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Best rules found: 1. Research Activity=study 2828 ==> Disease-Class=Asthma 2828 conf:(1) 2.

SYMBOL=- 2049 ==> Disease-Class=Asthma 2049 conf:(1) 3. Idea or Concept=eligible 1624 ==> Disease-Class=Asthma 1624 conf:(1) 4. Disease or Syndrome=asthma 1613 ==> Disease-Class=Asthma 1613 conf:(1) 5. Idea or Concept=eligible Research Activity=study 1579 ==> Disease-Class=A sthma 1579 conf:(1) 6. Temporal Concept=years 1242 ==> Disease-Class=Asthma 1242 conf:(1) 7. Spatial Concept=within 1199 ==> Disease-Class=Asthma 1199 conf:(1) 8. NO=no 884 ==> Disease-Class=Asthma 884 conf:(1) 9. Laboratory Procedure=screening 805 ==> Disease-Class=Asthma 805 conf:( 1) 10. NO=exclusion criteria 802 ==> Disease-Class=Asthma 802 conf:(1) 11. Quantitative Concept=both 794 ==> Disease-Class=Asthma 794 conf:(1) 12. Individual Behavior=visit 786 ==> Disease-Class=Asthma 786 conf:(1) 13. Temporal Concept=years Research Activity=study 779 ==> Disease-Class=Asth ma 779 conf:(1) 14. Healthy Population=healthy volunteers 775 ==> Disease-Class=Asthma 775 conf:(1) 15. Quantitative Concept=both Research Activity=study 771 ==> Disease-Class=A sthma 771 conf:(1) 16. Qualitative Concept=accepts 768 ==> Disease-Class=Asthma 768 conf:(1) 17. Qualitative Concept=accepts Healthy Population=healthy volunteers 768 ==> Disease-Class=Asthma 768 conf:(1) 18. Organism Attribute=genders 767 ==> Disease-Class=Asthma 767 conf:(1) 19. Quantitative Concept=both Organism Attribute=genders 767 ==> Disease-Clas s=Asthma 767 conf:(1) 20. Quantitative Concept=both Idea or Concept=eligible 767 ==> Disease-Class= Asthma 767 conf:(1) 21. Organism Attribute=genders Idea or Concept=eligible 767 ==> Disease-Class =Asthma 767 conf:(1) 22. Organism Attribute=genders Research Activity=study 767 ==> Disease-Class= Asthma 767 conf:(1) 23. Quantitative Concept=both Organism Attribute=genders Idea or Concept=elig ible 767 ==> Disease-Class=Asthma 767 conf:(1) 24. Quantitative Concept=both Organism Attribute=genders Research Activity=st udy 767 ==> Disease-Class=Asthma 767 conf:(1) 25. Quantitative Concept=both Idea or Concept=eligible Research Activity=stud y 767 ==> Disease-Class=Asthma 767 conf:(1) 26. Organism Attribute=genders Idea or Concept=eligible Research Activity=stu dy 767 ==> Disease-Class=Asthma 767 conf:(1) 27. Quantitative Concept=both Organism Attribute=genders Idea or Concept=elig ible Research Activity=study 767 ==> Disease-Class=Asthma 767 conf:(1) 28. Qualitative Concept=inclusion criteria 762 ==> Disease-Class=Asthma 762 conf:(1) 29. Temporal Concept=years Idea or Concept=eligible 759 ==> Disease-Class=Ast hma 759 conf:(1) 30. Temporal Concept=years Idea or Concept=eligible Research Activity=study 7 55 ==> Disease-Class=Asthma 755 conf:(1) 31. SYMBOL=>= 729 ==> Disease-Class=Asthma 729 conf:(1) 32. Temporal Concept=prior to 712 ==> Disease-Class=Asthma 712 conf:(1) 33. NO=no Qualitative Concept=accepts 677 ==> Disease-Class=Asthma 677 con f:(1) 34. NO=no Healthy Population=healthy volunteers 677 ==> Disease-Class=Asthma 677 conf:(1) 35. NO=no Qualitative Concept=accepts Healthy Population=healthy volunteers 6 77 ==> Disease-Class=Asthma 677 conf:(1) 36. Human=subject 675 ==> Disease-Class=Asthma 675 conf:(1) 37. Patient or Disabled Group=patients 670 ==> Disease-Class=Asthma 670 co

nf:(1) 38. UNIT=% 630 ==> Disease-Class=Asthma 630 conf:(1) 39. Age Group=ages 622 ==> Disease-Class=Asthma 622 conf:(1) 40. Human=subjects 586 ==> Disease-Class=Asthma 586 conf:(1) 41. Research Activity=study Age Group=ages 581 ==> Disease-Class=Asthma 581 conf:(1) 42. Temporal Concept=years Age Group=ages 580 ==> Disease-Class=Asthma 580 conf:(1) 43. Idea or Concept=eligible Age Group=ages 578 ==> Disease-Class=Asthma 578 conf:(1) 44. Idea or Concept=eligible Research Activity=study Age Group=ages 578 ==> D isease-Class=Asthma 578 conf:(1) 45. Temporal Concept=years Research Activity=study Age Group=ages 565 ==> Dis ease-Class=Asthma 565 conf:(1) 46. Temporal Concept=years Idea or Concept=eligible Age Group=ages 564 ==> Di sease-Class=Asthma 564 conf:(1) 47. Temporal Concept=years Idea or Concept=eligible Research Activity=study A ge Group=ages 564 ==> Disease-Class=Asthma 564 conf:(1) 48. NUMERAL=1.0 547 ==> Disease-Class=Asthma 547 conf:(1) 49. SYMBOL=> 527 ==> Disease-Class=Asthma 527 conf:(1) 50. Diagnostic Procedure=fev1 496 ==> Disease-Class=Asthma 496 conf:(1) 51. Activity=inhaled 489 ==> Disease-Class=Asthma 489 conf:(1) 52. Temporal Concept=history of 483 ==> Disease-Class=Asthma 483 conf:(1) 53. NO=not 474 ==> Disease-Class=Asthma 474 conf:(1) 54. Temporal Concept=months 464 ==> Disease-Class=Asthma 464 conf:(1) 55. UNIT=% Diagnostic Procedure=fev1 446 ==> Disease-Class=Asthma 446 conf :(1) 56. Therapeutic or Preventive Procedure=treatment 426 ==> Disease-Class=Asthm a 426 conf:(1) 57. Qualitative Concept=other 410 ==> Disease-Class=Asthma 410 conf:(1) 58. NUMERAL=12.0 387 ==> Disease-Class=Asthma 387 conf:(1) 59. Functional Concept=use of 371 ==> Disease-Class=Asthma 371 conf:(1) 60. NUMERAL=6.0 357 ==> Disease-Class=Asthma 357 conf:(1) 61. Body Space or Junction=oral 356 ==> Disease-Class=Asthma 356 conf:(1) 62. SYMBOL=< 350 ==> Disease-Class=Asthma 350 conf:(1) 63. NUMERAL=2.0 349 ==> Disease-Class=Asthma 349 conf:(1) 64. SYMBOL=- Disease or Syndrome=asthma 345 ==> Disease-Class=Asthma 345 c onf:(1) 65. NUMERAL=4.0 341 ==> Disease-Class=Asthma 341 conf:(1) 66. Patient or Disabled Group=patient 339 ==> Disease-Class=Asthma 339 con f:(1) 67. NUMERAL=3.0 337 ==> Disease-Class=Asthma 337 conf:(1) 68. Spatial Concept=within Individual Behavior=visit 319 ==> Disease-Class=As thma 319 conf:(1) 69. Idea or Concept=predicted 306 ==> Disease-Class=Asthma 306 conf:(1) 70. Laboratory Procedure=screening Individual Behavior=visit 306 ==> DiseaseClass=Asthma 306 conf:(1) 71. NUMERAL=1.0 Individual Behavior=visit 299 ==> Disease-Class=Asthma 299 conf:(1) 72. Organism Attribute=female 288 ==> Disease-Class=Asthma 288 conf:(1) 73. UNIT=% Idea or Concept=predicted 288 ==> Disease-Class=Asthma 288 conf :(1) 74. Temporal Concept=weeks 286 ==> Disease-Class=Asthma 286 conf:(1) 75. Spatial Concept=within Laboratory Procedure=screening 284 ==> Disease-Cla ss=Asthma 284 conf:(1) 76. Health Care Activity=diagnosis 277 ==> Disease-Class=Asthma 277 conf:( 1) 77. Temporal Concept=prior to Spatial Concept=within 276 ==> Disease-Class=As thma 276 conf:(1) 78. Age Group=age 271 ==> Disease-Class=Asthma 271 conf:(1)

79. SYMBOL=- Spatial Concept=within 265 ==> Disease-Class=Asthma 265 (1)

conf:

80. Functional Concept=non 264 ==> Disease-Class=Asthma 264 conf:(1) 81. SYMBOL=- Research Activity=study 262 ==> Disease-Class=Asthma 262 conf :(1) 82. Idea or Concept=predicted Diagnostic Procedure=fev1 259 ==> Disease-Class =Asthma 259 conf:(1) 83. Professional or Occupational Group=investigator 256 ==> Disease-Class=Ast hma 256 conf:(1) 84. Qualitative Concept=last 253 ==> Disease-Class=Asthma 253 conf:(1) 85. Temporal Concept=prior to Individual Behavior=visit 252 ==> Disease-Class =Asthma 252 conf:(1) 86. Qualitative Concept=significant 250 ==> Disease-Class=Asthma 250 conf: (1) 87. UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 249 ==> Diseas e-Class=Asthma 249 conf:(1) 88. Idea or Concept=acting 245 ==> Disease-Class=Asthma 245 conf:(1) 89. Pharmacologic Substance=corticosteroids 244 ==> Disease-Class=Asthma 244 conf:(1) 90. Pharmacologic Substance=medication 237 ==> Disease-Class=Asthma 237 co nf:(1) 91. Age Group=older 237 ==> Disease-Class=Asthma 237 conf:(1) 92. Research Activity=study Spatial Concept=within 230 ==> Disease-Class=Asth ma 230 conf:(1) 93. Temporal Concept=prior to Laboratory Procedure=screening 226 ==> DiseaseClass=Asthma 226 conf:(1) 94. NUMERAL=18.0 223 ==> Disease-Class=Asthma 223 conf:(1) 95. Research Activity=study Human=subject 221 ==> Disease-Class=Asthma 221 conf:(1) 96. Temporal Concept=years Age Group=older 216 ==> Disease-Class=Asthma 216 conf:(1) 97. Functional Concept=use 215 ==> Disease-Class=Asthma 215 conf:(1) 98. Spatial Concept=within Disease or Syndrome=asthma 214 ==> Disease-Class=A sthma 214 conf:(1) 99. Sign or Symptom=symptoms 212 ==> Disease-Class=Asthma 212 conf:(1) 100. NUMERAL=10.0 207 ==> Disease-Class=Asthma 207 conf:(1) 101. NUMERAL=1.0 Spatial Concept=within 205 ==> Disease-Class=Asthma 205 co nf:(1) 102. Qualitative Concept=has 204 ==> Disease-Class=Asthma 204 conf:(1) 103. Qualitative Concept=from 203 ==> Disease-Class=Asthma 203 conf:(1) 104. SYMBOL=- Functional Concept=non 203 ==> Disease-Class=Asthma 203 conf: (1) 105. Temporal Concept=years SYMBOL=- 198 ==> Disease-Class=Asthma 198 conf: (1) 106. SYMBOL=>= Disease or Syndrome=asthma 198 ==> Disease-Class=Asthma 198 conf:(1) 107. Research Activity=study Age Group=older 195 ==> Disease-Class=Asthma 195 conf:(1) 108. Regulation or Law=informed consent 192 ==> Disease-Class=Asthma 192 co nf:(1) 109. Temporal Concept=years Research Activity=study Age Group=older 192 ==> Di sease-Class=Asthma 192 conf:(1) 110. Idea or Concept=eligible Age Group=older 190 ==> Disease-Class=Asthma 190 conf:(1) 111. Temporal Concept=years Idea or Concept=eligible Age Group=older 190 ==> D isease-Class=Asthma 190 conf:(1) 112. Idea or Concept=eligible Research Activity=study Age Group=older 189 ==> Disease-Class=Asthma 189 conf:(1) 113. Temporal Concept=years Idea or Concept=eligible Research Activity=study A ge Group=older 189 ==> Disease-Class=Asthma 189 conf:(1)

114. SYMBOL=- Individual Behavior=visit 188 ==> Disease-Class=Asthma 188 co nf:(1) 115. Capacity=able to 187 ==> Disease-Class=Asthma 187 conf:(1) 116. Temporal Concept=years NUMERAL=18.0 186 ==> Disease-Class=Asthma 186 c onf:(1) 117. SYMBOL=- Laboratory Procedure=screening 185 ==> Disease-Class=Asthma 185 conf:(1) 118. Temporal Concept=prior to Disease or Syndrome=asthma 183 ==> Disease-Clas s=Asthma 183 conf:(1) 119. Quantitative Concept=baseline 179 ==> Disease-Class=Asthma 179 conf:(1 ) 120. Functional Concept=including 179 ==> Disease-Class=Asthma 179 conf:(1) 121. Temporal Concept=months Spatial Concept=within 179 ==> Disease-Class=Asth ma 179 conf:(1) 122. Health Care Activity=diagnosis Disease or Syndrome=asthma 178 ==> Disease -Class=Asthma 178 conf:(1) 123. Quantitative Concept=exacerbation 176 ==> Disease-Class=Asthma 176 con f:(1) 124. Temporal Concept=before 175 ==> Disease-Class=Asthma 175 conf:(1) 125. Temporal Concept=day 174 ==> Disease-Class=Asthma 174 conf:(1) 126. Temporal Concept=weeks Spatial Concept=within 172 ==> Disease-Class=Asthm a 172 conf:(1) 127. Temporal Concept=year 170 ==> Disease-Class=Asthma 170 conf:(1) 128. Quantitative Concept=dose 164 ==> Disease-Class=Asthma 164 conf:(1) 129. Organism Attribute=females 163 ==> Disease-Class=Asthma 163 conf:(1) 130. Functional Concept=using 163 ==> Disease-Class=Asthma 163 conf:(1) 131. SYMBOL=- Idea or Concept=acting 162 ==> Disease-Class=Asthma 162 conf: (1) 132. NUMERAL=65.0 161 ==> Disease-Class=Asthma 161 conf:(1) 133. Quantitative Concept=one 161 ==> Disease-Class=Asthma 161 conf:(1) 134. NUMERAL=5.0 159 ==> Disease-Class=Asthma 159 conf:(1) 135. NUMERAL=30.0 159 ==> Disease-Class=Asthma 159 conf:(1) 136. Temporal Concept=current 158 ==> Disease-Class=Asthma 158 conf:(1) 137. Temporal Concept=months NUMERAL=6.0 158 ==> Disease-Class=Asthma 158 c onf:(1) 138. SYMBOL=- Activity=inhaled 157 ==> Disease-Class=Asthma 157 conf:(1) 139. Temporal Concept=period 156 ==> Disease-Class=Asthma 156 conf:(1) 140. Disease or Syndrome=asthma Individual Behavior=visit 154 ==> Disease-Clas s=Asthma 154 conf:(1) 141. NUMERAL=1.0 Spatial Concept=within Individual Behavior=visit 154 ==> Dise ase-Class=Asthma 154 conf:(1) 142. Functional Concept=systemic 153 ==> Disease-Class=Asthma 153 conf:(1) 143. Temporal Concept=days 151 ==> Disease-Class=Asthma 151 conf:(1) 144. Qualitative Concept=beta 151 ==> Disease-Class=Asthma 151 conf:(1) 145. Functional Concept=requiring 151 ==> Disease-Class=Asthma 151 conf:(1) 146. Professional or Occupational Group=physician 150 ==> Disease-Class=Asthma 150 conf:(1) 147. Temporal Concept=during 149 ==> Disease-Class=Asthma 149 conf:(1) 148. NUMERAL=70.0 149 ==> Disease-Class=Asthma 149 conf:(1) 149. Patient or Disabled Group=patients Disease or Syndrome=asthma 148 ==> Dis ease-Class=Asthma 148 conf:(1) 150. Pharmacologic Substance=medications 147 ==> Disease-Class=Asthma 147 c onf:(1) 151. Temporal Concept=prior to Research Activity=study 147 ==> Disease-Class=A sthma 147 conf:(1) 152. Research Activity=study Disease or Syndrome=asthma 147 ==> Disease-Class= Asthma 147 conf:(1) 153. SYMBOL=>= UNIT=% 145 ==> Disease-Class=Asthma 145 conf:(1) 154. Individual Behavior=participation 144 ==> Disease-Class=Asthma 144 con f:(1)

155. Temporal Concept=years Age Group=age 144 ==> Disease-Class=Asthma 144 conf:(1) 156. Disease or Syndrome=ics 142 ==> Disease-Class=Asthma 142 conf:(1) 157. Spatial Concept=between 141 ==> Disease-Class=Asthma 141 conf:(1) 158. Spatial Concept=within Body Space or Junction=oral 141 ==> Disease-Class= Asthma 141 conf:(1) 159. Temporal Concept=prior to SYMBOL=>= 140 ==> Disease-Class=Asthma 140 c onf:(1) 160. Health Care Activity=documented 139 ==> Disease-Class=Asthma 139 conf: (1) 161. SYMBOL=- UNIT=% 139 ==> Disease-Class=Asthma 139 conf:(1) 162. NUMERAL=18.0 Research Activity=study 139 ==> Disease-Class=Asthma 139 conf:(1) 163. Therapeutic or Preventive Procedure=therapy 138 ==> Disease-Class=Asthma 138 conf:(1) 164. Temporal Concept=prior to NUMERAL=1.0 138 ==> Disease-Class=Asthma 138 conf:(1) 165. Temporal Concept=months Disease or Syndrome=asthma 137 ==> Disease-Class= Asthma 137 conf:(1) 166. SYMBOL=>= Laboratory Procedure=screening 137 ==> Disease-Class=Asthma 137 conf:(1) 167. Pharmacologic Substance=drug 136 ==> Disease-Class=Asthma 136 conf:(1) 168. SYMBOL=- Human=subject 136 ==> Disease-Class=Asthma 136 conf:(1) 169. Research Activity=entry 134 ==> Disease-Class=Asthma 134 conf:(1) 170. Patient or Disabled Group=patients SYMBOL=- 134 ==> Disease-Class=Asthma 134 conf:(1) 171. NUMERAL=4.0 Spatial Concept=within 134 ==> Disease-Class=Asthma 134 co nf:(1) 172. Temporal Concept=years NUMERAL=18.0 Research Activity=study 134 ==> Disea se-Class=Asthma 134 conf:(1) 173. Temporal Concept=prior to Spatial Concept=within Individual Behavior=visi t 133 ==> Disease-Class=Asthma 133 conf:(1) 174. Spatial Concept=within Laboratory Procedure=screening Individual Behavior =visit 133 ==> Disease-Class=Asthma 133 conf:(1) 175. Intellectual Product=criteria 132 ==> Disease-Class=Asthma 132 conf:(1 ) 176. Disease or Syndrome=asthma Laboratory Procedure=screening 132 ==> Disease -Class=Asthma 132 conf:(1) 177. Qualitative Concept=other Disease or Syndrome=asthma 131 ==> Disease-Clas s=Asthma 131 conf:(1) 178. Finding=written 130 ==> Disease-Class=Asthma 130 conf:(1) 179. NUMERAL=60.0 129 ==> Disease-Class=Asthma 129 conf:(1) 180. NUMERAL=18.0 Idea or Concept=eligible 129 ==> Disease-Class=Asthma 129 conf:(1) 181. Research Activity=study Professional or Occupational Group=investigator 1 29 ==> Disease-Class=Asthma 129 conf:(1) 182. Therapeutic or Preventive Procedure=treatment Disease or Syndrome=asthma 129 ==> Disease-Class=Asthma 129 conf:(1) 183. Pharmacologic Substance=corticosteroids Body Space or Junction=oral 128 = => Disease-Class=Asthma 128 conf:(1) 184. NO=not Research Activity=study 128 ==> Disease-Class=Asthma 128 conf:( 1) 185. Temporal Concept=years NUMERAL=18.0 Idea or Concept=eligible 128 ==> Dise ase-Class=Asthma 128 conf:(1) 186. NUMERAL=18.0 Idea or Concept=eligible Research Activity=study 128 ==> Dis ease-Class=Asthma 128 conf:(1) 187. Temporal Concept=years NUMERAL=65.0 127 ==> Disease-Class=Asthma 127 c onf:(1) 188. Temporal Concept=years NUMERAL=18.0 Idea or Concept=eligible Research Act ivity=study 127 ==> Disease-Class=Asthma 127 conf:(1)

189. Population Group=women 126 ==> Disease-Class=Asthma 126 conf:(1) 190. Qualitative Concept=positive 125 ==> Disease-Class=Asthma 125 conf:(1) 191. Finding=smoking history 124 ==> Disease-Class=Asthma 124 conf:(1) 192. NUMERAL=12.0 Research Activity=study 124 ==> Disease-Class=Asthma 124 conf:(1) 193. Quantitative Concept=short 123 ==> Disease-Class=Asthma 123 conf:(1) 194. Diagnostic Procedure=diagnosed 123 ==> Disease-Class=Asthma 123 conf:( 1) 195. Temporal Concept=years NUMERAL=12.0 122 ==> Disease-Class=Asthma 122 c onf:(1) 196. Temporal Concept=months NUMERAL=3.0 122 ==> Disease-Class=Asthma 122 c onf:(1) 197. Temporal Concept=months SYMBOL=>= 121 ==> Disease-Class=Asthma 121 con f:(1) 198. SYMBOL== 119 ==> Disease-Class=Asthma 119 conf:(1) 199. Pharmacologic Substance=steroids 118 ==> Disease-Class=Asthma 118 conf :(1) 200. Temporal Concept=prior to SYMBOL=- 118 ==> Disease-Class=Asthma 118 co nf:(1) 201. SYMBOL=- Human=subjects 117 ==> Disease-Class=Asthma 117 conf:(1) 202. NUMERAL=18.0 Age Group=older 117 ==> Disease-Class=Asthma 117 conf:(1) 203. Research Activity=study Human=subjects 117 ==> Disease-Class=Asthma 117 conf:(1) 204. Temporal Concept=weeks NUMERAL=4.0 116 ==> Disease-Class=Asthma 116 co nf:(1) 205. SYMBOL=> UNIT=% 116 ==> Disease-Class=Asthma 116 conf:(1) 206. Quantitative Concept=ml 115 ==> Disease-Class=Asthma 115 conf:(1) 207. Disease or Syndrome=disease 115 ==> Disease-Class=Asthma 115 conf:(1) 208. SYMBOL=- Age Group=age 115 ==> Disease-Class=Asthma 115 conf:(1) 209. SYMBOL=< UNIT=% 115 ==> Disease-Class=Asthma 115 conf:(1) 210. SYMBOL=>= Diagnostic Procedure=fev1 115 ==> Disease-Class=Asthma 115 c onf:(1) 211. Temporal Concept=prior to NUMERAL=1.0 Individual Behavior=visit 114 ==> D isease-Class=Asthma 114 conf:(1) 212. NUMERAL=6.0 Disease or Syndrome=asthma 113 ==> Disease-Class=Asthma 113 conf:(1) 213. Quantitative Concept=exacerbation Disease or Syndrome=asthma 113 ==> Dise ase-Class=Asthma 113 conf:(1) 214. Intellectual Product=pack years 112 ==> Disease-Class=Asthma 112 conf: (1) 215. SYMBOL=<= 112 ==> Disease-Class=Asthma 112 conf:(1) 216. Qualitative Concept=stable 112 ==> Disease-Class=Asthma 112 conf:(1) 217. Sign or Symptom=run 112 ==> Disease-Class=Asthma 112 conf:(1) 218. Allergy=allergy 112 ==> Disease-Class=Asthma 112 conf:(1) 219. NO=not SYMBOL=- 112 ==> Disease-Class=Asthma 112 conf:(1) 220. NUMERAL=1.0 Disease or Syndrome=asthma 112 ==> Disease-Class=Asthma 112 conf:(1) 221. UNIT=% Laboratory Procedure=screening 112 ==> Disease-Class=Asthma 112 conf:(1) 222. Functional Concept=participate 111 ==> Disease-Class=Asthma 111 conf:( 1) 223. SYMBOL=- Qualitative Concept=beta 111 ==> Disease-Class=Asthma 111 con f:(1) 224. Pharmacologic Substance=agonist 110 ==> Disease-Class=Asthma 110 conf: (1) 225. Idea or Concept=opinion 110 ==> Disease-Class=Asthma 110 conf:(1) 226. SYMBOL=- NUMERAL=2.0 110 ==> Disease-Class=Asthma 110 conf:(1) 227. SYMBOL=- Diagnostic Procedure=fev1 110 ==> Disease-Class=Asthma 110 co nf:(1) 228. Temporal Concept=years NUMERAL=18.0 Age Group=older 110 ==> Disease-Class

=Asthma 110 conf:(1) 229. Willing=willing 109 ==> Disease-Class=Asthma 109 conf:(1) 230. NO=not Human=subject 109 ==> Disease-Class=Asthma 109 conf:(1) 231. Quantitative Concept=short Idea or Concept=acting 109 ==> Disease-Class=A sthma 109 conf:(1) 232. Research Activity=study Individual Behavior=visit 109 ==> Disease-Class=A sthma 109 conf:(1) 233. SYMBOL=>= UNIT=% Diagnostic Procedure=fev1 109 ==> Disease-Class=Asthma 1 09 conf:(1) 234. Quantitative Concept=pack 108 ==> Disease-Class=Asthma 108 conf:(1) 235. Behavior Problem=smoking 108 ==> Disease-Class=Asthma 108 conf:(1) 236. SYMBOL=>= NUMERAL=6.0 108 ==> Disease-Class=Asthma 108 conf:(1) 237. Idea or Concept=acting Activity=inhaled 108 ==> Disease-Class=Asthma 108 conf:(1) 238. Temporal Concept=after 107 ==> Disease-Class=Asthma 107 conf:(1) 239. Quantitative Concept=all 107 ==> Disease-Class=Asthma 107 conf:(1) 240. Individual Behavior=visits 106 ==> Disease-Class=Asthma 106 conf:(1) 241. Contraception=contraception 106 ==> Disease-Class=Asthma 106 conf:(1) 242. Disease or Syndrome=asthma Sign or Symptom=symptoms 106 ==> Disease-Class =Asthma 106 conf:(1) 243. Research Activity=trial 105 ==> Disease-Class=Asthma 105 conf:(1) 244. SYMBOL=- Therapeutic or Preventive Procedure=treatment 104 ==> Disease-Cl ass=Asthma 104 conf:(1) 245. Temporal Concept=prior to Spatial Concept=within Laboratory Procedure=scr eening 104 ==> Disease-Class=Asthma 104 conf:(1) 246. NUMERAL=18.0 Research Activity=study Age Group=older 104 ==> Disease-Clas s=Asthma 104 conf:(1) 247. Temporal Concept=persistent 103 ==> Disease-Class=Asthma 103 conf:(1) 248. Health Care Activity=enrollment 102 ==> Disease-Class=Asthma 102 conf: (1) 249. Temporal Concept=month 102 ==> Disease-Class=Asthma 102 conf:(1) 250. Activity=interfere 102 ==> Disease-Class=Asthma 102 conf:(1) 251. Capacity=ability 102 ==> Disease-Class=Asthma 102 conf:(1) 252. SYMBOL=>= NUMERAL=1.0 102 ==> Disease-Class=Asthma 102 conf:(1) 253. NUMERAL=12.0 Spatial Concept=within 102 ==> Disease-Class=Asthma 102 c onf:(1) 254. Qualitative Concept=last Spatial Concept=within 102 ==> Disease-Class=Ast hma 102 conf:(1) 255. Pharmacologic Substance=bronchodilator 101 ==> Disease-Class=Asthma 101 conf:(1) 256. Qualitative Concept=known 101 ==> Disease-Class=Asthma 101 conf:(1) 257. Age Group=aged 101 ==> Disease-Class=Asthma 101 conf:(1) 258. UNIT=% Individual Behavior=visit 101 ==> Disease-Class=Asthma 101 conf :(1) 259. Temporal Concept=years NUMERAL=18.0 Research Activity=study Age Group=old er 101 ==> Disease-Class=Asthma 101 conf:(1) 260. MARK=] 100 ==> Disease-Class=Asthma 100 conf:(1) 261. NUMERAL=65.0 Research Activity=study 100 ==> Disease-Class=Asthma 100 conf:(1) 262. Spatial Concept=within Human=subject 100 ==> Disease-Class=Asthma 100 conf:(1) 263. Disease or Syndrome=asthma Professional or Occupational Group=physician 1 00 ==> Disease-Class=Asthma 100 conf:(1) 264. NUMERAL=18.0 Idea or Concept=eligible Age Group=older 100 ==> Disease-Cla ss=Asthma 100 conf:(1) 265. Temporal Concept=years NUMERAL=18.0 Idea or Concept=eligible Age Group=ol der 100 ==> Disease-Class=Asthma 100 conf:(1) 266. Health Care Activity=hospitalization 99 ==> Disease-Class=Asthma 99 co nf:(1) 267. Research Activity=randomization 99 ==> Disease-Class=Asthma 99 conf:(1

) 268. SYMBOL=- NUMERAL=1.0 99 ==> Disease-Class=Asthma 99 conf:(1) 269. NUMERAL=65.0 Idea or Concept=eligible 99 ==> Disease-Class=Asthma 99 c onf:(1) 270. NUMERAL=65.0 Age Group=ages 99 ==> Disease-Class=Asthma 99 conf:(1) 271. SYMBOL=- UNIT=% Diagnostic Procedure=fev1 99 ==> Disease-Class=Asthma 99 conf:(1) 272. NUMERAL=65.0 Idea or Concept=eligible Research Activity=study 99 ==> Dise ase-Class=Asthma 99 conf:(1) 273. NUMERAL=18.0 Idea or Concept=eligible Research Activity=study Age Group=o lder 99 ==> Disease-Class=Asthma 99 conf:(1) 274. Temporal Concept=years NUMERAL=18.0 Idea or Concept=eligible Research Act ivity=study Age Group=older 99 ==> Disease-Class=Asthma 99 conf:(1) 275. UNIT=time 98 ==> Disease-Class=Asthma 98 conf:(1) 276. Qualitative Concept=protocol 98 ==> Disease-Class=Asthma 98 conf:(1) 277. NUMERAL=6.0 Spatial Concept=within 98 ==> Disease-Class=Asthma 98 conf :(1) 278. NUMERAL=1.0 Laboratory Procedure=screening 98 ==> Disease-Class=Asthma 98 conf:(1) 279. Laboratory Procedure=screening Human=subject 98 ==> Disease-Class=Asthma 98 conf:(1) 280. Temporal Concept=years NUMERAL=65.0 Idea or Concept=eligible 98 ==> Disea se-Class=Asthma 98 conf:(1) 281. Temporal Concept=years NUMERAL=65.0 Research Activity=study 98 ==> Diseas e-Class=Asthma 98 conf:(1) 282. Temporal Concept=years NUMERAL=65.0 Idea or Concept=eligible Research Act ivity=study 98 ==> Disease-Class=Asthma 98 conf:(1) 283. NUMERAL=80.0 97 ==> Disease-Class=Asthma 97 conf:(1) 284. Organic Chemical=methacholine 97 ==> Disease-Class=Asthma 97 conf:(1) 285. Temporal Concept=during Research Activity=study 97 ==> Disease-Class=Asth ma 97 conf:(1) 286. SYMBOL=- Sign or Symptom=run 97 ==> Disease-Class=Asthma 97 conf:(1) 287. NUMERAL=3.0 Spatial Concept=within 97 ==> Disease-Class=Asthma 97 conf :(1) 288. Research Activity=study Individual Behavior=participation 97 ==> DiseaseClass=Asthma 97 conf:(1) 289. Temporal Concept=years NUMERAL=65.0 Age Group=ages 97 ==> Disease-Class=A sthma 97 conf:(1) 290. NUMERAL=65.0 Idea or Concept=eligible Age Group=ages 97 ==> Disease-Class =Asthma 97 conf:(1) 291. NUMERAL=65.0 Research Activity=study Age Group=ages 97 ==> Disease-Class= Asthma 97 conf:(1) 292. NUMERAL=65.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 97 ==> Disease-Class=Asthma 97 conf:(1) 293. Temporal Concept=years NUMERAL=65.0 Idea or Concept=eligible Age Group=ag es 96 ==> Disease-Class=Asthma 96 conf:(1) 294. Temporal Concept=years NUMERAL=65.0 Research Activity=study Age Group=age s 96 ==> Disease-Class=Asthma 96 conf:(1) 295. Temporal Concept=years NUMERAL=65.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 96 ==> Disease-Class=Asthma 96 conf:(1) 296. Quantitative Concept=mcg 95 ==> Disease-Class=Asthma 95 conf:(1) 297. Finding=written Regulation or Law=informed consent 95 ==> Disease-Class=A sthma 95 conf:(1) 298. Temporal Concept=prior to Laboratory Procedure=screening Individual Behav ior=visit 95 ==> Disease-Class=Asthma 95 conf:(1) 299. Qualitative Concept=acceptable 94 ==> Disease-Class=Asthma 94 conf:(1) 300. Therapeutic or Preventive Procedure=procedures 94 ==> Disease-Class=Asthm a 94 conf:(1) 301. Behavior Problem=smokers 94 ==> Disease-Class=Asthma 94 conf:(1) 302. Spatial Concept=within Activity=inhaled 94 ==> Disease-Class=Asthma 94

conf:(1) 303. Laboratory Procedure=screening Diagnostic Procedure=fev1 94 ==> Disease-C lass=Asthma 94 conf:(1) 304. Pharmacologic Substance=corticosteroids Activity=inhaled 93 ==> Disease-C lass=Asthma 93 conf:(1) 305. NUMERAL=3.0 Disease or Syndrome=asthma 93 ==> Disease-Class=Asthma 93 conf:(1) 306. NUMERAL=12.0 Idea or Concept=eligible 93 ==> Disease-Class=Asthma 93 c onf:(1) 307. Functional Concept=required 92 ==> Disease-Class=Asthma 92 conf:(1) 308. Geographic Area=yes 92 ==> Disease-Class=Asthma 92 conf:(1) 309. Geographic Area=ie 92 ==> Disease-Class=Asthma 92 conf:(1) 310. Therapeutic or Preventive Procedure=treatment Spatial Concept=within 92 = => Disease-Class=Asthma 92 conf:(1) 311. Pharmacologic Substance=albuterol 91 ==> Disease-Class=Asthma 91 conf: (1) 312. Functional Concept=used 91 ==> Disease-Class=Asthma 91 conf:(1) 313. Age Group=child 91 ==> Disease-Class=Asthma 91 conf:(1) 314. Pharmacologic Substance=corticosteroids Spatial Concept=within 91 ==> Dis ease-Class=Asthma 91 conf:(1) 315. Qualitative Concept=accepts Geographic Area=yes 91 ==> Disease-Class=Asth ma 91 conf:(1) 316. Disease or Syndrome=asthma Activity=inhaled 91 ==> Disease-Class=Asthma 9 1 conf:(1) 317. Geographic Area=yes Healthy Population=healthy volunteers 91 ==> DiseaseClass=Asthma 91 conf:(1) 318. Temporal Concept=years NUMERAL=12.0 Idea or Concept=eligible 91 ==> Disea se-Class=Asthma 91 conf:(1) 319. NUMERAL=12.0 Idea or Concept=eligible Research Activity=study 91 ==> Dise ase-Class=Asthma 91 conf:(1) 320. Qualitative Concept=accepts Geographic Area=yes Healthy Population=health y volunteers 91 ==> Disease-Class=Asthma 91 conf:(1) 321. Finding=life 90 ==> Disease-Class=Asthma 90 conf:(1) 322. SYMBOL=>= Individual Behavior=visit 90 ==> Disease-Class=Asthma 90 con f:(1) 323. Therapeutic or Preventive Procedure=treatment Activity=inhaled 90 ==> Dis ease-Class=Asthma 90 conf:(1) 324. Temporal Concept=years NUMERAL=12.0 Research Activity=study 90 ==> Diseas e-Class=Asthma 90 conf:(1) 325. Temporal Concept=years NUMERAL=12.0 Idea or Concept=eligible Research Act ivity=study 90 ==> Disease-Class=Asthma 90 conf:(1) 326. Functional Concept=active 89 ==> Disease-Class=Asthma 89 conf:(1) 327. Pharmacologic Substance=medication Research Activity=study 89 ==> Disease -Class=Asthma 89 conf:(1) 328. SYMBOL=> Diagnostic Procedure=fev1 89 ==> Disease-Class=Asthma 89 conf :(1) 329. Functional Concept=use of Spatial Concept=within 89 ==> Disease-Class=Ast hma 89 conf:(1) 330. Temporal Concept=chronic 88 ==> Disease-Class=Asthma 88 conf:(1) 331. NUMERAL=75.0 88 ==> Disease-Class=Asthma 88 conf:(1) 332. NUMERAL=30.0 Spatial Concept=within 88 ==> Disease-Class=Asthma 88 con f:(1) 333. Functional Concept=use of Activity=inhaled 88 ==> Disease-Class=Asthma 88 conf:(1) 334. Temporal Concept=currently 87 ==> Disease-Class=Asthma 87 conf:(1) 335. NUMERAL=50.0 87 ==> Disease-Class=Asthma 87 conf:(1) 336. Organism Function=pregnant 87 ==> Disease-Class=Asthma 87 conf:(1) 337. SYMBOL=- NUMERAL=10.0 87 ==> Disease-Class=Asthma 87 conf:(1) 338. SYMBOL=- Finding=life 87 ==> Disease-Class=Asthma 87 conf:(1) 339. Disease or Syndrome=asthma Diagnostic Procedure=diagnosed 87 ==> Disease-

Class=Asthma 87 conf:(1) 340. SYMBOL=- Laboratory Procedure=screening Individual Behavior=visit 87 ==> Disease-Class=Asthma 87 conf:(1) 341. Quantitative Concept=or more 86 ==> Disease-Class=Asthma 86 conf:(1) 342. SYMBOL=- Quantitative Concept=short 86 ==> Disease-Class=Asthma 86 con f:(1) 343. NUMERAL=10.0 Finding=smoking history 86 ==> Disease-Class=Asthma 86 co nf:(1) 344. UNIT=% Laboratory Procedure=screening Diagnostic Procedure=fev1 86 ==> Di sease-Class=Asthma 86 conf:(1) 345. Therapeutic or Preventive Procedure=administration 85 ==> Disease-Class=A sthma 85 conf:(1) 346. Patient or Disabled Group=patient Research Activity=study 85 ==> DiseaseClass=Asthma 85 conf:(1) 347. Temporal Concept=years NUMERAL=10.0 85 ==> Disease-Class=Asthma 85 con f:(1) 348. SYMBOL=- Quantitative Concept=pack 85 ==> Disease-Class=Asthma 85 conf :(1) 349. Organism Attribute=female Human=subjects 85 ==> Disease-Class=Asthma 85 conf:(1) 350. Individual Behavior=visit Human=subject 85 ==> Disease-Class=Asthma 85 conf:(1) 351. Intellectual Product=guidelines 84 ==> Disease-Class=Asthma 84 conf:(1 ) 352. NUMERAL=8.0 84 ==> Disease-Class=Asthma 84 conf:(1) 353. Qualitative Concept=pre 84 ==> Disease-Class=Asthma 84 conf:(1) 354. Organism Function=pregnancy 84 ==> Disease-Class=Asthma 84 conf:(1) 355. Patient or Disabled Group=patients Individual Behavior=visit 84 ==> Disea se-Class=Asthma 84 conf:(1) 356. NUMERAL=1.0 Research Activity=study 84 ==> Disease-Class=Asthma 84 con f:(1) 357. Disease or Syndrome=asthma Human=subjects 84 ==> Disease-Class=Asthma 84 conf:(1) 358. Disease or Syndrome=asthma Human=subject 84 ==> Disease-Class=Asthma 84 conf:(1) 359. Patient or Disabled Group=patients Research Activity=study 83 ==> Disease -Class=Asthma 83 conf:(1) 360. Temporal Concept=history of Disease or Syndrome=asthma 83 ==> Disease-Cla ss=Asthma 83 conf:(1) 361. SYMBOL=- NUMERAL=4.0 83 ==> Disease-Class=Asthma 83 conf:(1) 362. Qualitative Concept=severe 82 ==> Disease-Class=Asthma 82 conf:(1) 363. Population Group=study population 82 ==> Disease-Class=Asthma 82 conf: (1) 364. Family Group=parent 82 ==> Disease-Class=Asthma 82 conf:(1) 365. Temporal Concept=years NUMERAL=70.0 82 ==> Disease-Class=Asthma 82 con f:(1) 366. Idea or Concept=opinion Professional or Occupational Group=investigator 8 2 ==> Disease-Class=Asthma 82 conf:(1) 367. Body Space or Junction=oral Individual Behavior=visit 82 ==> Disease-Clas s=Asthma 82 conf:(1) 368. Intellectual Product=sampling method 81 ==> Disease-Class=Asthma 81 co nf:(1) 369. Pharmacologic Substance=salbutamol 81 ==> Disease-Class=Asthma 81 conf :(1) 370. Quantitative Concept=probability sample 81 ==> Disease-Class=Asthma 81 conf:(1) 371. Intellectual Product=sampling method Quantitative Concept=probability sam ple 81 ==> Disease-Class=Asthma 81 conf:(1) 372. NUMERAL=4.0 Laboratory Procedure=screening 81 ==> Disease-Class=Asthma 81 conf:(1)

373. Therapeutic or Preventive Procedure=treatment Individual Behavior=visit 8 1 ==> Disease-Class=Asthma 81 conf:(1) 374. SYMBOL=- Quantitative Concept=short Idea or Concept=acting 81 ==> Disease -Class=Asthma 81 conf:(1) 375. SYMBOL=> UNIT=% Diagnostic Procedure=fev1 81 ==> Disease-Class=Asthma 81 conf:(1) 376. Functional Concept=evidence of 80 ==> Disease-Class=Asthma 80 conf:(1) 377. Age Group=children 80 ==> Disease-Class=Asthma 80 conf:(1) 378. Social Behavior=according 80 ==> Disease-Class=Asthma 80 conf:(1) 379. NO=not Disease or Syndrome=asthma 80 ==> Disease-Class=Asthma 80 conf: (1) 380. NUMERAL=4.0 Disease or Syndrome=asthma 80 ==> Disease-Class=Asthma 80 conf:(1) 381. Diagnostic Procedure=fev1 Individual Behavior=visit 80 ==> Disease-Class= Asthma 80 conf:(1) 382. Pharmacologic Substance=agonists 79 ==> Disease-Class=Asthma 79 conf:( 1) 383. Pharmacologic Substance=corticosteroid 79 ==> Disease-Class=Asthma 79 conf:(1) 384. Activity=taking 79 ==> Disease-Class=Asthma 79 conf:(1) 385. Temporal Concept=prior to NUMERAL=4.0 79 ==> Disease-Class=Asthma 79 c onf:(1) 386. Temporal Concept=months NUMERAL=12.0 79 ==> Disease-Class=Asthma 79 co nf:(1) 387. SYMBOL=- Body Space or Junction=oral 79 ==> Disease-Class=Asthma 79 co nf:(1) 388. SYMBOL=< Diagnostic Procedure=fev1 79 ==> Disease-Class=Asthma 79 conf :(1) 389. NUMERAL=2.0 Spatial Concept=within 79 ==> Disease-Class=Asthma 79 conf :(1) 390. Research Activity=study Laboratory Procedure=screening 79 ==> Disease-Cla ss=Asthma 79 conf:(1) 391. Research Activity=study Therapeutic or Preventive Procedure=procedures 78 ==> Disease-Class=Asthma 78 conf:(1) 392. Temporal Concept=daily 77 ==> Disease-Class=Asthma 77 conf:(1) 393. Research Activity=gina 77 ==> Disease-Class=Asthma 77 conf:(1) 394. Therapeutic or Preventive Procedure=ex 77 ==> Disease-Class=Asthma 77 conf:(1) 395. Disease or Syndrome=asthma Body Space or Junction=oral 77 ==> Disease-Cla ss=Asthma 77 conf:(1) 396. Activity=inhaled Body Space or Junction=oral 77 ==> Disease-Class=Asthma 77 conf:(1) 397. Functional Concept=start 76 ==> Disease-Class=Asthma 76 conf:(1) 398. Sign or Symptom=condition 76 ==> Disease-Class=Asthma 76 conf:(1) 399. Temporal Concept=prior to Research Activity=entry 76 ==> Disease-Class=As thma 76 conf:(1) 400. SYMBOL=> Disease or Syndrome=asthma 76 ==> Disease-Class=Asthma 76 con f:(1) 401. Spatial Concept=within Human=subjects 76 ==> Disease-Class=Asthma 76 c onf:(1) 402. Quantitative Concept=two 75 ==> Disease-Class=Asthma 75 conf:(1) 403. Laboratory or Test Result=pc20 75 ==> Disease-Class=Asthma 75 conf:(1) 404. Allergy=hypersensitivity 75 ==> Disease-Class=Asthma 75 conf:(1) 405. Temporal Concept=years Organism Attribute=female 75 ==> Disease-Class=Ast hma 75 conf:(1) 406. SYMBOL=- Organism Attribute=female 75 ==> Disease-Class=Asthma 75 conf :(1) 407. SYMBOL=>= Activity=inhaled 75 ==> Disease-Class=Asthma 75 conf:(1) 408. NUMERAL=12.0 Laboratory Procedure=screening 75 ==> Disease-Class=Asthma 7 5 conf:(1)

409. Qualitative Concept=has Human=subject 75 ==> Disease-Class=Asthma 75 c onf:(1) 410. Functional Concept=control 74 ==> Disease-Class=Asthma 74 conf:(1) 411. Research Activity=study Qualitative Concept=from 74 ==> Disease-Class=Ast hma 74 conf:(1) 412. Clinical Attribute=inability 73 ==> Disease-Class=Asthma 73 conf:(1) 413. Laboratory Procedure=test 73 ==> Disease-Class=Asthma 73 conf:(1) 414. Temporal Concept=prior to Activity=inhaled 73 ==> Disease-Class=Asthma 73 conf:(1) 415. Pharmacologic Substance=medication Disease or Syndrome=asthma 73 ==> Dise ase-Class=Asthma 73 conf:(1) 416. NUMERAL=10.0 Quantitative Concept=pack 73 ==> Disease-Class=Asthma 73 conf:(1) 417. Research Activity=study Functional Concept=participate 73 ==> Disease-Cla ss=Asthma 73 conf:(1) 418. Activity=inhaled Individual Behavior=visit 73 ==> Disease-Class=Asthma 73 conf:(1) 419. UNIT=% Diagnostic Procedure=fev1 Individual Behavior=visit 73 ==> Disease -Class=Asthma 73 conf:(1) 420. Intellectual Product=method 72 ==> Disease-Class=Asthma 72 conf:(1) 421. NO=without 72 ==> Disease-Class=Asthma 72 conf:(1) 422. NO=excluded 72 ==> Disease-Class=Asthma 72 conf:(1) 423. Quantitative Concept=equivalent 72 ==> Disease-Class=Asthma 72 conf:(1 ) 424. Functional Concept=controlled 72 ==> Disease-Class=Asthma 72 conf:(1) 425. Temporal Concept=period SYMBOL=- 72 ==> Disease-Class=Asthma 72 conf:( 1) 426. Pharmacologic Substance=agonist SYMBOL=- 72 ==> Disease-Class=Asthma 72 conf:(1) 427. SYMBOL=< UNIT=% Diagnostic Procedure=fev1 72 ==> Disease-Class=Asthma 72 conf:(1) 428. Organism Function=childbearing 71 ==> Disease-Class=Asthma 71 conf:(1) 429. SYMBOL=- Functional Concept=use of 71 ==> Disease-Class=Asthma 71 conf :(1) 430. SYMBOL=> Spatial Concept=within 71 ==> Disease-Class=Asthma 71 conf:(1 ) 431. SYMBOL=>= NUMERAL=12.0 71 ==> Disease-Class=Asthma 71 conf:(1) 432. NUMERAL=2.0 Disease or Syndrome=asthma 71 ==> Disease-Class=Asthma 71 conf:(1) 433. UNIT=% Disease or Syndrome=asthma 71 ==> Disease-Class=Asthma 71 conf: (1) 434. Idea or Concept=opinion Research Activity=study 71 ==> Disease-Class=Asth ma 71 conf:(1) 435. Qualitative Concept=regular 70 ==> Disease-Class=Asthma 70 conf:(1) 436. Intellectual Product=pack years NUMERAL=10.0 70 ==> Disease-Class=Asthma 70 conf:(1) 437. NO=not Individual Behavior=visit 70 ==> Disease-Class=Asthma 70 conf:( 1) 438. Professional or Occupational Group=medical 69 ==> Disease-Class=Asthma 69 conf:(1) 439. Temporal Concept=years Quantitative Concept=pack 69 ==> Disease-Class=Ast hma 69 conf:(1) 440. Temporal Concept=before Spatial Concept=within 69 ==> Disease-Class=Asthm a 69 conf:(1) 441. NUMERAL=12.0 Age Group=older 69 ==> Disease-Class=Asthma 69 conf:(1) 442. NUMERAL=80.0 UNIT=% 69 ==> Disease-Class=Asthma 69 conf:(1) 443. Temporal Concept=years NUMERAL=12.0 Age Group=older 69 ==> Disease-Class= Asthma 69 conf:(1) 444. Temporal Concept=prior to NUMERAL=1.0 Spatial Concept=within 69 ==> Disea se-Class=Asthma 69 conf:(1)

445. SYMBOL=- Spatial Concept=within Individual Behavior=visit 69 ==> DiseaseClass=Asthma 69 conf:(1) 446. Spatial Concept=within Disease or Syndrome=asthma Individual Behavior=vis it 69 ==> Disease-Class=Asthma 69 conf:(1) 447. Pharmacologic Substance=pef 68 ==> Disease-Class=Asthma 68 conf:(1) 448. NUMERAL=20.0 68 ==> Disease-Class=Asthma 68 conf:(1) 449. Functional Concept=increase 68 ==> Disease-Class=Asthma 68 conf:(1) 450. Contraception=birth control 68 ==> Disease-Class=Asthma 68 conf:(1) 451. Temporal Concept=years Age Group=aged 68 ==> Disease-Class=Asthma 68 c onf:(1) 452. Temporal Concept=history of SYMBOL=- 68 ==> Disease-Class=Asthma 68 co nf:(1) 453. Temporal Concept=prior to Therapeutic or Preventive Procedure=treatment 6 8 ==> Disease-Class=Asthma 68 conf:(1) 454. SYMBOL=- NUMERAL=12.0 68 ==> Disease-Class=Asthma 68 conf:(1) 455. NUMERAL=6.0 Research Activity=study 68 ==> Disease-Class=Asthma 68 con f:(1) 456. NUMERAL=2.0 Laboratory Procedure=screening 68 ==> Disease-Class=Asthma 68 conf:(1) 457. Research Activity=study Functional Concept=start 68 ==> Disease-Class=Ast hma 68 conf:(1) 458. Laboratory Procedure=screening Activity=inhaled 68 ==> Disease-Class=Asth ma 68 conf:(1) 459. Organism Function=inhalation 67 ==> Disease-Class=Asthma 67 conf:(1) 460. Immunologic Factor=allergen 67 ==> Disease-Class=Asthma 67 conf:(1) 461. Temporal Concept=days Spatial Concept=within 67 ==> Disease-Class=Asthma 67 conf:(1) 462. Pharmacologic Substance=bronchodilator UNIT=% 67 ==> Disease-Class=Asthma 67 conf:(1) 463. NO=not NUMERAL=1.0 67 ==> Disease-Class=Asthma 67 conf:(1) 464. Quantitative Concept=exacerbation Spatial Concept=within 67 ==> Disease-C lass=Asthma 67 conf:(1) 465. Disease or Syndrome=asthma Finding=life 67 ==> Disease-Class=Asthma 67 conf:(1) 466. Therapeutic or Preventive Procedure=anti 66 ==> Disease-Class=Asthma 66 conf:(1) 467. Therapeutic or Preventive Procedure=treated with 66 ==> Disease-Class=Ast hma 66 conf:(1) 468. Willing=agree 66 ==> Disease-Class=Asthma 66 conf:(1) 469. Capacity=unable 66 ==> Disease-Class=Asthma 66 conf:(1) 470. Temporal Concept=prior to Human=subject 66 ==> Disease-Class=Asthma 66 conf:(1) 471. Temporal Concept=months SYMBOL=- 66 ==> Disease-Class=Asthma 66 conf:( 1) 472. Functional Concept=use of Body Space or Junction=oral 66 ==> Disease-Clas s=Asthma 66 conf:(1) 473. Temporal Concept=weeks NUMERAL=4.0 Spatial Concept=within 66 ==> DiseaseClass=Asthma 66 conf:(1) 474. Pharmacologic Substance=corticosteroids Spatial Concept=within Body Space or Junction=oral 66 ==> Disease-Class=Asthma 66 conf:(1) 475. SYMBOL=- Disease or Syndrome=asthma Finding=life 66 ==> Disease-Class=Ast hma 66 conf:(1) 476. NUMERAL=1.0 Disease or Syndrome=asthma Individual Behavior=visit 66 ==> D isease-Class=Asthma 66 conf:(1) 477. Quantitative Concept=only 65 ==> Disease-Class=Asthma 65 conf:(1) 478. Qualitative Concept=normal 65 ==> Disease-Class=Asthma 65 conf:(1) 479. Disease or Syndrome=asthmatic 65 ==> Disease-Class=Asthma 65 conf:(1) 480. Human-caused Phenomenon or Process=safety 65 ==> Disease-Class=Asthma 65 conf:(1) 481. Compliance=comply 65 ==> Disease-Class=Asthma 65 conf:(1)

482. Patient or Disabled Group=patients Spatial Concept=within 65 ==> DiseaseClass=Asthma 65 conf:(1) 483. Temporal Concept=before Laboratory Procedure=screening 65 ==> Disease-Cla ss=Asthma 65 conf:(1) 484. NUMERAL=70.0 Age Group=ages 65 ==> Disease-Class=Asthma 65 conf:(1) 485. Idea or Concept=acting Qualitative Concept=beta 65 ==> Disease-Class=Asth ma 65 conf:(1) 486. Research Activity=study Qualitative Concept=other 65 ==> Disease-Class=As thma 65 conf:(1) 487. SYMBOL=- NUMERAL=10.0 Quantitative Concept=pack 65 ==> Disease-Class=Asth ma 65 conf:(1) 488. SYMBOL=- Idea or Concept=acting Activity=inhaled 65 ==> Disease-Class=Ast hma 65 conf:(1) 489. Qualitative Concept=clinical 64 ==> Disease-Class=Asthma 64 conf:(1) 490. Intellectual Product=sampling method SYMBOL=- 64 ==> Disease-Class=Asthma 64 conf:(1) 491. Intellectual Product=sampling method Functional Concept=non 64 ==> Diseas e-Class=Asthma 64 conf:(1) 492. SYMBOL=- Quantitative Concept=probability sample 64 ==> Disease-Class=Ast hma 64 conf:(1) 493. SYMBOL=>= Idea or Concept=predicted 64 ==> Disease-Class=Asthma 64 con f:(1) 494. Quantitative Concept=probability sample Functional Concept=non 64 ==> Dis ease-Class=Asthma 64 conf:(1) 495. Research Activity=study Activity=interfere 64 ==> Disease-Class=Asthma 64 conf:(1) 496. Temporal Concept=years SYMBOL=- Quantitative Concept=pack 64 ==> DiseaseClass=Asthma 64 conf:(1) 497. Temporal Concept=months SYMBOL=>= NUMERAL=6.0 64 ==> Disease-Class=Asthma 64 conf:(1) 498. Intellectual Product=sampling method SYMBOL=- Quantitative Concept=probab ility sample 64 ==> Disease-Class=Asthma 64 conf:(1) 499. Intellectual Product=sampling method SYMBOL=- Functional Concept=non 64 = => Disease-Class=Asthma 64 conf:(1) 500. Intellectual Product=sampling method Quantitative Concept=probability sam ple Functional Concept=non 64 ==> Disease-Class=Asthma 64 conf:(1) 501. SYMBOL=- Quantitative Concept=probability sample Functional Concept=non 6 4 ==> Disease-Class=Asthma 64 conf:(1) 502. SYMBOL=- Spatial Concept=within Laboratory Procedure=screening 64 ==> Dis ease-Class=Asthma 64 conf:(1) 503. Intellectual Product=sampling method SYMBOL=- Quantitative Concept=probab ility sample Functional Concept=non 64 ==> Disease-Class=Asthma 64 conf:(1) 504. Temporal Concept=previous 63 ==> Disease-Class=Asthma 63 conf:(1) 505. Pharmacologic Substance=drugs 63 ==> Disease-Class=Asthma 63 conf:(1) 506. Patient or Disabled Group=patient Disease or Syndrome=asthma 63 ==> Disea se-Class=Asthma 63 conf:(1) 507. Temporal Concept=prior to NUMERAL=2.0 63 ==> Disease-Class=Asthma 63 c onf:(1) 508. Pharmacologic Substance=agonist Idea or Concept=acting 63 ==> Disease-Cla ss=Asthma 63 conf:(1) 509. Laboratory Procedure=screening Body Space or Junction=oral 63 ==> Disease -Class=Asthma 63 conf:(1) 510. Temporal Concept=years SYMBOL=- Age Group=age 63 ==> Disease-Class=Asthma 63 conf:(1) 511. Temporal Concept=years NUMERAL=70.0 Age Group=ages 63 ==> Disease-Class=A sthma 63 conf:(1) 512. NUMERAL=1.0 Laboratory Procedure=screening Individual Behavior=visit 63 = => Disease-Class=Asthma 63 conf:(1) 513. NUMERAL=7.0 62 ==> Disease-Class=Asthma 62 conf:(1) 514. Qualitative Concept=uncontrolled 62 ==> Disease-Class=Asthma 62 conf:(

1) 515. Functional Concept=based 62 ==> Disease-Class=Asthma 62 conf:(1) 516. Spatial Concept=up to 62 ==> Disease-Class=Asthma 62 conf:(1) 517. Behavior Problem=smoker 62 ==> Disease-Class=Asthma 62 conf:(1) 518. Patient or Disabled Group=patients Temporal Concept=prior to 62 ==> Disea se-Class=Asthma 62 conf:(1) 519. Patient or Disabled Group=patient SYMBOL=- 62 ==> Disease-Class=Asthma 62 conf:(1) 520. Temporal Concept=years Spatial Concept=within 62 ==> Disease-Class=Asthma 62 conf:(1) 521. Pharmacologic Substance=corticosteroids Therapeutic or Preventive Procedu re=treatment 62 ==> Disease-Class=Asthma 62 conf:(1) 522. UNIT=% Spatial Concept=within 62 ==> Disease-Class=Asthma 62 conf:(1) 523. Temporal Concept=prior to Spatial Concept=within Disease or Syndrome=asth ma 62 ==> Disease-Class=Asthma 62 conf:(1) 524. Temporal Concept=prior to Disease or Syndrome=asthma Individual Behavior= visit 62 ==> Disease-Class=Asthma 62 conf:(1) 525. NUMERAL=12.0 Idea or Concept=eligible Age Group=older 62 ==> Disease-Clas s=Asthma 62 conf:(1) 526. NUMERAL=12.0 Research Activity=study Age Group=older 62 ==> Disease-Class =Asthma 62 conf:(1) 527. Temporal Concept=years NUMERAL=12.0 Idea or Concept=eligible Age Group=ol der 62 ==> Disease-Class=Asthma 62 conf:(1) 528. Temporal Concept=years NUMERAL=12.0 Research Activity=study Age Group=old er 62 ==> Disease-Class=Asthma 62 conf:(1) 529. Temporal Concept=prior to NUMERAL=1.0 Spatial Concept=within Individual B ehavior=visit 62 ==> Disease-Class=Asthma 62 conf:(1) 530. NUMERAL=12.0 Idea or Concept=eligible Research Activity=study Age Group=o lder 62 ==> Disease-Class=Asthma 62 conf:(1) 531. Temporal Concept=years NUMERAL=12.0 Idea or Concept=eligible Research Act ivity=study Age Group=older 62 ==> Disease-Class=Asthma 62 conf:(1) 532. Health Care Activity=prescribed 61 ==> Disease-Class=Asthma 61 conf:(1 ) 533. Organism Function=lactating 61 ==> Disease-Class=Asthma 61 conf:(1) 534. Temporal Concept=persistent Disease or Syndrome=asthma 61 ==> Disease-Cla ss=Asthma 61 conf:(1) 535. NO=exclusion criteria SYMBOL=- 61 ==> Disease-Class=Asthma 61 conf:(1) 536. SYMBOL=- Idea or Concept=predicted 61 ==> Disease-Class=Asthma 61 conf :(1) 537. SYMBOL=- Professional or Occupational Group=investigator 61 ==> Disease-C lass=Asthma 61 conf:(1) 538. SYMBOL=>= Quantitative Concept=one 61 ==> Disease-Class=Asthma 61 conf :(1) 539. SYMBOL=>= Research Activity=study 61 ==> Disease-Class=Asthma 61 conf: (1) 540. NUMERAL=12.0 Disease or Syndrome=asthma 61 ==> Disease-Class=Asthma 61 conf:(1) 541. Organism Attribute=female Research Activity=study 61 ==> Disease-Class=As thma 61 conf:(1) 542. Therapeutic or Preventive Procedure=treatment Laboratory Procedure=screen ing 61 ==> Disease-Class=Asthma 61 conf:(1) 543. Spatial Concept=within Body Space or Junction=oral Individual Behavior=vi sit 61 ==> Disease-Class=Asthma 61 conf:(1) 544. Temporal Concept=preceding 60 ==> Disease-Class=Asthma 60 conf:(1) 545. Intellectual Product=respiratory 60 ==> Disease-Class=Asthma 60 conf:( 1) 546. Clinical Attribute=response 60 ==> Disease-Class=Asthma 60 conf:(1) 547. Classification=b 60 ==> Disease-Class=Asthma 60 conf:(1) 548. Sign or Symptom=conditions 60 ==> Disease-Class=Asthma 60 conf:(1) 549. Manufactured Object=controller 60 ==> Disease-Class=Asthma 60 conf:(1)

550. Temporal Concept=years NUMERAL=75.0 60 ==> Disease-Class=Asthma 60 con f:(1) 551. Temporal Concept=prior to NUMERAL=12.0 60 ==> Disease-Class=Asthma 60 conf:(1) 552. Temporal Concept=weeks Disease or Syndrome=asthma 60 ==> Disease-Class=As thma 60 conf:(1) 553. Temporal Concept=months Qualitative Concept=last 60 ==> Disease-Class=Ast hma 60 conf:(1) 554. Pharmacologic Substance=bronchodilator Diagnostic Procedure=fev1 60 ==> D isease-Class=Asthma 60 conf:(1) 555. SYMBOL=- Therapeutic or Preventive Procedure=anti 60 ==> Disease-Class=As thma 60 conf:(1) 556. SYMBOL=- Functional Concept=use 60 ==> Disease-Class=Asthma 60 conf:(1 ) 557. NUMERAL=2.0 Individual Behavior=visit 60 ==> Disease-Class=Asthma 60 c onf:(1) 558. Quantitative Concept=baseline UNIT=% 60 ==> Disease-Class=Asthma 60 co nf:(1) 559. Qualitative Concept=beta Activity=inhaled 60 ==> Disease-Class=Asthma 60 conf:(1) 560. Individual Behavior=visit Human=subjects 60 ==> Disease-Class=Asthma 60 conf:(1) 561. Temporal Concept=years SYMBOL=- NUMERAL=10.0 60 ==> Disease-Class=Asthma 60 conf:(1) 562. Temporal Concept=months NUMERAL=3.0 Spatial Concept=within 60 ==> Disease -Class=Asthma 60 conf:(1) 563. SYMBOL=>= UNIT=% Idea or Concept=predicted 60 ==> Disease-Class=Asthma 60 conf:(1) 564. Temporal Concept=reversibility 59 ==> Disease-Class=Asthma 59 conf:(1) 565. Organization=laboratory 59 ==> Disease-Class=Asthma 59 conf:(1) 566. NUMERAL=70.0 Research Activity=study 59 ==> Disease-Class=Asthma 59 co nf:(1) 567. Functional Concept=requiring Disease or Syndrome=asthma 59 ==> Disease-Cl ass=Asthma 59 conf:(1) 568. Temporal Concept=history 58 ==> Disease-Class=Asthma 58 conf:(1) 569. NUMERAL=55.0 58 ==> Disease-Class=Asthma 58 conf:(1) 570. Qualitative Concept=negative 58 ==> Disease-Class=Asthma 58 conf:(1) 571. Qualitative Concept=related 58 ==> Disease-Class=Asthma 58 conf:(1) 572. Body Substance=serum 58 ==> Disease-Class=Asthma 58 conf:(1) 573. Health Care Activity=hospitalization Disease or Syndrome=asthma 58 ==> Di sease-Class=Asthma 58 conf:(1) 574. Temporal Concept=prior to NUMERAL=6.0 58 ==> Disease-Class=Asthma 58 c onf:(1) 575. Temporal Concept=weeks Individual Behavior=visit 58 ==> Disease-Class=Ast hma 58 conf:(1) 576. Temporal Concept=year NUMERAL=1.0 58 ==> Disease-Class=Asthma 58 conf: (1) 577. Temporal Concept=before Individual Behavior=visit 58 ==> Disease-Class=As thma 58 conf:(1) 578. Pharmacologic Substance=corticosteroids Disease or Syndrome=asthma 58 ==> Disease-Class=Asthma 58 conf:(1) 579. Pharmacologic Substance=corticosteroids Individual Behavior=visit 58 ==> Disease-Class=Asthma 58 conf:(1) 580. SYMBOL=< Idea or Concept=predicted 58 ==> Disease-Class=Asthma 58 conf :(1) 581. NUMERAL=5.0 Spatial Concept=within 58 ==> Disease-Class=Asthma 58 conf :(1) 582. NUMERAL=70.0 Idea or Concept=eligible 58 ==> Disease-Class=Asthma 58 c onf:(1) 583. Disease or Syndrome=asthma Diagnostic Procedure=fev1 58 ==> Disease-Class

