Documentos de Académico
Documentos de Profesional
Documentos de Cultura
PATHOPHYSIOLOGY
(BPH)
Exact cause is Idiopathic
Men-50 y/o & above Ethnicity
Diet Hormonal fx
Obesity Race
DM Family Hx
Smoking Alcohol use
Estrogen
Androgen
RISK FACTORS
Testosterone
5-alpha
Become sensitive reductase
to growth- Dihydrosterone
stimulating
hormone Hyperplasia
Binds to nuclear
androgen
receptors
Signals prostate
cell to replicate
Signals growth
factors
Late activation of
cell growth
Apoptosis
Hyperplasia
Symmetrically
enlarged gland
Narrows the Encroaches upon Growth of the so- Prostate capsule influence Accompanied by hypertrophy of the smooth
lumen of the the bladder neck called median lobe hyperplasia to expand muscle gland (Benign Prostatic Hypertrophy)
segment of the reducing the ability of the prostate outward
prostate to funnel in extends into the
response to proximal urethra
micturation Muscular tone at Mechanically adds to
Size of prostate the bladder neck & the tse. constricting
proximal urethra the urethral lumen
UTI
Hematuria OBSTRUCTION
LUTS
Associated w/ overactive
detrusor contractions
Peritonitis
Uremia
Weakened muscle
contraction