Code No: RR322303 Set No.

1
III B.Tech Supplimentary Examinations, Aug/Sep 2008
BIO-INFORMATICS
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. Describe the following:

(a) Uniform Resource Locator (URL)

(b) Role of Internet in Bioinformatics [16]

2. Write a note on Parametric sequence alignment? [16]

3. Describe any Iterative method of multiple sequence alignment? Give a note in

PHYLIP. [16]

4. Write a brief note on the following:

(a) Sub divisions of Genbank

(b) Structure of a genbank record [16]

5. Explain about Percent Accepted Mutation? [16]

6. Discus about relationships of Phylogenetic analysis to sequence alignment? [16]

7. Define Genome? Outline the structure and composition of prokaryotic and Eukary-
otic genomes? [16]

8. Write an essay on gene prediction in Microbial Genomes. [16]

⋆⋆⋆⋆⋆

1 of 1
Code No: RR322303 Set No. 2
III B.Tech Supplimentary Examinations, Aug/Sep 2008
BIO-INFORMATICS
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. Write short notes on:

(a) Structure of Internet

(b) URL general format [16]

2. What is Sequence alignment? How are sequence alignment tools classified and
explain about them? [16]

3. What is multiple sequence alignment? Describe the applications of multiple se-

quence alignments? [16]

4. Explain about FASTA sequence Database similarity searching? [16]

5. Describe the FAST Algorithm and its role in Database searching. [16]

6. Discus about relationships of Phylogenetic analysis to sequence alignment? [16]

7. Define Genome? Outline the structure and composition of prokaryotic and Eukary-
otic genomes? [16]

8. Write an essay on Gene finding and feature detection ion DNA? [16]

⋆⋆⋆⋆⋆

1 of 1
Code No: RR322303 Set No. 3
III B.Tech Supplimentary Examinations, Aug/Sep 2008
BIO-INFORMATICS
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. What is File Transfer Protocol (FTP)? Describe different types of FTP’s? [16]

2. What is local alignment? Describe the Smith -Waterman algorithm? [16]

3. What is a multiple alignment and why we do it? [16]

4. Write short notes on:

(a) Accession code & Identifier

(b) Gen Bank &DDBJ [16]

5. Name the Database search algorithm employed in alignment of sequences and ex-
plain in detail about any one of it? [16]

6. Discus about relationships of Phylogenetic analysis to sequence alignment? [16]

7. Define Genome? Outline the structure and composition of prokaryotic and Eukary-
otic genomes? [16]

8. What are Neural Networks? How they are useful in predicting a gene structure?
[16]

⋆⋆⋆⋆⋆

1 of 1
Code No: RR322303 Set No. 4
III B.Tech Supplimentary Examinations, Aug/Sep 2008
BIO-INFORMATICS
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. Write short notes on:

(a) Shannons formula

(b) Channel capacity [16]

2. Explain in detail about Dynamic: Programming method for sequence alignment?

[16]

3. What is a multiple alignment and why we do it? [16]

4. Define Secondary databases? Give an overview of secondary databases? [16]

5. What is Block Substitution Matrices (BLOSUM)? Describe them in detail? [16]

6. Describe the following:

(a) Perfect phylogeny

(b) The relationship of Phylogenetic analysis and sequence alignment. [16]

7. Describe the steps involved in sequence assembly? [16]

8. Write short notes on:

(a) GRAIL II
(b) ORF [16]

⋆⋆⋆⋆⋆

1 of 1