=Asthma 58 conf:(1) 584. Laboratory Procedure=screening Human=subjects 58 ==> Disease-Class=Asthma 58 conf:(1) 585. Temporal Concept=years NUMERAL=70.0 Idea or Concept=eligible 58 ==> Disea se-Class=Asthma 58 conf:(1) 586. Temporal Concept=years NUMERAL=70.0 Research Activity=study 58 ==> Diseas e-Class=Asthma 58 conf:(1) 587. Temporal Concept=prior to SYMBOL=>= Laboratory Procedure=screening 58 ==> Disease-Class=Asthma 58 conf:(1) 588. SYMBOL=>= Idea or Concept=predicted Diagnostic Procedure=fev1 58 ==> Dise ase-Class=Asthma 58 conf:(1) 589. NUMERAL=70.0 Idea or Concept=eligible Research Activity=study 58 ==> Dise ase-Class=Asthma 58 conf:(1) 590. NUMERAL=70.0 Idea or Concept=eligible Age Group=ages 58 ==> Disease-Class =Asthma 58 conf:(1) 591. NUMERAL=70.0 Research Activity=study Age Group=ages 58 ==> Disease-Class= Asthma 58 conf:(1) 592. Temporal Concept=years NUMERAL=70.0 Idea or Concept=eligible Research Act ivity=study 58 ==> Disease-Class=Asthma 58 conf:(1) 593. Temporal Concept=years NUMERAL=70.0 Idea or Concept=eligible Age Group=ag es 58 ==> Disease-Class=Asthma 58 conf:(1) 594. Temporal Concept=years NUMERAL=70.0 Research Activity=study Age Group=age s 58 ==> Disease-Class=Asthma 58 conf:(1) 595. NUMERAL=70.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 58 ==> Disease-Class=Asthma 58 conf:(1) 596. Temporal Concept=years NUMERAL=70.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 58 ==> Disease-Class=Asthma 58 conf:(1) 597. Qualitative Concept=potential 57 ==> Disease-Class=Asthma 57 conf:(1) 598. Pharmacologic Substance=agonists SYMBOL=- 57 ==> Disease-Class=Asthma 57 conf:(1) 599. SYMBOL=- NUMERAL=6.0 57 ==> Disease-Class=Asthma 57 conf:(1) 600. SYMBOL=- Quantitative Concept=dose 57 ==> Disease-Class=Asthma 57 conf :(1) 601. Research Activity=study Therapeutic or Preventive Procedure=treatment 57 ==> Disease-Class=Asthma 57 conf:(1) 602. Qualitative Concept=last Disease or Syndrome=asthma 57 ==> Disease-Class= Asthma 57 conf:(1) 603. Professional or Occupational Group=investigator Human=subject 57 ==> Dise ase-Class=Asthma 57 conf:(1) 604. Temporal Concept=prior to Research Activity=study Spatial Concept=within 57 ==> Disease-Class=Asthma 57 conf:(1) 605. Pharmacologic Substance=bronchodilator UNIT=% Diagnostic Procedure=fev1 5 7 ==> Disease-Class=Asthma 57 conf:(1) 606. NO=not Research Activity=study Human=subject 57 ==> Disease-Class=Asthma 57 conf:(1) 607. SYMBOL=- UNIT=% Idea or Concept=predicted 57 ==> Disease-Class=Asthma 57 conf:(1) 608. Temporal Concept=duration 56 ==> Disease-Class=Asthma 56 conf:(1) 609. Qualitative Concept=inclusion 56 ==> Disease-Class=Asthma 56 conf:(1) 610. Functional Concept=due to 56 ==> Disease-Class=Asthma 56 conf:(1) 611. Body Location or Region=hepatic 56 ==> Disease-Class=Asthma 56 conf:(1 ) 612. Regulation or Law=consent 56 ==> Disease-Class=Asthma 56 conf:(1) 613. Mental or Behavioral Dysfunction=mdi 56 ==> Disease-Class=Asthma 56 co nf:(1) 614. Temporal Concept=period Research Activity=study 56 ==> Disease-Class=Asth ma 56 conf:(1) 615. Pharmacologic Substance=steroids Activity=inhaled 56 ==> Disease-Class=As thma 56 conf:(1) 616. NO=not Spatial Concept=within 56 ==> Disease-Class=Asthma 56 conf:(1)

617. SYMBOL=> Idea or Concept=predicted 56 ==> Disease-Class=Asthma 56 conf :(1) 618. SYMBOL=> Individual Behavior=visit 56 ==> Disease-Class=Asthma 56 conf :(1) 619. NUMERAL=3.0 Individual Behavior=visit 56 ==> Disease-Class=Asthma 56 c onf:(1) 620. Research Activity=entry Spatial Concept=within 56 ==> Disease-Class=Asthm a 56 conf:(1) 621. Research Activity=gina Disease or Syndrome=asthma 56 ==> Disease-Class=As thma 56 conf:(1) 622. Temporal Concept=weeks Spatial Concept=within Individual Behavior=visit 5 6 ==> Disease-Class=Asthma 56 conf:(1) 623. Temporal Concept=months SYMBOL=>= Disease or Syndrome=asthma 56 ==> Disea se-Class=Asthma 56 conf:(1) 624. SYMBOL=< UNIT=% Idea or Concept=predicted 56 ==> Disease-Class=Asthma 56 conf:(1) 625. Quantitative Concept=kg 55 ==> Disease-Class=Asthma 55 conf:(1) 626. Therapeutic or Preventive Procedure=presence of 55 ==> Disease-Class=Asth ma 55 conf:(1) 627. Temporal Concept=years NUMERAL=60.0 55 ==> Disease-Class=Asthma 55 con f:(1) 628. Intellectual Product=pack years Finding=smoking history 55 ==> Disease-Cl ass=Asthma 55 conf:(1) 629. SYMBOL=- NUMERAL=5.0 55 ==> Disease-Class=Asthma 55 conf:(1) 630. SYMBOL=>= NUMERAL=3.0 55 ==> Disease-Class=Asthma 55 conf:(1) 631. NUMERAL=1.0 Body Space or Junction=oral 55 ==> Disease-Class=Asthma 55 conf:(1) 632. Quantitative Concept=baseline Diagnostic Procedure=fev1 55 ==> Disease-Cl ass=Asthma 55 conf:(1) 633. Idea or Concept=acting Disease or Syndrome=asthma 55 ==> Disease-Class=As thma 55 conf:(1) 634. Therapeutic or Preventive Procedure=treatment Body Space or Junction=oral 55 ==> Disease-Class=Asthma 55 conf:(1) 635. SYMBOL=- NUMERAL=1.0 Individual Behavior=visit 55 ==> Disease-Class=Asthm a 55 conf:(1) 636. Temporal Concept=prior to Spatial Concept=within Laboratory Procedure=scr eening Individual Behavior=visit 55 ==> Disease-Class=Asthma 55 conf:(1) 637. SYMBOL=>= UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 55 = => Disease-Class=Asthma 55 conf:(1) 638. Temporal Concept=concomitant 54 ==> Disease-Class=Asthma 54 conf:(1) 639. Intellectual Product=methods 54 ==> Disease-Class=Asthma 54 conf:(1) 640. NUMERAL=15.0 54 ==> Disease-Class=Asthma 54 conf:(1) 641. Quantitative Concept=value 54 ==> Disease-Class=Asthma 54 conf:(1) 642. Spatial Concept=over 54 ==> Disease-Class=Asthma 54 conf:(1) 643. Disease or Syndrome=copd 54 ==> Disease-Class=Asthma 54 conf:(1) 644. Laboratory Procedure=testing 54 ==> Disease-Class=Asthma 54 conf:(1) 645. MARK=& 54 ==> Disease-Class=Asthma 54 conf:(1) 646. Patient or Disabled Group=patients NO=not 54 ==> Disease-Class=Asthma 54 conf:(1) 647. SYMBOL=> Laboratory Procedure=screening 54 ==> Disease-Class=Asthma 54 conf:(1) 648. NUMERAL=70.0 UNIT=% 54 ==> Disease-Class=Asthma 54 conf:(1) 649. Quantitative Concept=baseline Laboratory Procedure=screening 54 ==> Disea se-Class=Asthma 54 conf:(1) 650. Temporal Concept=years NUMERAL=10.0 Quantitative Concept=pack 54 ==> Dise ase-Class=Asthma 54 conf:(1) 651. Temporal Concept=months NUMERAL=6.0 Disease or Syndrome=asthma 54 ==> Dis ease-Class=Asthma 54 conf:(1) 652. SYMBOL=- Spatial Concept=within Disease or Syndrome=asthma 54 ==> Disease -Class=Asthma 54 conf:(1)

653. SYMBOL=> UNIT=% Idea or Concept=predicted 54 ==> Disease-Class=Asthma 54 conf:(1) 654. NUMERAL=1.0 Spatial Concept=within Laboratory Procedure=screening 54 ==> Disease-Class=Asthma 54 conf:(1) 655. NUMERAL=14.0 53 ==> Disease-Class=Asthma 53 conf:(1) 656. Disease or Syndrome=lower respiratory tract infection 53 ==> Disease-Clas s=Asthma 53 conf:(1) 657. Health Care Activity=diagnosis SYMBOL=>= 53 ==> Disease-Class=Asthma 53 conf:(1) 658. Temporal Concept=before Research Activity=study 53 ==> Disease-Class=Asth ma 53 conf:(1) 659. SYMBOL=- Functional Concept=including 53 ==> Disease-Class=Asthma 53 c onf:(1) 660. NUMERAL=80.0 Idea or Concept=predicted 53 ==> Disease-Class=Asthma 53 conf:(1) 661. Research Activity=study Willing=willing 53 ==> Disease-Class=Asthma 53 conf:(1) 662. Research Activity=study Capacity=able to 53 ==> Disease-Class=Asthma 53 conf:(1) 663. SYMBOL=>= NUMERAL=6.0 Disease or Syndrome=asthma 53 ==> Disease-Class=Ast hma 53 conf:(1) 664. NUMERAL=1.0 Spatial Concept=within Disease or Syndrome=asthma 53 ==> Dise ase-Class=Asthma 53 conf:(1) 665. NUMERAL=80.0 UNIT=% Idea or Concept=predicted 53 ==> Disease-Class=Asthma 53 conf:(1) 666. Idea or Concept=opinion Research Activity=study Professional or Occupatio nal Group=investigator 53 ==> Disease-Class=Asthma 53 conf:(1) 667. Temporal Concept=years SYMBOL=- NUMERAL=10.0 Quantitative Concept=pack 53 ==> Disease-Class=Asthma 53 conf:(1) 668. Disease or Syndrome=infection 52 ==> Disease-Class=Asthma 52 conf:(1) 669. Disease or Syndrome=respiratory tract infection 52 ==> Disease-Class=Asth ma 52 conf:(1) 670. Patient or Disabled Group=patients SYMBOL=>= 52 ==> Disease-Class=Asthma 52 conf:(1) 671. Temporal Concept=prior to NUMERAL=3.0 52 ==> Disease-Class=Asthma 52 c onf:(1) 672. Pharmacologic Substance=medication SYMBOL=- 52 ==> Disease-Class=Asthma 5 2 conf:(1) 673. Pharmacologic Substance=drug Research Activity=study 52 ==> Disease-Class =Asthma 52 conf:(1) 674. SYMBOL=- NUMERAL=3.0 52 ==> Disease-Class=Asthma 52 conf:(1) 675. SYMBOL=- Qualitative Concept=pre 52 ==> Disease-Class=Asthma 52 conf:( 1) 676. Laboratory or Test Result=pc20 Organic Chemical=methacholine 52 ==> Disea se-Class=Asthma 52 conf:(1) 677. UNIT=% Functional Concept=increase 52 ==> Disease-Class=Asthma 52 conf :(1) 678. Research Activity=study Functional Concept=use 52 ==> Disease-Class=Asthm a 52 conf:(1) 679. SYMBOL=< Idea or Concept=predicted Diagnostic Procedure=fev1 52 ==> Disea se-Class=Asthma 52 conf:(1) 680. NUMERAL=1.0 Research Activity=study Individual Behavior=visit 52 ==> Dise ase-Class=Asthma 52 conf:(1) 681. Quantitative Concept=exacerbation Spatial Concept=within Disease or Syndr ome=asthma 52 ==> Disease-Class=Asthma 52 conf:(1) 682. Temporal Concept=week 51 ==> Disease-Class=Asthma 51 conf:(1) 683. Pharmacologic Substance=investigational drug 51 ==> Disease-Class=Asthma 51 conf:(1) 684. NUMERAL=90.0 51 ==> Disease-Class=Asthma 51 conf:(1) 685. Functional Concept=provide 51 ==> Disease-Class=Asthma 51 conf:(1)

686. Social Behavior=allowed 51 ==> Disease-Class=Asthma 51 conf:(1) 687. Allergy=allergic 51 ==> Disease-Class=Asthma 51 conf:(1) 688. Patient or Disabled Group=patient Qualitative Concept=has 51 ==> DiseaseClass=Asthma 51 conf:(1) 689. Temporal Concept=prior to Functional Concept=use of 51 ==> Disease-Class= Asthma 51 conf:(1) 690. Temporal Concept=prior to Body Space or Junction=oral 51 ==> Disease-Clas s=Asthma 51 conf:(1) 691. Temporal Concept=prior to Human=subjects 51 ==> Disease-Class=Asthma 51 conf:(1) 692. Temporal Concept=weeks Body Space or Junction=oral 51 ==> Disease-Class=A sthma 51 conf:(1) 693. SYMBOL=- Organism Attribute=females 51 ==> Disease-Class=Asthma 51 con f:(1) 694. NUMERAL=4.0 Individual Behavior=visit 51 ==> Disease-Class=Asthma 51 c onf:(1) 695. NUMERAL=3.0 Laboratory Procedure=screening 51 ==> Disease-Class=Asthma 51 conf:(1) 696. NUMERAL=75.0 Age Group=ages 51 ==> Disease-Class=Asthma 51 conf:(1) 697. Idea or Concept=predicted Individual Behavior=visit 51 ==> Disease-Class= Asthma 51 conf:(1) 698. Temporal Concept=prior to Disease or Syndrome=asthma Laboratory Procedure =screening 51 ==> Disease-Class=Asthma 51 conf:(1) 699. SYMBOL=- Research Activity=study Human=subject 51 ==> Disease-Class=Asthm a 51 conf:(1) 700. NUMERAL=4.0 Spatial Concept=within Laboratory Procedure=screening 51 ==> Disease-Class=Asthma 51 conf:(1) 701. Disease or Syndrome=asthma Laboratory Procedure=screening Individual Beha vior=visit 51 ==> Disease-Class=Asthma 51 conf:(1) 702. Clinical Attribute=parenteral 50 ==> Disease-Class=Asthma 50 conf:(1) 703. Health Care Related Organization=emergency room 50 ==> Disease-Class=Asth ma 50 conf:(1) 704. Temporal Concept=after UNIT=% 50 ==> Disease-Class=Asthma 50 conf:(1) 705. Temporal Concept=prior to Pharmacologic Substance=medication 50 ==> Disea se-Class=Asthma 50 conf:(1) 706. SYMBOL=- Behavior Problem=smokers 50 ==> Disease-Class=Asthma 50 conf: (1) 707. NUMERAL=75.0 Research Activity=study 50 ==> Disease-Class=Asthma 50 co nf:(1) 708. NUMERAL=80.0 Diagnostic Procedure=fev1 50 ==> Disease-Class=Asthma 50 conf:(1) 709. NUMERAL=60.0 Research Activity=study 50 ==> Disease-Class=Asthma 50 co nf:(1) 710. Quantitative Concept=dose Research Activity=study 50 ==> Disease-Class=As thma 50 conf:(1) 711. Research Activity=study Body Space or Junction=oral 50 ==> Disease-Class= Asthma 50 conf:(1) 712. Qualitative Concept=has Spatial Concept=within 50 ==> Disease-Class=Asthm a 50 conf:(1) 713. NUMERAL=80.0 UNIT=% Diagnostic Procedure=fev1 50 ==> Disease-Class=Asthma 50 conf:(1) 714. SYMBOL=< UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 50 == > Disease-Class=Asthma 50 conf:(1) 715. Quantitative Concept=can 49 ==> Disease-Class=Asthma 49 conf:(1) 716. Quantitative Concept=puffs 49 ==> Disease-Class=Asthma 49 conf:(1) 717. Functional Concept=inclusive 49 ==> Disease-Class=Asthma 49 conf:(1) 718. Allergy=sensitivity 49 ==> Disease-Class=Asthma 49 conf:(1) 719. Patient or Disabled Group=patients Laboratory Procedure=screening 49 ==> Disease-Class=Asthma 49 conf:(1) 720. Temporal Concept=days NUMERAL=30.0 49 ==> Disease-Class=Asthma 49 conf

:(1) 721. Clinical Attribute=parenteral Body Space or Junction=oral 49 ==> DiseaseClass=Asthma 49 conf:(1) 722. Pharmacologic Substance=corticosteroids Functional Concept=systemic 49 == > Disease-Class=Asthma 49 conf:(1) 723. SYMBOL=>= NUMERAL=2.0 49 ==> Disease-Class=Asthma 49 conf:(1) 724. SYMBOL=>= Human=subjects 49 ==> Disease-Class=Asthma 49 conf:(1) 725. NUMERAL=3.0 Qualitative Concept=last 49 ==> Disease-Class=Asthma 49 co nf:(1) 726. NUMERAL=1.0 UNIT=% 49 ==> Disease-Class=Asthma 49 conf:(1) 727. Idea or Concept=acting Individual Behavior=visit 49 ==> Disease-Class=Ast hma 49 conf:(1) 728. Functional Concept=systemic Spatial Concept=within 49 ==> Disease-Class=A sthma 49 conf:(1) 729. Temporal Concept=years NUMERAL=75.0 Age Group=ages 49 ==> Disease-Class=A sthma 49 conf:(1) 730. SYMBOL=- Research Activity=study Spatial Concept=within 49 ==> Disease-Cl ass=Asthma 49 conf:(1) 731. UNIT=% Disease or Syndrome=asthma Diagnostic Procedure=fev1 49 ==> Diseas e-Class=Asthma 49 conf:(1) 732. Qualitative Concept=total 48 ==> Disease-Class=Asthma 48 conf:(1) 733. Qualitative Concept=relevant 48 ==> Disease-Class=Asthma 48 conf:(1) 734. Qualitative Concept=received 48 ==> Disease-Class=Asthma 48 conf:(1) 735. Disease or Syndrome=diseases 48 ==> Disease-Class=Asthma 48 conf:(1) 736. Patient or Disabled Group=patients SYMBOL=> 48 ==> Disease-Class=Asthma 4 8 conf:(1) 737. Temporal Concept=years SYMBOL=>= 48 ==> Disease-Class=Asthma 48 conf:( 1) 738. Temporal Concept=years NUMERAL=5.0 48 ==> Disease-Class=Asthma 48 conf :(1) 739. Temporal Concept=year Spatial Concept=within 48 ==> Disease-Class=Asthma 48 conf:(1) 740. Temporal Concept=period Sign or Symptom=run 48 ==> Disease-Class=Asthma 4 8 conf:(1) 741. Temporal Concept=day SYMBOL=- 48 ==> Disease-Class=Asthma 48 conf:(1) 742. Pharmacologic Substance=steroids Body Space or Junction=oral 48 ==> Disea se-Class=Asthma 48 conf:(1) 743. SYMBOL=- Therapeutic or Preventive Procedure=therapy 48 ==> Disease-Class =Asthma 48 conf:(1) 744. NUMERAL=6.0 Laboratory Procedure=screening 48 ==> Disease-Class=Asthma 48 conf:(1) 745. NUMERAL=1.0 Human=subject 48 ==> Disease-Class=Asthma 48 conf:(1) 746. NUMERAL=60.0 UNIT=% 48 ==> Disease-Class=Asthma 48 conf:(1) 747. Quantitative Concept=one Spatial Concept=within 48 ==> Disease-Class=Asth ma 48 conf:(1) 748. Quantitative Concept=ml Laboratory or Test Result=pc20 48 ==> Disease-Cla ss=Asthma 48 conf:(1) 749. Functional Concept=control Disease or Syndrome=asthma 48 ==> Disease-Clas s=Asthma 48 conf:(1) 750. Functional Concept=increase Diagnostic Procedure=fev1 48 ==> Disease-Clas s=Asthma 48 conf:(1) 751. UNIT=% Laboratory Procedure=screening Individual Behavior=visit 48 ==> Di sease-Class=Asthma 48 conf:(1) 752. Health Care Activity=meet 47 ==> Disease-Class=Asthma 47 conf:(1) 753. Spatial Concept=up 47 ==> Disease-Class=Asthma 47 conf:(1) 754. Sign or Symptom=signed 47 ==> Disease-Class=Asthma 47 conf:(1) 755. Diagnostic Procedure=methacholine challenge 47 ==> Disease-Class=Asthma 4 7 conf:(1) 756. Diagnostic Procedure=spirometry 47 ==> Disease-Class=Asthma 47 conf:(1 )

757. Patient or Disabled Group=patients Temporal Concept=years 47 ==> DiseaseClass=Asthma 47 conf:(1) 758. Patient or Disabled Group=patients NUMERAL=1.0 47 ==> Disease-Class=Asthm a 47 conf:(1) 759. Health Care Activity=diagnosis Professional or Occupational Group=physici an 47 ==> Disease-Class=Asthma 47 conf:(1) 760. Temporal Concept=months Body Space or Junction=oral 47 ==> Disease-Class= Asthma 47 conf:(1) 761. SYMBOL=- Qualitative Concept=other 47 ==> Disease-Class=Asthma 47 conf :(1) 762. SYMBOL=- Finding=smoking history 47 ==> Disease-Class=Asthma 47 conf:( 1) 763. SYMBOL=>= Spatial Concept=within 47 ==> Disease-Class=Asthma 47 conf:( 1) 764. NUMERAL=10.0 Spatial Concept=within 47 ==> Disease-Class=Asthma 47 con f:(1) 765. NUMERAL=12.0 UNIT=% 47 ==> Disease-Class=Asthma 47 conf:(1) 766. NUMERAL=75.0 Idea or Concept=eligible 47 ==> Disease-Class=Asthma 47 c onf:(1) 767. UNIT=% Qualitative Concept=pre 47 ==> Disease-Class=Asthma 47 conf:(1) 768. Research Activity=study Functional Concept=use of 47 ==> Disease-Class=As thma 47 conf:(1) 769. Research Activity=study Regulation or Law=informed consent 47 ==> Disease -Class=Asthma 47 conf:(1) 770. Functional Concept=controlled Disease or Syndrome=asthma 47 ==> Disease-C lass=Asthma 47 conf:(1) 771. Temporal Concept=years NUMERAL=75.0 Idea or Concept=eligible 47 ==> Disea se-Class=Asthma 47 conf:(1) 772. Temporal Concept=years NUMERAL=75.0 Research Activity=study 47 ==> Diseas e-Class=Asthma 47 conf:(1) 773. NO=not NUMERAL=1.0 Individual Behavior=visit 47 ==> Disease-Class=Asthma 47 conf:(1) 774. SYMBOL=- Idea or Concept=predicted Diagnostic Procedure=fev1 47 ==> Disea se-Class=Asthma 47 conf:(1) 775. NUMERAL=75.0 Idea or Concept=eligible Research Activity=study 47 ==> Dise ase-Class=Asthma 47 conf:(1) 776. NUMERAL=75.0 Idea or Concept=eligible Age Group=ages 47 ==> Disease-Class =Asthma 47 conf:(1) 777. NUMERAL=75.0 Research Activity=study Age Group=ages 47 ==> Disease-Class= Asthma 47 conf:(1) 778. Quantitative Concept=baseline UNIT=% Diagnostic Procedure=fev1 47 ==> Dis ease-Class=Asthma 47 conf:(1) 779. UNIT=% Idea or Concept=predicted Individual Behavior=visit 47 ==> Disease -Class=Asthma 47 conf:(1) 780. Temporal Concept=years NUMERAL=75.0 Idea or Concept=eligible Research Act ivity=study 47 ==> Disease-Class=Asthma 47 conf:(1) 781. Temporal Concept=years NUMERAL=75.0 Idea or Concept=eligible Age Group=ag es 47 ==> Disease-Class=Asthma 47 conf:(1) 782. Temporal Concept=years NUMERAL=75.0 Research Activity=study Age Group=age s 47 ==> Disease-Class=Asthma 47 conf:(1) 783. NUMERAL=75.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 47 ==> Disease-Class=Asthma 47 conf:(1) 784. Temporal Concept=years NUMERAL=75.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 47 ==> Disease-Class=Asthma 47 conf:(1) 785. Temporal Concept=at the time 46 ==> Disease-Class=Asthma 46 conf:(1) 786. Qualitative Concept=long 46 ==> Disease-Class=Asthma 46 conf:(1) 787. Qualitative Concept=complete 46 ==> Disease-Class=Asthma 46 conf:(1) 788. Qualitative Concept=perform 46 ==> Disease-Class=Asthma 46 conf:(1) 789. Therapeutic or Preventive Procedure=intubation 46 ==> Disease-Class=Asthm a 46 conf:(1)

790. Activity=maintenance 46 ==> Disease-Class=Asthma 46 conf:(1) 791. Temporal Concept=weeks SYMBOL=- 46 ==> Disease-Class=Asthma 46 )

conf:(1

792. Temporal Concept=month Spatial Concept=within 46 ==> Disease-Class=Asthma 46 conf:(1) 793. Temporal Concept=day Research Activity=study 46 ==> Disease-Class=Asthma 46 conf:(1) 794. Pharmacologic Substance=corticosteroid Activity=inhaled 46 ==> Disease-Cl ass=Asthma 46 conf:(1) 795. Quantitative Concept=value UNIT=% 46 ==> Disease-Class=Asthma 46 conf: (1) 796. Functional Concept=use of Disease or Syndrome=asthma 46 ==> Disease-Class =Asthma 46 conf:(1) 797. Professional or Occupational Group=physician Diagnostic Procedure=diagnos ed 46 ==> Disease-Class=Asthma 46 conf:(1) 798. Professional or Occupational Group=investigator Individual Behavior=parti cipation 46 ==> Disease-Class=Asthma 46 conf:(1) 799. Temporal Concept=prior to SYMBOL=- Laboratory Procedure=screening 46 ==> Disease-Class=Asthma 46 conf:(1) 800. Temporal Concept=prior to SYMBOL=- Individual Behavior=visit 46 ==> Disea se-Class=Asthma 46 conf:(1) 801. SYMBOL=> Idea or Concept=predicted Diagnostic Procedure=fev1 46 ==> Disea se-Class=Asthma 46 conf:(1) 802. SYMBOL=- UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 46 == > Disease-Class=Asthma 46 conf:(1) 803. NUMERAL=11.0 45 ==> Disease-Class=Asthma 45 conf:(1) 804. Idea or Concept=exception 45 ==> Disease-Class=Asthma 45 conf:(1) 805. Age Group=old 45 ==> Disease-Class=Asthma 45 conf:(1) 806. Language=english 45 ==> Disease-Class=Asthma 45 conf:(1) 807. Patient or Disabled Group=patients Organism Attribute=female 45 ==> Disea se-Class=Asthma 45 conf:(1) 808. Patient or Disabled Group=patient Spatial Concept=within 45 ==> Disease-C lass=Asthma 45 conf:(1) 809. Temporal Concept=years NUMERAL=55.0 45 ==> Disease-Class=Asthma 45 con f:(1) 810. Temporal Concept=years Spatial Concept=between 45 ==> Disease-Class=Asthm a 45 conf:(1) 811. Temporal Concept=years Disease or Syndrome=asthma 45 ==> Disease-Class=As thma 45 conf:(1) 812. Temporal Concept=weeks Qualitative Concept=last 45 ==> Disease-Class=Asth ma 45 conf:(1) 813. Pharmacologic Substance=agonists Idea or Concept=acting 45 ==> Disease-Cl ass=Asthma 45 conf:(1) 814. NO=no SYMBOL=- 45 ==> Disease-Class=Asthma 45 conf:(1) 815. SYMBOL=- Qualitative Concept=significant 45 ==> Disease-Class=Asthma 45 conf:(1) 816. NUMERAL=2.0 Research Activity=study 45 ==> Disease-Class=Asthma 45 con f:(1) 817. NUMERAL=1.0 Therapeutic or Preventive Procedure=treatment 45 ==> DiseaseClass=Asthma 45 conf:(1) 818. NUMERAL=70.0 Diagnostic Procedure=fev1 45 ==> Disease-Class=Asthma 45 conf:(1) 819. NUMERAL=60.0 Diagnostic Procedure=fev1 45 ==> Disease-Class=Asthma 45 conf:(1) 820. Quantitative Concept=all Research Activity=study 45 ==> Disease-Class=Ast hma 45 conf:(1) 821. Idea or Concept=acting Laboratory Procedure=screening 45 ==> Disease-Clas s=Asthma 45 conf:(1) 822. Functional Concept=use Spatial Concept=within 45 ==> Disease-Class=Asthma 45 conf:(1)

823. Temporal Concept=period SYMBOL=- Sign or Symptom=run 45 ==> Disease-Class =Asthma 45 conf:(1) 824. UNIT=% Functional Concept=increase Diagnostic Procedure=fev1 45 ==> Disea se-Class=Asthma 45 conf:(1) 825. Health Care Activity=physical examination 44 ==> Disease-Class=Asthma 44 conf:(1) 826. Health Care Activity=challenge 44 ==> Disease-Class=Asthma 44 conf:(1) 827. Pharmacologic Substance=steroid 44 ==> Disease-Class=Asthma 44 conf:(1 ) 828. Qualitative Concept=minimum 44 ==> Disease-Class=Asthma 44 conf:(1) 829. Therapeutic or Preventive Procedure=rescue 44 ==> Disease-Class=Asthma 44 conf:(1) 830. Finding=medical history 44 ==> Disease-Class=Asthma 44 conf:(1) 831. Biologically Active Substance=leukotriene 44 ==> Disease-Class=Asthma 44 conf:(1) 832. Diagnostic Procedure=ecg 44 ==> Disease-Class=Asthma 44 conf:(1) 833. Patient or Disabled Group=patient Individual Behavior=visit 44 ==> Diseas e-Class=Asthma 44 conf:(1) 834. Health Care Activity=documented UNIT=% 44 ==> Disease-Class=Asthma 44 conf:(1) 835. Temporal Concept=years NUMERAL=50.0 44 ==> Disease-Class=Asthma 44 con f:(1) 836. Temporal Concept=prior to Pharmacologic Substance=corticosteroids 44 ==> Disease-Class=Asthma 44 conf:(1) 837. Temporal Concept=months Research Activity=study 44 ==> Disease-Class=Asth ma 44 conf:(1) 838. Intellectual Product=pack years SYMBOL=> 44 ==> Disease-Class=Asthma 44 conf:(1) 839. Intellectual Product=guidelines Disease or Syndrome=asthma 44 ==> Disease -Class=Asthma 44 conf:(1) 840. Pharmacologic Substance=albuterol UNIT=% 44 ==> Disease-Class=Asthma 44 conf:(1) 841. NO=not Human=subjects 44 ==> Disease-Class=Asthma 44 conf:(1) 842. SYMBOL=- Functional Concept=requiring 44 ==> Disease-Class=Asthma 44 c onf:(1) 843. SYMBOL=- Age Group=aged 44 ==> Disease-Class=Asthma 44 conf:(1) 844. SYMBOL=- Diagnostic Procedure=diagnosed 44 ==> Disease-Class=Asthma 44 conf:(1) 845. Quantitative Concept=ml Organic Chemical=methacholine 44 ==> Disease-Clas s=Asthma 44 conf:(1) 846. Organism Attribute=female Age Group=age 44 ==> Disease-Class=Asthma 44 conf:(1) 847. Research Activity=study Activity=inhaled 44 ==> Disease-Class=Asthma 44 conf:(1) 848. Qualitative Concept=has Disease or Syndrome=asthma 44 ==> Disease-Class=A sthma 44 conf:(1) 849. Health Care Activity=diagnosis SYMBOL=>= Disease or Syndrome=asthma 44 == > Disease-Class=Asthma 44 conf:(1) 850. Temporal Concept=prior to SYMBOL=- Spatial Concept=within 44 ==> DiseaseClass=Asthma 44 conf:(1) 851. NUMERAL=70.0 UNIT=% Diagnostic Procedure=fev1 44 ==> Disease-Class=Asthma 44 conf:(1) 852. NUMERAL=60.0 UNIT=% Diagnostic Procedure=fev1 44 ==> Disease-Class=Asthma 44 conf:(1) 853. SYMBOL=> UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 44 == > Disease-Class=Asthma 44 conf:(1) 854. Health Care Activity=apply 43 ==> Disease-Class=Asthma 43 conf:(1) 855. Health Care Activity=enrolled 43 ==> Disease-Class=Asthma 43 conf:(1) 856. Temporal Concept=hours 43 ==> Disease-Class=Asthma 43 conf:(1) 857. Quantitative Concept=present 43 ==> Disease-Class=Asthma 43 conf:(1)

858. Qualitative Concept=investigational 43 ==> Disease-Class=Asthma 43 con f:(1) 859. Functional Concept=give 43 ==> Disease-Class=Asthma 43 conf:(1) 860. Functional Concept=abnormal 43 ==> Disease-Class=Asthma 43 conf:(1) 861. Physiologic Function=change in 43 ==> Disease-Class=Asthma 43 conf:(1) 862. Behavior Problem=alcohol abuse 43 ==> Disease-Class=Asthma 43 conf:(1) 863. Health Care Activity=hospitalization Spatial Concept=within 43 ==> Diseas e-Class=Asthma 43 conf:(1) 864. Temporal Concept=after Diagnostic Procedure=fev1 43 ==> Disease-Class=Ast hma 43 conf:(1) 865. Temporal Concept=prior to Quantitative Concept=exacerbation 43 ==> Diseas e-Class=Asthma 43 conf:(1) 866. Temporal Concept=period Disease or Syndrome=asthma 43 ==> Disease-Class=A sthma 43 conf:(1) 867. Temporal Concept=month NUMERAL=1.0 43 ==> Disease-Class=Asthma 43 conf :(1) 868. Intellectual Product=criteria Disease or Syndrome=asthma 43 ==> Disease-C lass=Asthma 43 conf:(1) 869. Pharmacologic Substance=agonist Qualitative Concept=beta 43 ==> Disease-C lass=Asthma 43 conf:(1) 870. Pharmacologic Substance=corticosteroids Laboratory Procedure=screening 43 ==> Disease-Class=Asthma 43 conf:(1) 871. SYMBOL=- Therapeutic or Preventive Procedure=ex 43 ==> Disease-Class=Asth ma 43 conf:(1) 872. SYMBOL=- Professional or Occupational Group=physician 43 ==> Disease-Clas s=Asthma 43 conf:(1) 873. SYMBOL=>= Therapeutic or Preventive Procedure=treatment 43 ==> Disease-Cl ass=Asthma 43 conf:(1) 874. SYMBOL=>= Disease or Syndrome=ics 43 ==> Disease-Class=Asthma 43 conf: (1) 875. NUMERAL=4.0 Research Activity=study 43 ==> Disease-Class=Asthma 43 con f:(1) 876. Functional Concept=non Behavior Problem=smoker 43 ==> Disease-Class=Asthm a 43 conf:(1) 877. Temporal Concept=years NUMERAL=60.0 Research Activity=study 43 ==> Diseas e-Class=Asthma 43 conf:(1) 878. Pharmacologic Substance=corticosteroids Body Space or Junction=oral Indiv idual Behavior=visit 43 ==> Disease-Class=Asthma 43 conf:(1) 879. SYMBOL=- Idea or Concept=acting Qualitative Concept=beta 43 ==> Disease-C lass=Asthma 43 conf:(1) 880. Spatial Concept=within Laboratory Procedure=screening Body Space or Junct ion=oral 43 ==> Disease-Class=Asthma 43 conf:(1) 881. Disease or Syndrome=asthma Professional or Occupational Group=physician D iagnostic Procedure=diagnosed 43 ==> Disease-Class=Asthma 43 conf:(1) 882. Pharmacologic Substance=fluticasone 42 ==> Disease-Class=Asthma 42 con f:(1) 883. NUMERAL=45.0 42 ==> Disease-Class=Asthma 42 conf:(1) 884. Idea or Concept=considered 42 ==> Disease-Class=Asthma 42 conf:(1) 885. Qualitative Concept=completion 42 ==> Disease-Class=Asthma 42 conf:(1) 886. Therapeutic or Preventive Procedure=treated 42 ==> Disease-Class=Asthma 4 2 conf:(1) 887. Disease or Syndrome=severe asthma 42 ==> Disease-Class=Asthma 42 conf: (1) 888. Virus=hiv 42 ==> Disease-Class=Asthma 42 conf:(1) 889. Phenomenon or Process=unstable 42 ==> Disease-Class=Asthma 42 conf:(1) 890. Mental Process=understand 42 ==> Disease-Class=Asthma 42 conf:(1) 891. Temporal Concept=history of Human=subject 42 ==> Disease-Class=Asthma 42 conf:(1) 892. SYMBOL=- Qualitative Concept=from 42 ==> Disease-Class=Asthma 42 conf: (1)

893. SYMBOL== UNIT=% 42 ==> Disease-Class=Asthma 42 conf:(1) 894. NUMERAL=60.0 Age Group=ages 42 ==> Disease-Class=Asthma 42 conf:(1) 895. Quantitative Concept=baseline Individual Behavior=visit 42 ==> Disease-Cl ass=Asthma 42 conf:(1) 896. Research Activity=study Finding=written 42 ==> Disease-Class=Asthma 42 conf:(1) 897. Disease or Syndrome=asthma Social Behavior=according 42 ==> Disease-Class =Asthma 42 conf:(1) 898. Temporal Concept=prior to SYMBOL=>= Individual Behavior=visit 42 ==> Dise ase-Class=Asthma 42 conf:(1) 899. Temporal Concept=prior to NUMERAL=1.0 Disease or Syndrome=asthma 42 ==> D isease-Class=Asthma 42 conf:(1) 900. Pharmacologic Substance=agonist SYMBOL=- Idea or Concept=acting 42 ==> Di sease-Class=Asthma 42 conf:(1) 901. Pharmacologic Substance=corticosteroids Spatial Concept=within Individual Behavior=visit 42 ==> Disease-Class=Asthma 42 conf:(1) 902. NUMERAL=1.0 Spatial Concept=within Body Space or Junction=oral 42 ==> Dis ease-Class=Asthma 42 conf:(1) 903. NUMERAL=12.0 Spatial Concept=within Laboratory Procedure=screening 42 ==> Disease-Class=Asthma 42 conf:(1) 904. NUMERAL=80.0 Idea or Concept=predicted Diagnostic Procedure=fev1 42 ==> D isease-Class=Asthma 42 conf:(1) 905. Spatial Concept=within Disease or Syndrome=asthma Laboratory Procedure=sc reening 42 ==> Disease-Class=Asthma 42 conf:(1) 906. NUMERAL=1.0 Spatial Concept=within Disease or Syndrome=asthma Individual Behavior=visit 42 ==> Disease-Class=Asthma 42 conf:(1) 907. NUMERAL=80.0 UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 4 2 ==> Disease-Class=Asthma 42 conf:(1) 908. Temporal Concept=course 41 ==> Disease-Class=Asthma 41 conf:(1) 909. Pharmacologic Substance=alcohol 41 ==> Disease-Class=Asthma 41 conf:(1 ) 910. NUMERAL=16.0 41 ==> Disease-Class=Asthma 41 conf:(1) 911. Quantitative Concept=six 41 ==> Disease-Class=Asthma 41 conf:(1) 912. Qualitative Concept=mild to moderate 41 ==> Disease-Class=Asthma 41 co nf:(1) 913. Qualitative Concept=beta2 41 ==> Disease-Class=Asthma 41 conf:(1) 914. Functional Concept=participating 41 ==> Disease-Class=Asthma 41 conf:( 1) 915. Spatial Concept=out 41 ==> Disease-Class=Asthma 41 conf:(1) 916. Body Substance=blood 41 ==> Disease-Class=Asthma 41 conf:(1) 917. Health Care Related Organization=hospital 41 ==> Disease-Class=Asthma 41 conf:(1) 918. Behavior Problem=smoked 41 ==> Disease-Class=Asthma 41 conf:(1) 919. Patient or Disabled Group=patients UNIT=% 41 ==> Disease-Class=Asthma 41 conf:(1) 920. Patient or Disabled Group=patient Professional or Occupational Group=inve stigator 41 ==> Disease-Class=Asthma 41 conf:(1) 921. Health Care Activity=documented SYMBOL=>= 41 ==> Disease-Class=Asthma 41 conf:(1) 922. Temporal Concept=years Finding=smoking history 41 ==> Disease-Class=Asthm a 41 conf:(1) 923. Temporal Concept=weeks Laboratory Procedure=screening 41 ==> Disease-Clas s=Asthma 41 conf:(1) 924. Pharmacologic Substance=medications Disease or Syndrome=asthma 41 ==> Dis ease-Class=Asthma 41 conf:(1) 925. Pharmacologic Substance=medication Spatial Concept=within 41 ==> DiseaseClass=Asthma 41 conf:(1) 926. Pharmacologic Substance=agonist Activity=inhaled 41 ==> Disease-Class=Ast hma 41 conf:(1) 927. Pharmacologic Substance=corticosteroids NUMERAL=1.0 41 ==> Disease-Class=

Asthma 41 conf:(1) 928. Pharmacologic Substance=corticosteroids Functional Concept=use of 41 ==> Disease-Class=Asthma 41 conf:(1) 929. SYMBOL=> NUMERAL=1.0 41 ==> Disease-Class=Asthma 41 conf:(1) 930. NUMERAL=30.0 Research Activity=study 41 ==> Disease-Class=Asthma 41 co nf:(1) 931. NUMERAL=4.0 Qualitative Concept=last 41 ==> Disease-Class=Asthma 41 co nf:(1) 932. NUMERAL=12.0 Individual Behavior=visit 41 ==> Disease-Class=Asthma 41 conf:(1) 933. NUMERAL=60.0 Idea or Concept=eligible 41 ==> Disease-Class=Asthma 41 c onf:(1) 934. Idea or Concept=predicted Laboratory Procedure=screening 41 ==> Disease-C lass=Asthma 41 conf:(1) 935. Research Activity=study Disease or Syndrome=disease 41 ==> Disease-Class= Asthma 41 conf:(1) 936. Research Activity=study Willing=agree 41 ==> Disease-Class=Asthma 41 c onf:(1) 937. Qualitative Concept=from Disease or Syndrome=asthma 41 ==> Disease-Class= Asthma 41 conf:(1) 938. Therapeutic or Preventive Procedure=treatment Functional Concept=requirin g 41 ==> Disease-Class=Asthma 41 conf:(1) 939. Functional Concept=non Behavior Problem=smokers 41 ==> Disease-Class=Asth ma 41 conf:(1) 940. Spatial Concept=within Diagnostic Procedure=fev1 41 ==> Disease-Class=Ast hma 41 conf:(1) 941. Activity=interfere Human=subject 41 ==> Disease-Class=Asthma 41 conf:( 1) 942. Temporal Concept=months NUMERAL=6.0 Spatial Concept=within 41 ==> Disease -Class=Asthma 41 conf:(1) 943. Temporal Concept=months Spatial Concept=within Disease or Syndrome=asthma 41 ==> Disease-Class=Asthma 41 conf:(1) 944. SYMBOL=- Research Activity=study Disease or Syndrome=asthma 41 ==> Diseas e-Class=Asthma 41 conf:(1) 945. SYMBOL=- Therapeutic or Preventive Procedure=treatment Activity=inhaled 4 1 ==> Disease-Class=Asthma 41 conf:(1) 946. NUMERAL=60.0 Idea or Concept=eligible Research Activity=study 41 ==> Dise ase-Class=Asthma 41 conf:(1) 947. NUMERAL=60.0 Idea or Concept=eligible Age Group=ages 41 ==> Disease-Class =Asthma 41 conf:(1) 948. NUMERAL=60.0 Research Activity=study Age Group=ages 41 ==> Disease-Class= Asthma 41 conf:(1) 949. Laboratory Procedure=screening Diagnostic Procedure=fev1 Individual Behav ior=visit 41 ==> Disease-Class=Asthma 41 conf:(1) 950. Laboratory Procedure=screening Individual Behavior=visit Human=subject 41 ==> Disease-Class=Asthma 41 conf:(1) 951. NUMERAL=60.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 41 ==> Disease-Class=Asthma 41 conf:(1) 952. Quantitative Concept=first 40 ==> Disease-Class=Asthma 40 conf:(1) 953. Qualitative Concept=mild 40 ==> Disease-Class=Asthma 40 conf:(1) 954. Population Group=guardian 40 ==> Disease-Class=Asthma 40 conf:(1) 955. Functional Concept=compliance 40 ==> Disease-Class=Asthma 40 conf:(1) 956. Disease or Syndrome=abnormality 40 ==> Disease-Class=Asthma 40 conf:(1 ) 957. Immunologic Factor=ige 40 ==> Disease-Class=Asthma 40 conf:(1) 958. Contraception=condom 40 ==> Disease-Class=Asthma 40 conf:(1) 959. Health Care Activity=diagnosis SYMBOL=- 40 ==> Disease-Class=Asthma 40 conf:(1) 960. Health Care Activity=documented Disease or Syndrome=asthma 40 ==> Disease -Class=Asthma 40 conf:(1)

961. Temporal Concept=duration Research Activity=study 40 ==> Disease-Class=As thma 40 conf:(1) 962. Temporal Concept=prior to Quantitative Concept=dose 40 ==> Disease-Class= Asthma 40 conf:(1) 963. Temporal Concept=prior to Idea or Concept=acting 40 ==> Disease-Class=Ast hma 40 conf:(1) 964. Temporal Concept=weeks Activity=inhaled 40 ==> Disease-Class=Asthma 40 conf:(1) 965. Temporal Concept=months SYMBOL=> 40 ==> Disease-Class=Asthma 40 conf:( 1) 966. Pharmacologic Substance=medication Individual Behavior=visit 40 ==> Disea se-Class=Asthma 40 conf:(1) 967. Pharmacologic Substance=drug Behavior Problem=alcohol abuse 40 ==> Diseas e-Class=Asthma 40 conf:(1) 968. Pharmacologic Substance=investigational drug Spatial Concept=within 40 == > Disease-Class=Asthma 40 conf:(1) 969. NO=no Disease or Syndrome=asthma 40 ==> Disease-Class=Asthma 40 conf:( 1) 970. SYMBOL=- Qualitative Concept=long 40 ==> Disease-Class=Asthma 40 conf: (1) 971. SYMBOL=> NUMERAL=10.0 40 ==> Disease-Class=Asthma 40 conf:(1) 972. SYMBOL=>= Qualitative Concept=stable 40 ==> Disease-Class=Asthma 40 co nf:(1) 973. NUMERAL=4.0 Activity=inhaled 40 ==> Disease-Class=Asthma 40 conf:(1) 974. NUMERAL=18.0 Age Group=age 40 ==> Disease-Class=Asthma 40 conf:(1) 975. NUMERAL=1.0 Functional Concept=use of 40 ==> Disease-Class=Asthma 40 c onf:(1) 976. NUMERAL=70.0 Idea or Concept=predicted 40 ==> Disease-Class=Asthma 40 conf:(1) 977. Quantitative Concept=baseline Idea or Concept=predicted 40 ==> Disease-Cl ass=Asthma 40 conf:(1) 978. Quantitative Concept=short Activity=inhaled 40 ==> Disease-Class=Asthma 4 0 conf:(1) 979. Idea or Concept=acting Qualitative Concept=long 40 ==> Disease-Class=Asth ma 40 conf:(1) 980. Idea or Concept=acting Functional Concept=use of 40 ==> Disease-Class=Ast hma 40 conf:(1) 981. Research Activity=study Capacity=ability 40 ==> Disease-Class=Asthma 40 conf:(1) 982. Qualitative Concept=from Laboratory Procedure=screening 40 ==> Disease-Cl ass=Asthma 40 conf:(1) 983. Functional Concept=use of Laboratory Procedure=screening 40 ==> Disease-C lass=Asthma 40 conf:(1) 984. Temporal Concept=years NUMERAL=60.0 Idea or Concept=eligible 40 ==> Disea se-Class=Asthma 40 conf:(1) 985. Temporal Concept=years NUMERAL=60.0 Age Group=ages 40 ==> Disease-Class=A sthma 40 conf:(1) 986. Temporal Concept=prior to SYMBOL=>= Disease or Syndrome=asthma 40 ==> Dis ease-Class=Asthma 40 conf:(1) 987. Temporal Concept=weeks Spatial Concept=within Laboratory Procedure=screen ing 40 ==> Disease-Class=Asthma 40 conf:(1) 988. Intellectual Product=pack years NUMERAL=10.0 Finding=smoking history 40 = => Disease-Class=Asthma 40 conf:(1) 989. SYMBOL=- Qualitative Concept=beta Activity=inhaled 40 ==> Disease-Class=A sthma 40 conf:(1) 990. NUMERAL=70.0 UNIT=% Idea or Concept=predicted 40 ==> Disease-Class=Asthma 40 conf:(1) 991. UNIT=% Spatial Concept=within Diagnostic Procedure=fev1 40 ==> Disease-Cl ass=Asthma 40 conf:(1) 992. Research Activity=study Spatial Concept=within Disease or Syndrome=asthma

40 ==> Disease-Class=Asthma 40 conf:(1) 993. Temporal Concept=years NUMERAL=60.0 Idea or Concept=eligible Research Act ivity=study 40 ==> Disease-Class=Asthma 40 conf:(1) 994. Temporal Concept=years NUMERAL=60.0 Idea or Concept=eligible Age Group=ag es 40 ==> Disease-Class=Asthma 40 conf:(1) 995. Temporal Concept=years NUMERAL=60.0 Research Activity=study Age Group=age s 40 ==> Disease-Class=Asthma 40 conf:(1) 996. Temporal Concept=years NUMERAL=60.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 40 ==> Disease-Class=Asthma 40 conf:(1) 997. Idea or Concept=continue 39 ==> Disease-Class=Asthma 39 conf:(1) 998. Qualitative Concept=associated with 39 ==> Disease-Class=Asthma 39 con f:(1) 999. Qualitative Concept=appropriate 39 ==> Disease-Class=Asthma 39 conf:(1 ) 1000. Pathologic Function=sterile 39 ==> Disease-Class=Asthma 39 conf:(1) 1001. Disease or Syndrome=asthmatics 39 ==> Disease-Class=Asthma 39 conf:(1) 1002. Temporal Concept=history of Pharmacologic Substance=drug 39 ==> Disease-C lass=Asthma 39 conf:(1) 1003. Temporal Concept=prior to NO=no 39 ==> Disease-Class=Asthma 39 conf:(1 ) 1004. Temporal Concept=prior to SYMBOL=> 39 ==> Disease-Class=Asthma 39 conf :(1) 1005. Temporal Concept=prior to NUMERAL=30.0 39 ==> Disease-Class=Asthma 39 conf:(1) 1006. Pharmacologic Substance=pef UNIT=% 39 ==> Disease-Class=Asthma 39 conf :(1) 1007. SYMBOL=- Qualitative Concept=related 39 ==> Disease-Class=Asthma 39 co nf:(1) 1008. SYMBOL=- Behavior Problem=smoking 39 ==> Disease-Class=Asthma 39 conf: (1) 1009. SYMBOL=>= NUMERAL=4.0 39 ==> Disease-Class=Asthma 39 conf:(1) 1010. NUMERAL=1.0 Human=subjects 39 ==> Disease-Class=Asthma 39 conf:(1) 1011. Quantitative Concept=or more Disease or Syndrome=asthma 39 ==> Disease-Cl ass=Asthma 39 conf:(1) 1012. Quantitative Concept=pack Finding=smoking history 39 ==> Disease-Class=As thma 39 conf:(1) 1013. Research Activity=entry Disease or Syndrome=asthma 39 ==> Disease-Class=A sthma 39 conf:(1) 1014. Qualitative Concept=stable Disease or Syndrome=asthma 39 ==> Disease-Clas s=Asthma 39 conf:(1) 1015. Functional Concept=use of Individual Behavior=visit 39 ==> Disease-Class= Asthma 39 conf:(1) 1016. Functional Concept=due to Disease or Syndrome=asthma 39 ==> Disease-Class =Asthma 39 conf:(1) 1017. Sign or Symptom=run Individual Behavior=visit 39 ==> Disease-Class=Asthma 39 conf:(1) 1018. Patient or Disabled Group=patients NUMERAL=1.0 Individual Behavior=visit 39 ==> Disease-Class=Asthma 39 conf:(1) 1019. SYMBOL=- Research Activity=study Individual Behavior=visit 39 ==> Disease -Class=Asthma 39 conf:(1) 1020. NUMERAL=1.0 Body Space or Junction=oral Individual Behavior=visit 39 ==> Disease-Class=Asthma 39 conf:(1) 1021. Quantitative Concept=baseline UNIT=% Idea or Concept=predicted 39 ==> Dis ease-Class=Asthma 39 conf:(1) 1022. Quantitative Concept=short Idea or Concept=acting Activity=inhaled 39 ==> Disease-Class=Asthma 39 conf:(1) 1023. Research Activity=study Spatial Concept=within Human=subject 39 ==> Disea se-Class=Asthma 39 conf:(1) 1024. Research Activity=study Professional or Occupational Group=investigator I ndividual Behavior=participation 39 ==> Disease-Class=Asthma 39 conf:(1)

1025. Functional Concept=use of Spatial Concept=within Body Space or Junction=o ral 39 ==> Disease-Class=Asthma 39 conf:(1) 1026. Temporal Concept=per day 38 ==> Disease-Class=Asthma 38 conf:(1) 1027. Pharmacologic Substance=drug abuse 38 ==> Disease-Class=Asthma 38 conf :(1) 1028. Organism Attribute=male 38 ==> Disease-Class=Asthma 38 conf:(1) 1029. Functional Concept=results 38 ==> Disease-Class=Asthma 38 conf:(1) 1030. Functional Concept=affect 38 ==> Disease-Class=Asthma 38 conf:(1) 1031. Functional Concept=measurements 38 ==> Disease-Class=Asthma 38 conf:(1 ) 1032. Organism Function=pregnancy test 38 ==> Disease-Class=Asthma 38 conf:( 1) 1033. Organ or Tissue Function=lung function 38 ==> Disease-Class=Asthma 38 conf:(1) 1034. Health Care Activity=documented Laboratory Procedure=screening 38 ==> Dis ease-Class=Asthma 38 conf:(1) 1035. Temporal Concept=preceding Individual Behavior=visit 38 ==> Disease-Class =Asthma 38 conf:(1) 1036. Pharmacologic Substance=bronchodilator SYMBOL=- 38 ==> Disease-Class=Asth ma 38 conf:(1) 1037. NO=not Functional Concept=using 38 ==> Disease-Class=Asthma 38 conf:(1 ) 1038. SYMBOL=- Functional Concept=using 38 ==> Disease-Class=Asthma 38 conf: (1) 1039. SYMBOL=> Research Activity=study 38 ==> Disease-Class=Asthma 38 conf:( 1) 1040. SYMBOL=< Individual Behavior=visit 38 ==> Disease-Class=Asthma 38 conf :(1) 1041. SYMBOL=>= Quantitative Concept=dose 38 ==> Disease-Class=Asthma 38 con f:(1) 1042. SYMBOL=>= Functional Concept=use of 38 ==> Disease-Class=Asthma 38 con f:(1) 1043. SYMBOL== Diagnostic Procedure=fev1 38 ==> Disease-Class=Asthma 38 conf :(1) 1044. NUMERAL=5.0 Research Activity=study 38 ==> Disease-Class=Asthma 38 con f:(1) 1045. NUMERAL=6.0 Individual Behavior=visit 38 ==> Disease-Class=Asthma 38 c onf:(1) 1046. NUMERAL=60.0 Idea or Concept=predicted 38 ==> Disease-Class=Asthma 38 conf:(1) 1047. Quantitative Concept=ml UNIT=% 38 ==> Disease-Class=Asthma 38 conf:(1) 1048. UNIT=% Organism Function=inhalation 38 ==> Disease-Class=Asthma 38 con f:(1) 1049. UNIT=% Human=subjects 38 ==> Disease-Class=Asthma 38 conf:(1) 1050. Organism Attribute=female Age Group=aged 38 ==> Disease-Class=Asthma 38 conf:(1) 1051. Qualitative Concept=pre Diagnostic Procedure=fev1 38 ==> Disease-Class=As thma 38 conf:(1) 1052. Therapeutic or Preventive Procedure=therapy Disease or Syndrome=asthma 38 ==> Disease-Class=Asthma 38 conf:(1) 1053. Disease or Syndrome=asthma Age Group=age 38 ==> Disease-Class=Asthma 38 conf:(1) 1054. Diagnostic Procedure=fev1 Organic Chemical=methacholine 38 ==> Disease-Cl ass=Asthma 38 conf:(1) 1055. Temporal Concept=after UNIT=% Diagnostic Procedure=fev1 38 ==> Disease-Cl ass=Asthma 38 conf:(1) 1056. Temporal Concept=prior to SYMBOL=- Disease or Syndrome=asthma 38 ==> Dise ase-Class=Asthma 38 conf:(1) 1057. Temporal Concept=prior to NUMERAL=12.0 Spatial Concept=within 38 ==> Dise ase-Class=Asthma 38 conf:(1)

1058. Temporal Concept=prior to NUMERAL=12.0 Laboratory Procedure=screening 38 ==> Disease-Class=Asthma 38 conf:(1) 1059. SYMBOL=>= NUMERAL=1.0 Individual Behavior=visit 38 ==> Disease-Class=Asth ma 38 conf:(1) 1060. NUMERAL=12.0 Laboratory Procedure=screening Individual Behavior=visit 38 ==> Disease-Class=Asthma 38 conf:(1) 1061. NUMERAL=60.0 UNIT=% Idea or Concept=predicted 38 ==> Disease-Class=Asthma 38 conf:(1) 1062. UNIT=% Idea or Concept=predicted Laboratory Procedure=screening 38 ==> Di sease-Class=Asthma 38 conf:(1) 1063. SYMBOL=- Spatial Concept=within Laboratory Procedure=screening Individual Behavior=visit 38 ==> Disease-Class=Asthma 38 conf:(1) 1064. Intellectual Product=upon 37 ==> Disease-Class=Asthma 37 conf:(1) 1065. Quantitative Concept=dosing 37 ==> Disease-Class=Asthma 37 conf:(1) 1066. Qualitative Concept=healthy 37 ==> Disease-Class=Asthma 37 conf:(1) 1067. Therapeutic or Preventive Procedure=immunotherapy 37 ==> Disease-Class=As thma 37 conf:(1) 1068. Activity=put 37 ==> Disease-Class=Asthma 37 conf:(1) 1069. Manufactured Object=cigarettes 37 ==> Disease-Class=Asthma 37 conf:(1) 1070. Patient or Disabled Group=patients Activity=inhaled 37 ==> Disease-Class= Asthma 37 conf:(1) 1071. Temporal Concept=prior to Research Activity=randomization 37 ==> DiseaseClass=Asthma 37 conf:(1) 1072. Temporal Concept=weeks NUMERAL=2.0 37 ==> Disease-Class=Asthma 37 conf :(1) 1073. NO=not Laboratory Procedure=screening 37 ==> Disease-Class=Asthma 37 c onf:(1) 1074. SYMBOL=- Spatial Concept=between 37 ==> Disease-Class=Asthma 37 conf:( 1) 1075. SYMBOL=> NUMERAL=6.0 37 ==> Disease-Class=Asthma 37 conf:(1) 1076. SYMBOL=< Laboratory or Test Result=pc20 37 ==> Disease-Class=Asthma 37 conf:(1) 1077. NUMERAL=10.0 Behavior Problem=smoking 37 ==> Disease-Class=Asthma 37 c onf:(1) 1078. NUMERAL=1.0 Activity=inhaled 37 ==> Disease-Class=Asthma 37 conf:(1) 1079. Quantitative Concept=one Disease or Syndrome=asthma 37 ==> Disease-Class= Asthma 37 conf:(1) 1080. UNIT=% Activity=inhaled 37 ==> Disease-Class=Asthma 37 conf:(1) 1081. UNIT=time Research Activity=study 37 ==> Disease-Class=Asthma 37 conf: (1) 1082. Qualitative Concept=last Individual Behavior=visit 37 ==> Disease-Class=A sthma 37 conf:(1) 1083. Therapeutic or Preventive Procedure=intubation Disease or Syndrome=asthma 37 ==> Disease-Class=Asthma 37 conf:(1) 1084. Functional Concept=including Disease or Syndrome=asthma 37 ==> Disease-Cl ass=Asthma 37 conf:(1) 1085. Functional Concept=use Individual Behavior=visit 37 ==> Disease-Class=Ast hma 37 conf:(1) 1086. Spatial Concept=within Finding=smoking history 37 ==> Disease-Class=Asthm a 37 conf:(1) 1087. Temporal Concept=weeks Spatial Concept=within Body Space or Junction=oral 37 ==> Disease-Class=Asthma 37 conf:(1) 1088. SYMBOL=- NUMERAL=10.0 Finding=smoking history 37 ==> Disease-Class=Asthma 37 conf:(1) 1089. SYMBOL=- Disease or Syndrome=asthma Laboratory Procedure=screening 37 ==> Disease-Class=Asthma 37 conf:(1) 1090. SYMBOL=- Disease or Syndrome=asthma Diagnostic Procedure=diagnosed 37 ==> Disease-Class=Asthma 37 conf:(1) 1091. Idea or Concept=predicted Diagnostic Procedure=fev1 Individual Behavior=v isit 37 ==> Disease-Class=Asthma 37 conf:(1)

