) b. Write an equationwhich corresponds
to the graphabove.
\./ \^k = -Eo* L
+ rI n A -
e-'+
)^
- |
a4
{^J-
-:
>)-- 7>
Ll
/..-
I
?k^ lo = t*
V^'
(5) 8, The iahinsic solubilityof Phenobarbikl(a weakacid) is 0.005M. Given that theI!
andmolecularweightof Phenobarbital are3.9 x 10-8and?32.?3g/mole,what is the
/nost concenffatedsolutionwhich couldbe formulatedat pH 8.3?
F,^' :e-
Sr
K * = 3 , qx # foearl _ I .
tw= t*,"e}t-fiko.
3o= O'0A51
S,: L= 1"1{Cg 0dJ
4*
l -
Ir 63-rT,*l
i+lo
0.Do5r1
Ird
\t'(nsn)
Extra credit
116) c. Write an equationand sketch a graph showing how (SA) dependson time.
r ) V
i '
l(>
|tts Fi)-
oD
[;r ffi\
*rt&*pxi *Pk s *-*
10. Sulfisoxizoleis a weaklyaciddrug with Ku= 1.0x 10-5.Define(in termsof equiiibrium
concentrations)
thefollowing termsfor sulfisoxizole:
9
fracfion
(3)a. *nionized = {,li' = =Ls+
LI4SJSLS-J
*
a CIla.
apparenf
partition celt
coeffi --[utJ*
3$)"' intrinsicpartitioncoefficient=
Ko=
fU* o [-*,,,* iG-
fu* -
i1. Also'forsulfisoxizole,g(gfi thefollowing giaphsshowingasmuchdetail asI did in class
andindicatethepredominantchemicalspecie(s)presentat variouspoints.
p odd
\,t o'5
H\ 3-
"pk"=
5 )F\ )H
l3
?F"P*n
g,t;vt,qldl4r Ft"
Pt{
lvv
llr
,
lv't
l F Yo i* no*
\ ' -
c{-fl*st{#b*f
as, w ?ll
-r
>l >l
I
te
(9 12'a, Followingthei.v. administration of a 100mgdoseof drug-Xto an adultmalepatient,
plasma samples arecollectedat 3 hours andThourspost-administration. Laboratorv
I
analy_sisof the samplesyieldsf concentrationsof 15.2 yg/ml anclI0.l pglml."Given
fl\-
that the eliminationof drug-Nis known to occurasa L$-orderprocess,write an
equationwith numericalcoefficients(andproperunits)which describesthe
concentration of drug-fi in plasmaasa functionof time.
At = A'eTi
i A.=fl*/'* lo?rr'-ilav,"\ 1 1rt{it l0,Ir4lu*
t-^
t+\" = eO .bL+\rn_
-u-
ih4
t (t^'f
\j
sl /, lo
1r t h{5
l l t\[ = \n tn i o *\<,t
-('(*''r
I f;l:l$:[\y''u#)
(3) d What is the
volumeof distributioa(pretend:"volumeof plasma,')fothis patient?
/tr
{A"X-X u*
/+: clc.o,+#s
3 t
tcro4''o Y3
ls= *lb]ot ffi;tt@"
It=
,l
lXlo vlwr*, F lcf,yffih i
;"E
iv^>
; 1
,i,
'
t a" M . f
\ '/ (
,. \
I "-,/ ,,,
I t
I h
@tr@ , b
nnMT \ x'P "U