1092. UNIT=% Laboratory Procedure=screening Diagnostic Procedure=fev1 Individua l Behavior=visit 37 ==> Disease-Class=Asthma 37 conf:(1) 1093. Temporal Concept=post 36 ==> Disease-Class=Asthma 36 conf:(1) 1094. Intellectual Product=levels 36 ==> Disease-Class=Asthma 36 conf:(1) 1095. Quantitative Concept=per 36 ==> Disease-Class=Asthma 36 conf:(1) 1096. Quantitative Concept=product 36 ==> Disease-Class=Asthma 36 conf:(1) 1097. Population Group=participants 36 ==> Disease-Class=Asthma 36 conf:(1) 1098. Body Location or Region=chest 36 ==> Disease-Class=Asthma 36 conf:(1) 1099. Organic Chemical=saba 36 ==> Disease-Class=Asthma 36 conf:(1) 1100. Patient or Disabled Group=patients Therapeutic or Preventive Procedure=tr eatment 36 ==> Disease-Class=Asthma 36 conf:(1) 1101. Intellectual Product=criteria SYMBOL=- 36 ==> Disease-Class=Asthma 36 conf:(1) 1102. Intellectual Product=guidelines Research Activity=gina 36 ==> Disease-Cla ss=Asthma 36 conf:(1) 1103. SYMBOL=- Spatial Concept=up 36 ==> Disease-Class=Asthma 36 conf:(1) 1104. SYMBOL=- Classification=b 36 ==> Disease-Class=Asthma 36 conf:(1) 1105. SYMBOL=- Age Group=child 36 ==> Disease-Class=Asthma 36 conf:(1) 1106. SYMBOL=< Disease or Syndrome=asthma 36 ==> Disease-Class=Asthma 36 con f:(1) 1107. SYMBOL=>= Idea or Concept=acting 36 ==> Disease-Class=Asthma 36 conf:( 1) 1108. NUMERAL=4.0 Body Space or Junction=oral 36 ==> Disease-Class=Asthma 36 conf:(1) 1109. NUMERAL=55.0 Age Group=ages 36 ==> Disease-Class=Asthma 36 conf:(1) 1110. Quantitative Concept=exacerbation Individual Behavior=visit 36 ==> Diseas e-Class=Asthma 36 conf:(1) 1111. Quantitative Concept=dose Individual Behavior=visit 36 ==> Disease-Class= Asthma 36 conf:(1) 1112. Quantitative Concept=value Diagnostic Procedure=fev1 36 ==> Disease-Class =Asthma 36 conf:(1) 1113. UNIT=% Qualitative Concept=normal 36 ==> Disease-Class=Asthma 36 conf: (1) 1114. UNIT=% Organic Chemical=methacholine 36 ==> Disease-Class=Asthma 36 co nf:(1) 1115. Research Activity=study Compliance=comply 36 ==> Disease-Class=Asthma 36 conf:(1) 1116. Qualitative Concept=mild to moderate Disease or Syndrome=asthma 36 ==> Di sease-Class=Asthma 36 conf:(1) 1117. Functional Concept=give Regulation or Law=informed consent 36 ==> Disease -Class=Asthma 36 conf:(1) 1118. Functional Concept=systemic Body Space or Junction=oral 36 ==> Disease-Cl ass=Asthma 36 conf:(1) 1119. Activity=inhaled Human=subjects 36 ==> Disease-Class=Asthma 36 conf:(1 ) 1120. Patient or Disabled Group=patient Research Activity=study Professional or Occupational Group=investigator 36 ==> Disease-Class=Asthma 36 conf:(1) 1121. Temporal Concept=prior to SYMBOL=>= NUMERAL=1.0 36 ==> Disease-Class=Asth ma 36 conf:(1) 1122. Pharmacologic Substance=corticosteroids Disease or Syndrome=asthma Body S pace or Junction=oral 36 ==> Disease-Class=Asthma 36 conf:(1) 1123. NO=not SYMBOL=- Research Activity=study 36 ==> Disease-Class=Asthma 36 conf:(1) 1124. SYMBOL=- NUMERAL=1.0 Spatial Concept=within 36 ==> Disease-Class=Asthma 3 6 conf:(1) 1125. SYMBOL=- Quantitative Concept=pack Finding=smoking history 36 ==> Disease -Class=Asthma 36 conf:(1) 1126. SYMBOL=- Idea or Concept=acting Disease or Syndrome=asthma 36 ==> Disease -Class=Asthma 36 conf:(1) 1127. SYMBOL=- Disease or Syndrome=asthma Individual Behavior=visit 36 ==> Dise

ase-Class=Asthma 36 conf:(1) 1128. NUMERAL=1.0 Individual Behavior=visit Human=subject 36 ==> Disease-Class= Asthma 36 conf:(1) 1129. Idea or Concept=acting Qualitative Concept=beta Activity=inhaled 36 ==> D isease-Class=Asthma 36 conf:(1) 1130. Research Activity=study Spatial Concept=within Individual Behavior=visit 36 ==> Disease-Class=Asthma 36 conf:(1) 1131. Research Activity=study Professional or Occupational Group=investigator H uman=subject 36 ==> Disease-Class=Asthma 36 conf:(1) 1132. Spatial Concept=within Activity=inhaled Body Space or Junction=oral 36 == > Disease-Class=Asthma 36 conf:(1) 1133. UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 Individual Beh avior=visit 36 ==> Disease-Class=Asthma 36 conf:(1) 1134. Health Care Activity=feeding 35 ==> Disease-Class=Asthma 35 conf:(1) 1135. Intellectual Product=diary 35 ==> Disease-Class=Asthma 35 conf:(1) 1136. NUMERAL=17.0 35 ==> Disease-Class=Asthma 35 conf:(1) 1137. Quantitative Concept=exacerbations 35 ==> Disease-Class=Asthma 35 conf :(1) 1138. Quantitative Concept=values 35 ==> Disease-Class=Asthma 35 conf:(1) 1139. Population Group=american 35 ==> Disease-Class=Asthma 35 conf:(1) 1140. Neoplastic Process=cancer 35 ==> Disease-Class=Asthma 35 conf:(1) 1141. MARK=* 35 ==> Disease-Class=Asthma 35 conf:(1) 1142. Professional or Occupational Group=medically 35 ==> Disease-Class=Asthma 35 conf:(1) 1143. Organization=society 35 ==> Disease-Class=Asthma 35 conf:(1) 1144. Health Care Activity=diagnosis Temporal Concept=months 35 ==> Disease-Cla ss=Asthma 35 conf:(1) 1145. Health Care Activity=hospitalization Individual Behavior=visit 35 ==> Dis ease-Class=Asthma 35 conf:(1) 1146. Health Care Activity=enrollment Temporal Concept=prior to 35 ==> DiseaseClass=Asthma 35 conf:(1) 1147. Health Care Activity=apply NO=exclusion criteria 35 ==> Disease-Class=Ast hma 35 conf:(1) 1148. Temporal Concept=years NUMERAL=11.0 35 ==> Disease-Class=Asthma 35 con f:(1) 1149. Temporal Concept=prior to Qualitative Concept=stable 35 ==> Disease-Class =Asthma 35 conf:(1) 1150. Temporal Concept=months Individual Behavior=visit 35 ==> Disease-Class=As thma 35 conf:(1) 1151. Pharmacologic Substance=medication Laboratory Procedure=screening 35 ==> Disease-Class=Asthma 35 conf:(1) 1152. Pharmacologic Substance=medication Human=subject 35 ==> Disease-Class=Ast hma 35 conf:(1) 1153. Pharmacologic Substance=bronchodilator Idea or Concept=predicted 35 ==> D isease-Class=Asthma 35 conf:(1) 1154. NO=no Research Activity=study 35 ==> Disease-Class=Asthma 35 conf:(1) 1155. NO=not SYMBOL=>= 35 ==> Disease-Class=Asthma 35 conf:(1) 1156. NO=not Activity=inhaled 35 ==> Disease-Class=Asthma 35 conf:(1) 1157. SYMBOL=- MARK=] 35 ==> Disease-Class=Asthma 35 conf:(1) 1158. SYMBOL=>= Age Group=age 35 ==> Disease-Class=Asthma 35 conf:(1) 1159. SYMBOL=>= Sign or Symptom=symptoms 35 ==> Disease-Class=Asthma 35 conf :(1) 1160. NUMERAL=2.0 Idea or Concept=acting 35 ==> Disease-Class=Asthma 35 conf :(1) 1161. NUMERAL=3.0 Research Activity=study 35 ==> Disease-Class=Asthma 35 con f:(1) 1162. NUMERAL=3.0 Body Space or Junction=oral 35 ==> Disease-Class=Asthma 35 conf:(1) 1163. NUMERAL=55.0 Idea or Concept=eligible 35 ==> Disease-Class=Asthma 35 c onf:(1)

1164. NUMERAL=55.0 Research Activity=study 35 ==> Disease-Class=Asthma 35 co nf:(1) 1165. Quantitative Concept=dose Activity=inhaled 35 ==> Disease-Class=Asthma 35 conf:(1) 1166. Research Activity=study Qualitative Concept=has 35 ==> Disease-Class=Asth ma 35 conf:(1) 1167. Research Activity=study Functional Concept=including 35 ==> Disease-Class =Asthma 35 conf:(1) 1168. Qualitative Concept=normal Diagnostic Procedure=fev1 35 ==> Disease-Class =Asthma 35 conf:(1) 1169. Functional Concept=start Spatial Concept=within 35 ==> Disease-Class=Asth ma 35 conf:(1) 1170. Temporal Concept=years NUMERAL=55.0 Idea or Concept=eligible 35 ==> Disea se-Class=Asthma 35 conf:(1) 1171. Temporal Concept=years NUMERAL=55.0 Research Activity=study 35 ==> Diseas e-Class=Asthma 35 conf:(1) 1172. Temporal Concept=years NUMERAL=55.0 Age Group=ages 35 ==> Disease-Class=A sthma 35 conf:(1) 1173. Temporal Concept=prior to Research Activity=study Disease or Syndrome=ast hma 35 ==> Disease-Class=Asthma 35 conf:(1) 1174. Temporal Concept=months NUMERAL=3.0 Disease or Syndrome=asthma 35 ==> Dis ease-Class=Asthma 35 conf:(1) 1175. Pharmacologic Substance=agonist Idea or Concept=acting Activity=inhaled 3 5 ==> Disease-Class=Asthma 35 conf:(1) 1176. SYMBOL=- Idea or Concept=acting Qualitative Concept=long 35 ==> Disease-C lass=Asthma 35 conf:(1) 1177. SYMBOL=>= Laboratory Procedure=screening Individual Behavior=visit 35 ==> Disease-Class=Asthma 35 conf:(1) 1178. NUMERAL=70.0 Idea or Concept=predicted Diagnostic Procedure=fev1 35 ==> D isease-Class=Asthma 35 conf:(1) 1179. NUMERAL=55.0 Idea or Concept=eligible Research Activity=study 35 ==> Dise ase-Class=Asthma 35 conf:(1) 1180. NUMERAL=55.0 Idea or Concept=eligible Age Group=ages 35 ==> Disease-Class =Asthma 35 conf:(1) 1181. NUMERAL=55.0 Research Activity=study Age Group=ages 35 ==> Disease-Class= Asthma 35 conf:(1) 1182. NUMERAL=60.0 Idea or Concept=predicted Diagnostic Procedure=fev1 35 ==> D isease-Class=Asthma 35 conf:(1) 1183. Quantitative Concept=ml Laboratory or Test Result=pc20 Organic Chemical=m ethacholine 35 ==> Disease-Class=Asthma 35 conf:(1) 1184. Quantitative Concept=baseline Idea or Concept=predicted Diagnostic Proced ure=fev1 35 ==> Disease-Class=Asthma 35 conf:(1) 1185. UNIT=% Qualitative Concept=pre Diagnostic Procedure=fev1 35 ==> Disease-C lass=Asthma 35 conf:(1) 1186. Research Activity=study Functional Concept=start Spatial Concept=within 3 5 ==> Disease-Class=Asthma 35 conf:(1) 1187. Temporal Concept=years NUMERAL=55.0 Idea or Concept=eligible Research Act ivity=study 35 ==> Disease-Class=Asthma 35 conf:(1) 1188. Temporal Concept=years NUMERAL=55.0 Idea or Concept=eligible Age Group=ag es 35 ==> Disease-Class=Asthma 35 conf:(1) 1189. Temporal Concept=years NUMERAL=55.0 Research Activity=study Age Group=age s 35 ==> Disease-Class=Asthma 35 conf:(1) 1190. NUMERAL=1.0 Spatial Concept=within Laboratory Procedure=screening Individ ual Behavior=visit 35 ==> Disease-Class=Asthma 35 conf:(1) 1191. NUMERAL=1.0 Spatial Concept=within Body Space or Junction=oral Individual Behavior=visit 35 ==> Disease-Class=Asthma 35 conf:(1) 1192. NUMERAL=70.0 UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 3 5 ==> Disease-Class=Asthma 35 conf:(1) 1193. NUMERAL=55.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 35 ==> Disease-Class=Asthma 35 conf:(1)

1194. NUMERAL=60.0 UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 3 5 ==> Disease-Class=Asthma 35 conf:(1) 1195. Quantitative Concept=baseline UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 35 ==> Disease-Class=Asthma 35 conf:(1) 1196. Temporal Concept=years NUMERAL=55.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 35 ==> Disease-Class=Asthma 35 conf:(1) 1197. Temporal Concept=recent 34 ==> Disease-Class=Asthma 34 conf:(1) 1198. Pharmacologic Substance=spermicide 34 ==> Disease-Class=Asthma 34 conf :(1) 1199. Quantitative Concept=four 34 ==> Disease-Class=Asthma 34 conf:(1) 1200. Qualitative Concept=form 34 ==> Disease-Class=Asthma 34 conf:(1) 1201. Spatial Concept=upper 34 ==> Disease-Class=Asthma 34 conf:(1) 1202. Disease or Syndrome=bronchial asthma 34 ==> Disease-Class=Asthma 34 co nf:(1) 1203. Body Location or Region=low 34 ==> Disease-Class=Asthma 34 conf:(1) 1204. Diagnostic Procedure=bronchoscopy 34 ==> Disease-Class=Asthma 34 conf: (1) 1205. Activity=taken 34 ==> Disease-Class=Asthma 34 conf:(1) 1206. Hazardous or Poisonous Substance=cigarette smoking 34 ==> Disease-Class=A sthma 34 conf:(1) 1207. Temporal Concept=years Age Group=old 34 ==> Disease-Class=Asthma 34 co nf:(1) 1208. Temporal Concept=years Human=subjects 34 ==> Disease-Class=Asthma 34 c onf:(1) 1209. Temporal Concept=history of Research Activity=study 34 ==> Disease-Class= Asthma 34 conf:(1) 1210. Temporal Concept=after SYMBOL=- 34 ==> Disease-Class=Asthma 34 conf:(1 ) 1211. Temporal Concept=prior to Quantitative Concept=one 34 ==> Disease-Class=A sthma 34 conf:(1) 1212. Temporal Concept=during SYMBOL=- 34 ==> Disease-Class=Asthma 34 conf:( 1) 1213. Temporal Concept=weeks NUMERAL=1.0 34 ==> Disease-Class=Asthma 34 conf :(1) 1214. Temporal Concept=year Disease or Syndrome=asthma 34 ==> Disease-Class=Ast hma 34 conf:(1) 1215. Pharmacologic Substance=agonists Activity=inhaled 34 ==> Disease-Class=As thma 34 conf:(1) 1216. Pharmacologic Substance=albuterol Diagnostic Procedure=fev1 34 ==> Diseas e-Class=Asthma 34 conf:(1) 1217. Pharmacologic Substance=corticosteroids SYMBOL=- 34 ==> Disease-Class=Ast hma 34 conf:(1) 1218. SYMBOL=- Disease or Syndrome=ics 34 ==> Disease-Class=Asthma 34 conf:( 1) 1219. SYMBOL=>= Human=subject 34 ==> Disease-Class=Asthma 34 conf:(1) 1220. Quantitative Concept=ml Diagnostic Procedure=fev1 34 ==> Disease-Class=As thma 34 conf:(1) 1221. Quantitative Concept=short Disease or Syndrome=asthma 34 ==> Disease-Clas s=Asthma 34 conf:(1) 1222. Organism Attribute=female Human=subject 34 ==> Disease-Class=Asthma 34 conf:(1) 1223. Idea or Concept=acting Therapeutic or Preventive Procedure=treatment 34 = => Disease-Class=Asthma 34 conf:(1) 1224. Idea or Concept=opinion Individual Behavior=participation 34 ==> DiseaseClass=Asthma 34 conf:(1) 1225. Population Group=guardian Family Group=parent 34 ==> Disease-Class=Asthma 34 conf:(1) 1226. Therapeutic or Preventive Procedure=ex Behavior Problem=smokers 34 ==> Di sease-Class=Asthma 34 conf:(1) 1227. Functional Concept=required Disease or Syndrome=asthma 34 ==> Disease-Cla

ss=Asthma 34 conf:(1) 1228. Functional Concept=used Spatial Concept=within 34 ==> Disease-Class=Asthm a 34 conf:(1) 1229. Functional Concept=systemic Individual Behavior=visit 34 ==> Disease-Clas s=Asthma 34 conf:(1) 1230. Disease or Syndrome=asthma Sign or Symptom=run 34 ==> Disease-Class=Asthm a 34 conf:(1) 1231. Regulation or Law=informed consent Willing=willing 34 ==> Disease-Class=A sthma 34 conf:(1) 1232. Patient or Disabled Group=patients Temporal Concept=prior to Individual B ehavior=visit 34 ==> Disease-Class=Asthma 34 conf:(1) 1233. Health Care Activity=diagnosis Disease or Syndrome=asthma Professional or Occupational Group=physician 34 ==> Disease-Class=Asthma 34 conf:(1) 1234. Temporal Concept=prior to SYMBOL=>= Activity=inhaled 34 ==> Disease-Class =Asthma 34 conf:(1) 1235. Pharmacologic Substance=corticosteroids NUMERAL=1.0 Spatial Concept=withi n 34 ==> Disease-Class=Asthma 34 conf:(1) 1236. Pharmacologic Substance=bronchodilator UNIT=% Idea or Concept=predicted 3 4 ==> Disease-Class=Asthma 34 conf:(1) 1237. SYMBOL=- UNIT=% Individual Behavior=visit 34 ==> Disease-Class=Asthma 34 conf:(1) 1238. SYMBOL=- Sign or Symptom=run Individual Behavior=visit 34 ==> Disease-Cla ss=Asthma 34 conf:(1) 1239. SYMBOL== UNIT=% Diagnostic Procedure=fev1 34 ==> Disease-Class=Asthma 34 conf:(1) 1240. Quantitative Concept=value UNIT=% Diagnostic Procedure=fev1 34 ==> Diseas e-Class=Asthma 34 conf:(1) 1241. Temporal Concept=months SYMBOL=>= NUMERAL=6.0 Disease or Syndrome=asthma 34 ==> Disease-Class=Asthma 34 conf:(1) 1242. Pharmacologic Substance=corticosteroids Spatial Concept=within Body Space or Junction=oral Individual Behavior=visit 34 ==> Disease-Class=Asthma 34 co nf:(1) 1243. Temporal Concept=concurrent 33 ==> Disease-Class=Asthma 33 conf:(1) 1244. Clinical Attribute=bmi 33 ==> Disease-Class=Asthma 33 conf:(1) 1245. NUMERAL=500.0 33 ==> Disease-Class=Asthma 33 conf:(1) 1246. Quantitative Concept=score 33 ==> Disease-Class=Asthma 33 conf:(1) 1247. UNIT=times 33 ==> Disease-Class=Asthma 33 conf:(1) 1248. Idea or Concept=requirements 33 ==> Disease-Class=Asthma 33 conf:(1) 1249. Qualitative Concept=suspected 33 ==> Disease-Class=Asthma 33 conf:(1) 1250. Pathologic Function=obstruction 33 ==> Disease-Class=Asthma 33 conf:(1 ) 1251. Disease or Syndrome=acute asthma 33 ==> Disease-Class=Asthma 33 conf:( 1) 1252. Disease or Syndrome=thoracic 33 ==> Disease-Class=Asthma 33 conf:(1) 1253. Neoplastic Process=malignancy 33 ==> Disease-Class=Asthma 33 conf:(1) 1254. Finding=good health 33 ==> Disease-Class=Asthma 33 conf:(1) 1255. Finding=lives 33 ==> Disease-Class=Asthma 33 conf:(1) 1256. Activity=take 33 ==> Disease-Class=Asthma 33 conf:(1) 1257. Family Group=parents 33 ==> Disease-Class=Asthma 33 conf:(1) 1258. Health Care Activity=feeding SYMBOL=- 33 ==> Disease-Class=Asthma 33 c onf:(1) 1259. Health Care Activity=apply SYMBOL=- 33 ==> Disease-Class=Asthma 33 con f:(1) 1260. Temporal Concept=history of Allergy=allergy 33 ==> Disease-Class=Asthma 3 3 conf:(1) 1261. Temporal Concept=prior to NO=not 33 ==> Disease-Class=Asthma 33 conf:( 1) 1262. Temporal Concept=during Laboratory Procedure=screening 33 ==> Disease-Cla ss=Asthma 33 conf:(1) 1263. Temporal Concept=months Laboratory Procedure=screening 33 ==> Disease-Cla

ss=Asthma 33 conf:(1) 1264. Temporal Concept=year SYMBOL=> 33 ==> Disease-Class=Asthma 33 conf:(1) 1265. Temporal Concept=year SYMBOL=>= 33 ==> Disease-Class=Asthma 33 conf:(1 ) 1266. Temporal Concept=before SYMBOL=- 33 ==> Disease-Class=Asthma 33 conf:( 1) 1267. Intellectual Product=method Research Activity=study 33 ==> Disease-Class= Asthma 33 conf:(1) 1268. Pharmacologic Substance=salbutamol UNIT=% 33 ==> Disease-Class=Asthma 33 conf:(1) 1269. SYMBOL=- Sign or Symptom=symptoms 33 ==> Disease-Class=Asthma 33 conf: (1) 1270. SYMBOL=> Quantitative Concept=baseline 33 ==> Disease-Class=Asthma 33 conf:(1) 1271. SYMBOL=>= Organism Attribute=female 33 ==> Disease-Class=Asthma 33 con f:(1) 1272. NUMERAL=65.0 Age Group=age 33 ==> Disease-Class=Asthma 33 conf:(1) 1273. NUMERAL=2.0 Activity=inhaled 33 ==> Disease-Class=Asthma 33 conf:(1) 1274. NUMERAL=4.0 Therapeutic or Preventive Procedure=treatment 33 ==> DiseaseClass=Asthma 33 conf:(1) 1275. NUMERAL=90.0 UNIT=% 33 ==> Disease-Class=Asthma 33 conf:(1) 1276. NUMERAL=50.0 Research Activity=study 33 ==> Disease-Class=Asthma 33 co nf:(1) 1277. NUMERAL=50.0 Age Group=ages 33 ==> Disease-Class=Asthma 33 conf:(1) 1278. Quantitative Concept=short Qualitative Concept=beta 33 ==> Disease-Class= Asthma 33 conf:(1) 1279. Laboratory or Test Result=pc20 UNIT=% 33 ==> Disease-Class=Asthma 33 c onf:(1) 1280. Idea or Concept=continue Research Activity=study 33 ==> Disease-Class=Ast hma 33 conf:(1) 1281. Research Activity=study Functional Concept=using 33 ==> Disease-Class=Ast hma 33 conf:(1) 1282. Research Activity=study Human-caused Phenomenon or Process=safety 33 ==> Disease-Class=Asthma 33 conf:(1) 1283. Functional Concept=requiring Spatial Concept=within 33 ==> Disease-Class= Asthma 33 conf:(1) 1284. Disease or Syndrome=asthma Individual Behavior=visits 33 ==> Disease-Clas s=Asthma 33 conf:(1) 1285. Disease or Syndrome=ics Activity=inhaled 33 ==> Disease-Class=Asthma 33 conf:(1) 1286. Temporal Concept=years NUMERAL=10.0 Finding=smoking history 33 ==> Diseas e-Class=Asthma 33 conf:(1) 1287. Temporal Concept=days NUMERAL=30.0 Spatial Concept=within 33 ==> DiseaseClass=Asthma 33 conf:(1) 1288. Temporal Concept=prior to Spatial Concept=within Body Space or Junction=o ral 33 ==> Disease-Class=Asthma 33 conf:(1) 1289. Temporal Concept=weeks NUMERAL=1.0 Individual Behavior=visit 33 ==> Disea se-Class=Asthma 33 conf:(1) 1290. Temporal Concept=weeks Spatial Concept=within Disease or Syndrome=asthma 33 ==> Disease-Class=Asthma 33 conf:(1) 1291. Pharmacologic Substance=bronchodilator Idea or Concept=predicted Diagnost ic Procedure=fev1 33 ==> Disease-Class=Asthma 33 conf:(1) 1292. SYMBOL=- UNIT=% Laboratory Procedure=screening 33 ==> Disease-Class=Asthm a 33 conf:(1) 1293. SYMBOL=- Idea or Concept=acting Individual Behavior=visit 33 ==> DiseaseClass=Asthma 33 conf:(1) 1294. SYMBOL=- Disease or Syndrome=asthma Activity=inhaled 33 ==> Disease-Class =Asthma 33 conf:(1) 1295. NUMERAL=1.0 Therapeutic or Preventive Procedure=treatment Individual Beha vior=visit 33 ==> Disease-Class=Asthma 33 conf:(1)

1296. Laboratory Procedure=screening Body Space or Junction=oral Individual Beh avior=visit 33 ==> Disease-Class=Asthma 33 conf:(1) 1297. Temporal Concept=prior to NUMERAL=1.0 Disease or Syndrome=asthma Individu al Behavior=visit 33 ==> Disease-Class=Asthma 33 conf:(1) 1298. Clinical Attribute=exposure to 32 ==> Disease-Class=Asthma 32 conf:(1) 1299. Qualitative Concept=effective 32 ==> Disease-Class=Asthma 32 conf:(1) 1300. Qualitative Concept=combination 32 ==> Disease-Class=Asthma 32 conf:(1 ) 1301. Therapeutic or Preventive Procedure=regimen 32 ==> Disease-Class=Asthma 3 2 conf:(1) 1302. Disease or Syndrome=cystic fibrosis 32 ==> Disease-Class=Asthma 32 con f:(1) 1303. Body Location or Region=nebulized 32 ==> Disease-Class=Asthma 32 conf: (1) 1304. Activity=obtained 32 ==> Disease-Class=Asthma 32 conf:(1) 1305. Medical Device=inhaler 32 ==> Disease-Class=Asthma 32 conf:(1) 1306. Patient or Disabled Group=patients Diagnostic Procedure=fev1 32 ==> Disea se-Class=Asthma 32 conf:(1) 1307. Health Care Activity=diagnosis NUMERAL=6.0 32 ==> Disease-Class=Asthma 32 conf:(1) 1308. Health Care Activity=enrollment Research Activity=study 32 ==> Disease-Cl ass=Asthma 32 conf:(1) 1309. Health Care Activity=documented SYMBOL=- 32 ==> Disease-Class=Asthma 32 conf:(1) 1310. Health Care Activity=documented Individual Behavior=visit 32 ==> DiseaseClass=Asthma 32 conf:(1) 1311. Temporal Concept=years Functional Concept=inclusive 32 ==> Disease-Class= Asthma 32 conf:(1) 1312. Temporal Concept=days SYMBOL=- 32 ==> Disease-Class=Asthma 32 conf:(1) 1313. Temporal Concept=during Human=subject 32 ==> Disease-Class=Asthma 32 c onf:(1) 1314. Temporal Concept=period Laboratory Procedure=screening 32 ==> Disease-Cla ss=Asthma 32 conf:(1) 1315. Temporal Concept=chronic Qualitative Concept=other 32 ==> Disease-Class=A sthma 32 conf:(1) 1316. Temporal Concept=reversibility UNIT=% 32 ==> Disease-Class=Asthma 32 c onf:(1) 1317. Pharmacologic Substance=corticosteroids Research Activity=study 32 ==> Di sease-Class=Asthma 32 conf:(1) 1318. NO=exclusion criteria Disease or Syndrome=asthma 32 ==> Disease-Class=Ast hma 32 conf:(1) 1319. SYMBOL=> Quantitative Concept=mcg 32 ==> Disease-Class=Asthma 32 conf: (1) 1320. NUMERAL=10.0 Therapeutic or Preventive Procedure=ex 32 ==> Disease-Class= Asthma 32 conf:(1) 1321. NUMERAL=18.0 Age Group=ages 32 ==> Disease-Class=Asthma 32 conf:(1) 1322. NUMERAL=12.0 Age Group=ages 32 ==> Disease-Class=Asthma 32 conf:(1) 1323. NUMERAL=90.0 Diagnostic Procedure=fev1 32 ==> Disease-Class=Asthma 32 conf:(1) 1324. NUMERAL=11.0 Age Group=ages 32 ==> Disease-Class=Asthma 32 conf:(1) 1325. NUMERAL=50.0 Idea or Concept=eligible 32 ==> Disease-Class=Asthma 32 c onf:(1) 1326. Quantitative Concept=dose Spatial Concept=within 32 ==> Disease-Class=Ast hma 32 conf:(1) 1327. UNIT=% Spatial Concept=between 32 ==> Disease-Class=Asthma 32 conf:(1) 1328. Idea or Concept=predicted Qualitative Concept=normal 32 ==> Disease-Class =Asthma 32 conf:(1) 1329. Idea or Concept=opinion Human=subject 32 ==> Disease-Class=Asthma 32 c onf:(1) 1330. Research Activity=study Activity=put 32 ==> Disease-Class=Asthma 32 co

nf:(1) 1331. Population Group=american Organization=society 32 ==> Disease-Class=Asthm a 32 conf:(1) 1332. Diagnostic Procedure=fev1 Human=subjects 32 ==> Disease-Class=Asthma 32 conf:(1) 1333. Human=subjects Capacity=able to 32 ==> Disease-Class=Asthma 32 conf:(1 ) 1334. Human=subject Human-caused Phenomenon or Process=safety 32 ==> Disease-Cl ass=Asthma 32 conf:(1) 1335. Willing=willing Capacity=able to 32 ==> Disease-Class=Asthma 32 conf:( 1) 1336. Health Care Activity=apply NO=exclusion criteria SYMBOL=- 32 ==> DiseaseClass=Asthma 32 conf:(1) 1337. Temporal Concept=years NUMERAL=50.0 Idea or Concept=eligible 32 ==> Disea se-Class=Asthma 32 conf:(1) 1338. Temporal Concept=years NUMERAL=50.0 Research Activity=study 32 ==> Diseas e-Class=Asthma 32 conf:(1) 1339. Temporal Concept=years NUMERAL=50.0 Age Group=ages 32 ==> Disease-Class=A sthma 32 conf:(1) 1340. Temporal Concept=weeks SYMBOL=- Spatial Concept=within 32 ==> Disease-Cla ss=Asthma 32 conf:(1) 1341. Temporal Concept=weeks NUMERAL=1.0 Spatial Concept=within 32 ==> DiseaseClass=Asthma 32 conf:(1) 1342. Temporal Concept=before Laboratory Procedure=screening Individual Behavio r=visit 32 ==> Disease-Class=Asthma 32 conf:(1) 1343. Pharmacologic Substance=corticosteroids NUMERAL=1.0 Body Space or Junctio n=oral 32 ==> Disease-Class=Asthma 32 conf:(1) 1344. SYMBOL=- NUMERAL=4.0 Spatial Concept=within 32 ==> Disease-Class=Asthma 3 2 conf:(1) 1345. SYMBOL=- Spatial Concept=within Activity=inhaled 32 ==> Disease-Class=Ast hma 32 conf:(1) 1346. SYMBOL=>= Disease or Syndrome=asthma Laboratory Procedure=screening 32 == > Disease-Class=Asthma 32 conf:(1) 1347. NUMERAL=30.0 Research Activity=study Spatial Concept=within 32 ==> Diseas e-Class=Asthma 32 conf:(1) 1348. NUMERAL=50.0 Idea or Concept=eligible Research Activity=study 32 ==> Dise ase-Class=Asthma 32 conf:(1) 1349. NUMERAL=50.0 Idea or Concept=eligible Age Group=ages 32 ==> Disease-Class =Asthma 32 conf:(1) 1350. NUMERAL=50.0 Research Activity=study Age Group=ages 32 ==> Disease-Class= Asthma 32 conf:(1) 1351. Quantitative Concept=short Idea or Concept=acting Disease or Syndrome=ast hma 32 ==> Disease-Class=Asthma 32 conf:(1) 1352. UNIT=% Qualitative Concept=normal Diagnostic Procedure=fev1 32 ==> Diseas e-Class=Asthma 32 conf:(1) 1353. UNIT=% Diagnostic Procedure=fev1 Organic Chemical=methacholine 32 ==> Dis ease-Class=Asthma 32 conf:(1) 1354. Idea or Concept=predicted Laboratory Procedure=screening Diagnostic Proce dure=fev1 32 ==> Disease-Class=Asthma 32 conf:(1) 1355. Therapeutic or Preventive Procedure=treatment Spatial Concept=within Indi vidual Behavior=visit 32 ==> Disease-Class=Asthma 32 conf:(1) 1356. Therapeutic or Preventive Procedure=treatment Laboratory Procedure=screen ing Individual Behavior=visit 32 ==> Disease-Class=Asthma 32 conf:(1) 1357. Laboratory Procedure=screening Activity=inhaled Individual Behavior=visit 32 ==> Disease-Class=Asthma 32 conf:(1) 1358. Temporal Concept=years NUMERAL=50.0 Idea or Concept=eligible Research Act ivity=study 32 ==> Disease-Class=Asthma 32 conf:(1) 1359. Temporal Concept=years NUMERAL=50.0 Idea or Concept=eligible Age Group=ag es 32 ==> Disease-Class=Asthma 32 conf:(1) 1360. Temporal Concept=years NUMERAL=50.0 Research Activity=study Age Group=age

s 32 ==> Disease-Class=Asthma 32 conf:(1) 1361. Temporal Concept=weeks NUMERAL=1.0 Spatial Concept=within Individual Beha vior=visit 32 ==> Disease-Class=Asthma 32 conf:(1) 1362. Pharmacologic Substance=bronchodilator UNIT=% Idea or Concept=predicted D iagnostic Procedure=fev1 32 ==> Disease-Class=Asthma 32 conf:(1) 1363. NUMERAL=50.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 32 ==> Disease-Class=Asthma 32 conf:(1) 1364. UNIT=% Idea or Concept=predicted Laboratory Procedure=screening Diagnosti c Procedure=fev1 32 ==> Disease-Class=Asthma 32 conf:(1) 1365. Temporal Concept=years NUMERAL=50.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 32 ==> Disease-Class=Asthma 32 conf:(1) 1366. Pharmacologic Substance=omalizumab 31 ==> Disease-Class=Asthma 31 conf :(1) 1367. Quantitative Concept=three 31 ==> Disease-Class=Asthma 31 conf:(1) 1368. Quantitative Concept=could 31 ==> Disease-Class=Asthma 31 conf:(1) 1369. Qualitative Concept=determined by 31 ==> Disease-Class=Asthma 31 conf: (1) 1370. Functional Concept=limited 31 ==> Disease-Class=Asthma 31 conf:(1) 1371. Disease or Syndrome=allergic asthma 31 ==> Disease-Class=Asthma 31 con f:(1) 1372. Body System=cardiovascular 31 ==> Disease-Class=Asthma 31 conf:(1) 1373. Temporal Concept=years SYMBOL=> 31 ==> Disease-Class=Asthma 31 conf:(1 ) 1374. Temporal Concept=years NUMERAL=45.0 31 ==> Disease-Class=Asthma 31 con f:(1) 1375. Temporal Concept=days Research Activity=study 31 ==> Disease-Class=Asthma 31 conf:(1) 1376. Temporal Concept=current Disease or Syndrome=asthma 31 ==> Disease-Class= Asthma 31 conf:(1) 1377. Temporal Concept=prior to Qualitative Concept=last 31 ==> Disease-Class=A sthma 31 conf:(1) 1378. Temporal Concept=weeks NUMERAL=6.0 31 ==> Disease-Class=Asthma 31 conf :(1) 1379. Temporal Concept=period Spatial Concept=within 31 ==> Disease-Class=Asthm a 31 conf:(1) 1380. Temporal Concept=before NUMERAL=1.0 31 ==> Disease-Class=Asthma 31 con f:(1) 1381. Intellectual Product=criteria Research Activity=study 31 ==> Disease-Clas s=Asthma 31 conf:(1) 1382. Intellectual Product=method Functional Concept=using 31 ==> Disease-Class =Asthma 31 conf:(1) 1383. Pharmacologic Substance=bronchodilator Qualitative Concept=pre 31 ==> Dis ease-Class=Asthma 31 conf:(1) 1384. NO=no Individual Behavior=visit 31 ==> Disease-Class=Asthma 31 conf:(1 ) 1385. SYMBOL=- Qualitative Concept=last 31 ==> Disease-Class=Asthma 31 conf: (1) 1386. SYMBOL=- Functional Concept=increase 31 ==> Disease-Class=Asthma 31 co nf:(1) 1387. SYMBOL=- Capacity=able to 31 ==> Disease-Class=Asthma 31 conf:(1) 1388. SYMBOL=< NUMERAL=1.0 31 ==> Disease-Class=Asthma 31 conf:(1) 1389. SYMBOL=< Quantitative Concept=ml 31 ==> Disease-Class=Asthma 31 conf:( 1) 1390. SYMBOL=< Human=subjects 31 ==> Disease-Class=Asthma 31 conf:(1) 1391. Quantitative Concept=exacerbation Functional Concept=requiring 31 ==> Dis ease-Class=Asthma 31 conf:(1) 1392. Quantitative Concept=equivalent Activity=inhaled 31 ==> Disease-Class=Ast hma 31 conf:(1) 1393. Quantitative Concept=dose Laboratory Procedure=screening 31 ==> Disease-C lass=Asthma 31 conf:(1)

1394. Quantitative Concept=value Idea or Concept=predicted 31 ==> Disease-Class =Asthma 31 conf:(1) 1395. Idea or Concept=acting Spatial Concept=within 31 ==> Disease-Class=Asthma 31 conf:(1) 1396. Research Activity=study Organism Function=pregnant 31 ==> Disease-Class=A sthma 31 conf:(1) 1397. Qualitative Concept=last Body Space or Junction=oral 31 ==> Disease-Class =Asthma 31 conf:(1) 1398. Functional Concept=including Individual Behavior=visit 31 ==> Disease-Cla ss=Asthma 31 conf:(1) 1399. Functional Concept=use Human=subjects 31 ==> Disease-Class=Asthma 31 c onf:(1) 1400. Functional Concept=using Contraception=contraception 31 ==> Disease-Class =Asthma 31 conf:(1) 1401. Spatial Concept=within Disease or Syndrome=respiratory tract infection 31 ==> Disease-Class=Asthma 31 conf:(1) 1402. Spatial Concept=within Finding=lives 31 ==> Disease-Class=Asthma 31 co nf:(1) 1403. Disease or Syndrome=thoracic Organization=society 31 ==> Disease-Class=As thma 31 conf:(1) 1404. Health Care Related Organization=emergency room Individual Behavior=visit 31 ==> Disease-Class=Asthma 31 conf:(1) 1405. Patient or Disabled Group=patients UNIT=% Diagnostic Procedure=fev1 31 == > Disease-Class=Asthma 31 conf:(1) 1406. Patient or Disabled Group=patients Laboratory Procedure=screening Individ ual Behavior=visit 31 ==> Disease-Class=Asthma 31 conf:(1) 1407. Health Care Activity=hospitalization Spatial Concept=within Disease or Sy ndrome=asthma 31 ==> Disease-Class=Asthma 31 conf:(1) 1408. Temporal Concept=prior to NUMERAL=4.0 Laboratory Procedure=screening 31 = => Disease-Class=Asthma 31 conf:(1) 1409. Temporal Concept=prior to Research Activity=entry Disease or Syndrome=ast hma 31 ==> Disease-Class=Asthma 31 conf:(1) 1410. Temporal Concept=prior to Therapeutic or Preventive Procedure=treatment I ndividual Behavior=visit 31 ==> Disease-Class=Asthma 31 conf:(1) 1411. Temporal Concept=months SYMBOL=- Spatial Concept=within 31 ==> Disease-Cl ass=Asthma 31 conf:(1) 1412. NO=not SYMBOL=- Human=subject 31 ==> Disease-Class=Asthma 31 conf:(1) 1413. SYMBOL=- Disease or Syndrome=asthma Human=subject 31 ==> Disease-Class=As thma 31 conf:(1) 1414. NUMERAL=10.0 Quantitative Concept=pack Finding=smoking history 31 ==> Dis ease-Class=Asthma 31 conf:(1) 1415. NUMERAL=4.0 Spatial Concept=within Disease or Syndrome=asthma 31 ==> Dise ase-Class=Asthma 31 conf:(1) 1416. NUMERAL=4.0 Laboratory Procedure=screening Individual Behavior=visit 31 = => Disease-Class=Asthma 31 conf:(1) 1417. NUMERAL=1.0 UNIT=% Individual Behavior=visit 31 ==> Disease-Class=Asthma 31 conf:(1) 1418. NUMERAL=90.0 UNIT=% Diagnostic Procedure=fev1 31 ==> Disease-Class=Asthma 31 conf:(1) 1419. Spatial Concept=within Individual Behavior=visit Human=subjects 31 ==> Di sease-Class=Asthma 31 conf:(1) 1420. Temporal Concept=previously 30 ==> Disease-Class=Asthma 30 conf:(1) 1421. Intellectual Product=until 30 ==> Disease-Class=Asthma 30 conf:(1) 1422. Qualitative Concept=longer 30 ==> Disease-Class=Asthma 30 conf:(1) 1423. Qualitative Concept=moderate 30 ==> Disease-Class=Asthma 30 conf:(1) 1424. Gene or Genome=am 30 ==> Disease-Class=Asthma 30 conf:(1) 1425. Disease or Syndrome=illness 30 ==> Disease-Class=Asthma 30 conf:(1) 1426. Activity=receipt 30 ==> Disease-Class=Asthma 30 conf:(1) 1427. Mental Process=judgment 30 ==> Disease-Class=Asthma 30 conf:(1) 1428. Health Care Activity=documented Spatial Concept=within 30 ==> Disease-Cla

ss=Asthma 30 conf:(1) 1429. Temporal Concept=history of Qualitative Concept=other 30 ==> Disease-Clas s=Asthma 30 conf:(1) 1430. Temporal Concept=year SYMBOL=- 30 ==> Disease-Class=Asthma 30 conf:(1) 1431. Temporal Concept=before Disease or Syndrome=asthma 30 ==> Disease-Class=A sthma 30 conf:(1) 1432. Intellectual Product=pack years Spatial Concept=within 30 ==> Disease-Cla ss=Asthma 30 conf:(1) 1433. Pharmacologic Substance=agonists Qualitative Concept=beta 30 ==> DiseaseClass=Asthma 30 conf:(1) 1434. Pharmacologic Substance=steroids Functional Concept=use of 30 ==> Disease -Class=Asthma 30 conf:(1) 1435. NO=not Organism Attribute=female 30 ==> Disease-Class=Asthma 30 conf:( 1) 1436. NO=not Professional or Occupational Group=investigator 30 ==> Disease-Cla ss=Asthma 30 conf:(1) 1437. SYMBOL=- Qualitative Concept=protocol 30 ==> Disease-Class=Asthma 30 c onf:(1) 1438. SYMBOL=> NUMERAL=2.0 30 ==> Disease-Class=Asthma 30 conf:(1) 1439. SYMBOL=> Sign or Symptom=symptoms 30 ==> Disease-Class=Asthma 30 conf: (1) 1440. SYMBOL=> Human=subjects 30 ==> Disease-Class=Asthma 30 conf:(1) 1441. SYMBOL=<= UNIT=% 30 ==> Disease-Class=Asthma 30 conf:(1) 1442. NUMERAL=10.0 Behavior Problem=smokers 30 ==> Disease-Class=Asthma 30 c onf:(1) 1443. NUMERAL=12.0 Diagnostic Procedure=fev1 30 ==> Disease-Class=Asthma 30 conf:(1) 1444. Idea or Concept=predicted Disease or Syndrome=asthma 30 ==> Disease-Class =Asthma 30 conf:(1) 1445. Research Activity=randomization Spatial Concept=within 30 ==> Disease-Cla ss=Asthma 30 conf:(1) 1446. Research Activity=gina Social Behavior=according 30 ==> Disease-Class=Ast hma 30 conf:(1) 1447. Functional Concept=provide Regulation or Law=informed consent 30 ==> Dise ase-Class=Asthma 30 conf:(1) 1448. Spatial Concept=between Diagnostic Procedure=fev1 30 ==> Disease-Class=As thma 30 conf:(1) 1449. Spatial Concept=within Disease or Syndrome=lower respiratory tract infect ion 30 ==> Disease-Class=Asthma 30 conf:(1) 1450. Laboratory Procedure=screening Professional or Occupational Group=investi gator 30 ==> Disease-Class=Asthma 30 conf:(1) 1451. Professional or Occupational Group=investigator Activity=interfere 30 ==> Disease-Class=Asthma 30 conf:(1) 1452. Professional or Occupational Group=investigator Activity=put 30 ==> Disea se-Class=Asthma 30 conf:(1) 1453. Diagnostic Procedure=fev1 Activity=inhaled 30 ==> Disease-Class=Asthma 30 conf:(1) 1454. Temporal Concept=years Organism Attribute=female Age Group=aged 30 ==> Di sease-Class=Asthma 30 conf:(1) 1455. Temporal Concept=prior to NUMERAL=1.0 Laboratory Procedure=screening 30 = => Disease-Class=Asthma 30 conf:(1) 1456. Temporal Concept=weeks NUMERAL=4.0 Disease or Syndrome=asthma 30 ==> Dise ase-Class=Asthma 30 conf:(1) 1457. Pharmacologic Substance=corticosteroids NUMERAL=1.0 Individual Behavior=v isit 30 ==> Disease-Class=Asthma 30 conf:(1) 1458. Pharmacologic Substance=corticosteroids Therapeutic or Preventive Procedu re=treatment Body Space or Junction=oral 30 ==> Disease-Class=Asthma 30 conf: (1) 1459. SYMBOL=- Research Activity=study Professional or Occupational Group=inves tigator 30 ==> Disease-Class=Asthma 30 conf:(1)

1460. SYMBOL=- Functional Concept=non Behavior Problem=smokers 30 ==> Disease-C lass=Asthma 30 conf:(1) 1461. SYMBOL=- Disease or Syndrome=asthma Professional or Occupational Group=ph ysician 30 ==> Disease-Class=Asthma 30 conf:(1) 1462. SYMBOL=>= UNIT=% Laboratory Procedure=screening 30 ==> Disease-Class=Asth ma 30 conf:(1) 1463. NUMERAL=12.0 UNIT=% Diagnostic Procedure=fev1 30 ==> Disease-Class=Asthma 30 conf:(1) 1464. NUMERAL=12.0 Research Activity=study Age Group=ages 30 ==> Disease-Class= Asthma 30 conf:(1) 1465. Quantitative Concept=ml UNIT=% Diagnostic Procedure=fev1 30 ==> Disease-C lass=Asthma 30 conf:(1) 1466. Quantitative Concept=short Idea or Concept=acting Qualitative Concept=bet a 30 ==> Disease-Class=Asthma 30 conf:(1) 1467. UNIT=% Idea or Concept=predicted Qualitative Concept=normal 30 ==> Diseas e-Class=Asthma 30 conf:(1) 1468. NUMERAL=40.0 29 ==> Disease-Class=Asthma 29 conf:(1) 1469. Idea or Concept=expected 29 ==> Disease-Class=Asthma 29 conf:(1) 1470. Functional Concept=additional 29 ==> Disease-Class=Asthma 29 conf:(1) 1471. Spatial Concept=under 29 ==> Disease-Class=Asthma 29 conf:(1) 1472. Spatial Concept=above 29 ==> Disease-Class=Asthma 29 conf:(1) 1473. Disease or Syndrome=hfa 29 ==> Disease-Class=Asthma 29 conf:(1) 1474. Organ or Tissue Function=pulmonary function 29 ==> Disease-Class=Asthma 2 9 conf:(1) 1475. Sign or Symptom=sign 29 ==> Disease-Class=Asthma 29 conf:(1) 1476. Diagnostic Procedure=clinical diagnosis 29 ==> Disease-Class=Asthma 29 conf:(1) 1477. Behavior Problem=abstinence 29 ==> Disease-Class=Asthma 29 conf:(1) 1478. Patient or Disabled Group=patients Temporal Concept=months 29 ==> Disease -Class=Asthma 29 conf:(1) 1479. Patient or Disabled Group=patient SYMBOL=>= 29 ==> Disease-Class=Asthma 2 9 conf:(1) 1480. Health Care Activity=apply Qualitative Concept=inclusion 29 ==> Disease-C lass=Asthma 29 conf:(1) 1481. Temporal Concept=years NUMERAL=17.0 29 ==> Disease-Class=Asthma 29 con f:(1) 1482. Temporal Concept=days Functional Concept=use of 29 ==> Disease-Class=Asth ma 29 conf:(1) 1483. Temporal Concept=history of Qualitative Concept=significant 29 ==> Diseas e-Class=Asthma 29 conf:(1) 1484. NO=not SYMBOL=> 29 ==> Disease-Class=Asthma 29 conf:(1) 1485. SYMBOL=- Therapeutic or Preventive Procedure=intubation 29 ==> Disease-Cl ass=Asthma 29 conf:(1) 1486. NUMERAL=6.0 Human=subjects 29 ==> Disease-Class=Asthma 29 conf:(1) 1487. NUMERAL=2.0 Therapeutic or Preventive Procedure=treatment 29 ==> DiseaseClass=Asthma 29 conf:(1) 1488. NUMERAL=4.0 Quantitative Concept=exacerbation 29 ==> Disease-Class=Asthma 29 conf:(1) 1489. NUMERAL=12.0 Human=subject 29 ==> Disease-Class=Asthma 29 conf:(1) 1490. NUMERAL=11.0 Idea or Concept=eligible 29 ==> Disease-Class=Asthma 29 c onf:(1) 1491. NUMERAL=11.0 Research Activity=study 29 ==> Disease-Class=Asthma 29 co nf:(1) 1492. Quantitative Concept=exacerbation Laboratory Procedure=screening 29 ==> D isease-Class=Asthma 29 conf:(1) 1493. Laboratory or Test Result=pc20 Diagnostic Procedure=fev1 29 ==> Disease-C lass=Asthma 29 conf:(1) 1494. Research Activity=study Individual Behavior=visits 29 ==> Disease-Class=A sthma 29 conf:(1) 1495. Qualitative Concept=acceptable Functional Concept=using 29 ==> Disease-Cl

ass=Asthma 29 conf:(1) 1496. Qualitative Concept=has Laboratory Procedure=screening 29 ==> Disease-Cla ss=Asthma 29 conf:(1) 1497. Population Group=american Disease or Syndrome=thoracic 29 ==> Disease-Cla ss=Asthma 29 conf:(1) 1498. Functional Concept=systemic Laboratory Procedure=screening 29 ==> Disease -Class=Asthma 29 conf:(1) 1499. Functional Concept=based Disease or Syndrome=asthma 29 ==> Disease-Class= Asthma 29 conf:(1) 1500. Disease or Syndrome=ics Laboratory Procedure=screening 29 ==> Disease-Cla ss=Asthma 29 conf:(1) 1501. Patient or Disabled Group=patients SYMBOL=- Disease or Syndrome=asthma 29 ==> Disease-Class=Asthma 29 conf:(1) 1502. Health Care Activity=diagnosis Temporal Concept=months Disease or Syndrom e=asthma 29 ==> Disease-Class=Asthma 29 conf:(1) 1503. Temporal Concept=years SYMBOL=- Finding=smoking history 29 ==> Disease-Cl ass=Asthma 29 conf:(1) 1504. Temporal Concept=years NUMERAL=18.0 Age Group=age 29 ==> Disease-Class=As thma 29 conf:(1) 1505. Temporal Concept=years NUMERAL=12.0 Age Group=ages 29 ==> Disease-Class=A sthma 29 conf:(1) 1506. Temporal Concept=years NUMERAL=11.0 Idea or Concept=eligible 29 ==> Disea se-Class=Asthma 29 conf:(1) 1507. Temporal Concept=years NUMERAL=11.0 Research Activity=study 29 ==> Diseas e-Class=Asthma 29 conf:(1) 1508. Temporal Concept=years NUMERAL=11.0 Age Group=ages 29 ==> Disease-Class=A sthma 29 conf:(1) 1509. Temporal Concept=prior to NUMERAL=4.0 Spatial Concept=within 29 ==> Disea se-Class=Asthma 29 conf:(1) 1510. Temporal Concept=prior to Quantitative Concept=exacerbation Disease or Sy ndrome=asthma 29 ==> Disease-Class=Asthma 29 conf:(1) 1511. Temporal Concept=prior to Laboratory Procedure=screening Activity=inhaled 29 ==> Disease-Class=Asthma 29 conf:(1) 1512. Temporal Concept=weeks NUMERAL=4.0 Qualitative Concept=last 29 ==> Diseas e-Class=Asthma 29 conf:(1) 1513. Temporal Concept=months SYMBOL=>= NUMERAL=12.0 29 ==> Disease-Class=Asthm a 29 conf:(1) 1514. Temporal Concept=months Research Activity=study Spatial Concept=within 29 ==> Disease-Class=Asthma 29 conf:(1) 1515. Temporal Concept=months Spatial Concept=within Laboratory Procedure=scree ning 29 ==> Disease-Class=Asthma 29 conf:(1) 1516. Pharmacologic Substance=albuterol UNIT=% Diagnostic Procedure=fev1 29 ==> Disease-Class=Asthma 29 conf:(1) 1517. Pharmacologic Substance=medication SYMBOL=- Research Activity=study 29 == > Disease-Class=Asthma 29 conf:(1) 1518. Pharmacologic Substance=corticosteroids Functional Concept=use of Body Sp ace or Junction=oral 29 ==> Disease-Class=Asthma 29 conf:(1) 1519. Pharmacologic Substance=corticosteroids Spatial Concept=within Activity=i nhaled 29 ==> Disease-Class=Asthma 29 conf:(1) 1520. SYMBOL=- NUMERAL=5.0 Spatial Concept=within 29 ==> Disease-Class=Asthma 2 9 conf:(1) 1521. SYMBOL=- Quantitative Concept=short Activity=inhaled 29 ==> Disease-Class =Asthma 29 conf:(1) 1522. SYMBOL=- Spatial Concept=within Body Space or Junction=oral 29 ==> Diseas e-Class=Asthma 29 conf:(1) 1523. SYMBOL=- Spatial Concept=within Human=subject 29 ==> Disease-Class=Asthma 29 conf:(1) 1524. NUMERAL=3.0 Spatial Concept=within Disease or Syndrome=asthma 29 ==> Dise ase-Class=Asthma 29 conf:(1) 1525. NUMERAL=12.0 Idea or Concept=eligible Age Group=ages 29 ==> Disease-Class

=Asthma 29 conf:(1) 1526. NUMERAL=11.0 Idea or Concept=eligible Research Activity=study 29 ==> Dise ase-Class=Asthma 29 conf:(1) 1527. NUMERAL=11.0 Idea or Concept=eligible Age Group=ages 29 ==> Disease-Class =Asthma 29 conf:(1) 1528. NUMERAL=11.0 Research Activity=study Age Group=ages 29 ==> Disease-Class= Asthma 29 conf:(1) 1529. Quantitative Concept=value UNIT=% Idea or Concept=predicted 29 ==> Diseas e-Class=Asthma 29 conf:(1) 1530. UNIT=% Idea or Concept=predicted Disease or Syndrome=asthma 29 ==> Diseas e-Class=Asthma 29 conf:(1) 1531. UNIT=% Diagnostic Procedure=fev1 Human=subjects 29 ==> Disease-Class=Asth ma 29 conf:(1) 1532. Idea or Concept=opinion Research Activity=study Individual Behavior=parti cipation 29 ==> Disease-Class=Asthma 29 conf:(1) 1533. Research Activity=study Finding=written Regulation or Law=informed consen t 29 ==> Disease-Class=Asthma 29 conf:(1) 1534. Population Group=american Disease or Syndrome=thoracic Organization=socie ty 29 ==> Disease-Class=Asthma 29 conf:(1) 1535. Spatial Concept=within Disease or Syndrome=asthma Human=subject 29 ==> Di sease-Class=Asthma 29 conf:(1) 1536. Temporal Concept=years NUMERAL=11.0 Idea or Concept=eligible Research Act ivity=study 29 ==> Disease-Class=Asthma 29 conf:(1) 1537. Temporal Concept=years NUMERAL=11.0 Idea or Concept=eligible Age Group=ag es 29 ==> Disease-Class=Asthma 29 conf:(1) 1538. Temporal Concept=years NUMERAL=11.0 Research Activity=study Age Group=age s 29 ==> Disease-Class=Asthma 29 conf:(1) 1539. SYMBOL=- NUMERAL=10.0 Quantitative Concept=pack Finding=smoking history 2 9 ==> Disease-Class=Asthma 29 conf:(1) 1540. SYMBOL=- NUMERAL=1.0 Spatial Concept=within Individual Behavior=visit 29 ==> Disease-Class=Asthma 29 conf:(1) 1541. SYMBOL=- Quantitative Concept=short Idea or Concept=acting Activity=inhal ed 29 ==> Disease-Class=Asthma 29 conf:(1) 1542. NUMERAL=12.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 29 ==> Disease-Class=Asthma 29 conf:(1) 1543. NUMERAL=11.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 29 ==> Disease-Class=Asthma 29 conf:(1) 1544. Temporal Concept=years NUMERAL=11.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 29 ==> Disease-Class=Asthma 29 conf:(1) 1545. Health Care Activity=evaluation 28 ==> Disease-Class=Asthma 28 conf:(1 ) 1546. Temporal Concept=prior 28 ==> Disease-Class=Asthma 28 conf:(1) 1547. Pharmacologic Substance=bronchodilators 28 ==> Disease-Class=Asthma 28 conf:(1) 1548. NUMERAL=24.0 28 ==> Disease-Class=Asthma 28 conf:(1) 1549. NUMERAL=1000.0 28 ==> Disease-Class=Asthma 28 conf:(1) 1550. NUMERAL=??????2 28 ==> Disease-Class=Asthma 28 conf:(1) 1551. Qualitative Concept=major 28 ==> Disease-Class=Asthma 28 conf:(1) 1552. Qualitative Concept=consecutive 28 ==> Disease-Class=Asthma 28 conf:(1 ) 1553. Therapeutic or Preventive Procedure=surgery 28 ==> Disease-Class=Asthma 2 8 conf:(1) 1554. Organism Function=menopausal 28 ==> Disease-Class=Asthma 28 conf:(1) 1555. Mental Process=experienced 28 ==> Disease-Class=Asthma 28 conf:(1) 1556. Other Study=participation in another 28 ==> Disease-Class=Asthma 28 co nf:(1) 1557. Patient or Disabled Group=patients Pharmacologic Substance=medication 28 ==> Disease-Class=Asthma 28 conf:(1) 1558. Health Care Activity=meet Intellectual Product=criteria 28 ==> Disease-Cl ass=Asthma 28 conf:(1)

1559. Temporal Concept=years NUMERAL=2.0 28 ==> Disease-Class=Asthma 28 conf :(1) 1560. Temporal Concept=during NO=not 28 ==> Disease-Class=Asthma 28 conf:(1) 1561. Temporal Concept=weeks Quantitative Concept=exacerbation 28 ==> Disease-C lass=Asthma 28 conf:(1) 1562. Temporal Concept=months Human=subjects 28 ==> Disease-Class=Asthma 28 conf:(1) 1563. Pharmacologic Substance=medications Research Activity=study 28 ==> Diseas e-Class=Asthma 28 conf:(1) 1564. Pharmacologic Substance=salbutamol Diagnostic Procedure=fev1 28 ==> Disea se-Class=Asthma 28 conf:(1) 1565. SYMBOL=- NUMERAL=60.0 28 ==> Disease-Class=Asthma 28 conf:(1) 1566. SYMBOL=- Quantitative Concept=puffs 28 ==> Disease-Class=Asthma 28 con f:(1) 1567. SYMBOL=- UNIT=time 28 ==> Disease-Class=Asthma 28 conf:(1) 1568. SYMBOL=- Qualitative Concept=acceptable 28 ==> Disease-Class=Asthma 28 conf:(1) 1569. SYMBOL=- Qualitative Concept=has 28 ==> Disease-Class=Asthma 28 conf:( 1) 1570. SYMBOL=- Qualitative Concept=beta2 28 ==> Disease-Class=Asthma 28 conf :(1) 1571. SYMBOL=- Population Group=women 28 ==> Disease-Class=Asthma 28 conf:(1 ) 1572. SYMBOL=- Geographic Area=ie 28 ==> Disease-Class=Asthma 28 conf:(1) 1573. SYMBOL=< Laboratory Procedure=screening 28 ==> Disease-Class=Asthma 28 conf:(1) 1574. NUMERAL=6.0 Activity=inhaled 28 ==> Disease-Class=Asthma 28 conf:(1) 1575. NUMERAL=30.0 Laboratory Procedure=screening 28 ==> Disease-Class=Asthma 2 8 conf:(1) 1576. NUMERAL=1.0 Quantitative Concept=exacerbation 28 ==> Disease-Class=Asthma 28 conf:(1) 1577. Quantitative Concept=baseline Disease or Syndrome=asthma 28 ==> Disease-C lass=Asthma 28 conf:(1) 1578. Quantitative Concept=short Individual Behavior=visit 28 ==> Disease-Class =Asthma 28 conf:(1) 1579. UNIT=% Therapeutic or Preventive Procedure=administration 28 ==> DiseaseClass=Asthma 28 conf:(1) 1580. UNIT=% Human=subject 28 ==> Disease-Class=Asthma 28 conf:(1) 1581. Organism Attribute=female Idea or Concept=eligible 28 ==> Disease-Class=A sthma 28 conf:(1) 1582. Organism Attribute=female Contraception=contraception 28 ==> Disease-Clas s=Asthma 28 conf:(1) 1583. Research Activity=study Qualitative Concept=significant 28 ==> Disease-Cl ass=Asthma 28 conf:(1) 1584. Research Activity=study Contraception=contraception 28 ==> Disease-Class= Asthma 28 conf:(1) 1585. Qualitative Concept=other Spatial Concept=within 28 ==> Disease-Class=Ast hma 28 conf:(1) 1586. Qualitative Concept=from Human=subject 28 ==> Disease-Class=Asthma 28 conf:(1) 1587. Functional Concept=use Contraception=contraception 28 ==> Disease-Class=A sthma 28 conf:(1) 1588. Functional Concept=systemic Disease or Syndrome=asthma 28 ==> Disease-Cla ss=Asthma 28 conf:(1) 1589. Professional or Occupational Group=investigator Human=subjects 28 ==> Dis ease-Class=Asthma 28 conf:(1) 1590. Professional or Occupational Group=investigator Capacity=ability 28 ==> D isease-Class=Asthma 28 conf:(1) 1591. Human=subject Capacity=able to 28 ==> Disease-Class=Asthma 28 conf:(1) 1592. Patient or Disabled Group=patients Temporal Concept=years Organism Attrib

ute=female 28 ==> Disease-Class=Asthma 28 conf:(1) 1593. Temporal Concept=years SYMBOL=- Age Group=aged 28 ==> Disease-Class=Asthm a 28 conf:(1) 1594. Temporal Concept=prior to Therapeutic or Preventive Procedure=treatment D isease or Syndrome=asthma 28 ==> Disease-Class=Asthma 28 conf:(1) 1595. Temporal Concept=prior to Spatial Concept=within Human=subject 28 ==> Dis ease-Class=Asthma 28 conf:(1) 1596. Temporal Concept=prior to Activity=inhaled Individual Behavior=visit 28 = => Disease-Class=Asthma 28 conf:(1) 1597. Temporal Concept=months NUMERAL=3.0 Qualitative Concept=last 28 ==> Disea se-Class=Asthma 28 conf:(1) 1598. Temporal Concept=months NUMERAL=12.0 Spatial Concept=within 28 ==> Diseas e-Class=Asthma 28 conf:(1) 1599. Pharmacologic Substance=agonists SYMBOL=- Idea or Concept=acting 28 ==> D isease-Class=Asthma 28 conf:(1) 1600. Pharmacologic Substance=corticosteroids Therapeutic or Preventive Procedu re=treatment Activity=inhaled 28 ==> Disease-Class=Asthma 28 conf:(1) 1601. NO=not NUMERAL=1.0 Spatial Concept=within 28 ==> Disease-Class=Asthma 28 conf:(1) 1602. NO=not Spatial Concept=within Individual Behavior=visit 28 ==> Disease-Cl ass=Asthma 28 conf:(1) 1603. NO=not Individual Behavior=visit Human=subject 28 ==> Disease-Class=Asthm a 28 conf:(1) 1604. SYMBOL=- Research Activity=study Human=subjects 28 ==> Disease-Class=Asth ma 28 conf:(1) 1605. NUMERAL=6.0 Research Activity=study Spatial Concept=within 28 ==> Disease -Class=Asthma 28 conf:(1) 1606. NUMERAL=18.0 Idea or Concept=eligible Age Group=ages 28 ==> Disease-Class =Asthma 28 conf:(1) 1607. NUMERAL=18.0 Research Activity=study Age Group=ages 28 ==> Disease-Class= Asthma 28 conf:(1) 1608. UNIT=% Spatial Concept=between Diagnostic Procedure=fev1 28 ==> Disease-C lass=Asthma 28 conf:(1) 1609. Therapeutic or Preventive Procedure=treatment Disease or Syndrome=asthma Activity=inhaled 28 ==> Disease-Class=Asthma 28 conf:(1) 1610. Spatial Concept=within Laboratory Procedure=screening Human=subject 28 == > Disease-Class=Asthma 28 conf:(1) 1611. Spatial Concept=within Activity=inhaled Individual Behavior=visit 28 ==> Disease-Class=Asthma 28 conf:(1) 1612. Temporal Concept=years NUMERAL=12.0 Idea or Concept=eligible Age Group=ag es 28 ==> Disease-Class=Asthma 28 conf:(1) 1613. Temporal Concept=years NUMERAL=12.0 Research Activity=study Age Group=age s 28 ==> Disease-Class=Asthma 28 conf:(1) 1614. Temporal Concept=prior to Spatial Concept=within Disease or Syndrome=asth ma Individual Behavior=visit 28 ==> Disease-Class=Asthma 28 conf:(1) 1615. NUMERAL=18.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 28 ==> Disease-Class=Asthma 28 conf:(1) 1616. Temporal Concept=years NUMERAL=12.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 28 ==> Disease-Class=Asthma 28 conf:(1) 1617. Temporal Concept=acute 27 ==> Disease-Class=Asthma 27 conf:(1) 1618. Pharmacologic Substance=xolair 27 ==> Disease-Class=Asthma 27 conf:(1) 1619. NUMERAL=85.0 27 ==> Disease-Class=Asthma 27 conf:(1) 1620. NUMERAL=200.0 27 ==> Disease-Class=Asthma 27 conf:(1) 1621. Quantitative Concept=doses 27 ==> Disease-Class=Asthma 27 conf:(1) 1622. Idea or Concept=requirement 27 ==> Disease-Class=Asthma 27 conf:(1) 1623. Functional Concept=requires 27 ==> Disease-Class=Asthma 27 conf:(1) 1624. Pathologic Function=hypoxic 27 ==> Disease-Class=Asthma 27 conf:(1) 1625. Sign or Symptom=seizures 27 ==> Disease-Class=Asthma 27 conf:(1) 1626. Sign or Symptom=wheezing 27 ==> Disease-Class=Asthma 27 conf:(1) 1627. Health Care Related Organization=hospitalized 27 ==> Disease-Class=Asthma

27 conf:(1) 1628. Body System=skin 27 ==> Disease-Class=Asthma 27 conf:(1) 1629. Health Care Activity=hospitalization Laboratory Procedure=screening 27 == > Disease-Class=Asthma 27 conf:(1) 1630. Temporal Concept=years Organism Attribute=females 27 ==> Disease-Class=As thma 27 conf:(1) 1631. Temporal Concept=days NUMERAL=7.0 27 ==> Disease-Class=Asthma 27 conf: (1) 1632. Temporal Concept=days Laboratory Procedure=screening 27 ==> Disease-Class =Asthma 27 conf:(1) 1633. Temporal Concept=prior to Quantitative Concept=baseline 27 ==> Disease-Cl ass=Asthma 27 conf:(1) 1634. Temporal Concept=prior to Functional Concept=start 27 ==> Disease-Class=A sthma 27 conf:(1) 1635. Temporal Concept=prior to Disease or Syndrome=ics 27 ==> Disease-Class=As thma 27 conf:(1) 1636. Temporal Concept=year Finding=smoking history 27 ==> Disease-Class=Asthma 27 conf:(1) 1637. Clinical Attribute=parenteral Pharmacologic Substance=corticosteroids 27 ==> Disease-Class=Asthma 27 conf:(1) 1638. Pharmacologic Substance=steroids Spatial Concept=within 27 ==> Disease-Cl ass=Asthma 27 conf:(1) 1639. Pharmacologic Substance=agonist Quantitative Concept=short 27 ==> Disease -Class=Asthma 27 conf:(1) 1640. Pharmacologic Substance=drug SYMBOL=- 27 ==> Disease-Class=Asthma 27 c onf:(1) 1641. NO=exclusion criteria Qualitative Concept=inclusion 27 ==> Disease-Class= Asthma 27 conf:(1) 1642. NO=not Population Group=women 27 ==> Disease-Class=Asthma 27 conf:(1) 1643. SYMBOL=- Quantitative Concept=one 27 ==> Disease-Class=Asthma 27 conf: (1) 1644. SYMBOL=- Research Activity=randomization 27 ==> Disease-Class=Asthma 27 conf:(1) 1645. SYMBOL=- Organism Function=pregnant 27 ==> Disease-Class=Asthma 27 con f:(1) 1646. SYMBOL=- Finding=lives 27 ==> Disease-Class=Asthma 27 conf:(1) 1647. SYMBOL=- Body Location or Region=chest 27 ==> Disease-Class=Asthma 27 conf:(1) 1648. SYMBOL=- Contraception=contraception 27 ==> Disease-Class=Asthma 27 co nf:(1) 1649. SYMBOL=> NUMERAL=12.0 27 ==> Disease-Class=Asthma 27 conf:(1) 1650. SYMBOL== Idea or Concept=predicted 27 ==> Disease-Class=Asthma 27 conf :(1) 1651. NUMERAL=1.0 Diagnostic Procedure=fev1 27 ==> Disease-Class=Asthma 27 c onf:(1) 1652. Qualitative Concept=significant Spatial Concept=within 27 ==> Disease-Cla ss=Asthma 27 conf:(1) 1653. Qualitative Concept=has Individual Behavior=visit 27 ==> Disease-Class=As thma 27 conf:(1) 1654. Population Group=women Organism Function=childbearing 27 ==> Disease-Clas s=Asthma 27 conf:(1) 1655. Population Group=women Contraception=contraception 27 ==> Disease-Class=A sthma 27 conf:(1) 1656. Therapeutic or Preventive Procedure=intubation Finding=life 27 ==> Diseas e-Class=Asthma 27 conf:(1) 1657. Functional Concept=including Laboratory Procedure=screening 27 ==> Diseas e-Class=Asthma 27 conf:(1) 1658. Disease or Syndrome=asthma Professional or Occupational Group=investigato r 27 ==> Disease-Class=Asthma 27 conf:(1) 1659. Disease or Syndrome=asthma Health Care Related Organization=emergency roo

m 27 ==> Disease-Class=Asthma 27 conf:(1) 1660. Diagnostic Procedure=fev1 Human=subject 27 ==> Disease-Class=Asthma 27 conf:(1) 1661. Capacity=able to Compliance=comply 27 ==> Disease-Class=Asthma 27 conf :(1) 1662. Health Care Activity=diagnosis NUMERAL=6.0 Disease or Syndrome=asthma 27 ==> Disease-Class=Asthma 27 conf:(1) 1663. Temporal Concept=years NUMERAL=10.0 Spatial Concept=within 27 ==> Disease -Class=Asthma 27 conf:(1) 1664. Temporal Concept=years NUMERAL=18.0 Age Group=ages 27 ==> Disease-Class=A sthma 27 conf:(1) 1665. Temporal Concept=years Organism Attribute=female Age Group=age 27 ==> Dis ease-Class=Asthma 27 conf:(1) 1666. Temporal Concept=prior to NUMERAL=2.0 Spatial Concept=within 27 ==> Disea se-Class=Asthma 27 conf:(1) 1667. Temporal Concept=prior to Research Activity=study Human=subject 27 ==> Di sease-Class=Asthma 27 conf:(1) 1668. Temporal Concept=prior to Therapeutic or Preventive Procedure=treatment S patial Concept=within 27 ==> Disease-Class=Asthma 27 conf:(1) 1669. Temporal Concept=months Qualitative Concept=last Spatial Concept=within 2 7 ==> Disease-Class=Asthma 27 conf:(1) 1670. Intellectual Product=pack years SYMBOL=> NUMERAL=10.0 27 ==> Disease-Clas s=Asthma 27 conf:(1) 1671. Clinical Attribute=parenteral Pharmacologic Substance=corticosteroids Bod y Space or Junction=oral 27 ==> Disease-Class=Asthma 27 conf:(1) 1672. Pharmacologic Substance=corticosteroids Laboratory Procedure=screening Bo dy Space or Junction=oral 27 ==> Disease-Class=Asthma 27 conf:(1) 1673. Pharmacologic Substance=salbutamol UNIT=% Diagnostic Procedure=fev1 27 == > Disease-Class=Asthma 27 conf:(1) 1674. Pharmacologic Substance=bronchodilator UNIT=% Qualitative Concept=pre 27 ==> Disease-Class=Asthma 27 conf:(1) 1675. Pharmacologic Substance=bronchodilator Qualitative Concept=pre Diagnostic Procedure=fev1 27 ==> Disease-Class=Asthma 27 conf:(1) 1676. SYMBOL=- Quantitative Concept=short Qualitative Concept=beta 27 ==> Disea se-Class=Asthma 27 conf:(1) 1677. SYMBOL=- Disease or Syndrome=asthma Sign or Symptom=run 27 ==> Disease-Cl ass=Asthma 27 conf:(1) 1678. SYMBOL=- Activity=inhaled Body Space or Junction=oral 27 ==> Disease-Clas s=Asthma 27 conf:(1) 1679. SYMBOL== UNIT=% Idea or Concept=predicted 27 ==> Disease-Class=Asthma 27 conf:(1) 1680. NUMERAL=1.0 Research Activity=study Spatial Concept=within 27 ==> Disease -Class=Asthma 27 conf:(1) 1681. Idea or Concept=predicted Qualitative Concept=normal Diagnostic Procedure =fev1 27 ==> Disease-Class=Asthma 27 conf:(1) 1682. Idea or Concept=predicted Disease or Syndrome=asthma Diagnostic Procedure =fev1 27 ==> Disease-Class=Asthma 27 conf:(1) 1683. Idea or Concept=opinion Professional or Occupational Group=investigator I ndividual Behavior=participation 27 ==> Disease-Class=Asthma 27 conf:(1) 1684. Research Activity=study Professional or Occupational Group=investigator A ctivity=put 27 ==> Disease-Class=Asthma 27 conf:(1) 1685. Qualitative Concept=has Spatial Concept=within Human=subject 27 ==> Disea se-Class=Asthma 27 conf:(1) 1686. Therapeutic or Preventive Procedure=treatment Disease or Syndrome=asthma Individual Behavior=visit 27 ==> Disease-Class=Asthma 27 conf:(1) 1687. Temporal Concept=years NUMERAL=18.0 Idea or Concept=eligible Age Group=ag es 27 ==> Disease-Class=Asthma 27 conf:(1) 1688. Temporal Concept=years NUMERAL=18.0 Research Activity=study Age Group=age s 27 ==> Disease-Class=Asthma 27 conf:(1) 1689. Temporal Concept=prior to NUMERAL=12.0 Spatial Concept=within Laboratory

Procedure=screening 27 ==> Disease-Class=Asthma 27 conf:(1) 1690. Pharmacologic Substance=corticosteroids NUMERAL=1.0 Spatial Concept=withi n Body Space or Junction=oral 27 ==> Disease-Class=Asthma 27 conf:(1) 1691. Temporal Concept=years NUMERAL=18.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 27 ==> Disease-Class=Asthma 27 conf:(1) 1692. Temporal Concept=past 26 ==> Disease-Class=Asthma 26 conf:(1) 1693. Temporal Concept=ed 26 ==> Disease-Class=Asthma 26 conf:(1) 1694. Pharmacologic Substance=symbicort 26 ==> Disease-Class=Asthma 26 conf: (1) 1695. NUMERAL=150.0 26 ==> Disease-Class=Asthma 26 conf:(1) 1696. Qualitative Concept=well 26 ==> Disease-Class=Asthma 26 conf:(1) 1697. Qualitative Concept=at risk 26 ==> Disease-Class=Asthma 26 conf:(1) 1698. Qualitative Concept=same 26 ==> Disease-Class=Asthma 26 conf:(1) 1699. Qualitative Concept=specific 26 ==> Disease-Class=Asthma 26 conf:(1) 1700. Functional Concept=include 26 ==> Disease-Class=Asthma 26 conf:(1) 1701. Biomedical Occupation or Discipline=or nursing 26 ==> Disease-Class=Asthm a 26 conf:(1) 1702. Natural Phenomenon or Process=ray 26 ==> Disease-Class=Asthma 26 conf: (1) 1703. Finding=sexually active 26 ==> Disease-Class=Asthma 26 conf:(1) 1704. Family Group=partner 26 ==> Disease-Class=Asthma 26 conf:(1) 1705. Patient or Disabled Group=patients NUMERAL=6.0 26 ==> Disease-Class=Asthm a 26 conf:(1) 1706. Patient or Disabled Group=patients Qualitative Concept=other 26 ==> Disea se-Class=Asthma 26 conf:(1) 1707. Health Care Activity=documented Diagnostic Procedure=fev1 26 ==> DiseaseClass=Asthma 26 conf:(1) 1708. Temporal Concept=prior to Functional Concept=requiring 26 ==> Disease-Cla ss=Asthma 26 conf:(1) 1709. Temporal Concept=months Pharmacologic Substance=corticosteroids 26 ==> Di sease-Class=Asthma 26 conf:(1) 1710. Temporal Concept=month Disease or Syndrome=asthma 26 ==> Disease-Class=As thma 26 conf:(1) 1711. Clinical Attribute=parenteral Spatial Concept=within 26 ==> Disease-Class =Asthma 26 conf:(1) 1712. Pharmacologic Substance=medications Functional Concept=use of 26 ==> Dise ase-Class=Asthma 26 conf:(1) 1713. Pharmacologic Substance=medication NO=not 26 ==> Disease-Class=Asthma 26 conf:(1) 1714. Pharmacologic Substance=corticosteroid Disease or Syndrome=asthma 26 ==> Disease-Class=Asthma 26 conf:(1) 1715. Pharmacologic Substance=drug Spatial Concept=within 26 ==> Disease-Class= Asthma 26 conf:(1) 1716. NO=not Organism Function=childbearing 26 ==> Disease-Class=Asthma 26 c onf:(1) 1717. SYMBOL=- Idea or Concept=eligible 26 ==> Disease-Class=Asthma 26 conf: (1) 1718. SYMBOL=- Qualitative Concept=inclusion 26 ==> Disease-Class=Asthma 26 conf:(1) 1719. SYMBOL=- Individual Behavior=visits 26 ==> Disease-Class=Asthma 26 con f:(1) 1720. SYMBOL=> NUMERAL=3.0 26 ==> Disease-Class=Asthma 26 conf:(1) 1721. SYMBOL=> Functional Concept=use of 26 ==> Disease-Class=Asthma 26 conf :(1) 1722. SYMBOL=>= Professional or Occupational Group=physician 26 ==> Disease-Cla ss=Asthma 26 conf:(1) 1723. NUMERAL=2.0 Sign or Symptom=symptoms 26 ==> Disease-Class=Asthma 26 co nf:(1) 1724. NUMERAL=3.0 Functional Concept=use of 26 ==> Disease-Class=Asthma 26 c onf:(1)

1725. NUMERAL=1.0 Qualitative Concept=has 26 ==> Disease-Class=Asthma 26 con f:(1) 1726. Quantitative Concept=pack Spatial Concept=within 26 ==> Disease-Class=Ast hma 26 conf:(1) 1727. Quantitative Concept=could Research Activity=study 26 ==> Disease-Class=A sthma 26 conf:(1) 1728. UNIT=% Research Activity=study 26 ==> Disease-Class=Asthma 26 conf:(1) 1729. UNIT=time Laboratory Procedure=screening 26 ==> Disease-Class=Asthma 26 conf:(1) 1730. Organism Attribute=female Laboratory Procedure=screening 26 ==> Disease-C lass=Asthma 26 conf:(1) 1731. Idea or Concept=eligible Human=subject 26 ==> Disease-Class=Asthma 26 conf:(1) 1732. Research Activity=study Population Group=women 26 ==> Disease-Class=Asthm a 26 conf:(1) 1733. Research Activity=study Organism Function=pregnancy 26 ==> Disease-Class= Asthma 26 conf:(1) 1734. Qualitative Concept=other Human=subject 26 ==> Disease-Class=Asthma 26 conf:(1) 1735. Qualitative Concept=beta Spatial Concept=within 26 ==> Disease-Class=Asth ma 26 conf:(1) 1736. Qualitative Concept=beta Disease or Syndrome=asthma 26 ==> Disease-Class= Asthma 26 conf:(1) 1737. Qualitative Concept=from Human=subjects 26 ==> Disease-Class=Asthma 26 conf:(1) 1738. Qualitative Concept=significant Laboratory Procedure=screening 26 ==> Dis ease-Class=Asthma 26 conf:(1) 1739. Therapeutic or Preventive Procedure=treatment Human=subjects 26 ==> Disea se-Class=Asthma 26 conf:(1) 1740. Therapeutic or Preventive Procedure=treatment Human=subject 26 ==> Diseas e-Class=Asthma 26 conf:(1) 1741. Functional Concept=including Spatial Concept=within 26 ==> Disease-Class= Asthma 26 conf:(1) 1742. Pathologic Function=hypoxic Disease or Syndrome=asthma 26 ==> Disease-Cla ss=Asthma 26 conf:(1) 1743. Disease or Syndrome=asthma Manufactured Object=controller 26 ==> DiseaseClass=Asthma 26 conf:(1) 1744. Disease or Syndrome=disease Professional or Occupational Group=investigat or 26 ==> Disease-Class=Asthma 26 conf:(1) 1745. Laboratory Procedure=screening Individual Behavior=visits 26 ==> DiseaseClass=Asthma 26 conf:(1) 1746. Patient or Disabled Group=patients Spatial Concept=within Individual Beha vior=visit 26 ==> Disease-Class=Asthma 26 conf:(1) 1747. Health Care Activity=documented UNIT=% Diagnostic Procedure=fev1 26 ==> D isease-Class=Asthma 26 conf:(1) 1748. Temporal Concept=years Quantitative Concept=pack Finding=smoking history 26 ==> Disease-Class=Asthma 26 conf:(1) 1749. Temporal Concept=history of SYMBOL=- Disease or Syndrome=asthma 26 ==> Di sease-Class=Asthma 26 conf:(1) 1750. Temporal Concept=prior to NUMERAL=30.0 Spatial Concept=within 26 ==> Dise ase-Class=Asthma 26 conf:(1) 1751. Temporal Concept=prior to Research Activity=study Functional Concept=star t 26 ==> Disease-Class=Asthma 26 conf:(1) 1752. Temporal Concept=during NO=not Research Activity=study 26 ==> Disease-Cla ss=Asthma 26 conf:(1) 1753. Temporal Concept=months NUMERAL=12.0 Disease or Syndrome=asthma 26 ==> Di sease-Class=Asthma 26 conf:(1) 1754. Temporal Concept=months Spatial Concept=within Individual Behavior=visit 26 ==> Disease-Class=Asthma 26 conf:(1) 1755. Temporal Concept=month NUMERAL=1.0 Spatial Concept=within 26 ==> Disease-

Class=Asthma 26 conf:(1) 1756. Temporal Concept=before Spatial Concept=within Individual Behavior=visit 26 ==> Disease-Class=Asthma 26 conf:(1) 1757. Clinical Attribute=parenteral Spatial Concept=within Body Space or Juncti on=oral 26 ==> Disease-Class=Asthma 26 conf:(1) 1758. NO=exclusion criteria SYMBOL=- Qualitative Concept=inclusion 26 ==> Disea se-Class=Asthma 26 conf:(1) 1759. SYMBOL=- Therapeutic or Preventive Procedure=treatment Disease or Syndrom e=asthma 26 ==> Disease-Class=Asthma 26 conf:(1) 1760. SYMBOL=- Therapeutic or Preventive Procedure=intubation Finding=life 26 = => Disease-Class=Asthma 26 conf:(1) 1761. NUMERAL=2.0 Spatial Concept=within Laboratory Procedure=screening 26 ==> Disease-Class=Asthma 26 conf:(1) 1762. NUMERAL=4.0 Spatial Concept=within Individual Behavior=visit 26 ==> Disea se-Class=Asthma 26 conf:(1) 1763. Quantitative Concept=short Idea or Concept=acting Individual Behavior=vis it 26 ==> Disease-Class=Asthma 26 conf:(1) 1764. Laboratory or Test Result=pc20 Diagnostic Procedure=fev1 Organic Chemical =methacholine 26 ==> Disease-Class=Asthma 26 conf:(1) 1765. Qualitative Concept=last Spatial Concept=within Disease or Syndrome=asthm a 26 ==> Disease-Class=Asthma 26 conf:(1) 1766. Spatial Concept=within Individual Behavior=visit Human=subject 26 ==> Dis ease-Class=Asthma 26 conf:(1) 1767. NO=not NUMERAL=1.0 Spatial Concept=within Individual Behavior=visit 26 == > Disease-Class=Asthma 26 conf:(1) 1768. SYMBOL=- Quantitative Concept=short Idea or Concept=acting Qualitative Co ncept=beta 26 ==> Disease-Class=Asthma 26 conf:(1) 1769. UNIT=% Idea or Concept=predicted Qualitative Concept=normal Diagnostic Pr ocedure=fev1 26 ==> Disease-Class=Asthma 26 conf:(1) 1770. UNIT=% Idea or Concept=predicted Disease or Syndrome=asthma Diagnostic Pr ocedure=fev1 26 ==> Disease-Class=Asthma 26 conf:(1) 1771. UNIT=m2 25 ==> Disease-Class=Asthma 25 conf:(1) 1772. Qualitative Concept=receiving 25 ==> Disease-Class=Asthma 25 conf:(1) 1773. Qualitative Concept=except 25 ==> Disease-Class=Asthma 25 conf:(1) 1774. Functional Concept=reversible 25 ==> Disease-Class=Asthma 25 conf:(1) 1775. Functional Concept=symptomatic 25 ==> Disease-Class=Asthma 25 conf:(1) 1776. Spatial Concept=site 25 ==> Disease-Class=Asthma 25 conf:(1) 1777. Organism Function=breastfeeding 25 ==> Disease-Class=Asthma 25 conf:(1 ) 1778. Organism Function=urine pregnancy test 25 ==> Disease-Class=Asthma 25 conf:(1) 1779. Finding=problems 25 ==> Disease-Class=Asthma 25 conf:(1) 1780. Professional or Occupational Group=health 25 ==> Disease-Class=Asthma 25 conf:(1) 1781. Sign or Symptom=inflammatory 25 ==> Disease-Class=Asthma 25 conf:(1) 1782. Activity=double 25 ==> Disease-Class=Asthma 25 conf:(1) 1783. Anatomical Abnormality=sinus 25 ==> Disease-Class=Asthma 25 conf:(1) 1784. Mental Process=practice 25 ==> Disease-Class=Asthma 25 conf:(1) 1785. Patient or Disabled Group=patients NUMERAL=3.0 25 ==> Disease-Class=Asthm a 25 conf:(1) 1786. Patient or Disabled Group=patients Idea or Concept=acting 25 ==> DiseaseClass=Asthma 25 conf:(1) 1787. Patient or Disabled Group=patients Therapeutic or Preventive Procedure=tr eated with 25 ==> Disease-Class=Asthma 25 conf:(1) 1788. Health Care Activity=diagnosis NUMERAL=1.0 25 ==> Disease-Class=Asthma 25 conf:(1) 1789. Health Care Activity=enrollment Disease or Syndrome=asthma 25 ==> Disease -Class=Asthma 25 conf:(1) 1790. Temporal Concept=years NUMERAL=15.0 25 ==> Disease-Class=Asthma 25 con f:(1)

1791. Temporal Concept=prior to Qualitative Concept=has 25 ==> Disease-Class=As thma 25 conf:(1) 1792. Temporal Concept=weeks Pharmacologic Substance=corticosteroids 25 ==> Dis ease-Class=Asthma 25 conf:(1) 1793. Temporal Concept=weeks Functional Concept=use of 25 ==> Disease-Class=Ast hma 25 conf:(1) 1794. Temporal Concept=year NUMERAL=10.0 25 ==> Disease-Class=Asthma 25 conf :(1) 1795. Temporal Concept=period Therapeutic or Preventive Procedure=treatment 25 ==> Disease-Class=Asthma 25 conf:(1) 1796. Intellectual Product=pack years Therapeutic or Preventive Procedure=ex 25 ==> Disease-Class=Asthma 25 conf:(1) 1797. Intellectual Product=pack years Behavior Problem=smokers 25 ==> Disease-C lass=Asthma 25 conf:(1) 1798. Intellectual Product=guidelines Social Behavior=according 25 ==> DiseaseClass=Asthma 25 conf:(1) 1799. Intellectual Product=method Contraception=contraception 25 ==> Disease-Cl ass=Asthma 25 conf:(1) 1800. Pharmacologic Substance=medications Human=subject 25 ==> Disease-Class=As thma 25 conf:(1) 1801. Pharmacologic Substance=drugs Research Activity=study 25 ==> Disease-Clas s=Asthma 25 conf:(1) 1802. Pharmacologic Substance=medication Quantitative Concept=dose 25 ==> Disea se-Class=Asthma 25 conf:(1) 1803. Pharmacologic Substance=salbutamol Individual Behavior=visit 25 ==> Disea se-Class=Asthma 25 conf:(1) 1804. NO=not Therapeutic or Preventive Procedure=treatment 25 ==> Disease-Class =Asthma 25 conf:(1) 1805. SYMBOL=- Research Activity=entry 25 ==> Disease-Class=Asthma 25 conf:( 1) 1806. SYMBOL=- Therapeutic or Preventive Procedure=procedures 25 ==> Disease-Cl ass=Asthma 25 conf:(1) 1807. SYMBOL=- Functional Concept=required 25 ==> Disease-Class=Asthma 25 co nf:(1) 1808. SYMBOL=- Functional Concept=systemic 25 ==> Disease-Class=Asthma 25 co nf:(1) 1809. SYMBOL=- Natural Phenomenon or Process=ray 25 ==> Disease-Class=Asthma 25 conf:(1) 1810. SYMBOL=- Capacity=ability 25 ==> Disease-Class=Asthma 25 conf:(1) 1811. SYMBOL=> Human=subject 25 ==> Disease-Class=Asthma 25 conf:(1) 1812. SYMBOL=< NUMERAL=3.0 25 ==> Disease-Class=Asthma 25 conf:(1) 1813. SYMBOL=< Organic Chemical=methacholine 25 ==> Disease-Class=Asthma 25 conf:(1) 1814. SYMBOL=<= Diagnostic Procedure=fev1 25 ==> Disease-Class=Asthma 25 con f:(1) 1815. NUMERAL=20.0 UNIT=% 25 ==> Disease-Class=Asthma 25 conf:(1) 1816. NUMERAL=2.0 Functional Concept=use of 25 ==> Disease-Class=Asthma 25 c onf:(1) 1817. NUMERAL=3.0 Therapeutic or Preventive Procedure=treatment 25 ==> DiseaseClass=Asthma 25 conf:(1) 1818. NUMERAL=14.0 Research Activity=study 25 ==> Disease-Class=Asthma 25 co nf:(1) 1819. NUMERAL=50.0 UNIT=% 25 ==> Disease-Class=Asthma 25 conf:(1) 1820. Quantitative Concept=kg UNIT=m2 25 ==> Disease-Class=Asthma 25 conf:(1 ) 1821. Quantitative Concept=first Individual Behavior=visit 25 ==> Disease-Class =Asthma 25 conf:(1) 1822. Organism Attribute=females Organism Function=pregnant 25 ==> Disease-Clas s=Asthma 25 conf:(1) 1823. Idea or Concept=predicted Qualitative Concept=pre 25 ==> Disease-Class=As

thma 25 conf:(1) 1824. Idea or Concept=acting Research Activity=study 25 ==> Disease-Class=Asthm a 25 conf:(1) 1825. Idea or Concept=acting Disease or Syndrome=ics 25 ==> Disease-Class=Asthm a 25 conf:(1) 1826. Research Activity=study Qualitative Concept=acceptable 25 ==> Disease-Cla ss=Asthma 25 conf:(1) 1827. Research Activity=study Family Group=parent 25 ==> Disease-Class=Asthma 2 5 conf:(1) 1828. Qualitative Concept=beta Functional Concept=use of 25 ==> Disease-Class=A sthma 25 conf:(1) 1829. Qualitative Concept=acceptable Contraception=contraception 25 ==> Disease -Class=Asthma 25 conf:(1) 1830. Therapeutic or Preventive Procedure=administration Spatial Concept=within 25 ==> Disease-Class=Asthma 25 conf:(1) 1831. Functional Concept=participate Professional or Occupational Group=investi gator 25 ==> Disease-Class=Asthma 25 conf:(1) 1832. Functional Concept=use Capacity=able to 25 ==> Disease-Class=Asthma 25 conf:(1) 1833. Functional Concept=systemic Activity=inhaled 25 ==> Disease-Class=Asthma 25 conf:(1) 1834. Spatial Concept=between Age Group=age 25 ==> Disease-Class=Asthma 25 c onf:(1) 1835. Spatial Concept=within Professional or Occupational Group=investigator 25 ==> Disease-Class=Asthma 25 conf:(1) 1836. Organism Function=inhalation Diagnostic Procedure=fev1 25 ==> Disease-Cla ss=Asthma 25 conf:(1) 1837. Professional or Occupational Group=investigator Individual Behavior=visit 25 ==> Disease-Class=Asthma 25 conf:(1) 1838. Family Group=parent Human=subject 25 ==> Disease-Class=Asthma 25 conf: (1) 1839. Individual Behavior=participation Human=subject 25 ==> Disease-Class=Asth ma 25 conf:(1) 1840. Health Care Activity=diagnosis SYMBOL=- Disease or Syndrome=asthma 25 ==> Disease-Class=Asthma 25 conf:(1) 1841. Health Care Activity=apply NO=exclusion criteria Qualitative Concept=incl usion 25 ==> Disease-Class=Asthma 25 conf:(1) 1842. Health Care Activity=apply SYMBOL=- Qualitative Concept=inclusion 25 ==> Disease-Class=Asthma 25 conf:(1) 1843. Temporal Concept=years SYMBOL=- Spatial Concept=within 25 ==> Disease-Cla ss=Asthma 25 conf:(1) 1844. Temporal Concept=prior to NUMERAL=4.0 Disease or Syndrome=asthma 25 ==> D isease-Class=Asthma 25 conf:(1) 1845. Temporal Concept=prior to NUMERAL=12.0 Individual Behavior=visit 25 ==> D isease-Class=Asthma 25 conf:(1) 1846. Temporal Concept=prior to Therapeutic or Preventive Procedure=treatment L aboratory Procedure=screening 25 ==> Disease-Class=Asthma 25 conf:(1) 1847. Temporal Concept=weeks Spatial Concept=within Activity=inhaled 25 ==> Dis ease-Class=Asthma 25 conf:(1) 1848. Temporal Concept=before Spatial Concept=within Laboratory Procedure=scree ning 25 ==> Disease-Class=Asthma 25 conf:(1) 1849. Pharmacologic Substance=agonist SYMBOL=- Qualitative Concept=beta 25 ==> Disease-Class=Asthma 25 conf:(1) 1850. Pharmacologic Substance=agonist SYMBOL=- Activity=inhaled 25 ==> DiseaseClass=Asthma 25 conf:(1) 1851. Pharmacologic Substance=agonist Quantitative Concept=short Idea or Concep t=acting 25 ==> Disease-Class=Asthma 25 conf:(1) 1852. NO=not Research Activity=study Individual Behavior=visit 25 ==> Disease-C lass=Asthma 25 conf:(1) 1853. SYMBOL=- NUMERAL=3.0 Disease or Syndrome=asthma 25 ==> Disease-Class=Asth

ma 25 conf:(1) 1854. SYMBOL=- Quantitative Concept=pack Spatial Concept=within 25 ==> DiseaseClass=Asthma 25 conf:(1) 1855. SYMBOL=- Quantitative Concept=short Disease or Syndrome=asthma 25 ==> Dis ease-Class=Asthma 25 conf:(1) 1856. SYMBOL=- Therapeutic or Preventive Procedure=intubation Disease or Syndro me=asthma 25 ==> Disease-Class=Asthma 25 conf:(1) 1857. SYMBOL=- Spatial Concept=within Finding=lives 25 ==> Disease-Class=Asthma 25 conf:(1) 1858. SYMBOL=< Quantitative Concept=ml Laboratory or Test Result=pc20 25 ==> Di sease-Class=Asthma 25 conf:(1) 1859. SYMBOL=>= Laboratory Procedure=screening Diagnostic Procedure=fev1 25 ==> Disease-Class=Asthma 25 conf:(1) 1860. SYMBOL=<= UNIT=% Diagnostic Procedure=fev1 25 ==> Disease-Class=Asthma 25 conf:(1) 1861. NUMERAL=1.0 Functional Concept=use of Individual Behavior=visit 25 ==> Di sease-Class=Asthma 25 conf:(1) 1862. NUMERAL=1.0 Individual Behavior=visit Human=subjects 25 ==> Disease-Class =Asthma 25 conf:(1) 1863. NUMERAL=12.0 Spatial Concept=within Individual Behavior=visit 25 ==> Dise ase-Class=Asthma 25 conf:(1) 1864. Quantitative Concept=exacerbation Spatial Concept=within Individual Behav ior=visit 25 ==> Disease-Class=Asthma 25 conf:(1) 1865. UNIT=% Idea or Concept=predicted Qualitative Concept=pre 25 ==> Disease-C lass=Asthma 25 conf:(1) 1866. UNIT=% Spatial Concept=within Laboratory Procedure=screening 25 ==> Disea se-Class=Asthma 25 conf:(1) 1867. Idea or Concept=opinion Professional or Occupational Group=investigator H uman=subject 25 ==> Disease-Class=Asthma 25 conf:(1) 1868. Disease or Syndrome=asthma Body Space or Junction=oral Individual Behavio r=visit 25 ==> Disease-Class=Asthma 25 conf:(1) 1869. Health Care Activity=apply NO=exclusion criteria SYMBOL=- Qualitative Con cept=inclusion 25 ==> Disease-Class=Asthma 25 conf:(1) 1870. Temporal Concept=years SYMBOL=- NUMERAL=10.0 Finding=smoking history 25 = => Disease-Class=Asthma 25 conf:(1) 1871. Temporal Concept=years SYMBOL=- Quantitative Concept=pack Finding=smoking history 25 ==> Disease-Class=Asthma 25 conf:(1) 1872. Temporal Concept=prior to NUMERAL=12.0 Laboratory Procedure=screening Ind ividual Behavior=visit 25 ==> Disease-Class=Asthma 25 conf:(1) 1873. Pharmacologic Substance=corticosteroids NUMERAL=1.0 Spatial Concept=withi n Individual Behavior=visit 25 ==> Disease-Class=Asthma 25 conf:(1) 1874. Pharmacologic Substance=corticosteroids NUMERAL=1.0 Body Space or Junctio n=oral Individual Behavior=visit 25 ==> Disease-Class=Asthma 25 conf:(1) 1875. Pharmacologic Substance=bronchodilator UNIT=% Qualitative Concept=pre Dia gnostic Procedure=fev1 25 ==> Disease-Class=Asthma 25 conf:(1) 1876. SYMBOL=>= UNIT=% Laboratory Procedure=screening Diagnostic Procedure=fev1 25 ==> Disease-Class=Asthma 25 conf:(1) 1877. Intellectual Product=level 24 ==> Disease-Class=Asthma 24 conf:(1) 1878. Intellectual Product=pack year 24 ==> Disease-Class=Asthma 24 conf:(1) 1879. NUMERAL=400.0 24 ==> Disease-Class=Asthma 24 conf:(1) 1880. Quantitative Concept=greater 24 ==> Disease-Class=Asthma 24 conf:(1) 1881. Idea or Concept=continuous 24 ==> Disease-Class=Asthma 24 conf:(1) 1882. Population Group=individuals 24 ==> Disease-Class=Asthma 24 conf:(1) 1883. Population Group=legal guardian 24 ==> Disease-Class=Asthma 24 conf:(1 ) 1884. Population Group=race 24 ==> Disease-Class=Asthma 24 conf:(1) 1885. Therapeutic or Preventive Procedure=treatments 24 ==> Disease-Class=Asthm a 24 conf:(1) 1886. Functional Concept=included 24 ==> Disease-Class=Asthma 24 conf:(1) 1887. Disease or Syndrome=respiratory infection 24 ==> Disease-Class=Asthma 24

conf:(1) 1888. Body Substance=urine 24 ==> Disease-Class=Asthma 24 conf:(1) 1889. Regulation or Law=questionnaire 24 ==> Disease-Class=Asthma 24 )

conf:(1

1890. Sign or Symptom=symptom 24 ==> Disease-Class=Asthma 24 conf:(1) 1891. Diagnostic Procedure=skin test 24 ==> Disease-Class=Asthma 24 conf:(1) 1892. Diagnostic Procedure=skin prick test 24 ==> Disease-Class=Asthma 24 co nf:(1) 1893. Individual Behavior=conduct 24 ==> Disease-Class=Asthma 24 conf:(1) 1894. Willing=willingness 24 ==> Disease-Class=Asthma 24 conf:(1) 1895. Patient or Disabled Group=patients Health Care Activity=diagnosis 24 ==> Disease-Class=Asthma 24 conf:(1) 1896. Patient or Disabled Group=patients Therapeutic or Preventive Procedure=th erapy 24 ==> Disease-Class=Asthma 24 conf:(1) 1897. Temporal Concept=years NUMERAL=14.0 24 ==> Disease-Class=Asthma 24 con f:(1) 1898. Temporal Concept=current SYMBOL=- 24 ==> Disease-Class=Asthma 24 conf: (1) 1899. Temporal Concept=current Functional Concept=use of 24 ==> Disease-Class=A sthma 24 conf:(1) 1900. Temporal Concept=history of Behavior Problem=alcohol abuse 24 ==> Disease -Class=Asthma 24 conf:(1) 1901. Temporal Concept=prior to Disease or Syndrome=lower respiratory tract inf ection 24 ==> Disease-Class=Asthma 24 conf:(1) 1902. Temporal Concept=weeks Therapeutic or Preventive Procedure=treatment 24 = => Disease-Class=Asthma 24 conf:(1) 1903. Temporal Concept=period Individual Behavior=visit 24 ==> Disease-Class=As thma 24 conf:(1) 1904. Temporal Concept=day SYMBOL=> 24 ==> Disease-Class=Asthma 24 conf:(1) 1905. Temporal Concept=day Laboratory Procedure=screening 24 ==> Disease-Class= Asthma 24 conf:(1) 1906. Temporal Concept=before SYMBOL=>= 24 ==> Disease-Class=Asthma 24 conf: (1) 1907. Temporal Concept=currently SYMBOL=- 24 ==> Disease-Class=Asthma 24 con f:(1) 1908. Temporal Concept=course Research Activity=study 24 ==> Disease-Class=Asth ma 24 conf:(1) 1909. Intellectual Product=method Qualitative Concept=acceptable 24 ==> Disease -Class=Asthma 24 conf:(1) 1910. Intellectual Product=method Willing=agree 24 ==> Disease-Class=Asthma 24 conf:(1) 1911. Pharmacologic Substance=steroids Functional Concept=systemic 24 ==> Disea se-Class=Asthma 24 conf:(1) 1912. Pharmacologic Substance=pef Diagnostic Procedure=fev1 24 ==> Disease-Clas s=Asthma 24 conf:(1) 1913. Pharmacologic Substance=corticosteroids NUMERAL=3.0 24 ==> Disease-Class= Asthma 24 conf:(1) 1914. Pharmacologic Substance=salbutamol SYMBOL=- 24 ==> Disease-Class=Asthma 2 4 conf:(1) 1915. Pharmacologic Substance=spermicide Contraception=condom 24 ==> Disease-Cl ass=Asthma 24 conf:(1) 1916. SYMBOL=- Qualitative Concept=associated with 24 ==> Disease-Class=Asthma 24 conf:(1) 1917. SYMBOL=- Functional Concept=inclusive 24 ==> Disease-Class=Asthma 24 c onf:(1) 1918. SYMBOL=- Pathologic Function=hypoxic 24 ==> Disease-Class=Asthma 24 co nf:(1) 1919. SYMBOL=> Finding=smoking history 24 ==> Disease-Class=Asthma 24 conf:( 1) 1920. SYMBOL=> Activity=inhaled 24 ==> Disease-Class=Asthma 24 conf:(1)

1921. SYMBOL=< NUMERAL=10.0 24 ==> Disease-Class=Asthma 24 conf:(1) 1922. NUMERAL=2.0 Qualitative Concept=beta 24 ==> Disease-Class=Asthma 24 co nf:(1) 1923. NUMERAL=12.0 Body Space or Junction=oral 24 ==> Disease-Class=Asthma 24 conf:(1) 1924. Quantitative Concept=one Research Activity=study 24 ==> Disease-Class=Ast hma 24 conf:(1) 1925. Quantitative Concept=exacerbation Qualitative Concept=last 24 ==> Disease -Class=Asthma 24 conf:(1) 1926. Quantitative Concept=exacerbation Therapeutic or Preventive Procedure=tre atment 24 ==> Disease-Class=Asthma 24 conf:(1) 1927. Quantitative Concept=baseline Human=subject 24 ==> Disease-Class=Asthma 2 4 conf:(1) 1928. Quantitative Concept=pack Behavior Problem=smoking 24 ==> Disease-Class=A sthma 24 conf:(1) 1929. Quantitative Concept=product Qualitative Concept=investigational 24 ==> D isease-Class=Asthma 24 conf:(1) 1930. UNIT=% Idea or Concept=acting 24 ==> Disease-Class=Asthma 24 conf:(1) 1931. UNIT=% Therapeutic or Preventive Procedure=treatment 24 ==> Disease-Class =Asthma 24 conf:(1) 1932. Idea or Concept=continue Willing=agree 24 ==> Disease-Class=Asthma 24 conf:(1) 1933. Research Activity=study Qualitative Concept=completion 24 ==> Disease-Cla ss=Asthma 24 conf:(1) 1934. Research Activity=study Qualitative Concept=last 24 ==> Disease-Class=Ast hma 24 conf:(1) 1935. Research Activity=study Functional Concept=participating 24 ==> Disease-C lass=Asthma 24 conf:(1) 1936. Research Activity=study Pathologic Function=sterile 24 ==> Disease-Class= Asthma 24 conf:(1) 1937. Research Activity=study Age Group=child 24 ==> Disease-Class=Asthma 24 conf:(1) 1938. Qualitative Concept=negative Body Substance=serum 24 ==> Disease-Class=As thma 24 conf:(1) 1939. Qualitative Concept=last Functional Concept=use of 24 ==> Disease-Class=A sthma 24 conf:(1) 1940. Qualitative Concept=stable Activity=inhaled 24 ==> Disease-Class=Asthma 2 4 conf:(1) 1941. Qualitative Concept=potential Organism Function=childbearing 24 ==> Disea se-Class=Asthma 24 conf:(1) 1942. Therapeutic or Preventive Procedure=treatment Functional Concept=systemic 24 ==> Disease-Class=Asthma 24 conf:(1) 1943. Therapeutic or Preventive Procedure=anti Spatial Concept=within 24 ==> Di sease-Class=Asthma 24 conf:(1) 1944. Functional Concept=give Willing=willing 24 ==> Disease-Class=Asthma 24 conf:(1) 1945. Functional Concept=using Organism Function=childbearing 24 ==> Disease-Cl ass=Asthma 24 conf:(1) 1946. Spatial Concept=between Age Group=ages 24 ==> Disease-Class=Asthma 24 conf:(1) 1947. Spatial Concept=within Finding=life 24 ==> Disease-Class=Asthma 24 con f:(1) 1948. Organism Function=pregnancy test Body Substance=serum 24 ==> Disease-Clas s=Asthma 24 conf:(1) 1949. Organism Function=childbearing Contraception=birth control 24 ==> Disease -Class=Asthma 24 conf:(1) 1950. Pathologic Function=hypoxic Finding=life 24 ==> Disease-Class=Asthma 24 conf:(1) 1951. Natural Phenomenon or Process=ray Body Location or Region=chest 24 ==> Di sease-Class=Asthma 24 conf:(1)

1952. Regulation or Law=informed consent Sign or Symptom=signed 24 ==> DiseaseClass=Asthma 24 conf:(1) 1953. Health Care Activity=diagnosis Temporal Concept=months SYMBOL=>= 24 ==> D isease-Class=Asthma 24 conf:(1) 1954. Temporal Concept=history of Pharmacologic Substance=drug Behavior Problem =alcohol abuse 24 ==> Disease-Class=Asthma 24 conf:(1) 1955. Temporal Concept=prior to SYMBOL=>= Qualitative Concept=stable 24 ==> Dis ease-Class=Asthma 24 conf:(1) 1956. Temporal Concept=prior to NUMERAL=2.0 Individual Behavior=visit 24 ==> Di sease-Class=Asthma 24 conf:(1) 1957. Temporal Concept=prior to Research Activity=study Individual Behavior=vis it 24 ==> Disease-Class=Asthma 24 conf:(1) 1958. Temporal Concept=prior to Laboratory Procedure=screening Human=subject 24 ==> Disease-Class=Asthma 24 conf:(1) 1959. Pharmacologic Substance=agonists SYMBOL=- Activity=inhaled 24 ==> Disease -Class=Asthma 24 conf:(1) 1960. Pharmacologic Substance=agonist SYMBOL=- Quantitative Concept=short 24 == > Disease-Class=Asthma 24 conf:(1) 1961. Pharmacologic Substance=agonist Idea or Concept=acting Qualitative Concep t=beta 24 ==> Disease-Class=Asthma 24 conf:(1) 1962. Pharmacologic Substance=corticosteroids Spatial Concept=within Laboratory Procedure=screening 24 ==> Disease-Class=Asthma 24 conf:(1) 1963. Pharmacologic Substance=corticosteroids Activity=inhaled Body Space or Ju nction=oral 24 ==> Disease-Class=Asthma 24 conf:(1) 1964. NO=not SYMBOL=- Disease or Syndrome=asthma 24 ==> Disease-Class=Asthma 24 conf:(1) 1965. NO=not Spatial Concept=within Human=subject 24 ==> Disease-Class=Asthma 2 4 conf:(1) 1966. SYMBOL=- NUMERAL=10.0 Spatial Concept=within 24 ==> Disease-Class=Asthma 24 conf:(1) 1967. SYMBOL=- NUMERAL=2.0 Idea or Concept=acting 24 ==> Disease-Class=Asthma 2 4 conf:(1) 1968. SYMBOL=- Therapeutic or Preventive Procedure=anti Spatial Concept=within 24 ==> Disease-Class=Asthma 24 conf:(1) 1969. SYMBOL=- Pathologic Function=hypoxic Disease or Syndrome=asthma 24 ==> Di sease-Class=Asthma 24 conf:(1) 1970. SYMBOL=- Pathologic Function=hypoxic Finding=life 24 ==> Disease-Class=As thma 24 conf:(1) 1971. SYMBOL=- Laboratory Procedure=screening Diagnostic Procedure=fev1 24 ==> Disease-Class=Asthma 24 conf:(1) 1972. SYMBOL=>= NUMERAL=1.0 Disease or Syndrome=asthma 24 ==> Disease-Class=Ast hma 24 conf:(1) 1973. SYMBOL== Idea or Concept=predicted Diagnostic Procedure=fev1 24 ==> Disea se-Class=Asthma 24 conf:(1) 1974. NUMERAL=2.0 Spatial Concept=within Individual Behavior=visit 24 ==> Disea se-Class=Asthma 24 conf:(1) 1975. NUMERAL=2.0 Laboratory Procedure=screening Individual Behavior=visit 24 = => Disease-Class=Asthma 24 conf:(1) 1976. NUMERAL=1.0 UNIT=% Diagnostic Procedure=fev1 24 ==> Disease-Class=Asthma 24 conf:(1) 1977. NUMERAL=1.0 Activity=inhaled Individual Behavior=visit 24 ==> Disease-Cla ss=Asthma 24 conf:(1) 1978. Quantitative Concept=baseline Laboratory Procedure=screening Individual B ehavior=visit 24 ==> Disease-Class=Asthma 24 conf:(1) 1979. Quantitative Concept=value Idea or Concept=predicted Diagnostic Procedure =fev1 24 ==> Disease-Class=Asthma 24 conf:(1) 1980. UNIT=% Organism Function=inhalation Diagnostic Procedure=fev1 24 ==> Dise ase-Class=Asthma 24 conf:(1) 1981. UNIT=% Diagnostic Procedure=fev1 Human=subject 24 ==> Disease-Class=Asthm a 24 conf:(1)

1982. Idea or Concept=predicted Qualitative Concept=pre Diagnostic Procedure=fe v1 24 ==> Disease-Class=Asthma 24 conf:(1) 1983. Idea or Concept=acting Disease or Syndrome=asthma Activity=inhaled 24 ==> Disease-Class=Asthma 24 conf:(1) 1984. Therapeutic or Preventive Procedure=treatment Spatial Concept=within Dise ase or Syndrome=asthma 24 ==> Disease-Class=Asthma 24 conf:(1) 1985. Therapeutic or Preventive Procedure=treatment Disease or Syndrome=asthma Body Space or Junction=oral 24 ==> Disease-Class=Asthma 24 conf:(1) 1986. Therapeutic or Preventive Procedure=intubation Disease or Syndrome=asthma Finding=life 24 ==> Disease-Class=Asthma 24 conf:(1) 1987. Pathologic Function=hypoxic Disease or Syndrome=asthma Finding=life 24 == > Disease-Class=Asthma 24 conf:(1) 1988. Temporal Concept=prior to SYMBOL=- Laboratory Procedure=screening Individ ual Behavior=visit 24 ==> Disease-Class=Asthma 24 conf:(1) 1989. SYMBOL=- Pathologic Function=hypoxic Disease or Syndrome=asthma Finding=l ife 24 ==> Disease-Class=Asthma 24 conf:(1) 1990. SYMBOL== UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 24 == > Disease-Class=Asthma 24 conf:(1) 1991. NUMERAL=12.0 Spatial Concept=within Laboratory Procedure=screening Indivi dual Behavior=visit 24 ==> Disease-Class=Asthma 24 conf:(1) 1992. UNIT=% Idea or Concept=predicted Qualitative Concept=pre Diagnostic Proce dure=fev1 24 ==> Disease-Class=Asthma 24 conf:(1) 1993. Idea or Concept=opinion Research Activity=study Professional or Occupatio nal Group=investigator Individual Behavior=participation 24 ==> Disease-Class=As thma 24 conf:(1) 1994. Health Care Activity=type 23 ==> Disease-Class=Asthma 23 conf:(1) 1995. Temporal Concept=immediate 23 ==> Disease-Class=Asthma 23 conf:(1) 1996. Pharmacologic Substance=agent 23 ==> Disease-Class=Asthma 23 conf:(1) 1997. Qualitative Concept=moderate to severe 23 ==> Disease-Class=Asthma 23 conf:(1) 1998. Functional Concept=serious 23 ==> Disease-Class=Asthma 23 conf:(1) 1999. Functional Concept=basis 23 ==> Disease-Class=Asthma 23 conf:(1) 2000. Functional Concept=is a 23 ==> Disease-Class=Asthma 23 conf:(1) 2001. Functional Concept=includes 23 ==> Disease-Class=Asthma 23 conf:(1) 2002. Spatial Concept=gastrointestinal 23 ==> Disease-Class=Asthma 23 conf:( 1) 2003. Organ or Tissue Function=fev 23 ==> Disease-Class=Asthma 23 conf:(1) 2004. Body Location or Region=lower 23 ==> Disease-Class=Asthma 23 conf:(1) 2005. Sign or Symptom=medical condition 23 ==> Disease-Class=Asthma 23 conf: (1) 2006. Body System=endocrine 23 ==> Disease-Class=Asthma 23 conf:(1) 2007. Hazardous or Poisonous Substance=tobacco products 23 ==> Disease-Class=As thma 23 conf:(1) 2008. Allergy=allergies 23 ==> Disease-Class=Asthma 23 conf:(1) 2009. Patient or Disabled Group=patients Temporal Concept=history of 23 ==> Dis ease-Class=Asthma 23 conf:(1) 2010. Patient or Disabled Group=patients Research Activity=trial 23 ==> Disease -Class=Asthma 23 conf:(1) 2011. Patient or Disabled Group=patients Body Space or Junction=oral 23 ==> Dis ease-Class=Asthma 23 conf:(1) 2012. Patient or Disabled Group=patient Laboratory Procedure=screening 23 ==> D isease-Class=Asthma 23 conf:(1) 2013. Health Care Activity=documented Temporal Concept=history of 23 ==> Diseas e-Class=Asthma 23 conf:(1) 2014. Health Care Activity=documented Temporal Concept=prior to 23 ==> DiseaseClass=Asthma 23 conf:(1) 2015. Health Care Activity=documented Temporal Concept=months 23 ==> Disease-Cl ass=Asthma 23 conf:(1) 2016. Health Care Activity=enrolled Research Activity=study 23 ==> Disease-Clas s=Asthma 23 conf:(1)

2017. Temporal Concept=history of Finding=life 23 ==> Disease-Class=Asthma 23 conf:(1) 2018. Temporal Concept=after Research Activity=study 23 ==> Disease-Class=Asthm a 23 conf:(1) 2019. Temporal Concept=weeks Research Activity=study 23 ==> Disease-Class=Asthm a 23 conf:(1) 2020. Temporal Concept=months Functional Concept=use of 23 ==> Disease-Class=As thma 23 conf:(1) 2021. Temporal Concept=day Spatial Concept=within 23 ==> Disease-Class=Asthma 2 3 conf:(1) 2022. Temporal Concept=concomitant Functional Concept=use of 23 ==> Disease-Cla ss=Asthma 23 conf:(1) 2023. Intellectual Product=methods Contraception=contraception 23 ==> Disease-C lass=Asthma 23 conf:(1) 2024. Intellectual Product=until Research Activity=study 23 ==> Disease-Class=A sthma 23 conf:(1) 2025. Clinical Attribute=inability Research Activity=study 23 ==> Disease-Class =Asthma 23 conf:(1) 2026. Pharmacologic Substance=medications SYMBOL=- 23 ==> Disease-Class=Asthma 23 conf:(1) 2027. Pharmacologic Substance=medication Qualitative Concept=from 23 ==> Diseas e-Class=Asthma 23 conf:(1) 2028. Pharmacologic Substance=investigational drug NUMERAL=30.0 23 ==> DiseaseClass=Asthma 23 conf:(1) 2029. NO=no Laboratory Procedure=screening 23 ==> Disease-Class=Asthma 23 co nf:(1) 2030. NO=not Contraception=contraception 23 ==> Disease-Class=Asthma 23 conf :(1) 2031. SYMBOL=- NUMERAL=7.0 23 ==> Disease-Class=Asthma 23 conf:(1) 2032. SYMBOL=- NUMERAL=70.0 23 ==> Disease-Class=Asthma 23 conf:(1) 2033. SYMBOL=- NUMERAL=80.0 23 ==> Disease-Class=Asthma 23 conf:(1) 2034. SYMBOL=- Quantitative Concept=baseline 23 ==> Disease-Class=Asthma 23 conf:(1) 2035. SYMBOL=- Research Activity=trial 23 ==> Disease-Class=Asthma 23 conf:( 1) 2036. SYMBOL=- Organism Function=inhalation 23 ==> Disease-Class=Asthma 23 c onf:(1) 2037. SYMBOL=- Behavior Problem=smoker 23 ==> Disease-Class=Asthma 23 conf:( 1) 2038. NUMERAL=10.0 Functional Concept=non 23 ==> Disease-Class=Asthma 23 con f:(1) 2039. NUMERAL=5.0 Disease or Syndrome=asthma 23 ==> Disease-Class=Asthma 23 conf:(1) 2040. NUMERAL=6.0 Idea or Concept=acting 23 ==> Disease-Class=Asthma 23 conf :(1) 2041. NUMERAL=6.0 Qualitative Concept=last 23 ==> Disease-Class=Asthma 23 co nf:(1) 2042. NUMERAL=2.0 Human=subject 23 ==> Disease-Class=Asthma 23 conf:(1) 2043. Quantitative Concept=ml Spatial Concept=within 23 ==> Disease-Class=Asthm a 23 conf:(1) 2044. Quantitative Concept=dose Qualitative Concept=stable 23 ==> Disease-Class =Asthma 23 conf:(1) 2045. Organism Attribute=female Spatial Concept=between 23 ==> Disease-Class=As thma 23 conf:(1) 2046. Idea or Concept=acting Qualitative Concept=beta2 23 ==> Disease-Class=Ast hma 23 conf:(1) 2047. Idea or Concept=acting Functional Concept=use 23 ==> Disease-Class=Asthma 23 conf:(1) 2048. Idea or Concept=acting Body Space or Junction=oral 23 ==> Disease-Class=A sthma 23 conf:(1)

2049. Idea or Concept=opinion Activity=interfere 23 ==> Disease-Class=Asthma 23 conf:(1) 2050. Idea or Concept=opinion Activity=put 23 ==> Disease-Class=Asthma 23 co nf:(1) 2051. Idea or Concept=opinion Human-caused Phenomenon or Process=safety 23 ==> Disease-Class=Asthma 23 conf:(1) 2052. Research Activity=study Sign or Symptom=condition 23 ==> Disease-Class=As thma 23 conf:(1) 2053. Qualitative Concept=inclusion criteria Disease or Syndrome=asthma 23 ==> Disease-Class=Asthma 23 conf:(1) 2054. Qualitative Concept=related Disease or Syndrome=asthma 23 ==> Disease-Cla ss=Asthma 23 conf:(1) 2055. Qualitative Concept=from Individual Behavior=visit 23 ==> Disease-Class=A sthma 23 conf:(1) 2056. Qualitative Concept=last Activity=inhaled 23 ==> Disease-Class=Asthma 23 conf:(1) 2057. Qualitative Concept=acceptable Professional or Occupational Group=investi gator 23 ==> Disease-Class=Asthma 23 conf:(1) 2058. Functional Concept=use Laboratory Procedure=screening 23 ==> Disease-Clas s=Asthma 23 conf:(1) 2059. Functional Concept=using Contraception=birth control 23 ==> Disease-Class =Asthma 23 conf:(1) 2060. Disease or Syndrome=asthma Health Care Related Organization=hospital 23 = => Disease-Class=Asthma 23 conf:(1) 2061. Laboratory Procedure=screening MARK=& 23 ==> Disease-Class=Asthma 23 c onf:(1) 2062. Activity=put Individual Behavior=participation 23 ==> Disease-Class=Asthm a 23 conf:(1) 2063. Individual Behavior=visits Human=subject 23 ==> Disease-Class=Asthma 23 conf:(1) 2064. Temporal Concept=prior to Pharmacologic Substance=corticosteroids Body Sp ace or Junction=oral 23 ==> Disease-Class=Asthma 23 conf:(1) 2065. Temporal Concept=prior to SYMBOL=- Research Activity=study 23 ==> Disease -Class=Asthma 23 conf:(1) 2066. Temporal Concept=prior to NUMERAL=6.0 Laboratory Procedure=screening 23 = => Disease-Class=Asthma 23 conf:(1) 2067. Temporal Concept=prior to Body Space or Junction=oral Individual Behavior =visit 23 ==> Disease-Class=Asthma 23 conf:(1) 2068. Temporal Concept=during Research Activity=study Human=subject 23 ==> Dise ase-Class=Asthma 23 conf:(1) 2069. Temporal Concept=months NUMERAL=3.0 Body Space or Junction=oral 23 ==> Di sease-Class=Asthma 23 conf:(1) 2070. Temporal Concept=months Spatial Concept=within Body Space or Junction=ora l 23 ==> Disease-Class=Asthma 23 conf:(1) 2071. Temporal Concept=period SYMBOL=- Disease or Syndrome=asthma 23 ==> Diseas e-Class=Asthma 23 conf:(1) 2072. Intellectual Product=guidelines Research Activity=gina Disease or Syndrom e=asthma 23 ==> Disease-Class=Asthma 23 conf:(1) 2073. Pharmacologic Substance=agonists SYMBOL=- Qualitative Concept=beta 23 ==> Disease-Class=Asthma 23 conf:(1) 2074. Pharmacologic Substance=medication Quantitative Concept=dose Research Act ivity=study 23 ==> Disease-Class=Asthma 23 conf:(1) 2075. NO=not NUMERAL=1.0 Human=subject 23 ==> Disease-Class=Asthma 23 conf:( 1) 2076. SYMBOL=- NUMERAL=1.0 Laboratory Procedure=screening 23 ==> Disease-Class= Asthma 23 conf:(1) 2077. SYMBOL=- Quantitative Concept=short Individual Behavior=visit 23 ==> Dise ase-Class=Asthma 23 conf:(1) 2078. SYMBOL=- UNIT=% Functional Concept=increase 23 ==> Disease-Class=Asthma 2 3 conf:(1)

2079. SYMBOL=- Idea or Concept=acting Therapeutic or Preventive Procedure=treat ment 23 ==> Disease-Class=Asthma 23 conf:(1) 2080. SYMBOL=- Spatial Concept=within Finding=life 23 ==> Disease-Class=Asthma 23 conf:(1) 2081. SYMBOL=- Natural Phenomenon or Process=ray Body Location or Region=chest 23 ==> Disease-Class=Asthma 23 conf:(1) 2082. SYMBOL=- Professional or Occupational Group=physician Diagnostic Procedur e=diagnosed 23 ==> Disease-Class=Asthma 23 conf:(1) 2083. SYMBOL=> Laboratory Procedure=screening Individual Behavior=visit 23 ==> Disease-Class=Asthma 23 conf:(1) 2084. SYMBOL=>= UNIT=% Spatial Concept=within 23 ==> Disease-Class=Asthma 23 conf:(1) 2085. SYMBOL=>= Disease or Syndrome=asthma Professional or Occupational Group=p hysician 23 ==> Disease-Class=Asthma 23 conf:(1) 2086. SYMBOL=>= Laboratory Procedure=screening Activity=inhaled 23 ==> DiseaseClass=Asthma 23 conf:(1) 2087. NUMERAL=3.0 Spatial Concept=within Laboratory Procedure=screening 23 ==> Disease-Class=Asthma 23 conf:(1) 2088. NUMERAL=1.0 Disease or Syndrome=asthma Laboratory Procedure=screening 23 ==> Disease-Class=Asthma 23 conf:(1) 2089. Laboratory or Test Result=pc20 UNIT=% Diagnostic Procedure=fev1 23 ==> Di sease-Class=Asthma 23 conf:(1) 2090. Laboratory or Test Result=pc20 UNIT=% Organic Chemical=methacholine 23 == > Disease-Class=Asthma 23 conf:(1) 2091. UNIT=% Diagnostic Procedure=fev1 Activity=inhaled 23 ==> Disease-Class=As thma 23 conf:(1) 2092. Idea or Concept=opinion Professional or Occupational Group=investigator A ctivity=put 23 ==> Disease-Class=Asthma 23 conf:(1) 2093. Research Activity=study Activity=interfere Human=subject 23 ==> Disease-C lass=Asthma 23 conf:(1) 2094. Research Activity=study Individual Behavior=participation Human=subject 2 3 ==> Disease-Class=Asthma 23 conf:(1) 2095. Research Activity=study Human=subject Human-caused Phenomenon or Process= safety 23 ==> Disease-Class=Asthma 23 conf:(1) 2096. Therapeutic or Preventive Procedure=treatment Disease or Syndrome=asthma Laboratory Procedure=screening 23 ==> Disease-Class=Asthma 23 conf:(1) 2097. Spatial Concept=within Disease or Syndrome=asthma Body Space or Junction= oral 23 ==> Disease-Class=Asthma 23 conf:(1) 2098. Disease or Syndrome=asthma Laboratory Procedure=screening Body Space or J unction=oral 23 ==> Disease-Class=Asthma 23 conf:(1) 2099. Temporal Concept=years NUMERAL=10.0 Quantitative Concept=pack Finding=smo king history 23 ==> Disease-Class=Asthma 23 conf:(1) 2100. Temporal Concept=prior to NUMERAL=1.0 Spatial Concept=within Disease or S yndrome=asthma 23 ==> Disease-Class=Asthma 23 conf:(1) 2101. SYMBOL=- Quantitative Concept=short Idea or Concept=acting Disease or Syn drome=asthma 23 ==> Disease-Class=Asthma 23 conf:(1) 2102. SYMBOL=- Therapeutic or Preventive Procedure=intubation Disease or Syndro me=asthma Finding=life 23 ==> Disease-Class=Asthma 23 conf:(1) 2103. Health Care Activity=prescription 22 ==> Disease-Class=Asthma 22 conf: (1) 2104. NUMERAL=1.5 22 ==> Disease-Class=Asthma 22 conf:(1) 2105. Qualitative Concept=episodic 22 ==> Disease-Class=Asthma 22 conf:(1) 2106. Qualitative Concept=plus 22 ==> Disease-Class=Asthma 22 conf:(1) 2107. Qualitative Concept=when 22 ==> Disease-Class=Asthma 22 conf:(1) 2108. Disease or Syndrome=abnormalities 22 ==> Disease-Class=Asthma 22 conf: (1) 2109. Laboratory Procedure=tests 22 ==> Disease-Class=Asthma 22 conf:(1) 2110. Finding=adhere 22 ==> Disease-Class=Asthma 22 conf:(1) 2111. Finding=fall 22 ==> Disease-Class=Asthma 22 conf:(1) 2112. Health Care Related Organization=nhlbi 22 ==> Disease-Class=Asthma 22

conf:(1) 2113. Physiologic Function=airflow 22 ==> Disease-Class=Asthma 22 conf:(1) 2114. Patient or Disabled Group=patients Intellectual Product=guidelines 22 ==> Disease-Class=Asthma 22 conf:(1) 2115. Patient or Disabled Group=patients Qualitative Concept=last 22 ==> Diseas e-Class=Asthma 22 conf:(1) 2116. Patient or Disabled Group=patient Idea or Concept=opinion 22 ==> DiseaseClass=Asthma 22 conf:(1) 2117. Health Care Activity=feeding Organism Function=pregnant 22 ==> Disease-Cl ass=Asthma 22 conf:(1) 2118. Health Care Activity=hospitalization Temporal Concept=prior to 22 ==> Dis ease-Class=Asthma 22 conf:(1) 2119. Health Care Activity=documented NUMERAL=1.0 22 ==> Disease-Class=Asthma 2 2 conf:(1) 2120. Temporal Concept=years NUMERAL=6.0 22 ==> Disease-Class=Asthma 22 conf :(1) 2121. Temporal Concept=years NUMERAL=80.0 22 ==> Disease-Class=Asthma 22 con f:(1) 2122. Temporal Concept=current Therapeutic or Preventive Procedure=treatment 22 ==> Disease-Class=Asthma 22 conf:(1) 2123. Temporal Concept=prior to NUMERAL=5.0 22 ==> Disease-Class=Asthma 22 c onf:(1) 2124. Temporal Concept=months UNIT=% 22 ==> Disease-Class=Asthma 22 conf:(1) 2125. Temporal Concept=months Activity=inhaled 22 ==> Disease-Class=Asthma 22 conf:(1) 2126. Temporal Concept=period UNIT=% 22 ==> Disease-Class=Asthma 22 conf:(1) 2127. Temporal Concept=day SYMBOL=>= 22 ==> Disease-Class=Asthma 22 conf:(1) 2128. Temporal Concept=day Quantitative Concept=mcg 22 ==> Disease-Class=Asthma 22 conf:(1) 2129. Temporal Concept=day Activity=inhaled 22 ==> Disease-Class=Asthma 22 c onf:(1) 2130. Temporal Concept=post SYMBOL=- 22 ==> Disease-Class=Asthma 22 conf:(1) 2131. Temporal Concept=post UNIT=% 22 ==> Disease-Class=Asthma 22 conf:(1) 2132. Intellectual Product=method Organism Attribute=female 22 ==> Disease-Clas s=Asthma 22 conf:(1) 2133. Clinical Attribute=response UNIT=% 22 ==> Disease-Class=Asthma 22 conf :(1) 2134. Clinical Attribute=bmi Quantitative Concept=kg 22 ==> Disease-Class=Asthm a 22 conf:(1) 2135. Clinical Attribute=parenteral Individual Behavior=visit 22 ==> Disease-Cl ass=Asthma 22 conf:(1) 2136. Pharmacologic Substance=medications Laboratory Procedure=screening 22 ==> Disease-Class=Asthma 22 conf:(1) 2137. Pharmacologic Substance=medication NUMERAL=1.0 22 ==> Disease-Class=Asthm a 22 conf:(1) 2138. Pharmacologic Substance=corticosteroid Individual Behavior=visit 22 ==> D isease-Class=Asthma 22 conf:(1) 2139. Pharmacologic Substance=corticosteroids SYMBOL=> 22 ==> Disease-Class=Ast hma 22 conf:(1) 2140. NO=no Qualitative Concept=other 22 ==> Disease-Class=Asthma 22 conf:(1 ) 2141. NO=without Disease or Syndrome=asthma 22 ==> Disease-Class=Asthma 22 c onf:(1) 2142. NO=not Qualitative Concept=other 22 ==> Disease-Class=Asthma 22 conf:( 1) 2143. SYMBOL=- Idea or Concept=opinion 22 ==> Disease-Class=Asthma 22 conf:( 1) 2144. SYMBOL=- Qualitative Concept=inclusion criteria 22 ==> Disease-Class=Asth ma 22 conf:(1) 2145. SYMBOL=- Qualitative Concept=potential 22 ==> Disease-Class=Asthma 22

conf:(1) 2146. SYMBOL=- Spatial Concept=over 22 ==> Disease-Class=Asthma 22 conf:(1) 2147. SYMBOL=> Therapeutic or Preventive Procedure=treatment 22 ==> Disease-Cla ss=Asthma 22 conf:(1) 2148. SYMBOL=>= Quantitative Concept=baseline 22 ==> Disease-Class=Asthma 22 conf:(1) 2149. NUMERAL=2.0 Quantitative Concept=baseline 22 ==> Disease-Class=Asthma 22 conf:(1) 2150. NUMERAL=2.0 UNIT=% 22 ==> Disease-Class=Asthma 22 conf:(1) 2151. NUMERAL=2.0 Human=subjects 22 ==> Disease-Class=Asthma 22 conf:(1) 2152. NUMERAL=45.0 Research Activity=study 22 ==> Disease-Class=Asthma 22 co nf:(1) 2153. NUMERAL=45.0 Age Group=ages 22 ==> Disease-Class=Asthma 22 conf:(1) 2154. NUMERAL=85.0 UNIT=% 22 ==> Disease-Class=Asthma 22 conf:(1) 2155. NUMERAL=90.0 Idea or Concept=predicted 22 ==> Disease-Class=Asthma 22 conf:(1) 2156. Quantitative Concept=one Individual Behavior=visit 22 ==> Disease-Class=A sthma 22 conf:(1) 2157. Quantitative Concept=baseline Spatial Concept=within 22 ==> Disease-Class =Asthma 22 conf:(1) 2158. Quantitative Concept=dose Disease or Syndrome=ics 22 ==> Disease-Class=As thma 22 conf:(1) 2159. UNIT=% Finding=fall 22 ==> Disease-Class=Asthma 22 conf:(1) 2160. Organism Attribute=female Qualitative Concept=potential 22 ==> Disease-Cl ass=Asthma 22 conf:(1) 2161. Organism Attribute=female Disease or Syndrome=asthma 22 ==> Disease-Class =Asthma 22 conf:(1) 2162. Research Activity=study Organism Function=childbearing 22 ==> Disease-Cla ss=Asthma 22 conf:(1) 2163. Research Activity=study Allergy=allergy 22 ==> Disease-Class=Asthma 22 conf:(1) 2164. Research Activity=trial Individual Behavior=participation 22 ==> DiseaseClass=Asthma 22 conf:(1) 2165. Qualitative Concept=associated with Disease or Syndrome=asthma 22 ==> Dis ease-Class=Asthma 22 conf:(1) 2166. Qualitative Concept=associated with Sign or Symptom=seizures 22 ==> Disea se-Class=Asthma 22 conf:(1) 2167. Qualitative Concept=at risk Activity=put 22 ==> Disease-Class=Asthma 22 conf:(1) 2168. Therapeutic or Preventive Procedure=intubation Sign or Symptom=seizures 2 2 ==> Disease-Class=Asthma 22 conf:(1) 2169. Therapeutic or Preventive Procedure=procedures Compliance=comply 22 ==> D isease-Class=Asthma 22 conf:(1) 2170. Functional Concept=requiring Laboratory Procedure=screening 22 ==> Diseas e-Class=Asthma 22 conf:(1) 2171. Functional Concept=required Spatial Concept=within 22 ==> Disease-Class=A sthma 22 conf:(1) 2172. Functional Concept=give Finding=written 22 ==> Disease-Class=Asthma 22 conf:(1) 2173. Functional Concept=inclusive Age Group=aged 22 ==> Disease-Class=Asthma 2 2 conf:(1) 2174. Spatial Concept=within Behavior Problem=smoking 22 ==> Disease-Class=Asth ma 22 conf:(1) 2175. Organism Function=childbearing Contraception=contraception 22 ==> Disease -Class=Asthma 22 conf:(1) 2176. Disease or Syndrome=asthma Sign or Symptom=seizures 22 ==> Disease-Class= Asthma 22 conf:(1) 2177. Sign or Symptom=run Human=subject 22 ==> Disease-Class=Asthma 22 conf: (1) 2178. Health Care Activity=feeding SYMBOL=- Organism Function=pregnant 22 ==> D

isease-Class=Asthma 22 conf:(1) 2179. Temporal Concept=years SYMBOL=- Organism Attribute=female 22 ==> DiseaseClass=Asthma 22 conf:(1) 2180. Temporal Concept=prior to Pharmacologic Substance=medication Research Act ivity=study 22 ==> Disease-Class=Asthma 22 conf:(1) 2181. Temporal Concept=prior to NUMERAL=3.0 Laboratory Procedure=screening 22 = => Disease-Class=Asthma 22 conf:(1) 2182. Temporal Concept=prior to Research Activity=entry Spatial Concept=within 22 ==> Disease-Class=Asthma 22 conf:(1) 2183. Temporal Concept=prior to Spatial Concept=within Human=subjects 22 ==> Di sease-Class=Asthma 22 conf:(1) 2184. Temporal Concept=months Pharmacologic Substance=corticosteroids Body Spac e or Junction=oral 22 ==> Disease-Class=Asthma 22 conf:(1) 2185. Temporal Concept=months SYMBOL=> NUMERAL=6.0 22 ==> Disease-Class=Asthma 22 conf:(1) 2186. Clinical Attribute=parenteral Body Space or Junction=oral Individual Beha vior=visit 22 ==> Disease-Class=Asthma 22 conf:(1) 2187. Pharmacologic Substance=steroids Functional Concept=use of Activity=inhal ed 22 ==> Disease-Class=Asthma 22 conf:(1) 2188. Pharmacologic Substance=corticosteroids Therapeutic or Preventive Procedu re=treatment Disease or Syndrome=asthma 22 ==> Disease-Class=Asthma 22 conf:( 1) 2189. Pharmacologic Substance=corticosteroids Functional Concept=systemic Body Space or Junction=oral 22 ==> Disease-Class=Asthma 22 conf:(1) 2190. Pharmacologic Substance=corticosteroids Laboratory Procedure=screening In dividual Behavior=visit 22 ==> Disease-Class=Asthma 22 conf:(1) 2191. Pharmacologic Substance=bronchodilator SYMBOL=- UNIT=% 22 ==> Disease-Cla ss=Asthma 22 conf:(1) 2192. NO=not SYMBOL=- Individual Behavior=visit 22 ==> Disease-Class=Asthma 22 conf:(1) 2193. NO=not Laboratory Procedure=screening Individual Behavior=visit 22 ==> Di sease-Class=Asthma 22 conf:(1) 2194. SYMBOL=- NUMERAL=2.0 Qualitative Concept=beta 22 ==> Disease-Class=Asthma 22 conf:(1) 2195. SYMBOL=- NUMERAL=1.0 Research Activity=study 22 ==> Disease-Class=Asthma 22 conf:(1) 2196. SYMBOL=- UNIT=% Qualitative Concept=pre 22 ==> Disease-Class=Asthma 22 conf:(1) 2197. SYMBOL=- Organism Attribute=female Research Activity=study 22 ==> Disease -Class=Asthma 22 conf:(1) 2198. SYMBOL=- Idea or Concept=acting Functional Concept=use of 22 ==> DiseaseClass=Asthma 22 conf:(1) 2199. SYMBOL=- Idea or Concept=acting Spatial Concept=within 22 ==> Disease-Cla ss=Asthma 22 conf:(1) 2200. SYMBOL=- Idea or Concept=acting Laboratory Procedure=screening 22 ==> Dis ease-Class=Asthma 22 conf:(1) 2201. SYMBOL=- Research Activity=study Laboratory Procedure=screening 22 ==> Di sease-Class=Asthma 22 conf:(1) 2202. SYMBOL=- Qualitative Concept=beta Spatial Concept=within 22 ==> Disease-C lass=Asthma 22 conf:(1) 2203. SYMBOL=- Functional Concept=requiring Disease or Syndrome=asthma 22 ==> D isease-Class=Asthma 22 conf:(1) 2204. SYMBOL=- Sign or Symptom=run Human=subject 22 ==> Disease-Class=Asthma 22 conf:(1) 2205. SYMBOL=- Diagnostic Procedure=fev1 Individual Behavior=visit 22 ==> Disea se-Class=Asthma 22 conf:(1) 2206. SYMBOL=>= NUMERAL=12.0 UNIT=% 22 ==> Disease-Class=Asthma 22 conf:(1) 2207. SYMBOL=>= NUMERAL=12.0 Disease or Syndrome=asthma 22 ==> Disease-Class=As thma 22 conf:(1) 2208. NUMERAL=10.0 Quantitative Concept=pack Spatial Concept=within 22 ==> Dise

ase-Class=Asthma 22 conf:(1) 2209. NUMERAL=10.0 Spatial Concept=within Finding=smoking history 22 ==> Diseas e-Class=Asthma 22 conf:(1) 2210. NUMERAL=1.0 Quantitative Concept=exacerbation Individual Behavior=visit 2 2 ==> Disease-Class=Asthma 22 conf:(1) 2211. NUMERAL=1.0 Therapeutic or Preventive Procedure=treatment Spatial Concept =within 22 ==> Disease-Class=Asthma 22 conf:(1) 2212. NUMERAL=90.0 UNIT=% Idea or Concept=predicted 22 ==> Disease-Class=Asthma 22 conf:(1) 2213. Idea or Concept=predicted Laboratory Procedure=screening Individual Behav ior=visit 22 ==> Disease-Class=Asthma 22 conf:(1) 2214. Idea or Concept=acting Laboratory Procedure=screening Activity=inhaled 22 ==> Disease-Class=Asthma 22 conf:(1) 2215. Research Activity=study Disease or Syndrome=disease Professional or Occup ational Group=investigator 22 ==> Disease-Class=Asthma 22 conf:(1) 2216. Functional Concept=use of Spatial Concept=within Activity=inhaled 22 ==> Disease-Class=Asthma 22 conf:(1) 2217. Functional Concept=give Regulation or Law=informed consent Willing=willin g 22 ==> Disease-Class=Asthma 22 conf:(1) 2218. Laboratory Procedure=screening Individual Behavior=visit Human=subjects 2 2 ==> Disease-Class=Asthma 22 conf:(1) 2219. Temporal Concept=prior to SYMBOL=- Spatial Concept=within Individual Beha vior=visit 22 ==> Disease-Class=Asthma 22 conf:(1) 2220. Temporal Concept=prior to SYMBOL=>= NUMERAL=1.0 Individual Behavior=visit 22 ==> Disease-Class=Asthma 22 conf:(1) 2221. Pharmacologic Substance=agonist SYMBOL=- Quantitative Concept=short Idea or Concept=acting 22 ==> Disease-Class=Asthma 22 conf:(1) 2222. SYMBOL=- NUMERAL=10.0 Quantitative Concept=pack Spatial Concept=within 22 ==> Disease-Class=Asthma 22 conf:(1) 2223. SYMBOL=- Quantitative Concept=short Idea or Concept=acting Individual Beh avior=visit 22 ==> Disease-Class=Asthma 22 conf:(1) 2224. SYMBOL=- UNIT=% Laboratory Procedure=screening Diagnostic Procedure=fev1 22 ==> Disease-Class=Asthma 22 conf:(1) 2225. Quantitative Concept=value UNIT=% Idea or Concept=predicted Diagnostic Pr ocedure=fev1 22 ==> Disease-Class=Asthma 22 conf:(1) 2226. Spatial Concept=within Laboratory Procedure=screening Body Space or Junct ion=oral Individual Behavior=visit 22 ==> Disease-Class=Asthma 22 conf:(1) 2227. Temporal Concept=years SYMBOL=- NUMERAL=10.0 Quantitative Concept=pack Fi nding=smoking history 22 ==> Disease-Class=Asthma 22 conf:(1) 2228. Pharmacologic Substance=corticosteroids NUMERAL=1.0 Spatial Concept=withi n Body Space or Junction=oral Individual Behavior=visit 22 ==> Disease-Class=Ast hma 22 conf:(1) 2229. Health Care Activity=admission 21 ==> Disease-Class=Asthma 21 conf:(1) 2230. Temporal Concept=through 21 ==> Disease-Class=Asthma 21 conf:(1) 2231. NUMERAL=2000.0 21 ==> Disease-Class=Asthma 21 conf:(1) 2232. Quantitative Concept=mg 21 ==> Disease-Class=Asthma 21 conf:(1) 2233. Quantitative Concept=cannot 21 ==> Disease-Class=Asthma 21 conf:(1) 2234. Organism Attribute=sex 21 ==> Disease-Class=Asthma 21 conf:(1) 2235. Idea or Concept=no history of 21 ==> Disease-Class=Asthma 21 conf:(1) 2236. Idea or Concept=information 21 ==> Disease-Class=Asthma 21 conf:(1) 2237. Research Activity=clinical study 21 ==> Disease-Class=Asthma 21 conf:( 1) 2238. Qualitative Concept=performed 21 ==> Disease-Class=Asthma 21 conf:(1) 2239. Qualitative Concept=contraindications 21 ==> Disease-Class=Asthma 21 c onf:(1) 2240. Qualitative Concept=status 21 ==> Disease-Class=Asthma 21 conf:(1) 2241. Functional Concept=require 21 ==> Disease-Class=Asthma 21 conf:(1) 2242. Functional Concept=induced 21 ==> Disease-Class=Asthma 21 conf:(1) 2243. Functional Concept=outcome 21 ==> Disease-Class=Asthma 21 conf:(1) 2244. Spatial Concept=global 21 ==> Disease-Class=Asthma 21 conf:(1)

2245. Spatial Concept=end 21 ==> Disease-Class=Asthma 21 conf:(1) 2246. Spatial Concept=local 21 ==> Disease-Class=Asthma 21 conf:(1) 2247. Organism Function=lactation 21 ==> Disease-Class=Asthma 21 conf:(1) 2248. Organism Function=breast feeding 21 ==> Disease-Class=Asthma 21 conf:( 1) 2249. Organism Function=inhalations 21 ==> Disease-Class=Asthma 21 conf:(1) 2250. Disease or Syndrome=bronchiectasis 21 ==> Disease-Class=Asthma 21 conf :(1) 2251. Laboratory Procedure=gcs 21 ==> Disease-Class=Asthma 21 conf:(1) 2252. Finding=corticosteroid use 21 ==> Disease-Class=Asthma 21 conf:(1) 2253. Finding=alone 21 ==> Disease-Class=Asthma 21 conf:(1) 2254. Finding=compromise 21 ==> Disease-Class=Asthma 21 conf:(1) 2255. Finding=indicated 21 ==> Disease-Class=Asthma 21 conf:(1) 2256. MARK=+ 21 ==> Disease-Class=Asthma 21 conf:(1) 2257. Professional or Occupational Group=doctor 21 ==> Disease-Class=Asthma 21 conf:(1) 2258. Sign or Symptom=medical conditions 21 ==> Disease-Class=Asthma 21 conf :(1) 2259. Chemical Viewed Functionally=ingredients 21 ==> Disease-Class=Asthma 21 conf:(1) 2260. Organic Chemical=cfc 21 ==> Disease-Class=Asthma 21 conf:(1) 2261. Mental Process=initiative 21 ==> Disease-Class=Asthma 21 conf:(1) 2262. Mental Process=intention 21 ==> Disease-Class=Asthma 21 conf:(1) 2263. Exercise=exercise 21 ==> Disease-Class=Asthma 21 conf:(1) 2264. Patient or Disabled Group=patients NO=excluded 21 ==> Disease-Class=Asthm a 21 conf:(1) 2265. Patient or Disabled Group=patients SYMBOL=< 21 ==> Disease-Class=Asthma 2 1 conf:(1) 2266. Patient or Disabled Group=patients Qualitative Concept=from 21 ==> Diseas e-Class=Asthma 21 conf:(1) 2267. Patient or Disabled Group=patients Spatial Concept=between 21 ==> Disease -Class=Asthma 21 conf:(1) 2268. Patient or Disabled Group=patients Age Group=aged 21 ==> Disease-Class=As thma 21 conf:(1) 2269. Patient or Disabled Group=patient UNIT=% 21 ==> Disease-Class=Asthma 21 conf:(1) 2270. Health Care Activity=hospitalization Therapeutic or Preventive Procedure= treatment 21 ==> Disease-Class=Asthma 21 conf:(1) 2271. Temporal Concept=years SYMBOL=< 21 ==> Disease-Class=Asthma 21 conf:(1 ) 2272. Temporal Concept=years Behavior Problem=smoking 21 ==> Disease-Class=Asth ma 21 conf:(1) 2273. Temporal Concept=prior to Therapeutic or Preventive Procedure=therapy 21 ==> Disease-Class=Asthma 21 conf:(1) 2274. Temporal Concept=months Therapeutic or Preventive Procedure=treatment 21 ==> Disease-Class=Asthma 21 conf:(1) 2275. Temporal Concept=period NUMERAL=4.0 21 ==> Disease-Class=Asthma 21 con f:(1) 2276. Temporal Concept=before Activity=inhaled 21 ==> Disease-Class=Asthma 21 conf:(1) 2277. Temporal Concept=preceding Spatial Concept=within 21 ==> Disease-Class=As thma 21 conf:(1) 2278. Intellectual Product=criteria Individual Behavior=visit 21 ==> Disease-Cl ass=Asthma 21 conf:(1) 2279. Intellectual Product=criteria Human=subject 21 ==> Disease-Class=Asthma 2 1 conf:(1) 2280. Clinical Attribute=bmi UNIT=m2 21 ==> Disease-Class=Asthma 21 conf:(1) 2281. Pharmacologic Substance=agonists Quantitative Concept=short 21 ==> Diseas e-Class=Asthma 21 conf:(1) 2282. Pharmacologic Substance=medication SYMBOL=>= 21 ==> Disease-Class=Asthma

21 conf:(1) 2283. Pharmacologic Substance=agonist UNIT=% 21 ==> Disease-Class=Asthma 21 conf:(1) 2284. Pharmacologic Substance=agonist Laboratory Procedure=screening 21 ==> Dis ease-Class=Asthma 21 conf:(1) 2285. Pharmacologic Substance=salbutamol Spatial Concept=within 21 ==> DiseaseClass=Asthma 21 conf:(1) 2286. Pharmacologic Substance=salbutamol Organism Function=inhalation 21 ==> Di sease-Class=Asthma 21 conf:(1) 2287. NO=excluded Research Activity=study 21 ==> Disease-Class=Asthma 21 con f:(1) 2288. NO=excluded Qualitative Concept=from 21 ==> Disease-Class=Asthma 21 co nf:(1) 2289. NO=not Idea or Concept=eligible 21 ==> Disease-Class=Asthma 21 conf:(1 ) 2290. NO=not Body Space or Junction=oral 21 ==> Disease-Class=Asthma 21 conf :(1) 2291. SYMBOL=- NUMERAL=65.0 21 ==> Disease-Class=Asthma 21 conf:(1) 2292. SYMBOL=- Quantitative Concept=exacerbation 21 ==> Disease-Class=Asthma 21 conf:(1) 2293. SYMBOL=- Qualitative Concept=positive 21 ==> Disease-Class=Asthma 21 c onf:(1) 2294. SYMBOL=- Functional Concept=used 21 ==> Disease-Class=Asthma 21 conf:( 1) 2295. SYMBOL=- Sign or Symptom=seizures 21 ==> Disease-Class=Asthma 21 conf: (1) 2296. SYMBOL=> NUMERAL=70.0 21 ==> Disease-Class=Asthma 21 conf:(1) 2297. SYMBOL=> Qualitative Concept=last 21 ==> Disease-Class=Asthma 21 conf: (1) 2298. SYMBOL=< Human=subject 21 ==> Disease-Class=Asthma 21 conf:(1) 2299. SYMBOL=>= Diagnostic Procedure=diagnosed 21 ==> Disease-Class=Asthma 21 conf:(1) 2300. NUMERAL=5.0 Finding=lives 21 ==> Disease-Class=Asthma 21 conf:(1) 2301. NUMERAL=6.0 Therapeutic or Preventive Procedure=treatment 21 ==> DiseaseClass=Asthma 21 conf:(1) 2302. NUMERAL=6.0 Body Space or Junction=oral 21 ==> Disease-Class=Asthma 21 conf:(1) 2303. NUMERAL=20.0 Diagnostic Procedure=fev1 21 ==> Disease-Class=Asthma 21 conf:(1) 2304. NUMERAL=3.0 Activity=inhaled 21 ==> Disease-Class=Asthma 21 conf:(1) 2305. NUMERAL=3.0 Human=subject 21 ==> Disease-Class=Asthma 21 conf:(1) 2306. NUMERAL=45.0 Idea or Concept=eligible 21 ==> Disease-Class=Asthma 21 c onf:(1) 2307. NUMERAL=1.0 Functional Concept=use 21 ==> Disease-Class=Asthma 21 conf :(1) 2308. NUMERAL=12.0 Age Group=age 21 ==> Disease-Class=Asthma 21 conf:(1) 2309. NUMERAL=70.0 Age Group=age 21 ==> Disease-Class=Asthma 21 conf:(1) 2310. NUMERAL=17.0 Age Group=ages 21 ==> Disease-Class=Asthma 21 conf:(1) 2311. Quantitative Concept=all Human=subjects 21 ==> Disease-Class=Asthma 21 conf:(1) 2312. UNIT=% Organ or Tissue Function=fev 21 ==> Disease-Class=Asthma 21 con f:(1) 2313. UNIT=time Disease or Syndrome=asthma 21 ==> Disease-Class=Asthma 21 co nf:(1) 2314. Organism Attribute=female Functional Concept=using 21 ==> Disease-Class=A sthma 21 conf:(1) 2315. Idea or Concept=predicted Spatial Concept=between 21 ==> Disease-Class=As thma 21 conf:(1) 2316. Research Activity=study Qualitative Concept=at risk 21 ==> Disease-Class= Asthma 21 conf:(1)

2317. Research Activity=study Therapeutic or Preventive Procedure=therapy 21 == > Disease-Class=Asthma 21 conf:(1) 2318. Research Activity=study Activity=take 21 ==> Disease-Class=Asthma 21 c onf:(1) 2319. Research Activity=study Contraception=birth control 21 ==> Disease-Class= Asthma 21 conf:(1) 2320. Research Activity=study Contraception=condom 21 ==> Disease-Class=Asthma 21 conf:(1) 2321. Qualitative Concept=negative Organism Function=pregnancy test 21 ==> Dise ase-Class=Asthma 21 conf:(1) 2322. Qualitative Concept=positive Laboratory Procedure=test 21 ==> Disease-Cla ss=Asthma 21 conf:(1) 2323. Qualitative Concept=beta Therapeutic or Preventive Procedure=treatment 21 ==> Disease-Class=Asthma 21 conf:(1) 2324. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation 21 ==> Disease-Class=Asthma 21 conf:(1) 2325. Qualitative Concept=associated with Finding=life 21 ==> Disease-Class=Ast hma 21 conf:(1) 2326. Qualitative Concept=from Functional Concept=including 21 ==> Disease-Clas s=Asthma 21 conf:(1) 2327. Qualitative Concept=significant Professional or Occupational Group=invest igator 21 ==> Disease-Class=Asthma 21 conf:(1) 2328. Qualitative Concept=long Activity=inhaled 21 ==> Disease-Class=Asthma 21 conf:(1) 2329. Therapeutic or Preventive Procedure=treatment Health Care Related Organiz ation=emergency room 21 ==> Disease-Class=Asthma 21 conf:(1) 2330. Therapeutic or Preventive Procedure=therapy Spatial Concept=within 21 ==> Disease-Class=Asthma 21 conf:(1) 2331. Therapeutic or Preventive Procedure=intubation Pathologic Function=hypoxi c 21 ==> Disease-Class=Asthma 21 conf:(1) 2332. Therapeutic or Preventive Procedure=procedures Willing=willing 21 ==> Dis ease-Class=Asthma 21 conf:(1) 2333. Therapeutic or Preventive Procedure=procedures Capacity=able to 21 ==> Di sease-Class=Asthma 21 conf:(1) 2334. Functional Concept=participate Capacity=ability 21 ==> Disease-Class=Asth ma 21 conf:(1) 2335. Functional Concept=including Human=subject 21 ==> Disease-Class=Asthma 21 conf:(1) 2336. Functional Concept=increase Individual Behavior=visit 21 ==> Disease-Clas s=Asthma 21 conf:(1) 2337. Functional Concept=start Human=subject 21 ==> Disease-Class=Asthma 21 conf:(1) 2338. Spatial Concept=within Organism Function=inhalation 21 ==> Disease-Class= Asthma 21 conf:(1) 2339. Spatial Concept=within Health Care Related Organization=emergency room 21 ==> Disease-Class=Asthma 21 conf:(1) 2340. Spatial Concept=global Mental Process=initiative 21 ==> Disease-Class=Ast hma 21 conf:(1) 2341. Disease or Syndrome=asthma Age Group=aged 21 ==> Disease-Class=Asthma 21 conf:(1) 2342. Disease or Syndrome=asthma Age Group=children 21 ==> Disease-Class=Asthma 21 conf:(1) 2343. Disease or Syndrome=asthma Phenomenon or Process=unstable 21 ==> DiseaseClass=Asthma 21 conf:(1) 2344. Finding=life Sign or Symptom=seizures 21 ==> Disease-Class=Asthma 21 c onf:(1) 2345. Mental Process=understand Capacity=able to 21 ==> Disease-Class=Asthma 21 conf:(1) 2346. Patient or Disabled Group=patients Research Activity=study Disease or Syn drome=asthma 21 ==> Disease-Class=Asthma 21 conf:(1)

2347. Temporal Concept=years NUMERAL=45.0 Idea or Concept=eligible 21 ==> Disea se-Class=Asthma 21 conf:(1) 2348. Temporal Concept=years NUMERAL=45.0 Research Activity=study 21 ==> Diseas e-Class=Asthma 21 conf:(1) 2349. Temporal Concept=years NUMERAL=45.0 Age Group=ages 21 ==> Disease-Class=A sthma 21 conf:(1) 2350. Temporal Concept=history of SYMBOL=- Finding=life 21 ==> Disease-Class=As thma 21 conf:(1) 2351. Temporal Concept=after SYMBOL=- UNIT=% 21 ==> Disease-Class=Asthma 21 conf:(1) 2352. Temporal Concept=prior to Pharmacologic Substance=medication Spatial Conc ept=within 21 ==> Disease-Class=Asthma 21 conf:(1) 2353. Temporal Concept=prior to Pharmacologic Substance=medication Disease or S yndrome=asthma 21 ==> Disease-Class=Asthma 21 conf:(1) 2354. Temporal Concept=prior to Pharmacologic Substance=corticosteroids Spatial Concept=within 21 ==> Disease-Class=Asthma 21 conf:(1) 2355. Temporal Concept=prior to SYMBOL=- Idea or Concept=acting 21 ==> DiseaseClass=Asthma 21 conf:(1) 2356. Temporal Concept=prior to SYMBOL=>= NUMERAL=6.0 21 ==> Disease-Class=Asth ma 21 conf:(1) 2357. Temporal Concept=weeks NUMERAL=2.0 Spatial Concept=within 21 ==> DiseaseClass=Asthma 21 conf:(1) 2358. Temporal Concept=weeks NUMERAL=4.0 Activity=inhaled 21 ==> Disease-Class= Asthma 21 conf:(1) 2359. Temporal Concept=period SYMBOL=- Research Activity=study 21 ==> Disease-C lass=Asthma 21 conf:(1) 2360. Intellectual Product=pack years SYMBOL=> Spatial Concept=within 21 ==> Di sease-Class=Asthma 21 conf:(1) 2361. Clinical Attribute=bmi Quantitative Concept=kg UNIT=m2 21 ==> Disease-Cla ss=Asthma 21 conf:(1) 2362. Pharmacologic Substance=pef UNIT=% Diagnostic Procedure=fev1 21 ==> Disea se-Class=Asthma 21 conf:(1) 2363. Pharmacologic Substance=bronchodilator SYMBOL=- Diagnostic Procedure=fev1 21 ==> Disease-Class=Asthma 21 conf:(1) 2364. NO=not NUMERAL=1.0 Research Activity=study 21 ==> Disease-Class=Asthma 21 conf:(1) 2365. SYMBOL=- NUMERAL=4.0 Disease or Syndrome=asthma 21 ==> Disease-Class=Asth ma 21 conf:(1) 2366. SYMBOL=- NUMERAL=1.0 Disease or Syndrome=asthma 21 ==> Disease-Class=Asth ma 21 conf:(1) 2367. SYMBOL=- UNIT=% Spatial Concept=within 21 ==> Disease-Class=Asthma 21 conf:(1) 2368. SYMBOL=- Idea or Concept=predicted Individual Behavior=visit 21 ==> Disea se-Class=Asthma 21 conf:(1) 2369. SYMBOL=- Idea or Concept=acting Body Space or Junction=oral 21 ==> Diseas e-Class=Asthma 21 conf:(1) 2370. SYMBOL=- Qualitative Concept=beta Disease or Syndrome=asthma 21 ==> Disea se-Class=Asthma 21 conf:(1) 2371. SYMBOL=- Qualitative Concept=associated with Finding=life 21 ==> DiseaseClass=Asthma 21 conf:(1) 2372. SYMBOL=- Qualitative Concept=associated with Sign or Symptom=seizures 21 ==> Disease-Class=Asthma 21 conf:(1) 2373. SYMBOL=- Disease or Syndrome=asthma Sign or Symptom=symptoms 21 ==> Disea se-Class=Asthma 21 conf:(1) 2374. SYMBOL=- Finding=life Sign or Symptom=seizures 21 ==> Disease-Class=Asthm a 21 conf:(1) 2375. SYMBOL=- Professional or Occupational Group=investigator Human=subject 21 ==> Disease-Class=Asthma 21 conf:(1) 2376. SYMBOL=- Activity=inhaled Individual Behavior=visit 21 ==> Disease-Class= Asthma 21 conf:(1)

2377. SYMBOL=> UNIT=% Disease or Syndrome=asthma 21 ==> Disease-Class=Asthma 21 conf:(1) 2378. SYMBOL=>= Quantitative Concept=one Disease or Syndrome=asthma 21 ==> Dise ase-Class=Asthma 21 conf:(1) 2379. SYMBOL=>= Disease or Syndrome=asthma Sign or Symptom=symptoms 21 ==> Dise ase-Class=Asthma 21 conf:(1) 2380. SYMBOL=>= Disease or Syndrome=asthma Individual Behavior=visit 21 ==> Dis ease-Class=Asthma 21 conf:(1) 2381. NUMERAL=45.0 Idea or Concept=eligible Research Activity=study 21 ==> Dise ase-Class=Asthma 21 conf:(1) 2382. NUMERAL=45.0 Idea or Concept=eligible Age Group=ages 21 ==> Disease-Class =Asthma 21 conf:(1) 2383. NUMERAL=45.0 Research Activity=study Age Group=ages 21 ==> Disease-Class= Asthma 21 conf:(1) 2384. NUMERAL=1.0 Spatial Concept=within Activity=inhaled 21 ==> Disease-Class= Asthma 21 conf:(1) 2385. NUMERAL=1.0 Spatial Concept=within Human=subject 21 ==> Disease-Class=Ast hma 21 conf:(1) 2386. NUMERAL=1.0 Diagnostic Procedure=fev1 Individual Behavior=visit 21 ==> Di sease-Class=Asthma 21 conf:(1) 2387. NUMERAL=90.0 Idea or Concept=predicted Diagnostic Procedure=fev1 21 ==> D isease-Class=Asthma 21 conf:(1) 2388. Quantitative Concept=exacerbation Disease or Syndrome=asthma Individual B ehavior=visit 21 ==> Disease-Class=Asthma 21 conf:(1) 2389. Idea or Concept=continue Research Activity=study Willing=agree 21 ==> Dis ease-Class=Asthma 21 conf:(1) 2390. Idea or Concept=acting Therapeutic or Preventive Procedure=treatment Acti vity=inhaled 21 ==> Disease-Class=Asthma 21 conf:(1) 2391. Idea or Concept=opinion Research Activity=study Human=subject 21 ==> Dise ase-Class=Asthma 21 conf:(1) 2392. Idea or Concept=opinion Activity=put Individual Behavior=participation 21 ==> Disease-Class=Asthma 21 conf:(1) 2393. Research Activity=study Therapeutic or Preventive Procedure=procedures Wi lling=willing 21 ==> Disease-Class=Asthma 21 conf:(1) 2394. Research Activity=study Functional Concept=participate Professional or Oc cupational Group=investigator 21 ==> Disease-Class=Asthma 21 conf:(1) 2395. Research Activity=study Functional Concept=start Human=subject 21 ==> Dis ease-Class=Asthma 21 conf:(1) 2396. Research Activity=study Professional or Occupational Group=investigator A ctivity=interfere 21 ==> Disease-Class=Asthma 21 conf:(1) 2397. Research Activity=study Professional or Occupational Group=investigator C apacity=ability 21 ==> Disease-Class=Asthma 21 conf:(1) 2398. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Sign or Symptom=seizures 21 ==> Disease-Class=Asthma 21 conf:(1) 2399. Qualitative Concept=associated with Disease or Syndrome=asthma Sign or Sy mptom=seizures 21 ==> Disease-Class=Asthma 21 conf:(1) 2400. Qualitative Concept=associated with Finding=life Sign or Symptom=seizures 21 ==> Disease-Class=Asthma 21 conf:(1) 2401. Therapeutic or Preventive Procedure=intubation Pathologic Function=hypoxi c Disease or Syndrome=asthma 21 ==> Disease-Class=Asthma 21 conf:(1) 2402. Therapeutic or Preventive Procedure=intubation Disease or Syndrome=asthma Sign or Symptom=seizures 21 ==> Disease-Class=Asthma 21 conf:(1) 2403. Functional Concept=use of Spatial Concept=within Laboratory Procedure=scr eening 21 ==> Disease-Class=Asthma 21 conf:(1) 2404. Functional Concept=use of Spatial Concept=within Individual Behavior=visi t 21 ==> Disease-Class=Asthma 21 conf:(1) 2405. Functional Concept=give Finding=written Regulation or Law=informed consen t 21 ==> Disease-Class=Asthma 21 conf:(1) 2406. Spatial Concept=within Laboratory Procedure=screening Activity=inhaled 21 ==> Disease-Class=Asthma 21 conf:(1)

2407. Spatial Concept=within Laboratory Procedure=screening Human=subjects 21 = => Disease-Class=Asthma 21 conf:(1) 2408. Professional or Occupational Group=investigator Activity=put Individual B ehavior=participation 21 ==> Disease-Class=Asthma 21 conf:(1) 2409. Temporal Concept=years NUMERAL=45.0 Idea or Concept=eligible Research Act ivity=study 21 ==> Disease-Class=Asthma 21 conf:(1) 2410. Temporal Concept=years NUMERAL=45.0 Idea or Concept=eligible Age Group=ag es 21 ==> Disease-Class=Asthma 21 conf:(1) 2411. Temporal Concept=years NUMERAL=45.0 Research Activity=study Age Group=age s 21 ==> Disease-Class=Asthma 21 conf:(1) 2412. Pharmacologic Substance=agonist SYMBOL=- Idea or Concept=acting Activity= inhaled 21 ==> Disease-Class=Asthma 21 conf:(1) 2413. NO=not NUMERAL=1.0 Individual Behavior=visit Human=subject 21 ==> Disease -Class=Asthma 21 conf:(1) 2414. SYMBOL=- Qualitative Concept=associated with Finding=life Sign or Symptom =seizures 21 ==> Disease-Class=Asthma 21 conf:(1) 2415. SYMBOL=- Disease or Syndrome=asthma Professional or Occupational Group=ph ysician Diagnostic Procedure=diagnosed 21 ==> Disease-Class=Asthma 21 conf:(1 ) 2416. NUMERAL=45.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 21 ==> Disease-Class=Asthma 21 conf:(1) 2417. NUMERAL=90.0 UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 2 1 ==> Disease-Class=Asthma 21 conf:(1) 2418. Laboratory or Test Result=pc20 UNIT=% Diagnostic Procedure=fev1 Organic C hemical=methacholine 21 ==> Disease-Class=Asthma 21 conf:(1) 2419. Idea or Concept=opinion Professional or Occupational Group=investigator A ctivity=put Individual Behavior=participation 21 ==> Disease-Class=Asthma 21 conf:(1) 2420. Spatial Concept=within Disease or Syndrome=asthma Laboratory Procedure=sc reening Individual Behavior=visit 21 ==> Disease-Class=Asthma 21 conf:(1) 2421. Temporal Concept=years NUMERAL=45.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 21 ==> Disease-Class=Asthma 21 conf:(1) 2422. Health Care Activity=drug administration 20 ==> Disease-Class=Asthma 20 conf:(1) 2423. Temporal Concept=throughout 20 ==> Disease-Class=Asthma 20 conf:(1) 2424. Temporal Concept=episode 20 ==> Disease-Class=Asthma 20 conf:(1) 2425. Intellectual Product=criterion 20 ==> Disease-Class=Asthma 20 conf:(1) 2426. Clinical Attribute=body weight 20 ==> Disease-Class=Asthma 20 conf:(1) 2427. Pharmacologic Substance=dpi 20 ==> Disease-Class=Asthma 20 conf:(1) 2428. Pharmacologic Substance=blockers 20 ==> Disease-Class=Asthma 20 conf:( 1) 2429. NUMERAL=100.0 20 ==> Disease-Class=Asthma 20 conf:(1) 2430. Quantitative Concept=normal value 20 ==> Disease-Class=Asthma 20 conf: (1) 2431. UNIT=l 20 ==> Disease-Class=Asthma 20 conf:(1) 2432. Qualitative Concept=consistent with 20 ==> Disease-Class=Asthma 20 con f:(1) 2433. Disease or Syndrome=chronic obstructive pulmonary disease 20 ==> DiseaseClass=Asthma 20 conf:(1) 2434. Neoplastic Process=basal cell carcinoma 20 ==> Disease-Class=Asthma 20 conf:(1) 2435. Finding=current smoker 20 ==> Disease-Class=Asthma 20 conf:(1) 2436. Biologically Active Substance=component 20 ==> Disease-Class=Asthma 20 conf:(1) 2437. Antibiotic=antibiotics 20 ==> Disease-Class=Asthma 20 conf:(1) 2438. Conceptual Entity=precautions 20 ==> Disease-Class=Asthma 20 conf:(1) 2439. Medical Device=barrier 20 ==> Disease-Class=Asthma 20 conf:(1) 2440. Chemical Viewed Functionally=modifiers 20 ==> Disease-Class=Asthma 20 conf:(1) 2441. Immunologic Factor=allergens 20 ==> Disease-Class=Asthma 20 conf:(1)

2442. Immunologic Factor=prohibited 20 ==> Disease-Class=Asthma 20 conf:(1) 2443. Contraception=contraceptive 20 ==> Disease-Class=Asthma 20 conf:(1) 2444. Patient or Disabled Group=patients NUMERAL=10.0 20 ==> Disease-Class=Asth ma 20 conf:(1) 2445. Patient or Disabled Group=patients Quantitative Concept=exacerbation 20 = => Disease-Class=Asthma 20 conf:(1) 2446. Patient or Disabled Group=patient Temporal Concept=years 20 ==> Disease-C lass=Asthma 20 conf:(1) 2447. Patient or Disabled Group=patient NUMERAL=1.0 20 ==> Disease-Class=Asthma 20 conf:(1) 2448. Patient or Disabled Group=patient Activity=put 20 ==> Disease-Class=Asthm a 20 conf:(1) 2449. Health Care Activity=diagnosis Temporal Concept=prior to 20 ==> Disease-C lass=Asthma 20 conf:(1) 2450. Temporal Concept=history of NUMERAL=10.0 20 ==> Disease-Class=Asthma 20 conf:(1) 2451. Temporal Concept=history of Behavior Problem=smoking 20 ==> Disease-Class =Asthma 20 conf:(1) 2452. Temporal Concept=prior to Functional Concept=used 20 ==> Disease-Class=As thma 20 conf:(1) 2453. Temporal Concept=prior to Sign or Symptom=symptoms 20 ==> Disease-Class=A sthma 20 conf:(1) 2454. Temporal Concept=weeks Human=subjects 20 ==> Disease-Class=Asthma 20 c onf:(1) 2455. Temporal Concept=months Quantitative Concept=or more 20 ==> Disease-Class =Asthma 20 conf:(1) 2456. Temporal Concept=period Human=subject 20 ==> Disease-Class=Asthma 20 c onf:(1) 2457. Temporal Concept=daily SYMBOL=- 20 ==> Disease-Class=Asthma 20 conf:(1 ) 2458. Temporal Concept=daily Disease or Syndrome=asthma 20 ==> Disease-Class=As thma 20 conf:(1) 2459. Temporal Concept=month Body Space or Junction=oral 20 ==> Disease-Class=A sthma 20 conf:(1) 2460. Temporal Concept=before Pharmacologic Substance=medication 20 ==> Disease -Class=Asthma 20 conf:(1) 2461. Temporal Concept=post Diagnostic Procedure=fev1 20 ==> Disease-Class=Asth ma 20 conf:(1) 2462. Intellectual Product=methods Functional Concept=using 20 ==> Disease-Clas s=Asthma 20 conf:(1) 2463. Intellectual Product=method Population Group=women 20 ==> Disease-Class=A sthma 20 conf:(1) 2464. Intellectual Product=method Contraception=birth control 20 ==> Disease-Cl ass=Asthma 20 conf:(1) 2465. Pharmacologic Substance=agonists Disease or Syndrome=asthma 20 ==> Diseas e-Class=Asthma 20 conf:(1) 2466. Pharmacologic Substance=medication Qualitative Concept=last 20 ==> Diseas e-Class=Asthma 20 conf:(1) 2467. Pharmacologic Substance=agonist SYMBOL=>= 20 ==> Disease-Class=Asthma 20 conf:(1) 2468. Pharmacologic Substance=corticosteroids SYMBOL=>= 20 ==> Disease-Class=As thma 20 conf:(1) 2469. Pharmacologic Substance=corticosteroids Human=subjects 20 ==> Disease-Cla ss=Asthma 20 conf:(1) 2470. Pharmacologic Substance=investigational drug Research Activity=study 20 = => Disease-Class=Asthma 20 conf:(1) 2471. NO=no Activity=inhaled 20 ==> Disease-Class=Asthma 20 conf:(1) 2472. NO=not Idea or Concept=acting 20 ==> Disease-Class=Asthma 20 conf:(1) 2473. NO=not Functional Concept=limited 20 ==> Disease-Class=Asthma 20 conf: (1)

2474. NO=not Functional Concept=use 20 ==> Disease-Class=Asthma 20 conf:(1) 2475. NO=not Sign or Symptom=symptoms 20 ==> Disease-Class=Asthma 20 conf:(1 ) 2476. 2477. 20 2478. ) 2479. SYMBOL=- Willing=willing 20 ==> Disease-Class=Asthma 20 conf:(1) 2480. SYMBOL=>= Research Activity=entry 20 ==> Disease-Class=Asthma 20 conf: (1) 2481. SYMBOL=>= Body Space or Junction=oral 20 ==> Disease-Class=Asthma 20 c onf:(1) 2482. NUMERAL=30.0 Functional Concept=use of 20 ==> Disease-Class=Asthma 20 conf:(1) 2483. NUMERAL=4.0 Quantitative Concept=dose 20 ==> Disease-Class=Asthma 20 c onf:(1) 2484. NUMERAL=18.0 Organism Attribute=female 20 ==> Disease-Class=Asthma 20 conf:(1) 2485. NUMERAL=85.0 Diagnostic Procedure=fev1 20 ==> Disease-Class=Asthma 20 conf:(1) 2486. NUMERAL=17.0 Idea or Concept=eligible 20 ==> Disease-Class=Asthma 20 c onf:(1) 2487. Quantitative Concept=exacerbations Disease or Syndrome=asthma 20 ==> Dise ase-Class=Asthma 20 conf:(1) 2488. Quantitative Concept=pack Therapeutic or Preventive Procedure=ex 20 ==> D isease-Class=Asthma 20 conf:(1) 2489. Quantitative Concept=two Disease or Syndrome=asthma 20 ==> Disease-Class= Asthma 20 conf:(1) 2490. Quantitative Concept=normal value UNIT=% 20 ==> Disease-Class=Asthma 20 conf:(1) 2491. Quantitative Concept=first Spatial Concept=within 20 ==> Disease-Class=As thma 20 conf:(1) 2492. Quantitative Concept=could Professional or Occupational Group=investigato r 20 ==> Disease-Class=Asthma 20 conf:(1) 2493. UNIT=% Age Group=age 20 ==> Disease-Class=Asthma 20 conf:(1) 2494. Organism Attribute=female Organism Function=lactating 20 ==> Disease-Clas s=Asthma 20 conf:(1) 2495. Organism Attribute=female Organism Function=childbearing 20 ==> Disease-C lass=Asthma 20 conf:(1) 2496. Organism Attribute=females Research Activity=study 20 ==> Disease-Class=A sthma 20 conf:(1) 2497. Idea or Concept=predicted Human=subjects 20 ==> Disease-Class=Asthma 20 conf:(1) 2498. Idea or Concept=exception Finding=good health 20 ==> Disease-Class=Asthma 20 conf:(1) 2499. Research Activity=study Qualitative Concept=complete 20 ==> Disease-Class =Asthma 20 conf:(1) 2500. Research Activity=study Finding=lives 20 ==> Disease-Class=Asthma 20 c onf:(1) 2501. Research Activity=study Individual Behavior=conduct 20 ==> Disease-Class= Asthma 20 conf:(1) 2502. Qualitative Concept=other Therapeutic or Preventive Procedure=treatment 2 0 ==> Disease-Class=Asthma 20 conf:(1) 2503. Qualitative Concept=other Human=subjects 20 ==> Disease-Class=Asthma 20 conf:(1) 2504. Qualitative Concept=regular Activity=inhaled 20 ==> Disease-Class=Asthma 20 conf:(1) 2505. Qualitative Concept=significant Organization=laboratory 20 ==> Disease-Cl ass=Asthma 20 conf:(1) SYMBOL=- NUMERAL=??????2 20 ==> Disease-Class=Asthma 20 conf:(1) SYMBOL=- Mental or Behavioral Dysfunction=mdi 20 ==> Disease-Class=Asthma conf:(1) SYMBOL=- Immunologic Factor=ige 20 ==> Disease-Class=Asthma 20 conf:(1

2506. Qualitative Concept=beta2 Activity=inhaled 20 ==> Disease-Class=Asthma 20 conf:(1) 2507. Qualitative Concept=moderate to severe Disease or Syndrome=asthma 20 ==> Disease-Class=Asthma 20 conf:(1) 2508. Population Group=women Functional Concept=using 20 ==> Disease-Class=Asth ma 20 conf:(1) 2509. Population Group=legal guardian Family Group=parent 20 ==> Disease-Class= Asthma 20 conf:(1) 2510. Therapeutic or Preventive Procedure=treatment Disease or Syndrome=ics 20 ==> Disease-Class=Asthma 20 conf:(1) 2511. Therapeutic or Preventive Procedure=therapy Laboratory Procedure=screenin g 20 ==> Disease-Class=Asthma 20 conf:(1) 2512. Therapeutic or Preventive Procedure=ex Functional Concept=non 20 ==> Dise ase-Class=Asthma 20 conf:(1) 2513. Therapeutic or Preventive Procedure=ex Finding=smoking history 20 ==> Dis ease-Class=Asthma 20 conf:(1) 2514. Functional Concept=participate Human=subjects 20 ==> Disease-Class=Asthma 20 conf:(1) 2515. Functional Concept=use Disease or Syndrome=asthma 20 ==> Disease-Class=As thma 20 conf:(1) 2516. Functional Concept=used Disease or Syndrome=asthma 20 ==> Disease-Class=A sthma 20 conf:(1) 2517. Functional Concept=using Human=subject 20 ==> Disease-Class=Asthma 20 conf:(1) 2518. Spatial Concept=between Disease or Syndrome=asthma 20 ==> Disease-Class=A sthma 20 conf:(1) 2519. Spatial Concept=within Activity=taken 20 ==> Disease-Class=Asthma 20 c onf:(1) 2520. Spatial Concept=within Health Care Related Organization=hospital 20 ==> D isease-Class=Asthma 20 conf:(1) 2521. Spatial Concept=upper Disease or Syndrome=lower respiratory tract infecti on 20 ==> Disease-Class=Asthma 20 conf:(1) 2522. Spatial Concept=global Disease or Syndrome=asthma 20 ==> Disease-Class=As thma 20 conf:(1) 2523. Disease or Syndrome=asthma Physiologic Function=change in 20 ==> DiseaseClass=Asthma 20 conf:(1) 2524. Disease or Syndrome=asthma Mental Process=initiative 20 ==> Disease-Class =Asthma 20 conf:(1) 2525. Biologically Active Substance=leukotriene Activity=inhaled 20 ==> Disease -Class=Asthma 20 conf:(1) 2526. Professional or Occupational Group=investigator Mental Process=judgment 2 0 ==> Disease-Class=Asthma 20 conf:(1) 2527. Regulation or Law=informed consent Capacity=able to 20 ==> Disease-Class= Asthma 20 conf:(1) 2528. Patient or Disabled Group=patients Temporal Concept=prior to Laboratory P rocedure=screening 20 ==> Disease-Class=Asthma 20 conf:(1) 2529. Patient or Disabled Group=patient Idea or Concept=opinion Research Activi ty=study 20 ==> Disease-Class=Asthma 20 conf:(1) 2530. Patient or Disabled Group=patient Research Activity=study Activity=put 20 ==> Disease-Class=Asthma 20 conf:(1) 2531. Health Care Activity=hospitalization Disease or Syndrome=asthma Individua l Behavior=visit 20 ==> Disease-Class=Asthma 20 conf:(1) 2532. Temporal Concept=years NUMERAL=17.0 Idea or Concept=eligible 20 ==> Disea se-Class=Asthma 20 conf:(1) 2533. Temporal Concept=years NUMERAL=17.0 Age Group=ages 20 ==> Disease-Class=A sthma 20 conf:(1) 2534. Temporal Concept=years Quantitative Concept=pack Spatial Concept=within 2 0 ==> Disease-Class=Asthma 20 conf:(1) 2535. Temporal Concept=years Spatial Concept=between Age Group=age 20 ==> Disea se-Class=Asthma 20 conf:(1)

2536. Temporal Concept=after SYMBOL=- Diagnostic Procedure=fev1 20 ==> DiseaseClass=Asthma 20 conf:(1) 2537. Temporal Concept=prior to SYMBOL=>= NUMERAL=4.0 20 ==> Disease-Class=Asth ma 20 conf:(1) 2538. Temporal Concept=prior to NUMERAL=6.0 Disease or Syndrome=asthma 20 ==> D isease-Class=Asthma 20 conf:(1) 2539. Temporal Concept=prior to NUMERAL=30.0 Laboratory Procedure=screening 20 ==> Disease-Class=Asthma 20 conf:(1) 2540. Temporal Concept=prior to Quantitative Concept=exacerbation Spatial Conce pt=within 20 ==> Disease-Class=Asthma 20 conf:(1) 2541. Temporal Concept=prior to Functional Concept=use of Individual Behavior=v isit 20 ==> Disease-Class=Asthma 20 conf:(1) 2542. Temporal Concept=during SYMBOL=- Research Activity=study 20 ==> Disease-C lass=Asthma 20 conf:(1) 2543. Temporal Concept=weeks Pharmacologic Substance=corticosteroids Spatial Co ncept=within 20 ==> Disease-Class=Asthma 20 conf:(1) 2544. Temporal Concept=weeks NUMERAL=4.0 Quantitative Concept=exacerbation 20 = => Disease-Class=Asthma 20 conf:(1) 2545. Temporal Concept=weeks NUMERAL=4.0 Body Space or Junction=oral 20 ==> Dis ease-Class=Asthma 20 conf:(1) 2546. Temporal Concept=months Disease or Syndrome=asthma Body Space or Junction =oral 20 ==> Disease-Class=Asthma 20 conf:(1) 2547. Temporal Concept=period SYMBOL=- Laboratory Procedure=screening 20 ==> Di sease-Class=Asthma 20 conf:(1) 2548. Pharmacologic Substance=agonists Quantitative Concept=short Idea or Conce pt=acting 20 ==> Disease-Class=Asthma 20 conf:(1) 2549. Pharmacologic Substance=investigational drug NUMERAL=30.0 Spatial Concept =within 20 ==> Disease-Class=Asthma 20 conf:(1) 2550. Pharmacologic Substance=bronchodilator Idea or Concept=predicted Qualitat ive Concept=pre 20 ==> Disease-Class=Asthma 20 conf:(1) 2551. NO=not Research Activity=study Professional or Occupational Group=investi gator 20 ==> Disease-Class=Asthma 20 conf:(1) 2552. SYMBOL=- NUMERAL=6.0 Spatial Concept=within 20 ==> Disease-Class=Asthma 2 0 conf:(1) 2553. SYMBOL=- NUMERAL=2.0 Spatial Concept=within 20 ==> Disease-Class=Asthma 2 0 conf:(1) 2554. SYMBOL=- NUMERAL=2.0 Laboratory Procedure=screening 20 ==> Disease-Class= Asthma 20 conf:(1) 2555. SYMBOL=- NUMERAL=2.0 Individual Behavior=visit 20 ==> Disease-Class=Asthm a 20 conf:(1) 2556. SYMBOL=- Quantitative Concept=pack Behavior Problem=smoking 20 ==> Diseas e-Class=Asthma 20 conf:(1) 2557. SYMBOL=- Quantitative Concept=dose Research Activity=study 20 ==> Disease -Class=Asthma 20 conf:(1) 2558. SYMBOL=- Organism Attribute=female Human=subjects 20 ==> Disease-Class=As thma 20 conf:(1) 2559. SYMBOL=- Idea or Concept=acting Research Activity=study 20 ==> Disease-Cl ass=Asthma 20 conf:(1) 2560. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation 20 ==> Disease-Class=Asthma 20 conf:(1) 2561. SYMBOL=- Qualitative Concept=associated with Disease or Syndrome=asthma 2 0 ==> Disease-Class=Asthma 20 conf:(1) 2562. SYMBOL=- Therapeutic or Preventive Procedure=treatment Individual Behavio r=visit 20 ==> Disease-Class=Asthma 20 conf:(1) 2563. SYMBOL=- Therapeutic or Preventive Procedure=intubation Pathologic Functi on=hypoxic 20 ==> Disease-Class=Asthma 20 conf:(1) 2564. SYMBOL=- Therapeutic or Preventive Procedure=intubation Sign or Symptom=s eizures 20 ==> Disease-Class=Asthma 20 conf:(1) 2565. SYMBOL=- Therapeutic or Preventive Procedure=ex Behavior Problem=smokers 20 ==> Disease-Class=Asthma 20 conf:(1)

2566. SYMBOL=- Functional Concept=use of Activity=inhaled 20 ==> Disease-Class= Asthma 20 conf:(1) 2567. SYMBOL=- Functional Concept=use Individual Behavior=visit 20 ==> DiseaseClass=Asthma 20 conf:(1) 2568. SYMBOL=- Disease or Syndrome=asthma Sign or Symptom=seizures 20 ==> Disea se-Class=Asthma 20 conf:(1) 2569. SYMBOL=- Laboratory Procedure=screening Professional or Occupational Grou p=investigator 20 ==> Disease-Class=Asthma 20 conf:(1) 2570. SYMBOL=- Individual Behavior=visit Human=subject 20 ==> Disease-Class=Ast hma 20 conf:(1) 2571. SYMBOL=> NUMERAL=70.0 UNIT=% 20 ==> Disease-Class=Asthma 20 conf:(1) 2572. SYMBOL=>= UNIT=% Individual Behavior=visit 20 ==> Disease-Class=Asthma 20 conf:(1) 2573. SYMBOL=>= Idea or Concept=acting Activity=inhaled 20 ==> Disease-Class=As thma 20 conf:(1) 2574. SYMBOL=>= Laboratory Procedure=screening Human=subject 20 ==> Disease-Cla ss=Asthma 20 conf:(1) 2575. NUMERAL=5.0 Spatial Concept=within Finding=lives 20 ==> Disease-Class=Ast hma 20 conf:(1) 2576. NUMERAL=6.0 Spatial Concept=within Individual Behavior=visit 20 ==> Disea se-Class=Asthma 20 conf:(1) 2577. NUMERAL=3.0 Qualitative Concept=last Spatial Concept=within 20 ==> Diseas e-Class=Asthma 20 conf:(1) 2578. NUMERAL=3.0 Spatial Concept=within Body Space or Junction=oral 20 ==> Dis ease-Class=Asthma 20 conf:(1) 2579. NUMERAL=1.0 Quantitative Concept=exacerbation Spatial Concept=within 20 = => Disease-Class=Asthma 20 conf:(1) 2580. NUMERAL=85.0 UNIT=% Diagnostic Procedure=fev1 20 ==> Disease-Class=Asthma 20 conf:(1) 2581. Quantitative Concept=exacerbation Disease or Syndrome=asthma Laboratory P rocedure=screening 20 ==> Disease-Class=Asthma 20 conf:(1) 2582. UNIT=% Idea or Concept=predicted Spatial Concept=between 20 ==> Disease-C lass=Asthma 20 conf:(1) 2583. UNIT=% Spatial Concept=within Organism Function=inhalation 20 ==> Disease -Class=Asthma 20 conf:(1) 2584. Idea or Concept=predicted Spatial Concept=between Diagnostic Procedure=fe v1 20 ==> Disease-Class=Asthma 20 conf:(1) 2585. Idea or Concept=opinion Research Activity=study Activity=put 20 ==> Disea se-Class=Asthma 20 conf:(1) 2586. Research Activity=study Therapeutic or Preventive Procedure=procedures Co mpliance=comply 20 ==> Disease-Class=Asthma 20 conf:(1) 2587. Research Activity=study Spatial Concept=within Body Space or Junction=ora l 20 ==> Disease-Class=Asthma 20 conf:(1) 2588. Research Activity=study Activity=put Individual Behavior=participation 20 ==> Disease-Class=Asthma 20 conf:(1) 2589. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Disease or Syndrome=asthma 20 ==> Disease-Class=Asthma 20 conf:(1) 2590. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Finding=life 20 ==> Disease-Class=Asthma 20 conf:(1) 2591. Qualitative Concept=associated with Disease or Syndrome=asthma Finding=li fe 20 ==> Disease-Class=Asthma 20 conf:(1) 2592. Qualitative Concept=from Laboratory Procedure=screening Individual Behavi or=visit 20 ==> Disease-Class=Asthma 20 conf:(1) 2593. Therapeutic or Preventive Procedure=treatment Functional Concept=requirin g Disease or Syndrome=asthma 20 ==> Disease-Class=Asthma 20 conf:(1) 2594. Therapeutic or Preventive Procedure=treatment Spatial Concept=within Acti vity=inhaled 20 ==> Disease-Class=Asthma 20 conf:(1) 2595. Therapeutic or Preventive Procedure=intubation Pathologic Function=hypoxi c Finding=life 20 ==> Disease-Class=Asthma 20 conf:(1) 2596. Therapeutic or Preventive Procedure=intubation Finding=life Sign or Sympt

om=seizures 20 ==> Disease-Class=Asthma 20 conf:(1) 2597. Functional Concept=use of Activity=inhaled Body Space or Junction=oral 20 ==> Disease-Class=Asthma 20 conf:(1) 2598. Functional Concept=participate Professional or Occupational Group=investi gator Capacity=ability 20 ==> Disease-Class=Asthma 20 conf:(1) 2599. Spatial Concept=within Disease or Syndrome=asthma Finding=life 20 ==> Dis ease-Class=Asthma 20 conf:(1) 2600. Spatial Concept=global Disease or Syndrome=asthma Mental Process=initiati ve 20 ==> Disease-Class=Asthma 20 conf:(1) 2601. Disease or Syndrome=asthma Laboratory Procedure=screening Human=subject 2 0 ==> Disease-Class=Asthma 20 conf:(1) 2602. Disease or Syndrome=asthma Finding=life Sign or Symptom=seizures 20 ==> D isease-Class=Asthma 20 conf:(1) 2603. Temporal Concept=years SYMBOL=- NUMERAL=10.0 Spatial Concept=within 20 == > Disease-Class=Asthma 20 conf:(1) 2604. Temporal Concept=years SYMBOL=- Quantitative Concept=pack Spatial Concept =within 20 ==> Disease-Class=Asthma 20 conf:(1) 2605. Pharmacologic Substance=corticosteroids Spatial Concept=within Laboratory Procedure=screening Body Space or Junction=oral 20 ==> Disease-Class=Asthma 20 conf:(1) 2606. Pharmacologic Substance=bronchodilator SYMBOL=- UNIT=% Diagnostic Procedu re=fev1 20 ==> Disease-Class=Asthma 20 conf:(1) 2607. Pharmacologic Substance=bronchodilator UNIT=% Idea or Concept=predicted Q ualitative Concept=pre 20 ==> Disease-Class=Asthma 20 conf:(1) 2608. NO=not SYMBOL=- Research Activity=study Human=subject 20 ==> Disease-Clas s=Asthma 20 conf:(1) 2609. SYMBOL=- UNIT=% Diagnostic Procedure=fev1 Individual Behavior=visit 20 == > Disease-Class=Asthma 20 conf:(1) 2610. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Finding=life 20 ==> Disease-Class=Asthma 20 conf:(1) 2611. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Sign or Symptom=seizures 20 ==> Disease-Class=Asthma 20 co nf:(1) 2612. SYMBOL=- Qualitative Concept=associated with Disease or Syndrome=asthma F inding=life 20 ==> Disease-Class=Asthma 20 conf:(1) 2613. SYMBOL=- Qualitative Concept=associated with Disease or Syndrome=asthma S ign or Symptom=seizures 20 ==> Disease-Class=Asthma 20 conf:(1) 2614. SYMBOL=- Therapeutic or Preventive Procedure=intubation Pathologic Functi on=hypoxic Disease or Syndrome=asthma 20 ==> Disease-Class=Asthma 20 conf:(1) 2615. SYMBOL=- Therapeutic or Preventive Procedure=intubation Pathologic Functi on=hypoxic Finding=life 20 ==> Disease-Class=Asthma 20 conf:(1) 2616. SYMBOL=- Therapeutic or Preventive Procedure=intubation Finding=life Sign or Symptom=seizures 20 ==> Disease-Class=Asthma 20 conf:(1) 2617. SYMBOL=- Disease or Syndrome=asthma Finding=life Sign or Symptom=seizures 20 ==> Disease-Class=Asthma 20 conf:(1) 2618. NUMERAL=1.0 UNIT=% Diagnostic Procedure=fev1 Individual Behavior=visit 20 ==> Disease-Class=Asthma 20 conf:(1) 2619. UNIT=% Idea or Concept=predicted Laboratory Procedure=screening Individua l Behavior=visit 20 ==> Disease-Class=Asthma 20 conf:(1) 2620. Idea or Concept=opinion Research Activity=study Professional or Occupatio nal Group=investigator Activity=put 20 ==> Disease-Class=Asthma 20 conf:(1) 2621. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Disease or Syndrome=asthma Sign or Symptom=seizures 20 ==> Disease-Cla ss=Asthma 20 conf:(1) 2622. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Finding=life Sign or Symptom=seizures 20 ==> Disease-Class=Asthma 20 conf:(1) 2623. Qualitative Concept=associated with Disease or Syndrome=asthma Finding=li fe Sign or Symptom=seizures 20 ==> Disease-Class=Asthma 20 conf:(1) 2624. Therapeutic or Preventive Procedure=intubation Pathologic Function=hypoxi

c Disease or Syndrome=asthma Finding=life 20 ==> Disease-Class=Asthma 20 conf :(1) 2625. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Finding=life Sign or Symptom=seizures 20 ==> Disease-Class=As thma 20 conf:(1) 2626. SYMBOL=- Qualitative Concept=associated with Disease or Syndrome=asthma F inding=life Sign or Symptom=seizures 20 ==> Disease-Class=Asthma 20 conf:(1) 2627. SYMBOL=- Therapeutic or Preventive Procedure=intubation Pathologic Functi on=hypoxic Disease or Syndrome=asthma Finding=life 20 ==> Disease-Class=Asthma 2 0 conf:(1) 2628. Health Care Activity=enrolment 19 ==> Disease-Class=Asthma 19 conf:(1) 2629. Intellectual Product=interpretation 19 ==> Disease-Class=Asthma 19 con f:(1) 2630. Clinical Attribute=height 19 ==> Disease-Class=Asthma 19 conf:(1) 2631. Pharmacologic Substance=prednisone 19 ==> Disease-Class=Asthma 19 conf :(1) 2632. Pharmacologic Substance=budesonide 19 ==> Disease-Class=Asthma 19 conf :(1) 2633. NO=excluding 19 ==> Disease-Class=Asthma 19 conf:(1) 2634. Idea or Concept=admitted 19 ==> Disease-Class=Asthma 19 conf:(1) 2635. Qualitative Concept=improvement 19 ==> Disease-Class=Asthma 19 conf:(1 ) 2636. Qualitative Concept=adequate 19 ==> Disease-Class=Asthma 19 conf:(1) 2637. Gene or Genome=her 19 ==> Disease-Class=Asthma 19 conf:(1) 2638. Functional Concept=evidence 19 ==> Disease-Class=Asthma 19 conf:(1) 2639. Functional Concept=provided 19 ==> Disease-Class=Asthma 19 conf:(1) 2640. Functional Concept=neurologic 19 ==> Disease-Class=Asthma 19 conf:(1) 2641. Functional Concept=participated 19 ==> Disease-Class=Asthma 19 conf:(1 ) 2642. Spatial Concept=part 19 ==> Disease-Class=Asthma 19 conf:(1) 2643. Organism Function=postmenopausal 19 ==> Disease-Class=Asthma 19 conf:( 1) 2644. Disease or Syndrome=hypertension 19 ==> Disease-Class=Asthma 19 conf:( 1) 2645. Receptor=er 19 ==> Disease-Class=Asthma 19 conf:(1) 2646. Finding=prick 19 ==> Disease-Class=Asthma 19 conf:(1) 2647. Biologically Active Substance=components 19 ==> Disease-Class=Asthma 19 conf:(1) 2648. Organization=home 19 ==> Disease-Class=Asthma 19 conf:(1) 2649. Willing=unwillingness 19 ==> Disease-Class=Asthma 19 conf:(1) 2650. Behavior Problem=substance abuse 19 ==> Disease-Class=Asthma 19 conf:( 1) 2651. Patient or Disabled Group=patient Temporal Concept=history of 19 ==> Dise ase-Class=Asthma 19 conf:(1) 2652. Patient or Disabled Group=patient Individual Behavior=participation 19 == > Disease-Class=Asthma 19 conf:(1) 2653. Health Care Activity=diagnosis Disease or Syndrome=copd 19 ==> Disease-Cl ass=Asthma 19 conf:(1) 2654. Health Care Activity=diagnosis Sign or Symptom=symptoms 19 ==> Disease-Cl ass=Asthma 19 conf:(1) 2655. Health Care Activity=hospitalization Human=subject 19 ==> Disease-Class=A sthma 19 conf:(1) 2656. Temporal Concept=years Therapeutic or Preventive Procedure=ex 19 ==> Dise ase-Class=Asthma 19 conf:(1) 2657. Temporal Concept=years Functional Concept=non 19 ==> Disease-Class=Asthma 19 conf:(1) 2658. Temporal Concept=years Individual Behavior=visit 19 ==> Disease-Class=Ast hma 19 conf:(1) 2659. Temporal Concept=years Behavior Problem=smoked 19 ==> Disease-Class=Asthm a 19 conf:(1)

2660. Temporal Concept=days SYMBOL=> 19 ==> Disease-Class=Asthma 19 conf:(1) 2661. Temporal Concept=history of Professional or Occupational Group=investigat or 19 ==> Disease-Class=Asthma 19 conf:(1) 2662. Temporal Concept=history of Human=subjects 19 ==> Disease-Class=Asthma 19 conf:(1) 2663. Temporal Concept=after SYMBOL=>= 19 ==> Disease-Class=Asthma 19 conf:( 1) 2664. Temporal Concept=prior to UNIT=% 19 ==> Disease-Class=Asthma 19 conf:( 1) 2665. Temporal Concept=prior to Activity=taken 19 ==> Disease-Class=Asthma 19 conf:(1) 2666. Temporal Concept=during Disease or Syndrome=asthma 19 ==> Disease-Class=A sthma 19 conf:(1) 2667. Temporal Concept=weeks NUMERAL=12.0 19 ==> Disease-Class=Asthma 19 con f:(1) 2668. Temporal Concept=weeks NUMERAL=8.0 19 ==> Disease-Class=Asthma 19 conf :(1) 2669. Temporal Concept=months Quantitative Concept=exacerbation 19 ==> DiseaseClass=Asthma 19 conf:(1) 2670. Temporal Concept=period Quantitative Concept=baseline 19 ==> Disease-Clas s=Asthma 19 conf:(1) 2671. Temporal Concept=before Therapeutic or Preventive Procedure=treatment 19 ==> Disease-Class=Asthma 19 conf:(1) 2672. Temporal Concept=reversibility Diagnostic Procedure=fev1 19 ==> Disease-C lass=Asthma 19 conf:(1) 2673. Temporal Concept=hours SYMBOL=- 19 ==> Disease-Class=Asthma 19 conf:(1 ) 2674. Temporal Concept=concomitant Disease or Syndrome=diseases 19 ==> DiseaseClass=Asthma 19 conf:(1) 2675. Intellectual Product=methods Research Activity=study 19 ==> Disease-Class =Asthma 19 conf:(1) 2676. Intellectual Product=criteria NO=not 19 ==> Disease-Class=Asthma 19 co nf:(1) 2677. Intellectual Product=pack years NUMERAL=5.0 19 ==> Disease-Class=Asthma 1 9 conf:(1) 2678. Intellectual Product=method NO=not 19 ==> Disease-Class=Asthma 19 conf :(1) 2679. Intellectual Product=method SYMBOL=- 19 ==> Disease-Class=Asthma 19 co nf:(1) 2680. Intellectual Product=method Organism Function=childbearing 19 ==> Disease -Class=Asthma 19 conf:(1) 2681. Pharmacologic Substance=albuterol Spatial Concept=within 19 ==> Disease-C lass=Asthma 19 conf:(1) 2682. Pharmacologic Substance=drug abuse Spatial Concept=within 19 ==> DiseaseClass=Asthma 19 conf:(1) 2683. Pharmacologic Substance=medication Functional Concept=use of 19 ==> Disea se-Class=Asthma 19 conf:(1) 2684. Pharmacologic Substance=medication Human=subjects 19 ==> Disease-Class=As thma 19 conf:(1) 2685. Pharmacologic Substance=agonist Functional Concept=use of 19 ==> DiseaseClass=Asthma 19 conf:(1) 2686. Pharmacologic Substance=bronchodilator SYMBOL=>= 19 ==> Disease-Class=Ast hma 19 conf:(1) 2687. Pharmacologic Substance=bronchodilator Idea or Concept=acting 19 ==> Dise ase-Class=Asthma 19 conf:(1) 2688. Pharmacologic Substance=blockers SYMBOL=- 19 ==> Disease-Class=Asthma 19 conf:(1) 2689. NO=not Functional Concept=used 19 ==> Disease-Class=Asthma 19 conf:(1) 2690. SYMBOL=- Quantitative Concept=equivalent 19 ==> Disease-Class=Asthma 19 conf:(1)

2691. SYMBOL=- Quantitative Concept=all 19 ==> Disease-Class=Asthma 19 conf: (1) 2692. SYMBOL=- Quantitative Concept=kg 19 ==> Disease-Class=Asthma 19 conf:( 1) 2693. SYMBOL=- Functional Concept=controlled 19 ==> Disease-Class=Asthma 19 conf:(1) 2694. SYMBOL=- Organism Function=pregnancy 19 ==> Disease-Class=Asthma 19 co nf:(1) 2695. SYMBOL=- Disease or Syndrome=disease 19 ==> Disease-Class=Asthma 19 co nf:(1) 2696. SYMBOL=- Laboratory Procedure=test 19 ==> Disease-Class=Asthma 19 conf :(1) 2697. SYMBOL=- Diagnostic Procedure=ecg 19 ==> Disease-Class=Asthma 19 conf: (1) 2698. SYMBOL=- Activity=interfere 19 ==> Disease-Class=Asthma 19 conf:(1) 2699. SYMBOL=- Individual Behavior=participation 19 ==> Disease-Class=Asthma 19 conf:(1) 2700. SYMBOL=> Body Space or Junction=oral 19 ==> Disease-Class=Asthma 19 co nf:(1) 2701. SYMBOL=< NUMERAL=80.0 19 ==> Disease-Class=Asthma 19 conf:(1) 2702. SYMBOL=< Functional Concept=non 19 ==> Disease-Class=Asthma 19 conf:(1 ) 2703. SYMBOL=< Age Group=age 19 ==> Disease-Class=Asthma 19 conf:(1) 2704. SYMBOL=< Sign or Symptom=symptoms 19 ==> Disease-Class=Asthma 19 conf: (1) 2705. NUMERAL=10.0 Behavior Problem=smoked 19 ==> Disease-Class=Asthma 19 co nf:(1) 2706. NUMERAL=10.0 Behavior Problem=smoker 19 ==> Disease-Class=Asthma 19 co nf:(1) 2707. NUMERAL=1.0 Idea or Concept=acting 19 ==> Disease-Class=Asthma 19 conf :(1) 2708. NUMERAL=15.0 Research Activity=study 19 ==> Disease-Class=Asthma 19 co nf:(1) 2709. NUMERAL=14.0 Age Group=ages 19 ==> Disease-Class=Asthma 19 conf:(1) 2710. NUMERAL=17.0 Research Activity=study 19 ==> Disease-Class=Asthma 19 co nf:(1) 2711. NUMERAL=??????2 Idea or Concept=acting 19 ==> Disease-Class=Asthma 19 conf:(1) 2712. Quantitative Concept=one Human=subject 19 ==> Disease-Class=Asthma 19 conf:(1) 2713. Quantitative Concept=baseline Therapeutic or Preventive Procedure=treatme nt 19 ==> Disease-Class=Asthma 19 conf:(1) 2714. Quantitative Concept=short Functional Concept=use of 19 ==> Disease-Class =Asthma 19 conf:(1) 2715. Quantitative Concept=mcg UNIT=% 19 ==> Disease-Class=Asthma 19 conf:(1 ) 2716. Quantitative Concept=puffs UNIT=% 19 ==> Disease-Class=Asthma 19 conf: (1) 2717. Quantitative Concept=normal value Idea or Concept=predicted 19 ==> Diseas e-Class=Asthma 19 conf:(1) 2718. Organism Attribute=females Body Substance=serum 19 ==> Disease-Class=Asth ma 19 conf:(1) 2719. Idea or Concept=requirements Research Activity=study 19 ==> Disease-Class =Asthma 19 conf:(1) 2720. Research Activity=study Professional or Occupational Group=physician 19 = => Disease-Class=Asthma 19 conf:(1) 2721. Research Activity=study Sign or Symptom=run 19 ==> Disease-Class=Asthma 1 9 conf:(1) 2722. Research Activity=study Activity=receipt 19 ==> Disease-Class=Asthma 19 conf:(1)

2723. Research Activity=study Behavior Problem=abstinence 19 ==> Disease-Class= Asthma 19 conf:(1) 2724. Research Activity=randomization Disease or Syndrome=asthma 19 ==> Disease -Class=Asthma 19 conf:(1) 2725. Qualitative Concept=associated with Pathologic Function=hypoxic 19 ==> Di sease-Class=Asthma 19 conf:(1) 2726. Qualitative Concept=last Laboratory Procedure=screening 19 ==> Disease-Cl ass=Asthma 19 conf:(1) 2727. Qualitative Concept=significant Disease or Syndrome=abnormality 19 ==> Di sease-Class=Asthma 19 conf:(1) 2728. Qualitative Concept=significant Human=subject 19 ==> Disease-Class=Asthma 19 conf:(1) 2729. Qualitative Concept=acceptable Laboratory Procedure=screening 19 ==> Dise ase-Class=Asthma 19 conf:(1) 2730. Population Group=women Contraception=birth control 19 ==> Disease-Class=A sthma 19 conf:(1) 2731. Therapeutic or Preventive Procedure=treatment Functional Concept=includin g 19 ==> Disease-Class=Asthma 19 conf:(1) 2732. Therapeutic or Preventive Procedure=therapy Manufactured Object=controlle r 19 ==> Disease-Class=Asthma 19 conf:(1) 2733. Therapeutic or Preventive Procedure=administration Diagnostic Procedure=f ev1 19 ==> Disease-Class=Asthma 19 conf:(1) 2734. Functional Concept=evidence of Human=subject 19 ==> Disease-Class=Asthma 19 conf:(1) 2735. Functional Concept=non Finding=smoking history 19 ==> Disease-Class=Asthm a 19 conf:(1) 2736. Functional Concept=non Human=subjects 19 ==> Disease-Class=Asthma 19 c onf:(1) 2737. Functional Concept=use Willing=agree 19 ==> Disease-Class=Asthma 19 co nf:(1) 2738. Functional Concept=increase Spatial Concept=within 19 ==> Disease-Class=A sthma 19 conf:(1) 2739. Functional Concept=increase Laboratory Procedure=screening 19 ==> Disease -Class=Asthma 19 conf:(1) 2740. Functional Concept=start Disease or Syndrome=asthma 19 ==> Disease-Class= Asthma 19 conf:(1) 2741. Spatial Concept=within Sign or Symptom=run 19 ==> Disease-Class=Asthma 19 conf:(1) 2742. Spatial Concept=within Activity=receipt 19 ==> Disease-Class=Asthma 19 conf:(1) 2743. Pathologic Function=hypoxic Sign or Symptom=seizures 19 ==> Disease-Class =Asthma 19 conf:(1) 2744. Pathologic Function=obstruction Physiologic Function=airflow 19 ==> Disea se-Class=Asthma 19 conf:(1) 2745. Disease or Syndrome=ics Manufactured Object=controller 19 ==> Disease-Cla ss=Asthma 19 conf:(1) 2746. Laboratory Procedure=screening Diagnostic Procedure=ecg 19 ==> Disease-Cl ass=Asthma 19 conf:(1) 2747. Biologically Active Substance=leukotriene Chemical Viewed Functionally=mo difiers 19 ==> Disease-Class=Asthma 19 conf:(1) 2748. Age Group=age Diagnostic Procedure=fev1 19 ==> Disease-Class=Asthma 19 conf:(1) 2749. Age Group=age Human=subjects 19 ==> Disease-Class=Asthma 19 conf:(1) 2750. Regulation or Law=informed consent Family Group=parent 19 ==> Disease-Cla ss=Asthma 19 conf:(1) 2751. Individual Behavior=visit Capacity=able to 19 ==> Disease-Class=Asthma 19 conf:(1) 2752. Patient or Disabled Group=patients SYMBOL=- Individual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2753. Patient or Disabled Group=patient Research Activity=study Individual Beha

vior=participation 19 ==> Disease-Class=Asthma 19 conf:(1) 2754. Health Care Activity=documented UNIT=% Spatial Concept=within 19 ==> Dise ase-Class=Asthma 19 conf:(1) 2755. Health Care Activity=documented UNIT=% Laboratory Procedure=screening 19 ==> Disease-Class=Asthma 19 conf:(1) 2756. Temporal Concept=years SYMBOL=>= Age Group=age 19 ==> Disease-Class=Asthm a 19 conf:(1) 2757. Temporal Concept=years NUMERAL=17.0 Research Activity=study 19 ==> Diseas e-Class=Asthma 19 conf:(1) 2758. Temporal Concept=prior to SYMBOL=- Human=subject 19 ==> Disease-Class=Ast hma 19 conf:(1) 2759. Temporal Concept=prior to SYMBOL=>= Research Activity=study 19 ==> Diseas e-Class=Asthma 19 conf:(1) 2760. Temporal Concept=prior to SYMBOL=>= Functional Concept=use of 19 ==> Dise ase-Class=Asthma 19 conf:(1) 2761. Temporal Concept=prior to Quantitative Concept=one Spatial Concept=within 19 ==> Disease-Class=Asthma 19 conf:(1) 2762. Temporal Concept=prior to Individual Behavior=visit Human=subject 19 ==> Disease-Class=Asthma 19 conf:(1) 2763. Temporal Concept=weeks Research Activity=study Spatial Concept=within 19 ==> Disease-Class=Asthma 19 conf:(1) 2764. Temporal Concept=weeks Functional Concept=use of Spatial Concept=within 1 9 ==> Disease-Class=Asthma 19 conf:(1) 2765. Temporal Concept=weeks Activity=inhaled Body Space or Junction=oral 19 == > Disease-Class=Asthma 19 conf:(1) 2766. Temporal Concept=weeks Body Space or Junction=oral Individual Behavior=vi sit 19 ==> Disease-Class=Asthma 19 conf:(1) 2767. Temporal Concept=year SYMBOL=>= NUMERAL=1.0 19 ==> Disease-Class=Asthma 1 9 conf:(1) 2768. Temporal Concept=period SYMBOL=- Spatial Concept=within 19 ==> Disease-Cl ass=Asthma 19 conf:(1) 2769. Temporal Concept=before NUMERAL=1.0 Spatial Concept=within 19 ==> Disease -Class=Asthma 19 conf:(1) 2770. Temporal Concept=before Research Activity=study Spatial Concept=within 19 ==> Disease-Class=Asthma 19 conf:(1) 2771. Temporal Concept=reversibility UNIT=% Diagnostic Procedure=fev1 19 ==> Di sease-Class=Asthma 19 conf:(1) 2772. Temporal Concept=post UNIT=% Diagnostic Procedure=fev1 19 ==> Disease-Cla ss=Asthma 19 conf:(1) 2773. Intellectual Product=pack years NUMERAL=10.0 Behavior Problem=smokers 19 ==> Disease-Class=Asthma 19 conf:(1) 2774. Intellectual Product=method Research Activity=study Willing=agree 19 ==> Disease-Class=Asthma 19 conf:(1) 2775. Pharmacologic Substance=medication Laboratory Procedure=screening Individ ual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2776. Pharmacologic Substance=corticosteroids Functional Concept=use of Spatial Concept=within 19 ==> Disease-Class=Asthma 19 conf:(1) 2777. Pharmacologic Substance=corticosteroids Functional Concept=systemic Spati al Concept=within 19 ==> Disease-Class=Asthma 19 conf:(1) 2778. Pharmacologic Substance=corticosteroids Spatial Concept=within Disease or Syndrome=asthma 19 ==> Disease-Class=Asthma 19 conf:(1) 2779. NO=not SYMBOL=- NUMERAL=1.0 19 ==> Disease-Class=Asthma 19 conf:(1) 2780. NO=not Research Activity=study Spatial Concept=within 19 ==> Disease-Clas s=Asthma 19 conf:(1) 2781. NO=not Research Activity=study Disease or Syndrome=asthma 19 ==> DiseaseClass=Asthma 19 conf:(1) 2782. NO=not Disease or Syndrome=asthma Individual Behavior=visit 19 ==> Diseas e-Class=Asthma 19 conf:(1) 2783. SYMBOL=- NUMERAL=5.0 Finding=lives 19 ==> Disease-Class=Asthma 19 conf :(1)

2784. SYMBOL=- NUMERAL=4.0 Laboratory Procedure=screening 19 ==> Disease-Class= Asthma 19 conf:(1) 2785. SYMBOL=- UNIT=% Disease or Syndrome=asthma 19 ==> Disease-Class=Asthma 19 conf:(1) 2786. SYMBOL=- Idea or Concept=acting Functional Concept=use 19 ==> Disease-Cla ss=Asthma 19 conf:(1) 2787. SYMBOL=- Idea or Concept=opinion Research Activity=study 19 ==> Disease-C lass=Asthma 19 conf:(1) 2788. SYMBOL=- Research Activity=study Therapeutic or Preventive Procedure=proc edures 19 ==> Disease-Class=Asthma 19 conf:(1) 2789. SYMBOL=- Qualitative Concept=beta Therapeutic or Preventive Procedure=tre atment 19 ==> Disease-Class=Asthma 19 conf:(1) 2790. SYMBOL=- Qualitative Concept=beta Functional Concept=use of 19 ==> Diseas e-Class=Asthma 19 conf:(1) 2791. SYMBOL=- Qualitative Concept=related Disease or Syndrome=asthma 19 ==> Di sease-Class=Asthma 19 conf:(1) 2792. SYMBOL=- Therapeutic or Preventive Procedure=treatment Spatial Concept=wi thin 19 ==> Disease-Class=Asthma 19 conf:(1) 2793. SYMBOL=- Functional Concept=increase Diagnostic Procedure=fev1 19 ==> Dis ease-Class=Asthma 19 conf:(1) 2794. SYMBOL=- Spatial Concept=within Sign or Symptom=run 19 ==> Disease-Class= Asthma 19 conf:(1) 2795. SYMBOL=- Body Space or Junction=oral Individual Behavior=visit 19 ==> Dis ease-Class=Asthma 19 conf:(1) 2796. SYMBOL=> Laboratory Procedure=screening Diagnostic Procedure=fev1 19 ==> Disease-Class=Asthma 19 conf:(1) 2797. SYMBOL=< NUMERAL=80.0 UNIT=% 19 ==> Disease-Class=Asthma 19 conf:(1) 2798. SYMBOL=< Laboratory or Test Result=pc20 Organic Chemical=methacholine 19 ==> Disease-Class=Asthma 19 conf:(1) 2799. SYMBOL=>= Disease or Syndrome=ics Laboratory Procedure=screening 19 ==> D isease-Class=Asthma 19 conf:(1) 2800. NUMERAL=5.0 Research Activity=study Spatial Concept=within 19 ==> Disease -Class=Asthma 19 conf:(1) 2801. NUMERAL=6.0 Spatial Concept=within Laboratory Procedure=screening 19 ==> Disease-Class=Asthma 19 conf:(1) 2802. NUMERAL=3.0 Spatial Concept=within Individual Behavior=visit 19 ==> Disea se-Class=Asthma 19 conf:(1) 2803. NUMERAL=1.0 Quantitative Concept=exacerbation Disease or Syndrome=asthma 19 ==> Disease-Class=Asthma 19 conf:(1) 2804. NUMERAL=1.0 Functional Concept=use of Spatial Concept=within 19 ==> Disea se-Class=Asthma 19 conf:(1) 2805. NUMERAL=1.0 Laboratory Procedure=screening Human=subject 19 ==> Disease-C lass=Asthma 19 conf:(1) 2806. NUMERAL=12.0 Research Activity=study Spatial Concept=within 19 ==> Diseas e-Class=Asthma 19 conf:(1) 2807. NUMERAL=17.0 Idea or Concept=eligible Research Activity=study 19 ==> Dise ase-Class=Asthma 19 conf:(1) 2808. NUMERAL=17.0 Idea or Concept=eligible Age Group=ages 19 ==> Disease-Class =Asthma 19 conf:(1) 2809. NUMERAL=17.0 Research Activity=study Age Group=ages 19 ==> Disease-Class= Asthma 19 conf:(1) 2810. Quantitative Concept=baseline UNIT=% Laboratory Procedure=screening 19 == > Disease-Class=Asthma 19 conf:(1) 2811. Quantitative Concept=baseline Laboratory Procedure=screening Diagnostic P rocedure=fev1 19 ==> Disease-Class=Asthma 19 conf:(1) 2812. Quantitative Concept=normal value UNIT=% Idea or Concept=predicted 19 ==> Disease-Class=Asthma 19 conf:(1) 2813. UNIT=% Functional Concept=increase Individual Behavior=visit 19 ==> Disea se-Class=Asthma 19 conf:(1) 2814. UNIT=% Spatial Concept=within Individual Behavior=visit 19 ==> Disease-Cl

ass=Asthma 19 conf:(1) 2815. Organism Attribute=female Idea or Concept=eligible Research Activity=stud y 19 ==> Disease-Class=Asthma 19 conf:(1) 2816. Idea or Concept=acting Qualitative Concept=long Activity=inhaled 19 ==> D isease-Class=Asthma 19 conf:(1) 2817. Idea or Concept=acting Laboratory Procedure=screening Individual Behavior =visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2818. Idea or Concept=acting Activity=inhaled Individual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2819. Idea or Concept=opinion Research Activity=study Human-caused Phenomenon o r Process=safety 19 ==> Disease-Class=Asthma 19 conf:(1) 2820. Research Activity=study Qualitative Concept=at risk Activity=put 19 ==> D isease-Class=Asthma 19 conf:(1) 2821. Research Activity=study Individual Behavior=visit Human=subject 19 ==> Di sease-Class=Asthma 19 conf:(1) 2822. Research Activity=gina Disease or Syndrome=asthma Social Behavior=accordi ng 19 ==> Disease-Class=Asthma 19 conf:(1) 2823. Qualitative Concept=negative Organism Function=pregnancy test Body Substa nce=serum 19 ==> Disease-Class=Asthma 19 conf:(1) 2824. Qualitative Concept=associated with Pathologic Function=hypoxic Disease o r Syndrome=asthma 19 ==> Disease-Class=Asthma 19 conf:(1) 2825. Qualitative Concept=associated with Pathologic Function=hypoxic Sign or S ymptom=seizures 19 ==> Disease-Class=Asthma 19 conf:(1) 2826. Therapeutic or Preventive Procedure=treatment Spatial Concept=within Labo ratory Procedure=screening 19 ==> Disease-Class=Asthma 19 conf:(1) 2827. Therapeutic or Preventive Procedure=treatment Spatial Concept=within Body Space or Junction=oral 19 ==> Disease-Class=Asthma 19 conf:(1) 2828. Therapeutic or Preventive Procedure=treatment Body Space or Junction=oral Individual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2829. Functional Concept=systemic Spatial Concept=within Individual Behavior=vi sit 19 ==> Disease-Class=Asthma 19 conf:(1) 2830. Spatial Concept=within Laboratory Procedure=screening Diagnostic Procedur e=fev1 19 ==> Disease-Class=Asthma 19 conf:(1) 2831. Pathologic Function=hypoxic Disease or Syndrome=asthma Sign or Symptom=se izures 19 ==> Disease-Class=Asthma 19 conf:(1) 2832. Health Care Activity=diagnosis Temporal Concept=months SYMBOL=>= Disease or Syndrome=asthma 19 ==> Disease-Class=Asthma 19 conf:(1) 2833. Temporal Concept=years NUMERAL=10.0 Quantitative Concept=pack Spatial Con cept=within 19 ==> Disease-Class=Asthma 19 conf:(1) 2834. Temporal Concept=years NUMERAL=17.0 Idea or Concept=eligible Research Act ivity=study 19 ==> Disease-Class=Asthma 19 conf:(1) 2835. Temporal Concept=years NUMERAL=17.0 Idea or Concept=eligible Age Group=ag es 19 ==> Disease-Class=Asthma 19 conf:(1) 2836. Temporal Concept=years NUMERAL=17.0 Research Activity=study Age Group=age s 19 ==> Disease-Class=Asthma 19 conf:(1) 2837. Temporal Concept=weeks Spatial Concept=within Body Space or Junction=oral Individual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2838. Pharmacologic Substance=bronchodilator Idea or Concept=predicted Qualitat ive Concept=pre Diagnostic Procedure=fev1 19 ==> Disease-Class=Asthma 19 conf :(1) 2839. SYMBOL=- UNIT=% Laboratory Procedure=screening Individual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2840. SYMBOL=- Idea or Concept=acting Qualitative Concept=beta Activity=inhaled 19 ==> Disease-Class=Asthma 19 conf:(1) 2841. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Disease or Syndrome=asthma 19 ==> Disease-Class=Asthma 19 conf:(1) 2842. SYMBOL=- Therapeutic or Preventive Procedure=intubation Disease or Syndro me=asthma Sign or Symptom=seizures 19 ==> Disease-Class=Asthma 19 conf:(1) 2843. SYMBOL=- Spatial Concept=within Disease or Syndrome=asthma Finding=life 1

9 ==> Disease-Class=Asthma 19 conf:(1) 2844. NUMERAL=4.0 Spatial Concept=within Laboratory Procedure=screening Individ ual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2845. NUMERAL=1.0 Therapeutic or Preventive Procedure=treatment Spatial Concept =within Individual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf:(1) 2846. NUMERAL=1.0 Spatial Concept=within Disease or Syndrome=asthma Laboratory Procedure=screening 19 ==> Disease-Class=Asthma 19 conf:(1) 2847. NUMERAL=17.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 19 ==> Disease-Class=Asthma 19 conf:(1) 2848. UNIT=% Idea or Concept=predicted Spatial Concept=between Diagnostic Proce dure=fev1 19 ==> Disease-Class=Asthma 19 conf:(1) 2849. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Disease or Syndrome=asthma Finding=life 19 ==> Disease-Class=Asthma 19 conf:(1) 2850. Qualitative Concept=associated with Pathologic Function=hypoxic Disease o r Syndrome=asthma Sign or Symptom=seizures 19 ==> Disease-Class=Asthma 19 con f:(1) 2851. Therapeutic or Preventive Procedure=intubation Disease or Syndrome=asthma Finding=life Sign or Symptom=seizures 19 ==> Disease-Class=Asthma 19 conf:(1 ) 2852. Temporal Concept=years SYMBOL=- NUMERAL=10.0 Quantitative Concept=pack Sp atial Concept=within 19 ==> Disease-Class=Asthma 19 conf:(1) 2853. Temporal Concept=years NUMERAL=17.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 19 ==> Disease-Class=Asthma 19 conf:(1) 2854. Temporal Concept=prior to NUMERAL=1.0 Spatial Concept=within Disease or S yndrome=asthma Individual Behavior=visit 19 ==> Disease-Class=Asthma 19 conf: (1) 2855. Pharmacologic Substance=bronchodilator UNIT=% Idea or Concept=predicted Q ualitative Concept=pre Diagnostic Procedure=fev1 19 ==> Disease-Class=Asthma 19 conf:(1) 2856. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Disease or Syndrome=asthma Finding=life 19 ==> Disease-Class= Asthma 19 conf:(1) 2857. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Disease or Syndrome=asthma Sign or Symptom=seizures 19 ==> Di sease-Class=Asthma 19 conf:(1) 2858. SYMBOL=- Therapeutic or Preventive Procedure=intubation Disease or Syndro me=asthma Finding=life Sign or Symptom=seizures 19 ==> Disease-Class=Asthma 19 conf:(1) 2859. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Disease or Syndrome=asthma Finding=life Sign or Symptom=seizures 19 == > Disease-Class=Asthma 19 conf:(1) 2860. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Disease or Syndrome=asthma Finding=life Sign or Symptom=seizu res 19 ==> Disease-Class=Asthma 19 conf:(1) 2861. Temporal Concept=episodes 18 ==> Disease-Class=Asthma 18 conf:(1) 2862. Intellectual Product=program 18 ==> Disease-Class=Asthma 18 conf:(1) 2863. Clinical Attribute=poor 18 ==> Disease-Class=Asthma 18 conf:(1) 2864. Pharmacologic Substance=beclomethasone 18 ==> Disease-Class=Asthma 18 conf:(1) 2865. Pharmacologic Substance=prednisolone 18 ==> Disease-Class=Asthma 18 co nf:(1) 2866. Idea or Concept=unscheduled 18 ==> Disease-Class=Asthma 18 conf:(1) 2867. Idea or Concept=restrictions 18 ==> Disease-Class=Asthma 18 conf:(1) 2868. Qualitative Concept=initial 18 ==> Disease-Class=Asthma 18 conf:(1) 2869. Qualitative Concept=poorly 18 ==> Disease-Class=Asthma 18 conf:(1) 2870. Population Group=cohort 18 ==> Disease-Class=Asthma 18 conf:(1) 2871. Therapeutic or Preventive Procedure=corticosteroid therapy 18 ==> Disease -Class=Asthma 18 conf:(1) 2872. Therapeutic or Preventive Procedure=surgically 18 ==> Disease-Class=Asthm

a 18 conf:(1) 2873. Functional Concept=starting 18 ==> Disease-Class=Asthma 18 conf:(1) 2874. Functional Concept=planning 18 ==> Disease-Class=Asthma 18 conf:(1) 2875. Functional Concept=involved 18 ==> Disease-Class=Asthma 18 conf:(1) 2876. Functional Concept=limit 18 ==> Disease-Class=Asthma 18 conf:(1) 2877. Spatial Concept=near 18 ==> Disease-Class=Asthma 18 conf:(1) 2878. Biomedical or Dental Material=aerosol 18 ==> Disease-Class=Asthma 18 c onf:(1) 2879. Disease or Syndrome=systemic disease 18 ==> Disease-Class=Asthma 18 co nf:(1) 2880. Disease or Syndrome=disease or disorder 18 ==> Disease-Class=Asthma 18 conf:(1) 2881. Disease or Syndrome=mf 18 ==> Disease-Class=Asthma 18 conf:(1) 2882. Natural Phenomenon or Process=flow 18 ==> Disease-Class=Asthma 18 conf :(1) 2883. Finding=moderate asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 2884. Finding=adverse reaction 18 ==> Disease-Class=Asthma 18 conf:(1) 2885. Classification=iv 18 ==> Disease-Class=Asthma 18 conf:(1) 2886. Conceptual Entity=listed 18 ==> Disease-Class=Asthma 18 conf:(1) 2887. Regulation or Law=informed consent form 18 ==> Disease-Class=Asthma 18 conf:(1) 2888. Diagnostic Procedure=exercise challenge 18 ==> Disease-Class=Asthma 18 conf:(1) 2889. Medical Device=telephone 18 ==> Disease-Class=Asthma 18 conf:(1) 2890. Physiologic Function=changed 18 ==> Disease-Class=Asthma 18 conf:(1) 2891. Patient or Disabled Group=patients NUMERAL=2.0 18 ==> Disease-Class=Asthm a 18 conf:(1) 2892. Patient or Disabled Group=patients Functional Concept=use of 18 ==> Disea se-Class=Asthma 18 conf:(1) 2893. Health Care Activity=diagnosis NUMERAL=3.0 18 ==> Disease-Class=Asthma 18 conf:(1) 2894. Health Care Activity=hospitalization Temporal Concept=months 18 ==> Disea se-Class=Asthma 18 conf:(1) 2895. Health Care Activity=enrollment SYMBOL=>= 18 ==> Disease-Class=Asthma 18 conf:(1) 2896. Health Care Activity=enrollment Spatial Concept=within 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 2897. Health Care Activity=documented NUMERAL=6.0 18 ==> Disease-Class=Asthma 1 8 conf:(1) 2898. Temporal Concept=years Qualitative Concept=last 18 ==> Disease-Class=Asth ma 18 conf:(1) 2899. Temporal Concept=days Qualitative Concept=last 18 ==> Disease-Class=Asthm a 18 conf:(1) 2900. Temporal Concept=history of Qualitative Concept=severe 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 2901. Temporal Concept=history of Professional or Occupational Group=physician 18 ==> Disease-Class=Asthma 18 conf:(1) 2902. Temporal Concept=history of Allergy=hypersensitivity 18 ==> Disease-Class =Asthma 18 conf:(1) 2903. Temporal Concept=after Functional Concept=increase 18 ==> Disease-Class=A sthma 18 conf:(1) 2904. Temporal Concept=prior to Intellectual Product=criteria 18 ==> Disease-Cl ass=Asthma 18 conf:(1) 2905. Temporal Concept=prior to Qualitative Concept=received 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 2906. Temporal Concept=prior to Functional Concept=including 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 2907. Temporal Concept=prior to Regulation or Law=informed consent 18 ==> Disea se-Class=Asthma 18 conf:(1) 2908. Temporal Concept=weeks Disease or Syndrome=respiratory tract infection 18

==> Disease-Class=Asthma 18 conf:(1) 2909. Temporal Concept=year SYMBOL=< 18 ==> Disease-Class=Asthma 18 conf:(1) 2910. Temporal Concept=year Quantitative Concept=one 18 ==> Disease-Class=Asthm a 18 conf:(1) 2911. Temporal Concept=history Disease or Syndrome=asthma 18 ==> Disease-Class= Asthma 18 conf:(1) 2912. Temporal Concept=day Quantitative Concept=puffs 18 ==> Disease-Class=Asth ma 18 conf:(1) 2913. Temporal Concept=before Body Space or Junction=oral 18 ==> Disease-Class= Asthma 18 conf:(1) 2914. Temporal Concept=chronic Disease or Syndrome=asthma 18 ==> Disease-Class= Asthma 18 conf:(1) 2915. Intellectual Product=methods SYMBOL=- 18 ==> Disease-Class=Asthma 18 c onf:(1) 2916. Intellectual Product=criteria NUMERAL=1.0 18 ==> Disease-Class=Asthma 18 conf:(1) 2917. Intellectual Product=pack years Behavior Problem=smoking 18 ==> Disease-C lass=Asthma 18 conf:(1) 2918. Intellectual Product=respiratory Research Activity=study 18 ==> Disease-C lass=Asthma 18 conf:(1) 2919. Intellectual Product=respiratory Qualitative Concept=other 18 ==> Disease -Class=Asthma 18 conf:(1) 2920. Pharmacologic Substance=medications Activity=taking 18 ==> Disease-Class= Asthma 18 conf:(1) 2921. Pharmacologic Substance=albuterol SYMBOL=- 18 ==> Disease-Class=Asthma 18 conf:(1) 2922. Pharmacologic Substance=drugs SYMBOL=- 18 ==> Disease-Class=Asthma 18 conf:(1) 2923. Pharmacologic Substance=medication SYMBOL=> 18 ==> Disease-Class=Asthma 1 8 conf:(1) 2924. Pharmacologic Substance=medication Therapeutic or Preventive Procedure=tr eatment 18 ==> Disease-Class=Asthma 18 conf:(1) 2925. Pharmacologic Substance=medication Therapeutic or Preventive Procedure=re scue 18 ==> Disease-Class=Asthma 18 conf:(1) 2926. Pharmacologic Substance=corticosteroid Therapeutic or Preventive Procedur e=treatment 18 ==> Disease-Class=Asthma 18 conf:(1) 2927. Pharmacologic Substance=corticosteroid Spatial Concept=within 18 ==> Dise ase-Class=Asthma 18 conf:(1) 2928. Pharmacologic Substance=corticosteroid Body Space or Junction=oral 18 ==> Disease-Class=Asthma 18 conf:(1) 2929. Pharmacologic Substance=steroids Disease or Syndrome=asthma 18 ==> Diseas e-Class=Asthma 18 conf:(1) 2930. Pharmacologic Substance=agonist Disease or Syndrome=asthma 18 ==> Disease -Class=Asthma 18 conf:(1) 2931. Pharmacologic Substance=pef SYMBOL=> 18 ==> Disease-Class=Asthma 18 co nf:(1) 2932. Pharmacologic Substance=pef Idea or Concept=predicted 18 ==> Disease-Clas s=Asthma 18 conf:(1) 2933. Pharmacologic Substance=corticosteroids NUMERAL=6.0 18 ==> Disease-Class= Asthma 18 conf:(1) 2934. Pharmacologic Substance=drug Quantitative Concept=dose 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 2935. Pharmacologic Substance=bronchodilator SYMBOL=< 18 ==> Disease-Class=Asth ma 18 conf:(1) 2936. NO=no SYMBOL=> 18 ==> Disease-Class=Asthma 18 conf:(1) 2937. NO=no Spatial Concept=within 18 ==> Disease-Class=Asthma 18 conf:(1) 2938. NO=not Qualitative Concept=from 18 ==> Disease-Class=Asthma 18 conf:(1 ) 2939. NO=not Functional Concept=including 18 ==> Disease-Class=Asthma 18 con f:(1)

2940. SYMBOL=- Qualitative Concept=longer 18 ==> Disease-Class=Asthma 18 con f:(1) 2941. SYMBOL=- Functional Concept=compliance 18 ==> Disease-Class=Asthma 18 conf:(1) 2942. SYMBOL=- Biologically Active Substance=leukotriene 18 ==> Disease-Class=A sthma 18 conf:(1) 2943. SYMBOL=- Manufactured Object=controller 18 ==> Disease-Class=Asthma 18 conf:(1) 2944. SYMBOL=> NUMERAL=20.0 18 ==> Disease-Class=Asthma 18 conf:(1) 2945. SYMBOL=> Organism Attribute=female 18 ==> Disease-Class=Asthma 18 conf :(1) 2946. SYMBOL=< Research Activity=study 18 ==> Disease-Class=Asthma 18 conf:( 1) 2947. SYMBOL=< Finding=smoking history 18 ==> Disease-Class=Asthma 18 conf:( 1) 2948. SYMBOL=>= Qualitative Concept=last 18 ==> Disease-Class=Asthma 18 conf :(1) 2949. SYMBOL=>= Qualitative Concept=has 18 ==> Disease-Class=Asthma 18 conf: (1) 2950. SYMBOL=>= Therapeutic or Preventive Procedure=therapy 18 ==> Disease-Clas s=Asthma 18 conf:(1) 2951. SYMBOL=<= Quantitative Concept=ml 18 ==> Disease-Class=Asthma 18 conf: (1) 2952. SYMBOL=<= Individual Behavior=visit 18 ==> Disease-Class=Asthma 18 con f:(1) 2953. NUMERAL=30.0 Disease or Syndrome=asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 2954. NUMERAL=2.0 Functional Concept=use 18 ==> Disease-Class=Asthma 18 conf :(1) 2955. NUMERAL=2.0 Individual Behavior=visits 18 ==> Disease-Class=Asthma 18 conf:(1) 2956. NUMERAL=4.0 Quantitative Concept=puffs 18 ==> Disease-Class=Asthma 18 conf:(1) 2957. NUMERAL=4.0 Sign or Symptom=run 18 ==> Disease-Class=Asthma 18 conf:(1 ) 2958. NUMERAL=4.0 Human=subjects 18 ==> Disease-Class=Asthma 18 conf:(1) 2959. NUMERAL=1.0 Sign or Symptom=symptoms 18 ==> Disease-Class=Asthma 18 co nf:(1) 2960. NUMERAL=14.0 Idea or Concept=eligible 18 ==> Disease-Class=Asthma 18 c onf:(1) 2961. NUMERAL=500.0 Quantitative Concept=mcg 18 ==> Disease-Class=Asthma 18 conf:(1) 2962. Quantitative Concept=one Laboratory Procedure=screening 18 ==> Disease-Cl ass=Asthma 18 conf:(1) 2963. Quantitative Concept=present Research Activity=study 18 ==> Disease-Class =Asthma 18 conf:(1) 2964. Quantitative Concept=short Laboratory Procedure=screening 18 ==> DiseaseClass=Asthma 18 conf:(1) 2965. Quantitative Concept=dose Human=subject 18 ==> Disease-Class=Asthma 18 conf:(1) 2966. UNIT=% Research Activity=randomization 18 ==> Disease-Class=Asthma 18 conf:(1) 2967. UNIT=% Sign or Symptom=symptoms 18 ==> Disease-Class=Asthma 18 conf:(1 ) 2968. UNIT=% Diagnostic Procedure=methacholine challenge 18 ==> Disease-Class=A sthma 18 conf:(1) 2969. Organism Attribute=female Organism Function=pregnant 18 ==> Disease-Class =Asthma 18 conf:(1) 2970. Organism Attribute=females Functional Concept=using 18 ==> Disease-Class= Asthma 18 conf:(1)

2971. Organism Attribute=females Age Group=age 18 ==> Disease-Class=Asthma 18 conf:(1) 2972. Organism Attribute=females Contraception=contraception 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 2973. Idea or Concept=acting Diagnostic Procedure=fev1 18 ==> Disease-Class=Ast hma 18 conf:(1) 2974. Idea or Concept=expected Research Activity=study 18 ==> Disease-Class=Ast hma 18 conf:(1) 2975. Research Activity=study Qualitative Concept=beta 18 ==> Disease-Class=Ast hma 18 conf:(1) 2976. Research Activity=study Therapeutic or Preventive Procedure=administratio n 18 ==> Disease-Class=Asthma 18 conf:(1) 2977. Research Activity=study Functional Concept=outcome 18 ==> Disease-Class=A sthma 18 conf:(1) 2978. Research Activity=study Spatial Concept=up 18 ==> Disease-Class=Asthma 18 conf:(1) 2979. Research Activity=study Spatial Concept=site 18 ==> Disease-Class=Asthma 18 conf:(1) 2980. Research Activity=study Sign or Symptom=conditions 18 ==> Disease-Class=A sthma 18 conf:(1) 2981. Research Activity=study Sign or Symptom=signed 18 ==> Disease-Class=Asthm a 18 conf:(1) 2982. Research Activity=study Social Behavior=allowed 18 ==> Disease-Class=Asth ma 18 conf:(1) 2983. Research Activity=randomization Laboratory Procedure=screening 18 ==> Dis ease-Class=Asthma 18 conf:(1) 2984. Research Activity=trial Spatial Concept=within 18 ==> Disease-Class=Asthm a 18 conf:(1) 2985. Qualitative Concept=negative Laboratory Procedure=screening 18 ==> Diseas e-Class=Asthma 18 conf:(1) 2986. Qualitative Concept=beta Individual Behavior=visit 18 ==> Disease-Class=A sthma 18 conf:(1) 2987. Qualitative Concept=regular Disease or Syndrome=asthma 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 2988. Qualitative Concept=from Diagnostic Procedure=fev1 18 ==> Disease-Class=A sthma 18 conf:(1) 2989. Qualitative Concept=protocol Human=subject 18 ==> Disease-Class=Asthma 18 conf:(1) 2990. Qualitative Concept=stable Laboratory Procedure=screening 18 ==> DiseaseClass=Asthma 18 conf:(1) 2991. Qualitative Concept=potential Population Group=women 18 ==> Disease-Class =Asthma 18 conf:(1) 2992. Therapeutic or Preventive Procedure=anti Sign or Symptom=inflammatory 18 ==> Disease-Class=Asthma 18 conf:(1) 2993. Therapeutic or Preventive Procedure=administration Individual Behavior=vi sit 18 ==> Disease-Class=Asthma 18 conf:(1) 2994. Therapeutic or Preventive Procedure=procedures Human=subject 18 ==> Disea se-Class=Asthma 18 conf:(1) 2995. Functional Concept=use of Human=subject 18 ==> Disease-Class=Asthma 18 conf:(1) 2996. Functional Concept=requiring Activity=inhaled 18 ==> Disease-Class=Asthma 18 conf:(1) 2997. Functional Concept=requiring Individual Behavior=visit 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 2998. Functional Concept=participate Human=subject 18 ==> Disease-Class=Asthma 18 conf:(1) 2999. Functional Concept=including Spatial Concept=up to 18 ==> Disease-Class=A sthma 18 conf:(1) 3000. Functional Concept=using Pathologic Function=sterile 18 ==> Disease-Class =Asthma 18 conf:(1)

3001. Functional Concept=using Human=subjects 18 ==> Disease-Class=Asthma 18 conf:(1) 3002. Functional Concept=using Willing=agree 18 ==> Disease-Class=Asthma 18 conf:(1) 3003. Spatial Concept=between Laboratory Procedure=screening 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 3004. Spatial Concept=between Human=subject 18 ==> Disease-Class=Asthma 18 c onf:(1) 3005. Spatial Concept=within Sign or Symptom=symptoms 18 ==> Disease-Class=Asth ma 18 conf:(1) 3006. Organism Function=inhalation Individual Behavior=visit 18 ==> Disease-Cla ss=Asthma 18 conf:(1) 3007. Disease or Syndrome=asthma Professional or Occupational Group=medical 18 ==> Disease-Class=Asthma 18 conf:(1) 3008. Disease or Syndrome=asthma Health Care Related Organization=nhlbi 18 ==> Disease-Class=Asthma 18 conf:(1) 3009. Disease or Syndrome=disease Human=subject 18 ==> Disease-Class=Asthma 18 conf:(1) 3010. Laboratory Procedure=screening Age Group=age 18 ==> Disease-Class=Asthma 18 conf:(1) 3011. Laboratory Procedure=screening Sign or Symptom=symptoms 18 ==> Disease-Cl ass=Asthma 18 conf:(1) 3012. Laboratory Procedure=screening Sign or Symptom=run 18 ==> Disease-Class=A sthma 18 conf:(1) 3013. Finding=smoking history Behavior Problem=smoked 18 ==> Disease-Class=Asth ma 18 conf:(1) 3014. Body Location or Region=hepatic Body System=endocrine 18 ==> Disease-Clas s=Asthma 18 conf:(1) 3015. Activity=inhaled Human=subject 18 ==> Disease-Class=Asthma 18 conf:(1) 3016. Body Space or Junction=oral Human=subjects 18 ==> Disease-Class=Asthma 18 conf:(1) 3017. Human=subjects Contraception=contraception 18 ==> Disease-Class=Asthma 18 conf:(1) 3018. Willing=agree Contraception=condom 18 ==> Disease-Class=Asthma 18 conf :(1) 3019. Patient or Disabled Group=patients Temporal Concept=prior to Spatial Conc ept=within 18 ==> Disease-Class=Asthma 18 conf:(1) 3020. Patient or Disabled Group=patients SYMBOL=- Organism Attribute=female 18 ==> Disease-Class=Asthma 18 conf:(1) 3021. Patient or Disabled Group=patient SYMBOL=- Disease or Syndrome=asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 3022. Patient or Disabled Group=patient Idea or Concept=opinion Professional or Occupational Group=investigator 18 ==> Disease-Class=Asthma 18 conf:(1) 3023. Patient or Disabled Group=patient Qualitative Concept=has Spatial Concept =within 18 ==> Disease-Class=Asthma 18 conf:(1) 3024. Patient or Disabled Group=patient Qualitative Concept=has Disease or Synd rome=asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 3025. Patient or Disabled Group=patient Spatial Concept=within Individual Behav ior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3026. Health Care Activity=diagnosis SYMBOL=>= NUMERAL=6.0 18 ==> Disease-Class =Asthma 18 conf:(1) 3027. Health Care Activity=hospitalization Disease or Syndrome=asthma Laborator y Procedure=screening 18 ==> Disease-Class=Asthma 18 conf:(1) 3028. Health Care Activity=documented Laboratory Procedure=screening Individual Behavior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3029. Temporal Concept=years SYMBOL=- Disease or Syndrome=asthma 18 ==> Disease -Class=Asthma 18 conf:(1) 3030. Temporal Concept=years NUMERAL=14.0 Idea or Concept=eligible 18 ==> Disea se-Class=Asthma 18 conf:(1) 3031. Temporal Concept=years NUMERAL=14.0 Research Activity=study 18 ==> Diseas

e-Class=Asthma 18 conf:(1) 3032. Temporal Concept=years Functional Concept=inclusive Age Group=aged 18 ==> Disease-Class=Asthma 18 conf:(1) 3033. Temporal Concept=days Research Activity=study Spatial Concept=within 18 = => Disease-Class=Asthma 18 conf:(1) 3034. Temporal Concept=prior to Pharmacologic Substance=medication Laboratory P rocedure=screening 18 ==> Disease-Class=Asthma 18 conf:(1) 3035. Temporal Concept=prior to NUMERAL=2.0 Laboratory Procedure=screening 18 = => Disease-Class=Asthma 18 conf:(1) 3036. Temporal Concept=prior to Laboratory Procedure=screening Body Space or Ju nction=oral 18 ==> Disease-Class=Asthma 18 conf:(1) 3037. Temporal Concept=weeks Pharmacologic Substance=corticosteroids Body Space or Junction=oral 18 ==> Disease-Class=Asthma 18 conf:(1) 3038. Temporal Concept=weeks Qualitative Concept=last Spatial Concept=within 18 ==> Disease-Class=Asthma 18 conf:(1) 3039. Temporal Concept=year NUMERAL=10.0 Finding=smoking history 18 ==> Disease -Class=Asthma 18 conf:(1) 3040. Temporal Concept=day SYMBOL=- Research Activity=study 18 ==> Disease-Clas s=Asthma 18 conf:(1) 3041. Intellectual Product=guidelines Research Activity=gina Social Behavior=ac cording 18 ==> Disease-Class=Asthma 18 conf:(1) 3042. Pharmacologic Substance=agonists SYMBOL=- Disease or Syndrome=asthma 18 = => Disease-Class=Asthma 18 conf:(1) 3043. Pharmacologic Substance=agonists Idea or Concept=acting Activity=inhaled 18 ==> Disease-Class=Asthma 18 conf:(1) 3044. Pharmacologic Substance=medication Research Activity=study Human=subject 18 ==> Disease-Class=Asthma 18 conf:(1) 3045. Pharmacologic Substance=steroids Spatial Concept=within Body Space or Jun ction=oral 18 ==> Disease-Class=Asthma 18 conf:(1) 3046. Pharmacologic Substance=corticosteroids SYMBOL=- Activity=inhaled 18 ==> Disease-Class=Asthma 18 conf:(1) 3047. Pharmacologic Substance=corticosteroids NUMERAL=3.0 Body Space or Junctio n=oral 18 ==> Disease-Class=Asthma 18 conf:(1) 3048. Pharmacologic Substance=corticosteroids Research Activity=study Body Spac e or Junction=oral 18 ==> Disease-Class=Asthma 18 conf:(1) 3049. Pharmacologic Substance=corticosteroids Therapeutic or Preventive Procedu re=treatment Spatial Concept=within 18 ==> Disease-Class=Asthma 18 conf:(1) 3050. Pharmacologic Substance=corticosteroids Disease or Syndrome=asthma Activi ty=inhaled 18 ==> Disease-Class=Asthma 18 conf:(1) 3051. NO=not Research Activity=study Human=subjects 18 ==> Disease-Class=Asthma 18 conf:(1) 3052. SYMBOL=- NUMERAL=10.0 Therapeutic or Preventive Procedure=ex 18 ==> Disea se-Class=Asthma 18 conf:(1) 3053. SYMBOL=- NUMERAL=10.0 Behavior Problem=smoking 18 ==> Disease-Class=Asthm a 18 conf:(1) 3054. SYMBOL=- NUMERAL=2.0 Disease or Syndrome=asthma 18 ==> Disease-Class=Asth ma 18 conf:(1) 3055. SYMBOL=- Research Activity=study Qualitative Concept=from 18 ==> DiseaseClass=Asthma 18 conf:(1) 3056. SYMBOL=- Research Activity=study Functional Concept=including 18 ==> Dise ase-Class=Asthma 18 conf:(1) 3057. SYMBOL=- Qualitative Concept=associated with Pathologic Function=hypoxic 18 ==> Disease-Class=Asthma 18 conf:(1) 3058. SYMBOL=- Pathologic Function=hypoxic Sign or Symptom=seizures 18 ==> Dise ase-Class=Asthma 18 conf:(1) 3059. SYMBOL=- Laboratory Procedure=screening Human=subject 18 ==> Disease-Clas s=Asthma 18 conf:(1) 3060. SYMBOL=- Individual Behavior=visit Human=subjects 18 ==> Disease-Class=As thma 18 conf:(1) 3061. SYMBOL=> Spatial Concept=within Individual Behavior=visit 18 ==> Disease-

Class=Asthma 18 conf:(1) 3062. SYMBOL=>= Spatial Concept=within Diagnostic Procedure=fev1 18 ==> Disease -Class=Asthma 18 conf:(1) 3063. SYMBOL=>= Diagnostic Procedure=fev1 Individual Behavior=visit 18 ==> Dise ase-Class=Asthma 18 conf:(1) 3064. NUMERAL=6.0 Spatial Concept=within Disease or Syndrome=asthma 18 ==> Dise ase-Class=Asthma 18 conf:(1) 3065. NUMERAL=4.0 Quantitative Concept=exacerbation Disease or Syndrome=asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 3066. NUMERAL=4.0 Research Activity=study Spatial Concept=within 18 ==> Disease -Class=Asthma 18 conf:(1) 3067. NUMERAL=4.0 Disease or Syndrome=asthma Laboratory Procedure=screening 18 ==> Disease-Class=Asthma 18 conf:(1) 3068. NUMERAL=14.0 Idea or Concept=eligible Research Activity=study 18 ==> Dise ase-Class=Asthma 18 conf:(1) 3069. Quantitative Concept=exacerbation Functional Concept=requiring Disease or Syndrome=asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 3070. Quantitative Concept=ml Laboratory or Test Result=pc20 UNIT=% 18 ==> Dise ase-Class=Asthma 18 conf:(1) 3071. Quantitative Concept=ml Diagnostic Procedure=fev1 Organic Chemical=methac holine 18 ==> Disease-Class=Asthma 18 conf:(1) 3072. Quantitative Concept=short Idea or Concept=acting Functional Concept=use of 18 ==> Disease-Class=Asthma 18 conf:(1) 3073. Quantitative Concept=dose Research Activity=study Spatial Concept=within 18 ==> Disease-Class=Asthma 18 conf:(1) 3074. UNIT=% Idea or Concept=predicted Human=subjects 18 ==> Disease-Class=Asth ma 18 conf:(1) 3075. UNIT=% Therapeutic or Preventive Procedure=administration Diagnostic Proc edure=fev1 18 ==> Disease-Class=Asthma 18 conf:(1) 3076. UNIT=% Functional Concept=increase Laboratory Procedure=screening 18 ==> Disease-Class=Asthma 18 conf:(1) 3077. UNIT=% Age Group=age Diagnostic Procedure=fev1 18 ==> Disease-Class=Asthm a 18 conf:(1) 3078. Organism Attribute=female Research Activity=study Human=subjects 18 ==> D isease-Class=Asthma 18 conf:(1) 3079. Idea or Concept=acting Functional Concept=use of Activity=inhaled 18 ==> Disease-Class=Asthma 18 conf:(1) 3080. Idea or Concept=acting Disease or Syndrome=ics Activity=inhaled 18 ==> Di sease-Class=Asthma 18 conf:(1) 3081. Research Activity=study Therapeutic or Preventive Procedure=procedures Ca pacity=able to 18 ==> Disease-Class=Asthma 18 conf:(1) 3082. Research Activity=study Functional Concept=participate Human=subjects 18 ==> Disease-Class=Asthma 18 conf:(1) 3083. Research Activity=study Functional Concept=start Disease or Syndrome=asth ma 18 ==> Disease-Class=Asthma 18 conf:(1) 3084. Research Activity=study Spatial Concept=within Finding=lives 18 ==> Disea se-Class=Asthma 18 conf:(1) 3085. Research Activity=study Laboratory Procedure=screening Individual Behavio r=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3086. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Pathologic Function=hypoxic 18 ==> Disease-Class=Asthma 18 conf:(1) 3087. Qualitative Concept=associated with Pathologic Function=hypoxic Finding=l ife 18 ==> Disease-Class=Asthma 18 conf:(1) 3088. Therapeutic or Preventive Procedure=intubation Pathologic Function=hypoxi c Sign or Symptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3089. Functional Concept=systemic Spatial Concept=within Laboratory Procedure=s creening 18 ==> Disease-Class=Asthma 18 conf:(1) 3090. Functional Concept=systemic Spatial Concept=within Body Space or Junction =oral 18 ==> Disease-Class=Asthma 18 conf:(1) 3091. Functional Concept=systemic Laboratory Procedure=screening Individual Beh

avior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3092. Pathologic Function=hypoxic Finding=life Sign or Symptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3093. Temporal Concept=years NUMERAL=14.0 Idea or Concept=eligible Research Act ivity=study 18 ==> Disease-Class=Asthma 18 conf:(1) 3094. Temporal Concept=prior to SYMBOL=- Spatial Concept=within Laboratory Proc edure=screening 18 ==> Disease-Class=Asthma 18 conf:(1) 3095. Temporal Concept=prior to NUMERAL=1.0 Laboratory Procedure=screening Indi vidual Behavior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3096. Temporal Concept=prior to NUMERAL=12.0 Spatial Concept=within Individual Behavior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3097. Temporal Concept=prior to Spatial Concept=within Disease or Syndrome=asth ma Laboratory Procedure=screening 18 ==> Disease-Class=Asthma 18 conf:(1) 3098. Temporal Concept=prior to Spatial Concept=within Body Space or Junction=o ral Individual Behavior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3099. Temporal Concept=weeks NUMERAL=4.0 Spatial Concept=within Disease or Synd rome=asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 3100. Temporal Concept=months NUMERAL=3.0 Spatial Concept=within Disease or Syn drome=asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 3101. NO=not NUMERAL=1.0 Research Activity=study Individual Behavior=visit 18 = => Disease-Class=Asthma 18 conf:(1) 3102. SYMBOL=- NUMERAL=5.0 Spatial Concept=within Finding=lives 18 ==> DiseaseClass=Asthma 18 conf:(1) 3103. SYMBOL=- NUMERAL=1.0 Laboratory Procedure=screening Individual Behavior=v isit 18 ==> Disease-Class=Asthma 18 conf:(1) 3104. SYMBOL=- Qualitative Concept=associated with Pathologic Function=hypoxic Disease or Syndrome=asthma 18 ==> Disease-Class=Asthma 18 conf:(1) 3105. SYMBOL=- Qualitative Concept=associated with Pathologic Function=hypoxic Finding=life 18 ==> Disease-Class=Asthma 18 conf:(1) 3106. SYMBOL=- Qualitative Concept=associated with Pathologic Function=hypoxic Sign or Symptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3107. SYMBOL=- Pathologic Function=hypoxic Disease or Syndrome=asthma Sign or S ymptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3108. SYMBOL=- Pathologic Function=hypoxic Finding=life Sign or Symptom=seizure s 18 ==> Disease-Class=Asthma 18 conf:(1) 3109. SYMBOL=>= UNIT=% Spatial Concept=within Diagnostic Procedure=fev1 18 ==> Disease-Class=Asthma 18 conf:(1) 3110. SYMBOL=>= UNIT=% Diagnostic Procedure=fev1 Individual Behavior=visit 18 = => Disease-Class=Asthma 18 conf:(1) 3111. NUMERAL=1.0 Research Activity=study Spatial Concept=within Individual Beh avior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3112. Quantitative Concept=exacerbation Spatial Concept=within Disease or Syndr ome=asthma Individual Behavior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3113. UNIT=% Spatial Concept=within Laboratory Procedure=screening Diagnostic P rocedure=fev1 18 ==> Disease-Class=Asthma 18 conf:(1) 3114. Idea or Concept=opinion Research Activity=study Activity=put Individual B ehavior=participation 18 ==> Disease-Class=Asthma 18 conf:(1) 3115. Research Activity=study Professional or Occupational Group=investigator A ctivity=put Individual Behavior=participation 18 ==> Disease-Class=Asthma 18 conf:(1) 3116. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Pathologic Function=hypoxic Disease or Syndrome=asthma 18 ==> DiseaseClass=Asthma 18 conf:(1) 3117. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Pathologic Function=hypoxic Sign or Symptom=seizures 18 ==> Disease-Cl ass=Asthma 18 conf:(1) 3118. Qualitative Concept=associated with Pathologic Function=hypoxic Disease o r Syndrome=asthma Finding=life 18 ==> Disease-Class=Asthma 18 conf:(1) 3119. Qualitative Concept=associated with Pathologic Function=hypoxic Finding=l ife Sign or Symptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1)

3120. Therapeutic or Preventive Procedure=intubation Pathologic Function=hypoxi c Disease or Syndrome=asthma Sign or Symptom=seizures 18 ==> Disease-Class=Asthm a 18 conf:(1) 3121. Pathologic Function=hypoxic Disease or Syndrome=asthma Finding=life Sign or Symptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3122. Temporal Concept=prior to NUMERAL=12.0 Spatial Concept=within Laboratory Procedure=screening Individual Behavior=visit 18 ==> Disease-Class=Asthma 18 conf:(1) 3123. SYMBOL=- Qualitative Concept=associated with Pathologic Function=hypoxic Disease or Syndrome=asthma Finding=life 18 ==> Disease-Class=Asthma 18 conf:( 1) 3124. SYMBOL=- Qualitative Concept=associated with Pathologic Function=hypoxic Disease or Syndrome=asthma Sign or Symptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3125. SYMBOL=- Qualitative Concept=associated with Pathologic Function=hypoxic Finding=life Sign or Symptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3126. SYMBOL=- Pathologic Function=hypoxic Disease or Syndrome=asthma Finding=l ife Sign or Symptom=seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3127. Idea or Concept=opinion Research Activity=study Professional or Occupatio nal Group=investigator Activity=put Individual Behavior=participation 18 ==> Dis ease-Class=Asthma 18 conf:(1) 3128. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Pathologic Function=hypoxic Disease or Syndrome=asthma Sign or Symptom =seizures 18 ==> Disease-Class=Asthma 18 conf:(1) 3129. Qualitative Concept=associated with Pathologic Function=hypoxic Disease o r Syndrome=asthma Finding=life Sign or Symptom=seizures 18 ==> Disease-Class=Ast hma 18 conf:(1) 3130. SYMBOL=- Qualitative Concept=associated with Pathologic Function=hypoxic Disease or Syndrome=asthma Finding=life Sign or Symptom=seizures 18 ==> DiseaseClass=Asthma 18 conf:(1) 3131. Health Care Activity=none 17 ==> Disease-Class=Asthma 17 conf:(1) 3132. Temporal Concept=intermittent 17 ==> Disease-Class=Asthma 17 conf:(1) 3133. Temporal Concept=per week 17 ==> Disease-Class=Asthma 17 conf:(1) 3134. Temporal Concept=minutes 17 ==> Disease-Class=Asthma 17 conf:(1) 3135. Pharmacologic Substance=theophylline 17 ==> Disease-Class=Asthma 17 co nf:(1) 3136. NUMERAL=28.0 17 ==> Disease-Class=Asthma 17 conf:(1) 3137. Quantitative Concept=average 17 ==> Disease-Class=Asthma 17 conf:(1) 3138. Quantitative Concept=half 17 ==> Disease-Class=Asthma 17 conf:(1) 3139. Idea or Concept=definition 17 ==> Disease-Class=Asthma 17 conf:(1) 3140. Idea or Concept=restricted 17 ==> Disease-Class=Asthma 17 conf:(1) 3141. Qualitative Concept=variability 17 ==> Disease-Class=Asthma 17 conf:(1 ) 3142. Qualitative Concept=possible 17 ==> Disease-Class=Asthma 17 conf:(1) 3143. Qualitative Concept=hormonal 17 ==> Disease-Class=Asthma 17 conf:(1) 3144. Functional Concept=given 17 ==> Disease-Class=Asthma 17 conf:(1) 3145. Functional Concept=neurological 17 ==> Disease-Class=Asthma 17 conf:(1 ) 3146. Functional Concept=step 17 ==> Disease-Class=Asthma 17 conf:(1) 3147. Organism Function=nursing 17 ==> Disease-Class=Asthma 17 conf:(1) 3148. Biomedical or Dental Material=excipients 17 ==> Disease-Class=Asthma 17 conf:(1) 3149. Finding=life threatening 17 ==> Disease-Class=Asthma 17 conf:(1) 3150. Organ or Tissue Function=fvc 17 ==> Disease-Class=Asthma 17 conf:(1) 3151. Classification=ii 17 ==> Disease-Class=Asthma 17 conf:(1) 3152. Age Group=adult 17 ==> Disease-Class=Asthma 17 conf:(1) 3153. Sign or Symptom=shortness of breath 17 ==> Disease-Class=Asthma 17 con f:(1) 3154. Activity=recruited 17 ==> Disease-Class=Asthma 17 conf:(1) 3155. Mammal=cat 17 ==> Disease-Class=Asthma 17 conf:(1)

3156. Health Care Related Organization=emergency department 17 ==> Disease-Clas s=Asthma 17 conf:(1) 3157. Substance=medium 17 ==> Disease-Class=Asthma 17 conf:(1) 3158. Capacity=able 17 ==> Disease-Class=Asthma 17 conf:(1) 3159. Patient or Disabled Group=patients NUMERAL=12.0 17 ==> Disease-Class=Asth ma 17 conf:(1) 3160. Patient or Disabled Group=patients Functional Concept=requiring 17 ==> Di sease-Class=Asthma 17 conf:(1) 3161. Patient or Disabled Group=patients Age Group=age 17 ==> Disease-Class=Ast hma 17 conf:(1) 3162. Patient or Disabled Group=patient Finding=written 17 ==> Disease-Class=As thma 17 conf:(1) 3163. Patient or Disabled Group=patient Human-caused Phenomenon or Process=safe ty 17 ==> Disease-Class=Asthma 17 conf:(1) 3164. Health Care Activity=documented Activity=inhaled 17 ==> Disease-Class=Ast hma 17 conf:(1) 3165. Health Care Activity=challenge Immunologic Factor=allergen 17 ==> Disease -Class=Asthma 17 conf:(1) 3166. Health Care Activity=prescription SYMBOL=- 17 ==> Disease-Class=Asthma 17 conf:(1) 3167. Temporal Concept=years NUMERAL=16.0 17 ==> Disease-Class=Asthma 17 con f:(1) 3168. Temporal Concept=years Hazardous or Poisonous Substance=cigarette smoking 17 ==> Disease-Class=Asthma 17 conf:(1) 3169. Temporal Concept=history of Functional Concept=including 17 ==> Disease-C lass=Asthma 17 conf:(1) 3170. Temporal Concept=prior to Functional Concept=use 17 ==> Disease-Class=Ast hma 17 conf:(1) 3171. Temporal Concept=prior to Professional or Occupational Group=investigator 17 ==> Disease-Class=Asthma 17 conf:(1) 3172. Temporal Concept=weeks Pharmacologic Substance=steroids 17 ==> Disease-Cl ass=Asthma 17 conf:(1) 3173. Temporal Concept=months Functional Concept=requiring 17 ==> Disease-Class =Asthma 17 conf:(1) 3174. Temporal Concept=months Functional Concept=systemic 17 ==> Disease-Class= Asthma 17 conf:(1) 3175. Temporal Concept=year Functional Concept=non 17 ==> Disease-Class=Asthma 17 conf:(1) 3176. Temporal Concept=throughout Research Activity=study 17 ==> Disease-Class= Asthma 17 conf:(1) 3177. Temporal Concept=before NUMERAL=4.0 17 ==> Disease-Class=Asthma 17 con f:(1) 3178. Temporal Concept=hours Idea or Concept=acting 17 ==> Disease-Class=Asthma 17 conf:(1) 3179. Temporal Concept=concomitant Activity=inhaled 17 ==> Disease-Class=Asthma 17 conf:(1) 3180. Intellectual Product=criteria SYMBOL=>= 17 ==> Disease-Class=Asthma 17 conf:(1) 3181. Intellectual Product=criteria Sign or Symptom=symptoms 17 ==> Disease-Cla ss=Asthma 17 conf:(1) 3182. Intellectual Product=pack years Manufactured Object=cigarettes 17 ==> Dis ease-Class=Asthma 17 conf:(1) 3183. Intellectual Product=pack years Behavior Problem=smoker 17 ==> Disease-Cl ass=Asthma 17 conf:(1) 3184. Pharmacologic Substance=medication NUMERAL=4.0 17 ==> Disease-Class=Asthm a 17 conf:(1) 3185. Pharmacologic Substance=corticosteroids NUMERAL=4.0 17 ==> Disease-Class= Asthma 17 conf:(1) 3186. Pharmacologic Substance=drug Human=subject 17 ==> Disease-Class=Asthma 17 conf:(1)

3187. Pharmacologic Substance=salbutamol Disease or Syndrome=asthma 17 ==> Dise ase-Class=Asthma 17 conf:(1) 3188. Pharmacologic Substance=salbutamol Human=subjects 17 ==> Disease-Class=As thma 17 conf:(1) 3189. NO=no SYMBOL=>= 17 ==> Disease-Class=Asthma 17 conf:(1) 3190. NO=no UNIT=% 17 ==> Disease-Class=Asthma 17 conf:(1) 3191. NO=no Idea or Concept=acting 17 ==> Disease-Class=Asthma 17 conf:(1) 3192. NO=no Human=subject 17 ==> Disease-Class=Asthma 17 conf:(1) 3193. NO=exclusion criteria Research Activity=study 17 ==> Disease-Class=Asthma 17 conf:(1) 3194. NO=exclusion criteria Activity=inhaled 17 ==> Disease-Class=Asthma 17 conf:(1) 3195. SYMBOL=- NUMERAL=18.0 17 ==> Disease-Class=Asthma 17 conf:(1) 3196. SYMBOL=- Quantitative Concept=or more 17 ==> Disease-Class=Asthma 17 c onf:(1) 3197. SYMBOL=- Quantitative Concept=mcg 17 ==> Disease-Class=Asthma 17 conf: (1) 3198. SYMBOL=- Virus=hiv 17 ==> Disease-Class=Asthma 17 conf:(1) 3199. SYMBOL=- Age Group=old 17 ==> Disease-Class=Asthma 17 conf:(1) 3200. SYMBOL=- Activity=taking 17 ==> Disease-Class=Asthma 17 conf:(1) 3201. SYMBOL=> Functional Concept=systemic 17 ==> Disease-Class=Asthma 17 co nf:(1) 3202. SYMBOL=>= NUMERAL=18.0 17 ==> Disease-Class=Asthma 17 conf:(1) 3203. SYMBOL=>= NUMERAL=80.0 17 ==> Disease-Class=Asthma 17 conf:(1) 3204. SYMBOL=>= Qualitative Concept=beta 17 ==> Disease-Class=Asthma 17 conf :(1) 3205. SYMBOL=>= Functional Concept=increase 17 ==> Disease-Class=Asthma 17 c onf:(1) 3206. SYMBOL=<= Laboratory Procedure=screening 17 ==> Disease-Class=Asthma 17 conf:(1) 3207. NUMERAL=10.0 Research Activity=study 17 ==> Disease-Class=Asthma 17 co nf:(1) 3208. NUMERAL=10.0 Qualitative Concept=total 17 ==> Disease-Class=Asthma 17 conf:(1) 3209. NUMERAL=10.0 Hazardous or Poisonous Substance=cigarette smoking 17 ==> Di sease-Class=Asthma 17 conf:(1) 3210. NUMERAL=6.0 Idea or Concept=eligible 17 ==> Disease-Class=Asthma 17 co nf:(1) 3211. NUMERAL=6.0 Functional Concept=use 17 ==> Disease-Class=Asthma 17 conf :(1) 3212. NUMERAL=2.0 Disease or Syndrome=lower respiratory tract infection 17 ==> Disease-Class=Asthma 17 conf:(1) 3213. NUMERAL=2.0 Diagnostic Procedure=fev1 17 ==> Disease-Class=Asthma 17 c onf:(1) 3214. NUMERAL=2.0 Body Space or Junction=oral 17 ==> Disease-Class=Asthma 17 conf:(1) 3215. NUMERAL=4.0 Human=subject 17 ==> Disease-Class=Asthma 17 conf:(1) 3216. NUMERAL=3.0 Quantitative Concept=exacerbation 17 ==> Disease-Class=Asthma 17 conf:(1) 3217. NUMERAL=3.0 Human=subjects 17 ==> Disease-Class=Asthma 17 conf:(1) 3218. NUMERAL=85.0 Idea or Concept=predicted 17 ==> Disease-Class=Asthma 17 conf:(1) 3219. NUMERAL=12.0 Activity=inhaled 17 ==> Disease-Class=Asthma 17 conf:(1) 3220. NUMERAL=15.0 Idea or Concept=eligible 17 ==> Disease-Class=Asthma 17 c onf:(1) 3221. NUMERAL=50.0 Diagnostic Procedure=fev1 17 ==> Disease-Class=Asthma 17 conf:(1) 3222. NUMERAL=80.0 Research Activity=study 17 ==> Disease-Class=Asthma 17 co nf:(1) 3223. NUMERAL=80.0 Age Group=ages 17 ==> Disease-Class=Asthma 17 conf:(1)

3224. NUMERAL=16.0 Research Activity=study 17 ==> Disease-Class=Asthma 17 co nf:(1) 3225. Quantitative Concept=baseline Qualitative Concept=from 17 ==> Disease-Cla ss=Asthma 17 conf:(1) 3226. Quantitative Concept=pack Functional Concept=non 17 ==> Disease-Class=Ast hma 17 conf:(1) 3227. Quantitative Concept=short UNIT=% 17 ==> Disease-Class=Asthma 17 conf: (1) 3228. Quantitative Concept=short Body Space or Junction=oral 17 ==> Disease-Cla ss=Asthma 17 conf:(1) 3229. Quantitative Concept=dose Body Space or Junction=oral 17 ==> Disease-Clas s=Asthma 17 conf:(1) 3230. Quantitative Concept=all Capacity=able to 17 ==> Disease-Class=Asthma 17 conf:(1) 3231. Quantitative Concept=normal value Diagnostic Procedure=fev1 17 ==> Diseas e-Class=Asthma 17 conf:(1) 3232. UNIT=% Qualitative Concept=from 17 ==> Disease-Class=Asthma 17 conf:(1 ) 3233. UNIT=time Individual Behavior=visit 17 ==> Disease-Class=Asthma 17 con f:(1) 3234. Organism Attribute=females Organism Function=lactating 17 ==> Disease-Cla ss=Asthma 17 conf:(1) 3235. Organism Attribute=females Laboratory Procedure=screening 17 ==> DiseaseClass=Asthma 17 conf:(1) 3236. Idea or Concept=acting Human=subjects 17 ==> Disease-Class=Asthma 17 c onf:(1) 3237. Idea or Concept=opinion Disease or Syndrome=disease 17 ==> Disease-Class= Asthma 17 conf:(1) 3238. Research Activity=study Functional Concept=affect 17 ==> Disease-Class=As thma 17 conf:(1) 3239. Research Activity=study Finding=sexually active 17 ==> Disease-Class=Asth ma 17 conf:(1) 3240. Research Activity=study Finding=compromise 17 ==> Disease-Class=Asthma 17 conf:(1) 3241. Research Activity=study Conceptual Entity=precautions 17 ==> Disease-Clas s=Asthma 17 conf:(1) 3242. Research Activity=study Diagnostic Procedure=fev1 17 ==> Disease-Class=As thma 17 conf:(1) 3243. Qualitative Concept=effective Functional Concept=using 17 ==> Disease-Cla ss=Asthma 17 conf:(1) 3244. Qualitative Concept=other Professional or Occupational Group=medical 17 = => Disease-Class=Asthma 17 conf:(1) 3245. Qualitative Concept=positive Diagnostic Procedure=methacholine challenge 17 ==> Disease-Class=Asthma 17 conf:(1) 3246. Qualitative Concept=consistent with Disease or Syndrome=asthma 17 ==> Dis ease-Class=Asthma 17 conf:(1) 3247. Qualitative Concept=beta Laboratory Procedure=screening 17 ==> Disease-Cl ass=Asthma 17 conf:(1) 3248. Qualitative Concept=significant Human-caused Phenomenon or Process=safety 17 ==> Disease-Class=Asthma 17 conf:(1) 3249. Qualitative Concept=received Spatial Concept=within 17 ==> Disease-Class= Asthma 17 conf:(1) 3250. Qualitative Concept=at risk Professional or Occupational Group=investigat or 17 ==> Disease-Class=Asthma 17 conf:(1) 3251. Therapeutic or Preventive Procedure=procedures Finding=written 17 ==> Dis ease-Class=Asthma 17 conf:(1) 3252. Functional Concept=use of Disease or Syndrome=diseases 17 ==> Disease-Cla ss=Asthma 17 conf:(1) 3253. Functional Concept=use of Sign or Symptom=symptoms 17 ==> Disease-Class=A sthma 17 conf:(1)

3254. Functional Concept=requiring Finding=life 17 ==> Disease-Class=Asthma 17 conf:(1) 3255. Functional Concept=using Contraception=condom 17 ==> Disease-Class=Asthma 17 conf:(1) 3256. Spatial Concept=between Individual Behavior=visit 17 ==> Disease-Class=As thma 17 conf:(1) 3257. Spatial Concept=up to Individual Behavior=visit 17 ==> Disease-Class=Asth ma 17 conf:(1) 3258. Spatial Concept=within Behavior Problem=smoked 17 ==> Disease-Class=Asthm a 17 conf:(1) 3259. Organism Function=inhalation Biomedical or Dental Material=aerosol 17 ==> Disease-Class=Asthma 17 conf:(1) 3260. Disease or Syndrome=asthma Diagnostic Procedure=clinical diagnosis 17 ==> Disease-Class=Asthma 17 conf:(1) 3261. Disease or Syndrome=lower respiratory tract infection Individual Behavior =visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3262. Laboratory Procedure=screening Body Substance=serum 17 ==> Disease-Class= Asthma 17 conf:(1) 3263. Finding=fall Diagnostic Procedure=fev1 17 ==> Disease-Class=Asthma 17 conf:(1) 3264. Finding=smoking history Behavior Problem=smokers 17 ==> Disease-Class=Ast hma 17 conf:(1) 3265. Finding=written Sign or Symptom=signed 17 ==> Disease-Class=Asthma 17 conf:(1) 3266. Finding=written Willing=willing 17 ==> Disease-Class=Asthma 17 conf:(1 ) 3267. Finding=sexually active Willing=agree 17 ==> Disease-Class=Asthma 17 c onf:(1) 3268. Professional or Occupational Group=investigator Sign or Symptom=condition 17 ==> Disease-Class=Asthma 17 conf:(1) 3269. Activity=interfere Individual Behavior=participation 17 ==> Disease-Class =Asthma 17 conf:(1) 3270. Human=subject Capacity=ability 17 ==> Disease-Class=Asthma 17 conf:(1) 3271. Willing=agree Contraception=contraception 17 ==> Disease-Class=Asthma 17 conf:(1) 3272. Patient or Disabled Group=patients Temporal Concept=prior to NUMERAL=1.0 17 ==> Disease-Class=Asthma 17 conf:(1) 3273. Patient or Disabled Group=patients SYMBOL=- Spatial Concept=within 17 ==> Disease-Class=Asthma 17 conf:(1) 3274. Patient or Disabled Group=patient SYMBOL=- Spatial Concept=within 17 ==> Disease-Class=Asthma 17 conf:(1) 3275. Patient or Disabled Group=patient Professional or Occupational Group=inve stigator Activity=put 17 ==> Disease-Class=Asthma 17 conf:(1) 3276. Health Care Activity=diagnosis Temporal Concept=months NUMERAL=6.0 17 ==> Disease-Class=Asthma 17 conf:(1) 3277. Health Care Activity=documented UNIT=% Individual Behavior=visit 17 ==> D isease-Class=Asthma 17 conf:(1) 3278. Temporal Concept=years SYMBOL=- Behavior Problem=smoking 17 ==> Disease-C lass=Asthma 17 conf:(1) 3279. Temporal Concept=years SYMBOL=>= Organism Attribute=female 17 ==> Disease -Class=Asthma 17 conf:(1) 3280. Temporal Concept=years NUMERAL=65.0 Age Group=age 17 ==> Disease-Class=As thma 17 conf:(1) 3281. Temporal Concept=years NUMERAL=15.0 Idea or Concept=eligible 17 ==> Disea se-Class=Asthma 17 conf:(1) 3282. Temporal Concept=years NUMERAL=14.0 Age Group=ages 17 ==> Disease-Class=A sthma 17 conf:(1) 3283. Temporal Concept=years NUMERAL=80.0 Age Group=ages 17 ==> Disease-Class=A sthma 17 conf:(1) 3284. Temporal Concept=prior to Pharmacologic Substance=corticosteroids Laborat

ory Procedure=screening 17 ==> Disease-Class=Asthma 17 conf:(1) 3285. Temporal Concept=prior to Pharmacologic Substance=corticosteroids Activit y=inhaled 17 ==> Disease-Class=Asthma 17 conf:(1) 3286. Temporal Concept=prior to Pharmacologic Substance=corticosteroids Individ ual Behavior=visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3287. Temporal Concept=prior to SYMBOL=> Spatial Concept=within 17 ==> DiseaseClass=Asthma 17 conf:(1) 3288. Temporal Concept=prior to SYMBOL=> Individual Behavior=visit 17 ==> Disea se-Class=Asthma 17 conf:(1) 3289. Temporal Concept=prior to SYMBOL=>= Idea or Concept=acting 17 ==> Disease -Class=Asthma 17 conf:(1) 3290. Temporal Concept=prior to NUMERAL=6.0 Research Activity=study 17 ==> Dise ase-Class=Asthma 17 conf:(1) 3291. Temporal Concept=prior to NUMERAL=4.0 Individual Behavior=visit 17 ==> Di sease-Class=Asthma 17 conf:(1) 3292. Temporal Concept=prior to NUMERAL=1.0 Therapeutic or Preventive Procedure =treatment 17 ==> Disease-Class=Asthma 17 conf:(1) 3293. Temporal Concept=prior to NUMERAL=1.0 Human=subject 17 ==> Disease-Class= Asthma 17 conf:(1) 3294. Temporal Concept=prior to Qualitative Concept=last Spatial Concept=within 17 ==> Disease-Class=Asthma 17 conf:(1) 3295. Temporal Concept=prior to Qualitative Concept=last Individual Behavior=vi sit 17 ==> Disease-Class=Asthma 17 conf:(1) 3296. Temporal Concept=prior to Individual Behavior=visit Human=subjects 17 ==> Disease-Class=Asthma 17 conf:(1) 3297. Temporal Concept=during Research Activity=study Laboratory Procedure=scre ening 17 ==> Disease-Class=Asthma 17 conf:(1) 3298. Temporal Concept=weeks SYMBOL=- NUMERAL=4.0 17 ==> Disease-Class=Asthma 1 7 conf:(1) 3299. Temporal Concept=weeks SYMBOL=- Activity=inhaled 17 ==> Disease-Class=Ast hma 17 conf:(1) 3300. Temporal Concept=weeks NUMERAL=6.0 Spatial Concept=within 17 ==> DiseaseClass=Asthma 17 conf:(1) 3301. Temporal Concept=weeks Laboratory Procedure=screening Individual Behavior =visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3302. Temporal Concept=months SYMBOL=- NUMERAL=3.0 17 ==> Disease-Class=Asthma 17 conf:(1) 3303. Temporal Concept=months NUMERAL=3.0 Functional Concept=use of 17 ==> Dise ase-Class=Asthma 17 conf:(1) 3304. Temporal Concept=months UNIT=% Spatial Concept=within 17 ==> Disease-Clas s=Asthma 17 conf:(1) 3305. Temporal Concept=months Laboratory Procedure=screening Individual Behavio r=visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3306. Temporal Concept=period SYMBOL=- Individual Behavior=visit 17 ==> Disease -Class=Asthma 17 conf:(1) 3307. Temporal Concept=day SYMBOL=- Quantitative Concept=puffs 17 ==> Disease-C lass=Asthma 17 conf:(1) 3308. Intellectual Product=criteria SYMBOL=- Disease or Syndrome=asthma 17 ==> Disease-Class=Asthma 17 conf:(1) 3309. Intellectual Product=criteria Research Activity=study Human=subject 17 == > Disease-Class=Asthma 17 conf:(1) 3310. Intellectual Product=pack years SYMBOL=> Finding=smoking history 17 ==> D isease-Class=Asthma 17 conf:(1) 3311. Intellectual Product=pack years NUMERAL=10.0 Therapeutic or Preventive Pr ocedure=ex 17 ==> Disease-Class=Asthma 17 conf:(1) 3312. Intellectual Product=method Research Activity=study Qualitative Concept=a cceptable 17 ==> Disease-Class=Asthma 17 conf:(1) 3313. Pharmacologic Substance=medication Research Activity=study Spatial Concep t=within 17 ==> Disease-Class=Asthma 17 conf:(1) 3314. Pharmacologic Substance=agonist Qualitative Concept=beta Activity=inhaled

17 ==> Disease-Class=Asthma 17 conf:(1) 3315. Pharmacologic Substance=corticosteroids SYMBOL=>= Activity=inhaled 17 ==> Disease-Class=Asthma 17 conf:(1) 3316. Pharmacologic Substance=corticosteroids Functional Concept=use of Activit y=inhaled 17 ==> Disease-Class=Asthma 17 conf:(1) 3317. Pharmacologic Substance=corticosteroids Disease or Syndrome=asthma Indivi dual Behavior=visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3318. Pharmacologic Substance=salbutamol UNIT=% Spatial Concept=within 17 ==> D isease-Class=Asthma 17 conf:(1) 3319. NO=not NUMERAL=1.0 Disease or Syndrome=asthma 17 ==> Disease-Class=Asthma 17 conf:(1) 3320. NO=not Spatial Concept=within Disease or Syndrome=asthma 17 ==> Disease-C lass=Asthma 17 conf:(1) 3321. NO=not Laboratory Procedure=screening Human=subject 17 ==> Disease-Class= Asthma 17 conf:(1) 3322. SYMBOL=- NUMERAL=5.0 Research Activity=study 17 ==> Disease-Class=Asthma 17 conf:(1) 3323. SYMBOL=- NUMERAL=6.0 Laboratory Procedure=screening 17 ==> Disease-Class= Asthma 17 conf:(1) 3324. SYMBOL=- NUMERAL=4.0 Sign or Symptom=run 17 ==> Disease-Class=Asthma 17 conf:(1) 3325. SYMBOL=- NUMERAL=4.0 Activity=inhaled 17 ==> Disease-Class=Asthma 17 c onf:(1) 3326. SYMBOL=- NUMERAL=12.0 Spatial Concept=within 17 ==> Disease-Class=Asthma 17 conf:(1) 3327. SYMBOL=- Idea or Concept=opinion Professional or Occupational Group=inves tigator 17 ==> Disease-Class=Asthma 17 conf:(1) 3328. SYMBOL=- Qualitative Concept=long Activity=inhaled 17 ==> Disease-Class=A sthma 17 conf:(1) 3329. SYMBOL=- Qualitative Concept=pre Diagnostic Procedure=fev1 17 ==> Disease -Class=Asthma 17 conf:(1) 3330. SYMBOL=- Functional Concept=requiring Finding=life 17 ==> Disease-Class=A sthma 17 conf:(1) 3331. SYMBOL=- Functional Concept=non Behavior Problem=smoker 17 ==> Disease-Cl ass=Asthma 17 conf:(1) 3332. SYMBOL=- Disease or Syndrome=asthma Age Group=age 17 ==> Disease-Class=As thma 17 conf:(1) 3333. SYMBOL=- Disease or Syndrome=asthma Human=subjects 17 ==> Disease-Class=A sthma 17 conf:(1) 3334. SYMBOL=- Laboratory Procedure=screening Sign or Symptom=run 17 ==> Diseas e-Class=Asthma 17 conf:(1) 3335. SYMBOL=- Laboratory Procedure=screening Activity=inhaled 17 ==> Disease-C lass=Asthma 17 conf:(1) 3336. SYMBOL=> NUMERAL=10.0 Finding=smoking history 17 ==> Disease-Class=Asthma 17 conf:(1) 3337. SYMBOL=> NUMERAL=70.0 Diagnostic Procedure=fev1 17 ==> Disease-Class=Asth ma 17 conf:(1) 3338. SYMBOL=> Quantitative Concept=baseline UNIT=% 17 ==> Disease-Class=Asthma 17 conf:(1) 3339. SYMBOL=> Quantitative Concept=baseline Diagnostic Procedure=fev1 17 ==> D isease-Class=Asthma 17 conf:(1) 3340. SYMBOL=> Disease or Syndrome=asthma Sign or Symptom=symptoms 17 ==> Disea se-Class=Asthma 17 conf:(1) 3341. SYMBOL=< Quantitative Concept=ml Organic Chemical=methacholine 17 ==> Dis ease-Class=Asthma 17 conf:(1) 3342. SYMBOL=>= NUMERAL=2.0 Laboratory Procedure=screening 17 ==> Disease-Class =Asthma 17 conf:(1) 3343. SYMBOL=>= NUMERAL=3.0 Disease or Syndrome=asthma 17 ==> Disease-Class=Ast hma 17 conf:(1) 3344. SYMBOL=>= NUMERAL=1.0 Laboratory Procedure=screening 17 ==> Disease-Class

=Asthma 17 conf:(1) 3345. SYMBOL=>= NUMERAL=80.0 UNIT=% 17 ==> Disease-Class=Asthma 17 conf:(1) 3346. SYMBOL=>= Research Activity=study Disease or Syndrome=asthma 17 ==> Disea se-Class=Asthma 17 conf:(1) 3347. SYMBOL=>= Therapeutic or Preventive Procedure=treatment Disease or Syndro me=asthma 17 ==> Disease-Class=Asthma 17 conf:(1) 3348. SYMBOL=>= Spatial Concept=within Individual Behavior=visit 17 ==> Disease -Class=Asthma 17 conf:(1) 3349. SYMBOL=>= Disease or Syndrome=asthma Diagnostic Procedure=diagnosed 17 == > Disease-Class=Asthma 17 conf:(1) 3350. NUMERAL=6.0 Idea or Concept=eligible Research Activity=study 17 ==> Disea se-Class=Asthma 17 conf:(1) 3351. NUMERAL=6.0 Research Activity=study Disease or Syndrome=asthma 17 ==> Dis ease-Class=Asthma 17 conf:(1) 3352. NUMERAL=6.0 Laboratory Procedure=screening Individual Behavior=visit 17 = => Disease-Class=Asthma 17 conf:(1) 3353. NUMERAL=20.0 UNIT=% Diagnostic Procedure=fev1 17 ==> Disease-Class=Asthma 17 conf:(1) 3354. NUMERAL=2.0 Research Activity=study Spatial Concept=within 17 ==> Disease -Class=Asthma 17 conf:(1) 3355. NUMERAL=2.0 Disease or Syndrome=asthma Sign or Symptom=symptoms 17 ==> Di sease-Class=Asthma 17 conf:(1) 3356. NUMERAL=4.0 Spatial Concept=within Body Space or Junction=oral 17 ==> Dis ease-Class=Asthma 17 conf:(1) 3357. NUMERAL=3.0 Disease or Syndrome=asthma Individual Behavior=visit 17 ==> D isease-Class=Asthma 17 conf:(1) 3358. NUMERAL=3.0 Laboratory Procedure=screening Individual Behavior=visit 17 = => Disease-Class=Asthma 17 conf:(1) 3359. NUMERAL=1.0 Research Activity=study Disease or Syndrome=asthma 17 ==> Dis ease-Class=Asthma 17 conf:(1) 3360. NUMERAL=1.0 Spatial Concept=within Human=subjects 17 ==> Disease-Class=As thma 17 conf:(1) 3361. NUMERAL=85.0 UNIT=% Idea or Concept=predicted 17 ==> Disease-Class=Asthma 17 conf:(1) 3362. NUMERAL=14.0 Idea or Concept=eligible Age Group=ages 17 ==> Disease-Class =Asthma 17 conf:(1) 3363. NUMERAL=14.0 Research Activity=study Age Group=ages 17 ==> Disease-Class= Asthma 17 conf:(1) 3364. Quantitative Concept=ml Laboratory or Test Result=pc20 Diagnostic Procedu re=fev1 17 ==> Disease-Class=Asthma 17 conf:(1) 3365. Quantitative Concept=ml UNIT=% Organic Chemical=methacholine 17 ==> Disea se-Class=Asthma 17 conf:(1) 3366. Quantitative Concept=normal value UNIT=% Diagnostic Procedure=fev1 17 ==> Disease-Class=Asthma 17 conf:(1) 3367. Quantitative Concept=could Research Activity=study Professional or Occupa tional Group=investigator 17 ==> Disease-Class=Asthma 17 conf:(1) 3368. UNIT=% Idea or Concept=acting Diagnostic Procedure=fev1 17 ==> Disease-Cl ass=Asthma 17 conf:(1) 3369. UNIT=% Functional Concept=increase Spatial Concept=within 17 ==> DiseaseClass=Asthma 17 conf:(1) 3370. UNIT=% Finding=fall Diagnostic Procedure=fev1 17 ==> Disease-Class=Asthma 17 conf:(1) 3371. Idea or Concept=opinion Professional or Occupational Group=investigator A ctivity=interfere 17 ==> Disease-Class=Asthma 17 conf:(1) 3372. Research Activity=study Functional Concept=participate Capacity=ability 1 7 ==> Disease-Class=Asthma 17 conf:(1) 3373. Research Activity=study Functional Concept=use Individual Behavior=visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3374. Research Activity=study Spatial Concept=within Laboratory Procedure=scree ning 17 ==> Disease-Class=Asthma 17 conf:(1)

3375. Qualitative Concept=beta Therapeutic or Preventive Procedure=treatment Ac tivity=inhaled 17 ==> Disease-Class=Asthma 17 conf:(1) 3376. Functional Concept=requiring Spatial Concept=within Disease or Syndrome=a sthma 17 ==> Disease-Class=Asthma 17 conf:(1) 3377. Laboratory Procedure=screening Professional or Occupational Group=investi gator Individual Behavior=visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3378. Patient or Disabled Group=patient Research Activity=study Professional or Occupational Group=investigator Activity=put 17 ==> Disease-Class=Asthma 17 conf:(1) 3379. Temporal Concept=years NUMERAL=14.0 Idea or Concept=eligible Age Group=ag es 17 ==> Disease-Class=Asthma 17 conf:(1) 3380. Temporal Concept=years NUMERAL=14.0 Research Activity=study Age Group=age s 17 ==> Disease-Class=Asthma 17 conf:(1) 3381. Temporal Concept=prior to Pharmacologic Substance=corticosteroids Spatial Concept=within Body Space or Junction=oral 17 ==> Disease-Class=Asthma 17 co nf:(1) 3382. Temporal Concept=prior to SYMBOL=>= Disease or Syndrome=asthma Laboratory Procedure=screening 17 ==> Disease-Class=Asthma 17 conf:(1) 3383. Temporal Concept=weeks Spatial Concept=within Laboratory Procedure=screen ing Individual Behavior=visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3384. Temporal Concept=months NUMERAL=3.0 Qualitative Concept=last Spatial Conc ept=within 17 ==> Disease-Class=Asthma 17 conf:(1) 3385. Temporal Concept=months NUMERAL=3.0 Spatial Concept=within Body Space or Junction=oral 17 ==> Disease-Class=Asthma 17 conf:(1) 3386. Pharmacologic Substance=corticosteroids Functional Concept=use of Spatial Concept=within Body Space or Junction=oral 17 ==> Disease-Class=Asthma 17 co nf:(1) 3387. Pharmacologic Substance=corticosteroids Spatial Concept=within Disease or Syndrome=asthma Body Space or Junction=oral 17 ==> Disease-Class=Asthma 17 c onf:(1) 3388. SYMBOL=- UNIT=% Idea or Concept=predicted Individual Behavior=visit 17 == > Disease-Class=Asthma 17 conf:(1) 3389. SYMBOL=- UNIT=% Functional Concept=increase Diagnostic Procedure=fev1 17 ==> Disease-Class=Asthma 17 conf:(1) 3390. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Pathologic Function=hypoxic 17 ==> Disease-Class=Asthma 17 conf:(1) 3391. SYMBOL=- Therapeutic or Preventive Procedure=intubation Pathologic Functi on=hypoxic Sign or Symptom=seizures 17 ==> Disease-Class=Asthma 17 conf:(1) 3392. SYMBOL=> NUMERAL=70.0 UNIT=% Diagnostic Procedure=fev1 17 ==> Disease-Cla ss=Asthma 17 conf:(1) 3393. NUMERAL=1.0 Quantitative Concept=exacerbation Spatial Concept=within Indi vidual Behavior=visit 17 ==> Disease-Class=Asthma 17 conf:(1) 3394. NUMERAL=14.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 17 ==> Disease-Class=Asthma 17 conf:(1) 3395. Idea or Concept=opinion Research Activity=study Professional or Occupatio nal Group=investigator Human=subject 17 ==> Disease-Class=Asthma 17 conf:(1) 3396. Research Activity=study Functional Concept=participate Professional or Oc cupational Group=investigator Capacity=ability 17 ==> Disease-Class=Asthma 17 conf:(1) 3397. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Pathologic Function=hypoxic Finding=life 17 ==> Disease-Class=Asthma 1 7 conf:(1) 3398. Therapeutic or Preventive Procedure=intubation Pathologic Function=hypoxi c Finding=life Sign or Symptom=seizures 17 ==> Disease-Class=Asthma 17 conf:( 1) 3399. Temporal Concept=years NUMERAL=14.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 17 ==> Disease-Class=Asthma 17 conf:(1) 3400. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Pathologic Function=hypoxic Disease or Syndrome=asthma 17 ==>

Disease-Class=Asthma 17 conf:(1) 3401. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Pathologic Function=hypoxic Finding=life 17 ==> Disease-Class =Asthma 17 conf:(1) 3402. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Pathologic Function=hypoxic Sign or Symptom=seizures 17 ==> D isease-Class=Asthma 17 conf:(1) 3403. SYMBOL=- Therapeutic or Preventive Procedure=intubation Pathologic Functi on=hypoxic Disease or Syndrome=asthma Sign or Symptom=seizures 17 ==> Disease-Cl ass=Asthma 17 conf:(1) 3404. SYMBOL=- Therapeutic or Preventive Procedure=intubation Pathologic Functi on=hypoxic Finding=life Sign or Symptom=seizures 17 ==> Disease-Class=Asthma 17 conf:(1) 3405. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Pathologic Function=hypoxic Disease or Syndrome=asthma Finding=life 17 ==> Disease-Class=Asthma 17 conf:(1) 3406. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Pathologic Function=hypoxic Finding=life Sign or Symptom=seizures 17 = => Disease-Class=Asthma 17 conf:(1) 3407. Therapeutic or Preventive Procedure=intubation Pathologic Function=hypoxi c Disease or Syndrome=asthma Finding=life Sign or Symptom=seizures 17 ==> Diseas e-Class=Asthma 17 conf:(1) 3408. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Pathologic Function=hypoxic Disease or Syndrome=asthma Findin g=life 17 ==> Disease-Class=Asthma 17 conf:(1) 3409. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Pathologic Function=hypoxic Disease or Syndrome=asthma Sign o r Symptom=seizures 17 ==> Disease-Class=Asthma 17 conf:(1) 3410. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Pathologic Function=hypoxic Finding=life Sign or Symptom=seiz ures 17 ==> Disease-Class=Asthma 17 conf:(1) 3411. SYMBOL=- Therapeutic or Preventive Procedure=intubation Pathologic Functi on=hypoxic Disease or Syndrome=asthma Finding=life Sign or Symptom=seizures 17 = => Disease-Class=Asthma 17 conf:(1) 3412. Qualitative Concept=associated with Therapeutic or Preventive Procedure=i ntubation Pathologic Function=hypoxic Disease or Syndrome=asthma Finding=life Si gn or Symptom=seizures 17 ==> Disease-Class=Asthma 17 conf:(1) 3413. SYMBOL=- Qualitative Concept=associated with Therapeutic or Preventive Pr ocedure=intubation Pathologic Function=hypoxic Disease or Syndrome=asthma Findin g=life Sign or Symptom=seizures 17 ==> Disease-Class=Asthma 17 conf:(1) 3414. Health Care Activity=report 16 ==> Disease-Class=Asthma 16 conf:(1) 3415. Health Care Activity=hospitalisation 16 ==> Disease-Class=Asthma 16 co nf:(1) 3416. Health Care Activity=scheduled 16 ==> Disease-Class=Asthma 16 conf:(1) 3417. Temporal Concept=seasonal 16 ==> Disease-Class=Asthma 16 conf:(1) 3418. Temporal Concept=yrs 16 ==> Disease-Class=Asthma 16 conf:(1) 3419. Intellectual Product=turbuhaler 16 ==> Disease-Class=Asthma 16 conf:(1 ) 3420. Pharmacologic Substance=bid 16 ==> Disease-Class=Asthma 16 conf:(1) 3421. Quantitative Concept=high dose 16 ==> Disease-Class=Asthma 16 conf:(1) 3422. Idea or Concept=ongoing 16 ==> Disease-Class=Asthma 16 conf:(1) 3423. Research Activity=on study 16 ==> Disease-Class=Asthma 16 conf:(1) 3424. Qualitative Concept=standard 16 ==> Disease-Class=Asthma 16 conf:(1) 3425. Qualitative Concept=applicable 16 ==> Disease-Class=Asthma 16 conf:(1) 3426. Qualitative Concept=likely 16 ==> Disease-Class=Asthma 16 conf:(1) 3427. Population Group=sexual partner 16 ==> Disease-Class=Asthma 16 conf:(1 ) 3428. Functional Concept=common 16 ==> Disease-Class=Asthma 16 conf:(1) 3429. Functional Concept=exclusion 16 ==> Disease-Class=Asthma 16 conf:(1) 3430. Functional Concept=planned 16 ==> Disease-Class=Asthma 16 conf:(1)

3431. Functional Concept=increased 16 ==> Disease-Class=Asthma 16 conf:(1) 3432. Spatial Concept=area 16 ==> Disease-Class=Asthma 16 conf:(1) 3433. Disease or Syndrome=disorder 16 ==> Disease-Class=Asthma 16 conf:(1) 3434. Disease or Syndrome=airway obstruction 16 ==> Disease-Class=Asthma 16 conf:(1) 3435. Conceptual Entity=assent 16 ==> Disease-Class=Asthma 16 conf:(1) 3436. Activity=preclude 16 ==> Disease-Class=Asthma 16 conf:(1) 3437. Medical Device=lead 16 ==> Disease-Class=Asthma 16 conf:(1) 3438. Medical Device=table 16 ==> Disease-Class=Asthma 16 conf:(1) 3439. Health Care Related Organization=clinic 16 ==> Disease-Class=Asthma 16 conf:(1) 3440. Family Group=relative 16 ==> Disease-Class=Asthma 16 conf:(1) 3441. Invertebrate=house dust mites 16 ==> Disease-Class=Asthma 16 conf:(1) 3442. Contraception=contraceptives 16 ==> Disease-Class=Asthma 16 conf:(1) 3443. Compliance=adherence 16 ==> Disease-Class=Asthma 16 conf:(1) 3444. Patient or Disabled Group=patients Health Care Activity=documented 16 ==> Disease-Class=Asthma 16 conf:(1) 3445. Patient or Disabled Group=patients Temporal Concept=persistent 16 ==> Dis ease-Class=Asthma 16 conf:(1) 3446. Patient or Disabled Group=patients NUMERAL=4.0 16 ==> Disease-Class=Asthm a 16 conf:(1) 3447. Patient or Disabled Group=patients Functional Concept=use 16 ==> DiseaseClass=Asthma 16 conf:(1) 3448. Patient or Disabled Group=patients Functional Concept=using 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3449. Patient or Disabled Group=patients Disease or Syndrome=ics 16 ==> Disease -Class=Asthma 16 conf:(1) 3450. Patient or Disabled Group=patients Sign or Symptom=symptoms 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3451. Patient or Disabled Group=patients Diagnostic Procedure=diagnosed 16 ==> Disease-Class=Asthma 16 conf:(1) 3452. Patient or Disabled Group=patient Temporal Concept=prior to 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3453. Patient or Disabled Group=patient SYMBOL=> 16 ==> Disease-Class=Asthma 16 conf:(1) 3454. Patient or Disabled Group=patient NUMERAL=3.0 16 ==> Disease-Class=Asthma 16 conf:(1) 3455. Patient or Disabled Group=patient Functional Concept=including 16 ==> Dis ease-Class=Asthma 16 conf:(1) 3456. Patient or Disabled Group=patient Diagnostic Procedure=fev1 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3457. Health Care Activity=diagnosis Intellectual Product=guidelines 16 ==> Dis ease-Class=Asthma 16 conf:(1) 3458. Health Care Activity=diagnosis Research Activity=study 16 ==> Disease-Cla ss=Asthma 16 conf:(1) 3459. Health Care Activity=diagnosis Individual Behavior=visit 16 ==> Disease-C lass=Asthma 16 conf:(1) 3460. Health Care Activity=prescribed Temporal Concept=prior to 16 ==> DiseaseClass=Asthma 16 conf:(1) 3461. Health Care Activity=prescribed NUMERAL=1.0 16 ==> Disease-Class=Asthma 1 6 conf:(1) 3462. Health Care Activity=prescribed Functional Concept=use of 16 ==> DiseaseClass=Asthma 16 conf:(1) 3463. Health Care Activity=prescribed Disease or Syndrome=asthma 16 ==> Disease -Class=Asthma 16 conf:(1) 3464. Health Care Activity=hospitalization Functional Concept=requiring 16 ==> Disease-Class=Asthma 16 conf:(1) 3465. Health Care Activity=hospitalization Health Care Related Organization=eme rgency room 16 ==> Disease-Class=Asthma 16 conf:(1) 3466. Health Care Activity=documented Human=subjects 16 ==> Disease-Class=Asthm

a 16 conf:(1) 3467. Temporal Concept=years Intellectual Product=pack years 16 ==> Disease-Cla ss=Asthma 16 conf:(1) 3468. Temporal Concept=years Laboratory Procedure=screening 16 ==> Disease-Clas s=Asthma 16 conf:(1) 3469. Temporal Concept=years Human=subject 16 ==> Disease-Class=Asthma 16 co nf:(1) 3470. Temporal Concept=days Pharmacologic Substance=investigational drug 16 ==> Disease-Class=Asthma 16 conf:(1) 3471. Temporal Concept=days NUMERAL=2.0 16 ==> Disease-Class=Asthma 16 conf: (1) 3472. Temporal Concept=history of Intellectual Product=pack years 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3473. Temporal Concept=history of Qualitative Concept=has 16 ==> Disease-Class= Asthma 16 conf:(1) 3474. Temporal Concept=prior to Pharmacologic Substance=corticosteroid 16 ==> D isease-Class=Asthma 16 conf:(1) 3475. Temporal Concept=prior to Quantitative Concept=short 16 ==> Disease-Class =Asthma 16 conf:(1) 3476. Temporal Concept=prior to Organism Attribute=female 16 ==> Disease-Class= Asthma 16 conf:(1) 3477. Temporal Concept=prior to Qualitative Concept=related 16 ==> Disease-Clas s=Asthma 16 conf:(1) 3478. Temporal Concept=prior to Therapeutic or Preventive Procedure=regimen 16 ==> Disease-Class=Asthma 16 conf:(1) 3479. Temporal Concept=prior to Finding=smoking history 16 ==> Disease-Class=As thma 16 conf:(1) 3480. Temporal Concept=prior to Sign or Symptom=run 16 ==> Disease-Class=Asthma 16 conf:(1) 3481. Temporal Concept=prior to Diagnostic Procedure=fev1 16 ==> Disease-Class= Asthma 16 conf:(1) 3482. Temporal Concept=during Individual Behavior=participation 16 ==> DiseaseClass=Asthma 16 conf:(1) 3483. Temporal Concept=weeks Functional Concept=systemic 16 ==> Disease-Class=A sthma 16 conf:(1) 3484. Temporal Concept=months Pharmacologic Substance=steroids 16 ==> Disease-C lass=Asthma 16 conf:(1) 3485. Temporal Concept=months Human=subject 16 ==> Disease-Class=Asthma 16 c onf:(1) 3486. Temporal Concept=year NO=not 16 ==> Disease-Class=Asthma 16 conf:(1) 3487. Temporal Concept=period NUMERAL=2.0 16 ==> Disease-Class=Asthma 16 con f:(1) 3488. Temporal Concept=before Pharmacologic Substance=corticosteroids 16 ==> Di sease-Class=Asthma 16 conf:(1) 3489. Temporal Concept=before NUMERAL=6.0 16 ==> Disease-Class=Asthma 16 con f:(1) 3490. Temporal Concept=chronic Sign or Symptom=condition 16 ==> Disease-Class=A sthma 16 conf:(1) 3491. Temporal Concept=preceding Laboratory Procedure=screening 16 ==> DiseaseClass=Asthma 16 conf:(1) 3492. Temporal Concept=past Quantitative Concept=present 16 ==> Disease-Class=A sthma 16 conf:(1) 3493. Temporal Concept=post Pharmacologic Substance=bronchodilator 16 ==> Disea se-Class=Asthma 16 conf:(1) 3494. Intellectual Product=criteria Laboratory Procedure=screening 16 ==> Disea se-Class=Asthma 16 conf:(1) 3495. Intellectual Product=criteria Social Behavior=according 16 ==> Disease-Cl ass=Asthma 16 conf:(1) 3496. Intellectual Product=guidelines SYMBOL=- 16 ==> Disease-Class=Asthma 16 conf:(1)

3497. Intellectual Product=method Contraception=condom 16 ==> Disease-Class=Ast hma 16 conf:(1) 3498. Clinical Attribute=inability Willing=unwillingness 16 ==> Disease-Class=A sthma 16 conf:(1) 3499. Clinical Attribute=bmi SYMBOL=- 16 ==> Disease-Class=Asthma 16 conf:(1 ) 3500. Pharmacologic Substance=albuterol SYMBOL=>= 16 ==> Disease-Class=Asthma 1 6 conf:(1) 3501. Pharmacologic Substance=medication Therapeutic or Preventive Procedure=pr ocedures 16 ==> Disease-Class=Asthma 16 conf:(1) 3502. Pharmacologic Substance=agonist NUMERAL=2.0 16 ==> Disease-Class=Asthma 1 6 conf:(1) 3503. Pharmacologic Substance=corticosteroids NO=not 16 ==> Disease-Class=Asthm a 16 conf:(1) 3504. Pharmacologic Substance=drug Individual Behavior=participation 16 ==> Dis ease-Class=Asthma 16 conf:(1) 3505. Pharmacologic Substance=salbutamol NUMERAL=1.0 16 ==> Disease-Class=Asthm a 16 conf:(1) 3506. Pharmacologic Substance=salbutamol Functional Concept=use 16 ==> DiseaseClass=Asthma 16 conf:(1) 3507. Pharmacologic Substance=bronchodilator Disease or Syndrome=asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3508. Pharmacologic Substance=bronchodilator Laboratory Procedure=screening 16 ==> Disease-Class=Asthma 16 conf:(1) 3509. Pharmacologic Substance=fluticasone Disease or Syndrome=ics 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3510. NO=no Human=subjects 16 ==> Disease-Class=Asthma 16 conf:(1) 3511. NO=not UNIT=time 16 ==> Disease-Class=Asthma 16 conf:(1) 3512. NO=not Qualitative Concept=potential 16 ==> Disease-Class=Asthma 16 co nf:(1) 3513. NO=not Functional Concept=use of 16 ==> Disease-Class=Asthma 16 conf:( 1) 3514. NO=not Sign or Symptom=conditions 16 ==> Disease-Class=Asthma 16 conf: (1) 3515. SYMBOL=- Therapeutic or Preventive Procedure=treated with 16 ==> DiseaseClass=Asthma 16 conf:(1) 3516. SYMBOL=- Functional Concept=active 16 ==> Disease-Class=Asthma 16 conf :(1) 3517. SYMBOL=- Body Substance=serum 16 ==> Disease-Class=Asthma 16 conf:(1) 3518. SYMBOL=- Sign or Symptom=inflammatory 16 ==> Disease-Class=Asthma 16 c onf:(1) 3519. SYMBOL=- Activity=receipt 16 ==> Disease-Class=Asthma 16 conf:(1) 3520. SYMBOL=- Social Behavior=allowed 16 ==> Disease-Class=Asthma 16 conf:( 1) 3521. SYMBOL=- Hazardous or Poisonous Substance=cigarette smoking 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3522. SYMBOL=- Willing=agree 16 ==> Disease-Class=Asthma 16 conf:(1) 3523. SYMBOL=- Behavior Problem=smoked 16 ==> Disease-Class=Asthma 16 conf:( 1) 3524. SYMBOL=- Behavior Problem=abstinence 16 ==> Disease-Class=Asthma 16 co nf:(1) 3525. SYMBOL=> NUMERAL=5.0 16 ==> Disease-Class=Asthma 16 conf:(1) 3526. SYMBOL=> NUMERAL=30.0 16 ==> Disease-Class=Asthma 16 conf:(1) 3527. SYMBOL=> Quantitative Concept=one 16 ==> Disease-Class=Asthma 16 conf: (1) 3528. SYMBOL=< NUMERAL=60.0 16 ==> Disease-Class=Asthma 16 conf:(1) 3529. SYMBOL=< NUMERAL=8.0 16 ==> Disease-Class=Asthma 16 conf:(1) 3530. SYMBOL=>= Qualitative Concept=from 16 ==> Disease-Class=Asthma 16 conf :(1) 3531. SYMBOL=>= Functional Concept=using 16 ==> Disease-Class=Asthma 16 conf

:(1) 3532. SYMBOL== Disease or Syndrome=asthma 16 ==> Disease-Class=Asthma 16 con f:(1) 3533. NUMERAL=6.0 Functional Concept=systemic 16 ==> Disease-Class=Asthma 16 conf:(1) 3534. NUMERAL=6.0 Disease or Syndrome=bronchial asthma 16 ==> Disease-Class=Ast hma 16 conf:(1) 3535. NUMERAL=4.0 Diagnostic Procedure=fev1 16 ==> Disease-Class=Asthma 16 c onf:(1) 3536. NUMERAL=75.0 UNIT=% 16 ==> Disease-Class=Asthma 16 conf:(1) 3537. NUMERAL=80.0 Idea or Concept=eligible 16 ==> Disease-Class=Asthma 16 c onf:(1) 3538. NUMERAL=8.0 Spatial Concept=within 16 ==> Disease-Class=Asthma 16 conf :(1) 3539. NUMERAL=16.0 Laboratory or Test Result=pc20 16 ==> Disease-Class=Asthma 1 6 conf:(1) 3540. Quantitative Concept=or more Spatial Concept=within 16 ==> Disease-Class= Asthma 16 conf:(1) 3541. Quantitative Concept=exacerbation Body Space or Junction=oral 16 ==> Dise ase-Class=Asthma 16 conf:(1) 3542. Quantitative Concept=baseline Functional Concept=including 16 ==> Disease -Class=Asthma 16 conf:(1) 3543. Quantitative Concept=only Research Activity=study 16 ==> Disease-Class=As thma 16 conf:(1) 3544. Quantitative Concept=only Disease or Syndrome=asthma 16 ==> Disease-Class =Asthma 16 conf:(1) 3545. Quantitative Concept=pack Behavior Problem=smoked 16 ==> Disease-Class=As thma 16 conf:(1) 3546. Quantitative Concept=pack Behavior Problem=smoker 16 ==> Disease-Class=As thma 16 conf:(1) 3547. Quantitative Concept=present Disease or Syndrome=disease 16 ==> Disease-C lass=Asthma 16 conf:(1) 3548. Quantitative Concept=short Therapeutic or Preventive Procedure=treatment 16 ==> Disease-Class=Asthma 16 conf:(1) 3549. Quantitative Concept=dose Therapeutic or Preventive Procedure=treatment 1 6 ==> Disease-Class=Asthma 16 conf:(1) 3550. Quantitative Concept=dose Human=subjects 16 ==> Disease-Class=Asthma 16 conf:(1) 3551. Quantitative Concept=could Activity=interfere 16 ==> Disease-Class=Asthma 16 conf:(1) 3552. Laboratory or Test Result=pc20 Spatial Concept=within 16 ==> Disease-Clas s=Asthma 16 conf:(1) 3553. UNIT=% Qualitative Concept=improvement 16 ==> Disease-Class=Asthma 16 conf:(1) 3554. UNIT=% Laboratory Procedure=test 16 ==> Disease-Class=Asthma 16 conf:( 1) 3555. Organism Attribute=sex Age Group=age 16 ==> Disease-Class=Asthma 16 co nf:(1) 3556. Idea or Concept=continue Contraception=condom 16 ==> Disease-Class=Asthma 16 conf:(1) 3557. Research Activity=study Qualitative Concept=stable 16 ==> Disease-Class=A sthma 16 conf:(1) 3558. Research Activity=study Qualitative Concept=pre 16 ==> Disease-Class=Asth ma 16 conf:(1) 3559. Research Activity=study Functional Concept=used 16 ==> Disease-Class=Asth ma 16 conf:(1) 3560. Research Activity=study Spatial Concept=up to 16 ==> Disease-Class=Asthma 16 conf:(1) 3561. Research Activity=study Activity=taking 16 ==> Disease-Class=Asthma 16 conf:(1)

3562. Research Activity=randomization Diagnostic Procedure=fev1 16 ==> DiseaseClass=Asthma 16 conf:(1) 3563. Research Activity=gina Spatial Concept=global 16 ==> Disease-Class=Asthma 16 conf:(1) 3564. Research Activity=gina Mental Process=initiative 16 ==> Disease-Class=Ast hma 16 conf:(1) 3565. Qualitative Concept=negative Organism Function=urine pregnancy test 16 == > Disease-Class=Asthma 16 conf:(1) 3566. Qualitative Concept=positive Body System=skin 16 ==> Disease-Class=Asthma 16 conf:(1) 3567. Qualitative Concept=last Spatial Concept=out 16 ==> Disease-Class=Asthma 16 conf:(1) 3568. Qualitative Concept=last Human=subjects 16 ==> Disease-Class=Asthma 16 conf:(1) 3569. Qualitative Concept=significant Body Location or Region=hepatic 16 ==> Di sease-Class=Asthma 16 conf:(1) 3570. Qualitative Concept=improvement Diagnostic Procedure=fev1 16 ==> DiseaseClass=Asthma 16 conf:(1) 3571. Qualitative Concept=stable Therapeutic or Preventive Procedure=regimen 16 ==> Disease-Class=Asthma 16 conf:(1) 3572. Qualitative Concept=stable Individual Behavior=visit 16 ==> Disease-Class =Asthma 16 conf:(1) 3573. Qualitative Concept=longer Spatial Concept=within 16 ==> Disease-Class=As thma 16 conf:(1) 3574. Qualitative Concept=investigational Spatial Concept=within 16 ==> Disease -Class=Asthma 16 conf:(1) 3575. Therapeutic or Preventive Procedure=treatment Functional Concept=use of 1 6 ==> Disease-Class=Asthma 16 conf:(1) 3576. Therapeutic or Preventive Procedure=anti Disease or Syndrome=asthma 16 == > Disease-Class=Asthma 16 conf:(1) 3577. Therapeutic or Preventive Procedure=treated with Disease or Syndrome=asth ma 16 ==> Disease-Class=Asthma 16 conf:(1) 3578. Therapeutic or Preventive Procedure=administration Laboratory Procedure=s creening 16 ==> Disease-Class=Asthma 16 conf:(1) 3579. Therapeutic or Preventive Procedure=intubation Functional Concept=requiri ng 16 ==> Disease-Class=Asthma 16 conf:(1) 3580. Therapeutic or Preventive Procedure=surgically Pathologic Function=steril e 16 ==> Disease-Class=Asthma 16 conf:(1) 3581. Functional Concept=evidence of Individual Behavior=visit 16 ==> Disease-C lass=Asthma 16 conf:(1) 3582. Functional Concept=non Behavior Problem=smoking 16 ==> Disease-Class=Asth ma 16 conf:(1) 3583. Functional Concept=participate Finding=written 16 ==> Disease-Class=Asthm a 16 conf:(1) 3584. Functional Concept=use Body Space or Junction=oral 16 ==> Disease-Class=A sthma 16 conf:(1) 3585. Functional Concept=using Activity=inhaled 16 ==> Disease-Class=Asthma 16 conf:(1) 3586. Functional Concept=using Individual Behavior=visit 16 ==> Disease-Class=A sthma 16 conf:(1) 3587. Functional Concept=affect Human=subject 16 ==> Disease-Class=Asthma 16 conf:(1) 3588. Spatial Concept=within Hazardous or Poisonous Substance=tobacco products 16 ==> Disease-Class=Asthma 16 conf:(1) 3589. Spatial Concept=over Disease or Syndrome=asthma 16 ==> Disease-Class=Asth ma 16 conf:(1) 3590. Pathologic Function=sterile Contraception=condom 16 ==> Disease-Class=Ast hma 16 conf:(1) 3591. Disease or Syndrome=asthma Finding=good health 16 ==> Disease-Class=Asthm a 16 conf:(1)

3592. Disease or Syndrome=asthma MARK=] 16 ==> Disease-Class=Asthma 16 conf: (1) 3593. Disease or Syndrome=asthma Age Group=ages 16 ==> Disease-Class=Asthma 16 conf:(1) 3594. Disease or Syndrome=asthma Regulation or Law=questionnaire 16 ==> Disease -Class=Asthma 16 conf:(1) 3595. Disease or Syndrome=diseases Activity=inhaled 16 ==> Disease-Class=Asthma 16 conf:(1) 3596. Disease or Syndrome=disease Activity=put 16 ==> Disease-Class=Asthma 16 conf:(1) 3597. Body Substance=serum Immunologic Factor=ige 16 ==> Disease-Class=Asthma 1 6 conf:(1) 3598. Finding=written Human=subject 16 ==> Disease-Class=Asthma 16 conf:(1) 3599. MARK=& Individual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:( 1) 3600. Professional or Occupational Group=investigator Diagnostic Procedure=ecg 16 ==> Disease-Class=Asthma 16 conf:(1) 3601. Sign or Symptom=symptoms Diagnostic Procedure=fev1 16 ==> Disease-Class=A sthma 16 conf:(1) 3602. Individual Behavior=participation Human=subjects 16 ==> Disease-Class=Ast hma 16 conf:(1) 3603. Willing=willing Capacity=able 16 ==> Disease-Class=Asthma 16 conf:(1) 3604. Willing=willing Compliance=comply 16 ==> Disease-Class=Asthma 16 conf: (1) 3605. Patient or Disabled Group=patients SYMBOL=- Idea or Concept=acting 16 ==> Disease-Class=Asthma 16 conf:(1) 3606. Patient or Disabled Group=patients SYMBOL=> Individual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3607. Patient or Disabled Group=patients NUMERAL=1.0 Spatial Concept=within 16 ==> Disease-Class=Asthma 16 conf:(1) 3608. Patient or Disabled Group=patient SYMBOL=- Research Activity=study 16 ==> Disease-Class=Asthma 16 conf:(1) 3609. Patient or Disabled Group=patient UNIT=% Diagnostic Procedure=fev1 16 ==> Disease-Class=Asthma 16 conf:(1) 3610. Patient or Disabled Group=patient Spatial Concept=within Disease or Syndr ome=asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3611. Patient or Disabled Group=patient Professional or Occupational Group=inve stigator Individual Behavior=participation 16 ==> Disease-Class=Asthma 16 con f:(1) 3612. Health Care Activity=diagnosis Disease or Syndrome=asthma Sign or Symptom =symptoms 16 ==> Disease-Class=Asthma 16 conf:(1) 3613. Health Care Activity=hospitalization Therapeutic or Preventive Procedure= treatment Disease or Syndrome=asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3614. Health Care Activity=hospitalization Spatial Concept=within Individual Be havior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3615. Health Care Activity=hospitalization Laboratory Procedure=screening Indiv idual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3616. Health Care Activity=documented Spatial Concept=within Laboratory Procedu re=screening 16 ==> Disease-Class=Asthma 16 conf:(1) 3617. Temporal Concept=years NUMERAL=5.0 Spatial Concept=within 16 ==> DiseaseClass=Asthma 16 conf:(1) 3618. Temporal Concept=years NUMERAL=15.0 Research Activity=study 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3619. Temporal Concept=years NUMERAL=80.0 Idea or Concept=eligible 16 ==> Disea se-Class=Asthma 16 conf:(1) 3620. Temporal Concept=years NUMERAL=80.0 Research Activity=study 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3621. Temporal Concept=years Quantitative Concept=pack Behavior Problem=smoking 16 ==> Disease-Class=Asthma 16 conf:(1) 3622. Temporal Concept=years Organism Attribute=female Spatial Concept=between

16 ==> Disease-Class=Asthma 16 conf:(1) 3623. Temporal Concept=years Organism Attribute=female Human=subjects 16 ==> Di sease-Class=Asthma 16 conf:(1) 3624. Temporal Concept=after UNIT=% Functional Concept=increase 16 ==> DiseaseClass=Asthma 16 conf:(1) 3625. Temporal Concept=after Functional Concept=increase Diagnostic Procedure=f ev1 16 ==> Disease-Class=Asthma 16 conf:(1) 3626. Temporal Concept=prior to NO=no Individual Behavior=visit 16 ==> DiseaseClass=Asthma 16 conf:(1) 3627. Temporal Concept=prior to SYMBOL=>= NUMERAL=3.0 16 ==> Disease-Class=Asth ma 16 conf:(1) 3628. Temporal Concept=prior to NUMERAL=12.0 Disease or Syndrome=asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3629. Temporal Concept=prior to Quantitative Concept=exacerbation Individual Be havior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3630. Temporal Concept=prior to Quantitative Concept=short Idea or Concept=acti ng 16 ==> Disease-Class=Asthma 16 conf:(1) 3631. Temporal Concept=prior to Quantitative Concept=dose Research Activity=stu dy 16 ==> Disease-Class=Asthma 16 conf:(1) 3632. Temporal Concept=prior to Idea or Concept=acting Activity=inhaled 16 ==> Disease-Class=Asthma 16 conf:(1) 3633. Temporal Concept=prior to Functional Concept=use of Spatial Concept=withi n 16 ==> Disease-Class=Asthma 16 conf:(1) 3634. Temporal Concept=prior to Functional Concept=requiring Disease or Syndrom e=asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3635. Temporal Concept=prior to Disease or Syndrome=asthma Activity=inhaled 16 ==> Disease-Class=Asthma 16 conf:(1) 3636. Temporal Concept=weeks NUMERAL=4.0 Laboratory Procedure=screening 16 ==> Disease-Class=Asthma 16 conf:(1) 3637. Temporal Concept=weeks Quantitative Concept=exacerbation Spatial Concept= within 16 ==> Disease-Class=Asthma 16 conf:(1) 3638. Temporal Concept=weeks Quantitative Concept=exacerbation Disease or Syndr ome=asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3639. Temporal Concept=weeks Therapeutic or Preventive Procedure=treatment Spat ial Concept=within 16 ==> Disease-Class=Asthma 16 conf:(1) 3640. Temporal Concept=weeks Spatial Concept=within Human=subjects 16 ==> Disea se-Class=Asthma 16 conf:(1) 3641. Temporal Concept=months Pharmacologic Substance=corticosteroids NUMERAL=3 .0 16 ==> Disease-Class=Asthma 16 conf:(1) 3642. Temporal Concept=months SYMBOL=- Disease or Syndrome=asthma 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3643. Temporal Concept=months SYMBOL=> Spatial Concept=within 16 ==> Disease-Cl ass=Asthma 16 conf:(1) 3644. Temporal Concept=period Disease or Syndrome=asthma Sign or Symptom=run 16 ==> Disease-Class=Asthma 16 conf:(1) 3645. Temporal Concept=before NUMERAL=1.0 Individual Behavior=visit 16 ==> Dise ase-Class=Asthma 16 conf:(1) 3646. Temporal Concept=post Pharmacologic Substance=bronchodilator Diagnostic P rocedure=fev1 16 ==> Disease-Class=Asthma 16 conf:(1) 3647. Temporal Concept=concomitant Functional Concept=use of Activity=inhaled 1 6 ==> Disease-Class=Asthma 16 conf:(1) 3648. Intellectual Product=pack years NUMERAL=10.0 Spatial Concept=within 16 == > Disease-Class=Asthma 16 conf:(1) 3649. Intellectual Product=method Research Activity=study Functional Concept=us ing 16 ==> Disease-Class=Asthma 16 conf:(1) 3650. Clinical Attribute=parenteral Spatial Concept=within Individual Behavior= visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3651. Pharmacologic Substance=medication Research Activity=study Individual Beh avior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3652. Pharmacologic Substance=agonist SYMBOL=- UNIT=% 16 ==> Disease-Class=Asth

ma 16 conf:(1) 3653. Pharmacologic Substance=pef SYMBOL=> UNIT=% 16 ==> Disease-Class=Asthma 1 6 conf:(1) 3654. Pharmacologic Substance=pef UNIT=% Idea or Concept=predicted 16 ==> Disea se-Class=Asthma 16 conf:(1) 3655. Pharmacologic Substance=investigational drug Research Activity=study Spat ial Concept=within 16 ==> Disease-Class=Asthma 16 conf:(1) 3656. Pharmacologic Substance=bronchodilator SYMBOL=< UNIT=% 16 ==> Disease-Cla ss=Asthma 16 conf:(1) 3657. Pharmacologic Substance=bronchodilator SYMBOL=< Diagnostic Procedure=fev1 16 ==> Disease-Class=Asthma 16 conf:(1) 3658. Pharmacologic Substance=bronchodilator SYMBOL=>= UNIT=% 16 ==> Disease-Cl ass=Asthma 16 conf:(1) 3659. NO=not SYMBOL=- Idea or Concept=acting 16 ==> Disease-Class=Asthma 16 conf:(1) 3660. NO=not SYMBOL=- Spatial Concept=within 16 ==> Disease-Class=Asthma 16 conf:(1) 3661. NO=not SYMBOL=- Professional or Occupational Group=investigator 16 ==> Di sease-Class=Asthma 16 conf:(1) 3662. NO=not SYMBOL=>= NUMERAL=1.0 16 ==> Disease-Class=Asthma 16 conf:(1) 3663. NO=not NUMERAL=1.0 Laboratory Procedure=screening 16 ==> Disease-Class=As thma 16 conf:(1) 3664. NO=not Idea or Concept=eligible Human=subject 16 ==> Disease-Class=Asthma 16 conf:(1) 3665. NO=not Functional Concept=using Organism Function=childbearing 16 ==> Dis ease-Class=Asthma 16 conf:(1) 3666. NO=not Functional Concept=using Contraception=contraception 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3667. NO=not Disease or Syndrome=asthma Human=subject 16 ==> Disease-Class=Asth ma 16 conf:(1) 3668. SYMBOL=- NUMERAL=2.0 Activity=inhaled 16 ==> Disease-Class=Asthma 16 c onf:(1) 3669. SYMBOL=- NUMERAL=12.0 Laboratory Procedure=screening 16 ==> Disease-Class =Asthma 16 conf:(1) 3670. SYMBOL=- NUMERAL=??????2 Idea or Concept=acting 16 ==> Disease-Class=Asth ma 16 conf:(1) 3671. SYMBOL=- UNIT=% Idea or Concept=acting 16 ==> Disease-Class=Asthma 16 conf:(1) 3672. SYMBOL=- UNIT=% Organism Function=inhalation 16 ==> Disease-Class=Asthma 16 conf:(1) 3673. SYMBOL=- Organism Attribute=female Age Group=aged 16 ==> Disease-Class=As thma 16 conf:(1) 3674. SYMBOL=- Research Activity=study Finding=lives 16 ==> Disease-Class=Asthm a 16 conf:(1) 3675. SYMBOL=- Research Activity=study Sign or Symptom=run 16 ==> Disease-Class =Asthma 16 conf:(1) 3676. SYMBOL=- Research Activity=study Body Space or Junction=oral 16 ==> Disea se-Class=Asthma 16 conf:(1) 3677. SYMBOL=- Research Activity=study Capacity=ability 16 ==> Disease-Class=As thma 16 conf:(1) 3678. SYMBOL=- Qualitative Concept=beta2 Activity=inhaled 16 ==> Disease-Class= Asthma 16 conf:(1) 3679. SYMBOL=- Functional Concept=required Disease or Syndrome=asthma 16 ==> Di sease-Class=Asthma 16 conf:(1) 3680. SYMBOL=- Professional or Occupational Group=investigator Individual Behav ior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3681. SYMBOL=> NUMERAL=1.0 Individual Behavior=visit 16 ==> Disease-Class=Asthm a 16 conf:(1) 3682. SYMBOL=< Laboratory or Test Result=pc20 UNIT=% 16 ==> Disease-Class=Asthm a 16 conf:(1)

3683. SYMBOL=>= NUMERAL=4.0 Laboratory Procedure=screening 16 ==> Disease-Class =Asthma 16 conf:(1) 3684. SYMBOL=>= NUMERAL=80.0 Idea or Concept=predicted 16 ==> Disease-Class=Ast hma 16 conf:(1) 3685. SYMBOL=>= UNIT=% Functional Concept=increase 16 ==> Disease-Class=Asthma 16 conf:(1) 3686. SYMBOL=>= Idea or Concept=acting Laboratory Procedure=screening 16 ==> Di sease-Class=Asthma 16 conf:(1) 3687. NUMERAL=10.0 Quantitative Concept=pack Behavior Problem=smoking 16 ==> Di sease-Class=Asthma 16 conf:(1) 3688. NUMERAL=10.0 Therapeutic or Preventive Procedure=ex Finding=smoking histo ry 16 ==> Disease-Class=Asthma 16 conf:(1) 3689. NUMERAL=30.0 Spatial Concept=within Laboratory Procedure=screening 16 ==> Disease-Class=Asthma 16 conf:(1) 3690. NUMERAL=3.0 Qualitative Concept=last Disease or Syndrome=asthma 16 ==> Di sease-Class=Asthma 16 conf:(1) 3691. NUMERAL=1.0 Disease or Syndrome=asthma Body Space or Junction=oral 16 ==> Disease-Class=Asthma 16 conf:(1) 3692. NUMERAL=15.0 Idea or Concept=eligible Research Activity=study 16 ==> Dise ase-Class=Asthma 16 conf:(1) 3693. NUMERAL=50.0 UNIT=% Diagnostic Procedure=fev1 16 ==> Disease-Class=Asthma 16 conf:(1) 3694. NUMERAL=80.0 Idea or Concept=eligible Research Activity=study 16 ==> Dise ase-Class=Asthma 16 conf:(1) 3695. NUMERAL=80.0 Idea or Concept=eligible Age Group=ages 16 ==> Disease-Class =Asthma 16 conf:(1) 3696. NUMERAL=80.0 Research Activity=study Age Group=ages 16 ==> Disease-Class= Asthma 16 conf:(1) 3697. Quantitative Concept=exacerbation Spatial Concept=within Laboratory Proce dure=screening 16 ==> Disease-Class=Asthma 16 conf:(1) 3698. Quantitative Concept=short Idea or Concept=acting Therapeutic or Preventi ve Procedure=treatment 16 ==> Disease-Class=Asthma 16 conf:(1) 3699. Quantitative Concept=short Idea or Concept=acting Laboratory Procedure=sc reening 16 ==> Disease-Class=Asthma 16 conf:(1) 3700. Quantitative Concept=normal value Idea or Concept=predicted Diagnostic Pr ocedure=fev1 16 ==> Disease-Class=Asthma 16 conf:(1) 3701. UNIT=% Qualitative Concept=improvement Diagnostic Procedure=fev1 16 ==> D isease-Class=Asthma 16 conf:(1) 3702. Idea or Concept=predicted Diagnostic Procedure=fev1 Human=subjects 16 ==> Disease-Class=Asthma 16 conf:(1) 3703. Idea or Concept=continue Willing=agree Contraception=condom 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3704. Idea or Concept=acting Spatial Concept=within Activity=inhaled 16 ==> Dis ease-Class=Asthma 16 conf:(1) 3705. Idea or Concept=acting Activity=inhaled Body Space or Junction=oral 16 == > Disease-Class=Asthma 16 conf:(1) 3706. Research Activity=study Qualitative Concept=from Laboratory Procedure=scr eening 16 ==> Disease-Class=Asthma 16 conf:(1) 3707. Research Activity=study Qualitative Concept=from Human=subjects 16 ==> Di sease-Class=Asthma 16 conf:(1) 3708. Research Activity=study Qualitative Concept=has Spatial Concept=within 16 ==> Disease-Class=Asthma 16 conf:(1) 3709. Research Activity=study Functional Concept=using Willing=agree 16 ==> Dis ease-Class=Asthma 16 conf:(1) 3710. Research Activity=study Spatial Concept=within Activity=inhaled 16 ==> Di sease-Class=Asthma 16 conf:(1) 3711. Research Activity=study Disease or Syndrome=asthma Human=subject 16 ==> D isease-Class=Asthma 16 conf:(1) 3712. Research Activity=study Disease or Syndrome=disease Human=subject 16 ==> Disease-Class=Asthma 16 conf:(1)

3713. Research Activity=study Activity=interfere Individual Behavior=participat ion 16 ==> Disease-Class=Asthma 16 conf:(1) 3714. Research Activity=study Willing=willing Capacity=able to 16 ==> Disease-C lass=Asthma 16 conf:(1) 3715. Research Activity=gina Spatial Concept=global Disease or Syndrome=asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3716. Research Activity=gina Spatial Concept=global Mental Process=initiative 1 6 ==> Disease-Class=Asthma 16 conf:(1) 3717. Research Activity=gina Disease or Syndrome=asthma Mental Process=initiati ve 16 ==> Disease-Class=Asthma 16 conf:(1) 3718. Qualitative Concept=acceptable Functional Concept=using Contraception=con traception 16 ==> Disease-Class=Asthma 16 conf:(1) 3719. Qualitative Concept=has Disease or Syndrome=asthma Human=subject 16 ==> D isease-Class=Asthma 16 conf:(1) 3720. Qualitative Concept=at risk Professional or Occupational Group=investigat or Activity=put 16 ==> Disease-Class=Asthma 16 conf:(1) 3721. Functional Concept=use of Disease or Syndrome=diseases Activity=inhaled 1 6 ==> Disease-Class=Asthma 16 conf:(1) 3722. Spatial Concept=within Disease or Syndrome=asthma Human=subjects 16 ==> D isease-Class=Asthma 16 conf:(1) 3723. Disease or Syndrome=asthma Activity=inhaled Body Space or Junction=oral 1 6 ==> Disease-Class=Asthma 16 conf:(1) 3724. Activity=inhaled Body Space or Junction=oral Individual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3725. Patient or Disabled Group=patients Temporal Concept=prior to NUMERAL=1.0 Individual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3726. Patient or Disabled Group=patients NUMERAL=1.0 Spatial Concept=within Ind ividual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3727. Patient or Disabled Group=patient Idea or Concept=opinion Research Activi ty=study Professional or Occupational Group=investigator 16 ==> Disease-Class=As thma 16 conf:(1) 3728. Patient or Disabled Group=patient Research Activity=study Professional or Occupational Group=investigator Individual Behavior=participation 16 ==> Diseas e-Class=Asthma 16 conf:(1) 3729. Health Care Activity=diagnosis SYMBOL=>= NUMERAL=6.0 Disease or Syndrome= asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3730. Temporal Concept=years NUMERAL=15.0 Idea or Concept=eligible Research Act ivity=study 16 ==> Disease-Class=Asthma 16 conf:(1) 3731. Temporal Concept=years NUMERAL=80.0 Idea or Concept=eligible Research Act ivity=study 16 ==> Disease-Class=Asthma 16 conf:(1) 3732. Temporal Concept=years NUMERAL=80.0 Idea or Concept=eligible Age Group=ag es 16 ==> Disease-Class=Asthma 16 conf:(1) 3733. Temporal Concept=years NUMERAL=80.0 Research Activity=study Age Group=age s 16 ==> Disease-Class=Asthma 16 conf:(1) 3734. Temporal Concept=after SYMBOL=- UNIT=% Diagnostic Procedure=fev1 16 ==> D isease-Class=Asthma 16 conf:(1) 3735. Temporal Concept=prior to SYMBOL=>= Laboratory Procedure=screening Activi ty=inhaled 16 ==> Disease-Class=Asthma 16 conf:(1) 3736. Temporal Concept=prior to NUMERAL=1.0 Therapeutic or Preventive Procedure =treatment Individual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3737. Temporal Concept=prior to NUMERAL=1.0 Spatial Concept=within Laboratory P rocedure=screening 16 ==> Disease-Class=Asthma 16 conf:(1) 3738. Temporal Concept=prior to Quantitative Concept=exacerbation Spatial Conce pt=within Disease or Syndrome=asthma 16 ==> Disease-Class=Asthma 16 conf:(1) 3739. Temporal Concept=prior to Therapeutic or Preventive Procedure=treatment S patial Concept=within Individual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3740. Clinical Attribute=parenteral Spatial Concept=within Body Space or Juncti on=oral Individual Behavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3741. SYMBOL=- Idea or Concept=opinion Research Activity=study Professional or

Occupational Group=investigator 16 ==> Disease-Class=Asthma 16 conf:(1) 3742. SYMBOL=- Spatial Concept=within Activity=inhaled Body Space or Junction=o ral 16 ==> Disease-Class=Asthma 16 conf:(1) 3743. SYMBOL=- Spatial Concept=within Body Space or Junction=oral Individual Be havior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3744. SYMBOL=< Quantitative Concept=ml Laboratory or Test Result=pc20 Organic C hemical=methacholine 16 ==> Disease-Class=Asthma 16 conf:(1) 3745. SYMBOL=>= NUMERAL=80.0 UNIT=% Idea or Concept=predicted 16 ==> Disease-Cl ass=Asthma 16 conf:(1) 3746. NUMERAL=1.0 Functional Concept=use of Spatial Concept=within Individual B ehavior=visit 16 ==> Disease-Class=Asthma 16 conf:(1) 3747. NUMERAL=1.0 Spatial Concept=within Activity=inhaled Individual Behavior=v isit 16 ==> Disease-Class=Asthma 16 conf:(1) 3748. NUMERAL=1.0 Spatial Concept=within Individual Behavior=visit Human=subjec t 16 ==> Disease-Class=Asthma 16 conf:(1) 3749. NUMERAL=80.0 Idea or Concept=eligible Research Activity=study Age Group=a ges 16 ==> Disease-Class=Asthma 16 conf:(1) 3750. Quantitative Concept=normal value UNIT=% Idea or Concept=predicted Diagno stic Procedure=fev1 16 ==> Disease-Class=Asthma 16 conf:(1) 3751. Research Activity=gina Spatial Concept=global Disease or Syndrome=asthma Mental Process=initiative 16 ==> Disease-Class=Asthma 16 conf:(1) 3752. Temporal Concept=years NUMERAL=80.0 Idea or Concept=eligible Research Act ivity=study Age Group=ages 16 ==> Disease-Class=Asthma 16 conf:(1) 3753. Patient or Disabled Group=outpatient 15 ==> Disease-Class=Asthma 15 co nf:(1) 3754. Health Care Activity=schedule 15 ==> Disease-Class=Asthma 15 conf:(1) 3755. Health Care Activity=hospitalizations 15 ==> Disease-Class=Asthma 15 c onf:(1) 3756. Temporal Concept=per year 15 ==> Disease-Class=Asthma 15 conf:(1) 3757. Temporal Concept=phase 15 ==> Disease-Class=Asthma 15 conf:(1) 3758. Temporal Concept=at time 15 ==> Disease-Class=Asthma 15 conf:(1) 3759. Intellectual Product=cards 15 ==> Disease-Class=Asthma 15 conf:(1) 3760. NUMERAL=25.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3761. NUMERAL=35.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3762. Quantitative Concept=daily dose 15 ==> Disease-Class=Asthma 15 conf:(1 ) 3763. Organism Attribute=gender 15 ==> Disease-Class=Asthma 15 conf:(1) 3764. Idea or Concept=historical 15 ==> Disease-Class=Asthma 15 conf:(1) 3765. Idea or Concept=second 15 ==> Disease-Class=Asthma 15 conf:(1) 3766. Qualitative Concept=worsening 15 ==> Disease-Class=Asthma 15 conf:(1) 3767. Population Group=minor 15 ==> Disease-Class=Asthma 15 conf:(1) 3768. Therapeutic or Preventive Procedure=mechanical ventilation 15 ==> Disease -Class=Asthma 15 conf:(1) 3769. Therapeutic or Preventive Procedure=procedure 15 ==> Disease-Class=Asthma 15 conf:(1) 3770. Therapeutic or Preventive Procedure=sterilized 15 ==> Disease-Class=Asthm a 15 conf:(1) 3771. Functional Concept=reaction 15 ==> Disease-Class=Asthma 15 conf:(1) 3772. Functional Concept=measured 15 ==> Disease-Class=Asthma 15 conf:(1) 3773. Functional Concept=plan 15 ==> Disease-Class=Asthma 15 conf:(1) 3774. Spatial Concept=access 15 ==> Disease-Class=Asthma 15 conf:(1) 3775. Organism Function=child bearing 15 ==> Disease-Class=Asthma 15 conf:(1 ) 3776. Organism Function=bearing 15 ==> Disease-Class=Asthma 15 conf:(1) 3777. Disease or Syndrome=moderate persistent asthma 15 ==> Disease-Class=Asthm a 15 conf:(1) 3778. Disease or Syndrome=upper respiratory tract infection 15 ==> Disease-Clas s=Asthma 15 conf:(1) 3779. Laboratory Procedure=tested 15 ==> Disease-Class=Asthma 15 conf:(1) 3780. Laboratory Procedure=screen 15 ==> Disease-Class=Asthma 15 conf:(1)

3781. Finding=exacerbation of asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 3782. Finding=responsible 15 ==> Disease-Class=Asthma 15 conf:(1) 3783. Biologically Active Substance=lactose 15 ==> Disease-Class=Asthma 15 c onf:(1) 3784. Conceptual Entity=list 15 ==> Disease-Class=Asthma 15 conf:(1) 3785. Age Group=adults 15 ==> Disease-Class=Asthma 15 conf:(1) 3786. Manufactured Object=electronic 15 ==> Disease-Class=Asthma 15 conf:(1) 3787. Physiologic Function=change 15 ==> Disease-Class=Asthma 15 conf:(1) 3788. Daily or Recreational Activity=speaking 15 ==> Disease-Class=Asthma 15 conf:(1) 3789. Event=event 15 ==> Disease-Class=Asthma 15 conf:(1) 3790. Invertebrate=house dust mite 15 ==> Disease-Class=Asthma 15 conf:(1) 3791. Other Study=another clinical trial 15 ==> Disease-Class=Asthma 15 conf :(1) 3792. Patient or Disabled Group=patients Temporal Concept=before 15 ==> Disease -Class=Asthma 15 conf:(1) 3793. Patient or Disabled Group=patients Quantitative Concept=all 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3794. Patient or Disabled Group=patient Temporal Concept=months 15 ==> DiseaseClass=Asthma 15 conf:(1) 3795. Patient or Disabled Group=patient Qualitative Concept=at risk 15 ==> Dise ase-Class=Asthma 15 conf:(1) 3796. Patient or Disabled Group=patient Activity=inhaled 15 ==> Disease-Class=A sthma 15 conf:(1) 3797. Health Care Activity=diagnosis Laboratory Procedure=screening 15 ==> Dise ase-Class=Asthma 15 conf:(1) 3798. Health Care Activity=physical examination Disease or Syndrome=asthma 15 = => Disease-Class=Asthma 15 conf:(1) 3799. Health Care Activity=prescribed Individual Behavior=visit 15 ==> DiseaseClass=Asthma 15 conf:(1) 3800. Health Care Activity=hospitalization SYMBOL=- 15 ==> Disease-Class=Asthma 15 conf:(1) 3801. Health Care Activity=meet SYMBOL=- 15 ==> Disease-Class=Asthma 15 conf :(1) 3802. Health Care Activity=drug administration Temporal Concept=day 15 ==> Dise ase-Class=Asthma 15 conf:(1) 3803. Temporal Concept=years NUMERAL=20.0 15 ==> Disease-Class=Asthma 15 con f:(1) 3804. Temporal Concept=duration SYMBOL=>= 15 ==> Disease-Class=Asthma 15 con f:(1) 3805. Temporal Concept=days Disease or Syndrome=asthma 15 ==> Disease-Class=Ast hma 15 conf:(1) 3806. Temporal Concept=current Qualitative Concept=other 15 ==> Disease-Class=A sthma 15 conf:(1) 3807. Temporal Concept=history of Idea or Concept=opinion 15 ==> Disease-Class= Asthma 15 conf:(1) 3808. Temporal Concept=history of Body Location or Region=hepatic 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3809. Temporal Concept=prior to SYMBOL=< 15 ==> Disease-Class=Asthma 15 conf :(1) 3810. Temporal Concept=prior to Qualitative Concept=significant 15 ==> DiseaseClass=Asthma 15 conf:(1) 3811. Temporal Concept=prior to Individual Behavior=participation 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3812. Temporal Concept=months NUMERAL=2.0 15 ==> Disease-Class=Asthma 15 con f:(1) 3813. Temporal Concept=months Quantitative Concept=three 15 ==> Disease-Class=A sthma 15 conf:(1) 3814. Temporal Concept=months Diagnostic Procedure=fev1 15 ==> Disease-Class=As thma 15 conf:(1)

3815. Temporal Concept=year Intellectual Product=pack years 15 ==> Disease-Clas s=Asthma 15 conf:(1) 3816. Temporal Concept=year Qualitative Concept=last 15 ==> Disease-Class=Asthm a 15 conf:(1) 3817. Temporal Concept=period Diagnostic Procedure=fev1 15 ==> Disease-Class=As thma 15 conf:(1) 3818. Temporal Concept=daily Activity=inhaled 15 ==> Disease-Class=Asthma 15 conf:(1) 3819. Temporal Concept=month Quantitative Concept=exacerbation 15 ==> Disease-C lass=Asthma 15 conf:(1) 3820. Temporal Concept=day SYMBOL=<= 15 ==> Disease-Class=Asthma 15 conf:(1) 3821. Temporal Concept=day Pathologic Function=sterile 15 ==> Disease-Class=Ast hma 15 conf:(1) 3822. Temporal Concept=day Disease or Syndrome=asthma 15 ==> Disease-Class=Asth ma 15 conf:(1) 3823. Temporal Concept=currently Disease or Syndrome=asthma 15 ==> Disease-Clas s=Asthma 15 conf:(1) 3824. Temporal Concept=preceding NUMERAL=3.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3825. Temporal Concept=at the time Laboratory Procedure=screening 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3826. Temporal Concept=concomitant NO=exclusion criteria 15 ==> Disease-Class=A sthma 15 conf:(1) 3827. Temporal Concept=episode Disease or Syndrome=asthma 15 ==> Disease-Class= Asthma 15 conf:(1) 3828. Intellectual Product=methods Qualitative Concept=acceptable 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3829. Intellectual Product=criteria UNIT=% 15 ==> Disease-Class=Asthma 15 co nf:(1) 3830. Intellectual Product=method Idea or Concept=continue 15 ==> Disease-Class =Asthma 15 conf:(1) 3831. Intellectual Product=method Finding=sexually active 15 ==> Disease-Class= Asthma 15 conf:(1) 3832. Intellectual Product=until SYMBOL=- 15 ==> Disease-Class=Asthma 15 con f:(1) 3833. Intellectual Product=upon Individual Behavior=visit 15 ==> Disease-Class= Asthma 15 conf:(1) 3834. Clinical Attribute=height Age Group=age 15 ==> Disease-Class=Asthma 15 conf:(1) 3835. Clinical Attribute=response Qualitative Concept=positive 15 ==> Disease-C lass=Asthma 15 conf:(1) 3836. Clinical Attribute=parenteral Functional Concept=use of 15 ==> Disease-Cl ass=Asthma 15 conf:(1) 3837. Pharmacologic Substance=albuterol Quantitative Concept=mcg 15 ==> Disease -Class=Asthma 15 conf:(1) 3838. Pharmacologic Substance=albuterol Individual Behavior=visit 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3839. Pharmacologic Substance=corticosteroid Laboratory Procedure=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 3840. Pharmacologic Substance=steroids SYMBOL=- 15 ==> Disease-Class=Asthma 15 conf:(1) 3841. Pharmacologic Substance=steroids Qualitative Concept=last 15 ==> DiseaseClass=Asthma 15 conf:(1) 3842. Pharmacologic Substance=steroids Disease or Syndrome=diseases 15 ==> Dise ase-Class=Asthma 15 conf:(1) 3843. Pharmacologic Substance=agonist Diagnostic Procedure=fev1 15 ==> DiseaseClass=Asthma 15 conf:(1) 3844. Pharmacologic Substance=pef SYMBOL=- 15 ==> Disease-Class=Asthma 15 co nf:(1) 3845. Pharmacologic Substance=drug Individual Behavior=visit 15 ==> Disease-Cla

ss=Asthma 15 conf:(1) 3846. Pharmacologic Substance=salbutamol Research Activity=study 15 ==> Disease -Class=Asthma 15 conf:(1) 3847. Pharmacologic Substance=salbutamol Laboratory Procedure=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 3848. Pharmacologic Substance=steroid SYMBOL=- 15 ==> Disease-Class=Asthma 15 conf:(1) 3849. Pharmacologic Substance=fluticasone SYMBOL=>= 15 ==> Disease-Class=Asthma 15 conf:(1) 3850. NO=no NUMERAL=6.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3851. NO=no NUMERAL=1.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3852. NO=no Therapeutic or Preventive Procedure=treatment 15 ==> Disease-Class= Asthma 15 conf:(1) 3853. NO=no Functional Concept=use of 15 ==> Disease-Class=Asthma 15 conf:(1 ) 3854. NO=exclusion criteria Functional Concept=use of 15 ==> Disease-Class=Asth ma 15 conf:(1) 3855. NO=excluded Disease or Syndrome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 3856. NO=excluded Human=subjects 15 ==> Disease-Class=Asthma 15 conf:(1) 3857. NO=not NUMERAL=2.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3858. NO=not Quantitative Concept=short 15 ==> Disease-Class=Asthma 15 conf: (1) 3859. NO=not Quantitative Concept=dose 15 ==> Disease-Class=Asthma 15 conf:( 1) 3860. NO=not Organism Function=pregnant 15 ==> Disease-Class=Asthma 15 conf: (1) 3861. SYMBOL=- NUMERAL=90.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3862. SYMBOL=- NUMERAL=75.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3863. SYMBOL=- Quantitative Concept=only 15 ==> Disease-Class=Asthma 15 conf :(1) 3864. SYMBOL=- UNIT=m2 15 ==> Disease-Class=Asthma 15 conf:(1) 3865. SYMBOL=- Qualitative Concept=regular 15 ==> Disease-Class=Asthma 15 co nf:(1) 3866. SYMBOL=- Population Group=cohort 15 ==> Disease-Class=Asthma 15 conf:( 1) 3867. SYMBOL=- Therapeutic or Preventive Procedure=administration 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3868. SYMBOL=- Functional Concept=start 15 ==> Disease-Class=Asthma 15 conf: (1) 3869. SYMBOL=- Pathologic Function=sterile 15 ==> Disease-Class=Asthma 15 co nf:(1) 3870. SYMBOL=- Sign or Symptom=conditions 15 ==> Disease-Class=Asthma 15 con f:(1) 3871. SYMBOL=- Medical Device=lead 15 ==> Disease-Class=Asthma 15 conf:(1) 3872. SYMBOL=- Allergy=allergic 15 ==> Disease-Class=Asthma 15 conf:(1) 3873. SYMBOL=> NUMERAL=60.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3874. SYMBOL=> Quantitative Concept=two 15 ==> Disease-Class=Asthma 15 conf: (1) 3875. SYMBOL=>= NUMERAL=10.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3876. SYMBOL=>= NUMERAL=30.0 15 ==> Disease-Class=Asthma 15 conf:(1) 3877. SYMBOL=>= Disease or Syndrome=bronchial asthma 15 ==> Disease-Class=Asthm a 15 conf:(1) 3878. NUMERAL=5.0 Quantitative Concept=pack 15 ==> Disease-Class=Asthma 15 c onf:(1) 3879. NUMERAL=30.0 Qualitative Concept=last 15 ==> Disease-Class=Asthma 15 c onf:(1) 3880. NUMERAL=2.0 Qualitative Concept=last 15 ==> Disease-Class=Asthma 15 co nf:(1) 3881. NUMERAL=4.0 Idea or Concept=acting 15 ==> Disease-Class=Asthma 15 conf

:(1) 3882. NUMERAL=4.0 Research Activity=entry 15 ==> Disease-Class=Asthma 15 con f:(1) 3883. NUMERAL=4.0 Qualitative Concept=beta 15 ==> Disease-Class=Asthma 15 co nf:(1) 3884. NUMERAL=4.0 Qualitative Concept=stable 15 ==> Disease-Class=Asthma 15 conf:(1) 3885. NUMERAL=4.0 Disease or Syndrome=respiratory tract infection 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3886. NUMERAL=3.0 Therapeutic or Preventive Procedure=treated with 15 ==> Disea se-Class=Asthma 15 conf:(1) 3887. NUMERAL=1.0 Quantitative Concept=dose 15 ==> Disease-Class=Asthma 15 c onf:(1) 3888. NUMERAL=1.0 Idea or Concept=predicted 15 ==> Disease-Class=Asthma 15 c onf:(1) 3889. NUMERAL=1.0 Functional Concept=non 15 ==> Disease-Class=Asthma 15 conf :(1) 3890. NUMERAL=1.0 Functional Concept=used 15 ==> Disease-Class=Asthma 15 con f:(1) 3891. NUMERAL=12.0 Medical Device=lead 15 ==> Disease-Class=Asthma 15 conf:( 1) 3892. NUMERAL=12.0 Human=subjects 15 ==> Disease-Class=Asthma 15 conf:(1) 3893. NUMERAL=50.0 Idea or Concept=predicted 15 ==> Disease-Class=Asthma 15 conf:(1) 3894. NUMERAL=8.0 Laboratory or Test Result=pc20 15 ==> Disease-Class=Asthma 15 conf:(1) 3895. NUMERAL=8.0 Research Activity=study 15 ==> Disease-Class=Asthma 15 con f:(1) 3896. NUMERAL=1000.0 Quantitative Concept=mcg 15 ==> Disease-Class=Asthma 15 conf:(1) 3897. NUMERAL=16.0 Quantitative Concept=ml 15 ==> Disease-Class=Asthma 15 co nf:(1) 3898. Quantitative Concept=exacerbation Disease or Syndrome=acute asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 3899. Quantitative Concept=pack Behavior Problem=smokers 15 ==> Disease-Class=A sthma 15 conf:(1) 3900. Quantitative Concept=short Research Activity=study 15 ==> Disease-Class=A sthma 15 conf:(1) 3901. Quantitative Concept=short Functional Concept=use 15 ==> Disease-Class=As thma 15 conf:(1) 3902. Quantitative Concept=dose Disease or Syndrome=asthma 15 ==> Disease-Class =Asthma 15 conf:(1) 3903. Quantitative Concept=puffs Diagnostic Procedure=fev1 15 ==> Disease-Class =Asthma 15 conf:(1) 3904. Quantitative Concept=half Finding=lives 15 ==> Disease-Class=Asthma 15 conf:(1) 3905. Quantitative Concept=doses Activity=inhaled 15 ==> Disease-Class=Asthma 1 5 conf:(1) 3906. UNIT=% Qualitative Concept=positive 15 ==> Disease-Class=Asthma 15 con f:(1) 3907. UNIT=% Sign or Symptom=run 15 ==> Disease-Class=Asthma 15 conf:(1) 3908. UNIT=time Human=subject 15 ==> Disease-Class=Asthma 15 conf:(1) 3909. Organism Attribute=female Age Group=ages 15 ==> Disease-Class=Asthma 15 conf:(1) 3910. Organism Attribute=female Contraception=birth control 15 ==> Disease-Clas s=Asthma 15 conf:(1) 3911. Organism Attribute=females Qualitative Concept=negative 15 ==> Disease-Cl ass=Asthma 15 conf:(1) 3912. Idea or Concept=predicted Activity=inhaled 15 ==> Disease-Class=Asthma 15 conf:(1)

3913. Idea or Concept=exception Disease or Syndrome=asthma 15 ==> Disease-Class =Asthma 15 conf:(1) 3914. Idea or Concept=opinion Qualitative Concept=at risk 15 ==> Disease-Class= Asthma 15 conf:(1) 3915. Idea or Concept=opinion Capacity=ability 15 ==> Disease-Class=Asthma 15 conf:(1) 3916. Research Activity=study Population Group=sexual partner 15 ==> Disease-Cl ass=Asthma 15 conf:(1) 3917. Research Activity=study Family Group=partner 15 ==> Disease-Class=Asthma 15 conf:(1) 3918. Research Activity=study Capacity=unable 15 ==> Disease-Class=Asthma 15 conf:(1) 3919. Research Activity=randomization Human=subject 15 ==> Disease-Class=Asthma 15 conf:(1) 3920. Research Activity=trial Qualitative Concept=has 15 ==> Disease-Class=Asth ma 15 conf:(1) 3921. Qualitative Concept=inclusion criteria Human=subjects 15 ==> Disease-Clas s=Asthma 15 conf:(1) 3922. Qualitative Concept=other Allergy=allergy 15 ==> Disease-Class=Asthma 15 conf:(1) 3923. Qualitative Concept=positive Laboratory Procedure=screening 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3924. Qualitative Concept=beta Functional Concept=use 15 ==> Disease-Class=Asth ma 15 conf:(1) 3925. Qualitative Concept=severe Disease or Syndrome=asthma 15 ==> Disease-Clas s=Asthma 15 conf:(1) 3926. Qualitative Concept=from Finding=written 15 ==> Disease-Class=Asthma 15 conf:(1) 3927. Qualitative Concept=last Therapeutic or Preventive Procedure=treatment 15 ==> Disease-Class=Asthma 15 conf:(1) 3928. Qualitative Concept=significant Disease or Syndrome=disease 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3929. Qualitative Concept=significant Disease or Syndrome=disease or disorder 1 5 ==> Disease-Class=Asthma 15 conf:(1) 3930. Qualitative Concept=clinical Disease or Syndrome=asthma 15 ==> Disease-Cl ass=Asthma 15 conf:(1) 3931. Qualitative Concept=minimum Disease or Syndrome=asthma 15 ==> Disease-Cla ss=Asthma 15 conf:(1) 3932. Qualitative Concept=known Allergy=hypersensitivity 15 ==> Disease-Class=A sthma 15 conf:(1) 3933. Qualitative Concept=longer Finding=lives 15 ==> Disease-Class=Asthma 15 conf:(1) 3934. Qualitative Concept=perform Capacity=able to 15 ==> Disease-Class=Asthma 15 conf:(1) 3935. Qualitative Concept=pre Individual Behavior=visit 15 ==> Disease-Class=As thma 15 conf:(1) 3936. Qualitative Concept=contraindications Functional Concept=use of 15 ==> Di sease-Class=Asthma 15 conf:(1) 3937. Qualitative Concept=at risk Individual Behavior=participation 15 ==> Dise ase-Class=Asthma 15 conf:(1) 3938. Population Group=women Functional Concept=use 15 ==> Disease-Class=Asthma 15 conf:(1) 3939. Population Group=guardian Regulation or Law=informed consent 15 ==> Disea se-Class=Asthma 15 conf:(1) 3940. Population Group=race Age Group=age 15 ==> Disease-Class=Asthma 15 con f:(1) 3941. Therapeutic or Preventive Procedure=anti Activity=inhaled 15 ==> DiseaseClass=Asthma 15 conf:(1) 3942. Therapeutic or Preventive Procedure=administration Human=subject 15 ==> D isease-Class=Asthma 15 conf:(1)

3943. Therapeutic or Preventive Procedure=procedures Professional or Occupation al Group=investigator 15 ==> Disease-Class=Asthma 15 conf:(1) 3944. Therapeutic or Preventive Procedure=rescue Functional Concept=use of 15 = => Disease-Class=Asthma 15 conf:(1) 3945. Functional Concept=requiring Body Space or Junction=oral 15 ==> Disease-C lass=Asthma 15 conf:(1) 3946. Functional Concept=participate Activity=put 15 ==> Disease-Class=Asthma 1 5 conf:(1) 3947. Functional Concept=use Organism Function=childbearing 15 ==> Disease-Clas s=Asthma 15 conf:(1) 3948. Functional Concept=use Human=subject 15 ==> Disease-Class=Asthma 15 co nf:(1) 3949. Functional Concept=used Individual Behavior=visit 15 ==> Disease-Class=As thma 15 conf:(1) 3950. Functional Concept=using Laboratory Procedure=screening 15 ==> Disease-Cl ass=Asthma 15 conf:(1) 3951. Functional Concept=increase Disease or Syndrome=asthma 15 ==> Disease-Cla ss=Asthma 15 conf:(1) 3952. Functional Concept=affect Sign or Symptom=condition 15 ==> Disease-Class= Asthma 15 conf:(1) 3953. Spatial Concept=between Human=subjects 15 ==> Disease-Class=Asthma 15 conf:(1) 3954. Spatial Concept=within Physiologic Function=change in 15 ==> Disease-Clas s=Asthma 15 conf:(1) 3955. Spatial Concept=within Mental Process=experienced 15 ==> Disease-Class=As thma 15 conf:(1) 3956. Spatial Concept=gastrointestinal Body Location or Region=hepatic 15 ==> D isease-Class=Asthma 15 conf:(1) 3957. Disease or Syndrome=asthma Health Care Related Organization=hospitalized 15 ==> Disease-Class=Asthma 15 conf:(1) 3958. Disease or Syndrome=asthma Organic Chemical=saba 15 ==> Disease-Class=Ast hma 15 conf:(1) 3959. Disease or Syndrome=lower respiratory tract infection Laboratory Procedur e=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 3960. Finding=life Human=subject 15 ==> Disease-Class=Asthma 15 conf:(1) 3961. Professional or Occupational Group=investigator Human-caused Phenomenon o r Process=safety 15 ==> Disease-Class=Asthma 15 conf:(1) 3962. Age Group=aged Human=subjects 15 ==> Disease-Class=Asthma 15 conf:(1) 3963. Regulation or Law=informed consent Human=subjects 15 ==> Disease-Class=As thma 15 conf:(1) 3964. Regulation or Law=informed consent Human=subject 15 ==> Disease-Class=Ast hma 15 conf:(1) 3965. Sign or Symptom=symptoms Human=subjects 15 ==> Disease-Class=Asthma 15 conf:(1) 3966. Sign or Symptom=condition Human=subject 15 ==> Disease-Class=Asthma 15 conf:(1) 3967. Body Space or Junction=oral Human=subject 15 ==> Disease-Class=Asthma 15 conf:(1) 3968. Patient or Disabled Group=patients Health Care Activity=diagnosis Disease or Syndrome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 3969. Patient or Disabled Group=patients NUMERAL=1.0 Laboratory Procedure=scree ning 15 ==> Disease-Class=Asthma 15 conf:(1) 3970. Patient or Disabled Group=patients Organism Attribute=female Age Group=ag ed 15 ==> Disease-Class=Asthma 15 conf:(1) 3971. Patient or Disabled Group=patients Disease or Syndrome=asthma Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 3972. Patient or Disabled Group=patient Research Activity=study Qualitative Con cept=at risk 15 ==> Disease-Class=Asthma 15 conf:(1) 3973. Patient or Disabled Group=patient Qualitative Concept=at risk Activity=pu t 15 ==> Disease-Class=Asthma 15 conf:(1)

3974. Health Care Activity=diagnosis NUMERAL=3.0 Disease or Syndrome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 3975. Health Care Activity=hospitalization Disease or Syndrome=asthma Human=sub ject 15 ==> Disease-Class=Asthma 15 conf:(1) 3976. Health Care Activity=documented SYMBOL=- UNIT=% 15 ==> Disease-Class=Asth ma 15 conf:(1) 3977. Health Care Activity=documented SYMBOL=- Laboratory Procedure=screening 1 5 ==> Disease-Class=Asthma 15 conf:(1) 3978. Health Care Activity=documented SYMBOL=>= Disease or Syndrome=asthma 15 = => Disease-Class=Asthma 15 conf:(1) 3979. Temporal Concept=years NUMERAL=10.0 Behavior Problem=smoking 15 ==> Disea se-Class=Asthma 15 conf:(1) 3980. Temporal Concept=years NUMERAL=6.0 Idea or Concept=eligible 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3981. Temporal Concept=years NUMERAL=6.0 Research Activity=study 15 ==> Disease -Class=Asthma 15 conf:(1) 3982. Temporal Concept=years NUMERAL=18.0 Organism Attribute=female 15 ==> Dise ase-Class=Asthma 15 conf:(1) 3983. Temporal Concept=years NUMERAL=12.0 Age Group=age 15 ==> Disease-Class=As thma 15 conf:(1) 3984. Temporal Concept=years NUMERAL=16.0 Research Activity=study 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3985. Temporal Concept=days Pharmacologic Substance=investigational drug Spatia l Concept=within 15 ==> Disease-Class=Asthma 15 conf:(1) 3986. Temporal Concept=history of Research Activity=study Professional or Occup ational Group=investigator 15 ==> Disease-Class=Asthma 15 conf:(1) 3987. Temporal Concept=history of Disease or Syndrome=asthma Finding=life 15 == > Disease-Class=Asthma 15 conf:(1) 3988. Temporal Concept=prior to NO=no SYMBOL=- 15 ==> Disease-Class=Asthma 15 conf:(1) 3989. Temporal Concept=prior to NO=not Individual Behavior=visit 15 ==> Disease -Class=Asthma 15 conf:(1) 3990. Temporal Concept=prior to SYMBOL=>= Disease or Syndrome=ics 15 ==> Diseas e-Class=Asthma 15 conf:(1) 3991. Temporal Concept=prior to NUMERAL=5.0 Spatial Concept=within 15 ==> Disea se-Class=Asthma 15 conf:(1) 3992. Temporal Concept=prior to Quantitative Concept=dose Individual Behavior=v isit 15 ==> Disease-Class=Asthma 15 conf:(1) 3993. Temporal Concept=prior to Research Activity=study Regulation or Law=infor med consent 15 ==> Disease-Class=Asthma 15 conf:(1) 3994. Temporal Concept=prior to Functional Concept=used Spatial Concept=within 15 ==> Disease-Class=Asthma 15 conf:(1) 3995. Temporal Concept=prior to Disease or Syndrome=asthma Human=subject 15 ==> Disease-Class=Asthma 15 conf:(1) 3996. Temporal Concept=prior to Disease or Syndrome=ics Laboratory Procedure=sc reening 15 ==> Disease-Class=Asthma 15 conf:(1) 3997. Temporal Concept=weeks NUMERAL=12.0 Spatial Concept=within 15 ==> Disease -Class=Asthma 15 conf:(1) 3998. Temporal Concept=weeks Spatial Concept=within Disease or Syndrome=respira tory tract infection 15 ==> Disease-Class=Asthma 15 conf:(1) 3999. Temporal Concept=months NUMERAL=6.0 Qualitative Concept=last 15 ==> Disea se-Class=Asthma 15 conf:(1) 4000. Temporal Concept=months Qualitative Concept=last Disease or Syndrome=asth ma 15 ==> Disease-Class=Asthma 15 conf:(1) 4001. Temporal Concept=months Disease or Syndrome=asthma Individual Behavior=vi sit 15 ==> Disease-Class=Asthma 15 conf:(1) 4002. Temporal Concept=year SYMBOL=> NUMERAL=1.0 15 ==> Disease-Class=Asthma 15 conf:(1) 4003. Temporal Concept=period Research Activity=study Disease or Syndrome=asthm a 15 ==> Disease-Class=Asthma 15 conf:(1)

4004. Temporal Concept=period Laboratory Procedure=screening Individual Behavio r=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4005. Temporal Concept=before SYMBOL=- Individual Behavior=visit 15 ==> Disease -Class=Asthma 15 conf:(1) 4006. Temporal Concept=preceding NUMERAL=3.0 Individual Behavior=visit 15 ==> D isease-Class=Asthma 15 conf:(1) 4007. Temporal Concept=post Pharmacologic Substance=bronchodilator UNIT=% 15 == > Disease-Class=Asthma 15 conf:(1) 4008. Intellectual Product=method Finding=sexually active Willing=agree 15 ==> Disease-Class=Asthma 15 conf:(1) 4009. Clinical Attribute=parenteral Functional Concept=use of Body Space or Jun ction=oral 15 ==> Disease-Class=Asthma 15 conf:(1) 4010. Pharmacologic Substance=agonists Idea or Concept=acting Qualitative Conce pt=beta 15 ==> Disease-Class=Asthma 15 conf:(1) 4011. Pharmacologic Substance=albuterol Quantitative Concept=mcg UNIT=% 15 ==> Disease-Class=Asthma 15 conf:(1) 4012. Pharmacologic Substance=medication Spatial Concept=within Disease or Synd rome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 4013. Pharmacologic Substance=steroids Functional Concept=use of Disease or Syn drome=diseases 15 ==> Disease-Class=Asthma 15 conf:(1) 4014. Pharmacologic Substance=steroids Disease or Syndrome=diseases Activity=in haled 15 ==> Disease-Class=Asthma 15 conf:(1) 4015. Pharmacologic Substance=steroids Activity=inhaled Body Space or Junction= oral 15 ==> Disease-Class=Asthma 15 conf:(1) 4016. Pharmacologic Substance=agonist Idea or Concept=acting Laboratory Procedu re=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 4017. Pharmacologic Substance=corticosteroids Research Activity=study Activity= inhaled 15 ==> Disease-Class=Asthma 15 conf:(1) 4018. Pharmacologic Substance=corticosteroids Therapeutic or Preventive Procedu re=treatment Functional Concept=systemic 15 ==> Disease-Class=Asthma 15 conf: (1) 4019. Pharmacologic Substance=corticosteroids Disease or Syndrome=asthma Labora tory Procedure=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 4020. Pharmacologic Substance=corticosteroids Activity=inhaled Individual Behav ior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4021. Pharmacologic Substance=drug Quantitative Concept=dose Research Activity= study 15 ==> Disease-Class=Asthma 15 conf:(1) 4022. Pharmacologic Substance=salbutamol NUMERAL=1.0 Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4023. Pharmacologic Substance=salbutamol Spatial Concept=within Diagnostic Proc edure=fev1 15 ==> Disease-Class=Asthma 15 conf:(1) 4024. Pharmacologic Substance=bronchodilator SYMBOL=- Qualitative Concept=pre 1 5 ==> Disease-Class=Asthma 15 conf:(1) 4025. Pharmacologic Substance=bronchodilator UNIT=% Laboratory Procedure=screen ing 15 ==> Disease-Class=Asthma 15 conf:(1) 4026. NO=no SYMBOL=- Idea or Concept=acting 15 ==> Disease-Class=Asthma 15 c onf:(1) 4027. NO=not Organism Attribute=female Human=subjects 15 ==> Disease-Class=Asth ma 15 conf:(1) 4028. NO=not Professional or Occupational Group=investigator Human=subject 15 = => Disease-Class=Asthma 15 conf:(1) 4029. SYMBOL=- NUMERAL=6.0 Idea or Concept=acting 15 ==> Disease-Class=Asthma 1 5 conf:(1) 4030. SYMBOL=- NUMERAL=6.0 Individual Behavior=visit 15 ==> Disease-Class=Asthm a 15 conf:(1) 4031. SYMBOL=- NUMERAL=12.0 Disease or Syndrome=asthma 15 ==> Disease-Class=Ast hma 15 conf:(1) 4032. SYMBOL=- NUMERAL=80.0 UNIT=% 15 ==> Disease-Class=Asthma 15 conf:(1) 4033. SYMBOL=- Quantitative Concept=pack Therapeutic or Preventive Procedure=ex 15 ==> Disease-Class=Asthma 15 conf:(1)

4034. SYMBOL=- Quantitative Concept=kg UNIT=m2 15 ==> Disease-Class=Asthma 15 conf:(1) 4035. SYMBOL=- Idea or Concept=predicted Laboratory Procedure=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 4036. SYMBOL=- Research Activity=study Therapeutic or Preventive Procedure=trea tment 15 ==> Disease-Class=Asthma 15 conf:(1) 4037. SYMBOL=- Research Activity=study Spatial Concept=up 15 ==> Disease-Class= Asthma 15 conf:(1) 4038. SYMBOL=- Therapeutic or Preventive Procedure=treatment Laboratory Procedu re=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 4039. SYMBOL=- Functional Concept=including Spatial Concept=within 15 ==> Disea se-Class=Asthma 15 conf:(1) 4040. SYMBOL=- Spatial Concept=within Human=subjects 15 ==> Disease-Class=Asthm a 15 conf:(1) 4041. SYMBOL=- Disease or Syndrome=asthma Diagnostic Procedure=fev1 15 ==> Dise ase-Class=Asthma 15 conf:(1) 4042. SYMBOL=- Disease or Syndrome=asthma Body Space or Junction=oral 15 ==> Di sease-Class=Asthma 15 conf:(1) 4043. SYMBOL=> NUMERAL=70.0 Idea or Concept=predicted 15 ==> Disease-Class=Asth ma 15 conf:(1) 4044. SYMBOL=> UNIT=% Laboratory Procedure=screening 15 ==> Disease-Class=Asthm a 15 conf:(1) 4045. SYMBOL=>= NUMERAL=4.0 Disease or Syndrome=asthma 15 ==> Disease-Class=Ast hma 15 conf:(1) 4046. SYMBOL=>= NUMERAL=3.0 Laboratory Procedure=screening 15 ==> Disease-Class =Asthma 15 conf:(1) 4047. SYMBOL=>= NUMERAL=12.0 Diagnostic Procedure=fev1 15 ==> Disease-Class=Ast hma 15 conf:(1) 4048. SYMBOL=>= Qualitative Concept=stable Disease or Syndrome=asthma 15 ==> Di sease-Class=Asthma 15 conf:(1) 4049. SYMBOL=>= Functional Concept=use of Activity=inhaled 15 ==> Disease-Class =Asthma 15 conf:(1) 4050. SYMBOL=>= Functional Concept=increase Diagnostic Procedure=fev1 15 ==> Di sease-Class=Asthma 15 conf:(1) 4051. SYMBOL=>= Spatial Concept=within Laboratory Procedure=screening 15 ==> Di sease-Class=Asthma 15 conf:(1) 4052. SYMBOL=>= Laboratory Procedure=screening Human=subjects 15 ==> Disease-Cl ass=Asthma 15 conf:(1) 4053. NUMERAL=10.0 Therapeutic or Preventive Procedure=ex Behavior Problem=smok ers 15 ==> Disease-Class=Asthma 15 conf:(1) 4054. NUMERAL=10.0 Finding=smoking history Behavior Problem=smokers 15 ==> Dise ase-Class=Asthma 15 conf:(1) 4055. NUMERAL=2.0 Idea or Concept=acting Activity=inhaled 15 ==> Disease-Class= Asthma 15 conf:(1) 4056. NUMERAL=2.0 Disease or Syndrome=asthma Laboratory Procedure=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 4057. NUMERAL=2.0 Disease or Syndrome=asthma Individual Behavior=visit 15 ==> D isease-Class=Asthma 15 conf:(1) 4058. NUMERAL=3.0 Qualitative Concept=last Individual Behavior=visit 15 ==> Dis ease-Class=Asthma 15 conf:(1) 4059. NUMERAL=1.0 UNIT=% Idea or Concept=predicted 15 ==> Disease-Class=Asthma 15 conf:(1) 4060. NUMERAL=1.0 Qualitative Concept=has Individual Behavior=visit 15 ==> Dise ase-Class=Asthma 15 conf:(1) 4061. NUMERAL=1.0 Therapeutic or Preventive Procedure=treatment Disease or Synd rome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 4062. NUMERAL=85.0 Idea or Concept=predicted Diagnostic Procedure=fev1 15 ==> D isease-Class=Asthma 15 conf:(1) 4063. Quantitative Concept=one Spatial Concept=within Laboratory Procedure=scre ening 15 ==> Disease-Class=Asthma 15 conf:(1)

4064. Quantitative Concept=one Spatial Concept=within Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4065. Quantitative Concept=exacerbation Qualitative Concept=last Spatial Concep t=within 15 ==> Disease-Class=Asthma 15 conf:(1) 4066. Quantitative Concept=exacerbation Therapeutic or Preventive Procedure=tre atment Disease or Syndrome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 4067. Quantitative Concept=baseline Qualitative Concept=from Laboratory Procedu re=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 4068. Idea or Concept=eligible Research Activity=study Human=subject 15 ==> Dis ease-Class=Asthma 15 conf:(1) 4069. Idea or Concept=opinion Qualitative Concept=at risk Professional or Occup ational Group=investigator 15 ==> Disease-Class=Asthma 15 conf:(1) 4070. Idea or Concept=opinion Qualitative Concept=at risk Activity=put 15 ==> D isease-Class=Asthma 15 conf:(1) 4071. Research Activity=study Qualitative Concept=has Human=subject 15 ==> Dise ase-Class=Asthma 15 conf:(1) 4072. Research Activity=study Therapeutic or Preventive Procedure=treatment Spa tial Concept=within 15 ==> Disease-Class=Asthma 15 conf:(1) 4073. Research Activity=study Therapeutic or Preventive Procedure=treatment Dis ease or Syndrome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 4074. Research Activity=study Functional Concept=participate Human=subject 15 = => Disease-Class=Asthma 15 conf:(1) 4075. Research Activity=study Disease or Syndrome=asthma Individual Behavior=vi sit 15 ==> Disease-Class=Asthma 15 conf:(1) 4076. Research Activity=study Individual Behavior=participation Human=subjects 15 ==> Disease-Class=Asthma 15 conf:(1) 4077. Research Activity=study Capacity=able to Compliance=comply 15 ==> Disease -Class=Asthma 15 conf:(1) 4078. Research Activity=entry Spatial Concept=within Disease or Syndrome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 4079. Qualitative Concept=at risk Activity=put Individual Behavior=participatio n 15 ==> Disease-Class=Asthma 15 conf:(1) 4080. Functional Concept=including Laboratory Procedure=screening Individual Be havior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4081. Functional Concept=increase Laboratory Procedure=screening Individual Beh avior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4082. Disease or Syndrome=asthma Health Care Related Organization=emergency roo m Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4083. Finding=written Regulation or Law=informed consent Willing=willing 15 ==> Disease-Class=Asthma 15 conf:(1) 4084. Patient or Disabled Group=patients Temporal Concept=prior to Spatial Conc ept=within Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4085. Patient or Disabled Group=patient Research Activity=study Qualitative Con cept=at risk Activity=put 15 ==> Disease-Class=Asthma 15 conf:(1) 4086. Health Care Activity=diagnosis Temporal Concept=months NUMERAL=6.0 Diseas e or Syndrome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 4087. Temporal Concept=years SYMBOL=- Quantitative Concept=pack Behavior Proble m=smoking 15 ==> Disease-Class=Asthma 15 conf:(1) 4088. Temporal Concept=years NUMERAL=6.0 Idea or Concept=eligible Research Acti vity=study 15 ==> Disease-Class=Asthma 15 conf:(1) 4089. Temporal Concept=history of SYMBOL=- Disease or Syndrome=asthma Finding=l ife 15 ==> Disease-Class=Asthma 15 conf:(1) 4090. Temporal Concept=after UNIT=% Functional Concept=increase Diagnostic Proc edure=fev1 15 ==> Disease-Class=Asthma 15 conf:(1) 4091. Temporal Concept=prior to SYMBOL=- Disease or Syndrome=asthma Laboratory Procedure=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 4092. Temporal Concept=prior to SYMBOL=>= Disease or Syndrome=asthma Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4093. Temporal Concept=prior to Disease or Syndrome=asthma Laboratory Procedure =screening Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1)

4094. Temporal Concept=weeks Pharmacologic Substance=corticosteroids Spatial Co ncept=within Body Space or Junction=oral 15 ==> Disease-Class=Asthma 15 conf: (1) 4095. Temporal Concept=weeks NUMERAL=4.0 Spatial Concept=within Laboratory Proc edure=screening 15 ==> Disease-Class=Asthma 15 conf:(1) 4096. Temporal Concept=post Pharmacologic Substance=bronchodilator UNIT=% Diagn ostic Procedure=fev1 15 ==> Disease-Class=Asthma 15 conf:(1) 4097. Pharmacologic Substance=steroids Functional Concept=use of Disease or Syn drome=diseases Activity=inhaled 15 ==> Disease-Class=Asthma 15 conf:(1) 4098. Pharmacologic Substance=agonist Idea or Concept=acting Qualitative Concep t=beta Activity=inhaled 15 ==> Disease-Class=Asthma 15 conf:(1) 4099. Pharmacologic Substance=corticosteroids Therapeutic or Preventive Procedu re=treatment Disease or Syndrome=asthma Body Space or Junction=oral 15 ==> Disea se-Class=Asthma 15 conf:(1) 4100. Pharmacologic Substance=corticosteroids Laboratory Procedure=screening Bo dy Space or Junction=oral Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4101. Pharmacologic Substance=salbutamol UNIT=% Spatial Concept=within Diagnost ic Procedure=fev1 15 ==> Disease-Class=Asthma 15 conf:(1) 4102. Pharmacologic Substance=bronchodilator SYMBOL=< UNIT=% Diagnostic Procedu re=fev1 15 ==> Disease-Class=Asthma 15 conf:(1) 4103. NO=not Spatial Concept=within Individual Behavior=visit Human=subject 15 ==> Disease-Class=Asthma 15 conf:(1) 4104. SYMBOL=- UNIT=% Qualitative Concept=pre Diagnostic Procedure=fev1 15 ==> Disease-Class=Asthma 15 conf:(1) 4105. SYMBOL=- Idea or Concept=acting Qualitative Concept=long Activity=inhaled 15 ==> Disease-Class=Asthma 15 conf:(1) 4106. SYMBOL=- Idea or Concept=acting Therapeutic or Preventive Procedure=treat ment Activity=inhaled 15 ==> Disease-Class=Asthma 15 conf:(1) 4107. SYMBOL=- Idea or Concept=acting Disease or Syndrome=asthma Activity=inhal ed 15 ==> Disease-Class=Asthma 15 conf:(1) 4108. SYMBOL=- Qualitative Concept=beta Therapeutic or Preventive Procedure=tre atment Activity=inhaled 15 ==> Disease-Class=Asthma 15 conf:(1) 4109. SYMBOL=- Disease or Syndrome=asthma Laboratory Procedure=screening Indivi dual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4110. SYMBOL=> NUMERAL=70.0 UNIT=% Idea or Concept=predicted 15 ==> Disease-Cla ss=Asthma 15 conf:(1) 4111. SYMBOL=>= NUMERAL=12.0 UNIT=% Diagnostic Procedure=fev1 15 ==> Disease-Cl ass=Asthma 15 conf:(1) 4112. SYMBOL=>= UNIT=% Functional Concept=increase Diagnostic Procedure=fev1 15 ==> Disease-Class=Asthma 15 conf:(1) 4113. NUMERAL=1.0 Quantitative Concept=exacerbation Spatial Concept=within Dise ase or Syndrome=asthma 15 ==> Disease-Class=Asthma 15 conf:(1) 4114. NUMERAL=1.0 Spatial Concept=within Individual Behavior=visit Human=subjec ts 15 ==> Disease-Class=Asthma 15 conf:(1) 4115. NUMERAL=1.0 Disease or Syndrome=asthma Laboratory Procedure=screening Ind ividual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4116. NUMERAL=1.0 Laboratory Procedure=screening Individual Behavior=visit Huma n=subject 15 ==> Disease-Class=Asthma 15 conf:(1) 4117. NUMERAL=85.0 UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 1 5 ==> Disease-Class=Asthma 15 conf:(1) 4118. Quantitative Concept=ml Laboratory or Test Result=pc20 Diagnostic Procedu re=fev1 Organic Chemical=methacholine 15 ==> Disease-Class=Asthma 15 conf:(1) 4119. UNIT=% Idea or Concept=predicted Diagnostic Procedure=fev1 Human=subjects 15 ==> Disease-Class=Asthma 15 conf:(1) 4120. Idea or Concept=opinion Qualitative Concept=at risk Professional or Occup ational Group=investigator Activity=put 15 ==> Disease-Class=Asthma 15 conf:( 1) 4121. Spatial Concept=within Laboratory Procedure=screening Individual Behavior =visit Human=subject 15 ==> Disease-Class=Asthma 15 conf:(1)

4122. Spatial Concept=within Activity=inhaled Body Space or Junction=oral Indiv idual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1) 4123. Disease or Syndrome=asthma Laboratory Procedure=screening Body Space or J unction=oral Individual Behavior=visit 15 ==> Disease-Class=Asthma 15 conf:(1 )